ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of 5.8S rRNA (GO:0000460)	4.48342922
2	DNA deamination (GO:0045006)	4.37430627
3	ribosome assembly (GO:0042255)	4.21243818
4	cullin deneddylation (GO:0010388)	4.10870354
5	rRNA modification (GO:0000154)	4.10063279
6	proteasome assembly (GO:0043248)	3.91973130
7	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.85479285
8	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.83302141
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.80883216
10	protein deneddylation (GO:0000338)	3.79142902
11	pseudouridine synthesis (GO:0001522)	3.77570626
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.77300478
13	protein neddylation (GO:0045116)	3.77286044
14	rRNA methylation (GO:0031167)	3.71337875
15	DNA double-strand break processing (GO:0000729)	3.68842197
16	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.60808625
17	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.60808625
18	isotype switching (GO:0045190)	3.60808625
19	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.56383457
20	termination of RNA polymerase III transcription (GO:0006386)	3.56383457
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.55643689
22	ATP synthesis coupled proton transport (GO:0015986)	3.55643689
23	regulation of mitotic spindle checkpoint (GO:1903504)	3.46629202
24	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.46629202
25	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.46264386
26	chromatin remodeling at centromere (GO:0031055)	3.42565953
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.39626648
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.39626648
29	NADH dehydrogenase complex assembly (GO:0010257)	3.39626648
30	spliceosomal snRNP assembly (GO:0000387)	3.35211571
31	protein complex biogenesis (GO:0070271)	3.32863262
32	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.32361467
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.29971809
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.29971809
35	mitochondrial respiratory chain complex assembly (GO:0033108)	3.29961145
36	DNA damage response, detection of DNA damage (GO:0042769)	3.29374007
37	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.26734218
38	establishment of integrated proviral latency (GO:0075713)	3.24769345
39	DNA replication-dependent nucleosome assembly (GO:0006335)	3.24597160
40	DNA replication-dependent nucleosome organization (GO:0034723)	3.24597160
41	CENP-A containing nucleosome assembly (GO:0034080)	3.23393250
42	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.17244249
43	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.14485048
44	DNA catabolic process, exonucleolytic (GO:0000738)	3.13941072
45	negative regulation of telomere maintenance (GO:0032205)	3.13716758
46	DNA replication checkpoint (GO:0000076)	3.13301151
47	histone mRNA metabolic process (GO:0008334)	3.12185145
48	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.10726194
49	chaperone-mediated protein transport (GO:0072321)	3.10479763
50	tRNA processing (GO:0008033)	3.08961300
51	mitochondrial RNA metabolic process (GO:0000959)	3.08817529
52	7-methylguanosine mRNA capping (GO:0006370)	3.08214050
53	respiratory chain complex IV assembly (GO:0008535)	3.07660188
54	histone exchange (GO:0043486)	3.05224285
55	tRNA metabolic process (GO:0006399)	3.03908555
56	replication fork processing (GO:0031297)	3.02957142
57	RNA capping (GO:0036260)	3.00685223
58	7-methylguanosine RNA capping (GO:0009452)	3.00685223
59	regulation of centriole replication (GO:0046599)	3.00583034
60	regulation of cellular amino acid metabolic process (GO:0006521)	3.00469518
61	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.99491788
62	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.94935949
63	rRNA processing (GO:0006364)	2.94787987
64	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.93985777
65	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.93985777
66	termination of RNA polymerase I transcription (GO:0006363)	2.93792340
67	IMP biosynthetic process (GO:0006188)	2.93410753
68	negative regulation of ligase activity (GO:0051352)	2.91227543
69	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.91227543
70	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.90326799
71	rRNA metabolic process (GO:0016072)	2.90102265
72	tRNA aminoacylation (GO:0043039)	2.89789276
