

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.88490867 |
| 2 | proteasome assembly (GO:0043248) | 4.95275607 |
| 3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.78813388 |
| 4 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.64825771 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.56949047 |
| 6 | ATP synthesis coupled proton transport (GO:0015986) | 4.56949047 |
| 7 | protein neddylation (GO:0045116) | 4.42161312 |
| 8 | protein complex biogenesis (GO:0070271) | 4.40422444 |
| 9 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.37513990 |
| 10 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.35955335 |
| 11 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.19810049 |
| 12 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.19810049 |
| 13 | NADH dehydrogenase complex assembly (GO:0010257) | 4.19810049 |
| 14 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.15177210 |
| 15 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.96284732 |
| 16 | chaperone-mediated protein transport (GO:0072321) | 3.95234613 |
| 17 | rRNA modification (GO:0000154) | 3.94700218 |
| 18 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.87836778 |
| 19 | respiratory chain complex IV assembly (GO:0008535) | 3.82284782 |
| 20 | termination of RNA polymerase III transcription (GO:0006386) | 3.78340613 |
| 21 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.78340613 |
| 22 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.72470555 |
| 23 | electron transport chain (GO:0022900) | 3.71443903 |
| 24 | respiratory electron transport chain (GO:0022904) | 3.70346670 |
| 25 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.59233005 |
| 26 | cullin deneddylation (GO:0010388) | 3.55032048 |
| 27 | maturation of 5.8S rRNA (GO:0000460) | 3.53413211 |
| 28 | cytochrome complex assembly (GO:0017004) | 3.51962573 |
| 29 | mannosylation (GO:0097502) | 3.45338005 |
| 30 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.44564854 |
| 31 | protein deneddylation (GO:0000338) | 3.44084058 |
| 32 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.44052432 |
| 33 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.42306240 |
| 34 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.37086122 |
| 35 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.37086122 |
| 36 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.37086122 |
| 37 | rRNA methylation (GO:0031167) | 3.33539206 |
| 38 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.32997433 |
| 39 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.32997433 |
| 40 | platelet dense granule organization (GO:0060155) | 3.30132748 |
| 41 | pseudouridine synthesis (GO:0001522) | 3.29508445 |
| 42 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.29154946 |
| 43 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.25374830 |
| 44 | protein-cofactor linkage (GO:0018065) | 3.24809185 |
| 45 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.22721157 |
| 46 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.21004457 |
| 47 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.21004457 |
| 48 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.20893905 |
| 49 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.20893905 |
| 50 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.19918387 |
| 51 | negative regulation of ligase activity (GO:0051352) | 3.19918387 |
| 52 | cytidine deamination (GO:0009972) | 3.15317574 |
| 53 | cytidine metabolic process (GO:0046087) | 3.15317574 |
| 54 | cytidine catabolic process (GO:0006216) | 3.15317574 |
| 55 | GTP biosynthetic process (GO:0006183) | 3.09543709 |
| 56 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.98163983 |
| 57 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.97693866 |
| 58 | peptidyl-histidine modification (GO:0018202) | 2.97310140 |
| 59 | negative regulation of telomere maintenance (GO:0032205) | 2.95887384 |
| 60 | ribosome assembly (GO:0042255) | 2.94740430 |
| 61 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.94635038 |
| 62 | tRNA processing (GO:0008033) | 2.92861832 |
| 63 | DNA damage response, detection of DNA damage (GO:0042769) | 2.92209206 |
| 64 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.89318105 |
| 65 | positive regulation of ligase activity (GO:0051351) | 2.86655783 |
