ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.64899512
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.35116242
3	DNA deamination (GO:0045006)	3.89487394
4	fucose catabolic process (GO:0019317)	3.77695983
5	L-fucose metabolic process (GO:0042354)	3.77695983
6	L-fucose catabolic process (GO:0042355)	3.77695983
7	response to pheromone (GO:0019236)	3.76037959
8	respiratory chain complex IV assembly (GO:0008535)	3.73014800
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.69554039
10	gamma-aminobutyric acid transport (GO:0015812)	3.65896519
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.65490108
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.65490108
13	NADH dehydrogenase complex assembly (GO:0010257)	3.65490108
14	protein complex biogenesis (GO:0070271)	3.61481235
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.59018266
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.53030049
17	ATP synthesis coupled proton transport (GO:0015986)	3.53030049
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.47575596
19	mitochondrial respiratory chain complex assembly (GO:0033108)	3.47084589
20	protein polyglutamylation (GO:0018095)	3.40312296
21	platelet dense granule organization (GO:0060155)	3.29254405
22	cytochrome complex assembly (GO:0017004)	3.25114153
23	negative regulation of telomere maintenance (GO:0032205)	3.22882591
24	protein neddylation (GO:0045116)	3.18473298
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.17321621
26	nonmotile primary cilium assembly (GO:0035058)	3.12325724
27	kynurenine metabolic process (GO:0070189)	3.11472405
28	indole-containing compound catabolic process (GO:0042436)	3.06512641
29	indolalkylamine catabolic process (GO:0046218)	3.06512641
30	tryptophan catabolic process (GO:0006569)	3.06512641
31	piRNA metabolic process (GO:0034587)	3.03843946
32	protein-cofactor linkage (GO:0018065)	3.03275472
33	somite development (GO:0061053)	3.01440977
34	reflex (GO:0060004)	3.01199318
35	regulation of cilium movement (GO:0003352)	2.97458909
36	regulation of action potential (GO:0098900)	2.93743150
37	cell proliferation in forebrain (GO:0021846)	2.92754247
38	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.91200097
39	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.90972137
40	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.90972137
41	sulfation (GO:0051923)	2.89380840
42	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.87194233
43	indolalkylamine metabolic process (GO:0006586)	2.87117694
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.85551654
45	electron transport chain (GO:0022900)	2.81816370
46	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.81375335
47	cell wall macromolecule catabolic process (GO:0016998)	2.79458977
48	rhodopsin mediated signaling pathway (GO:0016056)	2.79026165
49	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.78199142
50	termination of RNA polymerase III transcription (GO:0006386)	2.78199142
51	transmission of nerve impulse (GO:0019226)	2.76797980
52	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.75983575
53	respiratory electron transport chain (GO:0022904)	2.74994035
54	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.70680139
55	startle response (GO:0001964)	2.70120647
56	pyrimidine nucleobase catabolic process (GO:0006208)	2.70041675
57	tryptophan metabolic process (GO:0006568)	2.68891301
58	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.67900578
59	adaptation of signaling pathway (GO:0023058)	2.67162401
60	synaptic transmission, cholinergic (GO:0007271)	2.67126862
61	chaperone-mediated protein transport (GO:0072321)	2.66555813
62	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.65529023
63	intracellular protein transmembrane import (GO:0044743)	2.65175437
64	cellular ketone body metabolic process (GO:0046950)	2.65045537
65	nephron epithelium morphogenesis (GO:0072088)	2.64509843
66	nephron tubule morphogenesis (GO:0072078)	2.64509843
67	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.64307276
68	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.64175745
69	epithelial cilium movement (GO:0003351)	2.63887954
70	hydrogen ion transmembrane transport (GO:1902600)	2.63857737
71	preassembly of GPI anchor in ER membrane (GO:0016254)	2.60515573
72	tRNA processing (GO:0008033)	2.57941957