73	amino acid activation (GO:0043038)	2.89789276
74	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.89417128
75	tRNA modification (GO:0006400)	2.86336765
76	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.86242650
77	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.86242650
78	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.86242650
79	peptidyl-histidine modification (GO:0018202)	2.85058833
80	tRNA aminoacylation for protein translation (GO:0006418)	2.85047177
81	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.85012243
82	L-fucose catabolic process (GO:0042355)	2.84934656
83	fucose catabolic process (GO:0019317)	2.84934656
84	L-fucose metabolic process (GO:0042354)	2.84934656
85	ncRNA metabolic process (GO:0034660)	2.83697959
86	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.83193391
87	ribosome biogenesis (GO:0042254)	2.82904724
88	protein-cofactor linkage (GO:0018065)	2.82618317
89	ncRNA catabolic process (GO:0034661)	2.82609469
90	folic acid-containing compound biosynthetic process (GO:0009396)	2.82365981
91	rRNA catabolic process (GO:0016075)	2.79443243
92	somatic diversification of immunoglobulins (GO:0016445)	2.79332308
93	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.77390384
94	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.77390384
95	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.75187570
96	preassembly of GPI anchor in ER membrane (GO:0016254)	2.74179896
97	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.73292239
98	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.73292239
99	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.72206965
100	DNA-templated transcription, termination (GO:0006353)	2.71969650

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.03729270
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.33282453
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.84526082
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.18693606
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.12411262
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.91424571
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.88178387
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.83993318
9	E2F7_22180533_ChIP-Seq_HELA_Human	2.81640894
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.79599239
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.78945520
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.77533369
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.66210314
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.64172555
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.59666961
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.56502127
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.50403566
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.45339809
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.32517902
20	VDR_22108803_ChIP-Seq_LS180_Human	2.27114114
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.24486165
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.10711931
23	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.05790095
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.03745491
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00563117
26	MYC_18940864_ChIP-ChIP_HL60_Human	2.00295707
27	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.96952640
28	* EWS_26573619_Chip-Seq_HEK293_Human	1.96453032
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.90967665
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.86172357
31	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.84065275
32	DCP1A_22483619_ChIP-Seq_HELA_Human	1.82817304
33	FUS_26573619_Chip-Seq_HEK293_Human	1.78736323
34	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.78189426
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.77431933
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.74370916
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.70684716
38	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.67881581
39	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.66673757
40	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65351530
41	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.64435905
42	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.62656312
43	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.61366683