| 66 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.85547372 |
| 67 | protein targeting to mitochondrion (GO:0006626) | 2.85484614 |
| 68 | DNA double-strand break processing (GO:0000729) | 2.84961939 |
| 69 | inner mitochondrial membrane organization (GO:0007007) | 2.84538829 |
| 70 | axoneme assembly (GO:0035082) | 2.84136939 |
| 71 | behavioral response to nicotine (GO:0035095) | 2.82041579 |
| 72 | establishment of protein localization to mitochondrion (GO:0072655) | 2.81938968 |
| 73 | hydrogen ion transmembrane transport (GO:1902600) | 2.81708709 |
| 74 | histone mRNA metabolic process (GO:0008334) | 2.79214210 |
| 75 | ATP biosynthetic process (GO:0006754) | 2.77969582 |
| 76 | GPI anchor metabolic process (GO:0006505) | 2.77647435 |
| 77 | retinal cone cell development (GO:0046549) | 2.77559909 |
| 78 | ubiquinone biosynthetic process (GO:0006744) | 2.75042872 |
| 79 | response to pheromone (GO:0019236) | 2.74737674 |
| 80 | ubiquinone metabolic process (GO:0006743) | 2.74301890 |
| 81 | proton transport (GO:0015992) | 2.71434840 |
| 82 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.71259982 |
| 83 | protein localization to mitochondrion (GO:0070585) | 2.71069537 |
| 84 | base-excision repair, AP site formation (GO:0006285) | 2.70667278 |
| 85 | regulation of cellular amine metabolic process (GO:0033238) | 2.69653589 |
| 86 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.69534884 |
| 87 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.68837428 |
| 88 | isotype switching (GO:0045190) | 2.68837428 |
| 89 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.68837428 |
| 90 | spliceosomal snRNP assembly (GO:0000387) | 2.67955941 |
| 91 | hydrogen transport (GO:0006818) | 2.67760593 |
| 92 | intracellular protein transmembrane import (GO:0044743) | 2.65810935 |
| 93 | rRNA processing (GO:0006364) | 2.64860683 |
| 94 | regulation of mitochondrial translation (GO:0070129) | 2.62425638 |
| 95 | rRNA metabolic process (GO:0016072) | 2.61642740 |
| 96 | positive regulation of cell cycle arrest (GO:0071158) | 2.59867210 |
| 97 | tRNA metabolic process (GO:0006399) | 2.59707415 |
| 98 | fucose catabolic process (GO:0019317) | 2.57635738 |
| 99 | L-fucose metabolic process (GO:0042354) | 2.57635738 |
| 100 | L-fucose catabolic process (GO:0042355) | 2.57635738 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.47026188 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.23062778 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.64526192 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.22526679 |
| 5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.20383865 |
| 6 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.98929395 |
| 7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.98082193 |
| 8 | VDR_22108803_ChIP-Seq_LS180_Human | 2.96355858 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.94820267 |
| 10 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.76160467 |
| 11 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.71977595 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.60894572 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.59735750 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.46196275 |
| 15 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.23301201 |
| 16 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.16186611 |
| 17 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.14311805 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.13689719 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.13237728 |
| 20 | EWS_26573619_Chip-Seq_HEK293_Human | 2.09050707 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.07939185 |
| 22 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.07523100 |
| 23 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.05408395 |
| 24 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.97690907 |
| 25 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.97189644 |
| 26 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.80471784 |
| 27 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.75160205 |
| 28 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.74990233 |
| 29 | FUS_26573619_Chip-Seq_HEK293_Human | 1.70030991 |
| 30 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.65459540 |
| 31 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.62499453 |
