ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.46764185
2	response to pheromone (GO:0019236)	5.26608350
3	behavioral response to nicotine (GO:0035095)	5.25703086
4	DNA deamination (GO:0045006)	4.96156413
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.86202750
6	ATP synthesis coupled proton transport (GO:0015986)	4.80719019
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.80719019
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.07370656
9	protein complex biogenesis (GO:0070271)	4.04000243
10	sperm motility (GO:0030317)	3.96363630
11	rRNA modification (GO:0000154)	3.94737518
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.92413864
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.92027318
14	NADH dehydrogenase complex assembly (GO:0010257)	3.92027318
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.92027318
16	proteasome assembly (GO:0043248)	3.87206487
17	acrosome reaction (GO:0007340)	3.81478903
18	mitochondrial respiratory chain complex assembly (GO:0033108)	3.80524797
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.74430198
20	protein neddylation (GO:0045116)	3.64929804
21	rRNA methylation (GO:0031167)	3.57145794
22	cellular ketone body metabolic process (GO:0046950)	3.55339663
23	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.54400922
24	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.53570595
25	chaperone-mediated protein transport (GO:0072321)	3.52109574
26	respiratory chain complex IV assembly (GO:0008535)	3.51330095
27	epithelial cilium movement (GO:0003351)	3.50671585
28	respiratory electron transport chain (GO:0022904)	3.47523865
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.46233883
30	electron transport chain (GO:0022900)	3.45333547
31	cytidine deamination (GO:0009972)	3.45000788
32	cytidine metabolic process (GO:0046087)	3.45000788
33	cytidine catabolic process (GO:0006216)	3.45000788
34	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.38221210
35	termination of RNA polymerase III transcription (GO:0006386)	3.38221210
36	axonemal dynein complex assembly (GO:0070286)	3.27213857
37	L-fucose catabolic process (GO:0042355)	3.26204530
38	fucose catabolic process (GO:0019317)	3.26204530
39	L-fucose metabolic process (GO:0042354)	3.26204530
40	protein-cofactor linkage (GO:0018065)	3.21338225
41	ketone body metabolic process (GO:1902224)	3.18321280
42	fusion of sperm to egg plasma membrane (GO:0007342)	3.18244460
43	protein polyglutamylation (GO:0018095)	3.17824783
44	regulation of cilium movement (GO:0003352)	3.13089926
45	DNA damage response, detection of DNA damage (GO:0042769)	3.08118073
46	centriole replication (GO:0007099)	3.04761188
47	single strand break repair (GO:0000012)	3.03576138
48	microtubule depolymerization (GO:0007019)	2.99762792
49	cytochrome complex assembly (GO:0017004)	2.97471553
50	intracellular protein transmembrane import (GO:0044743)	2.94696664
51	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.91796358
52	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.91796358
53	sperm-egg recognition (GO:0035036)	2.88507842
54	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.87120537
55	protein refolding (GO:0042026)	2.85640817
56	plasma membrane fusion (GO:0045026)	2.82826976
57	multicellular organism reproduction (GO:0032504)	2.82445316
58	DNA double-strand break processing (GO:0000729)	2.80630121
59	histone exchange (GO:0043486)	2.79648478
60	maturation of 5.8S rRNA (GO:0000460)	2.79201717
61	hydrogen ion transmembrane transport (GO:1902600)	2.79150986
62	GTP biosynthetic process (GO:0006183)	2.78360850
63	spermatid development (GO:0007286)	2.77053888
64	cilium movement (GO:0003341)	2.70065161
65	chromatin remodeling at centromere (GO:0031055)	2.68071001
66	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.67720722
67	rRNA catabolic process (GO:0016075)	2.67318013
68	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.67147540
69	ribosomal large subunit biogenesis (GO:0042273)	2.66498330
70	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.64703453
71	piRNA metabolic process (GO:0034587)	2.64034256
72	pseudouridine synthesis (GO:0001522)	2.62329535
73	proton transport (GO:0015992)	2.61613497
74	ATP biosynthetic process (GO:0006754)	2.60390590
75	resolution of meiotic recombination intermediates (GO:0000712)	2.57045623
76	protein K6-linked ubiquitination (GO:0085020)	2.56534385
77	viral transcription (GO:0019083)	2.56212363
78	translational termination (GO:0006415)	2.55248370
79	maturation of SSU-rRNA (GO:0030490)	2.54556673
80	hydrogen transport (GO:0006818)	2.52719821
81	male meiosis I (GO:0007141)	2.51968313
82	preassembly of GPI anchor in ER membrane (GO:0016254)	2.51024564
83	positive regulation of gastrulation (GO:2000543)	2.50466313
84	somite development (GO:0061053)	2.50245892
85	CENP-A containing nucleosome assembly (GO:0034080)	2.49895123
86	synapsis (GO:0007129)	2.49460433
87	tRNA processing (GO:0008033)	2.49125274
88	nephron epithelium morphogenesis (GO:0072088)	2.49047463
89	nephron tubule morphogenesis (GO:0072078)	2.49047463
90	rRNA metabolic process (GO:0016072)	2.48598053
91	calcium ion-dependent exocytosis (GO:0017156)	2.47594588
92	rRNA processing (GO:0006364)	2.47376027
93	regulation of cellular amino acid metabolic process (GO:0006521)	2.47064186
94	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.46183156
95	adaptation of signaling pathway (GO:0023058)	2.45010218
96	axoneme assembly (GO:0035082)	2.43549494
97	cotranslational protein targeting to membrane (GO:0006613)	2.42692360
98	histone mRNA metabolic process (GO:0008334)	2.41636078
99	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.40245473
100	ncRNA catabolic process (GO:0034661)	2.39836035

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.29484757
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.20487594
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.14065544
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.01839726
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.94871856
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.79372217
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.72608405
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.63349086
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.60516074
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53798109
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.47215317
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.23297176
13	FUS_26573619_Chip-Seq_HEK293_Human	2.23258819
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21336936
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.12230243
16	EWS_26573619_Chip-Seq_HEK293_Human	1.89302364
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88810628
18	P300_19829295_ChIP-Seq_ESCs_Human	1.83187304
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.82189844
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.79189987
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.77438741
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.77407798
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.77401379
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.76544508
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.76330628
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.75732500
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.75524918
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.72596311
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.69437700
30	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.68588221
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.68042813
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.65158842
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.59920346
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.55049931
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52297992
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.50755522
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49121519
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.46562667
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.43753261
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39855453
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.39855453
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39714021
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.35359575
44	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.35080006
45	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.34799215
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34475082
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34435188
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34435188
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29969252
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29969252
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27991068
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25832211
53	FOXP3_21729870_ChIP-Seq_TREG_Human	1.24381991
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24373441
55	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.24057155
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23632049
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23632049
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.22804401
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.22686097
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22236585
61	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.21734572
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.20319932
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18710209
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17329453
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16763624
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15654812
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14302179
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.13252475
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09961936
70	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.09919780
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.08594832
72	NCOR_22424771_ChIP-Seq_293T_Human	1.08544813
73	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.07420891
74	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.07148511
75	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.06493264
76	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04429450
77	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.04273743
78	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04038735
79	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.02798076
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02077836
81	ETV1_20927104_ChIP-Seq_GIST48_Human	1.01358355
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01071502
83	MYC_19829295_ChIP-Seq_ESCs_Human	1.01001782
84	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00588023
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00411944
86	RBPJ_21746931_ChIP-Seq_IB4_Human	1.00159104
87	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.99563134
88	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99335589
89	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98948847
90	TAF2_19829295_ChIP-Seq_ESCs_Human	0.98529132
91	AR_20517297_ChIP-Seq_VCAP_Human	0.98472752
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97846572
93	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97195683
94	PHF8_20622853_ChIP-Seq_HELA_Human	0.96610183
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96047913
96	TTF2_22483619_ChIP-Seq_HELA_Human	0.96018526
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.95980114
98	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.95236009
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95153934
100	AR_25329375_ChIP-Seq_VCAP_Human	0.93713317

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.02274228
2	MP0003136_yellow_coat_color	3.02243535
3	MP0005410_abnormal_fertilization	2.75397018
4	MP0006292_abnormal_olfactory_placode	2.70459545
5	MP0003787_abnormal_imprinting	2.39046380
6	MP0006072_abnormal_retinal_apoptosis	2.16560533
7	MP0003283_abnormal_digestive_organ	2.16159315
8	MP0009379_abnormal_foot_pigmentation	2.09165762
9	MP0004142_abnormal_muscle_tone	2.05790254
10	MP0003878_abnormal_ear_physiology	2.04435419
11	MP0005377_hearing/vestibular/ear_phenot	2.04435419
12	MP0001968_abnormal_touch/_nociception	2.02245405
13	MP0001485_abnormal_pinna_reflex	1.89411281
14	MP0002837_dystrophic_cardiac_calcinosis	1.86925947
15	MP0005084_abnormal_gallbladder_morpholo	1.81049343
16	MP0005551_abnormal_eye_electrophysiolog	1.78549953
17	MP0004885_abnormal_endolymph	1.78296361
18	MP0003011_delayed_dark_adaptation	1.70863088
19	MP0003880_abnormal_central_pattern	1.70431313
20	MP0002277_abnormal_respiratory_mucosa	1.67670730
21	MP0002272_abnormal_nervous_system	1.65119249
22	MP0002938_white_spotting	1.61288302
23	MP0002735_abnormal_chemical_nociception	1.60853943
24	MP0002736_abnormal_nociception_after	1.60375489
25	MP0009745_abnormal_behavioral_response	1.57780019
26	MP0004742_abnormal_vestibular_system	1.57140481
27	MP0005646_abnormal_pituitary_gland	1.56009797
28	MP0005379_endocrine/exocrine_gland_phen	1.55832155
29	MP0003195_calcinosis	1.53021987
30	MP0002102_abnormal_ear_morphology	1.51609897
31	MP0000569_abnormal_digit_pigmentation	1.51333927
32	MP0003718_maternal_effect	1.51050307
33	MP0001529_abnormal_vocalization	1.48869162
34	MP0005253_abnormal_eye_physiology	1.48151736
35	MP0003121_genomic_imprinting	1.47626406
36	MP0008872_abnormal_physiological_respon	1.43260328
37	MP0006276_abnormal_autonomic_nervous	1.37160485
38	MP0000631_abnormal_neuroendocrine_gland	1.35646416
39	MP0005671_abnormal_response_to	1.35532577
40	MP0002638_abnormal_pupillary_reflex	1.34916869
41	MP0000372_irregular_coat_pigmentation	1.34060883
42	MP0001486_abnormal_startle_reflex	1.33546853
43	MP0002163_abnormal_gland_morphology	1.32667359
44	MP0003698_abnormal_male_reproductive	1.32360120
45	MP0005645_abnormal_hypothalamus_physiol	1.32106606
46	MP0001929_abnormal_gametogenesis	1.31510198
47	MP0005423_abnormal_somatic_nervous	1.28600190
48	MP0002653_abnormal_ependyma_morphology	1.27605099
49	MP0001984_abnormal_olfaction	1.26952730
50	MP0001502_abnormal_circadian_rhythm	1.26149093
51	MP0004145_abnormal_muscle_electrophysio	1.26028566
52	MP0001905_abnormal_dopamine_level	1.23061093
53	MP0001970_abnormal_pain_threshold	1.20854506
54	MP0008875_abnormal_xenobiotic_pharmacok	1.19913318
55	MP0009046_muscle_twitch	1.16427518
56	MP0004147_increased_porphyrin_level	1.14844812
57	MP0002733_abnormal_thermal_nociception	1.14717678
58	MP0008995_early_reproductive_senescence	1.14149721
59	MP0000566_synostosis	1.12586696
60	MP0000049_abnormal_middle_ear	1.12549655
61	MP0002572_abnormal_emotion/affect_behav	1.09652997
62	MP0002557_abnormal_social/conspecific_i	1.09638298
63	MP0003122_maternal_imprinting	1.08858777
64	MP0002067_abnormal_sensory_capabilities	1.08433535
65	MP0002234_abnormal_pharynx_morphology	1.07265472
66	MP0008058_abnormal_DNA_repair	1.06825940
67	MP0001293_anophthalmia	1.06244889
68	MP0002210_abnormal_sex_determination	1.04455355
69	MP0005389_reproductive_system_phenotype	1.02363551
70	MP0002751_abnormal_autonomic_nervous	0.98821617
71	MP0002064_seizures	0.98062194
72	MP0002282_abnormal_trachea_morphology	0.97906662
73	MP0002160_abnormal_reproductive_system	0.97254715
74	MP0003119_abnormal_digestive_system	0.96375662
75	MP0001919_abnormal_reproductive_system	0.95678817
76	MP0002184_abnormal_innervation	0.94639853
77	MP0001873_stomach_inflammation	0.92969935
78	MP0000778_abnormal_nervous_system	0.89216756
79	MP0000026_abnormal_inner_ear	0.88737921
80	MP0002752_abnormal_somatic_nervous	0.88656433
81	MP0001440_abnormal_grooming_behavior	0.88499425
82	MP0001501_abnormal_sleep_pattern	0.88474851
83	MP0003635_abnormal_synaptic_transmissio	0.88217541
84	MP0003937_abnormal_limbs/digits/tail_de	0.87809247
85	MP0001986_abnormal_taste_sensitivity	0.86921356
86	MP0002876_abnormal_thyroid_physiology	0.86270779
87	MP0003646_muscle_fatigue	0.85441248
88	MP0005195_abnormal_posterior_eye	0.84684054
89	MP0003567_abnormal_fetal_cardiomyocyte	0.81733379
90	MP0002095_abnormal_skin_pigmentation	0.81357129
91	MP0005670_abnormal_white_adipose	0.80540391
92	MP0000955_abnormal_spinal_cord	0.80461777
93	MP0000653_abnormal_sex_gland	0.79420926
94	MP0008007_abnormal_cellular_replicative	0.79061597
95	MP0001348_abnormal_lacrimal_gland	0.78565743
96	MP0001963_abnormal_hearing_physiology	0.78513629
97	MP0001188_hyperpigmentation	0.78143593
98	MP0010386_abnormal_urinary_bladder	0.76854369
99	MP0008789_abnormal_olfactory_epithelium	0.76817731
100	MP0002693_abnormal_pancreas_physiology	0.75878760

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.82425334
2	Increased hepatocellular lipid droplets (HP:0006565)	3.48645548
3	Abnormality of midbrain morphology (HP:0002418)	3.41939907
4	Molar tooth sign on MRI (HP:0002419)	3.41939907
5	Mitochondrial inheritance (HP:0001427)	3.39197336
6	Congenital, generalized hypertrichosis (HP:0004540)	3.29413239
7	Lipid accumulation in hepatocytes (HP:0006561)	3.25156507
8	Acute encephalopathy (HP:0006846)	3.23763039
9	Congenital stationary night blindness (HP:0007642)	3.21747466
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.17363093
11	Increased CSF lactate (HP:0002490)	3.16102326
12	Renal Fanconi syndrome (HP:0001994)	3.14891228
13	Progressive macrocephaly (HP:0004481)	3.10406233
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.09240137
15	Absent/shortened dynein arms (HP:0200106)	3.09240137
16	Pancreatic cysts (HP:0001737)	3.02143488
17	Nephronophthisis (HP:0000090)	2.96852488
18	Abnormal respiratory epithelium morphology (HP:0012253)	2.83498422
19	Abnormal respiratory motile cilium morphology (HP:0005938)	2.83498422
20	Abnormality of the labia minora (HP:0012880)	2.82306513
21	Abnormality of the pons (HP:0007361)	2.77540091
22	Type II lissencephaly (HP:0007260)	2.75373293
23	Pancreatic fibrosis (HP:0100732)	2.72755434
24	Septo-optic dysplasia (HP:0100842)	2.68552832
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.61288389
26	Hepatocellular necrosis (HP:0001404)	2.60828623
27	Optic disc pallor (HP:0000543)	2.60324227
28	Cerebral edema (HP:0002181)	2.57010093
29	Hypoplasia of the pons (HP:0012110)	2.56065794
30	True hermaphroditism (HP:0010459)	2.54516313
31	Abnormal ciliary motility (HP:0012262)	2.50848179
32	Medial flaring of the eyebrow (HP:0010747)	2.42493806
33	Abnormality of the renal medulla (HP:0100957)	2.41778258
34	Type 2 muscle fiber atrophy (HP:0003554)	2.40872215
35	3-Methylglutaconic aciduria (HP:0003535)	2.37808751
36	Hepatic necrosis (HP:0002605)	2.37656854
37	Pendular nystagmus (HP:0012043)	2.34015410
38	Large for gestational age (HP:0001520)	2.33415663
39	Abnormality of the renal cortex (HP:0011035)	2.31647042
40	Rib fusion (HP:0000902)	2.23656741
41	Methylmalonic acidemia (HP:0002912)	2.22147309
42	Abnormality of renal resorption (HP:0011038)	2.22045371
43	Sclerocornea (HP:0000647)	2.19664899
44	Attenuation of retinal blood vessels (HP:0007843)	2.17126228
45	Optic nerve hypoplasia (HP:0000609)	2.15348927
46	Abnormal respiratory motile cilium physiology (HP:0012261)	2.13631331
47	Increased serum lactate (HP:0002151)	2.08528842
48	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.06724134
49	Polydipsia (HP:0001959)	2.06383215
50	Abnormal drinking behavior (HP:0030082)	2.06383215
51	Exertional dyspnea (HP:0002875)	2.06335435
52	Bilateral microphthalmos (HP:0007633)	2.05477252
53	Methylmalonic aciduria (HP:0012120)	2.03531434
54	Glycosuria (HP:0003076)	2.03405011
55	Abnormality of urine glucose concentration (HP:0011016)	2.03405011
56	Cerebellar dysplasia (HP:0007033)	2.02800586
57	Muscle fiber atrophy (HP:0100295)	2.01126221
58	IgG deficiency (HP:0004315)	2.00293131
59	Leukodystrophy (HP:0002415)	1.99010958
60	Polyuria (HP:0000103)	1.97650364
61	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.95071395
62	Median cleft lip (HP:0000161)	1.94454205
63	Reticulocytopenia (HP:0001896)	1.92098671
64	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.89369866
65	Abnormality of alanine metabolism (HP:0010916)	1.89369866
66	Hyperalaninemia (HP:0003348)	1.89369866
67	Increased intramyocellular lipid droplets (HP:0012240)	1.89349188
68	Absent septum pellucidum (HP:0001331)	1.89006391
69	Anophthalmia (HP:0000528)	1.88034521
70	Abolished electroretinogram (ERG) (HP:0000550)	1.85754701
71	Renal cortical cysts (HP:0000803)	1.84499137
72	Hyperglycinuria (HP:0003108)	1.83126313
73	Abnormality of macular pigmentation (HP:0008002)	1.83005884
74	Bony spicule pigmentary retinopathy (HP:0007737)	1.82820517
75	Severe visual impairment (HP:0001141)	1.82420144
76	Amniotic constriction ring (HP:0009775)	1.82355288
77	Abnormality of placental membranes (HP:0011409)	1.82355288
78	Lethargy (HP:0001254)	1.79583540
79	Adrenal hypoplasia (HP:0000835)	1.79386435
80	Abnormal number of incisors (HP:0011064)	1.79240793
81	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77998297
82	Decreased central vision (HP:0007663)	1.77229550
83	Lissencephaly (HP:0001339)	1.77179048
84	Abnormal number of erythroid precursors (HP:0012131)	1.76538398
85	Lactic acidosis (HP:0003128)	1.76272125
86	Abnormality of cells of the erythroid lineage (HP:0012130)	1.74201038
87	Abnormal urine output (HP:0012590)	1.71863993
88	Hyperphosphaturia (HP:0003109)	1.71755946
89	Parakeratosis (HP:0001036)	1.71458221
90	Esophageal atresia (HP:0002032)	1.70653309
91	Macrocytic anemia (HP:0001972)	1.69330136
92	Respiratory difficulties (HP:0002880)	1.69130158
93	Maternal diabetes (HP:0009800)	1.66907493
94	Gait imbalance (HP:0002141)	1.66269978
95	Azoospermia (HP:0000027)	1.65235014
96	Focal motor seizures (HP:0011153)	1.64183794
97	Severe muscular hypotonia (HP:0006829)	1.64090978
98	Hypothermia (HP:0002045)	1.64089827
99	Febrile seizures (HP:0002373)	1.63936316
100	Colon cancer (HP:0003003)	1.63495535

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	4.68641518
2	ZAK	3.00424382
3	TSSK6	2.90621610
4	TLK1	2.71537978
5	WNK4	2.64089427
6	TXK	2.49219248
7	BMPR1B	2.46938723
8	ADRBK2	2.33583388
9	WEE1	2.20144421
10	INSRR	2.09964057
11	STK39	2.07182777
12	VRK1	2.05205388
13	MST4	2.03424226
14	WNK3	2.02063813
15	TRIM28	1.96995009
16	VRK2	1.96528848
17	FRK	1.85277277
18	STK16	1.81055980
19	MAP4K2	1.80799366
20	NUAK1	1.79689270
21	PLK4	1.78806209
22	GRK1	1.64528988
23	OXSR1	1.63501891
24	TAOK3	1.56174739
25	TNIK	1.53038736
26	PINK1	1.46751361
27	TAF1	1.42250002
28	MAP3K4	1.41076052
29	MAPK15	1.37572911
30	PRKCG	1.27215685
31	MKNK2	1.25528429
32	MAP2K7	1.25071578
33	DYRK2	1.21092915
34	BUB1	1.20748797
35	PLK3	1.19615530
36	PLK2	1.15621264
37	ACVR1B	1.11105284
38	BCKDK	1.10873060
39	MAPK13	1.06657561
40	SRPK1	1.06492195
41	EIF2AK1	1.01911527
42	MARK1	1.00546138
43	EIF2AK3	0.99853131
44	TIE1	0.99462333
45	NME1	0.98119126
46	CASK	0.95042803
47	PASK	0.92776468
48	PHKG2	0.89556752
49	PHKG1	0.89556752
50	MAPKAPK5	0.83347401
51	MAP2K6	0.78043280
52	NEK1	0.75011650
53	GRK7	0.72534022
54	MKNK1	0.72236682
55	PRKCE	0.70995351
56	WNK1	0.66572581
57	ADRBK1	0.64645495
58	IKBKB	0.62053910
59	TGFBR1	0.57357830
60	PLK1	0.56414031
61	NTRK3	0.56027511
62	CDC7	0.55372941
63	NTRK2	0.52939034
64	CDK3	0.51733217
65	TEC	0.51712380
66	STK38L	0.50939941
67	CSNK1G2	0.48581065
68	TNK2	0.47877957
69	PRKACA	0.47179271
70	EIF2AK2	0.46796585
71	CAMKK2	0.45598224
72	DAPK2	0.44954564
73	CSNK1E	0.44892132
74	MAP3K12	0.44384356
75	PRKG1	0.44139255
76	CAMK2A	0.43939068
77	MUSK	0.41037735
78	GRK5	0.40336707
79	TYRO3	0.40104746
80	PRKCQ	0.39941830
81	CSNK2A2	0.38531167
82	AURKA	0.37562847
83	CSNK2A1	0.36893295
84	CDK19	0.36384279
85	DYRK3	0.35999022
86	PKN1	0.34740881
87	MAP2K4	0.34722546
88	MINK1	0.33275604
89	CSNK1A1	0.32629539
90	SIK2	0.32226311
91	PIK3CA	0.32091350
92	ATR	0.31515116
93	BCR	0.31505426
94	PRKCA	0.31221117
95	CAMK1	0.31149054
96	PAK3	0.30713847
97	RPS6KA5	0.28949413
98	SYK	0.28787995
99	CHEK2	0.28486293
100	FGFR1	0.28191243

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.71706881
2	Proteasome_Homo sapiens_hsa03050	3.62189242
3	Parkinsons disease_Homo sapiens_hsa05012	3.18084188
4	Ribosome_Homo sapiens_hsa03010	3.11043241
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.87592028
6	Protein export_Homo sapiens_hsa03060	2.82232627
7	RNA polymerase_Homo sapiens_hsa03020	2.54716087
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.20213500
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.19257576
10	Huntingtons disease_Homo sapiens_hsa05016	2.15596283
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.10327264
12	Alzheimers disease_Homo sapiens_hsa05010	2.03619229
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.89618623
14	Homologous recombination_Homo sapiens_hsa03440	1.86036268
15	RNA degradation_Homo sapiens_hsa03018	1.84387363
16	Basal transcription factors_Homo sapiens_hsa03022	1.78024366
17	Propanoate metabolism_Homo sapiens_hsa00640	1.74521758
18	Phototransduction_Homo sapiens_hsa04744	1.71906593
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.68061834
20	Butanoate metabolism_Homo sapiens_hsa00650	1.59633027
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58206870
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.47480839
23	Nicotine addiction_Homo sapiens_hsa05033	1.44874378
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.41328992
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.40728018
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.35722699
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.35352245
28	Allograft rejection_Homo sapiens_hsa05330	1.32852237
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.30467399
30	Asthma_Homo sapiens_hsa05310	1.29097353
31	Olfactory transduction_Homo sapiens_hsa04740	1.26632764
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.26192363
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24267154
34	Spliceosome_Homo sapiens_hsa03040	1.23573410
35	RNA transport_Homo sapiens_hsa03013	1.20217697
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.19803500
37	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.15587182
38	Mismatch repair_Homo sapiens_hsa03430	1.13902229
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13363473
40	Caffeine metabolism_Homo sapiens_hsa00232	1.12193554
41	Graft-versus-host disease_Homo sapiens_hsa05332	1.12139960
42	One carbon pool by folate_Homo sapiens_hsa00670	1.10056803
43	Purine metabolism_Homo sapiens_hsa00230	1.09593733
44	Antigen processing and presentation_Homo sapiens_hsa04612	1.05674737
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.03205087
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.00861401
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00821824
48	Taste transduction_Homo sapiens_hsa04742	0.99676503
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.99388106
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.94407109
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.94212519
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.93534595
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.89936049
54	Primary immunodeficiency_Homo sapiens_hsa05340	0.83025739
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81594050
56	DNA replication_Homo sapiens_hsa03030	0.81322355
57	Morphine addiction_Homo sapiens_hsa05032	0.77979469
58	Peroxisome_Homo sapiens_hsa04146	0.76201189
59	GABAergic synapse_Homo sapiens_hsa04727	0.74163442
60	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.74000917
61	Folate biosynthesis_Homo sapiens_hsa00790	0.67039671
62	Retinol metabolism_Homo sapiens_hsa00830	0.66335380
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64928439
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.64680025
65	Sulfur metabolism_Homo sapiens_hsa00920	0.64346648
66	Metabolic pathways_Homo sapiens_hsa01100	0.62902526
67	Insulin secretion_Homo sapiens_hsa04911	0.58234228
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57339067
69	Regulation of autophagy_Homo sapiens_hsa04140	0.56300906
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55820666
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55702230
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54430494
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.54007663
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.53944715
75	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53701513
76	Pyruvate metabolism_Homo sapiens_hsa00620	0.52079731
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51433739
78	Circadian entrainment_Homo sapiens_hsa04713	0.49251080
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49071961
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.46718190
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45607553
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43711355
83	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.43370981
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42433215
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42294369
86	Glutamatergic synapse_Homo sapiens_hsa04724	0.39340723
87	Serotonergic synapse_Homo sapiens_hsa04726	0.39279895
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38754462
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38548356
90	Fatty acid degradation_Homo sapiens_hsa00071	0.37359848
91	Mineral absorption_Homo sapiens_hsa04978	0.36445719
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.36431074
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.35273642
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.32553866
95	Non-homologous end-joining_Homo sapiens_hsa03450	0.30787233
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30735027
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.28670272
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27664845
99	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.26499178
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25557533

HSP90AA4P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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