44	TAF15_26573619_Chip-Seq_HEK293_Human	1.57840761
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49591416
46	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.48244405
47	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.48050304
48	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.43036466
49	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.42519199
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.41643903
51	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.36097749
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34552575
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.33342371
54	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.33063745
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.31802322
56	XRN2_22483619_ChIP-Seq_HELA_Human	1.31333857
57	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.30243974
58	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.29703233
59	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28765560
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.27945229
61	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25316057
62	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.24659653
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.24192576
64	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.23683668
65	P300_19829295_ChIP-Seq_ESCs_Human	1.22225842
66	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.19563245
67	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.19558337
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19316558
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15952434
70	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.11864229
71	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10543811
72	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.10471042
73	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.08437685
74	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08011046
75	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06853622
76	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.06250741
77	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.05351392
78	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.00215930
79	KDM5A_27292631_Chip-Seq_BREAST_Human	0.99628915
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97770652
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97770652
82	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.96473351
83	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.96104922
84	CBP_20019798_ChIP-Seq_JUKART_Human	0.95937226
85	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.95937226
86	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95758361
87	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95189511
88	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.93881108
89	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91600555
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91600555
91	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.90526073
92	CIITA_25753668_ChIP-Seq_RAJI_Human	0.90390034
93	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89741713
94	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.89105773
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.89053931
96	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.86569354
97	ER_23166858_ChIP-Seq_MCF-7_Human	0.82982905
98	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.82200866
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.81570949
100	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.80971802

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.08257149
2	MP0008058_abnormal_DNA_repair	3.80896242
3	MP0003693_abnormal_embryo_hatching	3.10299844
4	MP0010094_abnormal_chromosome_stability	3.03633907
5	MP0002102_abnormal_ear_morphology	2.82584392
6	MP0003787_abnormal_imprinting	2.77133691
7	MP0004957_abnormal_blastocyst_morpholog	2.59261253
8	MP0006072_abnormal_retinal_apoptosis	2.46404090
9	MP0003786_premature_aging	2.29809788
10	MP0003111_abnormal_nucleus_morphology	2.21006206
11	MP0003121_genomic_imprinting	2.06226396
12	MP0006292_abnormal_olfactory_placode	2.05255643
13	MP0003718_maternal_effect	2.04332155
14	MP0006035_abnormal_mitochondrial_morpho	2.04067087
15	MP0005084_abnormal_gallbladder_morpholo	2.02527907
16	MP0001529_abnormal_vocalization	2.01901514
17	MP0003122_maternal_imprinting	1.90371547
