ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.79325068
2	DNA deamination (GO:0045006)	5.07318203
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.06046860
4	behavioral response to nicotine (GO:0035095)	4.99394022
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.85560970
6	ATP synthesis coupled proton transport (GO:0015986)	4.85560970
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.57406847
8	protein neddylation (GO:0045116)	4.22526305
9	respiratory electron transport chain (GO:0022904)	4.12228125
10	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.11171686
11	electron transport chain (GO:0022900)	4.10808436
12	protein complex biogenesis (GO:0070271)	3.98494388
13	cytidine deamination (GO:0009972)	3.84234437
14	cytidine metabolic process (GO:0046087)	3.84234437
15	cytidine catabolic process (GO:0006216)	3.84234437
16	chaperone-mediated protein transport (GO:0072321)	3.79342418
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.70129697
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.70129697
19	NADH dehydrogenase complex assembly (GO:0010257)	3.70129697
20	mitochondrial respiratory chain complex assembly (GO:0033108)	3.66639261
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.54590314
22	somite development (GO:0061053)	3.46099783
23	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.32983796
24	response to pheromone (GO:0019236)	3.28801704
25	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.20366129
26	proteasome assembly (GO:0043248)	3.20316316
27	nonmotile primary cilium assembly (GO:0035058)	3.18506333
28	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.12569573
29	hydrogen ion transmembrane transport (GO:1902600)	3.11532526
30	protein-cofactor linkage (GO:0018065)	3.09674165
31	indolalkylamine metabolic process (GO:0006586)	3.05932547
32	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.05868269
33	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.04240252
34	proton transport (GO:0015992)	3.03847860
35	respiratory chain complex IV assembly (GO:0008535)	2.97031461
36	hydrogen transport (GO:0006818)	2.95895541
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.88185469
38	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.88185469
39	intracellular protein transmembrane import (GO:0044743)	2.86486718
40	kynurenine metabolic process (GO:0070189)	2.82401849
41	sequestering of actin monomers (GO:0042989)	2.82224722
42	neuron fate determination (GO:0048664)	2.81938508
43	ATP biosynthetic process (GO:0006754)	2.79835557
44	regulation of hexokinase activity (GO:1903299)	2.79236615
45	regulation of glucokinase activity (GO:0033131)	2.79236615
46	indole-containing compound catabolic process (GO:0042436)	2.79226070
47	indolalkylamine catabolic process (GO:0046218)	2.79226070
48	tryptophan catabolic process (GO:0006569)	2.79226070
49	regulation of action potential (GO:0098900)	2.77845904
50	DNA damage response, detection of DNA damage (GO:0042769)	2.75616296
51	negative regulation of telomere maintenance (GO:0032205)	2.75365416
52	cytochrome complex assembly (GO:0017004)	2.74458007
53	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.70816689
54	platelet dense granule organization (GO:0060155)	2.70694331
55	epithelial cilium movement (GO:0003351)	2.69663500
56	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.69106881
57	ribosomal small subunit assembly (GO:0000028)	2.64035053
58	preassembly of GPI anchor in ER membrane (GO:0016254)	2.62545275
59	protein polyglutamylation (GO:0018095)	2.61761240
60	L-fucose catabolic process (GO:0042355)	2.61464182
61	fucose catabolic process (GO:0019317)	2.61464182
62	L-fucose metabolic process (GO:0042354)	2.61464182
63	piRNA metabolic process (GO:0034587)	2.57455180
64	regulation of cilium movement (GO:0003352)	2.54739759
65	inner mitochondrial membrane organization (GO:0007007)	2.52897662
66	termination of RNA polymerase III transcription (GO:0006386)	2.52488882
67	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.52488882
68	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.52055758
69	cotranslational protein targeting to membrane (GO:0006613)	2.48411786
70	neuronal action potential (GO:0019228)	2.46781123
71	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.45418467
72	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.44699102
73	substrate-independent telencephalic tangential migration (GO:0021826)	2.44699102
74	pyrimidine nucleobase catabolic process (GO:0006208)	2.44454268
75	translational termination (GO:0006415)	2.43675019
76	protein targeting to ER (GO:0045047)	2.43085486
77	organelle disassembly (GO:1903008)	2.42565811
78	indole-containing compound metabolic process (GO:0042430)	2.40252616
79	chromatin remodeling at centromere (GO:0031055)	2.40242378
80	protein K6-linked ubiquitination (GO:0085020)	2.40220526
81	viral transcription (GO:0019083)	2.39783612
82	synaptic transmission, cholinergic (GO:0007271)	2.39746883
83	negative regulation by host of viral transcription (GO:0043922)	2.38298804
84	cell proliferation in forebrain (GO:0021846)	2.37203445
85	negative regulation of T cell differentiation in thymus (GO:0033085)	2.37035932
86	mannosylation (GO:0097502)	2.36885385
87	negative regulation of heart rate (GO:0010459)	2.36289767
88	tryptophan metabolic process (GO:0006568)	2.35178417
89	GTP biosynthetic process (GO:0006183)	2.35132738
90	GPI anchor metabolic process (GO:0006505)	2.34201100
91	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.32332441
92	axoneme assembly (GO:0035082)	2.31099083
93	tRNA processing (GO:0008033)	2.30912175
94	ubiquinone metabolic process (GO:0006743)	2.30534126
95	transmission of nerve impulse (GO:0019226)	2.30299421
96	protein localization to endoplasmic reticulum (GO:0070972)	2.29653442
97	regulation of cellular amino acid metabolic process (GO:0006521)	2.29618633
98	ribosomal large subunit biogenesis (GO:0042273)	2.28847223
99	cilium movement (GO:0003341)	2.28383983
100	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.27401350

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.95673562
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.16484941
3	VDR_22108803_ChIP-Seq_LS180_Human	3.01559967
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.90449745
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.85953528
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.71162820
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.68082971
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.63738160
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.58710632
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.57774226
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.25807688
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.15022729
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.12715417
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.11458871
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08906122
16	EWS_26573619_Chip-Seq_HEK293_Human	2.05994762
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.04783757
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.01194434
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.99326118
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.94455810
21	FUS_26573619_Chip-Seq_HEK293_Human	1.94115139
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88558742
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.88424628
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87430110
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.84999409
26	P300_19829295_ChIP-Seq_ESCs_Human	1.78230143
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.76309512
28	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.71267344
29	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.66029774
30	VDR_23849224_ChIP-Seq_CD4+_Human	1.65669726
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.65204032
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.65102349
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.60874852
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.57728854
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.57185533
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55649606
37	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.52100661
38	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.51450517
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.50925706
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.48578259
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.44859251
42	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.42176123
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42084667
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35608189
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.35608189
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.34884584
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34726689
48	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.33868976
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.32602729
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31030659
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31030659
52	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.30944270
53	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29129033
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28605816
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28286426
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28286426
57	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.27991650
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26800725
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23140847
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21715606
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21715606
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18170396
63	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17238241
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17040526
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16557588
66	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15322276
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13644274
68	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.13531581
69	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12963453
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.11561909
71	SMAD4_21799915_ChIP-Seq_A2780_Human	1.09193908
72	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07839225
73	AR_25329375_ChIP-Seq_VCAP_Human	1.07598821
74	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06565898
75	AR_20517297_ChIP-Seq_VCAP_Human	1.06310627
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05786804
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05520045
78	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05130221
79	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.04770669
80	NCOR_22424771_ChIP-Seq_293T_Human	1.04131507
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04006019
82	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03542376
83	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03002896
84	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.02775198
85	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.02630852
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02258568
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00867077
88	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00121785
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.98662016
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98402229
91	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.96650537
92	RUNX2_22187159_ChIP-Seq_PCA_Human	0.96122510
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96011642
94	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.95748881
95	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.95580036
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95398656
97	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.95257791
98	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.95137022
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94946610
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.93476836

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.03352616
2	MP0009379_abnormal_foot_pigmentation	2.99531480
3	MP0000569_abnormal_digit_pigmentation	2.69425086
4	MP0008877_abnormal_DNA_methylation	2.47679809
5	MP0002102_abnormal_ear_morphology	2.45493912
6	MP0006072_abnormal_retinal_apoptosis	2.39649386
7	MP0003880_abnormal_central_pattern	2.33067146
8	MP0003787_abnormal_imprinting	2.02502261
9	MP0002837_dystrophic_cardiac_calcinosis	2.00616668
10	MP0004142_abnormal_muscle_tone	1.98313811
11	MP0005551_abnormal_eye_electrophysiolog	1.95284163
12	MP0002277_abnormal_respiratory_mucosa	1.93777970
13	MP0004885_abnormal_endolymph	1.92789461
14	MP0001529_abnormal_vocalization	1.91946713
15	MP0005084_abnormal_gallbladder_morpholo	1.90573957
16	MP0005645_abnormal_hypothalamus_physiol	1.90019663
