HSP90AB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.23531578
2nucleobase biosynthetic process (GO:0046112)4.75527954
3maturation of SSU-rRNA (GO:0030490)4.60202175
4nuclear pore organization (GO:0006999)4.57009823
5ribosome assembly (GO:0042255)4.45168624
6formation of translation preinitiation complex (GO:0001731)4.42758702
7IMP biosynthetic process (GO:0006188)4.39669971
8nuclear pore complex assembly (GO:0051292)4.30644778
9purine nucleobase biosynthetic process (GO:0009113)4.26977902
10DNA replication initiation (GO:0006270)4.26685261
11protein localization to kinetochore (GO:0034501)4.24617814
12mitotic nuclear envelope disassembly (GO:0007077)4.14555885
13establishment of viral latency (GO:0019043)4.11844687
14DNA strand elongation involved in DNA replication (GO:0006271)4.10515342
15folic acid-containing compound biosynthetic process (GO:0009396)4.02269076
16membrane disassembly (GO:0030397)3.89648977
17nuclear envelope disassembly (GO:0051081)3.89648977
18DNA strand elongation (GO:0022616)3.88554980
19ribosomal small subunit assembly (GO:0000028)3.88501016
20double-strand break repair via nonhomologous end joining (GO:0006303)3.85941288
21non-recombinational repair (GO:0000726)3.85941288
22ribosome biogenesis (GO:0042254)3.82231918
23IMP metabolic process (GO:0046040)3.81619873
24protein complex localization (GO:0031503)3.81468076
25pre-miRNA processing (GO:0031054)3.79928065
26peptidyl-arginine omega-N-methylation (GO:0035247)3.74308786
27mitotic metaphase plate congression (GO:0007080)3.74139954
28regulation of translational termination (GO:0006449)3.70201626
29DNA replication-dependent nucleosome organization (GO:0034723)3.66250623
30DNA replication-dependent nucleosome assembly (GO:0006335)3.66250623
31tRNA aminoacylation for protein translation (GO:0006418)3.66167634
32tRNA aminoacylation (GO:0043039)3.60096782
33amino acid activation (GO:0043038)3.60096782
34ribonucleoprotein complex biogenesis (GO:0022613)3.57599058
35ribosomal large subunit biogenesis (GO:0042273)3.56478611
36negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.54428933
37DNA duplex unwinding (GO:0032508)3.52920971
38DNA replication checkpoint (GO:0000076)3.52218427
39DNA geometric change (GO:0032392)3.51540576
40mitotic sister chromatid segregation (GO:0000070)3.47640976
41DNA ligation (GO:0006266)3.47315161
42regulation of gene silencing by RNA (GO:0060966)3.45697237
43regulation of posttranscriptional gene silencing (GO:0060147)3.45697237
44regulation of gene silencing by miRNA (GO:0060964)3.45697237
45regulation of spindle organization (GO:0090224)3.43976300
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.43623060
47telomere maintenance via semi-conservative replication (GO:0032201)3.41479705
48L-serine metabolic process (GO:0006563)3.40506634
49translational initiation (GO:0006413)3.39146796
50positive regulation of chromosome segregation (GO:0051984)3.39001428
51protein localization to chromosome, centromeric region (GO:0071459)3.37172268
52translational termination (GO:0006415)3.36497725
53histone arginine methylation (GO:0034969)3.36302936
54viral transcription (GO:0019083)3.35427931
55proteasome assembly (GO:0043248)3.34771690
56sister chromatid segregation (GO:0000819)3.33364493
57peptidyl-arginine N-methylation (GO:0035246)3.31665775
58peptidyl-arginine methylation (GO:0018216)3.31665775
59metaphase plate congression (GO:0051310)3.31441784
60pore complex assembly (GO:0046931)3.31430947
61regulation of translational fidelity (GO:0006450)3.26845893
62spliceosomal snRNP assembly (GO:0000387)3.25340794
63rRNA processing (GO:0006364)3.25153649
64mRNA splicing, via spliceosome (GO:0000398)3.24016385
65RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.24016385
66RNA splicing, via transesterification reactions (GO:0000375)3.23458914
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22961530
68negative regulation of histone methylation (GO:0031061)3.22301381
69regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21795369
70translational elongation (GO:0006414)3.20644031
71negative regulation of RNA splicing (GO:0033119)3.20380089
72establishment of integrated proviral latency (GO:0075713)3.18878007
73maturation of 5.8S rRNA (GO:0000460)3.16422903
74histone exchange (GO:0043486)3.15618627
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15391557
76rRNA metabolic process (GO:0016072)3.15235779
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15112546
78ribosomal small subunit biogenesis (GO:0042274)3.14469098
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14386497
80somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13037579
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.13037579
82mitotic sister chromatid cohesion (GO:0007064)3.11808463
83heterochromatin organization (GO:0070828)3.11100043
84cellular protein complex localization (GO:0034629)3.08997000
85mitotic recombination (GO:0006312)3.08250550
86regulation of centrosome cycle (GO:0046605)3.05603282
87telomere maintenance via recombination (GO:0000722)3.05446174
88telomere maintenance via telomere lengthening (GO:0010833)3.05143370
89regulation of helicase activity (GO:0051095)3.04311206
90negative regulation of mRNA processing (GO:0050686)3.03754456
91nuclear envelope organization (GO:0006998)3.03264238
92regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02362579
93regulation of mitotic spindle organization (GO:0060236)3.01738457
94regulation of histone H3-K9 methylation (GO:0051570)3.01339142
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.00425047
96DNA topological change (GO:0006265)3.00345802
97viral mRNA export from host cell nucleus (GO:0046784)3.00220775
98DNA replication-independent nucleosome assembly (GO:0006336)2.99837818
99DNA replication-independent nucleosome organization (GO:0034724)2.99837818
100negative regulation of ligase activity (GO:0051352)2.98698506
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98698506
102chaperone-mediated protein complex assembly (GO:0051131)2.97707178
103pteridine-containing compound biosynthetic process (GO:0042559)2.97658313
104establishment of chromosome localization (GO:0051303)2.96542541
105mitotic spindle assembly checkpoint (GO:0007094)2.95184653
106chromatin remodeling at centromere (GO:0031055)2.94732177
107positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94376569
108negative regulation of mRNA metabolic process (GO:1903312)2.93864273
109ATP-dependent chromatin remodeling (GO:0043044)2.93846306
110mitotic chromosome condensation (GO:0007076)2.93833671
111regulation of chromosome segregation (GO:0051983)2.93709815
112spliceosomal complex assembly (GO:0000245)2.93355536
113alternative mRNA splicing, via spliceosome (GO:0000380)2.92615394
114regulation of centriole replication (GO:0046599)2.92594170
115CENP-A containing nucleosome assembly (GO:0034080)2.92375169
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92153913
117regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92153913
118histone H2A acetylation (GO:0043968)2.91052214
119spindle assembly checkpoint (GO:0071173)2.90464742
120paraxial mesoderm development (GO:0048339)2.90313150
121negative regulation of chromosome segregation (GO:0051985)2.89120925
122DNA damage response, detection of DNA damage (GO:0042769)2.88565324
123RNA-dependent DNA replication (GO:0006278)2.88234596
124regulation of sister chromatid segregation (GO:0033045)2.86376303
125regulation of mitotic sister chromatid separation (GO:0010965)2.86376303
126regulation of mitotic sister chromatid segregation (GO:0033047)2.86376303
127negative regulation of mitotic sister chromatid separation (GO:2000816)2.85236984
128negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85236984
129negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85236984
130negative regulation of sister chromatid segregation (GO:0033046)2.85236984
131spliceosomal tri-snRNP complex assembly (GO:0000244)2.85226571
132spindle checkpoint (GO:0031577)2.84475961
133mitotic spindle checkpoint (GO:0071174)2.84384070
134kinetochore organization (GO:0051383)2.83703927
135mitochondrial RNA metabolic process (GO:0000959)2.82107600
136regulation of mitotic spindle checkpoint (GO:1903504)2.78886682
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78886682
138regulation of translational elongation (GO:0006448)2.77942743

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.22329993
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.61583516
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.24481317
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71978257
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70053222
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.51345809
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97380610
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96222334
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.77437900
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73323122
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.69019111
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.66543532
13* XRN2_22483619_ChIP-Seq_HELA_Human2.52679486
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44220647
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.39766482
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39580763
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36887808
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35978758
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31563881
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.25813489
21AR_21909140_ChIP-Seq_LNCAP_Human2.19612184
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13832414
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11552285
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.07801091
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00705290
26* MYC_22102868_ChIP-Seq_BL_Human1.98090436
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.97928931
28* TTF2_22483619_ChIP-Seq_HELA_Human1.95084954
29* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94780168
30* VDR_23849224_ChIP-Seq_CD4+_Human1.93762646
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.90063937
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87789480
33CIITA_25753668_ChIP-Seq_RAJI_Human1.87181927
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84820207
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84194204
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82197879
37* FOXP3_21729870_ChIP-Seq_TREG_Human1.77097766
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72185802
39GABP_19822575_ChIP-Seq_HepG2_Human1.72042320
40DCP1A_22483619_ChIP-Seq_HELA_Human1.69554573
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69348673
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65955744
43* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65409946
44KDM5A_27292631_Chip-Seq_BREAST_Human1.59363365
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58085156
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56984840
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53638935
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.51295660
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49386933
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.47815000
51ELK1_19687146_ChIP-ChIP_HELA_Human1.47686777
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47398428
53* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45631827
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44186381
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.41654357
56* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40778888
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40530521
58* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40302657
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39217286
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33420594
61* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30797872
62* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30760414
63* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29099961
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28059603
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28059603
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28059603
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25441642
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25128166
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24840381
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.23252479
71* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22734792
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21328617
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20815913
74NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19389786
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17667319
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.16339942
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15908771
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14701108
79* SRF_21415370_ChIP-Seq_HL-1_Mouse1.14260620
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.12604380
81TFEB_21752829_ChIP-Seq_HELA_Human1.11916861
82* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11254143
83* SOX17_20123909_ChIP-Seq_XEN_Mouse1.10800883
84* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10699749
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08599940
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08052753
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07419932
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03952399
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00294088
90* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99532184
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99223461
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97136115
93OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97095076
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95710210
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94125585
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92822625
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92345794
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90576150
99* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90113470
100TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89146031
101* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88024952
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87718729
103VDR_21846776_ChIP-Seq_THP-1_Human0.85495651
104MYC_18940864_ChIP-ChIP_HL60_Human0.84878916
105* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.84477846
106ZNF263_19887448_ChIP-Seq_K562_Human0.84260295
107CHD1_26751641_Chip-Seq_LNCaP_Human0.84005065
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82971708
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82009240
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.81498584
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80870665
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80629757
113* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80087578
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77567739
115CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75824039
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75548158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.91425437
2MP0004957_abnormal_blastocyst_morpholog4.41962017
3MP0010094_abnormal_chromosome_stability4.35302675
4MP0003111_abnormal_nucleus_morphology4.33937584
5MP0003077_abnormal_cell_cycle3.88986318
6MP0008057_abnormal_DNA_replication3.73896226
7MP0003123_paternal_imprinting3.45362275
8MP0008058_abnormal_DNA_repair2.92780013
9MP0001730_embryonic_growth_arrest2.85087283
10MP0010352_gastrointestinal_tract_polyps2.68925514
11MP0008007_abnormal_cellular_replicative2.68046821
12MP0008932_abnormal_embryonic_tissue2.67603556
13MP0000350_abnormal_cell_proliferation2.40331454
14MP0000537_abnormal_urethra_morphology2.24744040
15MP0003121_genomic_imprinting2.11270403
16MP0008877_abnormal_DNA_methylation2.08213966
17MP0005380_embryogenesis_phenotype2.07320957
18MP0001672_abnormal_embryogenesis/_devel2.07320957
19MP0002084_abnormal_developmental_patter2.07132123
20MP0001697_abnormal_embryo_size2.02558304
21MP0002085_abnormal_embryonic_tissue1.97682737
22MP0002396_abnormal_hematopoietic_system1.91190103
23MP0009697_abnormal_copulation1.87781945
24MP0003984_embryonic_growth_retardation1.87562851
25MP0004197_abnormal_fetal_growth/weight/1.87000029
26MP0003567_abnormal_fetal_cardiomyocyte1.84628111
27MP0002088_abnormal_embryonic_growth/wei1.83930233
28* MP0002080_prenatal_lethality1.83007978
29MP0010307_abnormal_tumor_latency1.75132316
30MP0005076_abnormal_cell_differentiation1.66791010
31* MP0002086_abnormal_extraembryonic_tissu1.62879062
32MP0010030_abnormal_orbit_morphology1.56495691
33MP0003786_premature_aging1.55985072
34MP0003119_abnormal_digestive_system1.55261605
35MP0002653_abnormal_ependyma_morphology1.52627649
36MP0003890_abnormal_embryonic-extraembry1.49805120
37MP0001293_anophthalmia1.47490767
38MP0006035_abnormal_mitochondrial_morpho1.41952254
39MP0003315_abnormal_perineum_morphology1.41633165
40MP0002254_reproductive_system_inflammat1.37980091
41MP0004808_abnormal_hematopoietic_stem1.37715877
42MP0009053_abnormal_anal_canal1.28922900
43* MP0000313_abnormal_cell_death1.28688002
44MP0003122_maternal_imprinting1.24873837
45MP0004133_heterotaxia1.21820538
46MP0003937_abnormal_limbs/digits/tail_de1.19613687
47MP0003941_abnormal_skin_development1.18784477
48MP0001849_ear_inflammation1.10343635
49MP0009672_abnormal_birth_weight1.09548444
50MP0000428_abnormal_craniofacial_morphol1.06810604
51MP0003861_abnormal_nervous_system1.05952357
52MP0002019_abnormal_tumor_incidence1.05634902
53MP0000490_abnormal_crypts_of1.05078452
54MP0001529_abnormal_vocalization1.04679658
55MP0002111_abnormal_tail_morphology1.04370695
56MP0009703_decreased_birth_body1.03207561
57MP0001346_abnormal_lacrimal_gland1.03054825
58MP0003718_maternal_effect1.00393353
59MP0003943_abnormal_hepatobiliary_system0.97910360
60MP0000579_abnormal_nail_morphology0.96835730
61MP0001661_extended_life_span0.96475711
62MP0002160_abnormal_reproductive_system0.94726800
63MP0000703_abnormal_thymus_morphology0.93538104
64MP0004264_abnormal_extraembryonic_tissu0.93352732
65MP0002210_abnormal_sex_determination0.92899174
66MP0003566_abnormal_cell_adhesion0.91437769
67MP0005384_cellular_phenotype0.89168023
68MP0001286_abnormal_eye_development0.87166455
69MP0001145_abnormal_male_reproductive0.86734549
70MP0001299_abnormal_eye_distance/0.86501144
71MP0004233_abnormal_muscle_weight0.85978026
72MP0005621_abnormal_cell_physiology0.82636778
73MP0003705_abnormal_hypodermis_morpholog0.82307425
74MP0002877_abnormal_melanocyte_morpholog0.81881444
75MP0002796_impaired_skin_barrier0.81538056
76MP0002233_abnormal_nose_morphology0.81292377
77MP0002092_abnormal_eye_morphology0.80579260
78MP0000358_abnormal_cell_content/0.80501173
79MP0000534_abnormal_ureter_morphology0.80399891
80MP0009278_abnormal_bone_marrow0.80214425
81MP0003136_yellow_coat_color0.80174946
82MP0005623_abnormal_meninges_morphology0.79915437
83MP0008770_decreased_survivor_rate0.79233041
84MP0003942_abnormal_urinary_system0.78767375
85MP0006292_abnormal_olfactory_placode0.78756845
86MP0002938_white_spotting0.78433198
87MP0003115_abnormal_respiratory_system0.77919253
88MP0000733_abnormal_muscle_development0.76878533
89MP0000647_abnormal_sebaceous_gland0.75757566
90MP0003221_abnormal_cardiomyocyte_apopto0.75661257
91MP0001915_intracranial_hemorrhage0.75360993
92MP0005501_abnormal_skin_physiology0.74144953
93MP0002697_abnormal_eye_size0.74018506
94MP0003935_abnormal_craniofacial_develop0.73938217
95MP0008789_abnormal_olfactory_epithelium0.73733098
96MP0002751_abnormal_autonomic_nervous0.73152123
97MP0005187_abnormal_penis_morphology0.72956891
98MP0005397_hematopoietic_system_phenotyp0.72943188
99MP0001545_abnormal_hematopoietic_system0.72943188
100MP0000566_synostosis0.72722309
101MP0001881_abnormal_mammary_gland0.72638979
102MP0000516_abnormal_urinary_system0.71994249
103MP0005367_renal/urinary_system_phenotyp0.71994249
104MP0010234_abnormal_vibrissa_follicle0.71023490
105MP0002114_abnormal_axial_skeleton0.70636763
106MP0003787_abnormal_imprinting0.70544789
107MP0003806_abnormal_nucleotide_metabolis0.70313042
108MP0000432_abnormal_head_morphology0.70193979
109MP0006072_abnormal_retinal_apoptosis0.69082068
110MP0001177_atelectasis0.68929175
111MP0002925_abnormal_cardiovascular_devel0.68831271
112MP0008995_early_reproductive_senescence0.68694509
113MP0001727_abnormal_embryo_implantation0.67873982
114MP0000653_abnormal_sex_gland0.67685505
115MP0001188_hyperpigmentation0.67296944
116MP0003755_abnormal_palate_morphology0.65889445
117MP0000049_abnormal_middle_ear0.65334095
118MP0000627_abnormal_mammary_gland0.64779737
119MP0009333_abnormal_splenocyte_physiolog0.64683438
120MP0005395_other_phenotype0.64091729
121MP0005389_reproductive_system_phenotype0.64068460
122MP0002081_perinatal_lethality0.63028671
123MP0004185_abnormal_adipocyte_glucose0.62884234
124MP0006036_abnormal_mitochondrial_physio0.62511836
125MP0001929_abnormal_gametogenesis0.61734289
126MP0005023_abnormal_wound_healing0.61077867
127MP0003385_abnormal_body_wall0.60643461
128MP0005394_taste/olfaction_phenotype0.59979203
129MP0003186_abnormal_redox_activity0.57841188
130MP0002102_abnormal_ear_morphology0.57790148
131MP0005408_hypopigmentation0.57482360

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.29793252
2Colon cancer (HP:0003003)4.01816679
3Birth length less than 3rd percentile (HP:0003561)3.90852100
4Medulloblastoma (HP:0002885)3.57596122
5Abnormality of the labia minora (HP:0012880)3.52523561
6Cortical dysplasia (HP:0002539)3.38711933
7Selective tooth agenesis (HP:0001592)3.37022000
8Abnormality of glycolysis (HP:0004366)3.26925349
9Breast hypoplasia (HP:0003187)3.24911102
10Nephroblastoma (Wilms tumor) (HP:0002667)3.10547666
11Reticulocytopenia (HP:0001896)3.05563616
12Multiple enchondromatosis (HP:0005701)3.02345494
13Patellar aplasia (HP:0006443)3.02270766
14Abnormality of the astrocytes (HP:0100707)3.01887114
15Astrocytoma (HP:0009592)3.01887114
16Embryonal renal neoplasm (HP:0011794)2.95236164
17Abnormality of the anterior horn cell (HP:0006802)2.92291363
18Degeneration of anterior horn cells (HP:0002398)2.92291363
19Agnosia (HP:0010524)2.91916635
20Carpal bone hypoplasia (HP:0001498)2.91763060
21Aplasia/Hypoplasia of the patella (HP:0006498)2.87610671
22Abnormal number of incisors (HP:0011064)2.82948020
23Cerebral hypomyelination (HP:0006808)2.82176892
24Increased serum pyruvate (HP:0003542)2.81429082
25Proximal placement of thumb (HP:0009623)2.80671233
26Glioma (HP:0009733)2.78235058
27Deviation of the thumb (HP:0009603)2.73665393
28Increased nuchal translucency (HP:0010880)2.64297823
29Abnormality of cells of the erythroid lineage (HP:0012130)2.62580322
30Oral leukoplakia (HP:0002745)2.62114362
31Spastic diplegia (HP:0001264)2.59848268
32Absent radius (HP:0003974)2.58086568
33Microvesicular hepatic steatosis (HP:0001414)2.53351770
34Neoplasm of the pancreas (HP:0002894)2.48391814
35Neoplasm of the oral cavity (HP:0100649)2.47876383
36Chromsome breakage (HP:0040012)2.44638999
37Rhabdomyosarcoma (HP:0002859)2.44426852
38Abnormality of methionine metabolism (HP:0010901)2.43672128
39Absent forearm bone (HP:0003953)2.42946814
40Aplasia involving forearm bones (HP:0009822)2.42946814
41Basal cell carcinoma (HP:0002671)2.38654340
42Abnormal gallbladder physiology (HP:0012438)2.37288381
43Cholecystitis (HP:0001082)2.37288381
44Progressive external ophthalmoplegia (HP:0000590)2.37130135
45Rough bone trabeculation (HP:0100670)2.35304735
46Abnormal number of erythroid precursors (HP:0012131)2.34575937
47Volvulus (HP:0002580)2.34127002
48Abnormality of the carotid arteries (HP:0005344)2.31337014
49Impulsivity (HP:0100710)2.31147419
50Abnormality of the duodenum (HP:0002246)2.30802074
51Atresia of the external auditory canal (HP:0000413)2.29954143
52Meckel diverticulum (HP:0002245)2.25468150
53Missing ribs (HP:0000921)2.25437014
54Supernumerary spleens (HP:0009799)2.24477939
55Aplasia/Hypoplasia of the sternum (HP:0006714)2.24275040
56Atrophy/Degeneration involving motor neurons (HP:0007373)2.23614408
57Horseshoe kidney (HP:0000085)2.19975794
58Amaurosis fugax (HP:0100576)2.17953332
59Absent thumb (HP:0009777)2.17258718
60Biliary tract neoplasm (HP:0100574)2.16467168
61Esophageal atresia (HP:0002032)2.14507837
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14410741
63Choanal atresia (HP:0000453)2.12925412
64Abnormality of chromosome stability (HP:0003220)2.12826439
65Shoulder girdle muscle weakness (HP:0003547)2.11933297
66Abnormality of the ileum (HP:0001549)2.11378545
67Overlapping toe (HP:0001845)2.07899776
68Pelvic girdle muscle weakness (HP:0003749)2.06636278
69Aplastic anemia (HP:0001915)2.06019073
70Myelodysplasia (HP:0002863)2.03728072
71Abnormality of the preputium (HP:0100587)2.02848090
72Neoplasm of striated muscle (HP:0009728)2.02743628
73Postnatal microcephaly (HP:0005484)2.02537210
7411 pairs of ribs (HP:0000878)2.01062329
75Aplasia/hypoplasia of the humerus (HP:0006507)1.99673440
76Pancreatic islet-cell hyperplasia (HP:0004510)1.99247407
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99239035
78Short 4th metacarpal (HP:0010044)1.99239035
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98852824
80Sloping forehead (HP:0000340)1.97377458
81Renal duplication (HP:0000075)1.97192174
82Trismus (HP:0000211)1.95051619
83Macrocytic anemia (HP:0001972)1.94418379
84Abnormality of homocysteine metabolism (HP:0010919)1.92919620
85Homocystinuria (HP:0002156)1.92919620
86Hyperacusis (HP:0010780)1.92860445
87High anterior hairline (HP:0009890)1.92557531
88Abnormal lung lobation (HP:0002101)1.91959163
89Glossoptosis (HP:0000162)1.91497347
90Tracheoesophageal fistula (HP:0002575)1.91339514
91Ectopic kidney (HP:0000086)1.90946916
92Premature graying of hair (HP:0002216)1.90876996
93Supernumerary bones of the axial skeleton (HP:0009144)1.90865109
94Spinal muscular atrophy (HP:0007269)1.90164822
95Duodenal stenosis (HP:0100867)1.87265059
96Small intestinal stenosis (HP:0012848)1.87265059
97Facial cleft (HP:0002006)1.86970531
98Neoplasm of the adrenal gland (HP:0100631)1.86818535
99Prominent metopic ridge (HP:0005487)1.85828992
100Cellular immunodeficiency (HP:0005374)1.85113869
101Abnormality of the calcaneus (HP:0008364)1.85036751
102Asplenia (HP:0001746)1.84664746
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.84429572
104Adenoma sebaceum (HP:0009720)1.83789692
105Angiofibromas (HP:0010615)1.83789692
106Aplasia/Hypoplasia of the spleen (HP:0010451)1.82808952
107Neoplasm of the colon (HP:0100273)1.82401334
108Cafe-au-lait spot (HP:0000957)1.82128959
109Neuroblastoma (HP:0003006)1.81064411
110Primitive neuroectodermal tumor (HP:0030065)1.81064411
111Neuroblastic tumors (HP:0004376)1.81064411
112Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.81064411
113Secondary amenorrhea (HP:0000869)1.80970131
114Supernumerary ribs (HP:0005815)1.80182229
115Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78708620
116Stenosis of the external auditory canal (HP:0000402)1.78232212
117Embryonal neoplasm (HP:0002898)1.78069366
118Malignant gastrointestinal tract tumors (HP:0006749)1.77504026
119Gastrointestinal carcinoma (HP:0002672)1.77504026
120Triphalangeal thumb (HP:0001199)1.77015487
121Progressive muscle weakness (HP:0003323)1.75915302
122Preauricular skin tag (HP:0000384)1.75713863
123Skin tags (HP:0010609)1.72733267
124Neoplasm of the adrenal cortex (HP:0100641)1.72609133
125Facial hemangioma (HP:0000329)1.72090171
126Abnormality of the musculature of the pelvis (HP:0001469)1.71672907
127Abnormality of the hip-girdle musculature (HP:0001445)1.71672907
128Shawl scrotum (HP:0000049)1.71564773
129Breast aplasia (HP:0100783)1.71241868
130Premature ovarian failure (HP:0008209)1.70894142
131Abdominal situs inversus (HP:0003363)1.69964884
132Abnormality of abdominal situs (HP:0011620)1.69964884
133Breast carcinoma (HP:0003002)1.69949364
134Skull defect (HP:0001362)1.69250328
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68653301
136Hypoglycemic seizures (HP:0002173)1.68577130
137Urethral obstruction (HP:0000796)1.67746355
138Increased hepatocellular lipid droplets (HP:0006565)1.66217040
139Insomnia (HP:0100785)1.65176772
140Megaloblastic anemia (HP:0001889)1.64655372
141Abnormality of sulfur amino acid metabolism (HP:0004339)1.63123561
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58553012
143Ovarian neoplasm (HP:0100615)1.58386913
144Neuroectodermal neoplasm (HP:0030061)1.56910104
145Neuroepithelial neoplasm (HP:0030063)1.56910104
146Nervous tissue neoplasm (HP:0030060)1.56910104
147Overriding aorta (HP:0002623)1.56304669
148Abnormality of serum amino acid levels (HP:0003112)1.55876985
149Abnormality of endocrine pancreas physiology (HP:0012093)1.54700595
150Abnormality of the pancreatic islet cells (HP:0006476)1.54700595
151Abnormality of the metopic suture (HP:0005556)1.54178105
152Abnormality of cochlea (HP:0000375)1.54111819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.60341021
2CDC74.29787429
3BUB14.20447941
4PNCK3.51187605
5EEF2K3.38796903
6PASK2.74884891
7PBK2.74412416
8NEK12.70408900
9MST42.53573832
10EPHA22.50067855
11VRK22.49806998
12CDK122.44664240
13TTK2.44228883
14NEK22.41663437
15SRPK12.38629539
16RPS6KB22.33270397
17* TSSK62.30441998
18MKNK12.14885348
19TRIM282.02635675
20EIF2AK11.97582539
21ALK1.94103961
22PLK41.90621911
23TAF11.88451877
24TGFBR11.84931532
25PLK11.83598739
26* PLK31.74537290
27ATR1.68992739
28TESK21.63996830
29CDK71.58712676
30BRD41.49521648
31CHEK11.46228599
32SMG11.44059059
33MAP3K81.43339806
34MKNK21.42145055
35PAK41.35669005
36BRSK21.32044931
37TNIK1.28547900
38* AURKB1.26786285
39LATS21.26115869
40CDK41.23707219
41CHEK21.21042245
42ACVR1B1.19703242
43SCYL21.19460612
44AURKA1.12224578
45PKN21.12053742
46MAP3K101.11837929
47EIF2AK21.09101755
48CDK21.05943477
49BRSK10.99701507
50ATM0.98644775
51ERBB40.98072526
52STK100.90326960
53BCR0.89323189
54EIF2AK30.89274622
55VRK10.86567643
56DYRK30.86286654
57NME20.86077140
58* CSNK1E0.84245501
59MTOR0.84181136
60MAP3K90.83165069
61LRRK20.83009407
62* CSNK2A20.82276350
63AKT30.82040455
64NUAK10.81647963
65CDK60.79921090
66CDK10.79655410
67STK160.74450250
68PAK10.70767646
69WNK30.68988140
70PRKCI0.68846879
71RPS6KA40.67822021
72PAK20.63729735
73CCNB10.62852285
74FGFR10.62072522
75CLK10.59297296
76MST1R0.58300311
77STK38L0.58040193
78PRKDC0.55540107
79* CSNK2A10.53751251
80PDK20.53318105
81SIK30.53103365
82CSNK1G10.53003847
83ILK0.52841108
84MELK0.52551641
85PIM10.52019876
86CSNK1D0.51013342
87AKT20.47552004
88TESK10.46969961
89CSNK1G30.45967976
90DAPK10.45826527
91STK40.45633867
92MAPKAPK50.45551212
93STK30.45453532
94PLK20.43968215
95CAMK1G0.43876472
96NME10.41889698
97FLT30.39299197
98MET0.39032238
99CDK90.38949559
100MAPK140.38326486
101NTRK10.38179506
102MINK10.37283750
103ZAK0.36941327
104ERBB30.35520887
105RPS6KB10.34228527
106GSK3B0.33118266
107CDK11A0.32236640
108CDK140.31022954
109CAMK1D0.30922248
110RAF10.30458118
111CDK30.30231573
112CDK80.30154978
113LIMK10.30019058
114STK240.29960941
115KSR10.29396482
116BMPR1B0.29069297
117CDK150.28438928
118CDK180.28057139
119PIM20.27516262
120TRIB30.27167634
121MAPK90.27020033
122RPS6KA10.26419215
123LATS10.25246710
124AKT10.22892664
125GRK60.22486595
126MAPK10.21776472
127MAPKAPK30.21629175
128MAPK100.21315986
129CSNK1A1L0.20386977
130BRAF0.20113711

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.45170406
2Mismatch repair_Homo sapiens_hsa034304.00576368
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.96640788
4Spliceosome_Homo sapiens_hsa030403.72557336
5RNA transport_Homo sapiens_hsa030133.62553404
6RNA polymerase_Homo sapiens_hsa030203.17681418
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.13411712
8Proteasome_Homo sapiens_hsa030503.13264026
9Ribosome_Homo sapiens_hsa030102.96463223
10Cell cycle_Homo sapiens_hsa041102.78969003
11One carbon pool by folate_Homo sapiens_hsa006702.71211159
12Nucleotide excision repair_Homo sapiens_hsa034202.68979374
13Base excision repair_Homo sapiens_hsa034102.60677842
14Homologous recombination_Homo sapiens_hsa034402.39708484
15mRNA surveillance pathway_Homo sapiens_hsa030152.20119206
16Pyrimidine metabolism_Homo sapiens_hsa002402.08863603
17RNA degradation_Homo sapiens_hsa030181.96651168
18Non-homologous end-joining_Homo sapiens_hsa034501.88671217
19Fanconi anemia pathway_Homo sapiens_hsa034601.74504078
20Protein export_Homo sapiens_hsa030601.62192590
21Basal transcription factors_Homo sapiens_hsa030221.57668744
22Pyruvate metabolism_Homo sapiens_hsa006201.50809158
23Steroid biosynthesis_Homo sapiens_hsa001001.44545876
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44074584
25Oocyte meiosis_Homo sapiens_hsa041141.43764991
26p53 signaling pathway_Homo sapiens_hsa041151.43236102
27Epstein-Barr virus infection_Homo sapiens_hsa051691.40241251
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38903856
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29530155
30Propanoate metabolism_Homo sapiens_hsa006401.26511391
31Purine metabolism_Homo sapiens_hsa002301.16150814
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14921296
33* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14591345
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11843583
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01684947
36Viral carcinogenesis_Homo sapiens_hsa052031.00215091
37Hippo signaling pathway_Homo sapiens_hsa043900.95282741
38Thyroid cancer_Homo sapiens_hsa052160.92187141
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91649519
40HTLV-I infection_Homo sapiens_hsa051660.91529166
41Biosynthesis of amino acids_Homo sapiens_hsa012300.91102444
42MicroRNAs in cancer_Homo sapiens_hsa052060.90640935
43Fatty acid elongation_Homo sapiens_hsa000620.89218488
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88994271
45Basal cell carcinoma_Homo sapiens_hsa052170.87432769
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81036996
47Colorectal cancer_Homo sapiens_hsa052100.80433197
48Lysine degradation_Homo sapiens_hsa003100.80212002
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.77058190
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75993063
51* Antigen processing and presentation_Homo sapiens_hsa046120.75337512
52Hedgehog signaling pathway_Homo sapiens_hsa043400.73967879
53Folate biosynthesis_Homo sapiens_hsa007900.71203696
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.70758950
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.69502223
56Glutathione metabolism_Homo sapiens_hsa004800.64666814
57Arginine and proline metabolism_Homo sapiens_hsa003300.62446809
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62139759
59Chronic myeloid leukemia_Homo sapiens_hsa052200.61450872
60mTOR signaling pathway_Homo sapiens_hsa041500.60830703
61TGF-beta signaling pathway_Homo sapiens_hsa043500.59563084
62Small cell lung cancer_Homo sapiens_hsa052220.59128462
63Herpes simplex infection_Homo sapiens_hsa051680.57740866
64Notch signaling pathway_Homo sapiens_hsa043300.57203753
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56784330
66Pentose phosphate pathway_Homo sapiens_hsa000300.55090198
67HIF-1 signaling pathway_Homo sapiens_hsa040660.54074965
68Adherens junction_Homo sapiens_hsa045200.52895361
69Tight junction_Homo sapiens_hsa045300.52533034
70Wnt signaling pathway_Homo sapiens_hsa043100.52225193
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50941911
72Fatty acid metabolism_Homo sapiens_hsa012120.47803457
73Parkinsons disease_Homo sapiens_hsa050120.45239255
74Bladder cancer_Homo sapiens_hsa052190.45234442
75* Pathways in cancer_Homo sapiens_hsa052000.44300837
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42401366
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41557501
78Selenocompound metabolism_Homo sapiens_hsa004500.41365961
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41112966
80Metabolic pathways_Homo sapiens_hsa011000.41103358
81Endometrial cancer_Homo sapiens_hsa052130.40566669
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40281992
83Non-small cell lung cancer_Homo sapiens_hsa052230.40198477
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39458140
85Arginine biosynthesis_Homo sapiens_hsa002200.38308695
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38215832
87Legionellosis_Homo sapiens_hsa051340.38150305
88* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37898444
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36940436
90Shigellosis_Homo sapiens_hsa051310.36454737
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.35146926
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34701316
93Vitamin B6 metabolism_Homo sapiens_hsa007500.34692681
94Systemic lupus erythematosus_Homo sapiens_hsa053220.34572632
95Proteoglycans in cancer_Homo sapiens_hsa052050.34138058
96Carbon metabolism_Homo sapiens_hsa012000.34067967
97Hepatitis B_Homo sapiens_hsa051610.34029576
98Viral myocarditis_Homo sapiens_hsa054160.32480230
99Alcoholism_Homo sapiens_hsa050340.31630464
100Apoptosis_Homo sapiens_hsa042100.31318281
101Melanoma_Homo sapiens_hsa052180.30980903
102Sulfur relay system_Homo sapiens_hsa041220.30396068
103Acute myeloid leukemia_Homo sapiens_hsa052210.29468888
104Huntingtons disease_Homo sapiens_hsa050160.28583076
105Fructose and mannose metabolism_Homo sapiens_hsa000510.27880835
106Glioma_Homo sapiens_hsa052140.27561077
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25641955
108Renal cell carcinoma_Homo sapiens_hsa052110.22983946
109Galactose metabolism_Homo sapiens_hsa000520.22163855
110* Prostate cancer_Homo sapiens_hsa052150.22140955
111Oxidative phosphorylation_Homo sapiens_hsa001900.21964084
112N-Glycan biosynthesis_Homo sapiens_hsa005100.21741634
113Butanoate metabolism_Homo sapiens_hsa006500.21554882
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.21347699
115FoxO signaling pathway_Homo sapiens_hsa040680.20130120
116* Estrogen signaling pathway_Homo sapiens_hsa049150.18219450
117Melanogenesis_Homo sapiens_hsa049160.17928586
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16090524
119beta-Alanine metabolism_Homo sapiens_hsa004100.15908072
120* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15864000
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15660210
122Glucagon signaling pathway_Homo sapiens_hsa049220.13331951
123Gap junction_Homo sapiens_hsa045400.13309248
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12801692
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11950538
126T cell receptor signaling pathway_Homo sapiens_hsa046600.11892345
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11655674
128Sulfur metabolism_Homo sapiens_hsa009200.11636995
129Long-term potentiation_Homo sapiens_hsa047200.11071022
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.10509735
131Fatty acid biosynthesis_Homo sapiens_hsa000610.10143343
132Pancreatic cancer_Homo sapiens_hsa052120.09947137
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09782798
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.09363157
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07924081
136Measles_Homo sapiens_hsa051620.07821418
137Thyroid hormone synthesis_Homo sapiens_hsa049180.07404637
138Rap1 signaling pathway_Homo sapiens_hsa040150.07022422
139Vitamin digestion and absorption_Homo sapiens_hsa049770.06867845
140Alzheimers disease_Homo sapiens_hsa050100.04740644
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.03978771

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