ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of 5.8S rRNA (GO:0000460)	5.32099075
2	somatic hypermutation of immunoglobulin genes (GO:0016446)	5.29565161
3	somatic diversification of immune receptors via somatic mutation (GO:0002566)	5.29565161
4	DNA deamination (GO:0045006)	4.96237189
5	protein deneddylation (GO:0000338)	4.65832603
6	cullin deneddylation (GO:0010388)	4.51843536
7	behavioral response to nicotine (GO:0035095)	4.38768472
8	regulation of helicase activity (GO:0051095)	4.13751678
9	rRNA catabolic process (GO:0016075)	4.06704389
10	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	4.05797980
11	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	4.05797980
12	isotype switching (GO:0045190)	4.05797980
13	response to gravity (GO:0009629)	3.83590904
14	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.76304491
15	pseudouridine synthesis (GO:0001522)	3.70961551
16	negative regulation of DNA recombination (GO:0045910)	3.59163872
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.49452901
18	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.38761620
19	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.38761620
20	fucose catabolic process (GO:0019317)	3.29828538
21	L-fucose metabolic process (GO:0042354)	3.29828538
22	L-fucose catabolic process (GO:0042355)	3.29828538
23	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29500779
24	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.29002660
25	DNA catabolic process, exonucleolytic (GO:0000738)	3.28379757
26	protein neddylation (GO:0045116)	3.26577127
27	negative regulation of telomere maintenance (GO:0032205)	3.24195245
28	rRNA modification (GO:0000154)	3.23761824
29	chaperone-mediated protein transport (GO:0072321)	3.19824901
30	protein complex biogenesis (GO:0070271)	3.19108719
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.15884245
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.15884245
33	NADH dehydrogenase complex assembly (GO:0010257)	3.15884245
34	GTP biosynthetic process (GO:0006183)	3.15325215
35	peptidyl-histidine modification (GO:0018202)	3.11816937
36	replication fork processing (GO:0031297)	3.08820176
37	regulation of cellular amino acid metabolic process (GO:0006521)	3.07303798
38	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.05965046
39	proteasome assembly (GO:0043248)	3.05922285
40	DNA double-strand break processing (GO:0000729)	3.04690658
41	somatic diversification of immunoglobulins (GO:0016445)	3.04157703
42	mannosylation (GO:0097502)	3.03970841
43	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.03391860
44	termination of RNA polymerase III transcription (GO:0006386)	3.03391860
45	platelet dense granule organization (GO:0060155)	3.03277326
46	mitochondrial respiratory chain complex assembly (GO:0033108)	2.96432547
47	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.95700568
48	folic acid-containing compound biosynthetic process (GO:0009396)	2.93336665
49	protein polyglutamylation (GO:0018095)	2.93080284
50	reciprocal meiotic recombination (GO:0007131)	2.92374967
51	reciprocal DNA recombination (GO:0035825)	2.92374967
52	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.91071254
53	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.89333325
54	protein K6-linked ubiquitination (GO:0085020)	2.88625540
55	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.87993667
56	rRNA methylation (GO:0031167)	2.86157301
57	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.85330452
58	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.85330452
59	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.85330452
60	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.78618602
61	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.78618602
62	ncRNA catabolic process (GO:0034661)	2.77249191
63	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.74079343
64	positive regulation of prostaglandin secretion (GO:0032308)	2.73959517
65	regulation of isotype switching to IgG isotypes (GO:0048302)	2.72471476
66	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.72363693
67	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.72222318
68	resolution of meiotic recombination intermediates (GO:0000712)	2.71395066
69	negative regulation of ligase activity (GO:0051352)	2.70832779
70	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.70832779
71	cytidine metabolic process (GO:0046087)	2.70500885
72	cytidine catabolic process (GO:0006216)	2.70500885
73	cytidine deamination (GO:0009972)	2.70500885
74	tRNA processing (GO:0008033)	2.69964019
75	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.69888123
76	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.69888123
77	ATP synthesis coupled proton transport (GO:0015986)	2.69671173
78	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.69671173
79	histone mRNA metabolic process (GO:0008334)	2.69249379
80	UTP biosynthetic process (GO:0006228)	2.68385016
81	double-strand break repair via homologous recombination (GO:0000724)	2.66673181
82	recombinational repair (GO:0000725)	2.66518077
83	ribosome assembly (GO:0042255)	2.65253989
84	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.65239496
85	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.64059292
86	positive regulation of natural killer cell differentiation (GO:0032825)	2.64009595
87	tRNA metabolic process (GO:0006399)	2.63659213
88	regulation of defense response to virus by host (GO:0050691)	2.63427400
89	ubiquinone biosynthetic process (GO:0006744)	2.63066469
90	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.60221519
91	tRNA modification (GO:0006400)	2.59728967
92	regulation of chronic inflammatory response (GO:0002676)	2.59667780
93	protein-cofactor linkage (GO:0018065)	2.59485752
94	mismatch repair (GO:0006298)	2.59052083
95	regulation of mitotic spindle checkpoint (GO:1903504)	2.58809300
96	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.58809300
97	IMP biosynthetic process (GO:0006188)	2.55591682
98	termination of RNA polymerase I transcription (GO:0006363)	2.55408704
99	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.54327764
100	amino acid activation (GO:0043038)	2.53653352

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.75516373
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.01826932
3	VDR_22108803_ChIP-Seq_LS180_Human	3.90792588
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.29801433
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.98958686
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.84586869
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.78892320
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.77131424
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.68048719
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.67369445
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.53585777
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.52751749
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.48868534
14	E2F7_22180533_ChIP-Seq_HELA_Human	2.31884286
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.31324674
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.17609533
17	EWS_26573619_Chip-Seq_HEK293_Human	2.14552814
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.03741583
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.03684195
20	MYC_18940864_ChIP-ChIP_HL60_Human	2.03320202
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.01118348
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.98929742
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.93932123
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.86221480
25	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.84187569
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.79370809
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.78339494
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.76236931
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.74847377
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.74126103
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.66529447
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.65011806
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57653252
34	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.56708331
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.56135525
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.54351594
37	P300_19829295_ChIP-Seq_ESCs_Human	1.54248583
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.54102235
39	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.53782848
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.50031759
41	FUS_26573619_Chip-Seq_HEK293_Human	1.48121848
42	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.42615250
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.40146907
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.38626343
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.38196659
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.33143983
47	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30583022
48	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.27068098
49	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.26040831
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25808752
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25808752
52	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.25450865
53	GBX2_23144817_ChIP-Seq_PC3_Human	1.24929297
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24547119
55	AR_20517297_ChIP-Seq_VCAP_Human	1.24169826
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23251634
57	NCOR_22424771_ChIP-Seq_293T_Human	1.22171902
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22059467
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20678979
60	GATA3_26560356_Chip-Seq_TH2_Human	1.19926651
61	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16333655
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15433487
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13778650
64	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.13682174
65	GABP_19822575_ChIP-Seq_HepG2_Human	1.13456604
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12689166
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12689166
68	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12583571
69	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.11375097
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09565475
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09225287
72	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.08462777
73	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.07879943
74	CBP_20019798_ChIP-Seq_JUKART_Human	1.07228547
75	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07228547
76	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06461269
77	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06461269
78	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.05773435
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05736611
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05063720
81	AR_21572438_ChIP-Seq_LNCaP_Human	1.04034058
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02431521
83	TTF2_22483619_ChIP-Seq_HELA_Human	1.00709931
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00336144
85	TCF4_22108803_ChIP-Seq_LS180_Human	1.00218129
86	GATA1_22025678_ChIP-Seq_K562_Human	0.99195348
87	IGF1R_20145208_ChIP-Seq_DFB_Human	0.97934400
88	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.95591545
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95145126
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94756955
91	BCAT_22108803_ChIP-Seq_LS180_Human	0.94068864
92	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.92801856
93	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.89963723
94	RBPJ_21746931_ChIP-Seq_IB4_Human	0.87819145
95	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.87460963
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.87277643
97	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.87054418
98	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.86845034
99	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86138401
100	GATA3_26560356_Chip-Seq_TH1_Human	0.85932170

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.62962633
2	MP0002736_abnormal_nociception_after	3.17569099
3	MP0008877_abnormal_DNA_methylation	3.05717356
4	MP0002138_abnormal_hepatobiliary_system	2.99275633
5	MP0001968_abnormal_touch/_nociception	2.96506664
6	MP0000569_abnormal_digit_pigmentation	2.92014075
7	MP0008875_abnormal_xenobiotic_pharmacok	2.79110608
8	MP0002102_abnormal_ear_morphology	2.47712981
9	MP0008872_abnormal_physiological_respon	2.45932811
10	MP0003787_abnormal_imprinting	2.15388823
11	MP0001873_stomach_inflammation	2.12425022
12	MP0002837_dystrophic_cardiac_calcinosis	1.93756874
13	MP0003718_maternal_effect	1.93698507
14	MP0008058_abnormal_DNA_repair	1.93265454
15	MP0003195_calcinosis	1.88692173
16	MP0001986_abnormal_taste_sensitivity	1.88670987
17	MP0006072_abnormal_retinal_apoptosis	1.76506988
18	MP0002638_abnormal_pupillary_reflex	1.76416309
19	MP0004145_abnormal_muscle_electrophysio	1.75011962
20	MP0000372_irregular_coat_pigmentation	1.70264437
21	MP0009745_abnormal_behavioral_response	1.70061346
22	MP0006035_abnormal_mitochondrial_morpho	1.68940577
23	MP0004742_abnormal_vestibular_system	1.68445395
24	MP0001835_abnormal_antigen_presentation	1.51515918
25	MP0006036_abnormal_mitochondrial_physio	1.46525263
26	MP0005646_abnormal_pituitary_gland	1.45322943
27	MP0002272_abnormal_nervous_system	1.44930715
28	MP0001529_abnormal_vocalization	1.44762921
29	MP0005671_abnormal_response_to	1.43051031
30	MP0002166_altered_tumor_susceptibility	1.41630432
31	MP0003786_premature_aging	1.38992678
32	MP0005551_abnormal_eye_electrophysiolog	1.38744772
33	MP0004885_abnormal_endolymph	1.37179070
34	MP0005645_abnormal_hypothalamus_physiol	1.34000403
35	MP0002876_abnormal_thyroid_physiology	1.33773189
36	MP0004142_abnormal_muscle_tone	1.32459954
37	MP0003186_abnormal_redox_activity	1.32327377
38	MP0009046_muscle_twitch	1.31231674
39	MP0008775_abnormal_heart_ventricle	1.29864589
40	MP0005167_abnormal_blood-brain_barrier	1.27200909
41	MP0003646_muscle_fatigue	1.25949294
42	MP0006292_abnormal_olfactory_placode	1.23954146
43	MP0002006_tumorigenesis	1.22952777
44	MP0000427_abnormal_hair_cycle	1.21815196
45	MP0001984_abnormal_olfaction	1.20019179
46	MP0001905_abnormal_dopamine_level	1.18537201
47	MP0002277_abnormal_respiratory_mucosa	1.16597467
48	MP0005636_abnormal_mineral_homeostasis	1.15247135
49	MP0008789_abnormal_olfactory_epithelium	1.13354784
50	MP0003693_abnormal_embryo_hatching	1.11309593
51	MP0009333_abnormal_splenocyte_physiolog	1.09979967
52	MP0001348_abnormal_lacrimal_gland	1.09748520
53	MP0001486_abnormal_startle_reflex	1.08417560
54	MP0001790_abnormal_immune_system	1.07737316
55	MP0005387_immune_system_phenotype	1.07737316
56	MP0005084_abnormal_gallbladder_morpholo	1.07134524
57	MP0002733_abnormal_thermal_nociception	1.06848806
58	MP0010094_abnormal_chromosome_stability	1.02600098
59	MP0005253_abnormal_eye_physiology	1.01805819
60	MP0001501_abnormal_sleep_pattern	0.99217102
61	MP0008007_abnormal_cellular_replicative	0.99128587
62	MP0005075_abnormal_melanosome_morpholog	0.94032240
63	MP0005423_abnormal_somatic_nervous	0.92574654
64	MP0005332_abnormal_amino_acid	0.92351041
65	MP0005389_reproductive_system_phenotype	0.92021565
66	MP0002751_abnormal_autonomic_nervous	0.90739049
67	MP0003136_yellow_coat_color	0.90048391
68	MP0001485_abnormal_pinna_reflex	0.88015401
69	MP0001800_abnormal_humoral_immune	0.87523876
70	MP0006276_abnormal_autonomic_nervous	0.87281907
71	MP0001970_abnormal_pain_threshold	0.85140296
72	MP0001243_abnormal_dermal_layer	0.83291045
73	MP0001440_abnormal_grooming_behavior	0.83181300
74	MP0003866_abnormal_defecation	0.82557080
75	MP0003806_abnormal_nucleotide_metabolis	0.80462781
76	MP0003045_fibrosis	0.79851530
77	MP0002064_seizures	0.79843901
78	MP0002095_abnormal_skin_pigmentation	0.79661709
79	MP0001919_abnormal_reproductive_system	0.78685353
80	MP0002067_abnormal_sensory_capabilities	0.78417326
81	MP0000685_abnormal_immune_system	0.78293197
82	MP0002572_abnormal_emotion/affect_behav	0.77654884
83	MP0004215_abnormal_myocardial_fiber	0.77334207
84	MP0005083_abnormal_biliary_tract	0.76350953
85	MP0002332_abnormal_exercise_endurance	0.76215853
86	MP0002163_abnormal_gland_morphology	0.75974740
87	MP0003252_abnormal_bile_duct	0.75407282
88	MP0009764_decreased_sensitivity_to	0.74392269
89	MP0002160_abnormal_reproductive_system	0.73735902
90	MP0001765_abnormal_ion_homeostasis	0.72434776
91	MP0002938_white_spotting	0.72415053
92	MP0000749_muscle_degeneration	0.69588509
93	MP0002557_abnormal_social/conspecific_i	0.69249882
94	MP0002693_abnormal_pancreas_physiology	0.68745370
95	MP0003880_abnormal_central_pattern	0.68225898
96	MP0002735_abnormal_chemical_nociception	0.68109970
97	MP0009765_abnormal_xenobiotic_induced	0.67431903
98	MP0005395_other_phenotype	0.66108765
99	MP0004133_heterotaxia	0.65369546
100	MP0002723_abnormal_immune_serum	0.64795367

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Agnosia (HP:0010524)	3.55940272
2	Ependymoma (HP:0002888)	3.52958080
3	Pancreatic cysts (HP:0001737)	3.23164292
4	Progressive inability to walk (HP:0002505)	3.12328649
5	Acute necrotizing encephalopathy (HP:0006965)	3.09975888