18	MP0005645_abnormal_hypothalamus_physiol	1.86569757
19	MP0009697_abnormal_copulation	1.84783583
20	MP0008007_abnormal_cellular_replicative	1.77214617
21	MP0006036_abnormal_mitochondrial_physio	1.74903868
22	MP0003077_abnormal_cell_cycle	1.71029627
23	MP0004147_increased_porphyrin_level	1.65959747
24	MP0002837_dystrophic_cardiac_calcinosis	1.58070321
25	MP0000372_irregular_coat_pigmentation	1.55817315
26	MP0008872_abnormal_physiological_respon	1.55589081
27	MP0003195_calcinosis	1.54421007
28	MP0001293_anophthalmia	1.53898681
29	MP0001984_abnormal_olfaction	1.53055018
30	MP0002736_abnormal_nociception_after	1.50832650
31	MP0001968_abnormal_touch/_nociception	1.50671619
32	MP0001188_hyperpigmentation	1.49047378
33	MP0009046_muscle_twitch	1.46771438
34	MP0005253_abnormal_eye_physiology	1.41263701
35	MP0002938_white_spotting	1.40876350
36	MP0003011_delayed_dark_adaptation	1.40723864
37	MP0005551_abnormal_eye_electrophysiolog	1.39917077
38	MP0003567_abnormal_fetal_cardiomyocyte	1.39692876
39	MP0008932_abnormal_embryonic_tissue	1.39621474
40	MP0008875_abnormal_xenobiotic_pharmacok	1.33690044
41	MP0000569_abnormal_digit_pigmentation	1.30520043
42	MP0006276_abnormal_autonomic_nervous	1.26325038
43	MP0003186_abnormal_redox_activity	1.25143353
44	MP0008789_abnormal_olfactory_epithelium	1.20048346
45	MP0002751_abnormal_autonomic_nervous	1.18228257
46	MP0000631_abnormal_neuroendocrine_gland	1.17764801
47	MP0003806_abnormal_nucleotide_metabolis	1.14720200
48	MP0008057_abnormal_DNA_replication	1.11527765
49	MP0004145_abnormal_muscle_electrophysio	1.10012202
50	MP0005646_abnormal_pituitary_gland	1.08930482
51	MP0008995_early_reproductive_senescence	1.08453356
52	MP0001929_abnormal_gametogenesis	1.07359387
53	MP0002163_abnormal_gland_morphology	1.06071307
54	MP0003890_abnormal_embryonic-extraembry	1.04523919
55	MP0002138_abnormal_hepatobiliary_system	1.04479906
56	MP0002272_abnormal_nervous_system	1.03312921
57	MP0002210_abnormal_sex_determination	1.02867440
58	MP0004142_abnormal_muscle_tone	0.99717780
59	MP0005075_abnormal_melanosome_morpholog	0.98411980
60	MP0002234_abnormal_pharynx_morphology	0.98158111
61	MP0009745_abnormal_behavioral_response	0.96720328
62	MP0003119_abnormal_digestive_system	0.93232306
63	MP0005410_abnormal_fertilization	0.93109882
64	MP0001905_abnormal_dopamine_level	0.92338286
65	MP0003937_abnormal_limbs/digits/tail_de	0.91711729
66	MP0003880_abnormal_central_pattern	0.91666394
67	MP0002160_abnormal_reproductive_system	0.90923716
68	MP0001919_abnormal_reproductive_system	0.90438468
69	MP0005394_taste/olfaction_phenotype	0.89914188
70	MP0005499_abnormal_olfactory_system	0.89914188
71	MP0005389_reproductive_system_phenotype	0.86964389
72	MP0005671_abnormal_response_to	0.85793061
73	MP0004133_heterotaxia	0.85557278
74	MP0005379_endocrine/exocrine_gland_phen	0.85479541
75	MP0001986_abnormal_taste_sensitivity	0.85313005
76	MP0000427_abnormal_hair_cycle	0.85112386
77	MP0000358_abnormal_cell_content/	0.84153542
78	MP0004885_abnormal_endolymph	0.84014915
79	MP0002735_abnormal_chemical_nociception	0.83488892
80	MP0000653_abnormal_sex_gland	0.81943787
81	MP0001145_abnormal_male_reproductive	0.81302787
82	MP0002638_abnormal_pupillary_reflex	0.81138867
83	MP0001730_embryonic_growth_arrest	0.80807880
84	MP0000647_abnormal_sebaceous_gland	0.80140025
85	MP0005332_abnormal_amino_acid	0.77189413
86	MP0003698_abnormal_male_reproductive	0.77101843
87	MP0004215_abnormal_myocardial_fiber	0.76503339
88	MP0004043_abnormal_pH_regulation	0.75299300
89	MP0002084_abnormal_developmental_patter	0.73082763
90	MP0001873_stomach_inflammation	0.72890691
91	MP0002090_abnormal_vision	0.71520855
92	MP0001286_abnormal_eye_development	0.71493351
93	MP0002254_reproductive_system_inflammat	0.71410356
94	MP0001486_abnormal_startle_reflex	0.70306638
95	MP0002733_abnormal_thermal_nociception	0.69946828
96	MP0001485_abnormal_pinna_reflex	0.69801465
97	MP0001697_abnormal_embryo_size	0.69743044
98	MP0008775_abnormal_heart_ventricle	0.68897994
99	MP0002184_abnormal_innervation	0.67907646
100	MP0004742_abnormal_vestibular_system	0.65682363

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.01111798
2	Acute encephalopathy (HP:0006846)	3.67574008
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.46599370
4	Abnormality of the labia minora (HP:0012880)	3.44034838
5	Increased CSF lactate (HP:0002490)	3.39694922
6	Mitochondrial inheritance (HP:0001427)	3.38576705
7	Progressive macrocephaly (HP:0004481)	3.32515966
8	Increased hepatocellular lipid droplets (HP:0006565)	3.28248066
9	Methylmalonic acidemia (HP:0002912)	3.15143621
10	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.10397069
11	Lipid accumulation in hepatocytes (HP:0006561)	3.06456738
12	Pancreatic cysts (HP:0001737)	3.04303797
13	Progressive inability to walk (HP:0002505)	2.97254694
14	Increased serum lactate (HP:0002151)	2.92403212
15	Hepatocellular necrosis (HP:0001404)	2.82244103
16	Molar tooth sign on MRI (HP:0002419)	2.81851081
17	Abnormality of midbrain morphology (HP:0002418)	2.81851081
18	Colon cancer (HP:0003003)	2.78961153
19	Pancreatic fibrosis (HP:0100732)	2.75961259
20	Nephronophthisis (HP:0000090)	2.73580004
21	Cerebral edema (HP:0002181)	2.70052352
22	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.68974515
23	Hepatic necrosis (HP:0002605)	2.61435409
24	3-Methylglutaconic aciduria (HP:0003535)	2.54314350
25	True hermaphroditism (HP:0010459)	2.53437518
26	Methylmalonic aciduria (HP:0012120)	2.47909239
27	Pendular nystagmus (HP:0012043)	2.38452837
28	Abnormality of the ileum (HP:0001549)	2.33033997
29	Meckel diverticulum (HP:0002245)	2.31815041
30	Lactic acidosis (HP:0003128)	2.31708334
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.30331789
32	Abnormality of alanine metabolism (HP:0010916)	2.30331789
33	Hyperalaninemia (HP:0003348)	2.30331789
34	Renal Fanconi syndrome (HP:0001994)	2.29320036
35	Medial flaring of the eyebrow (HP:0010747)	2.28062907
36	Inability to walk (HP:0002540)	2.27240504
37	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.24257567
38	Congenital stationary night blindness (HP:0007642)	2.22471599
39	Abolished electroretinogram (ERG) (HP:0000550)	2.21516209
40	Abnormality of the renal medulla (HP:0100957)	2.21321241
41	Volvulus (HP:0002580)	2.21306306
42	Hyperglycinemia (HP:0002154)	2.19645223
43	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.16937338
44	Abnormality of serum amino acid levels (HP:0003112)	2.16682109
45	Optic disc pallor (HP:0000543)	2.16024448
46	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.14990506
47	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.14990506
48	Aplasia/hypoplasia of the uterus (HP:0008684)	2.14679091
49	Abnormality of the pons (HP:0007361)	2.13190255
50	Bile duct proliferation (HP:0001408)	2.12501881
51	Abnormal biliary tract physiology (HP:0012439)	2.12501881
52	Abnormality of the renal cortex (HP:0011035)	2.11702745
53	Sensory axonal neuropathy (HP:0003390)	2.08665060
54	Exercise intolerance (HP:0003546)	2.08280522
55	Abnormality of the preputium (HP:0100587)	2.08274911
56	Leukodystrophy (HP:0002415)	2.06959584
57	Hyperglycinuria (HP:0003108)	2.06369690
58	Degeneration of anterior horn cells (HP:0002398)	2.02464971
59	Abnormality of the anterior horn cell (HP:0006802)	2.02464971
60	Sclerocornea (HP:0000647)	2.00937515
61	Abnormality of serine family amino acid metabolism (HP:0010894)	2.00697274
62	Abnormality of glycine metabolism (HP:0010895)	2.00697274
63	Lethargy (HP:0001254)	1.99914269
64	Increased serum pyruvate (HP:0003542)	1.98250866
65	Exertional dyspnea (HP:0002875)	1.97200431
66	Prominent metopic ridge (HP:0005487)	1.96725895
67	Increased intramyocellular lipid droplets (HP:0012240)	1.96421057
68	Abnormality of methionine metabolism (HP:0010901)	1.94557666
69	Type I transferrin isoform profile (HP:0003642)	1.94044378
70	Abnormal protein glycosylation (HP:0012346)	1.92769528
71	Abnormal glycosylation (HP:0012345)	1.92769528
72	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.92769528
73	Abnormal protein N-linked glycosylation (HP:0012347)	1.92769528
74	Abnormality of chromosome stability (HP:0003220)	1.90204220
75	Hypoplasia of the pons (HP:0012110)	1.87873037
76	Abnormality of vitamin B metabolism (HP:0004340)	1.87749739
77	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.86220476
78	Renal cortical cysts (HP:0000803)	1.85979468
79	Absent thumb (HP:0009777)	1.85272862
80	Respiratory failure (HP:0002878)	1.83877997
81	Hypothermia (HP:0002045)	1.81876493
82	Abnormality of the metopic suture (HP:0005556)	1.80272403
83	Ependymoma (HP:0002888)	1.80111303
84	IgG deficiency (HP:0004315)	1.79772521
85	Type II lissencephaly (HP:0007260)	1.79648709
86	Congenital primary aphakia (HP:0007707)	1.78061573
87	Cerebral hypomyelination (HP:0006808)	1.77625171
88	Abnormality of glycolysis (HP:0004366)	1.76965189
89	Multiple enchondromatosis (HP:0005701)	1.74509226
90	Gait imbalance (HP:0002141)	1.74260552
91	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.74255714
92	Tubular atrophy (HP:0000092)	1.73702784
93	Congenital, generalized hypertrichosis (HP:0004540)	1.73162776
94	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.72129451
95	Nephrogenic diabetes insipidus (HP:0009806)	1.71668902
96	Chromsome breakage (HP:0040012)	1.70027844
97	Horseshoe kidney (HP:0000085)	1.68439296
98	Lissencephaly (HP:0001339)	1.66803412
99	Hypoplasia of the uterus (HP:0000013)	1.66427738
100	Small intestinal stenosis (HP:0012848)	1.61585960

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	4.42087055
2	MST4	3.56613025
3	ZAK	3.32201166
4	EIF2AK3	2.78686627
5	SRPK1	2.77316450
6	TRIM28	2.59358765
7	MKNK2	2.55828857
8	MAP4K2	2.42172632
9	BUB1	2.39047884
10	MKNK1	2.22673537
11	NUAK1	2.19705715
12	NEK1	2.18417962
13	VRK2	2.17630641
14	TNIK	2.08808132
15	CDC7	2.07910794
16	PLK3	2.03655634
17	DYRK3	1.95639806
18	EIF2AK1	1.88841337
19	WNK3	1.81628023
20	VRK1	1.80956016
21	TLK1	1.72199658
22	PLK4	1.71866001
23	STK16	1.70915017
24	BMPR1B	1.65799294
25	BCR	1.56798265
26	WNK4	1.47723992
27	FRK	1.46008374
28	TTK	1.41758302
29	GRK1	1.37567306
30	MAP3K4	1.33008552
31	NME1	1.30925540
32	BCKDK	1.29152742
33	ADRBK2	1.28396017
34	OXSR1	1.27268145
35	PLK1	1.24564997
36	TAF1	1.24407702
37	RPS6KA4	1.17925403
38	PINK1	1.17602627
39	TIE1	1.16398323
40	CSNK1G3	1.15433745
41	CSNK1G1	1.12921265
42	STK39	1.06397632
43	CSNK1G2	1.04910066
44	CSNK1A1L	1.02435733
45	ATR	1.02134143
46	ALK	1.01104340
47	MAP2K7	0.96774156
48	ERBB3	0.93447949
49	DYRK2	0.91408807
50	PBK	0.91279103
51	PLK2	0.89031553
52	EIF2AK2	0.86192123
53	TXK	0.85493519
54	MAPKAPK3	0.83689498
55	AURKB	0.80910891
56	PNCK	0.80864168
57	PASK	0.78131551
58	RPS6KA5	0.77607717
59	MAPKAPK5	0.71936465
60	CHEK2	0.71843178
61	WEE1	0.71514553
62	CDK19	0.64542876
63	ATM	0.64259824
64	STK38L	0.63990747
65	CHEK1	0.63595473
66	INSRR	0.63203152
67	MAPK13	0.63115678
68	CSNK2A2	0.62330327
69	CSNK1E	0.61980561
70	TAOK3	0.60779011
71	CSNK2A1	0.55690322
72	ACVR1B	0.55451793
73	CASK	0.55006412
74	PHKG1	0.52635757
75	PHKG2	0.52635757
76	PAK3	0.49494622
77	TEC	0.48637438
78	DAPK1	0.47643474
79	PRKCE	0.46367944
80	PRKCG	0.46111519
81	BRSK2	0.45226244
82	CSNK1A1	0.41045628
83	RPS6KB2	0.40771141
84	MINK1	0.39742614
85	MAP3K12	0.38345274
86	BRD4	0.37730424
87	AURKA	0.36599504
88	PRKDC	0.34730858
89	NEK2	0.29066804
90	TGFBR1	0.28781976
91	PRKCI	0.28222887
92	CDK1	0.28131598
93	STK10	0.26878581
94	SIK3	0.26742358
95	PRKACB	0.26288836
96	LIMK1	0.26260461
97	CSNK1D	0.26240735
98	CDK2	0.25729087
99	IKBKB	0.24005578
100	MAP2K6	0.23048089

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.96949532
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.46232960
3	Protein export_Homo sapiens_hsa03060	3.37195899
4	RNA polymerase_Homo sapiens_hsa03020	2.89999141
5	Basal transcription factors_Homo sapiens_hsa03022	2.55375596
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.55003912
7	One carbon pool by folate_Homo sapiens_hsa00670	2.54643015
8	RNA degradation_Homo sapiens_hsa03018	2.31301945
9	Mismatch repair_Homo sapiens_hsa03430	2.27177177
10	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.23655298
11	Spliceosome_Homo sapiens_hsa03040	2.22718672
12	Non-homologous end-joining_Homo sapiens_hsa03450	2.22419901
13	Parkinsons disease_Homo sapiens_hsa05012	2.20998355
14	RNA transport_Homo sapiens_hsa03013	2.19261407
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.07628329
16	Homologous recombination_Homo sapiens_hsa03440	2.06105475
17	DNA replication_Homo sapiens_hsa03030	1.98582145
18	Propanoate metabolism_Homo sapiens_hsa00640	1.89091703
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84168895
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.72224783
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.70967826
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.57371989
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.56556358
24	Ribosome_Homo sapiens_hsa03010	1.56113383
25	Base excision repair_Homo sapiens_hsa03410	1.55814284
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.55045464
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.53050438
28	Huntingtons disease_Homo sapiens_hsa05016	1.50523983
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.48294328
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.46952060
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.34940199
32	Phototransduction_Homo sapiens_hsa04744	1.33389475
33	Asthma_Homo sapiens_hsa05310	1.31995221
34	Purine metabolism_Homo sapiens_hsa00230	1.27100909
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.25264459
36	Alzheimers disease_Homo sapiens_hsa05010	1.22576393
37	Butanoate metabolism_Homo sapiens_hsa00650	1.22295083
38	Sulfur metabolism_Homo sapiens_hsa00920	1.21841364
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07775652
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06362928
41	mRNA surveillance pathway_Homo sapiens_hsa03015	1.03044528
42	Type I diabetes mellitus_Homo sapiens_hsa04940	1.02763570
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.02443668
44	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.97626365
45	Pyruvate metabolism_Homo sapiens_hsa00620	0.95133599
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.90901195
47	Allograft rejection_Homo sapiens_hsa05330	0.90353416
48	Linoleic acid metabolism_Homo sapiens_hsa00591	0.85738331
49	Fatty acid elongation_Homo sapiens_hsa00062	0.80606240
50	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.79138281
51	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.75462633
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75223315
53	Olfactory transduction_Homo sapiens_hsa04740	0.74902822
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.74603609
55	Peroxisome_Homo sapiens_hsa04146	0.73416331
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.71854385
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.71675155
58	Regulation of autophagy_Homo sapiens_hsa04140	0.71559882
59	Metabolic pathways_Homo sapiens_hsa01100	0.67965137
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.67584636
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.65860289
62	Cell cycle_Homo sapiens_hsa04110	0.64989773
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64586482
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63016373
65	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58872185
66	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57702183
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.57684610
68	Nicotine addiction_Homo sapiens_hsa05033	0.56860233
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54980657
70	Glutathione metabolism_Homo sapiens_hsa00480	0.54191188
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51876280
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.51388694
73	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.50957578
74	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.50440942
75	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.50046765
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49122333
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.47001912
78	Primary immunodeficiency_Homo sapiens_hsa05340	0.45789828
79	Folate biosynthesis_Homo sapiens_hsa00790	0.45588348
80	Graft-versus-host disease_Homo sapiens_hsa05332	0.45231973
81	Carbon metabolism_Homo sapiens_hsa01200	0.42799902
82	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42544171
83	p53 signaling pathway_Homo sapiens_hsa04115	0.40976228
84	Caffeine metabolism_Homo sapiens_hsa00232	0.40651850
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39122133
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.38852323
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37681475
88	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.36986089
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35963024
90	Oocyte meiosis_Homo sapiens_hsa04114	0.35471523
91	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.35208358
92	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.32432295
93	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.32256820
94	Sulfur relay system_Homo sapiens_hsa04122	0.30876078
95	Rheumatoid arthritis_Homo sapiens_hsa05323	0.29385687
96	Taste transduction_Homo sapiens_hsa04742	0.28497412
97	Herpes simplex infection_Homo sapiens_hsa05168	0.28213961
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.27204162
99	Alcoholism_Homo sapiens_hsa05034	0.25610570
100	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.25600681

HSP90AB2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »