HSP90B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)9.55232154
2COPI coating of Golgi vesicle (GO:0048205)9.55232154
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.63826270
4COPII vesicle coating (GO:0048208)6.03980553
5* activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.79378261
6* positive regulation of nuclease activity (GO:0032075)5.62705238
7ER overload response (GO:0006983)5.47553333
8protein retention in ER lumen (GO:0006621)5.43093360
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.24842153
10* regulation of nuclease activity (GO:0032069)5.18618933
11* endoplasmic reticulum unfolded protein response (GO:0030968)5.12794595
12* cellular response to unfolded protein (GO:0034620)4.95165269
13protein maturation by protein folding (GO:0022417)4.80025809
14* ER-nucleus signaling pathway (GO:0006984)4.74328078
15* cellular response to topologically incorrect protein (GO:0035967)4.61925713
16vesicle coating (GO:0006901)4.56554950
17exocrine pancreas development (GO:0031017)4.54895116
18signal peptide processing (GO:0006465)4.48183286
19* response to endoplasmic reticulum stress (GO:0034976)4.28568205
20apoptotic cell clearance (GO:0043277)4.08515325
21* ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.06941716
22* response to unfolded protein (GO:0006986)4.00726432
23mitotic chromosome condensation (GO:0007076)3.88822948
24protein N-linked glycosylation via asparagine (GO:0018279)3.88603879
25peptidyl-asparagine modification (GO:0018196)3.86815060
26* response to topologically incorrect protein (GO:0035966)3.79386301
27paraxial mesoderm development (GO:0048339)3.79167898
284-hydroxyproline metabolic process (GO:0019471)3.75636101
29DNA unwinding involved in DNA replication (GO:0006268)3.71072595
30glucocorticoid receptor signaling pathway (GO:0042921)3.69956067
31* sequestering of metal ion (GO:0051238)3.67974242
32hemidesmosome assembly (GO:0031581)3.59628644
33nucleotide-sugar biosynthetic process (GO:0009226)3.59551711
34cellular response to vitamin D (GO:0071305)3.58193789
35nuclear pore complex assembly (GO:0051292)3.57973989
36glomerular visceral epithelial cell development (GO:0072015)3.56578512
37protein N-linked glycosylation (GO:0006487)3.53571329
38mitotic sister chromatid segregation (GO:0000070)3.42209948
39regulation of mitotic spindle organization (GO:0060236)3.41666945
40type B pancreatic cell development (GO:0003323)3.39247738
41sister chromatid segregation (GO:0000819)3.37790828
42mitotic sister chromatid cohesion (GO:0007064)3.31625903
43regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.27693109
44nuclear pore organization (GO:0006999)3.25534489
45endocrine pancreas development (GO:0031018)3.19419859
46ribosome assembly (GO:0042255)3.19415359
47cell adhesion mediated by integrin (GO:0033627)3.15684950
48collagen fibril organization (GO:0030199)3.15278801
49glomerular epithelial cell development (GO:0072310)3.11018483
50DNA topological change (GO:0006265)3.10053589
51UDP-N-acetylglucosamine metabolic process (GO:0006047)3.07301503
52protein localization to chromosome, centromeric region (GO:0071459)3.06640224
53protein export from nucleus (GO:0006611)3.05504066
54bundle of His cell to Purkinje myocyte communication (GO:0086069)3.05324879
55mitotic nuclear envelope disassembly (GO:0007077)3.03894259
56Golgi organization (GO:0007030)3.03459846
57positive regulation of hormone biosynthetic process (GO:0046886)3.03436440
58insulin-like growth factor receptor signaling pathway (GO:0048009)3.02972482
59mitotic metaphase plate congression (GO:0007080)3.02689149
60peptide hormone processing (GO:0016486)3.01200322
61nuclear envelope disassembly (GO:0051081)2.99958243
62membrane disassembly (GO:0030397)2.99958243
63peptidyl-proline hydroxylation (GO:0019511)2.96858879
64ER to Golgi vesicle-mediated transport (GO:0006888)2.96744839
65regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.96405188
66desmosome organization (GO:0002934)2.94653753
67cellular response to vitamin (GO:0071295)2.94115425
68protein localization to kinetochore (GO:0034501)2.93631833
69regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92971713
70glandular epithelial cell development (GO:0002068)2.89540187
71regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88759355
72negative regulation of DNA repair (GO:0045738)2.85128982
73chondrocyte development (GO:0002063)2.84510938
74dorsal/ventral axis specification (GO:0009950)2.83628839
75corticosteroid receptor signaling pathway (GO:0031958)2.83229669
76mesodermal cell differentiation (GO:0048333)2.80150280
77protein hydroxylation (GO:0018126)2.78703852
78folic acid-containing compound biosynthetic process (GO:0009396)2.78100691
79regulation of RNA export from nucleus (GO:0046831)2.77470600
80proline biosynthetic process (GO:0006561)2.75013826
81establishment of integrated proviral latency (GO:0075713)2.73233150
82peptide catabolic process (GO:0043171)2.71277197
83chromosome condensation (GO:0030261)2.70139565
84formation of translation preinitiation complex (GO:0001731)2.67793030
85endothelial cell morphogenesis (GO:0001886)2.67619658
86regulation of spindle organization (GO:0090224)2.66868067
87heterochromatin organization (GO:0070828)2.64735843
88cellular response to antibiotic (GO:0071236)2.64566981
89metaphase plate congression (GO:0051310)2.63686138
