ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA strand renaturation (GO:0000733)	6.50976375
2	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	5.50722682
3	proteasome assembly (GO:0043248)	5.38433170
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.26207464
5	antigen processing and presentation via MHC class Ib (GO:0002475)	4.83127962
6	platelet dense granule organization (GO:0060155)	4.24492082
7	rRNA modification (GO:0000154)	3.99932372
8	L-fucose catabolic process (GO:0042355)	3.99114384
9	fucose catabolic process (GO:0019317)	3.99114384
10	L-fucose metabolic process (GO:0042354)	3.99114384
11	rRNA methylation (GO:0031167)	3.87995802
12	DNA deamination (GO:0045006)	3.84574359
13	protein K11-linked deubiquitination (GO:0035871)	3.48491623
14	signal peptide processing (GO:0006465)	3.37000563
15	neural tube formation (GO:0001841)	3.35601518
16	replication fork processing (GO:0031297)	3.30163072
17	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.29382512
18	protein K6-linked ubiquitination (GO:0085020)	3.28384121
19	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.26786542
20	mannosylation (GO:0097502)	3.26751659
21	DNA double-strand break processing (GO:0000729)	3.17419505
22	dopamine transport (GO:0015872)	3.15490316
23	positive regulation of antigen processing and presentation (GO:0002579)	3.14930171
24	peptidyl-histidine modification (GO:0018202)	3.14886042
25	double-strand break repair via homologous recombination (GO:0000724)	3.13636031
26	maturation of 5.8S rRNA (GO:0000460)	3.09084713
27	recombinational repair (GO:0000725)	3.08528079
28	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.08133340
29	protein complex biogenesis (GO:0070271)	3.05853993
30	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.97233940
31	termination of RNA polymerase III transcription (GO:0006386)	2.97233940
32	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.94576467
33	pseudouridine synthesis (GO:0001522)	2.94335733
34	mitochondrial respiratory chain complex assembly (GO:0033108)	2.88831496
35	interferon-gamma production (GO:0032609)	2.85853378
36	respiratory chain complex IV assembly (GO:0008535)	2.82617490
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.82421980
38	centriole replication (GO:0007099)	2.80718206
39	male meiosis I (GO:0007141)	2.80371966
40	tRNA processing (GO:0008033)	2.77118513
41	behavioral response to nicotine (GO:0035095)	2.76118275
42	negative regulation of telomere maintenance (GO:0032205)	2.74597134
43	cytochrome complex assembly (GO:0017004)	2.73936887
44	lactate metabolic process (GO:0006089)	2.73542101
45	adaptation of signaling pathway (GO:0023058)	2.72923960
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.72537101
47	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.71762567
48	isotype switching (GO:0045190)	2.71762567
49	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.71762567
50	histone mRNA catabolic process (GO:0071044)	2.70929309
51	NADH dehydrogenase complex assembly (GO:0010257)	2.69661740
52	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.69661740
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.69661740
54	water-soluble vitamin biosynthetic process (GO:0042364)	2.68918393
55	cullin deneddylation (GO:0010388)	2.65192787
56	tRNA metabolic process (GO:0006399)	2.63427350
57	regulation of mitotic spindle checkpoint (GO:1903504)	2.63342768
58	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.63342768
59	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.62560352
60	protein polyglutamylation (GO:0018095)	2.62426879
61	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.61817161
62	ATP synthesis coupled proton transport (GO:0015986)	2.61817161
63	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.60935035
64	aldehyde catabolic process (GO:0046185)	2.58881708
65	tryptophan catabolic process (GO:0006569)	2.58030604
66	indole-containing compound catabolic process (GO:0042436)	2.58030604
67	indolalkylamine catabolic process (GO:0046218)	2.58030604
68	positive regulation of histone H3-K4 methylation (GO:0051571)	2.58009941
69	epithelial cilium movement (GO:0003351)	2.57167238
70	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.55778363
71	negative regulation of systemic arterial blood pressure (GO:0003085)	2.55724852
72	DNA catabolic process, exonucleolytic (GO:0000738)	2.55597353