17	MP0001968_abnormal_touch/_nociception	1.88691441
18	MP0005646_abnormal_pituitary_gland	1.84795621
19	MP0001905_abnormal_dopamine_level	1.81664849
20	MP0006276_abnormal_autonomic_nervous	1.80655784
21	MP0005423_abnormal_somatic_nervous	1.78351581
22	MP0004742_abnormal_vestibular_system	1.74080429
23	MP0002272_abnormal_nervous_system	1.73882710
24	MP0002736_abnormal_nociception_after	1.72772927
25	MP0003011_delayed_dark_adaptation	1.71942806
26	MP0009745_abnormal_behavioral_response	1.70730712
27	MP0002163_abnormal_gland_morphology	1.69154900
28	MP0003195_calcinosis	1.68664379
29	MP0001485_abnormal_pinna_reflex	1.66766912
30	MP0002938_white_spotting	1.63375649
31	MP0001188_hyperpigmentation	1.61454931
32	MP0003136_yellow_coat_color	1.60266898
33	MP0000631_abnormal_neuroendocrine_gland	1.58318765
34	MP0004147_increased_porphyrin_level	1.55643325
35	MP0004133_heterotaxia	1.54003309
36	MP0003283_abnormal_digestive_organ	1.52551904
37	MP0008875_abnormal_xenobiotic_pharmacok	1.44331284
38	MP0005253_abnormal_eye_physiology	1.43893578
39	MP0000372_irregular_coat_pigmentation	1.43306176
40	MP0002876_abnormal_thyroid_physiology	1.43185275
41	MP0003122_maternal_imprinting	1.42295700
42	MP0008872_abnormal_physiological_respon	1.41330431
43	MP0005671_abnormal_response_to	1.40759734
44	MP0000778_abnormal_nervous_system	1.38529793
45	MP0003121_genomic_imprinting	1.37111326
46	MP0001486_abnormal_startle_reflex	1.36926185
47	MP0002638_abnormal_pupillary_reflex	1.36741747
48	MP0009046_muscle_twitch	1.28648062
49	MP0002572_abnormal_emotion/affect_behav	1.28203654
50	MP0005379_endocrine/exocrine_gland_phen	1.22745966
51	MP0004145_abnormal_muscle_electrophysio	1.22430905
52	MP0001986_abnormal_taste_sensitivity	1.18670245
53	MP0002095_abnormal_skin_pigmentation	1.17604841
54	MP0003646_muscle_fatigue	1.17135537
55	MP0002064_seizures	1.17131441
56	MP0001970_abnormal_pain_threshold	1.16367049
57	MP0001984_abnormal_olfaction	1.16015580
58	MP0002557_abnormal_social/conspecific_i	1.15774842
59	MP0008789_abnormal_olfactory_epithelium	1.14795204
60	MP0002067_abnormal_sensory_capabilities	1.13321432
61	MP0005389_reproductive_system_phenotype	1.12976206
62	MP0003878_abnormal_ear_physiology	1.12099979
63	MP0005377_hearing/vestibular/ear_phenot	1.12099979
64	MP0003635_abnormal_synaptic_transmissio	1.11569062
65	MP0002733_abnormal_thermal_nociception	1.11538757
66	MP0002653_abnormal_ependyma_morphology	1.11169429
67	MP0001919_abnormal_reproductive_system	1.10950559
68	MP0002184_abnormal_innervation	1.09343585
69	MP0002234_abnormal_pharynx_morphology	1.09318914
70	MP0002734_abnormal_mechanical_nocicepti	1.05885091
71	MP0001293_anophthalmia	1.05605060
72	MP0002160_abnormal_reproductive_system	1.03987364
73	MP0002928_abnormal_bile_duct	1.03919975
74	MP0000026_abnormal_inner_ear	1.02562778
75	MP0010386_abnormal_urinary_bladder	1.02082240
76	MP0004924_abnormal_behavior	1.00675062
77	MP0005386_behavior/neurological_phenoty	1.00675062
78	MP0000049_abnormal_middle_ear	1.00021057
79	MP0005195_abnormal_posterior_eye	0.99456672
80	MP0002751_abnormal_autonomic_nervous	0.99171169
81	MP0001440_abnormal_grooming_behavior	0.99099088
82	MP0005174_abnormal_tail_pigmentation	0.96003401
83	MP0002822_catalepsy	0.95987647
84	MP0000647_abnormal_sebaceous_gland	0.95806209
85	MP0002063_abnormal_learning/memory/cond	0.93905744
86	MP0002752_abnormal_somatic_nervous	0.93839378
87	MP0002735_abnormal_chemical_nociception	0.92687638
88	MP0003137_abnormal_impulse_conducting	0.88698845
89	MP0001501_abnormal_sleep_pattern	0.86289694
90	MP0000566_synostosis	0.82268854
91	MP0001963_abnormal_hearing_physiology	0.81720331
92	MP0003718_maternal_effect	0.81572097
93	MP0003119_abnormal_digestive_system	0.79515422
94	MP0002210_abnormal_sex_determination	0.77779506
95	MP0008995_early_reproductive_senescence	0.77326413
96	MP0000955_abnormal_spinal_cord	0.77022186
97	MP0002909_abnormal_adrenal_gland	0.76955970
98	MP0003890_abnormal_embryonic-extraembry	0.76291872
99	MP0003937_abnormal_limbs/digits/tail_de	0.75309570
100	MP0008058_abnormal_DNA_repair	0.74442358

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.51027395
2	Mitochondrial inheritance (HP:0001427)	3.96604509
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.87040922
4	Progressive macrocephaly (HP:0004481)	3.86729397
5	Acute encephalopathy (HP:0006846)	3.76141399
6	Molar tooth sign on MRI (HP:0002419)	3.60926379
7	Abnormality of midbrain morphology (HP:0002418)	3.60926379
8	Increased hepatocellular lipid droplets (HP:0006565)	3.59284302
9	Increased CSF lactate (HP:0002490)	3.51070669
10	Pancreatic cysts (HP:0001737)	3.43789894
11	Pancreatic fibrosis (HP:0100732)	3.39700972
12	True hermaphroditism (HP:0010459)	3.33777265
13	Congenital stationary night blindness (HP:0007642)	3.22633796
14	Congenital, generalized hypertrichosis (HP:0004540)	3.21353316
15	Lipid accumulation in hepatocytes (HP:0006561)	3.18736402
16	Nephronophthisis (HP:0000090)	2.97539582
17	Medial flaring of the eyebrow (HP:0010747)	2.94691044
18	Hepatocellular necrosis (HP:0001404)	2.87946384
19	Cerebral edema (HP:0002181)	2.85200157
20	Renal Fanconi syndrome (HP:0001994)	2.83053121
21	Hepatic necrosis (HP:0002605)	2.71341766
22	3-Methylglutaconic aciduria (HP:0003535)	2.63154870
23	Optic disc pallor (HP:0000543)	2.58713854
24	Methylmalonic acidemia (HP:0002912)	2.55030088
25	Pendular nystagmus (HP:0012043)	2.43582300
26	Type II lissencephaly (HP:0007260)	2.41513186
27	Abnormality of the renal cortex (HP:0011035)	2.40932309
28	Abnormality of the renal medulla (HP:0100957)	2.40652971
29	Abolished electroretinogram (ERG) (HP:0000550)	2.36603052
30	Gait imbalance (HP:0002141)	2.35439949
31	Increased intramyocellular lipid droplets (HP:0012240)	2.33589977
32	Methylmalonic aciduria (HP:0012120)	2.32205439
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.29829051
34	Sclerocornea (HP:0000647)	2.28466962
35	Exertional dyspnea (HP:0002875)	2.27807518
36	Limb dystonia (HP:0002451)	2.25431884
37	Septo-optic dysplasia (HP:0100842)	2.21108621
38	Congenital primary aphakia (HP:0007707)	2.20484301
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.20207706
40	Abnormal number of erythroid precursors (HP:0012131)	2.17292592
41	Leukodystrophy (HP:0002415)	2.15906234
42	Hypothermia (HP:0002045)	2.15079098
43	Rib fusion (HP:0000902)	2.11922291
44	Supernumerary spleens (HP:0009799)	2.10988912
45	Lethargy (HP:0001254)	2.10019961
46	Nephrogenic diabetes insipidus (HP:0009806)	2.07394489
47	Abnormality of the labia minora (HP:0012880)	2.07080054
48	Abnormality of cells of the erythroid lineage (HP:0012130)	2.06924999
49	Male pseudohermaphroditism (HP:0000037)	2.06617815
50	Renal cortical cysts (HP:0000803)	2.06595381
51	Abnormality of renal resorption (HP:0011038)	2.06339044
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.04925747
53	Lactic acidosis (HP:0003128)	2.04820793
54	Increased serum lactate (HP:0002151)	2.03549882
55	Abnormal ciliary motility (HP:0012262)	2.03541974
56	Abnormality of alanine metabolism (HP:0010916)	2.03273667
57	Hyperalaninemia (HP:0003348)	2.03273667
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.03273667
59	Abnormal respiratory motile cilium morphology (HP:0005938)	2.02883176
60	Abnormal respiratory epithelium morphology (HP:0012253)	2.02883176
61	Absent/shortened dynein arms (HP:0200106)	2.00884251
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.00884251
63	Anencephaly (HP:0002323)	2.00541636
64	Glycosuria (HP:0003076)	2.00071145
65	Abnormality of urine glucose concentration (HP:0011016)	2.00071145
66	Hyperglycinemia (HP:0002154)	1.98380467
67	Abnormal respiratory motile cilium physiology (HP:0012261)	1.95072423
68	Focal motor seizures (HP:0011153)	1.92007515
69	Median cleft lip (HP:0000161)	1.89471314
70	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.88801231
71	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.88801231
72	Cystic liver disease (HP:0006706)	1.87632607
73	Abnormal drinking behavior (HP:0030082)	1.87578699
74	Polydipsia (HP:0001959)	1.87578699
75	Decreased central vision (HP:0007663)	1.86486483
76	Genital tract atresia (HP:0001827)	1.84863794
77	Macrocytic anemia (HP:0001972)	1.84742183
78	Respiratory failure (HP:0002878)	1.83319958
79	Short tibia (HP:0005736)	1.82541182
80	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.81557610
81	Concave nail (HP:0001598)	1.81202924
82	Vaginal atresia (HP:0000148)	1.80988420
83	Postaxial foot polydactyly (HP:0001830)	1.80758872
84	Attenuation of retinal blood vessels (HP:0007843)	1.78939442
85	Optic nerve hypoplasia (HP:0000609)	1.78487538
86	Postaxial hand polydactyly (HP:0001162)	1.77776745
87	Hypoplasia of the pons (HP:0012110)	1.76462032
88	Reticulocytopenia (HP:0001896)	1.76278649
89	Abnormality of the pons (HP:0007361)	1.74658085
90	Increased muscle lipid content (HP:0009058)	1.73455590
91	IgG deficiency (HP:0004315)	1.71647511
92	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.71631217
93	Tubular atrophy (HP:0000092)	1.71275650
94	Aplastic anemia (HP:0001915)	1.70838748
95	Lissencephaly (HP:0001339)	1.70580332
96	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.70308610
97	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.69543914
98	Furrowed tongue (HP:0000221)	1.69431202
99	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.68964213
100	Bilateral microphthalmos (HP:0007633)	1.67136712

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.25980099
2	TSSK6	2.89392013
3	ZAK	2.53964023
4	WEE1	2.50502502
5	FRK	2.43289383
6	NUAK1	2.39950293
7	ADRBK2	2.33507016
8	WNK3	2.20679926
9	GRK1	2.07184615
10	MAPK15	2.03766931
11	MAP4K2	1.96088112
12	VRK1	1.95834178
13	VRK2	1.94702740
14	CASK	1.94521726
15	PINK1	1.93274200
16	TXK	1.86169409
17	TNIK	1.78754408
18	MAPK13	1.77804347
19	WNK4	1.70461665
20	TLK1	1.70315207
21	TAOK3	1.60312272
22	DYRK2	1.60028870
23	TRIM28	1.48431608
24	BMPR1B	1.47812363
25	STK16	1.43488152
26	MST4	1.43150006
27	MARK1	1.33335692
28	TAF1	1.31624313
29	INSRR	1.29055183
30	BCKDK	1.27948926
31	OXSR1	1.24999247
32	MAP2K7	1.18636542
33	STK39	1.18429373
34	BUB1	1.14410833
35	PLK3	1.12440676
36	CDC7	1.11539251
37	MKNK2	1.08687015
38	BCR	1.07293653
39	MAP3K4	1.07015352
40	MAP3K12	1.03387920
41	TIE1	1.01459670
42	NTRK2	0.98939177
43	NTRK3	0.98262035
44	PRKCG	0.94305412
45	NME1	0.91896943
46	ERBB3	0.89974005
47	MAPKAPK5	0.86580285
48	CSNK1G2	0.85032225
49	EPHB2	0.83414380
50	KDR	0.81823722
51	CDK3	0.81801709
52	SRPK1	0.78605346
53	PLK2	0.78545599
54	CSNK1G3	0.78130799
55	PHKG1	0.76120530
56	PHKG2	0.76120530
57	MAP2K6	0.73511279
58	CSNK1G1	0.72471449
59	EIF2AK3	0.70988111
60	LIMK1	0.70164170
61	PRKCE	0.68958520
62	PAK3	0.67773945
63	RPS6KA5	0.67424134
64	PIK3CA	0.66619888
65	MINK1	0.63735107
66	PRKCQ	0.62799397
67	MKNK1	0.62709275
68	CAMKK2	0.62306586
69	BRSK2	0.62162976
70	NEK1	0.61366649
71	DYRK3	0.61064675
72	PASK	0.58411581
73	CDK19	0.58337117
74	CSNK1A1L	0.57256101
75	DAPK2	0.56805519
76	UHMK1	0.56335182
77	TEC	0.55695067
78	CAMK2A	0.54555854
79	ADRBK1	0.53733040
80	PRKACA	0.53731877
81	MUSK	0.53580686
82	ITK	0.53085563
83	PLK4	0.49321404
84	PLK1	0.47905881
85	CSNK1A1	0.46501362
86	OBSCN	0.43675124
87	FES	0.42476505
88	CSNK2A1	0.42405880
89	ATR	0.41625594
90	TESK2	0.40089276
91	CSNK2A2	0.39622616
92	PKN1	0.38702951
93	ACVR1B	0.38034476
94	IKBKB	0.37702151
95	CSNK1E	0.36673725
96	PRKG1	0.36247917
97	CAMK2D	0.35028835
98	TNK2	0.34786318
99	PRKCA	0.34326255
100	AURKA	0.33190705

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.26717272
2	Parkinsons disease_Homo sapiens_hsa05012	3.59231856
3	Protein export_Homo sapiens_hsa03060	3.40025702
4	Proteasome_Homo sapiens_hsa03050	3.13908656
5	Ribosome_Homo sapiens_hsa03010	3.01301419
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.38391966
7	Alzheimers disease_Homo sapiens_hsa05010	2.37853560
8	Huntingtons disease_Homo sapiens_hsa05016	2.34239957
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.19567987
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.13219479
11	Phototransduction_Homo sapiens_hsa04744	2.08824225
12	RNA polymerase_Homo sapiens_hsa03020	2.01242225
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99842335
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.98623271
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.88564353
16	Caffeine metabolism_Homo sapiens_hsa00232	1.73153853
17	Nicotine addiction_Homo sapiens_hsa05033	1.70998335
18	Basal transcription factors_Homo sapiens_hsa03022	1.66867813
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.65710727
20	Homologous recombination_Homo sapiens_hsa03440	1.64302388
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51087125
22	Butanoate metabolism_Homo sapiens_hsa00650	1.47293815
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.45662841
24	RNA degradation_Homo sapiens_hsa03018	1.43555245
25	Propanoate metabolism_Homo sapiens_hsa00640	1.35744720
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33048223
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.32054787
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.31771053
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25673700
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.21646819
31	Asthma_Homo sapiens_hsa05310	1.20830002
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.20267230
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.18707524
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.14744892
35	Spliceosome_Homo sapiens_hsa03040	1.02122113
36	Olfactory transduction_Homo sapiens_hsa04740	1.01633358
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99871254
38	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98440550
39	One carbon pool by folate_Homo sapiens_hsa00670	0.95714081
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.95631931
41	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.95173733
42	Taste transduction_Homo sapiens_hsa04742	0.94424847
43	Steroid biosynthesis_Homo sapiens_hsa00100	0.93096643
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.92315806
45	Peroxisome_Homo sapiens_hsa04146	0.91478637
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.89162605
47	Allograft rejection_Homo sapiens_hsa05330	0.89145677
48	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.85946216
49	Antigen processing and presentation_Homo sapiens_hsa04612	0.84809771
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.84124491
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83318309
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.83216681
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.78941972
54	Rheumatoid arthritis_Homo sapiens_hsa05323	0.78487764
55	GABAergic synapse_Homo sapiens_hsa04727	0.78083304
56	Morphine addiction_Homo sapiens_hsa05032	0.77263364
57	Purine metabolism_Homo sapiens_hsa00230	0.76916041
58	Insulin secretion_Homo sapiens_hsa04911	0.76178867
59	Regulation of autophagy_Homo sapiens_hsa04140	0.74788511
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74214196
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74072875
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71399012
63	Retinol metabolism_Homo sapiens_hsa00830	0.71039996
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.71020871
65	RNA transport_Homo sapiens_hsa03013	0.70313755
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67558233
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.67309832
68	Mismatch repair_Homo sapiens_hsa03430	0.66898199
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61923469
70	Folate biosynthesis_Homo sapiens_hsa00790	0.61151490
71	Metabolic pathways_Homo sapiens_hsa01100	0.60467964
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.60274726
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59103630
74	Sulfur metabolism_Homo sapiens_hsa00920	0.59042286
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57081589
76	Glutamatergic synapse_Homo sapiens_hsa04724	0.53776235
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53699920
78	Serotonergic synapse_Homo sapiens_hsa04726	0.52229098
79	Cocaine addiction_Homo sapiens_hsa05030	0.51844547
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48112819
81	Mineral absorption_Homo sapiens_hsa04978	0.46230494
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.46181427
83	Circadian entrainment_Homo sapiens_hsa04713	0.44973803
84	Amphetamine addiction_Homo sapiens_hsa05031	0.44399634
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43784149
86	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43445247
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42764123
88	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42412820
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.40144126
90	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40045400
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.38636205
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.36828626
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.35651858
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34017974
95	Dopaminergic synapse_Homo sapiens_hsa04728	0.33528284
96	Salivary secretion_Homo sapiens_hsa04970	0.33188576
97	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.32023243
98	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.29946555
99	DNA replication_Homo sapiens_hsa03030	0.28521084
100	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.26381074

HSP90AA2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »