HSFY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.97783652
2epithelial cilium movement (GO:0003351)9.84835446
3motile cilium assembly (GO:0044458)9.82347552
4spermatid development (GO:0007286)9.47603575
5regulation of cilium movement (GO:0003352)8.23494173
6cilium movement (GO:0003341)8.14780789
7protein targeting to Golgi (GO:0000042)7.93837544
8single fertilization (GO:0007338)7.85464263
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.72061926
10establishment of protein localization to Golgi (GO:0072600)7.60598080
11piRNA metabolic process (GO:0034587)7.51569538
12retrograde transport, vesicle recycling within Golgi (GO:0000301)7.39565086
13male meiosis (GO:0007140)7.35341026
14sperm capacitation (GO:0048240)7.14413296
15synaptonemal complex organization (GO:0070193)7.11939824
16synaptonemal complex assembly (GO:0007130)6.86249458
17rRNA methylation (GO:0031167)6.81910209
18response to pheromone (GO:0019236)6.73603967
19fertilization (GO:0009566)6.53998795
20microtubule depolymerization (GO:0007019)6.44649190
21spermatogenesis (GO:0007283)6.44082885
22male gamete generation (GO:0048232)6.41733411
23negative regulation of inclusion body assembly (GO:0090084)6.18293493
24organic cation transport (GO:0015695)6.05141781
25gamete generation (GO:0007276)5.91401843
26protein localization to Golgi apparatus (GO:0034067)5.90954386
27phosphatidylethanolamine biosynthetic process (GO:0006646)5.82736171
28rRNA modification (GO:0000154)5.69472781
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.41130496
30phosphatidylethanolamine metabolic process (GO:0046337)5.38815288
31calcium ion-dependent exocytosis (GO:0017156)5.37908654
32germ cell development (GO:0007281)5.30296788
33regulation of inclusion body assembly (GO:0090083)5.26420015
34cell recognition (GO:0008037)5.25019344
35ventricular system development (GO:0021591)5.21799534
36DNA methylation involved in gamete generation (GO:0043046)4.87691762
37spermatid nucleus differentiation (GO:0007289)4.85720592
38male meiosis I (GO:0007141)4.85143997
39regulation of microtubule-based movement (GO:0060632)4.83283791
40chromosome organization involved in meiosis (GO:0070192)4.78419814
41cellular ketone body metabolic process (GO:0046950)4.77593131
42RNA destabilization (GO:0050779)4.73829975
43microtubule severing (GO:0051013)4.68976611
44multicellular organismal reproductive process (GO:0048609)4.65543151
45glycerol ether metabolic process (GO:0006662)4.63979986
46seminiferous tubule development (GO:0072520)4.40341926
47meiotic nuclear division (GO:0007126)4.33739750
48coenzyme catabolic process (GO:0009109)4.32497273
49regulation of Rab GTPase activity (GO:0032313)4.32324308
50positive regulation of Rab GTPase activity (GO:0032851)4.32324308
51ether metabolic process (GO:0018904)4.28758291
52chromosome condensation (GO:0030261)4.26860216
53ketone body metabolic process (GO:1902224)4.19288357
54regulation of phosphoprotein phosphatase activity (GO:0043666)4.19174453
55musculoskeletal movement (GO:0050881)4.14384109
56multicellular organismal movement (GO:0050879)4.14384109
57microtubule nucleation (GO:0007020)4.07108515
58DNA packaging (GO:0006323)4.05604643
59left/right pattern formation (GO:0060972)4.05439323
60negative regulation of Rho protein signal transduction (GO:0035024)3.94300978
61regulation of transcription involved in cell fate commitment (GO:0060850)3.93646437
62glomerular visceral epithelial cell development (GO:0072015)3.87642925
63monoubiquitinated protein deubiquitination (GO:0035520)3.87021575
64chaperone-mediated protein complex assembly (GO:0051131)3.86841987
65meiosis I (GO:0007127)3.85808326
66genitalia morphogenesis (GO:0035112)3.77403017
67multicellular organismal development (GO:0007275)3.75924223
68polyamine biosynthetic process (GO:0006596)3.70657246
69glomerular epithelial cell development (GO:0072310)3.64803609
70protein polyglutamylation (GO:0018095)3.56567869
71single strand break repair (GO:0000012)3.54737030
72protein K11-linked deubiquitination (GO:0035871)3.48294211
73sequestering of actin monomers (GO:0042989)3.43676620
74regulation of somitogenesis (GO:0014807)3.37140870
75meiotic cell cycle (GO:0051321)3.37116567
76protein localization to cilium (GO:0061512)3.34778883
77chromatin silencing (GO:0006342)3.33904636
78microtubule polymerization or depolymerization (GO:0031109)3.33521093
79sexual reproduction (GO:0019953)3.26424238
80regulation of spindle checkpoint (GO:0090231)3.14477102
81response to acidic pH (GO:0010447)3.12394923
82polyol catabolic process (GO:0046174)3.07384135
83nucleoside diphosphate phosphorylation (GO:0006165)3.06905088
84alditol metabolic process (GO:0019400)3.06780261
85intra-Golgi vesicle-mediated transport (GO:0006891)3.03866221
86carnitine transport (GO:0015879)3.03498755
87amino-acid betaine transport (GO:0015838)3.03498755
88lactate metabolic process (GO:0006089)3.00984564
89GTP biosynthetic process (GO:0006183)3.00410972
90detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.99412537
91synapsis (GO:0007129)2.97799800
92cranial nerve morphogenesis (GO:0021602)2.94997205
93cilium organization (GO:0044782)2.94929433
94glycolytic process (GO:0006096)2.94306958
95axoneme assembly (GO:0035082)2.93679632
96intraciliary transport (GO:0042073)2.90870389
97cellular response to pH (GO:0071467)2.90685317
98carnitine transmembrane transport (GO:1902603)2.88945981
99microtubule-based movement (GO:0007018)2.88079110
100protein refolding (GO:0042026)2.86398570
101cellular component assembly involved in morphogenesis (GO:0010927)2.84310503
102cilium assembly (GO:0042384)2.84040521