| 32 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.58962679 |
| 33 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.56772981 |
| 34 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.54576912 |
| 35 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.53869030 |
| 36 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.50805903 |
| 37 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.50546587 |
| 38 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.48390901 |
| 39 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.47792574 |
| 40 | P300_19829295_ChIP-Seq_ESCs_Human | 1.46394217 |
| 41 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.42052326 |
| 42 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.39860238 |
| 43 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.37622500 |
| 44 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.32582616 |
| 45 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.32582616 |
| 46 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.30892330 |
| 47 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.30664372 |
| 48 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.30386033 |
| 49 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.30310482 |
| 50 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.28990333 |
| 51 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.28104458 |
| 52 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.27509673 |
| 53 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.25449525 |
| 54 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.25415649 |
| 55 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.25264709 |
| 56 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.24292436 |
| 57 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.24215339 |
| 58 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.24215339 |
| 59 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.21239803 |
| 60 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.17774179 |
| 61 | AR_20517297_ChIP-Seq_VCAP_Human | 1.17456578 |
| 62 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.15970969 |
| 63 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.14259387 |
| 64 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.13800526 |
| 65 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.12948269 |
| 66 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.12094697 |
| 67 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.12094697 |
| 68 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.10686805 |
| 69 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.09323183 |
| 70 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.08615690 |
| 71 | NCOR_22424771_ChIP-Seq_293T_Human | 1.03554346 |
| 72 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.03339479 |
| 73 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.03326367 |
| 74 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.02781621 |
| 75 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.02727758 |
| 76 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.02698583 |
| 77 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.02529811 |
| 78 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.02053771 |
| 79 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.98831598 |
| 80 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.98130298 |
| 81 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.97651095 |
| 82 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.96662110 |
| 83 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96400763 |
| 84 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.96152774 |
| 85 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.95847900 |
| 86 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.95644898 |
| 87 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.92587644 |
| 88 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.92334356 |
| 89 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.91872729 |
| 90 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.91755421 |
| 91 | GATA3_26560356_Chip-Seq_TH2_Human | 0.91167208 |
| 92 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.90958897 |
| 93 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.90840526 |
| 94 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.90646729 |
