ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.87322301
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.28890276
3	protein neddylation (GO:0045116)	4.20725246
4	ATP synthesis coupled proton transport (GO:0015986)	4.11744966
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.11744966
6	DNA double-strand break processing (GO:0000729)	4.06792941
7	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.97738569
8	proteasome assembly (GO:0043248)	3.97109587
9	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.92443377
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.92443377
11	NADH dehydrogenase complex assembly (GO:0010257)	3.92443377
12	chromatin remodeling at centromere (GO:0031055)	3.88345645
13	water-soluble vitamin biosynthetic process (GO:0042364)	3.87566789
14	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.83533824
15	cullin deneddylation (GO:0010388)	3.78826453
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.76000854
17	rRNA modification (GO:0000154)	3.74689061
18	CENP-A containing nucleosome assembly (GO:0034080)	3.73115422
19	protein complex biogenesis (GO:0070271)	3.69459027
20	mitochondrial respiratory chain complex assembly (GO:0033108)	3.61978017
21	replication fork processing (GO:0031297)	3.59333457
22	DNA replication checkpoint (GO:0000076)	3.53226008
23	protein deneddylation (GO:0000338)	3.51490429
24	DNA damage response, detection of DNA damage (GO:0042769)	3.50083088
25	rRNA methylation (GO:0031167)	3.45966119
26	IMP biosynthetic process (GO:0006188)	3.34230872
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.31704237
28	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.30227549
29	maturation of 5.8S rRNA (GO:0000460)	3.28955485
30	DNA deamination (GO:0045006)	3.28501674
31	histone exchange (GO:0043486)	3.28418713
32	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.28293623
33	protein-cofactor linkage (GO:0018065)	3.24292818
34	behavioral response to nicotine (GO:0035095)	3.23951513
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.23103069
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.23103069
37	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.19041145
38	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.19041145
39	isotype switching (GO:0045190)	3.19041145
40	chaperone-mediated protein transport (GO:0072321)	3.18864981
41	pseudouridine synthesis (GO:0001522)	3.15929721
42	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.13541802
43	negative regulation of DNA recombination (GO:0045910)	3.12499244
44	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.12376740
45	termination of RNA polymerase III transcription (GO:0006386)	3.12376740
46	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.11078835
47	regulation of cellular amino acid metabolic process (GO:0006521)	3.03168430
48	DNA catabolic process, exonucleolytic (GO:0000738)	3.00582734
49	negative regulation of telomere maintenance (GO:0032205)	2.97992957
50	L-fucose catabolic process (GO:0042355)	2.97336022
51	fucose catabolic process (GO:0019317)	2.97336022
52	L-fucose metabolic process (GO:0042354)	2.97336022
53	respiratory chain complex IV assembly (GO:0008535)	2.96579796
54	resolution of meiotic recombination intermediates (GO:0000712)	2.95795723
55	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.95719012
56	regulation of mitotic spindle checkpoint (GO:1903504)	2.95719012
57	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.95119459
58	histone mRNA metabolic process (GO:0008334)	2.93951205
59	negative regulation of ligase activity (GO:0051352)	2.93078893
60	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.93078893
61	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.88425205
62	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.87883310
63	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.87883310
64	tRNA processing (GO:0008033)	2.87237104
65	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.86618017
66	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.86618017
67	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.86618017
68	pteridine-containing compound biosynthetic process (GO:0042559)	2.85760040
69	tRNA metabolic process (GO:0006399)	2.83882464
70	ribosome assembly (GO:0042255)	2.83422449
71	inner mitochondrial membrane organization (GO:0007007)	2.82361201
72	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.82090038