103centriole assembly (GO:0098534)2.83825861
104meiotic cell cycle process (GO:1903046)2.83716771
105nucleus organization (GO:0006997)2.82540754
106spinal cord motor neuron differentiation (GO:0021522)2.82170783
107mitotic sister chromatid cohesion (GO:0007064)2.79408668
108cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.78664281
109cilium morphogenesis (GO:0060271)2.78343198
110urinary tract smooth muscle contraction (GO:0014848)2.78247599
111negative regulation of organelle assembly (GO:1902116)2.77605015
112membrane protein intracellular domain proteolysis (GO:0031293)2.71218028
113histone H3-K9 demethylation (GO:0033169)2.70997588
114positive regulation of guanylate cyclase activity (GO:0031284)2.70183873
115positive regulation of macrophage activation (GO:0043032)2.68960339
116gene silencing by RNA (GO:0031047)2.68400101
117interferon-gamma secretion (GO:0072643)2.67303469
118UTP biosynthetic process (GO:0006228)2.66551833
119vesicle transport along microtubule (GO:0047496)2.66246977
120glycerol metabolic process (GO:0006071)2.66173487
121receptor recycling (GO:0001881)2.65381611
122protein-DNA complex disassembly (GO:0032986)2.65267807
123nucleosome disassembly (GO:0006337)2.65267807
124regulation of interleukin-13 production (GO:0032656)2.65188518
125mitochondrion degradation (GO:0000422)2.61083149
126protein depolymerization (GO:0051261)2.60340137
127centriole replication (GO:0007099)2.49183698
128regulation of meiosis I (GO:0060631)2.49104433
129RNA localization (GO:0006403)2.45896006
130regulation of centriole replication (GO:0046599)2.45405074
131peptidyl-glutamic acid modification (GO:0018200)2.42184194
132fusion of sperm to egg plasma membrane (GO:0007342)14.7919721
133cell wall macromolecule catabolic process (GO:0016998)13.6036508
134cell wall macromolecule metabolic process (GO:0044036)13.6036508
135sperm motility (GO:0030317)13.3854665
136acrosome assembly (GO:0001675)12.4385429
137multicellular organism reproduction (GO:0032504)12.0415681
138sperm-egg recognition (GO:0035036)11.9404624
139acrosome reaction (GO:0007340)11.4997591
140plasma membrane fusion (GO:0045026)11.2749373
141cell-cell recognition (GO:0009988)10.7151656
142binding of sperm to zona pellucida (GO:0007339)10.6551127
143cilium or flagellum-dependent cell motility (GO:0001539)10.5155649
144reproduction (GO:0000003)10.0910512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.56164422
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.57061206
3EZH2_22144423_ChIP-Seq_EOC_Human4.03262279
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.81339946
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.32217314
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.11250820
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04979120
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.94851258
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.72668815
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.42073623
11FUS_26573619_Chip-Seq_HEK293_Human2.41466467
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40339826
13VDR_22108803_ChIP-Seq_LS180_Human2.32978109
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32573755
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.26216114
16* FLI1_27457419_Chip-Seq_LIVER_Mouse2.12862636
17ZNF274_21170338_ChIP-Seq_K562_Hela2.06986354
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03639881
19CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.03632855
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.99441732
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99364421
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.89703680
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.88994412
24* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88556708
25* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.86396281
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85377721
27ER_23166858_ChIP-Seq_MCF-7_Human1.84841929
28GBX2_23144817_ChIP-Seq_PC3_Human1.82816846
29TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.79282215
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.78907286
31STAT1_17558387_ChIP-Seq_HELA_Human1.75215225
32GATA1_26923725_Chip-Seq_HPCs_Mouse1.74262454
33DROSHA_22980978_ChIP-Seq_HELA_Human1.73520684
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73099581
35ERA_21632823_ChIP-Seq_H3396_Human1.71634759
36KAP1_22055183_ChIP-Seq_ESCs_Mouse1.70716325
37P300_19829295_ChIP-Seq_ESCs_Human1.68829621
38RAC3_21632823_ChIP-Seq_H3396_Human1.67007019
39* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.65770463
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.62578623
41GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.61206806
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.61175057
43KDM2B_26808549_Chip-Seq_REH_Human1.60113242
44WDR5_24793694_ChIP-Seq_LNCAP_Human1.59941233
45NANOG_20526341_ChIP-Seq_ESCs_Human1.59602501
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.57499688
47* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57333494
48AR_25329375_ChIP-Seq_VCAP_Human1.55299790
49FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54317520
50MYC_19829295_ChIP-Seq_ESCs_Human1.54022008
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.52674079
52CTCF_27219007_Chip-Seq_Bcells_Human1.49851279
53GATA3_21867929_ChIP-Seq_CD8_Mouse1.47248889
54SOX2_22085726_ChIP-Seq_NPCs_Mouse1.46664282
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46659921
56CBP_20019798_ChIP-Seq_JUKART_Human1.46659921
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45031104
58* NFE2_27457419_Chip-Seq_LIVER_Mouse1.42243362
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41413904
60TAF2_19829295_ChIP-Seq_ESCs_Human1.41409031
61SMAD4_21799915_ChIP-Seq_A2780_Human1.39286517
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39187095
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39096541
64CBX2_22325352_ChIP-Seq_293T-Rex_Human1.38800228
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38699388
66* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37112870
67OCT4_20526341_ChIP-Seq_ESCs_Human1.36001932
68TP53_18474530_ChIP-ChIP_U2OS_Human1.34542086
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34360751
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34057856
71* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33770086
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.33520523
73TBL1_22424771_ChIP-Seq_293T_Human1.33467267
74HNFA_21074721_ChIP-Seq_CACO-2_Human1.33353549
75GATA3_21867929_ChIP-Seq_TH1_Mouse1.32810919
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32781215
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32596353
78TAF15_26573619_Chip-Seq_HEK293_Human1.32407345
79* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31826218
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.31149624
81STAT3_23295773_ChIP-Seq_U87_Human1.30913368
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30114083
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29959748
84RUNX2_22187159_ChIP-Seq_PCA_Human1.29412330
85REST_21632747_ChIP-Seq_MESCs_Mouse1.28580518
86AR_21572438_ChIP-Seq_LNCaP_Human1.27835757
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.26344232
88CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26250187
89RBPJ_21746931_ChIP-Seq_IB4_Human1.25678957
90ETV1_20927104_ChIP-Seq_GIST48_Human1.25677527
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25192657
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25020093
93SMAD3_21741376_ChIP-Seq_ESCs_Human1.24384804
94GF1_26923725_Chip-Seq_HPCs_Mouse1.22872566
95* CRX_20693478_ChIP-Seq_RETINA_Mouse1.22037398
96* NANOG_18555785_Chip-Seq_ESCs_Mouse1.21975492
97P53_21459846_ChIP-Seq_SAOS-2_Human1.21138763
98RNF2_27304074_Chip-Seq_NSC_Mouse1.20505378
99FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20374242
100PHF8_20622853_ChIP-Seq_HELA_Human1.18690286
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18593477
102CTCF_20526341_ChIP-Seq_ESCs_Human1.18522839
103EZH2_27294783_Chip-Seq_ESCs_Mouse1.18255275
104* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18146540
105SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17933330
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17073635
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16936517
108SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.16855405
109NANOG_19829295_ChIP-Seq_ESCs_Human1.13598785
110SOX2_19829295_ChIP-Seq_ESCs_Human1.13598785
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.12641559
112* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12561151
113SMAD4_21741376_ChIP-Seq_HESCs_Human1.11697733
114AHR_22903824_ChIP-Seq_MCF-7_Human1.11661795
115* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11628650
116* OCT4_18555785_Chip-Seq_ESCs_Mouse1.11513196
117GATA3_21878914_ChIP-Seq_MCF-7_Human1.11400493
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10658612
119RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10618722
120TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10535682
121* P53_22387025_ChIP-Seq_ESCs_Mouse1.10230287
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09554173
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09540441
124CEBPB_22108803_ChIP-Seq_LS180_Human1.08634906
125RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08298625
126SMC4_20622854_ChIP-Seq_HELA_Human1.08022553
127* CMYC_18555785_Chip-Seq_ESCs_Mouse1.06062765
128PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05933092
129SPI1_26923725_Chip-Seq_HPCs_Mouse1.05677765
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05643459
131* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05284447
132TP63_22573176_ChIP-Seq_HFKS_Human1.05133438
133* EZH2_27294783_Chip-Seq_NPCs_Mouse1.04324564
134PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04251978
135OCT1_27270436_Chip-Seq_PROSTATE_Human1.03877881
136BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02916227
137ESET_19884257_ChIP-Seq_ESCs_Mouse1.02861848
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02469415
139GATA6_21074721_ChIP-Seq_CACO-2_Human1.02439033
140P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02394032
141* P300_18555785_Chip-Seq_ESCs_Mouse1.01846252
142YY1_22570637_ChIP-Seq_MALME-3M_Human1.01512969
143* KLF4_18555785_Chip-Seq_ESCs_Mouse1.00739866
144NCOR_22424771_ChIP-Seq_293T_Human1.00607834
145KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00515853
146FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00411827
147BCL6_27268052_Chip-Seq_Bcells_Human1.00356621
148* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99805493
149TCF4_23295773_ChIP-Seq_U87_Human0.99666768
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99604433
151NFYA_21822215_ChIP-Seq_K562_Human0.99531025
152SOX9_26525672_Chip-Seq_HEART_Mouse0.98832670
153* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98428205
154ERG_20517297_ChIP-Seq_VCAP_Human0.97834329
155TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.97699137
156* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97678356
157PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97121864