73	reciprocal DNA recombination (GO:0035825)	2.55429174
74	reciprocal meiotic recombination (GO:0007131)	2.55429174
75	meiosis I (GO:0007127)	2.54359162
76	peptidyl-lysine trimethylation (GO:0018023)	2.54232047
77	basic amino acid transport (GO:0015802)	2.53037008
78	organelle membrane fusion (GO:0090174)	2.52157520
79	intracellular protein transmembrane import (GO:0044743)	2.50915945
80	histone mRNA metabolic process (GO:0008334)	2.50757797
81	telomere maintenance via telomerase (GO:0007004)	2.50487568
82	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.47744767
83	regulation of translation, ncRNA-mediated (GO:0045974)	2.46432186
84	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.46432186
85	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.46432186
86	regulation of cellular amino acid metabolic process (GO:0006521)	2.46351642
87	regulation of meiosis I (GO:0060631)	2.46142139
88	C-terminal protein lipidation (GO:0006501)	2.45200021
89	regulation of DNA endoreduplication (GO:0032875)	2.44991869
90	photoreceptor cell maintenance (GO:0045494)	2.44347279
91	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.43503084
92	rRNA catabolic process (GO:0016075)	2.42204581
93	protein neddylation (GO:0045116)	2.41830100
94	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.40668940
95	regulation of cilium movement (GO:0003352)	2.38969221
96	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.37759470
97	postreplication repair (GO:0006301)	2.37142494
98	polyol catabolic process (GO:0046174)	2.35136919
99	protein deneddylation (GO:0000338)	2.34638145
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.34461501

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.46187470
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.46542589
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.32453851
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.27690955
5	VDR_22108803_ChIP-Seq_LS180_Human	3.06625150
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.80179529
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.72167919
8	E2F7_22180533_ChIP-Seq_HELA_Human	2.60945667
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.48153828
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.48144034
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.21676393
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.21276427
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.16544519
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.14361818
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.00753595
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.99692682
17	* P300_19829295_ChIP-Seq_ESCs_Human	1.94811680
18	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.94154771
19	VDR_23849224_ChIP-Seq_CD4+_Human	1.91044164
20	EWS_26573619_Chip-Seq_HEK293_Human	1.90274677
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85160807
22	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.82285787
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.77709212
24	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.74139131
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69155169
26	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.69039587
27	FUS_26573619_Chip-Seq_HEK293_Human	1.68324197
28	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.63555625
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59787073
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.59415052
31	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.58681559
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.57023986
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.56790342
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56428557
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.55946794
36	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.55749298
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.54462848
38	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.51175208
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47116558
40	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.45250744
41	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.43725876
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41047692
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.40986519