| 95 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.89469075 |
| 96 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.88594326 |
| 97 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.87033892 |
| 98 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.86771357 |
| 99 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.86619860 |
| 100 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.85051231 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002102_abnormal_ear_morphology | 2.91496396 |
| 2 | MP0008877_abnormal_DNA_methylation | 2.85696424 |
| 3 | MP0003195_calcinosis | 2.75468763 |
| 4 | MP0006072_abnormal_retinal_apoptosis | 2.65448922 |
| 5 | MP0008058_abnormal_DNA_repair | 2.28551983 |
| 6 | MP0003786_premature_aging | 2.24238678 |
| 7 | MP0000372_irregular_coat_pigmentation | 2.19648521 |
| 8 | MP0005645_abnormal_hypothalamus_physiol | 2.17177143 |
| 9 | MP0005084_abnormal_gallbladder_morpholo | 2.08657712 |
| 10 | MP0003011_delayed_dark_adaptation | 2.06897487 |
| 11 | MP0002837_dystrophic_cardiac_calcinosis | 2.04658916 |
| 12 | MP0008872_abnormal_physiological_respon | 2.03671621 |
| 13 | MP0004147_increased_porphyrin_level | 2.02403684 |
| 14 | MP0008875_abnormal_xenobiotic_pharmacok | 2.02213945 |
| 15 | MP0005646_abnormal_pituitary_gland | 2.01245427 |
| 16 | MP0005551_abnormal_eye_electrophysiolog | 1.95252362 |
| 17 | MP0001529_abnormal_vocalization | 1.93166795 |
| 18 | MP0005671_abnormal_response_to | 1.91666270 |
| 19 | MP0006292_abnormal_olfactory_placode | 1.90518697 |
| 20 | MP0005253_abnormal_eye_physiology | 1.89507316 |
| 21 | MP0001968_abnormal_touch/_nociception | 1.86102210 |
| 22 | MP0003718_maternal_effect | 1.85687400 |
| 23 | MP0002163_abnormal_gland_morphology | 1.83842904 |
| 24 | MP0002736_abnormal_nociception_after | 1.78786802 |
| 25 | MP0003787_abnormal_imprinting | 1.78761387 |
| 26 | MP0001984_abnormal_olfaction | 1.65543313 |
| 27 | MP0004145_abnormal_muscle_electrophysio | 1.65361417 |
| 28 | MP0003806_abnormal_nucleotide_metabolis | 1.63556260 |
| 29 | MP0002876_abnormal_thyroid_physiology | 1.62459094 |
| 30 | MP0005379_endocrine/exocrine_gland_phen | 1.57074896 |
| 31 | MP0002277_abnormal_respiratory_mucosa | 1.56762782 |
| 32 | MP0003646_muscle_fatigue | 1.55409609 |
| 33 | MP0005075_abnormal_melanosome_morpholog | 1.53652207 |
| 34 | MP0002138_abnormal_hepatobiliary_system | 1.53524266 |
| 35 | MP0006276_abnormal_autonomic_nervous | 1.51703247 |
| 36 | MP0006036_abnormal_mitochondrial_physio | 1.45455533 |
| 37 | MP0004142_abnormal_muscle_tone | 1.43460328 |
| 38 | MP0002160_abnormal_reproductive_system | 1.40946199 |
| 39 | MP0001905_abnormal_dopamine_level | 1.37336630 |
| 40 | MP0008995_early_reproductive_senescence | 1.37025480 |
| 41 | MP0001986_abnormal_taste_sensitivity | 1.36476056 |
| 42 | MP0005389_reproductive_system_phenotype | 1.33480741 |
| 43 | MP0006035_abnormal_mitochondrial_morpho | 1.32067460 |
| 44 | MP0003693_abnormal_embryo_hatching | 1.27066601 |
| 45 | MP0003880_abnormal_central_pattern | 1.26171497 |
| 46 | MP0001835_abnormal_antigen_presentation | 1.23208062 |
| 47 | MP0010094_abnormal_chromosome_stability | 1.22657187 |
| 48 | MP0009745_abnormal_behavioral_response | 1.21159896 |
| 49 | MP0000631_abnormal_neuroendocrine_gland | 1.19460726 |
| 50 | MP0002272_abnormal_nervous_system | 1.18746257 |
| 51 | MP0009046_muscle_twitch | 1.18486103 |
| 52 | MP0003121_genomic_imprinting | 1.18080081 |
| 53 | MP0003186_abnormal_redox_activity | 1.17449679 |
| 54 | MP0005332_abnormal_amino_acid | 1.16259936 |
| 55 | MP0009697_abnormal_copulation | 1.14402043 |
| 56 | MP0008007_abnormal_cellular_replicative | 1.12244272 |
| 57 | MP0003567_abnormal_fetal_cardiomyocyte | 1.09259671 |
| 58 | MP0004957_abnormal_blastocyst_morpholog | 1.08242698 |
| 59 | MP0002638_abnormal_pupillary_reflex | 1.04655735 |
| 60 | MP0001919_abnormal_reproductive_system | 1.04281817 |
| 61 | MP0002938_white_spotting | 1.01811378 |
| 62 | MP0002751_abnormal_autonomic_nervous | 1.01711284 |
| 63 | MP0005410_abnormal_fertilization | 1.01320416 |
| 64 | MP0001188_hyperpigmentation | 1.00500801 |
| 65 | MP0001501_abnormal_sleep_pattern | 0.97609037 |
| 66 | MP0001764_abnormal_homeostasis | 0.96492856 |
| 67 | MP0005636_abnormal_mineral_homeostasis | 0.96332043 |
| 68 | MP0004885_abnormal_endolymph | 0.95442619 |
| 69 | MP0001486_abnormal_startle_reflex | 0.94264380 |
| 70 | MP0008789_abnormal_olfactory_epithelium | 0.92623306 |
| 71 | MP0010386_abnormal_urinary_bladder | 0.90487257 |
| 72 | MP0004043_abnormal_pH_regulation | 0.89279590 |
| 73 | MP0009785_altered_susceptibility_to | 0.87373797 |
| 74 | MP0001873_stomach_inflammation | 0.86493544 |
| 75 | MP0001929_abnormal_gametogenesis | 0.86238050 |
| 76 | MP0002693_abnormal_pancreas_physiology | 0.86085127 |
| 77 | MP0002653_abnormal_ependyma_morphology | 0.86045359 |
| 78 | MP0003122_maternal_imprinting | 0.83889488 |
| 79 | MP0002210_abnormal_sex_determination | 0.82670820 |
| 80 | MP0004215_abnormal_myocardial_fiber | 0.81026753 |
| 81 | MP0005377_hearing/vestibular/ear_phenot | 0.79894086 |
| 82 | MP0003878_abnormal_ear_physiology | 0.79894086 |
| 83 | MP0001293_anophthalmia | 0.79481982 |
| 84 | MP0002733_abnormal_thermal_nociception | 0.79018690 |
| 85 | MP0004742_abnormal_vestibular_system | 0.78674920 |
| 86 | MP0000653_abnormal_sex_gland | 0.78207399 |
| 87 | MP0002006_tumorigenesis | 0.77774727 |
| 88 | MP0001485_abnormal_pinna_reflex | 0.77353318 |
| 89 | MP0002557_abnormal_social/conspecific_i | 0.77027427 |
| 90 | MP0001119_abnormal_female_reproductive | 0.76044484 |
| 91 | MP0005085_abnormal_gallbladder_physiolo | 0.75936052 |
| 92 | MP0003137_abnormal_impulse_conducting | 0.74936273 |
| 93 | MP0005167_abnormal_blood-brain_barrier | 0.73850225 |
| 94 | MP0009333_abnormal_splenocyte_physiolog | 0.72804642 |
| 95 | MP0001970_abnormal_pain_threshold | 0.71938026 |
| 96 | MP0002234_abnormal_pharynx_morphology | 0.70795707 |
| 97 | MP0002148_abnormal_hypersensitivity_rea | 0.69710140 |
| 98 | MP0002909_abnormal_adrenal_gland | 0.69391506 |
| 99 | MP0002254_reproductive_system_inflammat | 0.69282062 |
| 100 | MP0003698_abnormal_male_reproductive | 0.68616334 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.87501905 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.30636294 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.27141688 |
| 4 | Progressive macrocephaly (HP:0004481) | 4.23181028 |
| 5 | Acute encephalopathy (HP:0006846) | 4.22678503 |
| 6 | Increased CSF lactate (HP:0002490) | 4.07587787 |
| 7 | Hepatocellular necrosis (HP:0001404) | 3.83301020 |
| 8 | Hepatic necrosis (HP:0002605) | 3.54885720 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 3.48620057 |
| 10 | Pancreatic cysts (HP:0001737) | 3.34928468 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 3.31017841 |
| 12 | 3-Methylglutaconic aciduria (HP:0003535) | 3.19682760 |
| 13 | Cerebral edema (HP:0002181) | 3.14055741 |
| 14 | Pancreatic fibrosis (HP:0100732) | 2.99654091 |
| 15 | Congenital stationary night blindness (HP:0007642) | 2.98402936 |
| 16 | Molar tooth sign on MRI (HP:0002419) | 2.95698633 |
| 17 | Abnormality of midbrain morphology (HP:0002418) | 2.95698633 |
| 18 | Methylmalonic acidemia (HP:0002912) | 2.91691907 |
| 19 | Renal Fanconi syndrome (HP:0001994) | 2.88310767 |
| 20 | Increased serum lactate (HP:0002151) | 2.84304434 |
| 21 | True hermaphroditism (HP:0010459) | 2.78897566 |
| 22 | Optic disc pallor (HP:0000543) | 2.77480114 |
| 23 | Nephronophthisis (HP:0000090) | 2.69971452 |
| 24 | Lactic acidosis (HP:0003128) | 2.58334005 |
| 25 | Hyperglycinemia (HP:0002154) | 2.57538116 |
| 26 | Abolished electroretinogram (ERG) (HP:0000550) | 2.57024835 |
| 27 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.53880879 |
| 28 | Methylmalonic aciduria (HP:0012120) | 2.52254637 |
| 29 | Respiratory failure (HP:0002878) | 2.47475437 |
| 30 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.43192803 |
| 31 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.41136446 |
| 32 | Abnormality of the renal cortex (HP:0011035) | 2.38100793 |
| 33 | Type II lissencephaly (HP:0007260) | 2.36747788 |
| 34 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.36438678 |
| 35 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.32335199 |
| 36 | Lethargy (HP:0001254) | 2.31588070 |
| 37 | Abnormality of the labia minora (HP:0012880) | 2.30234567 |
| 38 | Abnormality of the renal medulla (HP:0100957) | 2.29693356 |
| 39 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.27993278 |
| 40 | Absent/shortened dynein arms (HP:0200106) | 2.27993278 |
| 41 | Exertional dyspnea (HP:0002875) | 2.26610737 |
| 42 | Leukodystrophy (HP:0002415) | 2.25750844 |
| 43 | Aplastic anemia (HP:0001915) | 2.25058777 |
| 44 | Exercise intolerance (HP:0003546) | 2.24704322 |
| 45 | Increased intramyocellular lipid droplets (HP:0012240) | 2.24225089 |
| 46 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.24193842 |
| 47 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.24193842 |
| 48 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.23359300 |
| 49 | Type I transferrin isoform profile (HP:0003642) | 2.23296801 |
| 50 | Renal cortical cysts (HP:0000803) | 2.22707692 |
| 51 | Pendular nystagmus (HP:0012043) | 2.20104862 |
| 52 | IgG deficiency (HP:0004315) | 2.18526113 |
| 53 | Hypoproteinemia (HP:0003075) | 2.16367252 |
| 54 | Congenital, generalized hypertrichosis (HP:0004540) | 2.12776182 |
| 55 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.11998788 |
| 56 | Abnormality of alanine metabolism (HP:0010916) | 2.11998788 |
| 57 | Hyperalaninemia (HP:0003348) | 2.11998788 |
| 58 | Hypothermia (HP:0002045) | 2.10528055 |
| 59 | Attenuation of retinal blood vessels (HP:0007843) | 2.10204570 |
| 60 | Decreased central vision (HP:0007663) | 2.09463435 |
| 61 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.07849154 |
| 62 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.07849154 |
| 63 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.05183422 |
| 64 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.05183422 |
| 65 | Abnormal protein glycosylation (HP:0012346) | 2.05183422 |
| 66 | Abnormal glycosylation (HP:0012345) | 2.05183422 |
| 67 | Medial flaring of the eyebrow (HP:0010747) | 2.03036337 |
| 68 | Abnormal drinking behavior (HP:0030082) | 2.02930483 |
| 69 | Polydipsia (HP:0001959) | 2.02930483 |
| 70 | Constricted visual fields (HP:0001133) | 2.02104249 |
| 71 | Stomatitis (HP:0010280) | 2.02043460 |
| 72 | CNS demyelination (HP:0007305) | 1.99435994 |
| 73 | Abnormality of serum amino acid levels (HP:0003112) | 1.97971794 |
| 74 | Chronic hepatic failure (HP:0100626) | 1.97750574 |
| 75 | Glycosuria (HP:0003076) | 1.97292197 |
| 76 | Abnormality of urine glucose concentration (HP:0011016) | 1.97292197 |
| 77 | Sclerocornea (HP:0000647) | 1.97072430 |
| 78 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.92407904 |
| 79 | Pancytopenia (HP:0001876) | 1.85734955 |
| 80 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.84480790 |
| 81 | Abnormality of glycine metabolism (HP:0010895) | 1.84480790 |
| 82 | Abnormality of the pons (HP:0007361) | 1.83577481 |
| 83 | Hypomagnesemia (HP:0002917) | 1.83105679 |
| 84 | Colon cancer (HP:0003003) | 1.82387827 |
| 85 | Abnormality of vitamin B metabolism (HP:0004340) | 1.81257326 |
| 86 | Hypoplasia of the uterus (HP:0000013) | 1.79944009 |
| 87 | Increased muscle lipid content (HP:0009058) | 1.79632620 |
| 88 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.79528744 |
| 89 | Oral leukoplakia (HP:0002745) | 1.77758064 |
| 90 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.77169795 |
| 91 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.76147401 |
| 92 | Hyperglycinuria (HP:0003108) | 1.76059182 |
| 93 | Ketosis (HP:0001946) | 1.74751455 |
| 94 | Cystic liver disease (HP:0006706) | 1.71833122 |
| 95 | Generalized aminoaciduria (HP:0002909) | 1.71494313 |
| 96 | Type 2 muscle fiber atrophy (HP:0003554) | 1.70546016 |
| 97 | Hypoplasia of the pons (HP:0012110) | 1.70178110 |
| 98 | Abnormality of renal resorption (HP:0011038) | 1.70028081 |
| 99 | Ketoacidosis (HP:0001993) | 1.69738796 |
| 100 | Large for gestational age (HP:0001520) | 1.67962753 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K2 | 3.20973714 |
| 2 | VRK2 | 3.18296944 |
| 3 | TSSK6 | 2.99591217 |
| 4 | MST4 | 2.88212359 |
| 5 | ZAK | 2.69726842 |
| 6 | FRK | 2.59035350 |
| 7 | TXK | 2.58376058 |
| 8 | EIF2AK3 | 2.45450825 |
| 9 | NUAK1 | 2.41490531 |
| 10 | BUB1 | 2.16050405 |
| 11 | BCKDK | 2.13739812 |
| 12 | GRK1 | 2.09124015 |
| 13 | ADRBK2 | 2.01803138 |
| 14 | TLK1 | 1.98595499 |
| 15 | TRIM28 | 1.91134294 |
| 16 | VRK1 | 1.90698872 |
| 17 | STK16 | 1.85731609 |
| 18 | SRPK1 | 1.79144397 |
| 19 | TAOK3 | 1.70778608 |
| 20 | WNK3 | 1.64514877 |
| 21 | PLK3 | 1.61292860 |
| 22 | EIF2AK1 | 1.57194672 |
| 23 | BCR | 1.48924267 |
| 24 | PINK1 | 1.44122791 |
| 25 | WNK4 | 1.43115365 |
| 26 | PBK | 1.38245602 |
| 27 | NME1 | 1.35357167 |
| 28 | NEK1 | 1.31895073 |
| 29 | BMPR1B | 1.27931355 |
| 30 | TIE1 | 1.26678091 |