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96445610
159* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95599600
160GF1B_26923725_Chip-Seq_HPCs_Mouse0.95524373
161SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95112994
162* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94376290
163* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94376290
164RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93709805
165NFYB_21822215_ChIP-Seq_K562_Human0.92746598
166CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91844254
167SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91626588
168LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91187614
169MYC_27129775_Chip-Seq_CORNEA_Mouse0.90524904
170* STAT3_18555785_Chip-Seq_ESCs_Mouse0.90258270
171* SOX2_18555785_Chip-Seq_ESCs_Mouse0.89320569
172RARA_24833708_ChIP-Seq_LIVER_Mouse0.89140822
173STAT3_18555785_ChIP-Seq_MESCs_Mouse0.89117675
174* PU1_27457419_Chip-Seq_LIVER_Mouse0.87619697
175NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87461571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.11660099
2MP0001929_abnormal_gametogenesis5.59629830
3MP0008877_abnormal_DNA_methylation4.37660213
4MP0002210_abnormal_sex_determination3.50962174
5MP0002161_abnormal_fertility/fecundity3.31810792
6MP0001145_abnormal_male_reproductive2.97145551
7MP0002653_abnormal_ependyma_morphology2.61444199
8MP0000653_abnormal_sex_gland2.60387075
9MP0005670_abnormal_white_adipose2.42783618
10MP0001485_abnormal_pinna_reflex2.20494965
11MP0001486_abnormal_startle_reflex2.04784590
12MP0005410_abnormal_fertilization16.3159049
13MP0003718_maternal_effect1.86056871
14MP0004859_abnormal_synaptic_plasticity1.81027243
15MP0005623_abnormal_meninges_morphology1.70701935
16MP0002160_abnormal_reproductive_system1.66792953
17MP0000678_abnormal_parathyroid_gland1.60127201
18MP0004510_myositis1.51939759
19MP0002282_abnormal_trachea_morphology1.45864969
20MP0004233_abnormal_muscle_weight1.42473393
21MP0003646_muscle_fatigue1.40981891
22MP0002127_abnormal_cardiovascular_syste1.33323717
23MP0005310_abnormal_salivary_gland1.32559458
24MP0003880_abnormal_central_pattern1.31367928
25MP0001963_abnormal_hearing_physiology1.28828854
26MP0002735_abnormal_chemical_nociception1.21760314
27MP0002272_abnormal_nervous_system1.19727984
28MP0001905_abnormal_dopamine_level1.18627605
29MP0005647_abnormal_sex_gland1.15898980
30MP0002067_abnormal_sensory_capabilities1.15550616
31MP0008058_abnormal_DNA_repair1.15254659
32MP0000749_muscle_degeneration1.15101448
33MP0005379_endocrine/exocrine_gland_phen1.15075741
34MP0001765_abnormal_ion_homeostasis1.12980396
35MP0000026_abnormal_inner_ear1.11965425
36MP0009046_muscle_twitch1.07055068
37MP0008004_abnormal_stomach_pH1.04579845
38MP0002733_abnormal_thermal_nociception1.03734335
39MP0001984_abnormal_olfaction1.01472676
40MP0004084_abnormal_cardiac_muscle0.98219088
41MP0009745_abnormal_behavioral_response0.97734830
42MP0002249_abnormal_larynx_morphology0.95851626
43MP0003635_abnormal_synaptic_transmissio0.95007605
44MP0000955_abnormal_spinal_cord0.93563808
45MP0002557_abnormal_social/conspecific_i0.91546772
46MP0002138_abnormal_hepatobiliary_system0.89940651
47MP0008995_early_reproductive_senescence0.89679627
48MP0002234_abnormal_pharynx_morphology0.88818605
49MP0005248_abnormal_Harderian_gland0.88355997
50MP0003315_abnormal_perineum_morphology0.87145798
51MP0002572_abnormal_emotion/affect_behav0.86853684
52MP0005389_reproductive_system_phenotype0.86351077
53MP0006292_abnormal_olfactory_placode0.86268464
54MP0009697_abnormal_copulation0.85879619
55MP0004085_abnormal_heartbeat0.85351769
56MP0001529_abnormal_vocalization0.82323421
57MP0001970_abnormal_pain_threshold0.82291619
58MP0005167_abnormal_blood-brain_barrier0.81950732
59MP0001501_abnormal_sleep_pattern0.81252371
60MP0004484_altered_response_of0.80397967
61MP0003137_abnormal_impulse_conducting0.79308930
62MP0002734_abnormal_mechanical_nocicepti0.78572903
63MP0010386_abnormal_urinary_bladder0.77981141
64MP0005395_other_phenotype0.76071300
65MP0003011_delayed_dark_adaptation0.75484879
66MP0008057_abnormal_DNA_replication0.72356986
67MP0008569_lethality_at_weaning0.71362552
68MP0009053_abnormal_anal_canal0.70353334
69MP0002837_dystrophic_cardiac_calcinosis0.69085093
70MP0010094_abnormal_chromosome_stability0.68984101
71MP0002064_seizures0.68569524
72MP0002102_abnormal_ear_morphology0.64390801
73MP0002822_catalepsy0.62095843
74MP0006276_abnormal_autonomic_nervous0.61686158
75MP0003115_abnormal_respiratory_system0.61603042
76MP0000049_abnormal_middle_ear0.60735163
77MP0005636_abnormal_mineral_homeostasis0.60488626
78MP0002638_abnormal_pupillary_reflex0.59600508
79MP0000230_abnormal_systemic_arterial0.57563771
80MP0003632_abnormal_nervous_system0.56489305
81MP0002063_abnormal_learning/memory/cond0.55405751
82MP0005377_hearing/vestibular/ear_phenot0.54862956
83MP0003878_abnormal_ear_physiology0.54862956
84MP0001666_abnormal_nutrient_absorption0.52829200
85MP0003699_abnormal_female_reproductive0.52343423
86MP0003136_yellow_coat_color0.52331342
87MP0002882_abnormal_neuron_morphology0.50678916
88MP0005451_abnormal_body_composition0.50178452
89MP0010329_abnormal_lipoprotein_level0.49661670
90MP0000681_abnormal_thyroid_gland0.49311802
91MP0004215_abnormal_myocardial_fiber0.49262582
92MP0002184_abnormal_innervation0.48919772
93MP0001324_abnormal_eye_pigmentation0.48850904
94MP0005253_abnormal_eye_physiology0.48790066
95MP0003950_abnormal_plasma_membrane0.48221471
96MP0005551_abnormal_eye_electrophysiolog0.47659232
97MP0001764_abnormal_homeostasis0.47492277
98MP0002928_abnormal_bile_duct0.43065877
99MP0003786_premature_aging0.42974992
100MP0004036_abnormal_muscle_relaxation0.42602309
101MP0003329_amyloid_beta_deposits0.41955416
102MP0001293_anophthalmia0.41340303
103MP0008007_abnormal_cellular_replicative0.40029234
104MP0000358_abnormal_cell_content/0.39369050
105MP0009115_abnormal_fat_cell0.38588782
106MP0001119_abnormal_female_reproductive0.37525969
107MP0002269_muscular_atrophy0.37317230
108MP0005666_abnormal_adipose_tissue0.37164814
109MP0002132_abnormal_respiratory_system0.35884963
110MP0010307_abnormal_tumor_latency0.35866337
111MP0005391_vision/eye_phenotype0.35451004
112MP0003879_abnormal_hair_cell0.34918356
113MP0006072_abnormal_retinal_apoptosis0.34622255
114MP0005397_hematopoietic_system_phenotyp0.34027402
115MP0001545_abnormal_hematopoietic_system0.34027402
116MP0004019_abnormal_vitamin_homeostasis0.33439543
117MP0002971_abnormal_brown_adipose0.33096187
118MP0002736_abnormal_nociception_after0.30543381
119MP0006036_abnormal_mitochondrial_physio0.30070299
120MP0000569_abnormal_digit_pigmentation0.27987621
121MP0003111_abnormal_nucleus_morphology0.27452497
122MP0004133_heterotaxia0.26814068
123MP0000534_abnormal_ureter_morphology0.26441282
124MP0004145_abnormal_muscle_electrophysio0.26356006
125MP0003861_abnormal_nervous_system0.26184253
126MP0009278_abnormal_bone_marrow0.23857462
127MP0003633_abnormal_nervous_system0.23544090
128MP0004270_analgesia0.23117911
129MP0004811_abnormal_neuron_physiology0.22720228
130MP0004134_abnormal_chest_morphology0.22606424
131MP0001661_extended_life_span0.22593736
132MP0002152_abnormal_brain_morphology0.22169082
133MP0003942_abnormal_urinary_system0.21040276
134MP0005423_abnormal_somatic_nervous0.18552586
135MP0005195_abnormal_posterior_eye0.18472766
136MP0003631_nervous_system_phenotype0.18080634
137MP0002139_abnormal_hepatobiliary_system0.17931021
138MP0002169_no_abnormal_phenotype0.17347278
139MP0003948_abnormal_gas_homeostasis0.17173770
140MP0000604_amyloidosis0.17169085
141MP0002873_normal_phenotype0.17071321
142MP0001730_embryonic_growth_arrest0.16829290
143MP0000751_myopathy0.16678438
144MP0001968_abnormal_touch/_nociception0.15832088
145MP0002092_abnormal_eye_morphology0.15622497
146MP0000313_abnormal_cell_death0.14866626
147MP0004808_abnormal_hematopoietic_stem0.14663376
148MP0000462_abnormal_digestive_system0.14037611
149MP0002295_abnormal_pulmonary_circulatio0.13896502
150MP0003959_abnormal_lean_body0.13691957
151MP0001348_abnormal_lacrimal_gland0.13243285
152MP0001440_abnormal_grooming_behavior0.13237643
153MP0004742_abnormal_vestibular_system0.13032190
154MP0001727_abnormal_embryo_implantation0.12924346
155MP0002405_respiratory_system_inflammati0.12901603
156MP0002084_abnormal_developmental_patter0.11959571
157MP0001986_abnormal_taste_sensitivity0.11498318
158MP0002752_abnormal_somatic_nervous0.11408815
159MP0002229_neurodegeneration0.11063452

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.58102198
2Abnormal respiratory epithelium morphology (HP:0012253)9.29359521
3Abnormal respiratory motile cilium morphology (HP:0005938)9.29359521
4Abnormal ciliary motility (HP:0012262)7.85979125
5Rhinitis (HP:0012384)7.68064957
6Chronic bronchitis (HP:0004469)7.44333349
7Infertility (HP:0000789)6.62136610
8Chronic hepatic failure (HP:0100626)6.45770864
9Nasal polyposis (HP:0100582)6.27656222
10Severe visual impairment (HP:0001141)5.75434902
11Resting tremor (HP:0002322)5.36509441
12Abnormality of the nasal mucosa (HP:0000433)5.14841244
13Bronchitis (HP:0012387)4.55544716
14Bronchiectasis (HP:0002110)4.45345774
15Male infertility (HP:0003251)4.41158613
16Postural instability (HP:0002172)4.31912358
17Hyperkalemia (HP:0002153)4.21232226
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.13624113
19Nephronophthisis (HP:0000090)4.12254680
20Abnormality of macular pigmentation (HP:0008002)3.92900226
21Attenuation of retinal blood vessels (HP:0007843)3.84322006
22Progressive cerebellar ataxia (HP:0002073)3.74152171
23Recurrent sinusitis (HP:0011108)3.69848622
24Cone-rod dystrophy (HP:0000548)3.66648786
25Bony spicule pigmentary retinopathy (HP:0007737)3.66248706
26Abnormal spermatogenesis (HP:0008669)3.46933468
27Potter facies (HP:0002009)3.30870969
28Facial shape deformation (HP:0011334)3.30870969
29Recurrent otitis media (HP:0000403)3.26410792
30Abnormality of dental color (HP:0011073)3.24647187
31Amelogenesis imperfecta (HP:0000705)3.23977321
32Hypoalphalipoproteinemia (HP:0003233)3.18456028
33Aplasia/Hypoplasia of the earlobes (HP:0009906)3.12793025
34Abnormality of the renal medulla (HP:0100957)3.11902067
35Hypoplasia of the thymus (HP:0000778)3.07286819
36Menstrual irregularities (HP:0000858)2.93145236
37Medial flaring of the eyebrow (HP:0010747)2.91472777
38Renovascular hypertension (HP:0100817)2.87312586
39Myokymia (HP:0002411)2.83832171
40Abnormal rod and cone electroretinograms (HP:0008323)2.78648546
41Progressive sensorineural hearing impairment (HP:0000408)2.77075194
42Tubulointerstitial nephritis (HP:0001970)2.76220499
43Atonic seizures (HP:0010819)2.71300721
44Recurrent bronchitis (HP:0002837)2.63018960
45Abnormality of midbrain morphology (HP:0002418)2.62147387
46Molar tooth sign on MRI (HP:0002419)2.62147387
47Truncal obesity (HP:0001956)2.61342558
48Enlarged epiphyses (HP:0010580)2.57247100
49Generalized aminoaciduria (HP:0002909)2.54860949
50Tubular atrophy (HP:0000092)2.52763145
51Insulin-resistant diabetes mellitus (HP:0000831)2.42716684
52Gonadotropin excess (HP:0000837)2.39432945
53Impulsivity (HP:0100710)2.38284598
54Abnormality of potassium homeostasis (HP:0011042)2.35475214