73	protein K6-linked ubiquitination (GO:0085020)	2.79258926
74	respiratory electron transport chain (GO:0022904)	2.78934847
75	postreplication repair (GO:0006301)	2.78637755
76	electron transport chain (GO:0022900)	2.77883988
77	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.76108976
78	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.75724849
79	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.75724849
80	purine nucleobase biosynthetic process (GO:0009113)	2.75697763
81	IMP metabolic process (GO:0046040)	2.75222394
82	regulation of helicase activity (GO:0051095)	2.74194698
83	DNA replication-dependent nucleosome assembly (GO:0006335)	2.74109360
84	DNA replication-dependent nucleosome organization (GO:0034723)	2.74109360
85	nucleobase biosynthetic process (GO:0046112)	2.74063174
86	organelle disassembly (GO:1903008)	2.73497283
87	amino acid activation (GO:0043038)	2.71564631
88	tRNA aminoacylation (GO:0043039)	2.71564631
89	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.71551973
90	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.71551973
91	folic acid-containing compound biosynthetic process (GO:0009396)	2.71384174
92	mannosylation (GO:0097502)	2.71139677
93	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.70216729
94	DNA replication-independent nucleosome organization (GO:0034724)	2.70167749
95	DNA replication-independent nucleosome assembly (GO:0006336)	2.70167749
96	viral mRNA export from host cell nucleus (GO:0046784)	2.68979061
97	rRNA processing (GO:0006364)	2.65193683
98	tRNA aminoacylation for protein translation (GO:0006418)	2.64280651
99	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.63298737
100	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.62677028

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.30862082
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.83035632
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.80855096
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.49381958
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.91907733
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.84263395
7	E2F7_22180533_ChIP-Seq_HELA_Human	2.76542180
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.61853667
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.53101841
10	VDR_22108803_ChIP-Seq_LS180_Human	2.50486573
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.50038544
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.42094357
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.40269041
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.33955197
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30976679
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.24705710
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.23459542
18	EWS_26573619_Chip-Seq_HEK293_Human	2.23405704
19	VDR_23849224_ChIP-Seq_CD4+_Human	2.20138687
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.19058271
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.13163952
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.03634429
23	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.01658719
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.96404092
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.92095888
26	FUS_26573619_Chip-Seq_HEK293_Human	1.90796084
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.89297763
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.87712905
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.86174049
30	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.82106516
31	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.81199404
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80004384
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.79445719
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.73424387
35	P300_19829295_ChIP-Seq_ESCs_Human	1.69880952
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.67357852
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.57287575
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56330313
39	GBX2_23144817_ChIP-Seq_PC3_Human	1.50833981
40	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.48621070
41	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.48494797
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.47408591
43	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.46857236
44	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45776068
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.40845827
46	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.40784320
47	DCP1A_22483619_ChIP-Seq_HELA_Human	1.36680452
48	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.36672235
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35940080
50	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.35510416
51	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31240254
52	GABP_19822575_ChIP-Seq_HepG2_Human	1.28394786
53	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28002526
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.26108879
55	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.25870142
56	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.25558190
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22889488
58	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.22172676
59	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.21032251
60	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.18478194
61	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.17806984
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17125234
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.17116601
64	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.16145622
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15817295
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15076108
67	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.13110645
68	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10714441
69	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.10317448
70	ER_23166858_ChIP-Seq_MCF-7_Human	1.08806547
71	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.08801224
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07512869
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06851397
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05558625
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.05558625
76	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.05472437
77	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.03118898
78	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.02101549
79	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.01896131
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01138765
81	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.00252959
82	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.99647270
83	XRN2_22483619_ChIP-Seq_HELA_Human	0.98351662
84	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.98004721
85	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97754088
86	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97754088
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96715479
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96473728
89	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.96315251
90	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.96182751
91	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.95162019
92	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.94454817
93	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.93061147
94	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92639582
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.92639582
96	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.92537824
97	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90707415
98	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.90434758
99	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.90040106
100	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.89333508

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003890_abnormal_embryonic-extraembry	3.34714376
2	MP0008058_abnormal_DNA_repair	3.19798059
3	MP0002102_abnormal_ear_morphology	3.12641960
4	MP0008877_abnormal_DNA_methylation	2.83613293
5	MP0003693_abnormal_embryo_hatching	2.47751780
6	MP0001529_abnormal_vocalization	2.44980881
7	MP0010094_abnormal_chromosome_stability	2.38113091
8	MP0006072_abnormal_retinal_apoptosis	2.35955589
9	MP0001188_hyperpigmentation	2.10821034
10	MP0002938_white_spotting	2.10160304
11	MP0004957_abnormal_blastocyst_morpholog	1.97476872
12	MP0003122_maternal_imprinting	1.97457158
13	MP0006292_abnormal_olfactory_placode	1.96088905
14	MP0002736_abnormal_nociception_after	1.94828474
15	MP0003880_abnormal_central_pattern	1.94150856
16	MP0003121_genomic_imprinting	1.91361124
17	MP0003787_abnormal_imprinting	1.86126528
18	MP0004885_abnormal_endolymph	1.86113176
19	MP0003195_calcinosis	1.81750669
20	MP0005084_abnormal_gallbladder_morpholo	1.77488646
21	MP0002254_reproductive_system_inflammat	1.75614309
22	MP0004133_heterotaxia	1.75067997
23	MP0008057_abnormal_DNA_replication	1.70806788
24	MP0005645_abnormal_hypothalamus_physiol	1.69112525
25	MP0001293_anophthalmia	1.63219857
26	MP0001984_abnormal_olfaction	1.57663950
27	MP0001968_abnormal_touch/_nociception	1.57294645
28	MP0003119_abnormal_digestive_system	1.57001881
29	MP0004142_abnormal_muscle_tone	1.55671783
30	MP0005551_abnormal_eye_electrophysiolog	1.54584427
31	MP0006035_abnormal_mitochondrial_morpho	1.54224655
32	MP0002837_dystrophic_cardiac_calcinosis	1.52476707
33	MP0008872_abnormal_physiological_respon	1.47825195
34	MP0003718_maternal_effect	1.47183509
35	MP0003937_abnormal_limbs/digits/tail_de	1.42606751
36	MP0003786_premature_aging	1.42468782
37	MP0006276_abnormal_autonomic_nervous	1.40046625
38	MP0008932_abnormal_embryonic_tissue	1.39505154
39	MP0000372_irregular_coat_pigmentation	1.37827534
40	MP0003111_abnormal_nucleus_morphology	1.37058847
41	MP0008007_abnormal_cellular_replicative	1.35806915
42	MP0003567_abnormal_fetal_cardiomyocyte	1.35737716
43	MP0002272_abnormal_nervous_system	1.33810570
44	MP0005253_abnormal_eye_physiology	1.33522634
45	MP0002751_abnormal_autonomic_nervous	1.31357227
46	MP0003011_delayed_dark_adaptation	1.27663435
47	MP0003186_abnormal_redox_activity	1.26963323
48	MP0002184_abnormal_innervation	1.26676406
49	MP0000569_abnormal_digit_pigmentation	1.24608608
50	MP0003077_abnormal_cell_cycle	1.20445514
51	MP0002277_abnormal_respiratory_mucosa	1.18139985
52	MP0001485_abnormal_pinna_reflex	1.16186654
53	MP0000631_abnormal_neuroendocrine_gland	1.08934241
54	MP0009745_abnormal_behavioral_response	1.08328583
55	MP0008875_abnormal_xenobiotic_pharmacok	1.07399824
56	MP0001486_abnormal_startle_reflex	1.06638087
57	MP0001905_abnormal_dopamine_level	1.05461350
58	MP0009697_abnormal_copulation	1.04761011
59	MP0006036_abnormal_mitochondrial_physio	1.03660940
60	MP0002163_abnormal_gland_morphology	1.03303085
61	MP0001986_abnormal_taste_sensitivity	1.02868936
62	MP0000778_abnormal_nervous_system	1.01507186
63	MP0004742_abnormal_vestibular_system	0.99858481
64	MP0002734_abnormal_mechanical_nocicepti	0.99667712
65	MP0003806_abnormal_nucleotide_metabolis	0.98971837
66	MP0005423_abnormal_somatic_nervous	0.97481582
67	MP0004147_increased_porphyrin_level	0.96564966
68	MP0002210_abnormal_sex_determination	0.96059573
69	MP0008995_early_reproductive_senescence	0.93767276
70	MP0002160_abnormal_reproductive_system	0.93746028
71	MP0002572_abnormal_emotion/affect_behav	0.93574614
72	MP0002557_abnormal_social/conspecific_i	0.93470474
73	MP0008789_abnormal_olfactory_epithelium	0.93340041
74	MP0002067_abnormal_sensory_capabilities	0.92500705
75	MP0004215_abnormal_myocardial_fiber	0.91258083
76	MP0005394_taste/olfaction_phenotype	0.90792137
77	MP0005499_abnormal_olfactory_system	0.90792137
78	MP0000955_abnormal_spinal_cord	0.90255645
79	MP0002876_abnormal_thyroid_physiology	0.89209553
80	MP0001929_abnormal_gametogenesis	0.87141849
81	MP0002735_abnormal_chemical_nociception	0.85123002
82	MP0001286_abnormal_eye_development	0.85094868
83	MP0001873_stomach_inflammation	0.84617241
84	MP0002752_abnormal_somatic_nervous	0.84301642
85	MP0000516_abnormal_urinary_system	0.81032735
86	MP0005367_renal/urinary_system_phenotyp	0.81032735
87	MP0004145_abnormal_muscle_electrophysio	0.80912262
88	MP0002234_abnormal_pharynx_morphology	0.80810319
89	MP0001440_abnormal_grooming_behavior	0.78848280
90	MP0005379_endocrine/exocrine_gland_phen	0.78539608
91	MP0000653_abnormal_sex_gland	0.77141341
92	MP0002090_abnormal_vision	0.76431870
93	MP0009046_muscle_twitch	0.75093851
94	MP0003941_abnormal_skin_development	0.74283454
95	MP0000427_abnormal_hair_cycle	0.74089019
96	MP0001970_abnormal_pain_threshold	0.74029835
97	MP0002084_abnormal_developmental_patter	0.73975812
98	MP0000358_abnormal_cell_content/	0.71054665
99	MP0005389_reproductive_system_phenotype	0.70938355
100	MP0001145_abnormal_male_reproductive	0.70756945

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.94137091
2	Acute encephalopathy (HP:0006846)	3.78173096
3	Abnormality of the labia minora (HP:0012880)	3.60162875
4	Increased hepatocellular lipid droplets (HP:0006565)	3.48344825
5	Increased CSF lactate (HP:0002490)	3.42777820
6	Methylmalonic acidemia (HP:0002912)	3.34707940
7	Progressive macrocephaly (HP:0004481)	3.28330865
8	Mitochondrial inheritance (HP:0001427)	3.25435635
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.25379324
10	Lipid accumulation in hepatocytes (HP:0006561)	3.13788416
11	Colon cancer (HP:0003003)	2.85456254
12	Abnormality of midbrain morphology (HP:0002418)	2.77948383
13	Molar tooth sign on MRI (HP:0002419)	2.77948383
14	Renal cortical cysts (HP:0000803)	2.70918167
15	3-Methylglutaconic aciduria (HP:0003535)	2.57883804
16	Cerebral edema (HP:0002181)	2.54495275
17	Pancreatic cysts (HP:0001737)	2.54214586
18	Hepatocellular necrosis (HP:0001404)	2.49934784
19	Congenital, generalized hypertrichosis (HP:0004540)	2.48086417
20	Volvulus (HP:0002580)	2.43966253
21	Nephronophthisis (HP:0000090)	2.41053973
22	Increased serum lactate (HP:0002151)	2.41002513
23	Hepatic necrosis (HP:0002605)	2.40334242
24	Methylmalonic aciduria (HP:0012120)	2.39580062
25	Abnormality of the renal cortex (HP:0011035)	2.39057170
26	Abnormality of alanine metabolism (HP:0010916)	2.38424139
27	Hyperalaninemia (HP:0003348)	2.38424139
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.38424139
29	Type II lissencephaly (HP:0007260)	2.37289700
30	Renal Fanconi syndrome (HP:0001994)	2.34227730
31	Progressive inability to walk (HP:0002505)	2.33857579
32	Hyperglycinemia (HP:0002154)	2.31950574
33	Hypothermia (HP:0002045)	2.30545568
34	Abnormality of the pons (HP:0007361)	2.26784286
35	Pendular nystagmus (HP:0012043)	2.26003351
36	Optic disc pallor (HP:0000543)	2.24773546
37	Medial flaring of the eyebrow (HP:0010747)	2.22097516
38	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20516979
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.16037777
40	Hypoplasia of the pons (HP:0012110)	2.15698762
41	Limb dystonia (HP:0002451)	2.15529352
42	Pancreatic fibrosis (HP:0100732)	2.13421699
43	Abnormality of serum amino acid levels (HP:0003112)	2.12907188
44	Meckel diverticulum (HP:0002245)	2.12558482
45	Abolished electroretinogram (ERG) (HP:0000550)	2.12287690
46	Congenital stationary night blindness (HP:0007642)	2.07768320
47	True hermaphroditism (HP:0010459)	2.06018748
48	Inability to walk (HP:0002540)	2.05032744
49	Abnormality of the ileum (HP:0001549)	2.04442619
50	Lactic acidosis (HP:0003128)	2.04108662
51	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.03968072
52	Abnormality of the renal medulla (HP:0100957)	2.01088312
53	Poor suck (HP:0002033)	1.98942045
54	Lissencephaly (HP:0001339)	1.96738820
55	Leukodystrophy (HP:0002415)	1.96268394
56	Abnormality of vitamin B metabolism (HP:0004340)	1.95870442
57	Abnormality of methionine metabolism (HP:0010901)	1.93580765
58	Lethargy (HP:0001254)	1.92381698
59	Abnormal lung lobation (HP:0002101)	1.91929983
60	Exertional dyspnea (HP:0002875)	1.91599899
61	Abnormality of glycine metabolism (HP:0010895)	1.91547787
62	Abnormality of serine family amino acid metabolism (HP:0010894)	1.91547787
63	Abnormality of chromosome stability (HP:0003220)	1.88134858
64	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.87892300
65	Aplasia/hypoplasia of the uterus (HP:0008684)	1.87182903
66	Gait imbalance (HP:0002141)	1.87044488
67	Abnormal hair whorl (HP:0010721)	1.85919211
68	Large for gestational age (HP:0001520)	1.83524749
69	Hyperglycinuria (HP:0003108)	1.80910470
70	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.78818096
71	Neoplasm of the adrenal gland (HP:0100631)	1.78754969
72	Type I transferrin isoform profile (HP:0003642)	1.78723348
73	Glycosuria (HP:0003076)	1.76583999
74	Abnormality of urine glucose concentration (HP:0011016)	1.76583999
75	Limb hypertonia (HP:0002509)	1.75002887
76	Increased serum pyruvate (HP:0003542)	1.74299136
77	Gonadotropin excess (HP:0000837)	1.74057411
78	Septo-optic dysplasia (HP:0100842)	1.73822714
79	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.73746669
80	Chromsome breakage (HP:0040012)	1.73304006
81	Exercise intolerance (HP:0003546)	1.73109870
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.72715475
83	Nephrogenic diabetes insipidus (HP:0009806)	1.70691777
84	Congenital primary aphakia (HP:0007707)	1.70541896
85	Small hand (HP:0200055)	1.70424981
86	Ependymoma (HP:0002888)	1.67776914
87	Retinal dysplasia (HP:0007973)	1.66468707
88	Adrenal hypoplasia (HP:0000835)	1.65751991
89	Abnormality of renal resorption (HP:0011038)	1.65732265
90	Pancreatic islet-cell hyperplasia (HP:0004510)	1.63792031
91	Abnormality of the preputium (HP:0100587)	1.63373771
92	Generalized aminoaciduria (HP:0002909)	1.63275071
93	Respiratory failure (HP:0002878)	1.62493059
94	Hyperinsulinemic hypoglycemia (HP:0000825)	1.62289081
95	Cortical dysplasia (HP:0002539)	1.62257704
96	Pancytopenia (HP:0001876)	1.62035776
97	Reduced antithrombin III activity (HP:0001976)	1.61832630
98	Polyphagia (HP:0002591)	1.61180766
99	Abnormal glycosylation (HP:0012345)	1.60647154
100	Abnormal protein N-linked glycosylation (HP:0012347)	1.60647154

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	4.60189846
2	ZAK	3.12228032
3	TRIM28	3.10732717
4	PNCK	2.71547883
5	WNK3	2.55804280
6	MST4	2.53526694
7	MKNK2	2.44669416
8	NUAK1	2.34103981
9	BUB1	2.32555049
10	PLK3	2.22666740
11	MAP3K12	2.15976093
12	BMPR1B	2.10918428
13	EIF2AK3	2.10547441
14	VRK2	2.05197610
15	BCR	1.96362904
16	NEK1	1.96059845
17	SRPK1	1.88198862
18	TNIK	1.87975334
19	MKNK1	1.83208716
20	EIF2AK1	1.79446494
21	TAF1	1.73513894
22	WEE1	1.65702788
23	DYRK2	1.64604761
24	TXK	1.59446903
25	NME1	1.59263265
26	TLK1	1.57801323
27	VRK1	1.55627278
28	TTK	1.55456296
29	PBK	1.54213961
30	ADRBK2	1.50829055
31	PLK4	1.49854244
32	CDC7	1.49393116
33	GRK1	1.40085486
34	FRK	1.31146219
35	MARK1	1.18050533
36	MAP3K4	1.17460298
37	CSNK1G2	1.17186396
38	MAP4K2	1.16434380
39	CASK	1.15675477
40	WNK4	1.15381593
41	CSNK1G1	1.09767260
42	CSNK1G3	1.06599883
43	EIF2AK2	1.06503803
44	MAPK13	1.04648010
45	PLK2	1.04236359
46	PLK1	1.03794079
47	ACVR1B	1.02398786
48	CSNK1A1L	0.98833271
49	ERBB3	0.97376224
50	OXSR1	0.95221377
51	PINK1	0.91932224
52	MINK1	0.91025202
53	STK39	0.88945484
54	INSRR	0.87960910
55	PASK	0.85210791
56	ALK	0.79851456
57	PHKG1	0.77181712
58	PHKG2	0.77181712
59	STK16	0.76372644
60	PRKCG	0.75768079
61	CHEK2	0.74098654
62	MAP2K7	0.74034179
63	ATR	0.71531292
64	PRKCE	0.66065484
65	TGFBR1	0.59764102
66	ATM	0.58020197
67	CSNK1E	0.57309018
68	TIE1	0.56976525
69	ADRBK1	0.54884072
70	BRSK2	0.54645865
71	RPS6KA4	0.53513921
72	SIK3	0.51839134
73	BCKDK	0.51337769
74	DAPK1	0.48375301
75	MAP2K6	0.47495827
76	CSNK2A2	0.45381074
77	CSNK2A1	0.43066306
78	PAK3	0.42228840
79	ERBB4	0.42184989
80	AURKB	0.42142319
81	CSNK1A1	0.41903186
82	MAP2K4	0.41018726
83	FGFR1	0.40307042
84	MAPKAPK5	0.37940497
85	CDK3	0.36760391
86	PRKCI	0.36406533
87	GRK7	0.34561661
88	STK3	0.33646311
89	CAMK2A	0.31091690
90	CHEK1	0.31062355
91	PRKDC	0.30274579
92	FER	0.30084817
93	NEK2	0.29155364
94	DAPK2	0.27972516
95	DYRK3	0.26979954
96	FLT3	0.26392195
97	NLK	0.26267482
98	PDK2	0.25762274
99	PRKACA	0.23937287
100	RPS6KA5	0.23795910

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.33734272
2	Protein export_Homo sapiens_hsa03060	3.73664603
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.02148527
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.98305536
5	Parkinsons disease_Homo sapiens_hsa05012	2.56728621
6	Mismatch repair_Homo sapiens_hsa03430	2.36307395
7	RNA polymerase_Homo sapiens_hsa03020	2.31839327
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.23536420
9	RNA degradation_Homo sapiens_hsa03018	2.21601399
10	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.11535998
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.08600299
12	Basal transcription factors_Homo sapiens_hsa03022	2.06811829
13	Propanoate metabolism_Homo sapiens_hsa00640	2.06155286
14	RNA transport_Homo sapiens_hsa03013	1.89338794
15	One carbon pool by folate_Homo sapiens_hsa00670	1.89082897
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.84632128
17	Homologous recombination_Homo sapiens_hsa03440	1.80350770
18	Spliceosome_Homo sapiens_hsa03040	1.79478660
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.79320941
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.76222393
21	DNA replication_Homo sapiens_hsa03030	1.73301474
22	Huntingtons disease_Homo sapiens_hsa05016	1.72578765
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65393394
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.58856851
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.58177354
26	Phototransduction_Homo sapiens_hsa04744	1.53825520
27	Alzheimers disease_Homo sapiens_hsa05010	1.53271444
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.52401068
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.51879676
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.42063887
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.41447951
32	Ribosome_Homo sapiens_hsa03010	1.32077220
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.25984276
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.24298871
35	Folate biosynthesis_Homo sapiens_hsa00790	1.21951377
36	Nicotine addiction_Homo sapiens_hsa05033	1.19926333
37	Butanoate metabolism_Homo sapiens_hsa00650	1.17668958
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.15694578
39	Purine metabolism_Homo sapiens_hsa00230	1.15009560
40	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.13656585
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.11580154
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.10356892
43	Sulfur metabolism_Homo sapiens_hsa00920	1.06592715
44	Caffeine metabolism_Homo sapiens_hsa00232	1.03993917
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.03792494
46	Base excision repair_Homo sapiens_hsa03410	0.99995220
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.94813797
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.93516624
49	Fatty acid elongation_Homo sapiens_hsa00062	0.93196377
50	Cell cycle_Homo sapiens_hsa04110	0.82505335
51	Regulation of autophagy_Homo sapiens_hsa04140	0.81542468
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.80811741
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.80106201
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.79573476
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72744300
56	Peroxisome_Homo sapiens_hsa04146	0.71837030
57	Metabolic pathways_Homo sapiens_hsa01100	0.71793547
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70584139
59	Linoleic acid metabolism_Homo sapiens_hsa00591	0.69133956
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67114115
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64566555
62	GABAergic synapse_Homo sapiens_hsa04727	0.61946058
63	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.60572906
64	Oocyte meiosis_Homo sapiens_hsa04114	0.56678884
65	Taste transduction_Homo sapiens_hsa04742	0.55738501
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55384834
67	Glutathione metabolism_Homo sapiens_hsa00480	0.55138798
68	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.53148481
69	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.52410628
70	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.51886534
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.51574795
72	p53 signaling pathway_Homo sapiens_hsa04115	0.51303199
73	Morphine addiction_Homo sapiens_hsa05032	0.48660889
74	Olfactory transduction_Homo sapiens_hsa04740	0.46705140
75	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.46652892
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.45452151
77	Sulfur relay system_Homo sapiens_hsa04122	0.44501764
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44307646
79	Nitrogen metabolism_Homo sapiens_hsa00910	0.43607414
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.42245763
81	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40378462
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39789617
83	Retinol metabolism_Homo sapiens_hsa00830	0.37762057
84	Wnt signaling pathway_Homo sapiens_hsa04310	0.37472529
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.35540411
86	Serotonergic synapse_Homo sapiens_hsa04726	0.35202356
87	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34667409
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.32735350
89	Carbon metabolism_Homo sapiens_hsa01200	0.32701414
90	Fatty acid degradation_Homo sapiens_hsa00071	0.31631360
91	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.31502878
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31490575
93	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.31039120
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.30135744
95	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.29863151
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.29800572
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.27351596
98	Basal cell carcinoma_Homo sapiens_hsa05217	0.25205103
99	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.24426434
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.23933704

HSP90AA6P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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