ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.76521889
2	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.74693460
3	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.42759692
4	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.42759692
5	NADH dehydrogenase complex assembly (GO:0010257)	4.42759692
6	ATP synthesis coupled proton transport (GO:0015986)	4.27152751
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.27152751
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.26663605
9	protein complex biogenesis (GO:0070271)	4.23325116
10	response to pheromone (GO:0019236)	4.22614187
11	mitochondrial respiratory chain complex assembly (GO:0033108)	3.85399536
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.82430807
13	water-soluble vitamin biosynthetic process (GO:0042364)	3.77816558
14	respiratory chain complex IV assembly (GO:0008535)	3.70672918
15	platelet dense granule organization (GO:0060155)	3.49533933
16	DNA double-strand break processing (GO:0000729)	3.44599579
17	peptidyl-histidine modification (GO:0018202)	3.43398629
18	chaperone-mediated protein transport (GO:0072321)	3.42268456
19	protein neddylation (GO:0045116)	3.40086419
20	respiratory electron transport chain (GO:0022904)	3.30020884
21	electron transport chain (GO:0022900)	3.28682650
22	aldehyde catabolic process (GO:0046185)	3.27863945
23	intracellular protein transmembrane import (GO:0044743)	3.26854682
24	DNA deamination (GO:0045006)	3.24827937
25	cellular ketone body metabolic process (GO:0046950)	3.22449283
26	neuron fate determination (GO:0048664)	3.18833995
27	indolalkylamine metabolic process (GO:0006586)	3.12185264
28	proteasome assembly (GO:0043248)	3.04554862
29	cullin deneddylation (GO:0010388)	3.00791138
30	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.96432500
31	GTP biosynthetic process (GO:0006183)	2.96073363
32	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.95389410
33	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.94583800
34	ketone body metabolic process (GO:1902224)	2.93031623
35	cytochrome complex assembly (GO:0017004)	2.92016808
36	detection of light stimulus involved in sensory perception (GO:0050962)	2.82613846
37	detection of light stimulus involved in visual perception (GO:0050908)	2.82613846
38	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.81583891
39	polyol catabolic process (GO:0046174)	2.79979073
40	protein deneddylation (GO:0000338)	2.76411434
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.74076894
42	replication fork processing (GO:0031297)	2.72566726
43	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.69996305
44	regulation of DNA endoreduplication (GO:0032875)	2.69175738
45	prenylation (GO:0097354)	2.69006387
46	protein prenylation (GO:0018342)	2.69006387
47	indole-containing compound catabolic process (GO:0042436)	2.67511861
48	indolalkylamine catabolic process (GO:0046218)	2.67511861
49	tryptophan catabolic process (GO:0006569)	2.67511861
50	ATP biosynthetic process (GO:0006754)	2.67130640
51	somite development (GO:0061053)	2.66869129
52	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.64659355
53	intraciliary transport (GO:0042073)	2.63946523
54	tryptophan metabolic process (GO:0006568)	2.61918561
55	positive regulation of prostaglandin secretion (GO:0032308)	2.60788720
56	rRNA modification (GO:0000154)	2.59274872
57	rRNA methylation (GO:0031167)	2.58687407
58	protein localization to cilium (GO:0061512)	2.58284498
59	parental behavior (GO:0060746)	2.57483797
60	positive regulation of protein homodimerization activity (GO:0090073)	2.56806986
61	retinal cone cell development (GO:0046549)	2.55023818
62	mannosylation (GO:0097502)	2.52309312
63	keratinocyte development (GO:0003334)	2.51907990
64	nucleobase catabolic process (GO:0046113)	2.51366878
65	termination of RNA polymerase III transcription (GO:0006386)	2.51264757
66	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.51264757
67	hydrogen ion transmembrane transport (GO:1902600)	2.51165740
68	inositol phosphate catabolic process (GO:0071545)	2.47198799
69	signal peptide processing (GO:0006465)	2.47051105
70	maturation of 5.8S rRNA (GO:0000460)	2.46576678
71	nonmotile primary cilium assembly (GO:0035058)	2.46516454
72	intracellular protein transmembrane transport (GO:0065002)	2.45976804