55Tubulointerstitial abnormality (HP:0001969)2.35435462
56Azoospermia (HP:0000027)2.32259850
57Abnormality of the costochondral junction (HP:0000919)2.28201730
58Hypoplastic ischia (HP:0003175)2.24951433
59Portal hypertension (HP:0001409)2.23256767
60Abnormality of the aortic arch (HP:0012303)2.19111040
61Abnormality of urine glucose concentration (HP:0011016)2.16216239
62Glycosuria (HP:0003076)2.16216239
63Hyperuricemia (HP:0002149)2.14888124
64Increased purine levels (HP:0004368)2.14888124
65Optic nerve hypoplasia (HP:0000609)2.14511740
66Focal segmental glomerulosclerosis (HP:0000097)2.11235875
67Unilateral renal agenesis (HP:0000122)2.11148745
68Ventricular tachycardia (HP:0004756)2.10211279
69Polyuria (HP:0000103)2.08982257
70Osteomalacia (HP:0002749)2.08625026
71Intellectual disability, moderate (HP:0002342)2.08242401
72Abnormality of the hepatic vasculature (HP:0006707)2.06716695
73Abnormality of the ischium (HP:0003174)2.03769115
74Recurrent corneal erosions (HP:0000495)2.03535669
75Widely patent fontanelles and sutures (HP:0004492)2.00080813
76Dynein arm defect of respiratory motile cilia (HP:0012255)13.6082081
77Absent/shortened dynein arms (HP:0200106)13.6082081
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4062693
79Amblyopia (HP:0000646)1.99207442
80Congenital sensorineural hearing impairment (HP:0008527)1.98025299
81Bradycardia (HP:0001662)1.95068450
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93604890
83Retinal atrophy (HP:0001105)1.92252918
84Progressive hearing impairment (HP:0001730)1.90648064
85Tubulointerstitial fibrosis (HP:0005576)1.89895506
86Tetany (HP:0001281)1.89497163
87Cholecystitis (HP:0001082)1.86787674
88Abnormal gallbladder physiology (HP:0012438)1.86787674
89Dyschromatopsia (HP:0007641)1.86638001
90Postaxial foot polydactyly (HP:0001830)1.83912900
91Gait imbalance (HP:0002141)1.83682125
92Spontaneous abortion (HP:0005268)1.82759690
93Subcapsular cataract (HP:0000523)1.81943241
94Congenital primary aphakia (HP:0007707)1.81824671
95Abnormal EKG (HP:0003115)1.81747668
96Hypophosphatemic rickets (HP:0004912)1.81378499
97Photophobia (HP:0000613)1.80544526
98Hypolipoproteinemia (HP:0010981)1.78654140
99Occipital encephalocele (HP:0002085)1.78026488
100Hypoalbuminemia (HP:0003073)1.77612164
101Abnormal albumin level (HP:0012116)1.77612164
102Abnormality of the lower motor neuron (HP:0002366)1.73997872
103Stage 5 chronic kidney disease (HP:0003774)1.72752271
104Decreased central vision (HP:0007663)1.72714934
105Congenital hepatic fibrosis (HP:0002612)1.72535877
106Atrial fibrillation (HP:0005110)1.72393559
107Abnormality of permanent molar morphology (HP:0011071)1.70693002
108Abnormality of the dental root (HP:0006486)1.70693002
109Taurodontia (HP:0000679)1.70693002
110Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70313290
111Spastic tetraparesis (HP:0001285)1.66571239
112Fibular hypoplasia (HP:0003038)1.65041059
113Polydipsia (HP:0001959)1.64921026
114Abnormal drinking behavior (HP:0030082)1.64921026
115Heterotopia (HP:0002282)1.64670186
116Aplasia/Hypoplasia of the lens (HP:0008063)1.63864056
117Abnormality of the renal cortex (HP:0011035)1.63472662
118Abnormality of molar (HP:0011077)1.59333549
119Abnormality of molar morphology (HP:0011070)1.59333549
120Abnormality of renal excretion (HP:0011036)1.57584562
121Abnormality of the dental pulp (HP:0006479)1.57198347
122Short ribs (HP:0000773)1.57123744
123Chronic sinusitis (HP:0011109)1.57089364
124Microglossia (HP:0000171)1.56834642
125Postaxial hand polydactyly (HP:0001162)1.56545982
126Hypoplasia of the capital femoral epiphysis (HP:0003090)1.56432634
127Nephrogenic diabetes insipidus (HP:0009806)1.54268836
128Choroideremia (HP:0001139)1.51359247
129Amyotrophic lateral sclerosis (HP:0007354)1.49250558
130Oculomotor apraxia (HP:0000657)1.48331085
131Renal dysplasia (HP:0000110)1.45442327
132Facial cleft (HP:0002006)1.45354969
133Abnormality of dentin (HP:0010299)1.43754132
134Absent frontal sinuses (HP:0002688)1.42349080
135Bell-shaped thorax (HP:0001591)1.41361640
136Pancreatic fibrosis (HP:0100732)1.40812004
137Genital tract atresia (HP:0001827)1.39615004
138Vaginal atresia (HP:0000148)1.39598589
139Abnormal biliary tract physiology (HP:0012439)1.37272741
140Bile duct proliferation (HP:0001408)1.37272741
141Poor coordination (HP:0002370)1.35189936
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.33768921
143Cystic liver disease (HP:0006706)1.32782563
144Hemorrhage of the eye (HP:0011885)1.30758814
145Double outlet right ventricle (HP:0001719)1.30251631
146Congenital malformation of the right heart (HP:0011723)1.30251631
147J-shaped sella turcica (HP:0002680)1.30187751
148Asymmetric septal hypertrophy (HP:0001670)1.28037976
149Abnormality of saccadic eye movements (HP:0000570)1.27779295
150Decreased electroretinogram (ERG) amplitude (HP:0000654)1.25812445
151Deformed sella turcica (HP:0002681)1.23642507
152Supernumerary spleens (HP:0009799)1.23204636
153Absent epiphyses (HP:0010577)1.22050485
154Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.22050485
155Abnormal urine output (HP:0012590)1.21587919
156Fatigable weakness (HP:0003473)1.20980777
157Abnormality of the neuromuscular junction (HP:0003398)1.20980777
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.19919603
159Easy fatigability (HP:0003388)1.19903600
160Median cleft lip (HP:0000161)1.18160522
161Neurofibrillary tangles (HP:0002185)1.17768852
162Cerebellar dysplasia (HP:0007033)1.17099336
163Abnormality of ocular smooth pursuit (HP:0000617)1.16194244
164True hermaphroditism (HP:0010459)1.14499945