44	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.37581033
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37111646
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.37070626
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37070626
48	FOXP3_21729870_ChIP-Seq_TREG_Human	1.35502377
49	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.34716796
50	P53_22387025_ChIP-Seq_ESCs_Mouse	1.32338426
51	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.31649997
52	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31647299
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.28994058
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28026328
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28026328
56	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.26720281
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.25470142
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25360992
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.24751674
60	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24249464
61	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23242079
62	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.22638371
63	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.21909638
64	P300_18555785_Chip-Seq_ESCs_Mouse	1.21529686
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21119835
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21119835
67	STAT3_23295773_ChIP-Seq_U87_Human	1.20536916
68	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.18021393
69	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.17156952
70	* TCF4_22108803_ChIP-Seq_LS180_Human	1.16353881
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15137863
72	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.15003843
73	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.14694972
74	TCF4_23295773_ChIP-Seq_U87_Human	1.14655683
75	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.14564626
76	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14564626
77	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.13841591
78	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.12855963
79	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.11047742
80	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.10943236
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10625117
82	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09289566
83	* NCOR_22424771_ChIP-Seq_293T_Human	1.08620727
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08578163
85	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.08139289
86	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07730523
87	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.06393291
88	* AR_25329375_ChIP-Seq_VCAP_Human	1.05931737
89	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.05205765
90	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04770518
91	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.04724035
92	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04614979
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03846271
94	AR_20517297_ChIP-Seq_VCAP_Human	1.03357004
95	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.02476630
96	ETV1_20927104_ChIP-Seq_GIST48_Human	1.02232706
97	GATA3_26560356_Chip-Seq_TH2_Human	1.02167723
98	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.02065041
99	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01776051
100	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.01261350

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	5.67717462
2	MP0000372_irregular_coat_pigmentation	4.12829316
3	MP0008877_abnormal_DNA_methylation	3.65062367
4	MP0000569_abnormal_digit_pigmentation	3.32069151
5	MP0001835_abnormal_antigen_presentation	2.85363794
6	MP0003878_abnormal_ear_physiology	2.77593735
7	MP0005377_hearing/vestibular/ear_phenot	2.77593735
8	MP0003195_calcinosis	2.53127315
9	MP0005075_abnormal_melanosome_morpholog	2.53091521
10	MP0008058_abnormal_DNA_repair	2.52599026
11	MP0005408_hypopigmentation	2.41700545
12	MP0005671_abnormal_response_to	2.23551921
13	MP0003646_muscle_fatigue	2.13700328
14	MP0002938_white_spotting	2.06328547
15	MP0001986_abnormal_taste_sensitivity	2.00394762
16	MP0005084_abnormal_gallbladder_morpholo	1.94891781
17	MP0008872_abnormal_physiological_respon	1.93333247
