HSFY3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1auditory behavior (GO:0031223)8.02405852
2neurotransmitter-gated ion channel clustering (GO:0072578)7.09440106
3postsynaptic membrane organization (GO:0001941)6.18589637
4mechanosensory behavior (GO:0007638)5.77257502
5neuron cell-cell adhesion (GO:0007158)5.66329544
6regulation of cilium movement (GO:0003352)5.51347859
7presynaptic membrane assembly (GO:0097105)5.49021249
8response to auditory stimulus (GO:0010996)5.46068322
9negative regulation of axon guidance (GO:1902668)5.12961456
10transmission of nerve impulse (GO:0019226)4.95263438
11vocalization behavior (GO:0071625)4.89781722
12ovulation cycle (GO:0042698)4.89612579
13C4-dicarboxylate transport (GO:0015740)4.71041805
14presynaptic membrane organization (GO:0097090)4.60896579
15axonal fasciculation (GO:0007413)4.23988638
16retinal ganglion cell axon guidance (GO:0031290)4.18216928
17pyrimidine nucleobase catabolic process (GO:0006208)4.00389419
18synapse assembly (GO:0007416)3.97578684
19regulation of female gonad development (GO:2000194)3.95544304
20pyrimidine nucleotide catabolic process (GO:0006244)3.89463194
21positive regulation of synapse assembly (GO:0051965)3.68080834
22startle response (GO:0001964)3.66111983
23synaptic vesicle endocytosis (GO:0048488)3.65703287
24neuronal action potential propagation (GO:0019227)3.64612456
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.64146575
26neuron recognition (GO:0008038)3.61355984
27polyol catabolic process (GO:0046174)3.56685744
28negative regulation of astrocyte differentiation (GO:0048712)3.56345519
29cochlea development (GO:0090102)3.56062690
30regulation of glomerular filtration (GO:0003093)3.55123983
31glycerol metabolic process (GO:0006071)3.52650962
32regulation of microtubule-based movement (GO:0060632)3.50558823
33protein localization to synapse (GO:0035418)3.48142546
34positive regulation of dendritic spine morphogenesis (GO:0061003)3.47063984
35dentate gyrus development (GO:0021542)3.46813044
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.44118431
37pyrimidine ribonucleoside catabolic process (GO:0046133)3.42103455
38regulation of axon guidance (GO:1902667)3.40880710
39negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.38657335
40cell morphogenesis involved in neuron differentiation (GO:0048667)3.36362994
41neuron projection extension involved in neuron projection guidance (GO:1902284)3.31897032
42axon extension involved in axon guidance (GO:0048846)3.31897032
43regulation of centriole replication (GO:0046599)3.29364993
44alditol metabolic process (GO:0019400)3.28305745
45short-term memory (GO:0007614)3.26905866
46olfactory bulb development (GO:0021772)3.23586359
47central nervous system projection neuron axonogenesis (GO:0021952)3.22735088
48nucleobase catabolic process (GO:0046113)3.21703299
49response to pheromone (GO:0019236)3.20935783
50negative regulation of axon extension involved in axon guidance (GO:0048843)3.15034221
51neuronal ion channel clustering (GO:0045161)3.12315659
52neurofilament cytoskeleton organization (GO:0060052)3.08162235
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.05380868
54regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.03257928
55histone H2A acetylation (GO:0043968)3.01700822
56mitotic spindle organization (GO:0007052)3.00874300
57regulation of respiratory system process (GO:0044065)3.00051755
58sex differentiation (GO:0007548)2.97047010
59glycosphingolipid biosynthetic process (GO:0006688)2.94099363
60positive regulation of gastrulation (GO:2000543)2.93412844
61mismatch repair (GO:0006298)2.93399384
62isoprenoid biosynthetic process (GO:0008299)2.90686875
63ganglion development (GO:0061548)2.89121971
64glutamate receptor signaling pathway (GO:0007215)2.88886602
65attachment of spindle microtubules to kinetochore (GO:0008608)2.88770290
66galactose catabolic process (GO:0019388)2.88735477
67synaptic transmission, glutamatergic (GO:0035249)2.87527011
68epithelial cell differentiation involved in kidney development (GO:0035850)2.86649826
69spinal cord development (GO:0021510)2.86327199
70heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.84308265
71neuron fate specification (GO:0048665)2.80748108
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80169129
73regulation of neuron projection regeneration (GO:0070570)2.80151727
74regulation of axon regeneration (GO:0048679)2.80151727
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80103068
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.76674430
77regulation of neuron migration (GO:2001222)2.76269208
78transepithelial transport (GO:0070633)2.72618744
79positive regulation of dendritic spine development (GO:0060999)2.72523973
80calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.72431874
81dendritic spine morphogenesis (GO:0060997)2.71314951
82microtubule polymerization or depolymerization (GO:0031109)2.70194474
83positive regulation of membrane potential (GO:0045838)2.70092053
84negative regulation of glial cell differentiation (GO:0045686)2.69740875
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.68252509
86regulation of pigment cell differentiation (GO:0050932)2.67912051
87regulation of timing of cell differentiation (GO:0048505)2.66956244
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.66138054
89vesicle localization (GO:0051648)2.65936879
90monoubiquitinated protein deubiquitination (GO:0035520)2.65439006
91nucleoside diphosphate catabolic process (GO:0009134)2.65019115
92regulation of development, heterochronic (GO:0040034)2.63431780
93regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.63129898
94hindbrain development (GO:0030902)2.62949038
95synapse organization (GO:0050808)2.62820269
96negative regulation of microtubule polymerization (GO:0031115)2.60298503
97negative regulation of membrane potential (GO:0045837)2.60032590
98positive regulation of oligodendrocyte differentiation (GO:0048714)2.57761361
99central nervous system neuron axonogenesis (GO:0021955)2.57538600
100axonogenesis (GO:0007409)2.57477657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.39786794
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.06507903
3GBX2_23144817_ChIP-Seq_PC3_Human4.00663094
4TAF15_26573619_Chip-Seq_HEK293_Human3.59971693
5ZNF274_21170338_ChIP-Seq_K562_Hela3.31597444
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.29241583
7ZFP57_27257070_Chip-Seq_ESCs_Mouse3.06479016
8EZH2_22144423_ChIP-Seq_EOC_Human2.98596955
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.89221360
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.86074814
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.61942864
12FUS_26573619_Chip-Seq_HEK293_Human2.53801609
13VDR_22108803_ChIP-Seq_LS180_Human2.49882263
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.25794246
15P300_19829295_ChIP-Seq_ESCs_Human2.20752069
16IGF1R_20145208_ChIP-Seq_DFB_Human2.18301444
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17365862
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08638100
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06614202
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05028057
21SMAD4_21799915_ChIP-Seq_A2780_Human1.92546520
22EWS_26573619_Chip-Seq_HEK293_Human1.92012981
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88093922
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.81183950
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78525271
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76975428
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.76088017
28ER_23166858_ChIP-Seq_MCF-7_Human1.75982530
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70541304
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70102904
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69628741
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69628741
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64320112
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.62662384
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.62412840
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57953296
37CBP_20019798_ChIP-Seq_JUKART_Human1.57953296
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.50629031
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50430077
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49671136
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48266367
42RNF2_27304074_Chip-Seq_NSC_Mouse1.48262379
43REST_21632747_ChIP-Seq_MESCs_Mouse1.47733041
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46856556
45TP53_18474530_ChIP-ChIP_U2OS_Human1.46518507
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45470533
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.44135550
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43024482
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41180338
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.40648372
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40281893
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40153463
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.37474236
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34097220
55AR_25329375_ChIP-Seq_VCAP_Human1.34047298
56RUNX2_22187159_ChIP-Seq_PCA_Human1.33043565
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32707047
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32276121
59STAT3_23295773_ChIP-Seq_U87_Human1.30487270
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.28788197
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28514632
62SOX9_26525672_Chip-Seq_HEART_Mouse1.27455713
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.26639967
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.25747573
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24984015
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23522445
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19520548
68CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19326961
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19019757
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18465722
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17651712
72SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16404756
73TP53_22573176_ChIP-Seq_HFKS_Human1.14561236
74AR_21572438_ChIP-Seq_LNCaP_Human1.12505352
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12262782
76TCF4_18268006_ChIP-ChIP_LS174T_Human1.11790543
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11448905
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.11382383
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.10143677
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.08571355
81TCF4_22108803_ChIP-Seq_LS180_Human1.08543229
82TCF4_23295773_ChIP-Seq_U87_Human1.08161528
83BCAT_22108803_ChIP-Seq_LS180_Human1.05333311
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05320735
85P53_22387025_ChIP-Seq_ESCs_Mouse1.05172633
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05071833
87IRF1_19129219_ChIP-ChIP_H3396_Human1.04786147
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04607556
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03252049
90JUN_21703547_ChIP-Seq_K562_Human1.03137114
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02387955
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01588127
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00072485
94HTT_18923047_ChIP-ChIP_STHdh_Human0.98780356
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97672616
96RNF2_27304074_Chip-Seq_ESCs_Mouse0.97342387
97SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97185229
98P300_18555785_Chip-Seq_ESCs_Mouse0.96445930
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.95563591
100EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95425392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002736_abnormal_nociception_after4.63907938
2MP0003880_abnormal_central_pattern3.66789068
3MP0004859_abnormal_synaptic_plasticity3.64994075
4MP0001968_abnormal_touch/_nociception3.62781693
5MP0005646_abnormal_pituitary_gland3.15473427
6MP0003315_abnormal_perineum_morphology3.08552949
7MP0005187_abnormal_penis_morphology3.06947545
8MP0002822_catalepsy2.92114977
9MP0002735_abnormal_chemical_nociception2.69202223
10MP0004270_analgesia2.63571240
11MP0000778_abnormal_nervous_system2.46313926
12MP0002102_abnormal_ear_morphology2.45513987
13MP0000569_abnormal_digit_pigmentation2.28363453
14MP0003635_abnormal_synaptic_transmissio2.22984633
15MP0003283_abnormal_digestive_organ2.16430892
16MP0003890_abnormal_embryonic-extraembry2.15255213
17MP0003011_delayed_dark_adaptation2.02525950
18MP0002272_abnormal_nervous_system2.01454056
19MP0010386_abnormal_urinary_bladder1.85585571
20MP0002734_abnormal_mechanical_nocicepti1.79783590
21MP0009745_abnormal_behavioral_response1.76843784
22MP0002184_abnormal_innervation1.76661623
23MP0000613_abnormal_salivary_gland1.75115921
24MP0006276_abnormal_autonomic_nervous1.73961193
25MP0002063_abnormal_learning/memory/cond1.72962138
26MP0003136_yellow_coat_color1.67243804
27MP0006292_abnormal_olfactory_placode1.61599171
28MP0003718_maternal_effect1.61057787
29MP0002751_abnormal_autonomic_nervous1.60958302
30MP0004133_heterotaxia1.58992252
31MP0001984_abnormal_olfaction1.58092405
32MP0002064_seizures1.56274009
33MP0003122_maternal_imprinting1.50869882
34MP0005551_abnormal_eye_electrophysiolog1.49655990
35MP0004811_abnormal_neuron_physiology1.46245050
36MP0001529_abnormal_vocalization1.46074100
37MP0003221_abnormal_cardiomyocyte_apopto1.45384744
38MP0002557_abnormal_social/conspecific_i1.43023540
39MP0002572_abnormal_emotion/affect_behav1.39096982
40MP0002909_abnormal_adrenal_gland1.38121305
41MP0005423_abnormal_somatic_nervous1.36495251
42MP0002733_abnormal_thermal_nociception1.33470575
43MP0000955_abnormal_spinal_cord1.32608535
44MP0001970_abnormal_pain_threshold1.31971031
45MP0004742_abnormal_vestibular_system1.30813586
46MP0002067_abnormal_sensory_capabilities1.28144553
47MP0008995_early_reproductive_senescence1.23971074
48MP0005499_abnormal_olfactory_system1.23152217
49MP0005394_taste/olfaction_phenotype1.23152217
50MP0000049_abnormal_middle_ear1.22334627
51MP0002882_abnormal_neuron_morphology1.22285672
52MP0002752_abnormal_somatic_nervous1.22232236
53MP0005253_abnormal_eye_physiology1.21804047
54MP0008058_abnormal_DNA_repair1.19024401
55MP0003567_abnormal_fetal_cardiomyocyte1.18789713
56MP0008872_abnormal_physiological_respon1.17570829
57MP0001764_abnormal_homeostasis1.17215115
58MP0002638_abnormal_pupillary_reflex1.16068900
59MP0003119_abnormal_digestive_system1.16019239
60MP0004885_abnormal_endolymph1.14971205
61MP0001486_abnormal_startle_reflex1.13680187
62MP0003121_genomic_imprinting1.13582336
63MP0000631_abnormal_neuroendocrine_gland1.07491606
64MP0004924_abnormal_behavior1.07037500
65MP0005386_behavior/neurological_phenoty1.07037500
66MP0002152_abnormal_brain_morphology1.01303271
67MP0005645_abnormal_hypothalamus_physiol1.00663558
68MP0003861_abnormal_nervous_system0.96926840
69MP0002234_abnormal_pharynx_morphology0.95505956
70MP0005084_abnormal_gallbladder_morpholo0.94905759
71MP0009046_muscle_twitch0.93942036
72MP0000751_myopathy0.91501892
73MP0001177_atelectasis0.87733007
74MP0000538_abnormal_urinary_bladder0.87604480
75MP0003937_abnormal_limbs/digits/tail_de0.87367301
76MP0002066_abnormal_motor_capabilities/c0.85416651
77MP0005195_abnormal_posterior_eye0.84599671
78MP0001485_abnormal_pinna_reflex0.83738776
79MP0002653_abnormal_ependyma_morphology0.83378222
80MP0000026_abnormal_inner_ear0.82555622
81MP0003942_abnormal_urinary_system0.81136270
82MP0008877_abnormal_DNA_methylation0.80781891
83MP0008789_abnormal_olfactory_epithelium0.79592708
84MP0006035_abnormal_mitochondrial_morpho0.79023422
85MP0008770_decreased_survivor_rate0.78737402
86MP0003950_abnormal_plasma_membrane0.77737368
87MP0003115_abnormal_respiratory_system0.77623505
88MP0003787_abnormal_imprinting0.76387903
89MP0002837_dystrophic_cardiac_calcinosis0.75758715
90MP0002233_abnormal_nose_morphology0.74795979
91MP0004142_abnormal_muscle_tone0.74715310
92MP0000516_abnormal_urinary_system0.73650147
93MP0005367_renal/urinary_system_phenotyp0.73650147
94MP0002127_abnormal_cardiovascular_syste0.70299919
95MP0005379_endocrine/exocrine_gland_phen0.69613743
96MP0001905_abnormal_dopamine_level0.69192985
97MP0003938_abnormal_ear_development0.68460734
98MP0001188_hyperpigmentation0.67625639
99MP0002210_abnormal_sex_determination0.67291424
100MP0003698_abnormal_male_reproductive0.64784148

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)6.03275089
2Focal motor seizures (HP:0011153)4.11389693
3Retinal dysplasia (HP:0007973)4.06875996
4Type II lissencephaly (HP:0007260)3.63102616
5Hyperventilation (HP:0002883)3.55957684
6Lissencephaly (HP:0001339)3.34807863
7Anosmia (HP:0000458)3.33048516
8Biliary tract neoplasm (HP:0100574)3.22816166
9Drooling (HP:0002307)3.20815467
10Focal seizures (HP:0007359)3.16921369
11Renal cortical cysts (HP:0000803)3.15007388
12Abnormality of midbrain morphology (HP:0002418)3.14523016
13Molar tooth sign on MRI (HP:0002419)3.14523016
14Pancreatic cysts (HP:0001737)3.11216057
15Broad-based gait (HP:0002136)3.09858072
16Inability to walk (HP:0002540)3.06652531
17Small hand (HP:0200055)3.05002026
18Excessive salivation (HP:0003781)2.95457742
19Pancreatic fibrosis (HP:0100732)2.88116078
20True hermaphroditism (HP:0010459)2.87926292
21Progressive inability to walk (HP:0002505)2.86247948
22Aplasia/Hypoplasia of the brainstem (HP:0007362)2.86010929
23Hypoplasia of the brainstem (HP:0002365)2.86010929
24Polyphagia (HP:0002591)2.79786714
25Aplasia/Hypoplasia of the tibia (HP:0005772)2.78354396
26Hypoplastic pelvis (HP:0008839)2.64898741
27Pachygyria (HP:0001302)2.63513337
28Abnormality of the astrocytes (HP:0100707)2.45241642
29Astrocytoma (HP:0009592)2.45241642
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.43428011
31Intestinal atresia (HP:0011100)2.42818834
32Absent speech (HP:0001344)2.40997433
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.39191790
34Partial agenesis of the corpus callosum (HP:0001338)2.39165536
35Generalized tonic-clonic seizures (HP:0002069)2.38494661
36Abnormal eating behavior (HP:0100738)2.37801094
37Megalencephaly (HP:0001355)2.35234380
38Medial flaring of the eyebrow (HP:0010747)2.27437404
39Abnormality of salivation (HP:0100755)2.26837740
40Fibular aplasia (HP:0002990)2.26689667
41Polymicrogyria (HP:0002126)2.25899166
42Spastic tetraplegia (HP:0002510)2.24712217
43Optic nerve hypoplasia (HP:0000609)2.22837077
44Ependymoma (HP:0002888)2.22400450
45Short tibia (HP:0005736)2.21941687
46Gait imbalance (HP:0002141)2.17076256
47Neoplasm of the small intestine (HP:0100833)2.15101122
48Hypogonadotrophic hypogonadism (HP:0000044)2.12743393
49Cortical dysplasia (HP:0002539)2.12432077
50Nephronophthisis (HP:0000090)2.12098118
51Absent/shortened dynein arms (HP:0200106)2.11603864
52Dynein arm defect of respiratory motile cilia (HP:0012255)2.11603864
53Delayed puberty (HP:0000823)2.07010562
54Abnormality of the renal cortex (HP:0011035)2.05895587
55Narrow forehead (HP:0000341)2.05871558
56Congenital primary aphakia (HP:0007707)2.05792087
57Anterior segment dysgenesis (HP:0007700)2.04703161
58Oligodactyly (hands) (HP:0001180)2.03395654
59Anencephaly (HP:0002323)2.03050841
60Tented upper lip vermilion (HP:0010804)2.02912761
61Hypoplasia of the pons (HP:0012110)2.00659655
62Neoplasm of the rectum (HP:0100743)1.99974781
63Hypothermia (HP:0002045)1.99902896
64Hemiparesis (HP:0001269)1.98886900
65Abnormality of the labia minora (HP:0012880)1.98585707
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98251663
67Colon cancer (HP:0003003)1.98139909
68Nephrogenic diabetes insipidus (HP:0009806)1.97717401
69Abnormality of the aortic arch (HP:0012303)1.95516934
70Abnormality of glycolysis (HP:0004366)1.94948286
71Genital tract atresia (HP:0001827)1.92659480
72Long clavicles (HP:0000890)1.89667841
73Progressive cerebellar ataxia (HP:0002073)1.88676053
74Short foot (HP:0001773)1.86969064
75Febrile seizures (HP:0002373)1.85898114
76Chronic hepatic failure (HP:0100626)1.85700971
77Atonic seizures (HP:0010819)1.84634915
78Postaxial hand polydactyly (HP:0001162)1.84040145
79Papilledema (HP:0001085)1.82879023
80Protruding tongue (HP:0010808)1.82636638
81Proximal tubulopathy (HP:0000114)1.81485687
82Abnormal auditory evoked potentials (HP:0006958)1.80525199
83Increased serum pyruvate (HP:0003542)1.77766400
84Truncal ataxia (HP:0002078)1.77615901
85Tubulointerstitial fibrosis (HP:0005576)1.77420425
86Glioma (HP:0009733)1.77013930
87Synostosis involving the elbow (HP:0003938)1.76849006
88Humeroradial synostosis (HP:0003041)1.76849006
89Labial hypoplasia (HP:0000066)1.75862049
90Agnosia (HP:0010524)1.75331382
91Prominent supraorbital ridges (HP:0000336)1.75313509
92Micropenis (HP:0000054)1.73940852
93Exotropia (HP:0000577)1.73465924
94Cupped ear (HP:0000378)1.72379998
95Postaxial foot polydactyly (HP:0001830)1.72321282
96Esotropia (HP:0000565)1.71650474
97Fetal akinesia sequence (HP:0001989)1.70005026
98Myokymia (HP:0002411)1.69480627
99Oligodactyly (HP:0012165)1.69294514
100Capillary hemangiomas (HP:0005306)1.68606590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK17.91452607
2CASK4.20297392
3NTRK33.56138538
4MARK13.01468880
5NEK22.95974802
6DYRK32.77064979
7PLK42.31072738
8FRK2.26797438
9UHMK12.03602825
10MAPK132.00775322
11MKNK21.89090450
12MAP3K41.82731219
13RPS6KA41.76767235
14TRIM281.72770421
15MINK11.70150828
16WNK31.60326830
17ACVR1B1.55777979
18VRK11.51373339
19SRPK11.45712072
20DYRK21.37424012
21CAMK2B1.36641545
22BCR1.35526865
23ERBB31.29602395
24TNIK1.29077381
25EPHA41.26306638
26BMPR1B1.26056109
27PLK21.24596651
28MAP2K71.22950864
29YES11.17161321
30SIK21.15958768
31CAMKK21.12332160
32CAMK41.00632828
33NTRK20.98742623
34SIK30.98623631
35MKNK10.98147198
36MAP4K20.98075344
37BRD40.98028994
38PIK3CA0.95225333
39CDC70.95127582
40PRKCG0.92006076
41ADRBK20.88756331
42CAMK2A0.84931286
43BCKDK0.83149006
44CSNK1G20.80325366
45STK160.77122858
46SGK20.75715666
47CDK180.72664604
48MAPKAPK50.68945292
49LATS10.68557023
50EPHB10.68259655
51MAP2K40.66861362
52ROCK20.65079921
53CDK150.63778866
54PLK30.63362587
55OXSR10.62456558
56MST40.61897950
57MAPK150.59737691
58CDK140.59349038
59BRSK20.57815746
60SGK4940.57305119
61SGK2230.57305119
62CSNK1A10.56240087
63CCNB10.54228888
64TSSK60.54120381
65PRKCE0.52885029
66PAK30.52211379
67CSNK1G30.51092446
68CAMK2G0.50804832
69CDK11A0.50498075
70CSNK1G10.49724311
71RPS6KB20.49666845
72PRKACB0.48848789
73NUAK10.48713490
74CAMK2D0.48456300
75CSNK1A1L0.48232558
76RPS6KB10.47604699
77RPS6KA50.46537137
78GRK10.45340179
79TGFBR10.44088576
80EPHB20.43470208
81CDK50.42347325
82TYRO30.39899368
83DAPK10.38805708
84MAPK100.36491170
85PRKCZ0.36467784
86DYRK1A0.36394160
87PDGFRA0.34625972
88PRKG10.34153287
89DYRK1B0.33795025
90FGR0.33693175
91EGFR0.33507481
92PRKCB0.33057172
93INSRR0.32293522
94ATM0.31514331
95GSK3A0.30608126
96BUB10.29572489
97DAPK20.29523721
98OBSCN0.29471363
99PRKACA0.29122277
100PRKCH0.28887033

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.22712568
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.79716257
3Steroid biosynthesis_Homo sapiens_hsa001003.28220156
4Caffeine metabolism_Homo sapiens_hsa002323.19714681
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.66822432
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.29682848
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.27877874
8Cocaine addiction_Homo sapiens_hsa050302.24505310
9Amphetamine addiction_Homo sapiens_hsa050312.21032582
10Propanoate metabolism_Homo sapiens_hsa006402.20695238
11Mismatch repair_Homo sapiens_hsa034302.13712732
12Taste transduction_Homo sapiens_hsa047422.02550882
13Basal transcription factors_Homo sapiens_hsa030222.02172382
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99063042
15Butanoate metabolism_Homo sapiens_hsa006501.96857292
16Glutamatergic synapse_Homo sapiens_hsa047241.95748066
17Circadian entrainment_Homo sapiens_hsa047131.93515775
18Dopaminergic synapse_Homo sapiens_hsa047281.93023311
19Phototransduction_Homo sapiens_hsa047441.72646469
20Morphine addiction_Homo sapiens_hsa050321.70511195
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64444873
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55744841
23GABAergic synapse_Homo sapiens_hsa047271.51523948
24Long-term depression_Homo sapiens_hsa047301.43616463
25Axon guidance_Homo sapiens_hsa043601.42925093
26Protein export_Homo sapiens_hsa030601.33395487
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26075013
28Non-homologous end-joining_Homo sapiens_hsa034501.25854639
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21715348
30Synaptic vesicle cycle_Homo sapiens_hsa047211.20181425
31Linoleic acid metabolism_Homo sapiens_hsa005911.16438023
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15712112
33Ether lipid metabolism_Homo sapiens_hsa005651.07231254
34Fanconi anemia pathway_Homo sapiens_hsa034601.06262626
35Insulin secretion_Homo sapiens_hsa049111.04488287
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04192466
37cAMP signaling pathway_Homo sapiens_hsa040241.01489327
38Basal cell carcinoma_Homo sapiens_hsa052171.01312555
39Cholinergic synapse_Homo sapiens_hsa047251.00672438
40Hedgehog signaling pathway_Homo sapiens_hsa043400.99555457
41Arginine and proline metabolism_Homo sapiens_hsa003300.94581999
42Renin secretion_Homo sapiens_hsa049240.92127914
43Tryptophan metabolism_Homo sapiens_hsa003800.86042113
44Peroxisome_Homo sapiens_hsa041460.83726169
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83306100
46Vitamin B6 metabolism_Homo sapiens_hsa007500.82360210
47Gastric acid secretion_Homo sapiens_hsa049710.81147644
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80302333
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.79505753
50Selenocompound metabolism_Homo sapiens_hsa004500.77458214
51Alcoholism_Homo sapiens_hsa050340.76964652
52Nucleotide excision repair_Homo sapiens_hsa034200.75132321
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74110017
54Histidine metabolism_Homo sapiens_hsa003400.71715576
55Fatty acid metabolism_Homo sapiens_hsa012120.68583564
56Cardiac muscle contraction_Homo sapiens_hsa042600.68417778
57Retinol metabolism_Homo sapiens_hsa008300.66410493
58Olfactory transduction_Homo sapiens_hsa047400.64657145
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64172016
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63750464
61Collecting duct acid secretion_Homo sapiens_hsa049660.63418852
62Salivary secretion_Homo sapiens_hsa049700.62364083
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62088590
64mRNA surveillance pathway_Homo sapiens_hsa030150.61748486
65Fatty acid degradation_Homo sapiens_hsa000710.61356476
66Oxidative phosphorylation_Homo sapiens_hsa001900.60674937
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.60507886
68Fatty acid biosynthesis_Homo sapiens_hsa000610.60378066
69Regulation of autophagy_Homo sapiens_hsa041400.59334022
70Gap junction_Homo sapiens_hsa045400.54962009
71Parkinsons disease_Homo sapiens_hsa050120.54710332
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51011776
73TGF-beta signaling pathway_Homo sapiens_hsa043500.50557507
74Glycerolipid metabolism_Homo sapiens_hsa005610.49561096
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.47834409
76Wnt signaling pathway_Homo sapiens_hsa043100.46757063
77beta-Alanine metabolism_Homo sapiens_hsa004100.45851256
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45531144
79Calcium signaling pathway_Homo sapiens_hsa040200.44869264
80Long-term potentiation_Homo sapiens_hsa047200.44404013
81GnRH signaling pathway_Homo sapiens_hsa049120.43841598
82Estrogen signaling pathway_Homo sapiens_hsa049150.43707637
83Serotonergic synapse_Homo sapiens_hsa047260.43687594
84RNA transport_Homo sapiens_hsa030130.43326410
85Hippo signaling pathway_Homo sapiens_hsa043900.42753662
86Fat digestion and absorption_Homo sapiens_hsa049750.40811720
87Chemical carcinogenesis_Homo sapiens_hsa052040.40784391
88Dorso-ventral axis formation_Homo sapiens_hsa043200.40064037
89Melanogenesis_Homo sapiens_hsa049160.39006365
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38151305
91Huntingtons disease_Homo sapiens_hsa050160.37885622
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37220372
93Tight junction_Homo sapiens_hsa045300.36789406
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36277885
95Fatty acid elongation_Homo sapiens_hsa000620.36165484
96Oocyte meiosis_Homo sapiens_hsa041140.34853427
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34822211
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33199132
99Purine metabolism_Homo sapiens_hsa002300.31052019
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30172640

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