165Bundle branch block (HP:0011710)1.14340617
166Short thorax (HP:0010306)1.13648624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.64490030
2PDK48.64490030
3PDK25.59835760
4TESK15.51316106
5PRKD34.55056680
6INSRR3.96395900
7ICK3.90945678
8PLK23.57976265
9BRD43.22388656
10MAP4K22.73498208
11DDR22.46939005
12PTK2B2.28769392
13PNCK2.22681955
14TNIK2.20718551
15WNK42.20299046
16STK392.12537510
17PIK3CG1.98845582
18STK381.57126521
19NEK21.54107303
20MAP3K91.51639376
21DYRK1B1.50506822
22OBSCN1.39584464
23TAOK31.13749317
24PDK11.11257630
25FRK1.08573095
26SGK2231.04588373
27SGK4941.04588373
28DYRK31.04537273
29KSR21.03616919
30TYRO30.90465309
31TIE10.84818218
32MST1R0.82654244
33MUSK0.82648678
34PBK0.82470479
35ZAK0.77771859
36WNK10.77628321
37IRAK10.75432586
38MAPK150.74317841
39AKT30.71889215
40TESK20.70710842
41PASK0.70141786
42CAMK10.69379683
43LATS20.69311684
44NLK0.66287477
45CHEK20.65388653
46TTK0.64406163
47SGK20.64386122
48STK30.63544559
49CAMK1D0.62778078
50ACVR1B0.62719102
51CCNB10.62540042
52CAMK1G0.61909038
53LMTK20.61234280
54LATS10.60846029
55PDPK10.60386493
56MAP3K10.59556278
57MAP2K60.57563191
58TLK10.56339194
59ADRBK20.55781239
60PLK40.53122687
61ROCK10.51975496
62CDK70.48444471
63CASK0.48207725
64RIPK40.46291355
65ARAF0.45199379
66PINK10.44452828
67NTRK20.44180788
68EEF2K0.43386256
69CHEK10.43187980
70CAMK40.43015548
71PRKAA20.41235511
72STK38L0.39210194
73SIK20.38577015
74RPS6KA20.36037057
75PAK10.35929870
76MAPK130.35768445
77UHMK10.35394777
78WEE10.34895335
79IRAK20.33510136
80KIT0.33030449
81MAPK10.32593488
82NTRK30.32374491
83ATM0.32234099
84PRKCG0.31699683
85PHKG10.31410164
86PHKG20.31410164
87SGK30.30359432
88ATR0.29549415
89DYRK20.28777221
90SGK10.28630681
91RPS6KA50.28433342
92CDK50.27263125
93PAK20.25479779
94GRK10.24388107
95MTOR0.23209987
96BRSK20.22807566
97MAP2K20.22731502
98MYLK0.22655848
99CSNK1A10.21815744
100NEK60.20422514
101MAPKAPK50.19890956
102MARK20.19606492
103PLK10.19527189
104CAMKK10.19300834
105MAP3K100.19081005
106CDC70.19071220
107CSNK1G30.18203068
108CSNK1A1L0.18041751
109PRKAA10.17834511
110PKN10.16817222
111RPS6KB10.15794501
112PRKG20.13810332
113CDK120.13724379
114PRKCZ0.12764550
115CDK150.12455590
116PRKCQ0.12094030
117CSNK2A10.10712361
118CDK180.09900652
119PRKG10.09772418
120BRSK10.09373557
121CSNK1D0.08815206
122MARK10.08776952
123CDK11A0.08565398
124PAK40.08007304
125MAP2K70.07688649
126GSK3B0.07473926
127MAP3K40.06549326
128BRAF0.05795111
129STK100.05748130
130RPS6KA10.05635702
131STK110.05631909
132PRKACG0.05622600
133CSNK2A20.05520288
134CDK10.04815628
135CAMK2A0.04710123
136CDK140.04412513
137MARK30.03800310
138CDK20.03696617
139MAPK80.03611895
140PRKCB0.03001257
141WNK30.02315703
142PRKDC0.01669064
143YES10.01453244
144PRKCA0.01407535
145BMPR1B0.01381604
146EGFR0.01307647
147CDK30.01044621
148PRKACA0.00834035
149AURKA0.00827353
150PRKACB0.00324885
151PRKCD0.00199158
152RPS6KA3-0.0237072
153ZAP70-0.0220475
154CSF1R-0.0129804
155CDK6-0.0048640

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.45919037
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.44895271
3Olfactory transduction_Homo sapiens_hsa047404.24344573
4Vitamin B6 metabolism_Homo sapiens_hsa007504.23823935
5Fatty acid biosynthesis_Homo sapiens_hsa000614.07074498
6Pyruvate metabolism_Homo sapiens_hsa006203.87848571
7Propanoate metabolism_Homo sapiens_hsa006403.15986494
8Butanoate metabolism_Homo sapiens_hsa006503.15409813
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.73829602
10Glucagon signaling pathway_Homo sapiens_hsa049222.72786931
11Linoleic acid metabolism_Homo sapiens_hsa005912.65608588
12Basal transcription factors_Homo sapiens_hsa030222.58942582
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.28826753
14Nitrogen metabolism_Homo sapiens_hsa009102.27595705
15Pentose phosphate pathway_Homo sapiens_hsa000302.18520695
16Selenocompound metabolism_Homo sapiens_hsa004502.16604746
17Carbohydrate digestion and absorption_Homo sapiens_hsa049732.07837502
18Glycosaminoglycan degradation_Homo sapiens_hsa005312.01327096
19Glycerolipid metabolism_Homo sapiens_hsa005612.00467827
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89201750
21Arginine biosynthesis_Homo sapiens_hsa002201.85545884
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.84201799
23PPAR signaling pathway_Homo sapiens_hsa033201.81713351
24Oocyte meiosis_Homo sapiens_hsa041141.80685589
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.75197333
26Fanconi anemia pathway_Homo sapiens_hsa034601.70394423
27Amphetamine addiction_Homo sapiens_hsa050311.61050917
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.60120574
29Phototransduction_Homo sapiens_hsa047441.54777031
30Nicotine addiction_Homo sapiens_hsa050331.52399613
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51681254
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.49885018
33Dorso-ventral axis formation_Homo sapiens_hsa043201.49611601
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.41358287
35Mineral absorption_Homo sapiens_hsa049781.39977738
36Carbon metabolism_Homo sapiens_hsa012001.39806817
37Cardiac muscle contraction_Homo sapiens_hsa042601.39574720
38Fructose and mannose metabolism_Homo sapiens_hsa000511.36102558
39Phenylalanine metabolism_Homo sapiens_hsa003601.36049317
40Huntingtons disease_Homo sapiens_hsa050161.34497308
41Type II diabetes mellitus_Homo sapiens_hsa049301.29545859
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.29411048
43Ether lipid metabolism_Homo sapiens_hsa005651.23426188
44Renin secretion_Homo sapiens_hsa049241.22748910
45Fatty acid degradation_Homo sapiens_hsa000711.22335841