18	MP0005174_abnormal_tail_pigmentation	1.85325786
19	MP0006292_abnormal_olfactory_placode	1.81715979
20	MP0005551_abnormal_eye_electrophysiolog	1.80268093
21	MP0001485_abnormal_pinna_reflex	1.72115559
22	MP0004142_abnormal_muscle_tone	1.65516406
23	MP0000015_abnormal_ear_pigmentation	1.64064366
24	MP0003787_abnormal_imprinting	1.59454132
25	MP0002166_altered_tumor_susceptibility	1.58185061
26	MP0002006_tumorigenesis	1.51859486
27	MP0002095_abnormal_skin_pigmentation	1.48639848
28	MP0000427_abnormal_hair_cycle	1.45960914
29	MP0006072_abnormal_retinal_apoptosis	1.45379547
30	MP0003718_maternal_effect	1.44789825
31	MP0000685_abnormal_immune_system	1.44353005
32	MP0001486_abnormal_startle_reflex	1.44073406
33	MP0002837_dystrophic_cardiac_calcinosis	1.38741246
34	MP0002254_reproductive_system_inflammat	1.38012265
35	MP0008875_abnormal_xenobiotic_pharmacok	1.34032789
36	MP0010094_abnormal_chromosome_stability	1.33179445
37	MP0005253_abnormal_eye_physiology	1.32933363
38	MP0001968_abnormal_touch/_nociception	1.31259340
39	MP0003786_premature_aging	1.24532412
40	MP0002638_abnormal_pupillary_reflex	1.22277384
41	MP0002736_abnormal_nociception_after	1.20843215
42	MP0001873_stomach_inflammation	1.17301330
43	MP0002876_abnormal_thyroid_physiology	1.15988206
44	MP0003137_abnormal_impulse_conducting	1.14410409
45	MP0003111_abnormal_nucleus_morphology	1.14363056
46	MP0001529_abnormal_vocalization	1.10796938
47	MP0008057_abnormal_DNA_replication	1.10052380
48	MP0003136_yellow_coat_color	1.09817878
49	MP0002272_abnormal_nervous_system	1.09814268
50	MP0003011_delayed_dark_adaptation	1.05060283
51	MP0005646_abnormal_pituitary_gland	1.04049995
52	MP0000371_diluted_coat_color	1.01877863
53	MP0004381_abnormal_hair_follicle	1.00395221
54	MP0009046_muscle_twitch	1.00170761
55	MP0009745_abnormal_behavioral_response	0.98307902
56	MP0000631_abnormal_neuroendocrine_gland	0.97785173
57	MP0002163_abnormal_gland_morphology	0.97173047
58	MP0004742_abnormal_vestibular_system	0.96798672
59	MP0008995_early_reproductive_senescence	0.96693581
60	MP0003186_abnormal_redox_activity	0.96673666
61	MP0001984_abnormal_olfaction	0.94286325
62	MP0003806_abnormal_nucleotide_metabolis	0.93870424
63	MP0001501_abnormal_sleep_pattern	0.93748275
64	MP0004147_increased_porphyrin_level	0.92793711
65	MP0001324_abnormal_eye_pigmentation	0.91341276
66	MP0005310_abnormal_salivary_gland	0.90897853
67	MP0005171_absent_coat_pigmentation	0.87558244
68	MP0002138_abnormal_hepatobiliary_system	0.85384780
69	MP0001440_abnormal_grooming_behavior	0.84632557
70	MP0004885_abnormal_endolymph	0.83926820
71	MP0002396_abnormal_hematopoietic_system	0.82488441
72	MP0005645_abnormal_hypothalamus_physiol	0.80737070
73	MP0006036_abnormal_mitochondrial_physio	0.79751324
74	MP0003693_abnormal_embryo_hatching	0.79111972
75	MP0003937_abnormal_limbs/digits/tail_de	0.77448463
76	MP0001764_abnormal_homeostasis	0.77208253
77	MP0004924_abnormal_behavior	0.74716720
78	MP0005386_behavior/neurological_phenoty	0.74716720
79	MP0002751_abnormal_autonomic_nervous	0.73982070
80	MP0005387_immune_system_phenotype	0.73188533
81	MP0001790_abnormal_immune_system	0.73188533
82	MP0002693_abnormal_pancreas_physiology	0.72820066
83	MP0002234_abnormal_pharynx_morphology	0.71159473
84	MP0005647_abnormal_sex_gland	0.71000623
85	MP0001119_abnormal_female_reproductive	0.70477413
86	MP0002282_abnormal_trachea_morphology	0.70062480
87	MP0002277_abnormal_respiratory_mucosa	0.69517200
88	MP0000613_abnormal_salivary_gland	0.68477543
89	MP0001800_abnormal_humoral_immune	0.65889916
90	MP0003121_genomic_imprinting	0.64759771
91	MP0002067_abnormal_sensory_capabilities	0.64507050
92	MP0005379_endocrine/exocrine_gland_phen	0.64505271
93	MP0002928_abnormal_bile_duct	0.62760934
94	MP0001929_abnormal_gametogenesis	0.62738412
95	MP0002229_neurodegeneration	0.61301625
96	MP0003950_abnormal_plasma_membrane	0.60942265
97	MP0003252_abnormal_bile_duct	0.59586699
98	MP0004133_heterotaxia	0.59462322
99	MP0002148_abnormal_hypersensitivity_rea	0.59086368
100	MP0001293_anophthalmia	0.58518280

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic otitis media (HP:0000389)	4.59879660
2	Elevated erythrocyte sedimentation rate (HP:0003565)	4.37511857
3	Progressive inability to walk (HP:0002505)	4.09659227
4	Hypoproteinemia (HP:0003075)	3.59806227
5	Chronic sinusitis (HP:0011109)	3.54495514
6	Shawl scrotum (HP:0000049)	3.38343037
7	Stomatitis (HP:0010280)	3.31981958
8	Abnormality of midbrain morphology (HP:0002418)	3.31005806
9	Molar tooth sign on MRI (HP:0002419)	3.31005806
10	Pancreatic cysts (HP:0001737)	3.17833788
11	Acute necrotizing encephalopathy (HP:0006965)	3.15877336
12	Congenital stationary night blindness (HP:0007642)	3.11509468
13	Large for gestational age (HP:0001520)	3.06390978
14	Rib fusion (HP:0000902)	2.99486157
15	Flat capital femoral epiphysis (HP:0003370)	2.94654977
16	Pancreatic fibrosis (HP:0100732)	2.89006892
17	Progressive macrocephaly (HP:0004481)	2.83876977
18	Nephronophthisis (HP:0000090)	2.82031839
19	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.81083112
20	Acute encephalopathy (HP:0006846)	2.77918488
21	Mitochondrial inheritance (HP:0001427)	2.69663416
22	True hermaphroditism (HP:0010459)	2.68484248
23	Increased CSF lactate (HP:0002490)	2.68022845
24	Recurrent bronchitis (HP:0002837)	2.66803567
25	Abnormality of the renal cortex (HP:0011035)	2.63704466
26	Esophageal atresia (HP:0002032)	2.63524438
27	Muscle fiber atrophy (HP:0100295)	2.61669039
28	Tubular atrophy (HP:0000092)	2.60747454
29	Clubbing of toes (HP:0100760)	2.56346502
30	Type I transferrin isoform profile (HP:0003642)	2.54591371
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.52380632
32	Inability to walk (HP:0002540)	2.47339912
33	Abnormality of macular pigmentation (HP:0008002)	2.43991415
34	Abnormality of the renal medulla (HP:0100957)	2.42766780
35	Volvulus (HP:0002580)	2.40828249
36	Patellar aplasia (HP:0006443)	2.38604747
37	Gastrointestinal atresia (HP:0002589)	2.32923411
38	Patchy hypopigmentation of hair (HP:0011365)	2.32145342
39	Abolished electroretinogram (ERG) (HP:0000550)	2.31098872
40	Nasal polyposis (HP:0100582)	2.29515613
41	Medial flaring of the eyebrow (HP:0010747)	2.28780743
42	Gaze-evoked nystagmus (HP:0000640)	2.26888792
43	Aplasia/Hypoplasia of the patella (HP:0006498)	2.25497747
44	Oligodactyly (hands) (HP:0001180)	2.25271687
45	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.23196768
46	Hypoplasia of the fovea (HP:0007750)	2.22736665
47	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.22736665
48	Methylmalonic acidemia (HP:0002912)	2.21110642
49	Hepatocellular necrosis (HP:0001404)	2.19956126
50	Increased serum lactate (HP:0002151)	2.18716888
51	IgG deficiency (HP:0004315)	2.15986851
52	Abnormality of the pons (HP:0007361)	2.10533342
53	Abnormality of the labia minora (HP:0012880)	2.06901252
54	Abnormality of chromosome stability (HP:0003220)	2.05921814
55	Cerebral edema (HP:0002181)	2.05126222
56	Hypoplasia of the pons (HP:0012110)	2.02504420
57	Abnormal protein glycosylation (HP:0012346)	2.02325519
58	Abnormal glycosylation (HP:0012345)	2.02325519
59	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.02325519
60	Abnormal protein N-linked glycosylation (HP:0012347)	2.02325519
61	Hepatic necrosis (HP:0002605)	2.02197880
62	Aplasia/Hypoplasia of the macula (HP:0008059)	2.01267140
63	Chromsome breakage (HP:0040012)	2.00776331
64	Congenital, generalized hypertrichosis (HP:0004540)	2.00363053
65	Lipid accumulation in hepatocytes (HP:0006561)	2.00336888
66	Renal cortical cysts (HP:0000803)	1.99060298
67	Respiratory difficulties (HP:0002880)	1.98210869
68	Optic disc pallor (HP:0000543)	1.97850381
69	Abnormal albumin level (HP:0012116)	1.97495723
70	Hypoalbuminemia (HP:0003073)	1.97495723
71	Increased hepatocellular lipid droplets (HP:0006565)	1.95564707
72	Attenuation of retinal blood vessels (HP:0007843)	1.95207534
73	Meckel diverticulum (HP:0002245)	1.94391843
74	Decreased central vision (HP:0007663)	1.93763054
75	Ependymoma (HP:0002888)	1.92548289
76	Abnormality of the ileum (HP:0001549)	1.90623416
77	Neonatal respiratory distress (HP:0002643)	1.89790886
78	3-Methylglutaconic aciduria (HP:0003535)	1.89667967
79	Severe visual impairment (HP:0001141)	1.89454989
80	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87830674
81	Bronchitis (HP:0012387)	1.87812808
82	Type II lissencephaly (HP:0007260)	1.86843118
83	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.86586785
84	Large eyes (HP:0001090)	1.85627506
85	Abnormality of the fovea (HP:0000493)	1.84155731
86	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.82761071
87	Intestinal atresia (HP:0011100)	1.82526487