| 31 | OXSR1 | 1.25670552 |
| 32 | MAP3K12 | 1.23867796 |
| 33 | DYRK2 | 1.22605420 |
| 34 | CSNK1G3 | 1.21680902 |
| 35 | KDR | 1.18605041 |
| 36 | CSNK1G2 | 1.15831866 |
| 37 | CSNK1G1 | 1.10985504 |
| 38 | INSRR | 1.08254754 |
| 39 | STK39 | 1.08006820 |
| 40 | PLK2 | 1.07095309 |
| 41 | CSNK1A1L | 1.02751477 |
| 42 | ERBB3 | 1.01678240 |
| 43 | MKNK1 | 1.01564941 |
| 44 | MKNK2 | 0.99900536 |
| 45 | TEC | 0.99764058 |
| 46 | TESK2 | 0.94865329 |
| 47 | PHKG2 | 0.94305645 |
| 48 | PHKG1 | 0.94305645 |
| 49 | TNIK | 0.94253937 |
| 50 | MAPK13 | 0.90819479 |
| 51 | MAP2K7 | 0.85757738 |
| 52 | MAP3K4 | 0.84098495 |
| 53 | TAF1 | 0.79279944 |
| 54 | PLK4 | 0.78842042 |
| 55 | RPS6KA5 | 0.78640688 |
| 56 | FLT3 | 0.77940853 |
| 57 | DAPK1 | 0.76887939 |
| 58 | CDC7 | 0.75421454 |
| 59 | MUSK | 0.72672831 |
| 60 | EIF2AK2 | 0.72056653 |
| 61 | PLK1 | 0.71355145 |
| 62 | PASK | 0.71014269 |
| 63 | ITK | 0.69429899 |
| 64 | IKBKB | 0.67684332 |
| 65 | PRKCE | 0.66133868 |
| 66 | ATR | 0.61809719 |
| 67 | MAPKAPK5 | 0.61626741 |
| 68 | KIT | 0.59060039 |
| 69 | WEE1 | 0.59005410 |
| 70 | PRKCQ | 0.56841540 |
| 71 | PRKCG | 0.56333798 |
| 72 | DAPK2 | 0.51798261 |
| 73 | CSNK2A1 | 0.51579909 |
| 74 | CASK | 0.48560455 |
| 75 | PAK3 | 0.47687171 |
| 76 | CSNK1A1 | 0.46819297 |
| 77 | MAP2K6 | 0.46680444 |
| 78 | PDK2 | 0.44796652 |
| 79 | CSNK2A2 | 0.43835578 |
| 80 | IKBKE | 0.42078197 |
| 81 | RPS6KA4 | 0.41719390 |
| 82 | MAPKAPK3 | 0.41503827 |
| 83 | ADRBK1 | 0.41037497 |
| 84 | OBSCN | 0.39334784 |
| 85 | ATM | 0.37741866 |
| 86 | LIMK1 | 0.36907843 |
| 87 | PRKACA | 0.36516067 |
| 88 | CAMK2A | 0.35402607 |
| 89 | AURKB | 0.34994063 |
| 90 | AURKA | 0.33859462 |
| 91 | MAP4K1 | 0.33550136 |
| 92 | PRKCA | 0.31680203 |
| 93 | CHEK2 | 0.30928076 |
| 94 | CCNB1 | 0.30666702 |
| 95 | IGF1R | 0.30436654 |
| 96 | MYLK | 0.30405929 |
| 97 | ALK | 0.30228595 |
| 98 | FES | 0.29757359 |
| 99 | MINK1 | 0.28389829 |
| 100 | GRK7 | 0.27421414 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.48151729 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.64180734 |
| 3 | Protein export_Homo sapiens_hsa03060 | 3.28208447 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.94700621 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.70286136 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.44587892 |
| 7 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.17675810 |
| 8 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.07463332 |
| 9 | Huntingtons disease_Homo sapiens_hsa05016 | 2.00809155 |
| 10 | Alzheimers disease_Homo sapiens_hsa05010 | 1.87959250 |
| 11 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.84269368 |
| 12 | Phototransduction_Homo sapiens_hsa04744 | 1.81986638 |
| 13 | RNA degradation_Homo sapiens_hsa03018 | 1.79982884 |
| 14 | Ribosome_Homo sapiens_hsa03010 | 1.79606350 |
| 15 | Basal transcription factors_Homo sapiens_hsa03022 | 1.78413894 |
| 16 | Homologous recombination_Homo sapiens_hsa03440 | 1.70108972 |
| 17 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.56977442 |
| 18 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.54887539 |
| 19 | Asthma_Homo sapiens_hsa05310 | 1.52850578 |
| 20 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.51187582 |
| 21 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.49468227 |
| 22 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.48581500 |
| 23 | Mismatch repair_Homo sapiens_hsa03430 | 1.44000791 |
| 24 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.41404718 |
| 25 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.41389378 |
| 26 | Spliceosome_Homo sapiens_hsa03040 | 1.38172715 |
| 27 | Allograft rejection_Homo sapiens_hsa05330 | 1.35795042 |
| 28 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.33692031 |
| 29 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.32445640 |
| 30 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.32257764 |
| 31 | RNA transport_Homo sapiens_hsa03013 | 1.32108635 |
| 32 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.31824469 |
| 33 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.29524667 |
| 34 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.27611478 |
| 35 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.26709842 |
| 36 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.25147527 |
| 37 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.23496231 |
| 38 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.22602582 |
| 39 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.18681628 |
| 40 | DNA replication_Homo sapiens_hsa03030 | 1.15317203 |
| 41 | Purine metabolism_Homo sapiens_hsa00230 | 1.12628710 |
| 42 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.09574477 |
| 43 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.09332566 |
| 44 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.08948922 |
| 45 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.08550428 |
| 46 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.08117246 |
| 47 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.06037814 |
| 48 | Peroxisome_Homo sapiens_hsa04146 | 1.05865261 |
| 49 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.02515680 |
| 50 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.02258076 |
| 51 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.01326408 |
| 52 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.93865684 |
| 53 | Base excision repair_Homo sapiens_hsa03410 | 0.92306920 |
| 54 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.88136000 |
| 55 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.88026361 |
| 56 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.87191156 |
| 57 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.85219579 |
| 58 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.81788841 |
| 59 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.81468540 |
| 60 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.79701437 |
| 61 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.79526459 |
| 62 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.77505855 |
| 63 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.76131940 |
| 64 | Metabolic pathways_Homo sapiens_hsa01100 | 0.74706869 |
| 65 | Retinol metabolism_Homo sapiens_hsa00830 | 0.72368240 |
| 66 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.70097560 |
| 67 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.69265633 |
| 68 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.69201570 |
| 69 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.67242795 |
| 70 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.66684994 |
| 71 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.65960418 |
| 72 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.65070600 |
| 73 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.62821340 |
| 74 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.59966864 |
| 75 | Olfactory transduction_Homo sapiens_hsa04740 | 0.59033642 |
| 76 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.57240478 |
| 77 | Nicotine addiction_Homo sapiens_hsa05033 | 0.56447547 |
| 78 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.56081167 |
| 79 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.54797612 |
| 80 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.53928669 |
| 81 | Sulfur relay system_Homo sapiens_hsa04122 | 0.53023882 |
| 82 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.52187495 |
| 83 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.51085066 |
| 84 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.50782355 |
| 85 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.47794335 |
| 86 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.45255518 |
| 87 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.43322601 |
| 88 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.42933026 |
| 89 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.42718889 |
| 90 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.41811196 |
| 91 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.37699389 |
| 92 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.37248762 |
| 93 | Taste transduction_Homo sapiens_hsa04742 | 0.37204927 |
| 94 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.34966679 |
| 95 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.31434710 |
| 96 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.31173522 |
| 97 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.27937304 |
| 98 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.27529217 |
| 99 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.26116524 |
| 100 | GABAergic synapse_Homo sapiens_hsa04727 | 0.25660895 |