73	neuronal action potential (GO:0019228)	2.57696790
74	proton transport (GO:0015992)	2.56729340
75	axoneme assembly (GO:0035082)	2.56716358
76	cilium organization (GO:0044782)	2.56545344
77	cilium morphogenesis (GO:0060271)	2.55851806
78	cell wall macromolecule metabolic process (GO:0044036)	2.54675518
79	DNA methylation involved in gamete generation (GO:0043046)	2.53878021
80	hydrogen transport (GO:0006818)	2.53695424
81	replication fork processing (GO:0031297)	2.48590643
82	cilium assembly (GO:0042384)	2.48037326
83	protein K6-linked ubiquitination (GO:0085020)	2.47063380
84	positive regulation of fatty acid transport (GO:2000193)	2.46693857
85	regulation of microtubule-based movement (GO:0060632)	2.46179535
86	negative regulation of mast cell activation (GO:0033004)	2.46086334
87	indole-containing compound metabolic process (GO:0042430)	2.41693087
88	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.39695032
89	behavioral response to ethanol (GO:0048149)	2.39233482
90	negative regulation of astrocyte differentiation (GO:0048712)	2.39213708
91	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.39098160
92	ubiquinone biosynthetic process (GO:0006744)	2.38706917
93	pseudouridine synthesis (GO:0001522)	2.38521139
94	recombinational repair (GO:0000725)	2.37426897
95	amino acid salvage (GO:0043102)	2.37070109
96	L-methionine salvage (GO:0071267)	2.37070109
97	L-methionine biosynthetic process (GO:0071265)	2.37070109
98	amine catabolic process (GO:0009310)	2.35932672
99	cellular biogenic amine catabolic process (GO:0042402)	2.35932672
100	double-strand break repair via homologous recombination (GO:0000724)	2.35782839

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68289726
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.38999013
3	VDR_22108803_ChIP-Seq_LS180_Human	3.35628210
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.58933234
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54227477
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.49320586
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.46167575
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37802987
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.24087743
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.21127225
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.18486366
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18278002
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.18196409
14	FUS_26573619_Chip-Seq_HEK293_Human	2.15346882
15	EWS_26573619_Chip-Seq_HEK293_Human	2.13521661
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.12882486
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12124958
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08462704
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.00568260
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.92547956
21	P300_19829295_ChIP-Seq_ESCs_Human	1.90814742
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.89561787
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.82985188
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.77035000
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75734761
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.74845628
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63473079
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.62908859
29	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.61914594
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.58580263
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.55242099
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.54655808
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54296984
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52233537
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49306115
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.44995740
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.43466956
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42284109
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39081689
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.38543038
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38143261
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.38143261
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36288159
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35413639
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35413639
46	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35261127
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34594496
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.34280856
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34280856
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.31459103
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31347555
52	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.28671714
53	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28007960
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27563253
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27563253
56	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27182027
57	VDR_23849224_ChIP-Seq_CD4+_Human	1.26943630
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25362964
59	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25099780
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25000276
61	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.24666731
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23367551
63	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.22620130
64	AR_25329375_ChIP-Seq_VCAP_Human	1.21801457
65	STAT3_23295773_ChIP-Seq_U87_Human	1.21220307
66	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.21166078
67	NCOR_22424771_ChIP-Seq_293T_Human	1.20190640
68	TCF4_23295773_ChIP-Seq_U87_Human	1.19868791
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.18632815
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.18624537
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.18390937
72	SMAD4_21799915_ChIP-Seq_A2780_Human	1.18330419
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16350745
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14024636
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13688371
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13139880
77	AR_21572438_ChIP-Seq_LNCaP_Human	1.12730708
78	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.10995131
79	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.10822920
80	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09047074
81	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.07170359
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05250960
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04946511
84	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.03984366
85	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03770490
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03142222
87	AR_20517297_ChIP-Seq_VCAP_Human	1.02553243
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02412045
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01868018
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01071268
91	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.00716925
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00463441
93	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.98728269
94	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97250707
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95396351
96	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.95308459
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94779654
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.93702122
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93156110
100	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92975018

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.44002930
2	MP0006292_abnormal_olfactory_placode	2.95606258
3	MP0003136_yellow_coat_color	2.52678684
4	MP0000569_abnormal_digit_pigmentation	2.50846547
5	MP0003787_abnormal_imprinting	2.47954927
6	MP0002102_abnormal_ear_morphology	2.29154571
7	MP0005551_abnormal_eye_electrophysiolog	2.24908266
8	MP0002653_abnormal_ependyma_morphology	2.24687373
9	MP0004885_abnormal_endolymph	2.23193844
10	MP0001968_abnormal_touch/_nociception	2.20747635
11	MP0003195_calcinosis	2.16617323
12	MP0008872_abnormal_physiological_respon	2.08920856
13	MP0003011_delayed_dark_adaptation	2.03256444
14	MP0002736_abnormal_nociception_after	2.00378635
15	MP0002837_dystrophic_cardiac_calcinosis	1.97062492
16	MP0002638_abnormal_pupillary_reflex	1.92983712
17	MP0004142_abnormal_muscle_tone	1.92691649
18	MP0002938_white_spotting	1.90175310
19	MP0009745_abnormal_behavioral_response	1.87953356