46Fat digestion and absorption_Homo sapiens_hsa049751.18237416
47Fatty acid metabolism_Homo sapiens_hsa012121.17693665
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17543312
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16882140
50Morphine addiction_Homo sapiens_hsa050321.14147069
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11985761
52Arginine and proline metabolism_Homo sapiens_hsa003301.11888168
53mRNA surveillance pathway_Homo sapiens_hsa030151.10433986
54Purine metabolism_Homo sapiens_hsa002301.04064586
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96937714
56Antigen processing and presentation_Homo sapiens_hsa046120.96736023
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95962066
58Biosynthesis of amino acids_Homo sapiens_hsa012300.95148451
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94836522
60GABAergic synapse_Homo sapiens_hsa047270.94052428
61Gap junction_Homo sapiens_hsa045400.91885092
62Collecting duct acid secretion_Homo sapiens_hsa049660.91599339
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89717403
64RNA transport_Homo sapiens_hsa030130.89358443
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.88671714
66Glutathione metabolism_Homo sapiens_hsa004800.87010201
67Oxytocin signaling pathway_Homo sapiens_hsa049210.86838098
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82026572
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79149152
70Chemical carcinogenesis_Homo sapiens_hsa052040.77995066
71Renin-angiotensin system_Homo sapiens_hsa046140.77504390
72Long-term potentiation_Homo sapiens_hsa047200.72697877
73Serotonergic synapse_Homo sapiens_hsa047260.72410246
74Insulin secretion_Homo sapiens_hsa049110.71410950
75beta-Alanine metabolism_Homo sapiens_hsa004100.68761861
76Hedgehog signaling pathway_Homo sapiens_hsa043400.64805805
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64534773
78Calcium signaling pathway_Homo sapiens_hsa040200.63715614
79Bile secretion_Homo sapiens_hsa049760.63088283
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61725678
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.61147172
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60954226
83Thyroid hormone synthesis_Homo sapiens_hsa049180.60097024
84Estrogen signaling pathway_Homo sapiens_hsa049150.58127526
85Arachidonic acid metabolism_Homo sapiens_hsa005900.56285818
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55539242
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54457523
88ABC transporters_Homo sapiens_hsa020100.52675277
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52641345
90Circadian rhythm_Homo sapiens_hsa047100.50899020
91Systemic lupus erythematosus_Homo sapiens_hsa053220.50141103
92Synaptic vesicle cycle_Homo sapiens_hsa047210.47462187
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.47182161
94Cholinergic synapse_Homo sapiens_hsa047250.47110795
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45560812
96Protein digestion and absorption_Homo sapiens_hsa049740.45558437
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44660729
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44474697
99Inositol phosphate metabolism_Homo sapiens_hsa005620.44100501
100Salivary secretion_Homo sapiens_hsa049700.43797438
101Legionellosis_Homo sapiens_hsa051340.43270931
102Tyrosine metabolism_Homo sapiens_hsa003500.42276712
103Metabolic pathways_Homo sapiens_hsa011000.42248224
104Taste transduction_Homo sapiens_hsa047420.42058571
105Type I diabetes mellitus_Homo sapiens_hsa049400.41988005
106Pancreatic secretion_Homo sapiens_hsa049720.41814836
107Peroxisome_Homo sapiens_hsa041460.41132103
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41025131
109MAPK signaling pathway_Homo sapiens_hsa040100.40564164
110AMPK signaling pathway_Homo sapiens_hsa041520.39142921
111Endocytosis_Homo sapiens_hsa041440.37981900
112Gastric acid secretion_Homo sapiens_hsa049710.36102381
113Sulfur metabolism_Homo sapiens_hsa009200.35585458
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35029278
115N-Glycan biosynthesis_Homo sapiens_hsa005100.33313430
116cAMP signaling pathway_Homo sapiens_hsa040240.33172259
117Tryptophan metabolism_Homo sapiens_hsa003800.32653342
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32239828
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31410144
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30833074
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.29773908
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.29750646
123VEGF signaling pathway_Homo sapiens_hsa043700.29643470
124Tight junction_Homo sapiens_hsa045300.27489621
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26807889
126Autoimmune thyroid disease_Homo sapiens_hsa053200.26797491
127Starch and sucrose metabolism_Homo sapiens_hsa005000.26707194
128Circadian entrainment_Homo sapiens_hsa047130.26465681
129Cocaine addiction_Homo sapiens_hsa050300.25380701
130Pyrimidine metabolism_Homo sapiens_hsa002400.20959991
131Alcoholism_Homo sapiens_hsa050340.18644071
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16347374
133Wnt signaling pathway_Homo sapiens_hsa043100.16195516
134Retinol metabolism_Homo sapiens_hsa008300.14596001
135Glutamatergic synapse_Homo sapiens_hsa047240.12629902
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.11941028
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11657268
138B cell receptor signaling pathway_Homo sapiens_hsa046620.07210869
139RNA degradation_Homo sapiens_hsa030180.06545783

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