88	Methylmalonic aciduria (HP:0012120)	1.80512977
89	Colon cancer (HP:0003003)	1.80263359
90	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.70444871
91	Dyschromatopsia (HP:0007641)	1.70018413
92	Lactic acidosis (HP:0003128)	1.68994441
93	Thyroiditis (HP:0100646)	1.67823047
94	Growth hormone deficiency (HP:0000824)	1.67482988
95	Cystic liver disease (HP:0006706)	1.66661570
96	Small intestinal stenosis (HP:0012848)	1.66656323
97	Duodenal stenosis (HP:0100867)	1.66656323
98	Preaxial hand polydactyly (HP:0001177)	1.64255604
99	Congenital primary aphakia (HP:0007707)	1.62656984
100	Pendular nystagmus (HP:0012043)	1.62456695

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.53167239
2	NUAK1	3.83408781
3	TSSK6	3.08035390
4	MST4	2.81816333
5	TGFBR2	2.71652735
6	BMPR1B	2.46877558
7	EIF2AK3	2.26512877
8	GRK7	2.22566173
9	EIF2AK1	2.14733698
10	GRK1	2.05830765
11	TRIM28	2.00368936
12	PLK3	1.93077209
13	PLK4	1.91614887
14	PLK2	1.89531880
15	ZAK	1.81070734
16	ADRBK2	1.78393732
17	GRK5	1.75787571
18	NEK1	1.74895373
19	TNIK	1.73189951
20	PDK2	1.67624524
21	VRK1	1.65245056
22	WNK3	1.58718139
23	VRK2	1.58523805
24	TEC	1.53707765
25	INSRR	1.53697710
26	MKNK2	1.49005742
27	MAP4K2	1.48163211
28	TAOK3	1.46266079
29	PINK1	1.30571128
30	MAPK13	1.28935800
31	WEE1	1.25817683
32	MAP2K6	1.23526298
33	WNK4	1.20817056
34	TIE1	1.17309311
35	BUB1	1.14808535
36	NME1	1.11451260
37	EIF2AK2	1.09777088
38	ACVR1B	1.04906515
39	TXK	0.99397178
40	PNCK	0.98858984
41	PAK3	0.98526323
42	BCKDK	0.94529598
43	STK10	0.93188266
44	PBK	0.91915202
45	ADRBK1	0.89959999
46	PTK2B	0.86098968
47	FGFR2	0.84940310
48	MOS	0.84342407
49	TLK1	0.83180065
50	STK39	0.82496424
51	STK16	0.80837822
52	PRKCG	0.78173532
53	IRAK1	0.76029885
54	OXSR1	0.75046795
55	ITK	0.73654843
56	SIK3	0.73042813
57	NEK2	0.67940247
58	KIT	0.67736602
59	BCR	0.67247962
60	PIK3CG	0.66557670
61	PLK1	0.65721939
62	STK3	0.65628847
63	IKBKB	0.65123510
64	ERBB4	0.63529280
65	TGFBR1	0.62935678
66	TNK2	0.61971179
67	MAPKAPK3	0.61439200
68	MKNK1	0.60876206
69	PRKCE	0.60198021
70	WNK1	0.59598302
71	SRPK1	0.54096848
72	AKT3	0.50359957
73	TAF1	0.50085999
74	BRSK2	0.49639303
75	ATM	0.48008032
76	NLK	0.47455163
77	CLK1	0.46363561
78	TRPM7	0.44879837
79	ATR	0.44431218
80	PRKCQ	0.41281978
81	OBSCN	0.37443600
82	STK4	0.36894013
83	CHEK2	0.36549656
84	MINK1	0.36512248
85	CSNK1A1	0.36137913
86	PRKG1	0.35916500
87	MAPKAPK5	0.35388953
88	MAP3K12	0.34946502
89	PRKACA	0.34794604
90	IKBKE	0.33928471
91	CHEK1	0.33437857
92	CSNK1G1	0.32762144
93	CASK	0.32367846
94	MAP3K4	0.32335510
95	CAMK2A	0.31186929
96	CSNK2A2	0.29564387
97	PRKACB	0.27741458
98	CSNK2A1	0.27500752
99	CSNK1E	0.27479587
100	CDC7	0.27336693

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.58339510
2	Protein export_Homo sapiens_hsa03060	3.52496573
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.08742658
4	Homologous recombination_Homo sapiens_hsa03440	2.64532373
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.62537349
6	RNA polymerase_Homo sapiens_hsa03020	2.56931828
7	Basal transcription factors_Homo sapiens_hsa03022	2.22917478
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.21021316
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.10085951
10	RNA degradation_Homo sapiens_hsa03018	2.08473537
11	Propanoate metabolism_Homo sapiens_hsa00640	2.04396002
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.92066168
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.83216900
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79543902
15	Parkinsons disease_Homo sapiens_hsa05012	1.73915327
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67599531
17	Phototransduction_Homo sapiens_hsa04744	1.64924004
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.57614617
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.56748035
20	One carbon pool by folate_Homo sapiens_hsa00670	1.53349614
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.53007699
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48790399
23	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.41491075
24	Butanoate metabolism_Homo sapiens_hsa00650	1.41076253
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.40697353
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.37307916
27	ABC transporters_Homo sapiens_hsa02010	1.36493767
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.35324347