20	MP0006072_abnormal_retinal_apoptosis	1.85470679
21	MP0002272_abnormal_nervous_system	1.83834385
22	MP0001485_abnormal_pinna_reflex	1.83350837
23	MP0004133_heterotaxia	1.82362229
24	MP0005084_abnormal_gallbladder_morpholo	1.79733060
25	MP0005646_abnormal_pituitary_gland	1.77929887
26	MP0003646_muscle_fatigue	1.77568740
27	MP0006276_abnormal_autonomic_nervous	1.76632253
28	MP0009046_muscle_twitch	1.74467323
29	MP0002876_abnormal_thyroid_physiology	1.69832224
30	MP0000372_irregular_coat_pigmentation	1.67804412
31	MP0004742_abnormal_vestibular_system	1.67620700
32	MP0000631_abnormal_neuroendocrine_gland	1.63731146
33	MP0005645_abnormal_hypothalamus_physiol	1.53196014
34	MP0002735_abnormal_chemical_nociception	1.51222858
35	MP0005174_abnormal_tail_pigmentation	1.50918343
36	MP0001486_abnormal_startle_reflex	1.49569916
37	MP0003880_abnormal_central_pattern	1.47598550
38	MP0002733_abnormal_thermal_nociception	1.46197761
39	MP0008875_abnormal_xenobiotic_pharmacok	1.45873349
40	MP0001529_abnormal_vocalization	1.44458131
41	MP0005253_abnormal_eye_physiology	1.44353230
42	MP0001986_abnormal_taste_sensitivity	1.42956695
43	MP0004147_increased_porphyrin_level	1.41970726
44	MP0001970_abnormal_pain_threshold	1.36685418
45	MP0002160_abnormal_reproductive_system	1.35586888
46	MP0001984_abnormal_olfaction	1.33646702
47	MP0001293_anophthalmia	1.33302668
48	MP0003122_maternal_imprinting	1.32465651
49	MP0002572_abnormal_emotion/affect_behav	1.30534418
50	MP0002064_seizures	1.29666219
51	MP0008789_abnormal_olfactory_epithelium	1.29491125
52	MP0002138_abnormal_hepatobiliary_system	1.28092288
53	MP0003121_genomic_imprinting	1.24307386
54	MP0005389_reproductive_system_phenotype	1.23346123
55	MP0004145_abnormal_muscle_electrophysio	1.22989323
56	MP0000778_abnormal_nervous_system	1.22401608
57	MP0000427_abnormal_hair_cycle	1.17610439
58	MP0001440_abnormal_grooming_behavior	1.17118471
59	MP0004043_abnormal_pH_regulation	1.15915042
60	MP0002557_abnormal_social/conspecific_i	1.14398596
61	MP0002277_abnormal_respiratory_mucosa	1.14299231
62	MP0005075_abnormal_melanosome_morpholog	1.13940514
63	MP0001501_abnormal_sleep_pattern	1.13746211
64	MP0002063_abnormal_learning/memory/cond	1.11045539
65	MP0003718_maternal_effect	1.10112164
66	MP0001919_abnormal_reproductive_system	1.10043309
67	MP0002734_abnormal_mechanical_nocicepti	1.08971275
68	MP0002928_abnormal_bile_duct	1.08661767
69	MP0000026_abnormal_inner_ear	1.08279595
70	MP0002095_abnormal_skin_pigmentation	1.07925637
71	MP0001905_abnormal_dopamine_level	1.07644595
72	MP0002067_abnormal_sensory_capabilities	1.07500846
73	MP0005195_abnormal_posterior_eye	1.05802239
74	MP0003635_abnormal_synaptic_transmissio	1.04669953
75	MP0008058_abnormal_DNA_repair	1.04666753
76	MP0000049_abnormal_middle_ear	1.01592505
77	MP0002752_abnormal_somatic_nervous	0.98146274
78	MP0001963_abnormal_hearing_physiology	0.93977271
79	MP0003938_abnormal_ear_development	0.91840400
80	MP0003283_abnormal_digestive_organ	0.91363177
81	MP0005386_behavior/neurological_phenoty	0.88802363
82	MP0004924_abnormal_behavior	0.88802363
83	MP0005085_abnormal_gallbladder_physiolo	0.86677689
84	MP0005410_abnormal_fertilization	0.85672550
85	MP0002184_abnormal_innervation	0.84601664
86	MP0009379_abnormal_foot_pigmentation	0.83637468
87	MP0001324_abnormal_eye_pigmentation	0.82716748
88	MP0003937_abnormal_limbs/digits/tail_de	0.82097517
89	MP0002751_abnormal_autonomic_nervous	0.80957218
90	MP0008995_early_reproductive_senescence	0.80233473
91	MP0000230_abnormal_systemic_arterial	0.77940974
92	MP0003698_abnormal_male_reproductive	0.77850726
93	MP0002234_abnormal_pharynx_morphology	0.76479878
94	MP0002254_reproductive_system_inflammat	0.76172472
95	MP0003890_abnormal_embryonic-extraembry	0.75856503
96	MP0002210_abnormal_sex_determination	0.75343147
97	MP0002229_neurodegeneration	0.74776232
98	MP0005499_abnormal_olfactory_system	0.74770293
99	MP0005394_taste/olfaction_phenotype	0.74770293
100	MP0010386_abnormal_urinary_bladder	0.74497741

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.71514615
2	Abnormality of midbrain morphology (HP:0002418)	4.60380422
3	Molar tooth sign on MRI (HP:0002419)	4.60380422
4	Pancreatic fibrosis (HP:0100732)	4.40935500
5	True hermaphroditism (HP:0010459)	4.35500333
6	Nephronophthisis (HP:0000090)	4.18963691
7	Congenital stationary night blindness (HP:0007642)	3.67241192
8	Abnormality of the renal medulla (HP:0100957)	3.42970118
9	Pendular nystagmus (HP:0012043)	3.15729158
10	Chronic hepatic failure (HP:0100626)	3.02747114
11	Medial flaring of the eyebrow (HP:0010747)	2.90571154
12	Sclerocornea (HP:0000647)	2.85362008
13	Abolished electroretinogram (ERG) (HP:0000550)	2.84968398
14	Cystic liver disease (HP:0006706)	2.80978433
15	Acute necrotizing encephalopathy (HP:0006965)	2.77243312
16	Abnormal rod and cone electroretinograms (HP:0008323)	2.74009713
17	Abnormality of the renal cortex (HP:0011035)	2.71921229
18	Mitochondrial inheritance (HP:0001427)	2.70754027
19	3-Methylglutaconic aciduria (HP:0003535)	2.65802918
20	Increased CSF lactate (HP:0002490)	2.64986550
21	Congenital, generalized hypertrichosis (HP:0004540)	2.56428081
22	Anencephaly (HP:0002323)	2.53674740
23	Furrowed tongue (HP:0000221)	2.52880397
24	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.51361775
25	Abnormality of alanine metabolism (HP:0010916)	2.50953118
26	Hyperalaninemia (HP:0003348)	2.50953118
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.50953118
28	Abnormality of the labia minora (HP:0012880)	2.50788334
29	Focal motor seizures (HP:0011153)	2.48107921
30	Attenuation of retinal blood vessels (HP:0007843)	2.48012886
31	Acute encephalopathy (HP:0006846)	2.46583032
32	Lipid accumulation in hepatocytes (HP:0006561)	2.46161354
33	Keratoconus (HP:0000563)	2.45787612
34	Increased corneal curvature (HP:0100692)	2.45787612
35	Inability to walk (HP:0002540)	2.45147705
36	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.41104901
37	Methylmalonic acidemia (HP:0002912)	2.39699290
38	Increased hepatocellular lipid droplets (HP:0006565)	2.39408264
39	Type II lissencephaly (HP:0007260)	2.36379554
40	Progressive inability to walk (HP:0002505)	2.36237409
41	Concave nail (HP:0001598)	2.36188453
42	Progressive macrocephaly (HP:0004481)	2.35480781
43	Decreased central vision (HP:0007663)	2.32641663
44	Congenital hepatic fibrosis (HP:0002612)	2.32231499
45	Hepatocellular necrosis (HP:0001404)	2.31989832
46	Abnormal mitochondria in muscle tissue (HP:0008316)	2.30522678
47	Abnormal biliary tract physiology (HP:0012439)	2.29645034
48	Bile duct proliferation (HP:0001408)	2.29645034
49	Hyperventilation (HP:0002883)	2.29327776
50	Gait imbalance (HP:0002141)	2.24109208
51	Male pseudohermaphroditism (HP:0000037)	2.21961594
52	Polydipsia (HP:0001959)	2.19405961
53	Abnormal drinking behavior (HP:0030082)	2.19405961
54	Tubular atrophy (HP:0000092)	2.14470593
55	Progressive cerebellar ataxia (HP:0002073)	2.12851545
56	Septo-optic dysplasia (HP:0100842)	2.11288515
57	Methylmalonic aciduria (HP:0012120)	2.11041333
58	Optic disc pallor (HP:0000543)	2.09994942
59	Postaxial foot polydactyly (HP:0001830)	2.09169282
60	Large for gestational age (HP:0001520)	2.08884685
61	Congenital primary aphakia (HP:0007707)	2.06189155
62	Rib fusion (HP:0000902)	2.06173252
63	Hyperglycinemia (HP:0002154)	2.05732450
64	Renal cortical cysts (HP:0000803)	2.01396724
65	Hepatic necrosis (HP:0002605)	2.01128237
66	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.97984909
67	Absent/shortened dynein arms (HP:0200106)	1.97219594
68	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.97219594
69	Hypoplasia of the pons (HP:0012110)	1.95629519
70	Increased serum lactate (HP:0002151)	1.94530440
71	Chorioretinal atrophy (HP:0000533)	1.92367788
72	Broad-based gait (HP:0002136)	1.90694532
73	Optic nerve hypoplasia (HP:0000609)	1.90659637
74	Nephrogenic diabetes insipidus (HP:0009806)	1.89296886
75	Abnormality of the pons (HP:0007361)	1.88730328
76	Abnormal number of erythroid precursors (HP:0012131)	1.88636362
77	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.86939546
78	Genital tract atresia (HP:0001827)	1.84460390
79	Oligodactyly (hands) (HP:0001180)	1.83801718
80	Polyuria (HP:0000103)	1.83586508
81	Abnormal respiratory epithelium morphology (HP:0012253)	1.83233907
82	Abnormal respiratory motile cilium morphology (HP:0005938)	1.83233907
83	Vaginal atresia (HP:0000148)	1.82088896
84	Lissencephaly (HP:0001339)	1.81584995
85	Aplasia/Hypoplasia of the patella (HP:0006498)	1.80977838
86	Hyperglycinuria (HP:0003108)	1.80537158
87	Patellar aplasia (HP:0006443)	1.79760821
88	Renal Fanconi syndrome (HP:0001994)	1.78530249
89	Hemiparesis (HP:0001269)	1.78062953
90	Abnormality of serum amino acid levels (HP:0003112)	1.76931010
91	Fair hair (HP:0002286)	1.76594791
92	Gaze-evoked nystagmus (HP:0000640)	1.76573776
93	Colon cancer (HP:0003003)	1.76237167
94	Dialeptic seizures (HP:0011146)	1.74736819
95	Genetic anticipation (HP:0003743)	1.74615276
96	Bony spicule pigmentary retinopathy (HP:0007737)	1.73937444
97	Occipital encephalocele (HP:0002085)	1.72651687
98	Postaxial hand polydactyly (HP:0001162)	1.71594298
99	Clumsiness (HP:0002312)	1.71456961
100	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.69905295

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.73513315
2	MAP4K2	3.07758835
3	ADRBK2	3.03618104
4	PINK1	2.83246894
5	WNK4	2.81700666
6	BMPR1B	2.73282742
7	WNK3	2.52422714
8	NUAK1	2.46144329
9	ZAK	2.41713100
10	GRK1	2.38584777
11	INSRR	2.03319662
12	VRK2	1.91259254
13	ACVR1B	1.91166694
14	CASK	1.91113255
15	MKNK2	1.75770052
16	TLK1	1.71065742
17	TNIK	1.69772024
18	STK39	1.69105315
19	DYRK2	1.62177239
20	TXK	1.61163740
21	OXSR1	1.51708256
22	MAPK13	1.51640239
23	TAOK3	1.49901182
24	MARK1	1.44523016
25	MAP3K4	1.43108052
26	CAMKK2	1.41685288
27	VRK1	1.37451168
28	MST4	1.34532384
29	PNCK	1.28205190
30	TRIM28	1.25942746
31	PAK3	1.25383839
32	NME1	1.22296093
33	STK38L	1.13503074
34	PRKCG	1.12187055
35	DAPK2	1.04496246
36	ADRBK1	1.01129605
37	MAP2K7	1.00908591
38	TIE1	0.98649545
39	PLK3	0.97639916
40	TAF1	0.96980221
41	PHKG2	0.93968107
42	PHKG1	0.93968107
43	BCKDK	0.93854970
44	MAP2K6	0.92606796
45	MKNK1	0.92359525
46	STK16	0.91922742
47	PLK4	0.91792888
48	PLK2	0.88855027
49	CSNK1G1	0.88454980
50	TGFBR1	0.84286236
51	PRKCE	0.80158447
52	CDC7	0.79442013
53	CSNK1G2	0.79202195
54	NEK1	0.76369178
55	PRKCI	0.73443806
56	CSNK1G3	0.72726950
57	PTK2B	0.71577750
58	BUB1	0.70111838
59	TSSK6	0.65100085
60	NTRK2	0.64824621
61	NTRK3	0.63868697
62	MUSK	0.61393597
63	BCR	0.60244740
64	SIK2	0.59975622
65	BRSK2	0.59238288
66	WEE1	0.58602324
67	TEC	0.58570204
68	MAPK15	0.58537570
69	PRKCQ	0.58186359
70	EPHB2	0.56167323
71	STK11	0.55382940
72	EIF2AK3	0.55295716
73	CSNK1A1L	0.53917587
74	IKBKB	0.50838865
75	RPS6KA5	0.50631466
76	PRKACA	0.46409313
77	WNK1	0.45151492
78	CAMK1	0.44962128
79	FGFR2	0.44666915
80	PRKCZ	0.44520898
81	PLK1	0.43867745
82	MAP3K12	0.43233928
83	PKN1	0.43074510
84	CAMK2A	0.42284033
85	DYRK3	0.40861956
86	CCNB1	0.39877202
87	ATR	0.39123804
88	CAMKK1	0.39008274
89	MAPKAPK5	0.38962674
90	NLK	0.38674103
91	SRPK1	0.38563614
92	PIK3CA	0.38313315
93	CSNK1A1	0.37609589
94	PRKCH	0.36511443
95	ITK	0.36202391
96	PDK2	0.35005022
97	CDK19	0.34726004
98	MINK1	0.32777418
99	CHEK2	0.32095936
100	CSNK1D	0.31010117

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.23449571
2	Phototransduction_Homo sapiens_hsa04744	2.89971252
3	RNA polymerase_Homo sapiens_hsa03020	2.57293010
4	Parkinsons disease_Homo sapiens_hsa05012	2.53176089
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.41223734
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.30528814
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.17092184
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.15095927
9	Protein export_Homo sapiens_hsa03060	2.13136258
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.12329198
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.06014697
12	Nicotine addiction_Homo sapiens_hsa05033	2.00352168
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.99981981
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.95483051
15	Homologous recombination_Homo sapiens_hsa03440	1.93584704
16	Butanoate metabolism_Homo sapiens_hsa00650	1.81291784
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.80927499
18	Huntingtons disease_Homo sapiens_hsa05016	1.79044073
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.77600247
20	Basal transcription factors_Homo sapiens_hsa03022	1.76037306
21	Proteasome_Homo sapiens_hsa03050	1.74088317
22	Ribosome_Homo sapiens_hsa03010	1.71904360
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.69811522
24	Alzheimers disease_Homo sapiens_hsa05010	1.66047712
25	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.64569150
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.54539979
27	One carbon pool by folate_Homo sapiens_hsa00670	1.51404277
28	Caffeine metabolism_Homo sapiens_hsa00232	1.50388507
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.50157300
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.46241801
31	RNA degradation_Homo sapiens_hsa03018	1.46182908
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39423616
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.29092160
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.25625044
35	Olfactory transduction_Homo sapiens_hsa04740	1.25555194
36	Peroxisome_Homo sapiens_hsa04146	1.21241832
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.20157120
38	Propanoate metabolism_Homo sapiens_hsa00640	1.20098343
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.17417817
40	Taste transduction_Homo sapiens_hsa04742	1.12821657
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.11823556
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07826762
43	Non-homologous end-joining_Homo sapiens_hsa03450	1.07162259
44	Morphine addiction_Homo sapiens_hsa05032	1.06997290
45	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.04835755
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04268118
47	Steroid biosynthesis_Homo sapiens_hsa00100	0.98748028
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.95086503
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93319611
50	Purine metabolism_Homo sapiens_hsa00230	0.93100875
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86910049
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.86232396
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.86019523
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83406750
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.82102544
56	GABAergic synapse_Homo sapiens_hsa04727	0.81485217
57	Retinol metabolism_Homo sapiens_hsa00830	0.81321973
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.79763680
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.78902453
60	Regulation of autophagy_Homo sapiens_hsa04140	0.78859065
61	Insulin secretion_Homo sapiens_hsa04911	0.78248608
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.76876677
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76101497
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75909959
65	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.75514703
66	Serotonergic synapse_Homo sapiens_hsa04726	0.73588459
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.70530608
68	Primary immunodeficiency_Homo sapiens_hsa05340	0.69884817
69	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.68546984
70	Metabolic pathways_Homo sapiens_hsa01100	0.68090011
71	Circadian entrainment_Homo sapiens_hsa04713	0.67002742
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66310624
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65487188
74	ABC transporters_Homo sapiens_hsa02010	0.64393815
75	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59580694
76	Sulfur relay system_Homo sapiens_hsa04122	0.59198468
77	RNA transport_Homo sapiens_hsa03013	0.57386557
78	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.57159783
79	Asthma_Homo sapiens_hsa05310	0.55983903
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55651341
81	Sulfur metabolism_Homo sapiens_hsa00920	0.55355085
82	Salivary secretion_Homo sapiens_hsa04970	0.48978697
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48173549
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46848745
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.45424954
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44306558
87	Nucleotide excision repair_Homo sapiens_hsa03420	0.43956585
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43340235
89	Mismatch repair_Homo sapiens_hsa03430	0.40555990
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40443607
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39172333
92	Base excision repair_Homo sapiens_hsa03410	0.37618303
93	Mineral absorption_Homo sapiens_hsa04978	0.37137295
94	Spliceosome_Homo sapiens_hsa03040	0.35970297
95	Cocaine addiction_Homo sapiens_hsa05030	0.34488322
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.34317295
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.31751362
98	Fatty acid degradation_Homo sapiens_hsa00071	0.31738700
99	Basal cell carcinoma_Homo sapiens_hsa05217	0.31336146
100	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.29248898

HSP90AB7P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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