6	Abnormality of the renal cortex (HP:0011035)	3.06383652
7	Congenital, generalized hypertrichosis (HP:0004540)	2.88845033
8	Increased CSF lactate (HP:0002490)	2.84051778
9	Meckel diverticulum (HP:0002245)	2.77425932
10	Congenital stationary night blindness (HP:0007642)	2.76382830
11	Abnormality of the ileum (HP:0001549)	2.73093900
12	Acute encephalopathy (HP:0006846)	2.72831020
13	Renal cortical cysts (HP:0000803)	2.72309039
14	Inability to walk (HP:0002540)	2.72100904
15	Mitochondrial inheritance (HP:0001427)	2.68973898
16	Medulloblastoma (HP:0002885)	2.67114405
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.65455875
18	Methylmalonic acidemia (HP:0002912)	2.58770578
19	Abnormality of alanine metabolism (HP:0010916)	2.58001473
20	Hyperalaninemia (HP:0003348)	2.58001473
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.58001473
22	Increased hepatocellular lipid droplets (HP:0006565)	2.56339799
23	Hypoplasia of the pons (HP:0012110)	2.54521611
24	Aplasia/hypoplasia of the uterus (HP:0008684)	2.46850205
25	Progressive macrocephaly (HP:0004481)	2.46661127
26	Lipid accumulation in hepatocytes (HP:0006561)	2.46064220
27	Type I transferrin isoform profile (HP:0003642)	2.44290557
28	Hyperglycinuria (HP:0003108)	2.42112585
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.39127599
30	Nephronophthisis (HP:0000090)	2.37596343
31	Abnormality of the pons (HP:0007361)	2.36810937
32	Abnormality of the renal medulla (HP:0100957)	2.35027115
33	Pancreatic fibrosis (HP:0100732)	2.33685230
34	Rhabdomyosarcoma (HP:0002859)	2.32762503
35	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.32476799
36	Increased corneal curvature (HP:0100692)	2.31807940
37	Keratoconus (HP:0000563)	2.31807940
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.31108074
39	Oligomenorrhea (HP:0000876)	2.30669487
40	Abnormality of midbrain morphology (HP:0002418)	2.30436664
41	Molar tooth sign on MRI (HP:0002419)	2.30436664
42	Decreased central vision (HP:0007663)	2.29905088
43	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.26746170
44	Increased serum lactate (HP:0002151)	2.26161267
45	Type II lissencephaly (HP:0007260)	2.24830137
46	Abnormality of the preputium (HP:0100587)	2.24398699
47	Hepatic necrosis (HP:0002605)	2.23506128
48	Optic disc pallor (HP:0000543)	2.21954136
49	Abnormality of the astrocytes (HP:0100707)	2.19517650
50	Astrocytoma (HP:0009592)	2.19517650
51	Testicular atrophy (HP:0000029)	2.19462727
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.16724961
53	Fibular aplasia (HP:0002990)	2.16484016
54	Aplastic anemia (HP:0001915)	2.16018462
55	Conical tooth (HP:0000698)	2.15572202
56	Oral leukoplakia (HP:0002745)	2.15281074
57	Hepatocellular necrosis (HP:0001404)	2.15273689
58	Supernumerary spleens (HP:0009799)	2.14295307
59	Abnormal drinking behavior (HP:0030082)	2.13072549
60	Polydipsia (HP:0001959)	2.13072549
61	Tubular atrophy (HP:0000092)	2.12841544
62	Delayed CNS myelination (HP:0002188)	2.10515141
63	Methylmalonic aciduria (HP:0012120)	2.08752247
64	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.06354386
65	Atonic seizures (HP:0010819)	2.03936850
66	True hermaphroditism (HP:0010459)	2.03915123
67	Abnormality of the labia minora (HP:0012880)	2.03576173
68	IgG deficiency (HP:0004315)	1.99944353
69	Hypothermia (HP:0002045)	1.98921592
70	Abnormal biliary tract physiology (HP:0012439)	1.98807302
71	Bile duct proliferation (HP:0001408)	1.98807302
72	Stomatitis (HP:0010280)	1.98251590
73	Glioma (HP:0009733)	1.98014711
74	Cerebral edema (HP:0002181)	1.96912495
75	Primitive neuroectodermal tumor (HP:0030065)	1.96232446
76	Neuroblastic tumors (HP:0004376)	1.96232446
77	Peripheral primitive neuroectodermal neoplasm (HP:0030067)	1.96232446
78	Neuroblastoma (HP:0003006)	1.96232446
79	Clubbing of toes (HP:0100760)	1.95770705
80	Reduced antithrombin III activity (HP:0001976)	1.95260148
81	Neoplasm of the oral cavity (HP:0100649)	1.93690699
82	Focal motor seizures (HP:0011153)	1.90625384
83	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89466455
84	Respiratory difficulties (HP:0002880)	1.89389193
85	Adrenal hypoplasia (HP:0000835)	1.87924276
86	Pendular nystagmus (HP:0012043)	1.87038664
87	Renal Fanconi syndrome (HP:0001994)	1.86563472
88	Short tibia (HP:0005736)	1.86416055
89	Lactic acidosis (HP:0003128)	1.86090081
90	Abnormal protein N-linked glycosylation (HP:0012347)	1.84603445
91	Abnormal protein glycosylation (HP:0012346)	1.84603445
92	Abnormal glycosylation (HP:0012345)	1.84603445
93	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.84603445
94	Abolished electroretinogram (ERG) (HP:0000550)	1.84445817
95	Hypoproteinemia (HP:0003075)	1.84358893
96	Pancytopenia (HP:0001876)	1.82203759
97	Lethargy (HP:0001254)	1.82141347
98	Basal cell carcinoma (HP:0002671)	1.80479036
99	Premature ovarian failure (HP:0008209)	1.80395238
100	Abnormal spermatogenesis (HP:0008669)	1.79618961

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	4.00398084
2	TXK	3.89518052
3	MAP4K2	3.48376681
4	EIF2AK1	3.07714329
5	TLK1	3.03507552
6	EIF2AK3	2.80717176
7	FRK	2.50728867
8	ZAK	2.37635635
9	MKNK2	2.27551157
10	SRPK1	2.15910773
11	NUAK1	2.13342876
12	MST4	2.10302768
13	TIE1	2.06831563
14	VRK2	2.00444454
15	PHKG2	1.96826454
16	PHKG1	1.96826454
17	WNK4	1.92496836
18	ADRBK2	1.79888307
19	GRK1	1.64797943
20	PAK4	1.51891668
21	MAP3K14	1.48651783
22	BMPR1B	1.48570251
23	TAOK3	1.47986741
24	NEK1	1.41861731
25	STK16	1.41557000
26	TRIM28	1.39454100
27	MKNK1	1.39253320
28	STK39	1.39208159
29	EIF2AK2	1.35981157
30	ACVR1B	1.35154984
31	BCKDK	1.34308948
32	OXSR1	1.32736814
33	IKBKE	1.18748490
34	BUB1	1.17023527
35	PBK	1.12764041
36	MAPKAPK3	1.08469834
37	TEC	1.07720764
38	PLK3	1.07406192
39	DAPK2	1.06853753
40	MAPK13	1.05743527
41	PLK2	0.99362911
42	KIT	0.94336501
43	CSNK1G2	0.91248341
44	TAF1	0.90736569
45	IKBKB	0.89460329
46	VRK1	0.87865187
47	CSNK1G3	0.87740283
48	CCNB1	0.81489196
49	CSNK1A1L	0.79982361
50	INSRR	0.79971928
51	CSNK1G1	0.76777260
52	NME1	0.75637260
53	WNK3	0.74888810
54	PRKCE	0.73458225
55	BCR	0.72736408
56	MAP2K6	0.68459402
57	TGFBR1	0.67788502
58	DAPK1	0.66047582
59	RPS6KA5	0.63797310
60	ALK	0.61050315
61	PLK1	0.58734272
62	PLK4	0.57591960
63	LIMK1	0.55916880
64	DYRK2	0.55350166
65	PAK6	0.53476504
66	TNIK	0.52220678
67	RPS6KA4	0.49232977
68	JAK3	0.47795929
69	MAP2K2	0.47533358
70	CDK8	0.47398529
71	OBSCN	0.47043933
72	MAP3K12	0.47009220
73	ITK	0.46460373
74	ADRBK1	0.45573660
75	PASK	0.44961238
76	CASK	0.44161858
77	FES	0.43333197
78	CSNK1D	0.42827553
79	BRD4	0.42805923
80	PRKCQ	0.42626149
81	TTK	0.42255081
82	ATR	0.41085600
83	IRAK1	0.39781527
84	ATM	0.39455856
85	PRKCG	0.38982068
86	SIK3	0.38099152
87	MAPKAPK5	0.36698498
88	SYK	0.36681396
89	LCK	0.35191064
90	CSNK2A2	0.34572068
91	CAMK2A	0.33789253
92	IGF1R	0.33547871
93	CSNK2A1	0.31311819
94	PIK3CA	0.30820919
95	CSNK1A1	0.30239843
96	PAK3	0.29994934
97	PIK3CG	0.29552279
98	CAMK2G	0.29484836
99	CAMK2D	0.29145941
100	DYRK3	0.29020410

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.29768745
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.88223292
3	One carbon pool by folate_Homo sapiens_hsa00670	2.84335130
4	RNA polymerase_Homo sapiens_hsa03020	2.71511254
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.22639429
6	Homologous recombination_Homo sapiens_hsa03440	2.22365764
7	Mismatch repair_Homo sapiens_hsa03430	2.19648545
8	RNA degradation_Homo sapiens_hsa03018	2.14605917
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.11388090
10	Parkinsons disease_Homo sapiens_hsa05012	2.09179793
11	Phototransduction_Homo sapiens_hsa04744	1.95926492
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.91316394
13	Propanoate metabolism_Homo sapiens_hsa00640	1.84366536
14	Sulfur metabolism_Homo sapiens_hsa00920	1.81026537
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80057328
16	Spliceosome_Homo sapiens_hsa03040	1.78038545
17	Protein export_Homo sapiens_hsa03060	1.75714288
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.68165353
19	Asthma_Homo sapiens_hsa05310	1.63571071
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.63282314
21	Basal transcription factors_Homo sapiens_hsa03022	1.62901432
22	RNA transport_Homo sapiens_hsa03013	1.56001131
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.53727415
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.49096666
25	Huntingtons disease_Homo sapiens_hsa05016	1.45365381
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.44881851
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.40682042
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39705977
29	Allograft rejection_Homo sapiens_hsa05330	1.35735080
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.34607885
31	Nicotine addiction_Homo sapiens_hsa05033	1.33941146
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.32022489
33	Olfactory transduction_Homo sapiens_hsa04740	1.26262562
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.25821475
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.24722036
36	Peroxisome_Homo sapiens_hsa04146	1.23963588
37	Alzheimers disease_Homo sapiens_hsa05010	1.23517485
38	Butanoate metabolism_Homo sapiens_hsa00650	1.23229067
39	Purine metabolism_Homo sapiens_hsa00230	1.16468287
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16084943
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.15088066
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.10884941
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.10297512
44	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08920908
45	Primary immunodeficiency_Homo sapiens_hsa05340	1.06193994
46	Ribosome_Homo sapiens_hsa03010	1.05533227
47	Pyruvate metabolism_Homo sapiens_hsa00620	1.01199886
48	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.97908339
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.95057054
50	Nucleotide excision repair_Homo sapiens_hsa03420	0.92308829
51	Caffeine metabolism_Homo sapiens_hsa00232	0.91955084
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.90928362
53	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.90547445
54	Type I diabetes mellitus_Homo sapiens_hsa04940	0.90174349
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88718290
56	Taste transduction_Homo sapiens_hsa04742	0.88664003
57	Fatty acid elongation_Homo sapiens_hsa00062	0.87701844
58	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.87147898
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.86592880
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81858602
61	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.77638496
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76264341
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.73055360
64	Base excision repair_Homo sapiens_hsa03410	0.72605530
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.71158795
66	Graft-versus-host disease_Homo sapiens_hsa05332	0.70955690
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.67232449
68	Morphine addiction_Homo sapiens_hsa05032	0.67126272
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64432579
70	Antigen processing and presentation_Homo sapiens_hsa04612	0.64039949
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63682863
72	Metabolic pathways_Homo sapiens_hsa01100	0.59798916
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59172536
74	DNA replication_Homo sapiens_hsa03030	0.58951077
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58631048
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57594973
77	Circadian rhythm_Homo sapiens_hsa04710	0.56046673
78	Regulation of autophagy_Homo sapiens_hsa04140	0.54408164
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53747210
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53597269
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53356911
82	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.51653211
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49928913
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45684567
85	Retinol metabolism_Homo sapiens_hsa00830	0.44290127
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42290981
87	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.40657230
88	Fatty acid degradation_Homo sapiens_hsa00071	0.39101431
89	GABAergic synapse_Homo sapiens_hsa04727	0.38978439
90	Carbon metabolism_Homo sapiens_hsa01200	0.38506835
91	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.37880346
92	Serotonergic synapse_Homo sapiens_hsa04726	0.36684933
93	mRNA surveillance pathway_Homo sapiens_hsa03015	0.36483728
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36048894
95	Salivary secretion_Homo sapiens_hsa04970	0.34333141
96	Selenocompound metabolism_Homo sapiens_hsa00450	0.34221126
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.33584114
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.33328149
99	Glutathione metabolism_Homo sapiens_hsa00480	0.31182804
100	Folate biosynthesis_Homo sapiens_hsa00790	0.31135029

HSP90AB6P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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