HSP90AA5P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.76521889
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.74693460
3mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.42759692
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.42759692
5NADH dehydrogenase complex assembly (GO:0010257)4.42759692
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27152751
7ATP synthesis coupled proton transport (GO:0015986)4.27152751
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26663605
9protein complex biogenesis (GO:0070271)4.23325116
10response to pheromone (GO:0019236)4.22614187
11mitochondrial respiratory chain complex assembly (GO:0033108)3.85399536
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.82430807
13water-soluble vitamin biosynthetic process (GO:0042364)3.77816558
14respiratory chain complex IV assembly (GO:0008535)3.70672918
15platelet dense granule organization (GO:0060155)3.49533933
16DNA double-strand break processing (GO:0000729)3.44599579
17peptidyl-histidine modification (GO:0018202)3.43398629
18chaperone-mediated protein transport (GO:0072321)3.42268456
19protein neddylation (GO:0045116)3.40086419
20respiratory electron transport chain (GO:0022904)3.30020884
21electron transport chain (GO:0022900)3.28682650
22aldehyde catabolic process (GO:0046185)3.27863945
23intracellular protein transmembrane import (GO:0044743)3.26854682
24DNA deamination (GO:0045006)3.24827937
25cellular ketone body metabolic process (GO:0046950)3.22449283
26neuron fate determination (GO:0048664)3.18833995
27indolalkylamine metabolic process (GO:0006586)3.12185264
28proteasome assembly (GO:0043248)3.04554862
29cullin deneddylation (GO:0010388)3.00791138
30negative regulation of DNA-dependent DNA replication (GO:2000104)2.96432500
31GTP biosynthetic process (GO:0006183)2.96073363
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.95389410
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94583800
34ketone body metabolic process (GO:1902224)2.93031623
35cytochrome complex assembly (GO:0017004)2.92016808
36detection of light stimulus involved in sensory perception (GO:0050962)2.82613846
37detection of light stimulus involved in visual perception (GO:0050908)2.82613846
38purine nucleoside triphosphate biosynthetic process (GO:0009145)2.81583891
39polyol catabolic process (GO:0046174)2.79979073
40protein deneddylation (GO:0000338)2.76411434
41purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.74076894
42replication fork processing (GO:0031297)2.72566726
43transcription elongation from RNA polymerase I promoter (GO:0006362)2.69996305
44regulation of DNA endoreduplication (GO:0032875)2.69175738
45prenylation (GO:0097354)2.69006387
46protein prenylation (GO:0018342)2.69006387
47indole-containing compound catabolic process (GO:0042436)2.67511861
48indolalkylamine catabolic process (GO:0046218)2.67511861
49tryptophan catabolic process (GO:0006569)2.67511861
50ATP biosynthetic process (GO:0006754)2.67130640
51somite development (GO:0061053)2.66869129
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64659355
53intraciliary transport (GO:0042073)2.63946523
54tryptophan metabolic process (GO:0006568)2.61918561
55positive regulation of prostaglandin secretion (GO:0032308)2.60788720
56rRNA modification (GO:0000154)2.59274872
57rRNA methylation (GO:0031167)2.58687407
58protein localization to cilium (GO:0061512)2.58284498
59parental behavior (GO:0060746)2.57483797
60positive regulation of protein homodimerization activity (GO:0090073)2.56806986
61retinal cone cell development (GO:0046549)2.55023818
62mannosylation (GO:0097502)2.52309312
63keratinocyte development (GO:0003334)2.51907990
64nucleobase catabolic process (GO:0046113)2.51366878
65termination of RNA polymerase III transcription (GO:0006386)2.51264757
66transcription elongation from RNA polymerase III promoter (GO:0006385)2.51264757
67hydrogen ion transmembrane transport (GO:1902600)2.51165740
68inositol phosphate catabolic process (GO:0071545)2.47198799
69signal peptide processing (GO:0006465)2.47051105
70maturation of 5.8S rRNA (GO:0000460)2.46576678
71nonmotile primary cilium assembly (GO:0035058)2.46516454
72intracellular protein transmembrane transport (GO:0065002)2.45976804
73UTP biosynthetic process (GO:0006228)2.43560526
74termination of RNA polymerase I transcription (GO:0006363)2.41908088
75glycosphingolipid biosynthetic process (GO:0006688)2.40752644
76proton transport (GO:0015992)2.39684614
77pyrimidine nucleobase catabolic process (GO:0006208)2.38674896
78gamma-aminobutyric acid transport (GO:0015812)2.37291437
79maternal behavior (GO:0042711)2.37042983
80hydrogen transport (GO:0006818)2.35072391
81protein-cofactor linkage (GO:0018065)2.32468521
82UTP metabolic process (GO:0046051)2.29896029
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.29482322
84dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.29410877
85anterograde synaptic vesicle transport (GO:0048490)2.28988619
86telomere maintenance via telomerase (GO:0007004)2.28939675
87preassembly of GPI anchor in ER membrane (GO:0016254)2.28699625
88recombinational repair (GO:0000725)2.28615563
89double-strand break repair via homologous recombination (GO:0000724)2.28447153
90ribonucleoside triphosphate biosynthetic process (GO:0009201)2.27073079
91inositol phosphate dephosphorylation (GO:0046855)2.26382032
92phosphorylated carbohydrate dephosphorylation (GO:0046838)2.26382032
93cellular biogenic amine catabolic process (GO:0042402)2.25453764
94amine catabolic process (GO:0009310)2.25453764
95protein transmembrane transport (GO:0071806)2.24193399
96regulation of meiosis I (GO:0060631)2.22874704
97synaptic transmission, cholinergic (GO:0007271)2.22475552
98DNA damage response, detection of DNA damage (GO:0042769)2.22472047
99tRNA processing (GO:0008033)2.22194459
100nucleoside diphosphate phosphorylation (GO:0006165)2.21962813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.42998823
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.42330165
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14927500
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.09971356
5ZNF274_21170338_ChIP-Seq_K562_Hela3.02278428
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.95554087
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94822650
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.85264088
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73159792
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62638670
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50711305
12EZH2_22144423_ChIP-Seq_EOC_Human2.49944474
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44989930
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.44281969
15EWS_26573619_Chip-Seq_HEK293_Human2.32834751
16FUS_26573619_Chip-Seq_HEK293_Human2.24840102
17TAF15_26573619_Chip-Seq_HEK293_Human2.23251311
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17803448
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.11215493
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06799616
21P300_19829295_ChIP-Seq_ESCs_Human2.04697229
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87522424
23GBX2_23144817_ChIP-Seq_PC3_Human1.86598511
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83231015
25ELK1_19687146_ChIP-ChIP_HELA_Human1.82724822
26IGF1R_20145208_ChIP-Seq_DFB_Human1.77979614
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77952762
28IRF1_19129219_ChIP-ChIP_H3396_Human1.76495826
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71547553
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.65019038
31VDR_23849224_ChIP-Seq_CD4+_Human1.64592635
32ER_23166858_ChIP-Seq_MCF-7_Human1.62630187
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53509663
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49870617
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.46225744
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43535849
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40950866
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40900581
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39975265
40BCAT_22108803_ChIP-Seq_LS180_Human1.39042204
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38843162
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.38388669
43AR_25329375_ChIP-Seq_VCAP_Human1.36036721
44NANOG_19829295_ChIP-Seq_ESCs_Human1.35260768
45SOX2_19829295_ChIP-Seq_ESCs_Human1.35260768
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34839941
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.33490249
48TCF4_22108803_ChIP-Seq_LS180_Human1.33107225
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32978587
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32412506
51SMAD4_21799915_ChIP-Seq_A2780_Human1.32066101
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31521863
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31100640
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30176803
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.29877555
56MYC_18940864_ChIP-ChIP_HL60_Human1.27390780
57TP53_22573176_ChIP-Seq_HFKS_Human1.25275316
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.22279626
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22153074
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19284672
61REST_21632747_ChIP-Seq_MESCs_Mouse1.17129433
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16287514
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15648303
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14353298
65CBP_20019798_ChIP-Seq_JUKART_Human1.12928356
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12928356
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12711359
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.12711359
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.12661417
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11928272
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11783207
72RNF2_27304074_Chip-Seq_NSC_Mouse1.09916728
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09905465
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09905465
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09548663
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.08429213
77FOXP3_21729870_ChIP-Seq_TREG_Human1.08363742
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08012180
79NCOR_22424771_ChIP-Seq_293T_Human1.07743490
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07546498
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.06425401
82P53_22387025_ChIP-Seq_ESCs_Mouse1.05929388
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04488288
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.04406047
85TCF4_23295773_ChIP-Seq_U87_Human1.04352809
86AR_21572438_ChIP-Seq_LNCaP_Human1.03312500
87STAT3_23295773_ChIP-Seq_U87_Human1.02025333
88RUNX2_22187159_ChIP-Seq_PCA_Human0.99324275
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99074546
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98787619
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98107286
92CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97495468
93PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96331686
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95466223
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95464268
96HTT_18923047_ChIP-ChIP_STHdh_Human0.94472459
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94285124
98AR_20517297_ChIP-Seq_VCAP_Human0.93853411
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93144552
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.92294803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.85890297
2MP0003136_yellow_coat_color3.64098231
3MP0003787_abnormal_imprinting2.75867384
4MP0008877_abnormal_DNA_methylation2.69056833
5MP0006292_abnormal_olfactory_placode2.64204035
6MP0000372_irregular_coat_pigmentation2.53948631
7MP0003195_calcinosis2.49840109
8MP0003121_genomic_imprinting2.41982338
9MP0003122_maternal_imprinting2.40731566
10MP0002102_abnormal_ear_morphology2.28193730
11MP0008058_abnormal_DNA_repair2.26171040
12MP0004142_abnormal_muscle_tone2.23404939
13MP0005645_abnormal_hypothalamus_physiol2.17828614
14MP0002638_abnormal_pupillary_reflex2.04224766
15MP0002938_white_spotting2.03765301
16MP0005551_abnormal_eye_electrophysiolog1.99390342
17MP0002653_abnormal_ependyma_morphology1.95574923
18MP0001984_abnormal_olfaction1.94577357
19MP0004885_abnormal_endolymph1.89904995
20MP0006072_abnormal_retinal_apoptosis1.76314849
21MP0001485_abnormal_pinna_reflex1.69684114
22MP0000569_abnormal_digit_pigmentation1.67347594
23MP0005646_abnormal_pituitary_gland1.66227367
24MP0002876_abnormal_thyroid_physiology1.61918471
25MP0001529_abnormal_vocalization1.60894704
26MP0009046_muscle_twitch1.58910544
27MP0002163_abnormal_gland_morphology1.58264735
28MP0001188_hyperpigmentation1.57088925
29MP0005379_endocrine/exocrine_gland_phen1.56952256
30MP0009745_abnormal_behavioral_response1.56880873
31MP0006276_abnormal_autonomic_nervous1.56212267
32MP0002272_abnormal_nervous_system1.51970480
33MP0001486_abnormal_startle_reflex1.48737134
34MP0001986_abnormal_taste_sensitivity1.47045288
35MP0008872_abnormal_physiological_respon1.42949678
36MP0005174_abnormal_tail_pigmentation1.41745676
37MP0000631_abnormal_neuroendocrine_gland1.40175763
38MP0003718_maternal_effect1.37862306
39MP0005253_abnormal_eye_physiology1.36119433
40MP0001968_abnormal_touch/_nociception1.36028302
41MP0002557_abnormal_social/conspecific_i1.30378951
42MP0005084_abnormal_gallbladder_morpholo1.28130915
43MP0008789_abnormal_olfactory_epithelium1.27828721
44MP0002909_abnormal_adrenal_gland1.27331942
45MP0002572_abnormal_emotion/affect_behav1.26574826
46MP0001970_abnormal_pain_threshold1.25033665
47MP0003880_abnormal_central_pattern1.21791655
48MP0002064_seizures1.21676849
49MP0002734_abnormal_mechanical_nocicepti1.21437938
50MP0002095_abnormal_skin_pigmentation1.20414826
51MP0002090_abnormal_vision1.20263443
52MP0009379_abnormal_foot_pigmentation1.20252591
53MP0001919_abnormal_reproductive_system1.19951599
54MP0002733_abnormal_thermal_nociception1.18804385
55MP0001501_abnormal_sleep_pattern1.18524375
56MP0003123_paternal_imprinting1.18058733
57MP0004145_abnormal_muscle_electrophysio1.17214049
58MP0008875_abnormal_xenobiotic_pharmacok1.16574131
59MP0005332_abnormal_amino_acid1.15062510
60MP0002736_abnormal_nociception_after1.13483430
61MP0005389_reproductive_system_phenotype1.12445499
62MP0004134_abnormal_chest_morphology1.10308574
63MP0004043_abnormal_pH_regulation1.10034471
64MP0009697_abnormal_copulation1.09795214
65MP0002751_abnormal_autonomic_nervous1.09626767
66MP0002160_abnormal_reproductive_system1.07571060
67MP0010386_abnormal_urinary_bladder1.06954591
68MP0002277_abnormal_respiratory_mucosa1.02395262
69MP0000778_abnormal_nervous_system1.00528607
70MP0001440_abnormal_grooming_behavior0.99923527
71MP0002735_abnormal_chemical_nociception0.99687199
72MP0003011_delayed_dark_adaptation0.98250865
73MP0002693_abnormal_pancreas_physiology0.96161884
74MP0000613_abnormal_salivary_gland0.95928691
75MP0005386_behavior/neurological_phenoty0.95914850
76MP0004924_abnormal_behavior0.95914850
77MP0003635_abnormal_synaptic_transmissio0.95330932
78MP0005195_abnormal_posterior_eye0.94585030
79MP0006035_abnormal_mitochondrial_morpho0.93396551
80MP0000427_abnormal_hair_cycle0.90642283
81MP0002063_abnormal_learning/memory/cond0.90505672
82MP0005187_abnormal_penis_morphology0.90256004
83MP0004215_abnormal_myocardial_fiber0.89653995
84MP0001944_abnormal_pancreas_morphology0.88277818
85MP0002184_abnormal_innervation0.86693647
86MP0002928_abnormal_bile_duct0.85562543
87MP0000955_abnormal_spinal_cord0.85228439
88MP0000015_abnormal_ear_pigmentation0.84995718
89MP0005423_abnormal_somatic_nervous0.83936948
90MP0005171_absent_coat_pigmentation0.82226113
91MP0001905_abnormal_dopamine_level0.80759295
92MP0005499_abnormal_olfactory_system0.78947771
93MP0005394_taste/olfaction_phenotype0.78947771
94MP0002067_abnormal_sensory_capabilities0.76413501
95MP0003119_abnormal_digestive_system0.76317090
96MP0004270_analgesia0.76090300
97MP0002229_neurodegeneration0.75495664
98MP0000371_diluted_coat_color0.75053716
99MP0002752_abnormal_somatic_nervous0.73317085
100MP0002138_abnormal_hepatobiliary_system0.72737937

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.06205014
2Progressive macrocephaly (HP:0004481)3.78420444
3Acute encephalopathy (HP:0006846)3.67610676
4Mitochondrial inheritance (HP:0001427)3.58262439
5Increased CSF lactate (HP:0002490)3.53646672
6Abnormal mitochondria in muscle tissue (HP:0008316)3.37112526
7True hermaphroditism (HP:0010459)3.34396598
8Abnormality of the labia minora (HP:0012880)3.28473934
9Nephronophthisis (HP:0000090)3.22098228
10Hypothermia (HP:0002045)3.20705560
11Pancreatic fibrosis (HP:0100732)3.13625307
12Molar tooth sign on MRI (HP:0002419)2.99320547
13Abnormality of midbrain morphology (HP:0002418)2.99320547
14Congenital stationary night blindness (HP:0007642)2.93096464
15Pancreatic cysts (HP:0001737)2.89528715
16Hepatocellular necrosis (HP:0001404)2.80529705
17Hyperventilation (HP:0002883)2.78260602
18Increased hepatocellular lipid droplets (HP:0006565)2.77262202
19Lipid accumulation in hepatocytes (HP:0006561)2.74167437
20Cerebral edema (HP:0002181)2.66932060
21Hepatic necrosis (HP:0002605)2.63757653
22Methylmalonic acidemia (HP:0002912)2.54372023
23Abnormality of the renal medulla (HP:0100957)2.51959379
24Optic disc pallor (HP:0000543)2.50512649
25Pendular nystagmus (HP:0012043)2.49440262
26Congenital, generalized hypertrichosis (HP:0004540)2.48797261
27Colon cancer (HP:0003003)2.48410116
283-Methylglutaconic aciduria (HP:0003535)2.38775894
29Medial flaring of the eyebrow (HP:0010747)2.34744160
30Volvulus (HP:0002580)2.33982493
31Sclerocornea (HP:0000647)2.31910334
32Methylmalonic aciduria (HP:0012120)2.30856306
33Abnormality of vitamin B metabolism (HP:0004340)2.24063190
34Renal Fanconi syndrome (HP:0001994)2.22431461
35Chronic hepatic failure (HP:0100626)2.18906336
36Hyperinsulinemic hypoglycemia (HP:0000825)2.18304727
37Abnormality of the renal cortex (HP:0011035)2.17868984
38Exertional dyspnea (HP:0002875)2.17206215
39Increased serum lactate (HP:0002151)2.11852232
40Type II lissencephaly (HP:0007260)2.09140331
41Male pseudohermaphroditism (HP:0000037)2.09018028
42Abnormality of urine glucose concentration (HP:0011016)2.08478203
43Glycosuria (HP:0003076)2.08478203
44Hyperglycinemia (HP:0002154)2.07797086
45Neoplasm of the adrenal cortex (HP:0100641)2.05836693
46Hyperglycinuria (HP:0003108)2.04312632
47Respiratory failure (HP:0002878)2.04195500
48Lethargy (HP:0001254)2.04036470
49Abnormality of macular pigmentation (HP:0008002)2.01263183
50Median cleft lip (HP:0000161)2.00225678
51Abnormal rod and cone electroretinograms (HP:0008323)2.00135298
52Lactic acidosis (HP:0003128)1.99868542
53Neoplasm of the adrenal gland (HP:0100631)1.97517246
54Septo-optic dysplasia (HP:0100842)1.97180155
55Leukodystrophy (HP:0002415)1.96232482
56Aplasia/Hypoplasia of the fovea (HP:0008060)1.94545882
57Hypoplasia of the fovea (HP:0007750)1.94545882
58Hyperphosphaturia (HP:0003109)1.91958078
59Lissencephaly (HP:0001339)1.91508553
60Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91487670
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91487670
62Aplasia/Hypoplasia of the tibia (HP:0005772)1.89780891
63Tubular atrophy (HP:0000092)1.86644323
64Gait imbalance (HP:0002141)1.86340566
65Large for gestational age (HP:0001520)1.85698017
66Abnormal hair whorl (HP:0010721)1.85017569
67Gaze-evoked nystagmus (HP:0000640)1.84413356
68Hypomagnesemia (HP:0002917)1.83846026
69Zonular cataract (HP:0010920)1.80926020
70Hypoglycemic coma (HP:0001325)1.79805058
71Abolished electroretinogram (ERG) (HP:0000550)1.79704067
72Polydipsia (HP:0001959)1.78868070
73Abnormal drinking behavior (HP:0030082)1.78868070
74Inability to walk (HP:0002540)1.78476631
75Short tibia (HP:0005736)1.78210942
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.77569937
77Aplasia/Hypoplasia of the tongue (HP:0010295)1.76802136
78Attenuation of retinal blood vessels (HP:0007843)1.76780620
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76654750
80Cystic liver disease (HP:0006706)1.76596076
81Optic nerve hypoplasia (HP:0000609)1.76075230
82Epileptic encephalopathy (HP:0200134)1.75842629
83Ketosis (HP:0001946)1.75593717
84Pachygyria (HP:0001302)1.75530256
85Congenital primary aphakia (HP:0007707)1.74281295
86Furrowed tongue (HP:0000221)1.73325926
87Abnormality of serine family amino acid metabolism (HP:0010894)1.73071545
88Abnormality of glycine metabolism (HP:0010895)1.73071545
89X-linked dominant inheritance (HP:0001423)1.71768696
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71067757
91Concave nail (HP:0001598)1.70864137
92Agitation (HP:0000713)1.70657143
93Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70480116
94Polyphagia (HP:0002591)1.68931379
95Meckel diverticulum (HP:0002245)1.68206886
96Delayed CNS myelination (HP:0002188)1.67890171
97Hypochromic microcytic anemia (HP:0004840)1.67587825
98Abnormality of the vitamin B12 metabolism (HP:0004341)1.67436042
99Focal motor seizures (HP:0011153)1.67409012
100Poor suck (HP:0002033)1.66728044

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.31761884
2PNCK3.49668885
3TRIM282.98209468
4BMPR1B2.89237279
5TSSK62.70944745
6WNK32.68862095
7NUAK12.53963151
8ACVR1B2.41045215
9MKNK22.35832106
10VRK22.23512537
11GRK12.23369210
12ZAK2.09033430
13STK161.91937110
14WEE11.89674088
15CASK1.88601906
16EIF2AK11.85402471
17MKNK11.84818392
18TNIK1.75544363
19EIF2AK31.73760033
20VRK11.72296153
21MST41.65459870
22TAF11.62489704
23STK241.47415044
24MAPK131.42284841
25PLK31.40038918
26PLK21.38632825
27MAP3K41.37999802
28NEK11.34053997
29MAPK151.32009728
30TLK11.29418003
31ADRBK21.26177166
32WNK41.23302935
33DYRK21.21446269
34PHKG11.15914236
35PHKG21.15914236
36PRKCG1.09195155
37ERBB31.08416291
38MAPKAPK51.06079118
39BUB11.05317153
40CSNK1G21.05310983
41CSNK1G11.03331915
42MAPKAPK31.02694124
43CSNK1A1L1.01660755
44MAP2K71.01518928
45CSNK1G30.99829059
46DYRK30.91880893
47STK38L0.91246723
48NME10.90660497
49MAP4K20.87459829
50STK390.87108659
51OXSR10.86522151
52AKT30.84563700
53CDC70.80671381
54TGFBR10.79516042
55BCKDK0.77227314
56PLK40.76073226
57FGFR20.74127545
58INSRR0.74032035
59TAOK30.73514711
60PRKCE0.72979035
61STK30.72010775
62BCR0.71633337
63PINK10.71268451
64EPHA30.66515146
65PBK0.65035778
66NLK0.60149360
67PAK30.59701712
68PLK10.55536002
69CAMK2A0.52207366
70TXK0.51931025
71GRK50.50777090
72RPS6KA50.48710492
73ADRBK10.48450383
74CSNK1E0.48237273
75TIE10.47649163
76MAP3K120.46398033
77DYRK1A0.46258344
78EIF2AK20.45236438
79CSNK1A10.44752013
80PASK0.44614720
81ERBB20.43162591
82PRKACA0.42293616
83MAP2K60.42267895
84NTRK30.41540780
85CCNB10.41403787
86PRKG10.40380251
87MARK10.39711536
88CSNK2A20.38697125
89PRKCI0.38111376
90ATM0.37736385
91ABL20.37375590
92CSNK2A10.33577131
93PRKACB0.33156173
94CAMK10.32989487
95AURKA0.32210552
96CDK80.31899855
97DAPK20.31081844
98PDK20.30514539
99CAMK1D0.28540522
100PKN10.27606245

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.76970145
2Oxidative phosphorylation_Homo sapiens_hsa001903.42659042
3Proteasome_Homo sapiens_hsa030502.93972769
4Parkinsons disease_Homo sapiens_hsa050122.78069770
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76752485
6Propanoate metabolism_Homo sapiens_hsa006402.32694179
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.16395100
8Butanoate metabolism_Homo sapiens_hsa006502.06403439
9Alzheimers disease_Homo sapiens_hsa050101.86272359
10Huntingtons disease_Homo sapiens_hsa050161.86114529
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83232524
12RNA polymerase_Homo sapiens_hsa030201.82958912
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80448294
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79368300
15Basal transcription factors_Homo sapiens_hsa030221.75772468
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74112268
17Phototransduction_Homo sapiens_hsa047441.71920790
18Ribosome_Homo sapiens_hsa030101.71670029
19Tryptophan metabolism_Homo sapiens_hsa003801.70377049
20Homologous recombination_Homo sapiens_hsa034401.69476731
21Nitrogen metabolism_Homo sapiens_hsa009101.64082306
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64044498
23Cardiac muscle contraction_Homo sapiens_hsa042601.63106073
24Fanconi anemia pathway_Homo sapiens_hsa034601.59856187
25One carbon pool by folate_Homo sapiens_hsa006701.59714743
26Nicotine addiction_Homo sapiens_hsa050331.51523149
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49516638
28Sulfur metabolism_Homo sapiens_hsa009201.42954179
29Peroxisome_Homo sapiens_hsa041461.42010702
30Linoleic acid metabolism_Homo sapiens_hsa005911.39772339
31RNA degradation_Homo sapiens_hsa030181.39337695
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.38944003
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38091383
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32358732
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27099956
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19584603
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07581405
38beta-Alanine metabolism_Homo sapiens_hsa004101.07556904
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06321306
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03459269
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02870591
42Insulin secretion_Homo sapiens_hsa049111.02762334
43Chemical carcinogenesis_Homo sapiens_hsa052040.99107416
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98443157
45Ether lipid metabolism_Homo sapiens_hsa005650.96521454
46Selenocompound metabolism_Homo sapiens_hsa004500.95997685
47Retinol metabolism_Homo sapiens_hsa008300.95950098
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95374532
49Collecting duct acid secretion_Homo sapiens_hsa049660.94082970
50Folate biosynthesis_Homo sapiens_hsa007900.94020909
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92358244
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.90779797
53Fatty acid degradation_Homo sapiens_hsa000710.89921742
54Mismatch repair_Homo sapiens_hsa034300.88437224
55Purine metabolism_Homo sapiens_hsa002300.85259839
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.83213776
57Spliceosome_Homo sapiens_hsa030400.82079559
58RNA transport_Homo sapiens_hsa030130.81697953
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78421045
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76826222
61Steroid biosynthesis_Homo sapiens_hsa001000.76624445
62Vitamin B6 metabolism_Homo sapiens_hsa007500.76499862
63Fat digestion and absorption_Homo sapiens_hsa049750.75938912
64Nucleotide excision repair_Homo sapiens_hsa034200.75414592
65Metabolic pathways_Homo sapiens_hsa011000.74620424
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73633468
67Non-homologous end-joining_Homo sapiens_hsa034500.73112106
68Morphine addiction_Homo sapiens_hsa050320.70266706
69Olfactory transduction_Homo sapiens_hsa047400.69641163
70Taste transduction_Homo sapiens_hsa047420.69477677
71Pyrimidine metabolism_Homo sapiens_hsa002400.68826072
72GABAergic synapse_Homo sapiens_hsa047270.67729030
73Pyruvate metabolism_Homo sapiens_hsa006200.66853541
74Fatty acid elongation_Homo sapiens_hsa000620.65407062
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64920288
76Fatty acid metabolism_Homo sapiens_hsa012120.64369758
77Type I diabetes mellitus_Homo sapiens_hsa049400.60644278
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59654597
79Caffeine metabolism_Homo sapiens_hsa002320.56020134
80Serotonergic synapse_Homo sapiens_hsa047260.54811877
81Glutathione metabolism_Homo sapiens_hsa004800.54078818
82Vitamin digestion and absorption_Homo sapiens_hsa049770.51966760
83Arginine and proline metabolism_Homo sapiens_hsa003300.51815957
84Regulation of autophagy_Homo sapiens_hsa041400.47081348
85Mineral absorption_Homo sapiens_hsa049780.46836513
86Starch and sucrose metabolism_Homo sapiens_hsa005000.43917160
87Arginine biosynthesis_Homo sapiens_hsa002200.42965688
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41964213
89DNA replication_Homo sapiens_hsa030300.41653153
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41227270
91Glutamatergic synapse_Homo sapiens_hsa047240.39897763
92Arachidonic acid metabolism_Homo sapiens_hsa005900.37043140
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36874026
94Glycerolipid metabolism_Homo sapiens_hsa005610.36765828
95Hedgehog signaling pathway_Homo sapiens_hsa043400.35713784
96Amphetamine addiction_Homo sapiens_hsa050310.34763132
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.34347613
98Asthma_Homo sapiens_hsa053100.33068579
99Circadian entrainment_Homo sapiens_hsa047130.32345970
100Cocaine addiction_Homo sapiens_hsa050300.31486503

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