HSH2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.21686665
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.21686665
3antigen processing and presentation of endogenous antigen (GO:0019883)5.82602849
4positive regulation of gamma-delta T cell activation (GO:0046645)5.40658490
5ribosomal small subunit assembly (GO:0000028)5.37220126
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.09761394
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.89314034
8positive regulation by symbiont of host defense response (GO:0052509)4.74270914
9modulation by symbiont of host defense response (GO:0052031)4.74270914
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.74270914
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.74270914
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.74270914
13modulation by symbiont of host immune response (GO:0052553)4.74270914
14regulation of B cell receptor signaling pathway (GO:0050855)4.35324739
15detection of bacterium (GO:0016045)4.30329565
16DNA deamination (GO:0045006)4.29129264
17detection of other organism (GO:0098543)4.28196966
18response to peptidoglycan (GO:0032494)4.23895642
19regulation of gamma-delta T cell differentiation (GO:0045586)4.14321709
20viral transcription (GO:0019083)4.13984253
21antigen processing and presentation via MHC class Ib (GO:0002475)4.07872695
22negative thymic T cell selection (GO:0045060)4.05645238
23negative T cell selection (GO:0043383)4.02399783
24macrophage activation involved in immune response (GO:0002281)3.99343469
25NIK/NF-kappaB signaling (GO:0038061)3.98729578
26translational termination (GO:0006415)3.98066840
27response to type I interferon (GO:0034340)3.91069900
28cellular response to type I interferon (GO:0071357)3.91005276
29type I interferon signaling pathway (GO:0060337)3.91005276
30response to interleukin-15 (GO:0070672)3.88899627
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.87579953
32regulation of B cell differentiation (GO:0045577)3.86523297
33cellular extravasation (GO:0045123)3.84911859
34leukocyte aggregation (GO:0070486)3.84412319
35regulation of gamma-delta T cell activation (GO:0046643)3.80751410
36positive regulation of B cell differentiation (GO:0045579)3.80134668
37B cell receptor signaling pathway (GO:0050853)3.75517850
38negative regulation of cell killing (GO:0031342)3.67268565
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.67268565
40negative regulation of T cell mediated immunity (GO:0002710)3.66832371
41regulation of interferon-beta biosynthetic process (GO:0045357)3.66107296
42response to interferon-beta (GO:0035456)3.66092612
43neutrophil activation (GO:0042119)3.64623777
44negative regulation of interleukin-12 production (GO:0032695)3.61092904
45cellular response to interleukin-15 (GO:0071350)3.60610807
46ribosomal small subunit biogenesis (GO:0042274)3.55109180
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.53246522
48response to host immune response (GO:0052572)3.53246522
49T cell migration (GO:0072678)3.51540065
50negative regulation of leukocyte mediated immunity (GO:0002704)3.51127569
51response to muramyl dipeptide (GO:0032495)3.49332306
52respiratory burst (GO:0045730)3.48623391
53positive thymic T cell selection (GO:0045059)3.48217944
54translational elongation (GO:0006414)3.47823742
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.40822439
56myeloid cell activation involved in immune response (GO:0002275)3.40772594
57cellular response to interferon-beta (GO:0035458)3.40316767
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38842869
59microglial cell activation (GO:0001774)3.38204353
60detection of external biotic stimulus (GO:0098581)3.36622832
61regulation of mast cell degranulation (GO:0043304)3.34463306
62positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.32141394
63negative regulation of erythrocyte differentiation (GO:0045647)3.30746213
64T cell homeostasis (GO:0043029)3.30297797
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.29390144
66cotranslational protein targeting to membrane (GO:0006613)3.28918814
67protein targeting to ER (GO:0045047)3.28186243
68regulation of T cell receptor signaling pathway (GO:0050856)3.23369458
69interferon-gamma-mediated signaling pathway (GO:0060333)3.22780743
70positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.20973654
71neutrophil mediated immunity (GO:0002446)3.20505319
72granulocyte activation (GO:0036230)3.20039498
73leukocyte degranulation (GO:0043299)3.18594987
74positive regulation of interferon-alpha production (GO:0032727)3.17476463
75regulation of antigen processing and presentation (GO:0002577)3.17462401
76thymic T cell selection (GO:0045061)3.16043385
77defense response to protozoan (GO:0042832)3.15944654
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15625589
79response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.15295840
80response to host (GO:0075136)3.15295840
81response to host defenses (GO:0052200)3.15295840
82cellular response to zinc ion (GO:0071294)3.14659344
83regulation of myeloid leukocyte mediated immunity (GO:0002886)3.14138601
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12914429
85protein localization to endoplasmic reticulum (GO:0070972)3.12861124
86regulation of dendritic cell antigen processing and presentation (GO:0002604)3.12795781
87maturation of SSU-rRNA (GO:0030490)3.12632422
88regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.12567280
89establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11123162
90regulation of mast cell activation involved in immune response (GO:0033006)3.10166088
91germinal center formation (GO:0002467)3.09113835
92regulation of mast cell activation (GO:0033003)3.06934098
93Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06414865
94regulation of type I interferon-mediated signaling pathway (GO:0060338)3.06365070
95positive regulation of antigen processing and presentation (GO:0002579)3.06264867
96viral life cycle (GO:0019058)3.05935652
97immunoglobulin mediated immune response (GO:0016064)3.05552902
98response to protozoan (GO:0001562)3.04360228
99interferon-gamma production (GO:0032609)3.03871336
100positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.02438237
101cellular protein complex disassembly (GO:0043624)3.02128843
102negative regulation of innate immune response (GO:0045824)3.00769236
103regulation of interferon-alpha production (GO:0032647)3.00437276
104detection of biotic stimulus (GO:0009595)2.98867065
105regulation of interleukin-12 biosynthetic process (GO:0045075)2.97404670
106mast cell activation (GO:0045576)2.97364564
107regulation of leukocyte degranulation (GO:0043300)2.95826575
108macrophage activation (GO:0042116)2.95192340
109antigen receptor-mediated signaling pathway (GO:0050851)2.95172723
110positive regulation of mast cell activation (GO:0033005)2.94659188
111mature B cell differentiation (GO:0002335)2.94393780
112myeloid dendritic cell activation (GO:0001773)2.93875179
113T cell selection (GO:0045058)2.93470756
114telomere maintenance via semi-conservative replication (GO:0032201)2.93330057
115regulation of alpha-beta T cell proliferation (GO:0046640)2.92333104
116tolerance induction (GO:0002507)2.88106665
117regulation of response to interferon-gamma (GO:0060330)2.87387158
118regulation of tolerance induction (GO:0002643)2.87021769
119B cell homeostasis (GO:0001782)2.86430180
120negative regulation of interleukin-6 production (GO:0032715)2.86366240
121B cell mediated immunity (GO:0019724)2.85756008
122Peyers patch development (GO:0048541)2.84657284
123mucosal-associated lymphoid tissue development (GO:0048537)2.84657284
124translational initiation (GO:0006413)2.84456163
125definitive hemopoiesis (GO:0060216)2.80943899
126lymph node development (GO:0048535)2.78044781
127regulation of isotype switching to IgG isotypes (GO:0048302)2.77810320
128response to interferon-alpha (GO:0035455)2.77484835
129lymphocyte homeostasis (GO:0002260)2.75586193
130regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.75441614
131positive T cell selection (GO:0043368)2.73828516
132negative regulation of phagocytosis (GO:0050765)2.73250051
133regulation of T cell mediated cytotoxicity (GO:0001914)2.70314907
134T cell receptor signaling pathway (GO:0050852)2.68906611
135mature B cell differentiation involved in immune response (GO:0002313)2.68749496
136protein complex disassembly (GO:0043241)2.68654006
137negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.68290997
138DNA strand elongation involved in DNA replication (GO:0006271)2.68262882
139regulation of necroptotic process (GO:0060544)2.67739030
140neutrophil activation involved in immune response (GO:0002283)2.65535949
141necroptotic process (GO:0070266)2.65089513
142regulation of RIG-I signaling pathway (GO:0039535)2.64931225
143platelet dense granule organization (GO:0060155)2.64509837
144T cell costimulation (GO:0031295)2.62954005
145leukocyte homeostasis (GO:0001776)2.62747273
146lymphocyte costimulation (GO:0031294)2.62512829
147DNA strand elongation (GO:0022616)2.62446381
148positive regulation of T cell mediated cytotoxicity (GO:0001916)2.62243068
149positive regulation of granulocyte differentiation (GO:0030854)2.58342410
150positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57332659
151telomere maintenance via recombination (GO:0000722)2.57211778
152myeloid dendritic cell differentiation (GO:0043011)2.56150925
153positive regulation of alpha-beta T cell proliferation (GO:0046641)2.53249335
154JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.51519062
155nuclear-transcribed mRNA catabolic process (GO:0000956)2.50628978

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.40242195
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.57782102
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.95293795
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.37895324
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23414289
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14788722
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.11521586
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.01374936
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.82478754
10MYC_22102868_ChIP-Seq_BL_Human2.80990990
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79501279
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.78902643
13SCL_19346495_ChIP-Seq_HPC-7_Human2.60067507
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.56886424
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.51574421
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45399403
17* VDR_21846776_ChIP-Seq_THP-1_Human2.32590451
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.30353675
19* MYB_26560356_Chip-Seq_TH2_Human2.28348013
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26534791
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.25282003
22SPI1_23547873_ChIP-Seq_NB4_Human2.22043636
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.21575134
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12475490
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11338813
26MAF_26560356_Chip-Seq_TH1_Human2.09937547
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.09455402
28MYB_26560356_Chip-Seq_TH1_Human2.03553487
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.02996676
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98986440
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97887760
32SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.91059473
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89993997
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.88808529
35VDR_23849224_ChIP-Seq_CD4+_Human1.86248033
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83410436
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82889737
38* UTX_26944678_Chip-Seq_JUKART_Human1.82838475
39* VDR_24763502_ChIP-Seq_THP-1_Human1.82276966
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.78127915
41RUNX_20019798_ChIP-Seq_JUKART_Human1.77134375
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76876289
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76589227
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.72295315
45FOXP3_21729870_ChIP-Seq_TREG_Human1.68414659
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.66990244
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65536367
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.65069949
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63402978
50GATA1_22025678_ChIP-Seq_K562_Human1.61997251
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57000379
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.56393942
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54860590
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54528818
55* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52940534
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52526563
57VDR_24787735_ChIP-Seq_THP-1_Human1.52292570
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50646230
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.49476202
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49049166
61MAF_26560356_Chip-Seq_TH2_Human1.46281844
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45936269
63CIITA_25753668_ChIP-Seq_RAJI_Human1.43242745
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.42997130
65KDM2B_26808549_Chip-Seq_DND41_Human1.42311742
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41491142
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41146158
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41024880
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39687020
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39265821
71XRN2_22483619_ChIP-Seq_HELA_Human1.39034576
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38240058
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.36879949
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34855746
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32024537
76TCF7_22412390_ChIP-Seq_EML_Mouse1.31223621
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29923717
78BCL6_27268052_Chip-Seq_Bcells_Human1.28424308
79GATA3_27048872_Chip-Seq_THYMUS_Human1.28396882
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.27707816
81SPI1_23127762_ChIP-Seq_K562_Human1.19834904
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19537927
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17468495
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16019707
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15578955
86BCOR_27268052_Chip-Seq_Bcells_Human1.12921112
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12538567
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12328370
89GABP_19822575_ChIP-Seq_HepG2_Human1.11464080
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.11270093
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09019076
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.08881901
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08790536
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08644853
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08354443
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05562695
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05249835
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05198415
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03793565
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.03572137
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03075066
102GATA1_19941826_ChIP-Seq_K562_Human1.02809262
103RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02740784
104ELK1_19687146_ChIP-ChIP_HELA_Human1.02650445
105GATA3_26560356_Chip-Seq_TH2_Human1.02635871
106PU_27001747_Chip-Seq_BMDM_Mouse1.02036485
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01582862
108NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00671714
109IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99714372
110DCP1A_22483619_ChIP-Seq_HELA_Human0.99394536
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98694160
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98532942
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98108315
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97207315
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97131705
116* P300_27268052_Chip-Seq_Bcells_Human0.96495874
117E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96333066
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95820367
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92360530
120MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92357673
121CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92138472
122SPI1_20517297_ChIP-Seq_HL60_Human0.92007091
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91918761
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.91449595
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91220235
126KDM5A_27292631_Chip-Seq_BREAST_Human0.90839520
127ELK3_25401928_ChIP-Seq_HUVEC_Human0.90770660
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90692533
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90280487
130NCOR1_26117541_ChIP-Seq_K562_Human0.88926312
131CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86960072
132EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86959393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.52010080
2MP0000685_abnormal_immune_system3.73041311
3MP0002396_abnormal_hematopoietic_system3.61721410
4MP0005671_abnormal_response_to3.60934367
5MP0003763_abnormal_thymus_physiology3.38709673
6MP0009785_altered_susceptibility_to3.37359119
7MP0001800_abnormal_humoral_immune3.22222393
8MP0005387_immune_system_phenotype2.98240362
9MP0001790_abnormal_immune_system2.98240362
10MP0002166_altered_tumor_susceptibility2.92896515
11MP0005025_abnormal_response_to2.76072454
12MP0002452_abnormal_antigen_presenting2.76011287
13MP0005000_abnormal_immune_tolerance2.74435389
14* MP0002723_abnormal_immune_serum2.72704271
15* MP0002420_abnormal_adaptive_immunity2.71276647
16* MP0002398_abnormal_bone_marrow2.71215315
17* MP0001819_abnormal_immune_cell2.68086253
18MP0003436_decreased_susceptibility_to2.52277072
19MP0002148_abnormal_hypersensitivity_rea2.41971592
20MP0002006_tumorigenesis2.38727489
21* MP0000716_abnormal_immune_system2.37707917
22MP0002419_abnormal_innate_immunity2.23457557
23MP0001853_heart_inflammation2.21124319
24MP0004808_abnormal_hematopoietic_stem2.20635602
25* MP0000689_abnormal_spleen_morphology2.19606623
26MP0002405_respiratory_system_inflammati2.15840390
27* MP0002722_abnormal_immune_system2.11712494
28MP0001873_stomach_inflammation2.07796379
29MP0005397_hematopoietic_system_phenotyp2.05638219
30MP0001545_abnormal_hematopoietic_system2.05638219
31* MP0002429_abnormal_blood_cell2.05460935
32MP0003724_increased_susceptibility_to2.02092875
33MP0009333_abnormal_splenocyte_physiolog2.00744549
34MP0005464_abnormal_platelet_physiology1.98473076
35MP0010155_abnormal_intestine_physiology1.93279642
36MP0000703_abnormal_thymus_morphology1.84667901
37MP0003866_abnormal_defecation1.81530814
38MP0003693_abnormal_embryo_hatching1.77047121
39MP0008057_abnormal_DNA_replication1.69166025
40MP0001845_abnormal_inflammatory_respons1.64410924
41MP0010094_abnormal_chromosome_stability1.62941949
42MP0000490_abnormal_crypts_of1.58170719
43MP0004947_skin_inflammation1.56775496
44MP0006082_CNS_inflammation1.55510136
45MP0008058_abnormal_DNA_repair1.54644191
46MP0000465_gastrointestinal_hemorrhage1.49845819
47MP0003303_peritoneal_inflammation1.49142362
48MP0005174_abnormal_tail_pigmentation1.48841414
49MP0005310_abnormal_salivary_gland1.44521808
50MP0004510_myositis1.42716036
51MP0009278_abnormal_bone_marrow1.40341916
52MP0003077_abnormal_cell_cycle1.37713422
53MP0005075_abnormal_melanosome_morpholog1.33665056
54MP0008469_abnormal_protein_level1.30470278
55MP0002019_abnormal_tumor_incidence1.28973070
56MP0000858_altered_metastatic_potential1.24669847
57MP0002933_joint_inflammation1.23130578
58MP0008260_abnormal_autophagy1.15320025
59MP0003111_abnormal_nucleus_morphology1.11497687
60MP0002095_abnormal_skin_pigmentation1.11294384
61MP0002009_preneoplasia1.10592987
62MP0008007_abnormal_cellular_replicative1.05274522
63MP0001533_abnormal_skeleton_physiology1.03904539
64MP0004957_abnormal_blastocyst_morpholog1.03136435
65MP0002277_abnormal_respiratory_mucosa1.00941993
66MP0003806_abnormal_nucleotide_metabolis0.98450227
67MP0003300_gastrointestinal_ulcer0.95610952
68MP0005451_abnormal_body_composition0.95218078
69MP0002132_abnormal_respiratory_system0.89826813
70MP0001348_abnormal_lacrimal_gland0.89602097
71MP0003448_altered_tumor_morphology0.87686521
72MP0002138_abnormal_hepatobiliary_system0.86540106
73MP0000313_abnormal_cell_death0.82994791
74MP0004883_abnormal_blood_vessel0.81780451
75MP0006054_spinal_hemorrhage0.80435971
76MP0003191_abnormal_cellular_cholesterol0.79179374
77MP0003075_altered_response_to0.78272280
78MP0010352_gastrointestinal_tract_polyps0.75154232
79MP0009764_decreased_sensitivity_to0.75086852
80MP0003045_fibrosis0.74350901
81MP0000343_altered_response_to0.73730001
82MP0010307_abnormal_tumor_latency0.73362263
83MP0003786_premature_aging0.70534128
84MP0003172_abnormal_lysosome_physiology0.69802768
85MP0009763_increased_sensitivity_to0.69215186
86MP0005390_skeleton_phenotype0.69066710
87MP0000015_abnormal_ear_pigmentation0.68850615
88MP0003656_abnormal_erythrocyte_physiolo0.68695778
89MP0002693_abnormal_pancreas_physiology0.64126224
90MP0005058_abnormal_lysosome_morphology0.63492625
91MP0001663_abnormal_digestive_system0.63042047
92MP0005164_abnormal_response_to0.62124729
93MP0008873_increased_physiological_sensi0.61798506
94MP0003943_abnormal_hepatobiliary_system0.60383397
95MP0002928_abnormal_bile_duct0.59215974
96MP0000350_abnormal_cell_proliferation0.59049491
97MP0000477_abnormal_intestine_morphology0.58685912
98MP0003186_abnormal_redox_activity0.57945057
99MP0005023_abnormal_wound_healing0.57609329
100MP0003252_abnormal_bile_duct0.56407961
101MP0009765_abnormal_xenobiotic_induced0.55772009
102MP0005319_abnormal_enzyme/_coenzyme0.55273779
103MP0003828_pulmonary_edema0.54653140
104MP0003787_abnormal_imprinting0.54031434
105MP0001986_abnormal_taste_sensitivity0.53830146
106MP0000371_diluted_coat_color0.53179494
107MP0000249_abnormal_blood_vessel0.52817039
108MP0001191_abnormal_skin_condition0.51934254
109MP0008874_decreased_physiological_sensi0.50697210
110MP0001851_eye_inflammation0.49533941
111MP0003183_abnormal_peptide_metabolism0.48739597
112MP0008961_abnormal_basal_metabolism0.47948626
113MP0002998_abnormal_bone_remodeling0.47613220
114MP0005084_abnormal_gallbladder_morpholo0.47284289
115MP0003795_abnormal_bone_structure0.47114282
116MP0005166_decreased_susceptibility_to0.46996190
117MP0006036_abnormal_mitochondrial_physio0.46500760
118MP0004381_abnormal_hair_follicle0.45854919
119MP0005535_abnormal_body_temperature0.45647368
120MP0001764_abnormal_homeostasis0.44386450
121MP0002136_abnormal_kidney_physiology0.44250547
122MP0002163_abnormal_gland_morphology0.43960540
123MP0000609_abnormal_liver_physiology0.43888367
124MP0009379_abnormal_foot_pigmentation0.42773532
125MP0005381_digestive/alimentary_phenotyp0.42213404
126MP0005376_homeostasis/metabolism_phenot0.41996978
127MP0009642_abnormal_blood_homeostasis0.41648485

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)5.12341272
2Elevated erythrocyte sedimentation rate (HP:0003565)4.81641433
3IgM deficiency (HP:0002850)4.81290549
4Recurrent bronchitis (HP:0002837)4.78226574
5Thrombocytosis (HP:0001894)4.48231968
6Recurrent viral infections (HP:0004429)4.38656393
7Recurrent abscess formation (HP:0002722)4.19608687
8Panhypogammaglobulinemia (HP:0003139)4.14918946
9Recurrent fungal infections (HP:0002841)4.12703566
10Myositis (HP:0100614)4.10674460
11Agammaglobulinemia (HP:0004432)4.02081504
12Abnormality of T cells (HP:0002843)3.83836135
13Nasal polyposis (HP:0100582)3.77608677
14Severe combined immunodeficiency (HP:0004430)3.74535894
15T lymphocytopenia (HP:0005403)3.73497129
16Eczematoid dermatitis (HP:0000976)3.73190177
17Abnormality of T cell number (HP:0011839)3.71010050
18Abnormality of T cell physiology (HP:0011840)3.66984019
19IgG deficiency (HP:0004315)3.63396124
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.63180378
21Recurrent bacterial skin infections (HP:0005406)3.61764772
22Gastrointestinal infarctions (HP:0005244)3.58013446
23Abnormality of cells of the erythroid lineage (HP:0012130)3.56148813
24Abnormal number of erythroid precursors (HP:0012131)3.53049689
25Thyroiditis (HP:0100646)3.52812370
26Abnormality of B cell number (HP:0010975)3.49156837
27B lymphocytopenia (HP:0010976)3.49156837
28Chronic mucocutaneous candidiasis (HP:0002728)3.48626734
29Recurrent cutaneous fungal infections (HP:0011370)3.48626734
30Meningitis (HP:0001287)3.45055000
31Combined immunodeficiency (HP:0005387)3.41067676
32Lymphopenia (HP:0001888)3.33484859
33Chest pain (HP:0100749)3.32579206
34Abnormality of the nasal mucosa (HP:0000433)3.28096141
35Cellulitis (HP:0100658)3.26218021
36Abnormality of cells of the lymphoid lineage (HP:0012140)3.25784360
37Urticaria (HP:0001025)3.24026081
38Hypochromic microcytic anemia (HP:0004840)3.23587203
39Reticulocytopenia (HP:0001896)3.21969503
40Hypochromic anemia (HP:0001931)3.20774815
41Gastrointestinal inflammation (HP:0004386)3.07547338
42Inflammation of the large intestine (HP:0002037)3.07261773
43Recurrent skin infections (HP:0001581)3.06128906
44Petechiae (HP:0000967)3.04309849
45Mediastinal lymphadenopathy (HP:0100721)3.03190894
46Prolonged bleeding time (HP:0003010)2.96425868
47Vasculitis (HP:0002633)2.95799929
48Keratoconjunctivitis (HP:0001096)2.90454866
49Recurrent sinusitis (HP:0011108)2.88366778
50Retrobulbar optic neuritis (HP:0100654)2.87405255
51Optic neuritis (HP:0100653)2.87405255
52Gastrointestinal stroma tumor (HP:0100723)2.85694423
53Aplastic anemia (HP:0001915)2.84617618
54Chronic sinusitis (HP:0011109)2.84179408
55Colitis (HP:0002583)2.81841124
56Lymphoma (HP:0002665)2.78582668
57Hypoplasia of the thymus (HP:0000778)2.78163672
58Chronic diarrhea (HP:0002028)2.73164568
59Orchitis (HP:0100796)2.72370711
60Osteomyelitis (HP:0002754)2.72355976
61Obstructive lung disease (HP:0006536)2.71579644
62Chronic obstructive pulmonary disease (HP:0006510)2.71579644
63Abnormality of eosinophils (HP:0001879)2.70339791
64Bronchitis (HP:0012387)2.70170725
65Gingivitis (HP:0000230)2.69434885
66Pustule (HP:0200039)2.67462994
67IgA deficiency (HP:0002720)2.66806060
68Encephalitis (HP:0002383)2.66638249
69Stomatitis (HP:0010280)2.66012535
70Granulocytopenia (HP:0001913)2.61665623
71Autoimmune thrombocytopenia (HP:0001973)2.59014299
72Leukocytosis (HP:0001974)2.58159087
73Eosinophilia (HP:0001880)2.56028560
74Autoimmune hemolytic anemia (HP:0001890)2.55768519
75Poikiloderma (HP:0001029)2.53996510
76Abnormality of the pleura (HP:0002103)2.49747705
77Viral hepatitis (HP:0006562)2.49536966
78Abnormality of macrophages (HP:0004311)2.48845655
79Increased IgE level (HP:0003212)2.48605335
80Impaired platelet aggregation (HP:0003540)2.48432435
81Abnormal platelet function (HP:0011869)2.48432435
82Epistaxis (HP:0000421)2.46351533
83Gingival bleeding (HP:0000225)2.46033162
84Verrucae (HP:0200043)2.45814059
85Papilloma (HP:0012740)2.45814059
86Pallor (HP:0000980)2.45590792
87Pulmonary embolism (HP:0002204)2.45443791
88Hypergammaglobulinemia (HP:0010702)2.44701126
89Abnormality of the fingertips (HP:0001211)2.40526261
90Episodic fever (HP:0001954)2.38711514
91Stomach cancer (HP:0012126)2.28532835
92Anorexia (HP:0002039)2.27499809
93Microcytic anemia (HP:0001935)2.25527942
94Increased IgM level (HP:0003496)2.23923778
95Entropion (HP:0000621)2.18943696
96Gangrene (HP:0100758)2.15707368
97Abnormality of the heme biosynthetic pathway (HP:0010472)2.15227768
98Acute hepatic failure (HP:0006554)2.15156146
99Interstitial pulmonary disease (HP:0006530)2.13142066
100Acute lymphatic leukemia (HP:0006721)2.12995068
101Pulmonary infiltrates (HP:0002113)2.12628895
102Neutropenia (HP:0001875)2.11768800
103Keratoconjunctivitis sicca (HP:0001097)2.10727780
104Emphysema (HP:0002097)2.10027170
105Abnormality of the prostate (HP:0008775)2.08752480
106Recurrent gram-negative bacterial infections (HP:0005420)2.08548081
107Macrocytic anemia (HP:0001972)2.07633847
108Hemoptysis (HP:0002105)2.06346637
109Sepsis (HP:0100806)2.06167528
110Spontaneous hematomas (HP:0007420)2.05977371
111Amaurosis fugax (HP:0100576)2.04931379
112Basal cell carcinoma (HP:0002671)2.03723238
113Increased serum ferritin (HP:0003281)2.03575177
114Abnormality of iron homeostasis (HP:0011031)2.03179909
115Recurrent pneumonia (HP:0006532)2.02512054
116Recurrent lower respiratory tract infections (HP:0002783)2.01587851
117Arterial thrombosis (HP:0004420)2.01167420
118Myelodysplasia (HP:0002863)1.99507164
119Skin rash (HP:0000988)1.99042112
120Skin ulcer (HP:0200042)1.98684594
121Alveolar cell carcinoma (HP:0006519)1.97905922
12211 pairs of ribs (HP:0000878)1.97319736
123Albinism (HP:0001022)1.97047550
124Restrictive lung disease (HP:0002091)1.95762349
125Glomerulopathy (HP:0100820)1.92991243
126Hepatosplenomegaly (HP:0001433)1.90918266
127Aplasia/Hypoplasia of the thymus (HP:0010515)1.89917336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.06714264
2KIT2.96165634
3TYK22.85184531
4TXK2.80765799
5IKBKE2.71142766
6JAK32.60920915
7EEF2K2.38964185
8TEC2.35529940
9IRAK42.34675669
10BTK2.31978581
11TBK12.22500620
12NME22.19125450
13CSF1R2.15441664
14ZAP702.07246471
15PRPF4B1.93446571
16FLT31.92612100
17SYK1.89042197
18BLK1.80041951
19GRK61.74453397
20STK161.74428214
21MAP3K141.71848879
22FGFR41.68125397
23JAK11.65356469
24STK101.59351297
25IKBKB1.52781757
26ITK1.50296813
27LRRK21.48409894
28EIF2AK11.44631055
29KDR1.42341665
30BMPR21.40336184
31WEE11.40072443
32ACVR1B1.40053552
33MAP3K111.34926159
34TGFBR11.31613220
35PIM21.31401010
36LCK1.29367192
37TESK21.28540607
38PIM11.20676312
39RPS6KA41.19993341
40RPS6KB21.17277954
41CDC71.14468687
42LYN1.14119322
43HCK1.11935312
44MAP3K131.08367400
45TAOK11.08229091
46FES1.05003050
47FGFR31.04686386
48NEK21.03846922
49CSK1.01655837
50IRAK10.98939393
51MAP3K100.97593331
52MARK30.96788530
53MAP3K120.95426607
54EPHB10.94913260
55EIF2AK30.93798966
56TNK20.92284366
57IRAK30.90293163
58CLK10.89339490
59VRK10.88036431
60TAOK30.85828728
61CDK190.85159661
62MAP2K30.83941504
63MAP3K10.82204268
64FGR0.82060155
65DYRK30.80322076
66SCYL20.79464961
67PIK3CG0.78835326
68MAP3K30.78828749
69MAPK110.78442113
70PRKD20.78408656
71SMG10.78044611
72TGFBR20.77497048
73ATR0.76405962
74RIPK40.75471187
75SRPK10.74770647
76MST40.72992062
77PDK10.71790233
78CHUK0.71398750
79MATK0.70555533
80MAPKAPK30.70467529
81RAF10.70240956
82STK40.69878221
83BUB10.67796929
84MARK20.67709549
85BRSK20.67395196
86CDK40.65317185
87ERN10.65214583
88TSSK60.64646693
89PKN20.63281847
90SIK20.62921456
91TRPM70.61479545
92BCKDK0.61335757
93IRAK20.60224015
94CDK70.59120196
95MAP2K20.58973830
96NLK0.58763194
97ADRBK20.57679605
98JAK20.56831226
99MAP3K70.53539890
100PASK0.51685020
101MAPK120.51023501
102CCNB10.49495995
103PRKCQ0.48270894
104YES10.47420711
105NUAK10.47353056
106FYN0.46141348
107MAP2K60.45040900
108SIK30.44360833
109MAP3K80.43701966
110MAPK70.43412272
111TLK10.43048539
112PDPK10.42946891
113TAOK20.41644268
114HIPK20.40839102
115PTK60.40279694
116RPS6KL10.39066058
117RPS6KC10.39066058
118RPS6KA60.38450656
119MUSK0.38213812
120ABL10.38085641
121PRKCD0.37757129
122PRKG20.37335325
123MAP3K50.36827787
124EIF2AK20.36343438
125GRK10.35880212
126TRIB30.35785911
127RPS6KA50.35776902
128DAPK10.35408799
129MAPKAPK20.35292581
130STK110.34902795
131ILK0.34245334
132VRK20.34183277
133AURKB0.33686964
134MAP3K60.33353792
135ALK0.33306279
136DAPK20.33091004
137DYRK1B0.32505767
138CDK120.30575881
139MAPK40.30253232
140MAPK30.30061363
141PTK2B0.29794544
142GRK70.29752314
143CDK60.29219117
144KSR20.24065746
145PRKCH0.22321907

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.35637716
2Ribosome_Homo sapiens_hsa030103.38149613
3DNA replication_Homo sapiens_hsa030303.28823629
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.52288554
5Mismatch repair_Homo sapiens_hsa034302.48139411
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.39196065
7Measles_Homo sapiens_hsa051622.37835667
8Antigen processing and presentation_Homo sapiens_hsa046122.34284231
9B cell receptor signaling pathway_Homo sapiens_hsa046622.33923968
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.28514894
11Base excision repair_Homo sapiens_hsa034102.15050603
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12136109
13Leishmaniasis_Homo sapiens_hsa051402.11645513
14Hematopoietic cell lineage_Homo sapiens_hsa046402.05746835
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.05409430
16Herpes simplex infection_Homo sapiens_hsa051681.99492456
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89260743
18Allograft rejection_Homo sapiens_hsa053301.82283296
19T cell receptor signaling pathway_Homo sapiens_hsa046601.71035013
20Non-homologous end-joining_Homo sapiens_hsa034501.70720872
21Homologous recombination_Homo sapiens_hsa034401.68277898
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.61071644
23Spliceosome_Homo sapiens_hsa030401.60132146
24RNA polymerase_Homo sapiens_hsa030201.59648780
25Osteoclast differentiation_Homo sapiens_hsa043801.56066249
26Proteasome_Homo sapiens_hsa030501.51167083
27Pyrimidine metabolism_Homo sapiens_hsa002401.48587957
28Nucleotide excision repair_Homo sapiens_hsa034201.48512906
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38546651
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36237025
31Graft-versus-host disease_Homo sapiens_hsa053321.35829838
32Influenza A_Homo sapiens_hsa051641.30419282
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29689070
34Legionellosis_Homo sapiens_hsa051341.25614624
35Rheumatoid arthritis_Homo sapiens_hsa053231.16782862
36Epstein-Barr virus infection_Homo sapiens_hsa051691.15674660
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14999964
38Hepatitis B_Homo sapiens_hsa051611.12893781
39Acute myeloid leukemia_Homo sapiens_hsa052211.10803233
40Fanconi anemia pathway_Homo sapiens_hsa034601.09443471
41Toxoplasmosis_Homo sapiens_hsa051451.09415357
42Apoptosis_Homo sapiens_hsa042101.08500249
43RNA degradation_Homo sapiens_hsa030181.07817150
44Shigellosis_Homo sapiens_hsa051311.07212007
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05931658
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02966850
47Cell cycle_Homo sapiens_hsa041101.01575739
48Chemokine signaling pathway_Homo sapiens_hsa040621.00351426
49p53 signaling pathway_Homo sapiens_hsa041150.99503200
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99219212
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94215516
52RNA transport_Homo sapiens_hsa030130.93879452
53Phagosome_Homo sapiens_hsa041450.92658795
54Viral myocarditis_Homo sapiens_hsa054160.91959158
55Caffeine metabolism_Homo sapiens_hsa002320.90886215
56Autoimmune thyroid disease_Homo sapiens_hsa053200.90070529
57Viral carcinogenesis_Homo sapiens_hsa052030.89700235
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.89461468
59TNF signaling pathway_Homo sapiens_hsa046680.89442107
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86953408
61Tuberculosis_Homo sapiens_hsa051520.84263295
62Pertussis_Homo sapiens_hsa051330.83910142
63Platelet activation_Homo sapiens_hsa046110.82924177
64Malaria_Homo sapiens_hsa051440.80206912
65Pentose phosphate pathway_Homo sapiens_hsa000300.79889366
66Asthma_Homo sapiens_hsa053100.78943984
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77561769
68HTLV-I infection_Homo sapiens_hsa051660.75859678
69Folate biosynthesis_Homo sapiens_hsa007900.72343378
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71388854
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71110386
72Hepatitis C_Homo sapiens_hsa051600.70988703
73Sulfur relay system_Homo sapiens_hsa041220.69519593
74Purine metabolism_Homo sapiens_hsa002300.68433118
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65293807
76Basal transcription factors_Homo sapiens_hsa030220.63236273
77One carbon pool by folate_Homo sapiens_hsa006700.60555392
78Pancreatic cancer_Homo sapiens_hsa052120.60382229
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59560074
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57803342
81Regulation of autophagy_Homo sapiens_hsa041400.56439760
82Type I diabetes mellitus_Homo sapiens_hsa049400.53754641
83Chronic myeloid leukemia_Homo sapiens_hsa052200.53144333
84Protein export_Homo sapiens_hsa030600.52297900
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50250046
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.50197131
87Salmonella infection_Homo sapiens_hsa051320.49708891
88Prolactin signaling pathway_Homo sapiens_hsa049170.49374550
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48814898
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48747635
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.45383733
92Staphylococcus aureus infection_Homo sapiens_hsa051500.45162094
93Systemic lupus erythematosus_Homo sapiens_hsa053220.44848734
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.44827197
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44485035
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42959486
97Small cell lung cancer_Homo sapiens_hsa052220.41651062
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41335160
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40824716
100African trypanosomiasis_Homo sapiens_hsa051430.40000816
101VEGF signaling pathway_Homo sapiens_hsa043700.39206639
102Choline metabolism in cancer_Homo sapiens_hsa052310.37486583
103N-Glycan biosynthesis_Homo sapiens_hsa005100.36301682
104Arachidonic acid metabolism_Homo sapiens_hsa005900.35587488
105Other glycan degradation_Homo sapiens_hsa005110.35262881
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.35045065
107Dorso-ventral axis formation_Homo sapiens_hsa043200.34782738
108Colorectal cancer_Homo sapiens_hsa052100.34178387
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34053696
110Non-small cell lung cancer_Homo sapiens_hsa052230.34040304
111Endocytosis_Homo sapiens_hsa041440.33726332
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33463450
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31599525
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29934608
115Inositol phosphate metabolism_Homo sapiens_hsa005620.29884424
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.29025614
117mRNA surveillance pathway_Homo sapiens_hsa030150.28553583
118Insulin resistance_Homo sapiens_hsa049310.28269948
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.27808787
120FoxO signaling pathway_Homo sapiens_hsa040680.27486778
121Lysosome_Homo sapiens_hsa041420.27406642
122MAPK signaling pathway_Homo sapiens_hsa040100.26003709
123Notch signaling pathway_Homo sapiens_hsa043300.25921943
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22355553
125mTOR signaling pathway_Homo sapiens_hsa041500.20814315
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20626255
127GnRH signaling pathway_Homo sapiens_hsa049120.18977846
128Linoleic acid metabolism_Homo sapiens_hsa005910.18365973
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16147218
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.15058530
131Renal cell carcinoma_Homo sapiens_hsa052110.14784799
132HIF-1 signaling pathway_Homo sapiens_hsa040660.09901866
133Ether lipid metabolism_Homo sapiens_hsa005650.09597513

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