73	UTP biosynthetic process (GO:0006228)	2.43560526
74	termination of RNA polymerase I transcription (GO:0006363)	2.41908088
75	glycosphingolipid biosynthetic process (GO:0006688)	2.40752644
76	proton transport (GO:0015992)	2.39684614
77	pyrimidine nucleobase catabolic process (GO:0006208)	2.38674896
78	gamma-aminobutyric acid transport (GO:0015812)	2.37291437
79	maternal behavior (GO:0042711)	2.37042983
80	hydrogen transport (GO:0006818)	2.35072391
81	protein-cofactor linkage (GO:0018065)	2.32468521
82	UTP metabolic process (GO:0046051)	2.29896029
83	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.29482322
84	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.29410877
85	anterograde synaptic vesicle transport (GO:0048490)	2.28988619
86	telomere maintenance via telomerase (GO:0007004)	2.28939675
87	preassembly of GPI anchor in ER membrane (GO:0016254)	2.28699625
88	recombinational repair (GO:0000725)	2.28615563
89	double-strand break repair via homologous recombination (GO:0000724)	2.28447153
90	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.27073079
91	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.26382032
92	inositol phosphate dephosphorylation (GO:0046855)	2.26382032
93	cellular biogenic amine catabolic process (GO:0042402)	2.25453764
94	amine catabolic process (GO:0009310)	2.25453764
95	protein transmembrane transport (GO:0071806)	2.24193399
96	regulation of meiosis I (GO:0060631)	2.22874704
97	synaptic transmission, cholinergic (GO:0007271)	2.22475552
98	DNA damage response, detection of DNA damage (GO:0042769)	2.22472047
99	tRNA processing (GO:0008033)	2.22194459
100	nucleoside diphosphate phosphorylation (GO:0006165)	2.21962813

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.42998823
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.42330165
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.14927500
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.09971356
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.02278428
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.95554087
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.94822650
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.85264088
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73159792
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.62638670
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.50711305
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.49944474
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44989930
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.44281969
15	EWS_26573619_Chip-Seq_HEK293_Human	2.32834751
16	FUS_26573619_Chip-Seq_HEK293_Human	2.24840102
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.23251311
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.17803448
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11215493
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06799616
21	P300_19829295_ChIP-Seq_ESCs_Human	2.04697229
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87522424
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.86598511
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.83231015
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.82724822
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.77979614
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.77952762
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.76495826
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71547553
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.65019038
31	VDR_23849224_ChIP-Seq_CD4+_Human	1.64592635
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.62630187
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53509663
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49870617
35	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.46225744
36	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.43535849
37	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.40950866
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40900581
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39975265
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.39042204
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38843162
42	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.38388669
43	AR_25329375_ChIP-Seq_VCAP_Human	1.36036721
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35260768
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35260768
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34839941
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33490249
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.33107225
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.32978587
50	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32412506
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32066101
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31521863
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31100640
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30176803
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29877555
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.27390780
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.25275316
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22279626
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22153074
60	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19284672
61	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17129433
62	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.16287514
63	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15648303
64	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.14353298
65	CBP_20019798_ChIP-Seq_JUKART_Human	1.12928356
66	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12928356
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12711359
68	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12711359
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12661417
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11928272
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11783207
72	RNF2_27304074_Chip-Seq_NSC_Mouse	1.09916728
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.09905465
74	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09905465
75	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.09548663
76	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.08429213
77	FOXP3_21729870_ChIP-Seq_TREG_Human	1.08363742
78	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08012180
79	NCOR_22424771_ChIP-Seq_293T_Human	1.07743490
80	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07546498
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06425401
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05929388
83	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.04488288
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04406047
85	TCF4_23295773_ChIP-Seq_U87_Human	1.04352809
86	AR_21572438_ChIP-Seq_LNCaP_Human	1.03312500
87	STAT3_23295773_ChIP-Seq_U87_Human	1.02025333
88	RUNX2_22187159_ChIP-Seq_PCA_Human	0.99324275
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.99074546
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98787619
91	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.98107286
92	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.97495468
93	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.96331686
94	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.95466223
95	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.95464268
96	HTT_18923047_ChIP-ChIP_STHdh_Human	0.94472459
97	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.94285124
98	AR_20517297_ChIP-Seq_VCAP_Human	0.93853411
99	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.93144552
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.92294803

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	3.85890297
2	MP0003136_yellow_coat_color	3.64098231
3	MP0003787_abnormal_imprinting	2.75867384
4	MP0008877_abnormal_DNA_methylation	2.69056833
5	MP0006292_abnormal_olfactory_placode	2.64204035
6	MP0000372_irregular_coat_pigmentation	2.53948631
7	MP0003195_calcinosis	2.49840109
8	MP0003121_genomic_imprinting	2.41982338
9	MP0003122_maternal_imprinting	2.40731566
10	MP0002102_abnormal_ear_morphology	2.28193730
11	MP0008058_abnormal_DNA_repair	2.26171040
12	MP0004142_abnormal_muscle_tone	2.23404939
13	MP0005645_abnormal_hypothalamus_physiol	2.17828614
14	MP0002638_abnormal_pupillary_reflex	2.04224766
15	MP0002938_white_spotting	2.03765301
16	MP0005551_abnormal_eye_electrophysiolog	1.99390342
17	MP0002653_abnormal_ependyma_morphology	1.95574923
18	MP0001984_abnormal_olfaction	1.94577357
19	MP0004885_abnormal_endolymph	1.89904995
20	MP0006072_abnormal_retinal_apoptosis	1.76314849
21	MP0001485_abnormal_pinna_reflex	1.69684114
22	MP0000569_abnormal_digit_pigmentation	1.67347594
23	MP0005646_abnormal_pituitary_gland	1.66227367
24	MP0002876_abnormal_thyroid_physiology	1.61918471
25	MP0001529_abnormal_vocalization	1.60894704
26	MP0009046_muscle_twitch	1.58910544
27	MP0002163_abnormal_gland_morphology	1.58264735
28	MP0001188_hyperpigmentation	1.57088925
29	MP0005379_endocrine/exocrine_gland_phen	1.56952256
30	MP0009745_abnormal_behavioral_response	1.56880873
31	MP0006276_abnormal_autonomic_nervous	1.56212267
32	MP0002272_abnormal_nervous_system	1.51970480
33	MP0001486_abnormal_startle_reflex	1.48737134
34	MP0001986_abnormal_taste_sensitivity	1.47045288
35	MP0008872_abnormal_physiological_respon	1.42949678
36	MP0005174_abnormal_tail_pigmentation	1.41745676
37	MP0000631_abnormal_neuroendocrine_gland	1.40175763
38	MP0003718_maternal_effect	1.37862306
39	MP0005253_abnormal_eye_physiology	1.36119433
40	MP0001968_abnormal_touch/_nociception	1.36028302
41	MP0002557_abnormal_social/conspecific_i	1.30378951
42	MP0005084_abnormal_gallbladder_morpholo	1.28130915
43	MP0008789_abnormal_olfactory_epithelium	1.27828721
44	MP0002909_abnormal_adrenal_gland	1.27331942
45	MP0002572_abnormal_emotion/affect_behav	1.26574826
46	MP0001970_abnormal_pain_threshold	1.25033665
47	MP0003880_abnormal_central_pattern	1.21791655
48	MP0002064_seizures	1.21676849
49	MP0002734_abnormal_mechanical_nocicepti	1.21437938
50	MP0002095_abnormal_skin_pigmentation	1.20414826
51	MP0002090_abnormal_vision	1.20263443
52	MP0009379_abnormal_foot_pigmentation	1.20252591
53	MP0001919_abnormal_reproductive_system	1.19951599
54	MP0002733_abnormal_thermal_nociception	1.18804385
55	MP0001501_abnormal_sleep_pattern	1.18524375
56	MP0003123_paternal_imprinting	1.18058733
57	MP0004145_abnormal_muscle_electrophysio	1.17214049
58	MP0008875_abnormal_xenobiotic_pharmacok	1.16574131
59	MP0005332_abnormal_amino_acid	1.15062510
60	MP0002736_abnormal_nociception_after	1.13483430
61	MP0005389_reproductive_system_phenotype	1.12445499
62	MP0004134_abnormal_chest_morphology	1.10308574
63	MP0004043_abnormal_pH_regulation	1.10034471
64	MP0009697_abnormal_copulation	1.09795214
65	MP0002751_abnormal_autonomic_nervous	1.09626767
66	MP0002160_abnormal_reproductive_system	1.07571060
67	MP0010386_abnormal_urinary_bladder	1.06954591
68	MP0002277_abnormal_respiratory_mucosa	1.02395262
69	MP0000778_abnormal_nervous_system	1.00528607
70	MP0001440_abnormal_grooming_behavior	0.99923527
71	MP0002735_abnormal_chemical_nociception	0.99687199
72	MP0003011_delayed_dark_adaptation	0.98250865
73	MP0002693_abnormal_pancreas_physiology	0.96161884
74	MP0000613_abnormal_salivary_gland	0.95928691
75	MP0005386_behavior/neurological_phenoty	0.95914850
76	MP0004924_abnormal_behavior	0.95914850
77	MP0003635_abnormal_synaptic_transmissio	0.95330932
78	MP0005195_abnormal_posterior_eye	0.94585030
79	MP0006035_abnormal_mitochondrial_morpho	0.93396551
80	MP0000427_abnormal_hair_cycle	0.90642283
81	MP0002063_abnormal_learning/memory/cond	0.90505672
82	MP0005187_abnormal_penis_morphology	0.90256004
83	MP0004215_abnormal_myocardial_fiber	0.89653995
84	MP0001944_abnormal_pancreas_morphology	0.88277818
85	MP0002184_abnormal_innervation	0.86693647
86	MP0002928_abnormal_bile_duct	0.85562543
87	MP0000955_abnormal_spinal_cord	0.85228439
88	MP0000015_abnormal_ear_pigmentation	0.84995718
89	MP0005423_abnormal_somatic_nervous	0.83936948
90	MP0005171_absent_coat_pigmentation	0.82226113
91	MP0001905_abnormal_dopamine_level	0.80759295
92	MP0005499_abnormal_olfactory_system	0.78947771
93	MP0005394_taste/olfaction_phenotype	0.78947771
94	MP0002067_abnormal_sensory_capabilities	0.76413501
95	MP0003119_abnormal_digestive_system	0.76317090
96	MP0004270_analgesia	0.76090300
97	MP0002229_neurodegeneration	0.75495664
98	MP0000371_diluted_coat_color	0.75053716
99	MP0002752_abnormal_somatic_nervous	0.73317085
100	MP0002138_abnormal_hepatobiliary_system	0.72737937

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.06205014
2	Progressive macrocephaly (HP:0004481)	3.78420444
3	Acute encephalopathy (HP:0006846)	3.67610676
4	Mitochondrial inheritance (HP:0001427)	3.58262439
5	Increased CSF lactate (HP:0002490)	3.53646672
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.37112526
7	True hermaphroditism (HP:0010459)	3.34396598
8	Abnormality of the labia minora (HP:0012880)	3.28473934
9	Nephronophthisis (HP:0000090)	3.22098228
10	Hypothermia (HP:0002045)	3.20705560
11	Pancreatic fibrosis (HP:0100732)	3.13625307
12	Abnormality of midbrain morphology (HP:0002418)	2.99320547
13	Molar tooth sign on MRI (HP:0002419)	2.99320547
14	Congenital stationary night blindness (HP:0007642)	2.93096464
15	Pancreatic cysts (HP:0001737)	2.89528715
16	Hepatocellular necrosis (HP:0001404)	2.80529705
17	Hyperventilation (HP:0002883)	2.78260602
18	Increased hepatocellular lipid droplets (HP:0006565)	2.77262202
19	Lipid accumulation in hepatocytes (HP:0006561)	2.74167437
20	Cerebral edema (HP:0002181)	2.66932060
21	Hepatic necrosis (HP:0002605)	2.63757653
22	Methylmalonic acidemia (HP:0002912)	2.54372023
23	Abnormality of the renal medulla (HP:0100957)	2.51959379
24	Optic disc pallor (HP:0000543)	2.50512649
25	Pendular nystagmus (HP:0012043)	2.49440262
26	Congenital, generalized hypertrichosis (HP:0004540)	2.48797261
27	Colon cancer (HP:0003003)	2.48410116
28	3-Methylglutaconic aciduria (HP:0003535)	2.38775894
29	Medial flaring of the eyebrow (HP:0010747)	2.34744160
30	Volvulus (HP:0002580)	2.33982493
31	Sclerocornea (HP:0000647)	2.31910334
32	Methylmalonic aciduria (HP:0012120)	2.30856306
33	Abnormality of vitamin B metabolism (HP:0004340)	2.24063190
34	Renal Fanconi syndrome (HP:0001994)	2.22431461
35	Chronic hepatic failure (HP:0100626)	2.18906336
36	Hyperinsulinemic hypoglycemia (HP:0000825)	2.18304727
37	Abnormality of the renal cortex (HP:0011035)	2.17868984
38	Exertional dyspnea (HP:0002875)	2.17206215
39	Increased serum lactate (HP:0002151)	2.11852232
40	Type II lissencephaly (HP:0007260)	2.09140331
41	Male pseudohermaphroditism (HP:0000037)	2.09018028
42	Glycosuria (HP:0003076)	2.08478203
43	Abnormality of urine glucose concentration (HP:0011016)	2.08478203
44	Hyperglycinemia (HP:0002154)	2.07797086
45	Neoplasm of the adrenal cortex (HP:0100641)	2.05836693
46	Hyperglycinuria (HP:0003108)	2.04312632
47	Respiratory failure (HP:0002878)	2.04195500
48	Lethargy (HP:0001254)	2.04036470
49	Abnormality of macular pigmentation (HP:0008002)	2.01263183
50	Median cleft lip (HP:0000161)	2.00225678
51	Abnormal rod and cone electroretinograms (HP:0008323)	2.00135298
52	Lactic acidosis (HP:0003128)	1.99868542
53	Neoplasm of the adrenal gland (HP:0100631)	1.97517246
54	Septo-optic dysplasia (HP:0100842)	1.97180155
55	Leukodystrophy (HP:0002415)	1.96232482
56	Hypoplasia of the fovea (HP:0007750)	1.94545882
57	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.94545882
58	Hyperphosphaturia (HP:0003109)	1.91958078
59	Lissencephaly (HP:0001339)	1.91508553
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.91487670
61	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.91487670
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89780891
63	Tubular atrophy (HP:0000092)	1.86644323
64	Gait imbalance (HP:0002141)	1.86340566
65	Large for gestational age (HP:0001520)	1.85698017
66	Abnormal hair whorl (HP:0010721)	1.85017569
67	Gaze-evoked nystagmus (HP:0000640)	1.84413356
68	Hypomagnesemia (HP:0002917)	1.83846026
69	Zonular cataract (HP:0010920)	1.80926020
70	Hypoglycemic coma (HP:0001325)	1.79805058
71	Abolished electroretinogram (ERG) (HP:0000550)	1.79704067
72	Abnormal drinking behavior (HP:0030082)	1.78868070
73	Polydipsia (HP:0001959)	1.78868070
74	Inability to walk (HP:0002540)	1.78476631
75	Short tibia (HP:0005736)	1.78210942
76	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77569937
77	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.76802136
78	Attenuation of retinal blood vessels (HP:0007843)	1.76780620
79	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.76654750
80	Cystic liver disease (HP:0006706)	1.76596076
81	Optic nerve hypoplasia (HP:0000609)	1.76075230
82	Epileptic encephalopathy (HP:0200134)	1.75842629
83	Ketosis (HP:0001946)	1.75593717
84	Pachygyria (HP:0001302)	1.75530256
85	Congenital primary aphakia (HP:0007707)	1.74281295
86	Furrowed tongue (HP:0000221)	1.73325926
87	Abnormality of glycine metabolism (HP:0010895)	1.73071545
88	Abnormality of serine family amino acid metabolism (HP:0010894)	1.73071545
89	X-linked dominant inheritance (HP:0001423)	1.71768696
90	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.71067757
91	Concave nail (HP:0001598)	1.70864137
92	Agitation (HP:0000713)	1.70657143
93	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.70480116
94	Polyphagia (HP:0002591)	1.68931379
95	Meckel diverticulum (HP:0002245)	1.68206886
96	Delayed CNS myelination (HP:0002188)	1.67890171
97	Hypochromic microcytic anemia (HP:0004840)	1.67587825
98	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.67436042
99	Focal motor seizures (HP:0011153)	1.67409012
100	Poor suck (HP:0002033)	1.66728044

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.31761884
2	PNCK	3.49668885
3	TRIM28	2.98209468
4	BMPR1B	2.89237279
5	TSSK6	2.70944745
6	WNK3	2.68862095
7	NUAK1	2.53963151
8	ACVR1B	2.41045215
9	MKNK2	2.35832106
10	VRK2	2.23512537
11	GRK1	2.23369210
12	ZAK	2.09033430
13	STK16	1.91937110
14	WEE1	1.89674088
15	CASK	1.88601906
16	EIF2AK1	1.85402471
17	MKNK1	1.84818392
18	TNIK	1.75544363
19	EIF2AK3	1.73760033
20	VRK1	1.72296153
21	MST4	1.65459870
22	TAF1	1.62489704
23	STK24	1.47415044
24	MAPK13	1.42284841
25	PLK3	1.40038918
26	PLK2	1.38632825
27	MAP3K4	1.37999802
28	NEK1	1.34053997
29	MAPK15	1.32009728
30	TLK1	1.29418003
31	ADRBK2	1.26177166
32	WNK4	1.23302935
33	DYRK2	1.21446269
34	PHKG2	1.15914236
35	PHKG1	1.15914236
36	PRKCG	1.09195155
37	ERBB3	1.08416291
38	MAPKAPK5	1.06079118
39	BUB1	1.05317153
40	CSNK1G2	1.05310983
41	CSNK1G1	1.03331915
42	MAPKAPK3	1.02694124
43	CSNK1A1L	1.01660755
44	MAP2K7	1.01518928
45	CSNK1G3	0.99829059
46	DYRK3	0.91880893
47	STK38L	0.91246723
48	NME1	0.90660497
49	MAP4K2	0.87459829
50	STK39	0.87108659
51	OXSR1	0.86522151
52	AKT3	0.84563700
53	CDC7	0.80671381
54	TGFBR1	0.79516042
55	BCKDK	0.77227314
56	PLK4	0.76073226
57	FGFR2	0.74127545
58	INSRR	0.74032035
59	TAOK3	0.73514711
60	PRKCE	0.72979035
61	STK3	0.72010775
62	BCR	0.71633337
63	PINK1	0.71268451
64	EPHA3	0.66515146
65	PBK	0.65035778
66	NLK	0.60149360
67	PAK3	0.59701712
68	PLK1	0.55536002
69	CAMK2A	0.52207366
70	TXK	0.51931025
71	GRK5	0.50777090
72	RPS6KA5	0.48710492
73	ADRBK1	0.48450383
74	CSNK1E	0.48237273
75	TIE1	0.47649163
76	MAP3K12	0.46398033
77	DYRK1A	0.46258344
78	EIF2AK2	0.45236438
79	CSNK1A1	0.44752013
80	PASK	0.44614720
81	ERBB2	0.43162591
82	PRKACA	0.42293616
83	MAP2K6	0.42267895
84	NTRK3	0.41540780
85	CCNB1	0.41403787
86	PRKG1	0.40380251
87	MARK1	0.39711536
88	CSNK2A2	0.38697125
89	PRKCI	0.38111376
90	ATM	0.37736385
91	ABL2	0.37375590
92	CSNK2A1	0.33577131
93	PRKACB	0.33156173
94	CAMK1	0.32989487
95	AURKA	0.32210552
96	CDK8	0.31899855
97	DAPK2	0.31081844
98	PDK2	0.30514539
99	CAMK1D	0.28540522
100	PKN1	0.27606245

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.76970145
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.42659042
3	Proteasome_Homo sapiens_hsa03050	2.93972769
4	Parkinsons disease_Homo sapiens_hsa05012	2.78069770
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.76752485
6	Propanoate metabolism_Homo sapiens_hsa00640	2.32694179
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.16395100
8	Butanoate metabolism_Homo sapiens_hsa00650	2.06403439
9	Alzheimers disease_Homo sapiens_hsa05010	1.86272359
10	Huntingtons disease_Homo sapiens_hsa05016	1.86114529
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.83232524
12	RNA polymerase_Homo sapiens_hsa03020	1.82958912
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.80448294
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.79368300
15	Basal transcription factors_Homo sapiens_hsa03022	1.75772468
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.74112268
17	Phototransduction_Homo sapiens_hsa04744	1.71920790
18	Ribosome_Homo sapiens_hsa03010	1.71670029
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.70377049
20	Homologous recombination_Homo sapiens_hsa03440	1.69476731
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.64082306
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.64044498
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.63106073
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59856187
25	One carbon pool by folate_Homo sapiens_hsa00670	1.59714743
26	Nicotine addiction_Homo sapiens_hsa05033	1.51523149
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.49516638
28	Sulfur metabolism_Homo sapiens_hsa00920	1.42954179
29	Peroxisome_Homo sapiens_hsa04146	1.42010702
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.39772339
31	RNA degradation_Homo sapiens_hsa03018	1.39337695
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.38944003
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.38091383
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.32358732
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.27099956
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19584603
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07581405
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.07556904
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06321306
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03459269
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.02870591
42	Insulin secretion_Homo sapiens_hsa04911	1.02762334
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99107416
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.98443157
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.96521454
46	Selenocompound metabolism_Homo sapiens_hsa00450	0.95997685
47	Retinol metabolism_Homo sapiens_hsa00830	0.95950098
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.95374532
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.94082970
50	Folate biosynthesis_Homo sapiens_hsa00790	0.94020909
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.92358244
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90779797
53	Fatty acid degradation_Homo sapiens_hsa00071	0.89921742
54	Mismatch repair_Homo sapiens_hsa03430	0.88437224
55	Purine metabolism_Homo sapiens_hsa00230	0.85259839
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83213776
57	Spliceosome_Homo sapiens_hsa03040	0.82079559
58	RNA transport_Homo sapiens_hsa03013	0.81697953
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78421045
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76826222
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.76624445
62	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.76499862
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.75938912
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.75414592
65	Metabolic pathways_Homo sapiens_hsa01100	0.74620424
66	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.73633468
67	Non-homologous end-joining_Homo sapiens_hsa03450	0.73112106
68	Morphine addiction_Homo sapiens_hsa05032	0.70266706
69	Olfactory transduction_Homo sapiens_hsa04740	0.69641163
70	Taste transduction_Homo sapiens_hsa04742	0.69477677
71	Pyrimidine metabolism_Homo sapiens_hsa00240	0.68826072
72	GABAergic synapse_Homo sapiens_hsa04727	0.67729030
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.66853541
74	Fatty acid elongation_Homo sapiens_hsa00062	0.65407062
75	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.64920288
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.64369758
77	Type I diabetes mellitus_Homo sapiens_hsa04940	0.60644278
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.59654597
79	Caffeine metabolism_Homo sapiens_hsa00232	0.56020134
80	Serotonergic synapse_Homo sapiens_hsa04726	0.54811877
81	Glutathione metabolism_Homo sapiens_hsa00480	0.54078818
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51966760
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51815957
84	Regulation of autophagy_Homo sapiens_hsa04140	0.47081348
85	Mineral absorption_Homo sapiens_hsa04978	0.46836513
86	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.43917160
87	Arginine biosynthesis_Homo sapiens_hsa00220	0.42965688
88	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.41964213
89	DNA replication_Homo sapiens_hsa03030	0.41653153
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.41227270
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.39897763
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37043140
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.36874026
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36765828
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.35713784
96	Amphetamine addiction_Homo sapiens_hsa05031	0.34763132
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.34347613
98	Asthma_Homo sapiens_hsa05310	0.33068579
99	Circadian entrainment_Homo sapiens_hsa04713	0.32345970
100	Cocaine addiction_Homo sapiens_hsa05030	0.31486503

HSP90AA5P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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