29	Mismatch repair_Homo sapiens_hsa03430	1.34194588
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.30521827
31	RNA transport_Homo sapiens_hsa03013	1.29751632
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.25805453
33	Asthma_Homo sapiens_hsa05310	1.23858711
34	beta-Alanine metabolism_Homo sapiens_hsa00410	1.19031159
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16874091
36	Huntingtons disease_Homo sapiens_hsa05016	1.16194551
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.15980233
38	Fatty acid degradation_Homo sapiens_hsa00071	1.07049671
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06080328
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04529534
41	Caffeine metabolism_Homo sapiens_hsa00232	1.04198474
42	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99075586
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.98689513
44	Sulfur metabolism_Homo sapiens_hsa00920	0.96421557
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96104663
46	Ether lipid metabolism_Homo sapiens_hsa00565	0.94376839
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92760616
48	Alzheimers disease_Homo sapiens_hsa05010	0.90769720
49	Purine metabolism_Homo sapiens_hsa00230	0.89832010
50	Fatty acid elongation_Homo sapiens_hsa00062	0.89093060
51	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.86963187
52	Allograft rejection_Homo sapiens_hsa05330	0.85995586
53	Peroxisome_Homo sapiens_hsa04146	0.84102904
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.82466245
55	Spliceosome_Homo sapiens_hsa03040	0.82038996
56	Histidine metabolism_Homo sapiens_hsa00340	0.81760678
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.79436801
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79342125
59	Type I diabetes mellitus_Homo sapiens_hsa04940	0.78634024
60	Regulation of autophagy_Homo sapiens_hsa04140	0.77496247
61	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.75651368
62	Mineral absorption_Homo sapiens_hsa04978	0.75223931
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.75196882
64	Retinol metabolism_Homo sapiens_hsa00830	0.72917457
65	Ribosome_Homo sapiens_hsa03010	0.71646711
66	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.71447280
67	Taste transduction_Homo sapiens_hsa04742	0.70725761
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69161558
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69160733
70	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.69089799
71	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.68974670
72	Olfactory transduction_Homo sapiens_hsa04740	0.67494367
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65161028
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64876033
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64438042
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.63594834
77	Metabolic pathways_Homo sapiens_hsa01100	0.63481984
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63417899
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63133498
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61731271
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.60372099
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56400083
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55752189
84	Steroid biosynthesis_Homo sapiens_hsa00100	0.55026181
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52879557
86	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49743984
87	Insulin secretion_Homo sapiens_hsa04911	0.49569105
88	Nicotine addiction_Homo sapiens_hsa05033	0.49323884
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.48568716
90	Base excision repair_Homo sapiens_hsa03410	0.46496773
91	DNA replication_Homo sapiens_hsa03030	0.46461534
92	Antigen processing and presentation_Homo sapiens_hsa04612	0.46134695
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.46049353
94	Glutathione metabolism_Homo sapiens_hsa00480	0.45380244
95	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45097962
96	Salivary secretion_Homo sapiens_hsa04970	0.44521237
97	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.43934847
98	Graft-versus-host disease_Homo sapiens_hsa05332	0.41872122
99	Measles_Homo sapiens_hsa05162	0.37499026
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36521127

HSP90AB4P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »