HSP90AA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)4.62078027
2negative regulation of inclusion body assembly (GO:0090084)4.25813433
3DNA replication initiation (GO:0006270)4.17137155
4nucleobase biosynthetic process (GO:0046112)4.14945449
5nuclear pore organization (GO:0006999)4.10467615
6purine nucleobase biosynthetic process (GO:0009113)4.01138209
7mitotic metaphase plate congression (GO:0007080)4.00741435
8DNA unwinding involved in DNA replication (GO:0006268)3.99608943
9DNA replication-dependent nucleosome assembly (GO:0006335)3.88270597
10DNA replication-dependent nucleosome organization (GO:0034723)3.88270597
11* protein refolding (GO:0042026)3.84033104
12maturation of SSU-rRNA (GO:0030490)3.80939473
13formation of translation preinitiation complex (GO:0001731)3.78751909
14establishment of integrated proviral latency (GO:0075713)3.75988050
15nuclear pore complex assembly (GO:0051292)3.74575000
16regulation of helicase activity (GO:0051095)3.66256167
17neuronal stem cell maintenance (GO:0097150)3.62919655
18mitotic sister chromatid cohesion (GO:0007064)3.60742011
19DNA strand elongation involved in DNA replication (GO:0006271)3.60000757
20regulation of centriole replication (GO:0046599)3.59557555
21DNA replication checkpoint (GO:0000076)3.57594461
22ribosome biogenesis (GO:0042254)3.57399556
23regulation of centrosome cycle (GO:0046605)3.56989275
24sister chromatid segregation (GO:0000819)3.55339696
25chromatin remodeling at centromere (GO:0031055)3.52571184
26protein localization to kinetochore (GO:0034501)3.52135822
27mitotic chromosome condensation (GO:0007076)3.50835952
28metaphase plate congression (GO:0051310)3.50159890
29mitotic nuclear envelope disassembly (GO:0007077)3.46067846
30CENP-A containing nucleosome assembly (GO:0034080)3.41533246
31DNA strand elongation (GO:0022616)3.38228270
32* establishment of protein localization to mitochondrial membrane (GO:0090151)3.37724803
33neuron fate determination (GO:0048664)3.35661090
34axon ensheathment in central nervous system (GO:0032291)3.34114977
35central nervous system myelination (GO:0022010)3.34114977
36histone exchange (GO:0043486)3.32824944
37regulation of posttranscriptional gene silencing (GO:0060147)3.31890988
38regulation of gene silencing by miRNA (GO:0060964)3.31890988
39regulation of gene silencing by RNA (GO:0060966)3.31890988
40regulation of DNA endoreduplication (GO:0032875)3.31475906
41regulation of translational termination (GO:0006449)3.29463042
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.29078883
43regulation of histone H3-K9 methylation (GO:0051570)3.28431160
44proteasome assembly (GO:0043248)3.27039401
45spliceosomal snRNP assembly (GO:0000387)3.26885840
46positive regulation of chromosome segregation (GO:0051984)3.26119510
47membrane disassembly (GO:0030397)3.26085529
48nuclear envelope disassembly (GO:0051081)3.26085529
49somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23741443
50somatic hypermutation of immunoglobulin genes (GO:0016446)3.23741443
51ribonucleoprotein complex biogenesis (GO:0022613)3.23277949
52DNA replication-independent nucleosome organization (GO:0034724)3.20862702
53DNA replication-independent nucleosome assembly (GO:0006336)3.20862702
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20540442
55synapsis (GO:0007129)3.19747744
56IMP biosynthetic process (GO:0006188)3.19605945
57microtubule depolymerization (GO:0007019)3.17722795
58negative regulation of oligodendrocyte differentiation (GO:0048715)3.15773715
59notochord development (GO:0030903)3.15635284
60negative regulation of histone methylation (GO:0031061)3.14296730
61mitotic sister chromatid segregation (GO:0000070)3.14000610
62ribosomal large subunit biogenesis (GO:0042273)3.13889773
63UTP biosynthetic process (GO:0006228)3.13383176
64rRNA processing (GO:0006364)3.13155152
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11030327
66establishment of chromosome localization (GO:0051303)3.09331732
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08184088
68folic acid-containing compound biosynthetic process (GO:0009396)3.07382672
69kinetochore organization (GO:0051383)3.07348239
70telomere maintenance via semi-conservative replication (GO:0032201)3.06838709
71histone arginine methylation (GO:0034969)3.06288985
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06270990
73transcription elongation from RNA polymerase I promoter (GO:0006362)3.06019027
74rRNA metabolic process (GO:0016072)3.05456795
75protein complex localization (GO:0031503)3.05118666
76regulation of spindle organization (GO:0090224)3.02814856
77protein localization to chromosome, centromeric region (GO:0071459)3.00288388
78spindle checkpoint (GO:0031577)2.98832715
79heart valve formation (GO:0003188)2.98708016
80centriole replication (GO:0007099)2.96999550
81regulation of chromosome segregation (GO:0051983)2.95909517
82attachment of spindle microtubules to kinetochore (GO:0008608)2.95721484
837-methylguanosine mRNA capping (GO:0006370)2.95483731
84mitotic spindle checkpoint (GO:0071174)2.93795470
85negative regulation of chromosome segregation (GO:0051985)2.93369373
86transcription elongation from RNA polymerase III promoter (GO:0006385)2.92045275
87termination of RNA polymerase III transcription (GO:0006386)2.92045275
88negative regulation of mitotic sister chromatid separation (GO:2000816)2.91696387
89negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91696387
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91696387
91negative regulation of sister chromatid segregation (GO:0033046)2.91696387
927-methylguanosine RNA capping (GO:0009452)2.91359691
93RNA capping (GO:0036260)2.91359691
94resolution of meiotic recombination intermediates (GO:0000712)2.90924892
95termination of RNA polymerase I transcription (GO:0006363)2.90855567
96DNA topological change (GO:0006265)2.90655995
97rRNA modification (GO:0000154)2.90039288
98regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89995589
99GTP biosynthetic process (GO:0006183)2.88293562
100meiotic chromosome segregation (GO:0045132)2.87796169
101pore complex assembly (GO:0046931)2.87539409
102* chaperone-mediated protein complex assembly (GO:0051131)2.87466542
103peptidyl-arginine omega-N-methylation (GO:0035247)2.87385712
104transcription-coupled nucleotide-excision repair (GO:0006283)2.86905307
105regulation of centrosome duplication (GO:0010824)2.86196030
106blastocyst development (GO:0001824)2.85736363
107IMP metabolic process (GO:0046040)2.84939590
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84381934
109hindbrain development (GO:0030902)2.84245766
110otic vesicle formation (GO:0030916)2.83673623
111spliceosomal complex assembly (GO:0000245)2.83607960
112mitotic spindle assembly checkpoint (GO:0007094)2.83566047
113regulation of mitotic metaphase/anaphase transition (GO:0030071)2.83497016
114spindle assembly checkpoint (GO:0071173)2.82556657
115protein K6-linked ubiquitination (GO:0085020)2.82379605
116negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81922327
117negative regulation of ligase activity (GO:0051352)2.81922327
118regulation of inclusion body assembly (GO:0090083)2.80872280
119mitotic recombination (GO:0006312)2.80832268
120telomere maintenance via recombination (GO:0000722)2.80831215
121positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80678594
122guanosine-containing compound biosynthetic process (GO:1901070)2.80520163
123dopaminergic neuron differentiation (GO:0071542)2.77143610
124cochlea development (GO:0090102)2.72928095
125midbrain development (GO:0030901)2.68269300
126axonemal dynein complex assembly (GO:0070286)2.67556650
127sister chromatid cohesion (GO:0007062)2.64652230
128heterochromatin organization (GO:0070828)2.64566510
129forebrain neuron differentiation (GO:0021879)2.62977771
130mitotic spindle organization (GO:0007052)2.62842661
131negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.58055084
132pattern specification involved in kidney development (GO:0061004)2.54721162
133regulation of mitotic spindle organization (GO:0060236)2.52626372
134DNA ligation (GO:0006266)2.52232396
135regulation of mesenchymal cell apoptotic process (GO:2001053)2.51497567
136negative regulation of astrocyte differentiation (GO:0048712)2.50546285
137epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.50466444
138limb bud formation (GO:0060174)2.49780645
139regulation of timing of cell differentiation (GO:0048505)2.47880335
140primitive streak formation (GO:0090009)2.47852491
141radial glial cell differentiation (GO:0060019)2.47165196
142negative regulation of glial cell differentiation (GO:0045686)2.46927599
143negative regulation of DNA-dependent DNA replication (GO:2000104)2.46751037
144chaperone mediated protein folding requiring cofactor (GO:0051085)2.46294009
145presynaptic membrane assembly (GO:0097105)2.46029726
146regulation of development, heterochronic (GO:0040034)2.41102871
147nephron tubule morphogenesis (GO:0072078)2.39063056
148nephron epithelium morphogenesis (GO:0072088)2.39063056
149regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.35133061
150chromosome organization involved in meiosis (GO:0070192)2.34791186
151microtubule polymerization or depolymerization (GO:0031109)2.33454317
152intra-S DNA damage checkpoint (GO:0031573)2.31237901
153behavioral response to nicotine (GO:0035095)2.29867540
154translesion synthesis (GO:0019985)2.29061919
155chromosome condensation (GO:0030261)2.28400733
156protein localization to chromosome (GO:0034502)2.28366395
157neural crest cell development (GO:0014032)2.28003618
158epithelial tube branching involved in lung morphogenesis (GO:0060441)2.27636151
159centriole assembly (GO:0098534)2.27135151
160DNA damage response, detection of DNA damage (GO:0042769)2.26636304
161histone H2A acetylation (GO:0043968)2.26354250
162somite development (GO:0061053)2.25982665
163neuroblast proliferation (GO:0007405)2.25701063
164replication fork processing (GO:0031297)2.25662545
165spermatid nucleus differentiation (GO:0007289)2.22883704
166ATP-dependent chromatin remodeling (GO:0043044)2.21072422
167maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.19991719
168chromosome segregation (GO:0007059)2.18008819
169DNA synthesis involved in DNA repair (GO:0000731)2.17645862
170ventricular trabecula myocardium morphogenesis (GO:0003222)2.17639337
171DNA packaging (GO:0006323)2.16650704

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.94278811
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.41168865
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.69031840
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.55199836
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.37666208
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27445598
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07996775
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.03601399
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96665878
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.94960534
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.85988970
12* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.79608990
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.76421592
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72394621
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70081867
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63125217
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57504040
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57011385
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54238825
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46051554
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.42478981
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33611906
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.27587333
24XRN2_22483619_ChIP-Seq_HELA_Human2.20451049
25AR_21909140_ChIP-Seq_LNCAP_Human2.16821599
26* POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.16679676
27VDR_23849224_ChIP-Seq_CD4+_Human2.13453352
28* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.10843816
29NANOG_18555785_ChIP-Seq_MESCs_Mouse2.10222448
30* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08753949
31* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.06445193
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.05290529
33EZH2_22144423_ChIP-Seq_EOC_Human2.04784335
34RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00870678
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.98461448
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92145171
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92056301
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.91232853
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.91232853
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.91232853
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89941072
42TTF2_22483619_ChIP-Seq_HELA_Human1.86531857
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86472897
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82830021
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82619852
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82106698
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81611219
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79469457
49* EWS_26573619_Chip-Seq_HEK293_Human1.79026544
50DCP1A_22483619_ChIP-Seq_HELA_Human1.78185606
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.77602872
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73755666
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69838194
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.66571608
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.65725418
56FOXP3_21729870_ChIP-Seq_TREG_Human1.63999801
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.62424916
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62004941
59* GABP_19822575_ChIP-Seq_HepG2_Human1.60808945
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.59679874
61ELK1_19687146_ChIP-ChIP_HELA_Human1.58852622
62ZNF274_21170338_ChIP-Seq_K562_Hela1.58720100
63RNF2_27304074_Chip-Seq_NSC_Mouse1.53776776
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.51785668
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50086266
66* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48679335
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46152409
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45375160
69VDR_22108803_ChIP-Seq_LS180_Human1.42671453
70* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.40695414
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39385831
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38736026
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37651032
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37347326
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.34333083
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34056224
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33436546
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32882770
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32801848
80* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31546207
81GBX2_23144817_ChIP-Seq_PC3_Human1.25144001
82* KDM5A_27292631_Chip-Seq_BREAST_Human1.25079170
83TAF15_26573619_Chip-Seq_HEK293_Human1.23025972
84* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21449789
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21346790
86* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19888901
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19709716
88AR_21572438_ChIP-Seq_LNCaP_Human1.19213851
89SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18951109
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16741404
91SOX9_26525672_Chip-Seq_HEART_Mouse1.16143054
92* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15297420
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15031537
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13386416
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13146540
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12414362
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12175977
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10817584
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09908987
100CIITA_25753668_ChIP-Seq_RAJI_Human1.09848576
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07899158
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07332705
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05933498
104SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05807778
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05686060
106RING1B_27294783_Chip-Seq_NPCs_Mouse1.04560174
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.03528884
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03525697
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03476437
110ZNF263_19887448_ChIP-Seq_K562_Human1.03475622
111* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02356761
112* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00703301
113JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00619080
114MYC_18940864_ChIP-ChIP_HL60_Human0.99934976
115SOX2_16153702_ChIP-ChIP_HESCs_Human0.99439280
116P300_19829295_ChIP-Seq_ESCs_Human0.99361088
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99314904
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.99230907
119NANOG_16153702_ChIP-ChIP_HESCs_Human0.98937178
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98070638
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97769809
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97769809
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97319897
124* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97103658
125* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97084346
126FUS_26573619_Chip-Seq_HEK293_Human0.95858717
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95715466
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.95441340
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94485747
130* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94164226
131* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93783648
132SRF_21415370_ChIP-Seq_HL-1_Mouse0.93682731
133EGR1_19374776_ChIP-ChIP_THP-1_Human0.93399780
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93206531
135RNF2_27304074_Chip-Seq_ESCs_Mouse0.92437305
136* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91690330
137* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91291973
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91067989
139CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91003074
140* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90077156
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.89567393
142GATA1_26923725_Chip-Seq_HPCs_Mouse0.89398584
143* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88168647
144KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87475232
145TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87384924
146WT1_19549856_ChIP-ChIP_CCG9911_Human0.87362833
147REST_21632747_ChIP-Seq_MESCs_Mouse0.86957761
148POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86640765
149SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86100691
150* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85065303
151POU5F1_16518401_ChIP-PET_MESCs_Mouse0.83654335

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.75411097
2MP0004957_abnormal_blastocyst_morpholog4.18251434
3MP0010094_abnormal_chromosome_stability4.05350110
4MP0008057_abnormal_DNA_replication4.04044510
5MP0003111_abnormal_nucleus_morphology4.02768370
6MP0003077_abnormal_cell_cycle3.37701131
7MP0008877_abnormal_DNA_methylation3.20272234
8MP0008058_abnormal_DNA_repair3.07999211
9MP0003123_paternal_imprinting3.06275366
10MP0008932_abnormal_embryonic_tissue2.77002635
11MP0001730_embryonic_growth_arrest2.41439368
12MP0000566_synostosis2.26703660
13MP0003718_maternal_effect2.11507757
14MP0000350_abnormal_cell_proliferation1.98770362
15MP0002653_abnormal_ependyma_morphology1.98137195
16MP0004133_heterotaxia1.92099829
17MP0003880_abnormal_central_pattern1.86195049
18MP0008007_abnormal_cellular_replicative1.80568631
19MP0000569_abnormal_digit_pigmentation1.79813978
20MP0003786_premature_aging1.79614116
21MP0003136_yellow_coat_color1.78913459
22MP0002938_white_spotting1.73999216
23MP0003121_genomic_imprinting1.71947183
24MP0002084_abnormal_developmental_patter1.67195822
25MP0001697_abnormal_embryo_size1.64912262
26MP0002210_abnormal_sex_determination1.64201259
27MP0002085_abnormal_embryonic_tissue1.61770746
28MP0001529_abnormal_vocalization1.61487793
29MP0001672_abnormal_embryogenesis/_devel1.57008458
30MP0005380_embryogenesis_phenotype1.57008458
31MP0001929_abnormal_gametogenesis1.56062588
32MP0009379_abnormal_foot_pigmentation1.53161249
33MP0003890_abnormal_embryonic-extraembry1.50717352
34MP0000537_abnormal_urethra_morphology1.48970029
35MP0001145_abnormal_male_reproductive1.48065731
36MP0003315_abnormal_perineum_morphology1.46660808
37MP0005423_abnormal_somatic_nervous1.46012222
38MP0002160_abnormal_reproductive_system1.45838477
39MP0002697_abnormal_eye_size1.44210643
40MP0002080_prenatal_lethality1.43630501
41MP0010352_gastrointestinal_tract_polyps1.42678127
42MP0003806_abnormal_nucleotide_metabolis1.40278662
43MP0003698_abnormal_male_reproductive1.36620065
44MP0010307_abnormal_tumor_latency1.36281478
45MP0004742_abnormal_vestibular_system1.35312541
46MP0003119_abnormal_digestive_system1.34211845
47MP0005410_abnormal_fertilization1.33439888
48MP0000631_abnormal_neuroendocrine_gland1.30492598
49MP0005171_absent_coat_pigmentation1.29482696
50MP0003984_embryonic_growth_retardation1.27850688
51MP0001346_abnormal_lacrimal_gland1.27197717
52MP0001440_abnormal_grooming_behavior1.26052961
53MP0002088_abnormal_embryonic_growth/wei1.25153629
54MP0002928_abnormal_bile_duct1.24631512
55MP0000653_abnormal_sex_gland1.24570220
56MP0002277_abnormal_respiratory_mucosa1.24040714
57MP0006072_abnormal_retinal_apoptosis1.21824265
58MP0000647_abnormal_sebaceous_gland1.21748843
59MP0002282_abnormal_trachea_morphology1.21577462
60MP0001293_anophthalmia1.20786732
61MP0004197_abnormal_fetal_growth/weight/1.19762575
62MP0006292_abnormal_olfactory_placode1.19456066
63MP0003861_abnormal_nervous_system1.17477823
64MP0009053_abnormal_anal_canal1.17309169
65MP0002086_abnormal_extraembryonic_tissu1.16834804
66MP0003567_abnormal_fetal_cardiomyocyte1.14101391
67MP0000955_abnormal_spinal_cord1.13074956
68MP0003937_abnormal_limbs/digits/tail_de1.10017922
69MP0005389_reproductive_system_phenotype1.09210728
70MP0001299_abnormal_eye_distance/1.09048939
71MP0003755_abnormal_palate_morphology1.08229501
72MP0005084_abnormal_gallbladder_morpholo1.07275754
73MP0000762_abnormal_tongue_morphology1.06323315
74MP0002249_abnormal_larynx_morphology1.06027569
75MP0000049_abnormal_middle_ear1.05021478
76MP0002638_abnormal_pupillary_reflex1.03474213
77MP0003943_abnormal_hepatobiliary_system1.01469153
78MP0009697_abnormal_copulation1.01140707
79MP0010030_abnormal_orbit_morphology1.01008540
80MP0002092_abnormal_eye_morphology1.00038824
81MP0001485_abnormal_pinna_reflex0.98255215
82MP0005623_abnormal_meninges_morphology0.98228655
83MP0000313_abnormal_cell_death0.97300652
84MP0009046_muscle_twitch0.97082108
85MP0001486_abnormal_startle_reflex0.96793312
86MP0000026_abnormal_inner_ear0.96112746
87MP0002161_abnormal_fertility/fecundity0.96000814
88MP0000534_abnormal_ureter_morphology0.95885664
89MP0002233_abnormal_nose_morphology0.95467733
90MP0004270_analgesia0.94646161
91MP0000358_abnormal_cell_content/0.94494819
92MP0000383_abnormal_hair_follicle0.94402244
93MP0002067_abnormal_sensory_capabilities0.93514358
94MP0002736_abnormal_nociception_after0.92425523
95MP0006035_abnormal_mitochondrial_morpho0.91415884
96MP0000778_abnormal_nervous_system0.91196532
97MP0004859_abnormal_synaptic_plasticity0.90733803
98MP0003935_abnormal_craniofacial_develop0.90194458
99MP0001727_abnormal_embryo_implantation0.89704744
100MP0000428_abnormal_craniofacial_morphol0.88915592
101MP0005391_vision/eye_phenotype0.87983676
102MP0003635_abnormal_synaptic_transmissio0.86865619
103MP0002735_abnormal_chemical_nociception0.85514550
104MP0000579_abnormal_nail_morphology0.84703720
105MP0003950_abnormal_plasma_membrane0.84530701
106MP0002152_abnormal_brain_morphology0.83979438
107MP0005174_abnormal_tail_pigmentation0.83523583
108MP0002081_perinatal_lethality0.83171461
109MP0003283_abnormal_digestive_organ0.82681199
110MP0001188_hyperpigmentation0.82253687
111MP0001177_atelectasis0.82012455
112MP0009703_decreased_birth_body0.78629874
113MP0006276_abnormal_autonomic_nervous0.78042594
114MP0001905_abnormal_dopamine_level0.78003522
115MP0002102_abnormal_ear_morphology0.77773533
116MP0002734_abnormal_mechanical_nocicepti0.76268289
117MP0003941_abnormal_skin_development0.75739466
118MP0002272_abnormal_nervous_system0.75161502
119MP0005384_cellular_phenotype0.73994061
120MP0009745_abnormal_behavioral_response0.73605637
121MP0003632_abnormal_nervous_system0.72968590
122MP0001286_abnormal_eye_development0.72620205
123MP0003938_abnormal_ear_development0.71347081
124MP0009672_abnormal_birth_weight0.71185863
125MP0002063_abnormal_learning/memory/cond0.70528168
126MP0002064_seizures0.70295233
127MP0005386_behavior/neurological_phenoty0.68111460
128MP0004924_abnormal_behavior0.68111460
129MP0003787_abnormal_imprinting0.67796158
130MP0002111_abnormal_tail_morphology0.66430703
131MP0001919_abnormal_reproductive_system0.65824895
132MP0005266_abnormal_metabolism0.65724597
133MP0002572_abnormal_emotion/affect_behav0.65638535
134MP0004142_abnormal_muscle_tone0.65601123
135MP0002751_abnormal_autonomic_nervous0.65436088
136MP0005187_abnormal_penis_morphology0.65396643
137MP0003936_abnormal_reproductive_system0.64923434
138MP0001968_abnormal_touch/_nociception0.64680687
139MP0002184_abnormal_innervation0.63936785
140MP0005377_hearing/vestibular/ear_phenot0.63237388
141MP0003878_abnormal_ear_physiology0.63237388
142MP0004885_abnormal_endolymph0.62521788

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.46591505
2Abnormality of the labia minora (HP:0012880)4.33499937
3Breast hypoplasia (HP:0003187)3.93841552
4Cerebral hypomyelination (HP:0006808)3.71930699
5Ependymoma (HP:0002888)3.69577854
6Supernumerary spleens (HP:0009799)3.66972101
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.56384787
8Carpal bone hypoplasia (HP:0001498)3.29707471
9Absent radius (HP:0003974)3.25351890
10Septo-optic dysplasia (HP:0100842)3.22121684
11Absent forearm bone (HP:0003953)3.11753513
12Aplasia involving forearm bones (HP:0009822)3.11753513
13Abnormal respiratory motile cilium physiology (HP:0012261)2.97407648
14Agnosia (HP:0010524)2.94976110
15Medulloblastoma (HP:0002885)2.93078853
16Volvulus (HP:0002580)2.88592278
17Impulsivity (HP:0100710)2.83818575
18Colon cancer (HP:0003003)2.82717038
19Abnormal respiratory epithelium morphology (HP:0012253)2.76007759
20Abnormal respiratory motile cilium morphology (HP:0005938)2.76007759
21Rhinitis (HP:0012384)2.73358324
22Abnormal ciliary motility (HP:0012262)2.67373945
23Patellar aplasia (HP:0006443)2.66519075
24Selective tooth agenesis (HP:0001592)2.61400693
25True hermaphroditism (HP:0010459)2.60908928
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.58665465
27CNS hypomyelination (HP:0003429)2.58400830
28Degeneration of anterior horn cells (HP:0002398)2.53009145
29Abnormality of the anterior horn cell (HP:0006802)2.53009145
30Aplasia/Hypoplasia of the patella (HP:0006498)2.51893517
31Abnormality of the astrocytes (HP:0100707)2.49386782
32Astrocytoma (HP:0009592)2.49386782
33Increased nuchal translucency (HP:0010880)2.49298699
34Horseshoe kidney (HP:0000085)2.48568708
35Cortical dysplasia (HP:0002539)2.48408379
36Chronic bronchitis (HP:0004469)2.47529509
37Rough bone trabeculation (HP:0100670)2.46060428
38Chromsome breakage (HP:0040012)2.42472121
39Oral leukoplakia (HP:0002745)2.42128711
40Maternal diabetes (HP:0009800)2.39057884
41Rhabdomyosarcoma (HP:0002859)2.38687092
42Bilateral microphthalmos (HP:0007633)2.38462226
43Gastrointestinal atresia (HP:0002589)2.38123435
44Neoplasm of the oral cavity (HP:0100649)2.38004470
45Absent septum pellucidum (HP:0001331)2.35509940
46Glioma (HP:0009733)2.34495969
47Stenosis of the external auditory canal (HP:0000402)2.34262650
48Abnormality of abdominal situs (HP:0011620)2.33700770
49Abdominal situs inversus (HP:0003363)2.33700770
50Amyotrophic lateral sclerosis (HP:0007354)2.32591537
51Aplasia/hypoplasia of the humerus (HP:0006507)2.29663710
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.29333406
53Anophthalmia (HP:0000528)2.29268317
54Absent/shortened dynein arms (HP:0200106)2.28911136
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.28911136
56Abnormality of the diencephalon (HP:0010662)2.26561318
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.26105705
58Delusions (HP:0000746)2.24909271
59Abnormality of the carotid arteries (HP:0005344)2.24583383
60Shoulder girdle muscle weakness (HP:0003547)2.22361629
61Postnatal microcephaly (HP:0005484)2.19539991
62Abnormality of chromosome stability (HP:0003220)2.19476887
63Reticulocytopenia (HP:0001896)2.18955494
64Biliary tract neoplasm (HP:0100574)2.18274550
65Meckel diverticulum (HP:0002245)2.17046521
66Focal motor seizures (HP:0011153)2.16574703
67Abnormality of the preputium (HP:0100587)2.12446935
68Abnormality of cells of the erythroid lineage (HP:0012130)2.10354641
69Absent thumb (HP:0009777)2.09468533
70Congenital, generalized hypertrichosis (HP:0004540)2.08324784
71Abnormality of the septum pellucidum (HP:0007375)2.04672740
72Hemivertebrae (HP:0002937)2.02624925
73Facial cleft (HP:0002006)2.02139793
74Abnormality of the ileum (HP:0001549)2.01787216
75Molar tooth sign on MRI (HP:0002419)2.01246623
76Abnormality of midbrain morphology (HP:0002418)2.01246623
77Abnormal number of incisors (HP:0011064)2.00697117
78Neoplasm of the pancreas (HP:0002894)2.00419339
79Rib fusion (HP:0000902)1.99558648
80Esophageal atresia (HP:0002032)1.98859093
81Sclerocornea (HP:0000647)1.97766136
82Type II lissencephaly (HP:0007260)1.95261426
83Premature ovarian failure (HP:0008209)1.94672738
84Morphological abnormality of the inner ear (HP:0011390)1.94643191
85Concave nail (HP:0001598)1.92377538
86Oligodactyly (hands) (HP:0001180)1.92343397
87Macrocytic anemia (HP:0001972)1.91792821
88Aplasia/Hypoplasia of the sternum (HP:0006714)1.90284615
89Abnormality of the duodenum (HP:0002246)1.88840174
90Aplasia/Hypoplasia of the earlobes (HP:0009906)1.87543403
91Abnormality of the lower motor neuron (HP:0002366)1.86615419
92Secondary amenorrhea (HP:0000869)1.86524507
93Missing ribs (HP:0000921)1.86305878
94Pancreatic fibrosis (HP:0100732)1.85487023
95Nephronophthisis (HP:0000090)1.85204940
96Sloping forehead (HP:0000340)1.85083110
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.84924896
98Facial hemangioma (HP:0000329)1.84418060
99Fibular hypoplasia (HP:0003038)1.84382515
100Preaxial hand polydactyly (HP:0001177)1.83424379
101Asplenia (HP:0001746)1.83066542
102Optic nerve hypoplasia (HP:0000609)1.82694049
103Short humerus (HP:0005792)1.82078791
104Abnormality of the pons (HP:0007361)1.80607421
105Personality changes (HP:0000751)1.79991049
106Abnormal number of erythroid precursors (HP:0012131)1.79903861
107Abnormal sex determination (HP:0012244)1.79852116
108Sex reversal (HP:0012245)1.79852116
109Abnormal lung lobation (HP:0002101)1.78988190
110Pancreatic cysts (HP:0001737)1.77998152
11111 pairs of ribs (HP:0000878)1.77240305
112Unsteady gait (HP:0002317)1.76881720
113Hemiparesis (HP:0001269)1.76443569
114Oligodactyly (HP:0012165)1.76033892
115Cellular immunodeficiency (HP:0005374)1.74752546
116Small intestinal stenosis (HP:0012848)1.74378303
117Duodenal stenosis (HP:0100867)1.74378303
118Neoplasm of striated muscle (HP:0009728)1.73300542
119Breast aplasia (HP:0100783)1.72812107
120Abnormal trabecular bone morphology (HP:0100671)1.72677435
121Abnormality of chromosome segregation (HP:0002916)1.71631540
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70432325
123Pheochromocytoma (HP:0002666)1.69442092
124Basal cell carcinoma (HP:0002671)1.68931055
125Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.68929681
126Degeneration of the lateral corticospinal tracts (HP:0002314)1.68929681
127Glossoptosis (HP:0000162)1.68545679
128Premature graying of hair (HP:0002216)1.68428251
129Pelvic girdle muscle weakness (HP:0003749)1.67400843
130Cerebellar dysplasia (HP:0007033)1.67254256
131Median cleft lip (HP:0000161)1.67049880
132Hypoplasia of the pons (HP:0012110)1.66906818
133Aplasia/Hypoplasia of the spleen (HP:0010451)1.64331038
134Holoprosencephaly (HP:0001360)1.63992620
135Retinal dysplasia (HP:0007973)1.63149087
136Midline defect of the nose (HP:0004122)1.63102107
137Acute necrotizing encephalopathy (HP:0006965)1.61905344
138Increased hepatocellular lipid droplets (HP:0006565)1.61731947
139Aplasia/Hypoplasia of the fibula (HP:0006492)1.61425721
140Aplasia/Hypoplasia of the breasts (HP:0010311)1.61387039
141Triphalangeal thumb (HP:0001199)1.61367699
142Scrotal hypoplasia (HP:0000046)1.61163737
143Duplicated collecting system (HP:0000081)1.60851002
144Megaloblastic anemia (HP:0001889)1.60569833
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.58396774
146Supernumerary bones of the axial skeleton (HP:0009144)1.57005425
147Medial flaring of the eyebrow (HP:0010747)1.56850889
148Intellectual disability, profound (HP:0002187)1.56674504
149Supernumerary ribs (HP:0005815)1.56192812
150Gait imbalance (HP:0002141)1.53976738
151Lissencephaly (HP:0001339)1.53436079
152Ectopic kidney (HP:0000086)1.53350009
153Vertebral hypoplasia (HP:0008417)1.52551961
154Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.52551961
155Duplication of thumb phalanx (HP:0009942)1.51987195
156Abnormality of the corticospinal tract (HP:0002492)1.51783368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.37086906
2BUB14.61886941
3TSSK64.51011035
4CDC73.74299397
5* WEE13.21379057
6SRPK12.75282973
7EPHA22.71342857
8TTK2.59555437
9EIF2AK12.52855497
10* PNCK2.50012097
11NEK12.49017109
12PLK32.41668100
13PLK42.30348766
14STK162.09773332
15NEK21.98923723
16PLK11.96209064
17PDK31.90551375
18PDK41.90551375
19CASK1.90445116
20TNIK1.74068099
21TAF11.57392707
22VRK11.55773232
23EIF2AK31.50347054
24AURKA1.49752437
25MKNK11.49682220
26BRSK21.43303588
27NME11.40753719
28SCYL21.40085401
29PDK21.39357154
30CHEK21.38570015
31DYRK31.35121939
32RPS6KB21.34637724
33MKNK21.34564702
34TESK21.32466818
35CDK31.31275364
36AKT31.29846360
37PASK1.24442578
38ATR1.23528431
39MAPKAPK51.22860957
40AURKB1.22519143
41MARK11.22316914
42MAP3K91.21529547
43CHEK11.19422533
44CAMK1G1.19348928
45LATS21.15618027
46EPHB21.15488319
47ALK1.15356705
48WNK41.09892623
49ACVR1B1.07956411
50VRK21.07804966
51MAP3K81.07659964
52LATS11.07437787
53TLK11.06566771
54CDK71.05887175
55NTRK21.04254451
56BRAF1.03563637
57MAP3K40.99551183
58MAPK130.99379760
59ARAF0.99166987
60STK390.98899636
61PLK20.96940890
62TRIM280.95841193
63BRSK10.95264613
64CDK120.91213798
65* CSNK1E0.90106290
66PRKCI0.88551886
67CDK20.86673482
68BMPR1B0.84611579
69* CSNK2A20.84293737
70ERBB40.83833783
71CCNB10.83265535
72* ATM0.80785196
73BCR0.80314675
74ZAK0.78934473
75PBK0.77972190
76CAMK1D0.75794538
77CDK10.73078332
78CSNK1G30.71824159
79WNK30.71745584
80NTRK30.67945676
81MINK10.67243868
82UHMK10.66958379
83EPHA40.66619032
84PAK10.65801787
85BRD40.64927567
86PAK20.64888362
87DYRK20.63198972
88CDK40.62847477
89INSRR0.61624324
90* CSNK2A10.61599915
91PAK40.61355532
92PRKD30.59352514
93CDK140.58858513
94TYRO30.57627494
95STK30.57576051
96ERBB30.57517477
97KSR10.56858506
98STK38L0.55610392
99NME20.55607129
100MST40.55190517
101CSNK1D0.55103092
102MST1R0.53365769
103FGFR10.52226805
104CDK150.51591794
105YES10.51484488
106CDK180.50318030
107CDK11A0.50161644
108MELK0.49004343
109CDK190.48911516
110CSNK1G20.48010041
111RPS6KA50.47622318
112MAP3K100.46535417
113* PRKDC0.45825786
114NUAK10.44573641
115IRAK10.44383722
116CDK80.41574742
117CSNK1G10.41184841
118MAP2K20.38979500
119RAF10.37183135
120MAPK100.36905066
121* PRKCG0.35312880
122CAMK2B0.35305479
123GSK3B0.33503342
124MET0.32162598
125CSNK1A1L0.30926938
126DYRK1A0.30251185
127MAP3K120.30204082
128MAPK140.29493591
129DAPK10.28753687
130MAP2K70.28541681
131KSR20.27268705
132EIF2AK20.27209956
133TGFBR10.26139532
134FGR0.23921874
135LIMK10.22272105
136TESK10.21509970

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.19812497
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.15675635
3Mismatch repair_Homo sapiens_hsa034303.95879013
4DNA replication_Homo sapiens_hsa030303.91039372
5RNA polymerase_Homo sapiens_hsa030203.77291526
6RNA transport_Homo sapiens_hsa030133.53746786
7Spliceosome_Homo sapiens_hsa030403.37311787
8Ribosome_Homo sapiens_hsa030102.87135842
9Nucleotide excision repair_Homo sapiens_hsa034202.81740865
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.77520187
11Homologous recombination_Homo sapiens_hsa034402.57315156
12Cell cycle_Homo sapiens_hsa041102.41358674
13Pyrimidine metabolism_Homo sapiens_hsa002402.37528278
14Basal transcription factors_Homo sapiens_hsa030222.13800552
15One carbon pool by folate_Homo sapiens_hsa006702.13559416
16Fanconi anemia pathway_Homo sapiens_hsa034602.09614269
17Base excision repair_Homo sapiens_hsa034102.03174460
18RNA degradation_Homo sapiens_hsa030181.87800286
19Oocyte meiosis_Homo sapiens_hsa041141.87304229
20Non-homologous end-joining_Homo sapiens_hsa034501.86482090
21mRNA surveillance pathway_Homo sapiens_hsa030151.83770278
22Huntingtons disease_Homo sapiens_hsa050161.73372349
23Steroid biosynthesis_Homo sapiens_hsa001001.70529406
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.68293381
25Oxidative phosphorylation_Homo sapiens_hsa001901.60719222
26Purine metabolism_Homo sapiens_hsa002301.49647718
27Parkinsons disease_Homo sapiens_hsa050121.45657079
28Vitamin B6 metabolism_Homo sapiens_hsa007501.41293499
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32020751
30Cocaine addiction_Homo sapiens_hsa050301.24738370
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23109813
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.18902835
33Epstein-Barr virus infection_Homo sapiens_hsa051691.18516427
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14007964
35Nicotine addiction_Homo sapiens_hsa050331.13666297
36* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11010826
37Systemic lupus erythematosus_Homo sapiens_hsa053221.03533323
38p53 signaling pathway_Homo sapiens_hsa041151.03172189
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00086905
40Propanoate metabolism_Homo sapiens_hsa006400.99417721
41Axon guidance_Homo sapiens_hsa043600.98981127
42Alzheimers disease_Homo sapiens_hsa050100.91034988
43Alcoholism_Homo sapiens_hsa050340.83655898
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76041148
45Nitrogen metabolism_Homo sapiens_hsa009100.75711921
46Synaptic vesicle cycle_Homo sapiens_hsa047210.71757235
47Biosynthesis of amino acids_Homo sapiens_hsa012300.71438807
48Viral carcinogenesis_Homo sapiens_hsa052030.70769259
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70558654
50Collecting duct acid secretion_Homo sapiens_hsa049660.69851829
51Amphetamine addiction_Homo sapiens_hsa050310.68299843
52Long-term potentiation_Homo sapiens_hsa047200.67198804
53Phototransduction_Homo sapiens_hsa047440.65273550
54Butanoate metabolism_Homo sapiens_hsa006500.60640682
55Cardiac muscle contraction_Homo sapiens_hsa042600.60236832
56Notch signaling pathway_Homo sapiens_hsa043300.58227671
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55701622
58Hippo signaling pathway_Homo sapiens_hsa043900.54868517
59Sulfur relay system_Homo sapiens_hsa041220.54121683
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54079480
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52896031
62Circadian entrainment_Homo sapiens_hsa047130.52390452
63Pentose phosphate pathway_Homo sapiens_hsa000300.52338244
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51780956
65Hedgehog signaling pathway_Homo sapiens_hsa043400.51201763
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51049171
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50972913
68Morphine addiction_Homo sapiens_hsa050320.50825881
69Regulation of autophagy_Homo sapiens_hsa041400.50540067
70Insulin secretion_Homo sapiens_hsa049110.50162552
71Tight junction_Homo sapiens_hsa045300.49404429
72cAMP signaling pathway_Homo sapiens_hsa040240.47480915
73ErbB signaling pathway_Homo sapiens_hsa040120.46104078
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44767042
75Adherens junction_Homo sapiens_hsa045200.44236524
76Thyroid hormone synthesis_Homo sapiens_hsa049180.44150369
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43773720
78Fatty acid biosynthesis_Homo sapiens_hsa000610.43675417
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42008956
80beta-Alanine metabolism_Homo sapiens_hsa004100.41445884
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41350722
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41022541
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39395358
84Fructose and mannose metabolism_Homo sapiens_hsa000510.39238376
85Olfactory transduction_Homo sapiens_hsa047400.38782096
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38639615
87Glutathione metabolism_Homo sapiens_hsa004800.37435755
88Dopaminergic synapse_Homo sapiens_hsa047280.37429033
89Carbon metabolism_Homo sapiens_hsa012000.36415470
90Vibrio cholerae infection_Homo sapiens_hsa051100.36140810
91Wnt signaling pathway_Homo sapiens_hsa043100.35391061
92* Pathways in cancer_Homo sapiens_hsa052000.35274477
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34912202
94Lysine degradation_Homo sapiens_hsa003100.34656687
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33652741
96Gastric acid secretion_Homo sapiens_hsa049710.32696286
97Dorso-ventral axis formation_Homo sapiens_hsa043200.30111378
98Taste transduction_Homo sapiens_hsa047420.30101911
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30075241
100Folate biosynthesis_Homo sapiens_hsa007900.30037865
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29640486
102Protein export_Homo sapiens_hsa030600.28855302
103Long-term depression_Homo sapiens_hsa047300.28730473
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28644912
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28358344
106Metabolic pathways_Homo sapiens_hsa011000.28022499
107Gap junction_Homo sapiens_hsa045400.27614424
108Arginine and proline metabolism_Homo sapiens_hsa003300.27579727
109HTLV-I infection_Homo sapiens_hsa051660.27576151
110Melanoma_Homo sapiens_hsa052180.27434363
111Selenocompound metabolism_Homo sapiens_hsa004500.26531085
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.26129985
113Basal cell carcinoma_Homo sapiens_hsa052170.26016809
114Colorectal cancer_Homo sapiens_hsa052100.25291645
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24726377
116GABAergic synapse_Homo sapiens_hsa047270.24124841
117MicroRNAs in cancer_Homo sapiens_hsa052060.23534449
118Thyroid cancer_Homo sapiens_hsa052160.23419086
119Serotonergic synapse_Homo sapiens_hsa047260.22947193
120TGF-beta signaling pathway_Homo sapiens_hsa043500.22738701
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.19964615
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.19168581
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18242264
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17415722
125* Estrogen signaling pathway_Homo sapiens_hsa049150.16744183
126Glutamatergic synapse_Homo sapiens_hsa047240.15510517
127* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14580756
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14478590
129mTOR signaling pathway_Homo sapiens_hsa041500.14166398
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.13691678
131* Antigen processing and presentation_Homo sapiens_hsa046120.12582256
132HIF-1 signaling pathway_Homo sapiens_hsa040660.12441518
133Melanogenesis_Homo sapiens_hsa049160.12129722
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.11998992
135Prion diseases_Homo sapiens_hsa050200.11521997
136Renal cell carcinoma_Homo sapiens_hsa052110.11240888
137Pyruvate metabolism_Homo sapiens_hsa006200.11118171

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