90columnar/cuboidal epithelial cell development (GO:0002066)2.62746284
91branching involved in prostate gland morphogenesis (GO:0060442)2.62397396
92protein autoprocessing (GO:0016540)2.61888373
93chaperone-mediated protein folding (GO:0061077)2.61880528
94hippo signaling (GO:0035329)2.60138459
95maintenance of protein localization in organelle (GO:0072595)2.59535651
96notochord development (GO:0030903)2.59369216
97intra-Golgi vesicle-mediated transport (GO:0006891)2.59289240
98positive regulation of DNA-templated transcription, initiation (GO:2000144)2.58478505
99cellular protein complex localization (GO:0034629)2.58146219
100negative regulation of fatty acid transport (GO:2000192)2.57340610
101positive regulation of cell cycle checkpoint (GO:1901978)2.57043933
102regulation of translational fidelity (GO:0006450)2.56829169
103toxin metabolic process (GO:0009404)2.56701122
104cell redox homeostasis (GO:0045454)2.55943972
105DNA duplex unwinding (GO:0032508)2.54532884
106cytoplasmic mRNA processing body assembly (GO:0033962)2.54378194
107gap junction assembly (GO:0016264)2.53857082
108pore complex assembly (GO:0046931)2.52895362
109nuclear envelope organization (GO:0006998)2.51952221
110iron ion import (GO:0097286)2.51541423
111establishment of chromosome localization (GO:0051303)2.51315154
112regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.50661369
113regulation of glucose import in response to insulin stimulus (GO:2001273)2.50087676
114cell-substrate junction assembly (GO:0007044)2.49481043
115regulation of sister chromatid cohesion (GO:0007063)2.49159881
116endocardial cushion development (GO:0003197)2.48763146
117protein complex localization (GO:0031503)2.47553609
118cell migration involved in sprouting angiogenesis (GO:0002042)2.47264427
119chondrocyte proliferation (GO:0035988)2.46524294
120skin morphogenesis (GO:0043589)2.46432927
121regulation of centriole replication (GO:0046599)2.43422280
122maternal placenta development (GO:0001893)2.42921793
123lung vasculature development (GO:0060426)2.42826946
124cellular response to epidermal growth factor stimulus (GO:0071364)2.42253491
125body morphogenesis (GO:0010171)2.42199926
126positive regulation of osteoblast proliferation (GO:0033690)2.42081839
127nucleotide-sugar metabolic process (GO:0009225)2.41856419
128renal system development (GO:0072001)2.41365272
129intestinal epithelial cell development (GO:0060576)2.41252960
130polarized epithelial cell differentiation (GO:0030859)2.41190058
131cellular response to interferon-alpha (GO:0035457)2.40618010
132planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39487610
133regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.39478256
134DNA geometric change (GO:0032392)2.39321452
135endodermal cell differentiation (GO:0035987)2.39142187
136regulation of growth hormone secretion (GO:0060123)2.37956013
137positive regulation of SMAD protein import into nucleus (GO:0060391)2.37087663
138mitotic cytokinesis (GO:0000281)2.36793015
139glandular epithelial cell differentiation (GO:0002067)2.36312571
140response to epidermal growth factor (GO:0070849)2.35755901
141cellular response to glucose starvation (GO:0042149)2.34483915
142osteoblast differentiation (GO:0001649)2.33570087
143cerebellar Purkinje cell layer development (GO:0021680)2.32467268
144regulation of transforming growth factor beta2 production (GO:0032909)2.32451031
145negative regulation of glycogen biosynthetic process (GO:0045719)2.31823203
146regulation of DNA endoreduplication (GO:0032875)2.31618123
147regulation of nucleobase-containing compound transport (GO:0032239)2.30988264
148DNA conformation change (GO:0071103)2.30147744
149sequestering of extracellular ligand from receptor (GO:0035581)2.29726716
150basement membrane organization (GO:0071711)2.28976456
151positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.26024938
152macroautophagy (GO:0016236)2.25420386
153L-alpha-amino acid transmembrane transport (GO:1902475)2.25186622
154prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.23693968
155regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.23365569
156positive regulation of glycolytic process (GO:0045821)2.23064520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.86011185
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.75319495
3* CLOCK_20551151_ChIP-Seq_293T_Human3.75815122
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.18418134
5E2F7_22180533_ChIP-Seq_HELA_Human3.16340622
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.07079734
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.05881981
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.98413940
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.84616765
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.64125461
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.60775948
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.56792306
13ZNF263_19887448_ChIP-Seq_K562_Human2.45606582
14PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.31931577
15AR_21909140_ChIP-Seq_LNCAP_Human2.27586433
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21709151
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15431100
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13221467
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.10522829
20DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.10044677
21BRD4_25478319_ChIP-Seq_HGPS_Human1.98882949
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.97282296
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95977854
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95960300
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.95529522
26SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.94079521
27GATA1_22025678_ChIP-Seq_K562_Human1.85420231
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.79154848
29SALL4_18804426_ChIP-ChIP_XEN_Mouse1.78193513
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.77964974
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.75011676
32CHD1_26751641_Chip-Seq_LNCaP_Human1.73205322
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.73142741
34CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.72769210
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.69461187
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69216356
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67763737
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63560637
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.59297456
40TFEB_21752829_ChIP-Seq_HELA_Human1.55473599
41KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54666616
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54210436
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53105531
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52464397
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52464397
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52464397
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.52252999
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51725275
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51362727
50* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50357963
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.50298143
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49261694
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.47924410
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47434896
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.47012282
56ELK1_19687146_ChIP-ChIP_HELA_Human1.46806135
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46797428
58FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.46767780
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45781374
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44691651
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44159651
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.43060045
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42965836
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42965836
65* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41777663
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41765494
67GATA6_25053715_ChIP-Seq_YYC3_Human1.39521427
68CJUN_26792858_Chip-Seq_BT549_Human1.38874259
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38463520
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35439480
71SOX2_20726797_ChIP-Seq_SW620_Human1.35140642
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35117519
73* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34629813
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31744154
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31744154
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31618541
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30127850
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30026526
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29573078
80* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28995044
81FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27750339
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27640102
83* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26545484
84* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.26185472
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25147053
86FOXA2_19822575_ChIP-Seq_HepG2_Human1.25122701
87PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24994157
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24779672
89* DCP1A_22483619_ChIP-Seq_HELA_Human1.23671158
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23554252
91FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23067842
92GATA4_25053715_ChIP-Seq_YYC3_Human1.23030276
93* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22974820
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22915255
95GATA3_24758297_ChIP-Seq_MCF-7_Human1.22735159
96E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21470374
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20410871
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19790998
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19060753
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16715790
101* UBF1/2_26484160_Chip-Seq_HMECs_Human1.16475572
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15608658
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15368618
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14294600
105P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13447458
106KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13279026
107TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12918366
108* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12885205
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09927587
110* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09260500
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08815068
112NANOG_21062744_ChIP-ChIP_HESCs_Human1.08616941
113FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08606413
114SOX17_20123909_ChIP-Seq_XEN_Mouse1.08223920
115EP300_21415370_ChIP-Seq_HL-1_Mouse1.07724656
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07358570
117* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05854864
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05257438
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04717513
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04492764
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01901620
122CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00898987
123* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99669324
124ZNF274_21170338_ChIP-Seq_K562_Hela0.98438548
125* XRN2_22483619_ChIP-Seq_HELA_Human0.98380259
126MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97589488
127TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97189387
128ATF3_27146783_Chip-Seq_COLON_Human0.97180283
129ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96041233
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95317038
131TTF2_22483619_ChIP-Seq_HELA_Human0.94457073
132MYC_22102868_ChIP-Seq_BL_Human0.93790147
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93607847
134KDM5A_27292631_Chip-Seq_BREAST_Human0.93542587
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92974334
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92731773
137* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91947535
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.91519778
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91513743
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90431115
141TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90158697

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.46897651
2MP0002877_abnormal_melanocyte_morpholog3.32407561
3MP0003705_abnormal_hypodermis_morpholog3.28427608
4MP0006054_spinal_hemorrhage3.24256878
5MP0003941_abnormal_skin_development2.71607754
6MP0003283_abnormal_digestive_organ2.62511839
7MP0010352_gastrointestinal_tract_polyps2.55021314
8MP0004272_abnormal_basement_membrane2.54629529
9MP0003300_gastrointestinal_ulcer2.50343043
10MP0005275_abnormal_skin_tensile2.46499881
11MP0005503_abnormal_tendon_morphology2.39065523
12MP0010234_abnormal_vibrissa_follicle2.25760065
13MP0009780_abnormal_chondrocyte_physiolo2.19104348
14MP0005220_abnormal_exocrine_pancreas2.04269668
15MP0003566_abnormal_cell_adhesion2.03894050
16MP0003111_abnormal_nucleus_morphology2.01629837
17MP0004264_abnormal_extraembryonic_tissu1.97890319
18MP0002896_abnormal_bone_mineralization1.87238350
19MP0008932_abnormal_embryonic_tissue1.86734788
20MP0000013_abnormal_adipose_tissue1.85957744
21MP0010094_abnormal_chromosome_stability1.85024926
22MP0009384_cardiac_valve_regurgitation1.80761230
23MP0009053_abnormal_anal_canal1.76814464
24MP0001944_abnormal_pancreas_morphology1.75987562
25MP0000537_abnormal_urethra_morphology1.70610092
26MP0003195_calcinosis1.67732193
27MP0003950_abnormal_plasma_membrane1.65951807
28MP0008007_abnormal_cellular_replicative1.62062924
29MP0003077_abnormal_cell_cycle1.61915226
30MP0003183_abnormal_peptide_metabolism1.58915550
31MP0003122_maternal_imprinting1.57816661
32* MP0001672_abnormal_embryogenesis/_devel1.54853070
33* MP0005380_embryogenesis_phenotype1.54853070
34MP0004233_abnormal_muscle_weight1.53326577
35MP0000003_abnormal_adipose_tissue1.50454692
36MP0005623_abnormal_meninges_morphology1.50268864
37MP0008057_abnormal_DNA_replication1.48927197
38MP0003123_paternal_imprinting1.46513264
39MP0009697_abnormal_copulation1.46033858
40MP0003252_abnormal_bile_duct1.45926181
41MP0002693_abnormal_pancreas_physiology1.41717198
42MP0000350_abnormal_cell_proliferation1.41324060
43MP0000762_abnormal_tongue_morphology1.40324746
44MP0010030_abnormal_orbit_morphology1.38701718
45MP0001299_abnormal_eye_distance/1.37239309
46MP0005023_abnormal_wound_healing1.31933134
47MP0010307_abnormal_tumor_latency1.30366067
48MP0002295_abnormal_pulmonary_circulatio1.30357795
49MP0010386_abnormal_urinary_bladder1.29395342
50* MP0002080_prenatal_lethality1.27339615
51MP0005408_hypopigmentation1.25809904
52MP0000579_abnormal_nail_morphology1.25258248
53MP0000428_abnormal_craniofacial_morphol1.25030658
54MP0004197_abnormal_fetal_growth/weight/1.23963193
55* MP0002085_abnormal_embryonic_tissue1.21771642
56MP0005257_abnormal_intraocular_pressure1.20494476
57MP0005451_abnormal_body_composition1.20064682
58* MP0005076_abnormal_cell_differentiation1.19945061
59MP0002796_impaired_skin_barrier1.19880722
60MP0003453_abnormal_keratinocyte_physiol1.17373884
61MP0002009_preneoplasia1.16868227
62MP0002928_abnormal_bile_duct1.16358205
63MP0002060_abnormal_skin_morphology1.14179837
64MP0001849_ear_inflammation1.13282713
65MP0003693_abnormal_embryo_hatching1.11594143
66MP0002139_abnormal_hepatobiliary_system1.11390335
67MP0002909_abnormal_adrenal_gland1.10744875
68MP0004185_abnormal_adipocyte_glucose1.10636867
69MP0004043_abnormal_pH_regulation1.10396649
70MP0005508_abnormal_skeleton_morphology1.09047270
71MP0005058_abnormal_lysosome_morphology1.08906060
72MP0009703_decreased_birth_body1.08621243
73* MP0003890_abnormal_embryonic-extraembry1.08542268
74MP0003868_abnormal_feces_composition1.06612870
75MP0003121_genomic_imprinting1.05043546
76MP0003315_abnormal_perineum_morphology1.03865065
77MP0003091_abnormal_cell_migration1.03359042
78MP0003279_aneurysm1.02690422
79* MP0005621_abnormal_cell_physiology1.01657512
80MP0010368_abnormal_lymphatic_system1.01556861
81MP0001958_emphysema1.01429320
82MP0000462_abnormal_digestive_system1.01079119
83MP0002006_tumorigenesis1.00943437
84MP0003115_abnormal_respiratory_system1.00917558
85MP0009672_abnormal_birth_weight1.00409529
86MP0003385_abnormal_body_wall1.00178370
87MP0002168_other_aberrant_phenotype1.00039951
88MP0002396_abnormal_hematopoietic_system0.99970912
89MP0000678_abnormal_parathyroid_gland0.98579983
90MP0001216_abnormal_epidermal_layer0.98416193
91MP0010678_abnormal_skin_adnexa0.97370428
92MP0003942_abnormal_urinary_system0.97224142
93MP0005197_abnormal_uvea_morphology0.95434061
94MP0003937_abnormal_limbs/digits/tail_de0.94878591
95MP0003045_fibrosis0.93982497
96MP0000613_abnormal_salivary_gland0.93901648
97MP0000163_abnormal_cartilage_morphology0.92317527
98MP0000569_abnormal_digit_pigmentation0.91968416
99MP0005248_abnormal_Harderian_gland0.90054147
100MP0005501_abnormal_skin_physiology0.87829516
101MP0001879_abnormal_lymphatic_vessel0.87621361
102MP0000627_abnormal_mammary_gland0.87571469
103MP0000733_abnormal_muscle_development0.87096453
104* MP0002084_abnormal_developmental_patter0.86110219
105MP0002111_abnormal_tail_morphology0.85797085
106MP0001177_atelectasis0.85320641
107MP0002115_abnormal_skeleton_extremities0.85047273
108MP0002697_abnormal_eye_size0.84751466
109MP0000467_abnormal_esophagus_morphology0.84743803
110MP0005409_darkened_coat_color0.83042320
111* MP0005384_cellular_phenotype0.82913185
112MP0003935_abnormal_craniofacial_develop0.82846822
113MP0001243_abnormal_dermal_layer0.82506667
114MP0004957_abnormal_blastocyst_morpholog0.82169081
115MP0003221_abnormal_cardiomyocyte_apopto0.81786550
116MP0003943_abnormal_hepatobiliary_system0.81775784
117MP0004858_abnormal_nervous_system0.81750708
118MP0005365_abnormal_bile_salt0.80902299
119* MP0002086_abnormal_extraembryonic_tissu0.80824722
120MP0003795_abnormal_bone_structure0.80813361
121MP0002234_abnormal_pharynx_morphology0.80615102
122MP0001881_abnormal_mammary_gland0.80098191
123MP0005367_renal/urinary_system_phenotyp0.80054737
124MP0000516_abnormal_urinary_system0.80054737
125MP0000534_abnormal_ureter_morphology0.79554473
126MP0001661_extended_life_span0.77285256
127MP0005187_abnormal_penis_morphology0.75765753
128MP0003755_abnormal_palate_morphology0.75600587
129MP0002092_abnormal_eye_morphology0.75259410
130MP0002088_abnormal_embryonic_growth/wei0.75238509
131MP0003984_embryonic_growth_retardation0.74175087
132MP0001666_abnormal_nutrient_absorption0.74139948
133MP0008058_abnormal_DNA_repair0.73518520
134* MP0001730_embryonic_growth_arrest0.72417826
135MP0002166_altered_tumor_susceptibility0.72086730
136MP0004782_abnormal_surfactant_physiolog0.71128747
137MP0002078_abnormal_glucose_homeostasis0.71016527
138MP0002113_abnormal_skeleton_development0.71005082
139MP0009643_abnormal_urine_homeostasis0.70556330
140MP0003172_abnormal_lysosome_physiology0.70094477
141* MP0001697_abnormal_embryo_size0.68030190
142MP0001915_intracranial_hemorrhage0.66727571
143MP0000432_abnormal_head_morphology0.66510252
144MP0002108_abnormal_muscle_morphology0.66432971
145* MP0002925_abnormal_cardiovascular_devel0.65845495
146MP0003119_abnormal_digestive_system0.65591243

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.00878600
2Protrusio acetabuli (HP:0003179)3.95629937
3Hyperinsulinemic hypoglycemia (HP:0000825)3.70740513
4Hypoglycemic seizures (HP:0002173)3.56939327
5Cervical subluxation (HP:0003308)3.40752538
6Hypoglycemic coma (HP:0001325)3.33281511
7Cerebral aneurysm (HP:0004944)3.16044065
8Abnormality of the intrinsic pathway (HP:0010989)3.04453786
9Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.96586280
10Aortic aneurysm (HP:0004942)2.87766571
11Symptomatic seizures (HP:0011145)2.86897243
12Hyperglycemia (HP:0003074)2.84590050
13Abnormality of endocrine pancreas physiology (HP:0012093)2.80826350
14Abnormality of the pancreatic islet cells (HP:0006476)2.80826350
15Aortic dissection (HP:0002647)2.79819879
16Macroorchidism (HP:0000053)2.76500355
17Shallow orbits (HP:0000586)2.75201243
18Back pain (HP:0003418)2.74816701
19Flat acetabular roof (HP:0003180)2.68633352
20Small epiphyses (HP:0010585)2.65094778
21Subacute progressive viral hepatitis (HP:0006572)2.63105553
22Aneurysm (HP:0002617)2.61503923
23Abnormality of the common coagulation pathway (HP:0010990)2.58599862
24Ankle contracture (HP:0006466)2.57956320
25Atrophic scars (HP:0001075)2.57562905
26Mucopolysacchariduria (HP:0008155)2.55947040
27Urinary glycosaminoglycan excretion (HP:0003541)2.55947040
28Thin bony cortex (HP:0002753)2.50154042
29Pancreatic islet-cell hyperplasia (HP:0004510)2.49650504
30Increased nuchal translucency (HP:0010880)2.48072427
31Abnormality of dentin (HP:0010299)2.47967780
32Right ventricular cardiomyopathy (HP:0011663)2.46833278
33Bladder diverticulum (HP:0000015)2.42738423
34Volvulus (HP:0002580)2.40373882
35Wormian bones (HP:0002645)2.39594942
36Reduced antithrombin III activity (HP:0001976)2.38188775
37Abnormal tarsal ossification (HP:0008369)2.36723758
38Thoracolumbar scoliosis (HP:0002944)2.36557519
39Soft skin (HP:0000977)2.34888620
40Dilatation of the ascending aorta (HP:0005111)2.31893898
41Chromsome breakage (HP:0040012)2.31307486
42Deep venous thrombosis (HP:0002625)2.27383868
43Mitral valve prolapse (HP:0001634)2.26592002
44Spondylolisthesis (HP:0003302)2.26360324
45Vertebral compression fractures (HP:0002953)2.25016251
46Overlapping toe (HP:0001845)2.24518738
47Dysostosis multiplex (HP:0000943)2.24117087
48Abnormal pancreas size (HP:0012094)2.21954698
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20525251
50Blue sclerae (HP:0000592)2.19430410
51Hematochezia (HP:0002573)2.17855256
52Abnormality of carpal bone ossification (HP:0006257)2.17772606
53Pterygium (HP:0001059)2.13515232
54Abnormality of polysaccharide metabolism (HP:0011012)2.12561816
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12561816
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12561816
57Insidious onset (HP:0003587)2.12271253
58Termporal pattern (HP:0011008)2.12271253
59Peritonitis (HP:0002586)2.11660849
60Rectal prolapse (HP:0002035)2.07590048
61Exostoses (HP:0100777)2.06271954
62Renal duplication (HP:0000075)2.05349022
63Abnormal delivery (HP:0001787)2.04102367
64Bowel diverticulosis (HP:0005222)2.03635124
65Buphthalmos (HP:0000557)2.00406112
66Hypoplastic labia majora (HP:0000059)1.99823618
67Missing ribs (HP:0000921)1.98673654
68Deviation of the thumb (HP:0009603)1.94084018
69Breech presentation (HP:0001623)1.93632961
70Hand muscle atrophy (HP:0009130)1.93496080
71Selective tooth agenesis (HP:0001592)1.91629919
72Abnormal foot bone ossification (HP:0010675)1.91311306
73Osteolytic defects of the hand bones (HP:0009699)1.91048808
74Osteolytic defects of the phalanges of the hand (HP:0009771)1.91048808
75Cortical dysplasia (HP:0002539)1.90918878
76Congenital glaucoma (HP:0001087)1.90809359
77Tibial bowing (HP:0002982)1.90548785
78Short nail (HP:0001799)1.90120067
79Broad face (HP:0000283)1.89869149
80Abdominal distention (HP:0003270)1.89451714
81Deep philtrum (HP:0002002)1.88313222
82Long toe (HP:0010511)1.87919866
83Hyperacusis (HP:0010780)1.87220252
84Nonimmune hydrops fetalis (HP:0001790)1.86593917
85Vascular tortuosity (HP:0004948)1.85727140
86Syringomyelia (HP:0003396)1.85659541
87Spinal cord lesions (HP:0100561)1.85659541
88Ankyloglossia (HP:0010296)1.84530472
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84189050
90Short 4th metacarpal (HP:0010044)1.84189050
91Severe short stature (HP:0003510)1.84171609
92Milia (HP:0001056)1.83892621
93Lymphangioma (HP:0100764)1.83851886
94Arterial tortuosity (HP:0005116)1.82412962
95Advanced eruption of teeth (HP:0006288)1.82208253
96Natal tooth (HP:0000695)1.80774988
97Asymmetry of the thorax (HP:0001555)1.80274545
98Ketoacidosis (HP:0001993)1.80005765
99Coronal craniosynostosis (HP:0004440)1.78346651
100Abnormality of oral frenula (HP:0000190)1.78166715
101Abnormality of the labia majora (HP:0012881)1.77335751
102Biliary tract neoplasm (HP:0100574)1.77332464
103Onycholysis (HP:0001806)1.76796241
104Papilledema (HP:0001085)1.76794376
105Abnormal ossification of hand bones (HP:0005921)1.76248779
106Protuberant abdomen (HP:0001538)1.75820702
107Microglossia (HP:0000171)1.75673949
108Insulin-resistant diabetes mellitus (HP:0000831)1.75258597
109Disproportionate tall stature (HP:0001519)1.75200236
110Mitral stenosis (HP:0001718)1.74743885
111Rhizomelia (HP:0008905)1.74240628
112Broad thumb (HP:0011304)1.73622028
113Vertebral arch anomaly (HP:0008438)1.73219696
114Enlarged penis (HP:0000040)1.71682124
115Abnormality of the umbilical cord (HP:0010881)1.70759792
116Abnormal biliary tract morphology (HP:0012440)1.69862844
117Abnormality of the acetabulum (HP:0003170)1.68913333
118Femoral bowing (HP:0002980)1.68526269
119Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68175583
120Mesomelia (HP:0003027)1.67917012
121Abnormality of the fetal cardiovascular system (HP:0010948)1.67854614
122Abnormal umbilical cord blood vessels (HP:0011403)1.67854614
123Single umbilical artery (HP:0001195)1.67854614
124Elbow flexion contracture (HP:0002987)1.67656781
125Insomnia (HP:0100785)1.66371352
126Orthostatic hypotension (HP:0001278)1.66180130
127Embryonal renal neoplasm (HP:0011794)1.66036053
128Relative macrocephaly (HP:0004482)1.65881514
129Entropion (HP:0000621)1.65757213
130Skin nodule (HP:0200036)1.64873981
131Platyspondyly (HP:0000926)1.64655658
132Abnormality of the calcaneus (HP:0008364)1.64123304
133Distal upper limb amyotrophy (HP:0007149)1.63976827
134Upper limb amyotrophy (HP:0009129)1.63976827
135Abnormality of calcium-phosphate metabolism (HP:0100530)1.63418016
136Ulnar bowing (HP:0003031)1.63257201
137Proximal placement of thumb (HP:0009623)1.62481700
138Deviation of the hallux (HP:0010051)1.61713406
139Neonatal short-limb short stature (HP:0008921)1.61663554
140Limited elbow extension (HP:0001377)1.61238250
141Broad long bones (HP:0005622)1.61144251
142Hallux valgus (HP:0001822)1.60960976
143Nephroblastoma (Wilms tumor) (HP:0002667)1.60862239
144Type I transferrin isoform profile (HP:0003642)1.60293284
145Follicular hyperkeratosis (HP:0007502)1.60103584
146Abnormality of the distal phalanges of the toes (HP:0010182)1.59691781
147Broad palm (HP:0001169)1.59564058
148Fragile skin (HP:0001030)1.58847696
149Abnormality of glycolysis (HP:0004366)1.57307617
150Short middle phalanx of the 5th finger (HP:0004220)1.56864754
151Cupped ribs (HP:0000887)1.56555818
152Camptodactyly of toe (HP:0001836)1.56488523
153Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.56353550
154Prominent forehead (HP:0011220)1.56290358
155Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.56234336
156Vertebral hypoplasia (HP:0008417)1.56234336
157Bell-shaped thorax (HP:0001591)1.56181983
158Spastic diplegia (HP:0001264)1.55666594
159Scapular winging (HP:0003691)1.55476766
160Hyperextensible skin (HP:0000974)1.55319520
161Midface retrusion (HP:0011800)1.54483903
162Abnormal hand bone ossification (HP:0010660)1.53095381
163Flattened epiphyses (HP:0003071)1.51995467
164Abnormalities of placenta or umbilical cord (HP:0001194)1.51327907
165Papillary thyroid carcinoma (HP:0002895)1.51274464
166Delayed cranial suture closure (HP:0000270)1.49986897
167Protruding ear (HP:0000411)1.49906023
168Arnold-Chiari malformation (HP:0002308)1.48963464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.70815001
2FRK3.69608602
3LATS13.26161030
4PASK3.03630678
5SCYL22.90839129
6INSRR2.75526549
7PDGFRA2.53384550
8TAOK32.51682770
9LATS22.44909132
10EIF2AK12.33733343
11NEK12.28953068
12PKN22.27254347
13TRIB32.21028139
14PTK62.10340971
15CDK121.98214452
16SIK11.90029837
17ERBB41.88668683
18BUB11.86438216
19DDR21.81659650
20FLT31.81293146
21PBK1.77454076
22WEE11.77016577
23TTN1.74250972
24ICK1.71604900
25MAPK151.68188861
26MET1.67083146
27SMG11.65540292
28STK31.57940078
29SRPK11.57174951
30PTK21.48322032
31MAP3K21.48091719
32CDC71.44303722
33EPHA31.43815273
34TESK11.35450915
35RIPK11.34044277
36EPHA21.31213596
37PAK21.30888785
38BRSK21.27730793
39MTOR1.23623075
40FER1.22066878
41NUAK11.19816097
42CAMK1D1.19233005
43NEK91.16692551
44CAMK1G1.14044738
45PLK41.12337485
46PRKD31.09949466
47MAP3K101.04704208
48ERBB31.04013836
49PDGFRB1.03755629
50YES11.03116768
51HIPK21.02230384
52CDK71.00948727
53MKNK20.99810478
54MST40.98308582
55EIF2AK30.97058629
56CDK60.96906701
57STK100.95595277
58PAK40.94458792
59NEK20.94254526
60WNK40.93238637
61PAK30.92518185
62FGFR10.92110182
63CDC42BPA0.90829084
64BRD40.90794243
65RPS6KA40.89655766
66LRRK20.89630940
67DYRK1B0.89232479
68BCR0.88702604
69PLK30.88386524
70IRAK30.87848786
71CLK10.86218702
72FGFR20.85085277
73BRSK10.84423548
74AKT30.84222970
75TGFBR10.82856964
76TAF10.79118490
77FGFR30.77946559
78NTRK10.77032414
79CHEK20.76786103
80PIK3CG0.76675235
81EEF2K0.76303900
82PLK10.74993992
83BMX0.72206488
84WNK30.71858555
85NME20.67365597
86BRAF0.65660652
87MELK0.65426649
88JAK10.64348646
89EPHB10.62785787
90TRPM70.62715456
91ROCK20.61938421
92PDK20.60863067
93ATM0.60573128
94EIF2AK20.60510981
95FGFR40.60334552
96WNK10.59938870
97MAP3K90.59738824
98DMPK0.57830959
99MAP3K80.57754341
100MAP3K140.57134726
101RET0.56879809
102ALK0.56724726
103MAPK100.56353076
104CDK10.53721338
105CHEK10.52903308
106CDK40.52810456
107TSSK60.52209413
108PRKDC0.51887325
109MKNK10.51289194
110TTK0.49761733
111ARAF0.49221446
112AURKB0.48982719
113STK240.48533722
114INSR0.47952311
115MAP3K120.47267732
116ATR0.47190827
117IGF1R0.46520468
118GSK3A0.46509762
119PLK20.44645944
120LMTK20.44422049
121MST1R0.43029918
122EGFR0.41805373
123CDK20.40197963
124MAPK140.38370505
125ITK0.37190767
126LIMK10.37172215
127PNCK0.36857703
128TGFBR20.35519517
129JAK30.34754677
130RPS6KB20.33409038
131MARK30.33110701
132CSK0.32571053
133MAPK10.31341409
134CSNK1E0.30315968
135PRKCH0.29589103
136CHUK0.29553232
137STK38L0.29419900

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.53257914
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.32373690
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.98830773
4Sulfur metabolism_Homo sapiens_hsa009202.76820090
5N-Glycan biosynthesis_Homo sapiens_hsa005102.63830513
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34845649
7Selenocompound metabolism_Homo sapiens_hsa004502.33853236
8Antigen processing and presentation_Homo sapiens_hsa046122.14682960
9ECM-receptor interaction_Homo sapiens_hsa045122.02331684
10DNA replication_Homo sapiens_hsa030301.93018743
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89857551
12Steroid biosynthesis_Homo sapiens_hsa001001.72397482
13Biosynthesis of amino acids_Homo sapiens_hsa012301.65355137
14Focal adhesion_Homo sapiens_hsa045101.60446926
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.52608321
16Non-homologous end-joining_Homo sapiens_hsa034501.52329258
17Adherens junction_Homo sapiens_hsa045201.51996812
18Mismatch repair_Homo sapiens_hsa034301.50719107
19Spliceosome_Homo sapiens_hsa030401.49437270
20* Thyroid hormone synthesis_Homo sapiens_hsa049181.45947788
21Vibrio cholerae infection_Homo sapiens_hsa051101.44265791
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42694867
23Nucleotide excision repair_Homo sapiens_hsa034201.38120244
24Pyruvate metabolism_Homo sapiens_hsa006201.37294258
25Fructose and mannose metabolism_Homo sapiens_hsa000511.34862501
26Lysosome_Homo sapiens_hsa041421.32869450
27Lysine degradation_Homo sapiens_hsa003101.31583501
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30907722
29Protein digestion and absorption_Homo sapiens_hsa049741.30299497
30One carbon pool by folate_Homo sapiens_hsa006701.28578045
31Proteoglycans in cancer_Homo sapiens_hsa052051.28452772
32Carbon metabolism_Homo sapiens_hsa012001.24517949
33Small cell lung cancer_Homo sapiens_hsa052221.22940391
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12699154
35Amoebiasis_Homo sapiens_hsa051461.10915664
36Bladder cancer_Homo sapiens_hsa052191.10237716
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08992624
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04357149
39Complement and coagulation cascades_Homo sapiens_hsa046101.03393935
40MicroRNAs in cancer_Homo sapiens_hsa052061.03068342
41Renin-angiotensin system_Homo sapiens_hsa046141.02947956
42TGF-beta signaling pathway_Homo sapiens_hsa043501.01930222
43Prion diseases_Homo sapiens_hsa050201.00696619
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99378187
45* Prostate cancer_Homo sapiens_hsa052150.98531350
46Tryptophan metabolism_Homo sapiens_hsa003800.98136610
47Type II diabetes mellitus_Homo sapiens_hsa049300.97545230
48Pentose phosphate pathway_Homo sapiens_hsa000300.95935800
49Insulin resistance_Homo sapiens_hsa049310.95393312
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92640933
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92608447
52Nitrogen metabolism_Homo sapiens_hsa009100.92185356
53Proteasome_Homo sapiens_hsa030500.90060665
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88510456
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.87925067
56Vitamin digestion and absorption_Homo sapiens_hsa049770.86531245
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85719331
58Fatty acid biosynthesis_Homo sapiens_hsa000610.83559097
59Base excision repair_Homo sapiens_hsa034100.83182427
60Viral carcinogenesis_Homo sapiens_hsa052030.83162824
61Legionellosis_Homo sapiens_hsa051340.82260149
62Chronic myeloid leukemia_Homo sapiens_hsa052200.81638987
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81609012
64Insulin secretion_Homo sapiens_hsa049110.81399979
65Hippo signaling pathway_Homo sapiens_hsa043900.81247662
66Phagosome_Homo sapiens_hsa041450.79954453
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.78980238
68Starch and sucrose metabolism_Homo sapiens_hsa005000.77263967
69Glucagon signaling pathway_Homo sapiens_hsa049220.73739573
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71441357
71Type I diabetes mellitus_Homo sapiens_hsa049400.71360483
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.71216497
73mTOR signaling pathway_Homo sapiens_hsa041500.68855309
74Fatty acid metabolism_Homo sapiens_hsa012120.67579712
75* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67231737
76Pancreatic cancer_Homo sapiens_hsa052120.66463123
77Arginine and proline metabolism_Homo sapiens_hsa003300.65829748
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65338827
79Arginine biosynthesis_Homo sapiens_hsa002200.64646589
80Sphingolipid metabolism_Homo sapiens_hsa006000.64393612
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.63400605
82Tight junction_Homo sapiens_hsa045300.63380847
83Thyroid cancer_Homo sapiens_hsa052160.63219921
84Oocyte meiosis_Homo sapiens_hsa041140.60786523
85Other glycan degradation_Homo sapiens_hsa005110.57795780
86Histidine metabolism_Homo sapiens_hsa003400.56275523
87Fat digestion and absorption_Homo sapiens_hsa049750.55555857
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55262431
89Propanoate metabolism_Homo sapiens_hsa006400.54931077
90HIF-1 signaling pathway_Homo sapiens_hsa040660.53358365
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53227861
92Tyrosine metabolism_Homo sapiens_hsa003500.52525019
93Cell cycle_Homo sapiens_hsa041100.52238445
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51956330
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51184893
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51030061
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50841580
98Colorectal cancer_Homo sapiens_hsa052100.50785960
99RNA transport_Homo sapiens_hsa030130.50233430
100Hedgehog signaling pathway_Homo sapiens_hsa043400.50168480
101Toxoplasmosis_Homo sapiens_hsa051450.49726896
102Fanconi anemia pathway_Homo sapiens_hsa034600.48784300
103Vitamin B6 metabolism_Homo sapiens_hsa007500.48772334
104Glutathione metabolism_Homo sapiens_hsa004800.47905885
105Renal cell carcinoma_Homo sapiens_hsa052110.46121462
106HTLV-I infection_Homo sapiens_hsa051660.46058802
107Endometrial cancer_Homo sapiens_hsa052130.45685253
108Melanoma_Homo sapiens_hsa052180.45400558
109Basal cell carcinoma_Homo sapiens_hsa052170.44326548
110Systemic lupus erythematosus_Homo sapiens_hsa053220.43944238
111Non-small cell lung cancer_Homo sapiens_hsa052230.43799980
112RNA degradation_Homo sapiens_hsa030180.43091269
113Shigellosis_Homo sapiens_hsa051310.42925713
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42568865
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41136795
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40541120
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40050278
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39434910
119Galactose metabolism_Homo sapiens_hsa000520.38152224
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38101137
121p53 signaling pathway_Homo sapiens_hsa041150.37980737
122* Estrogen signaling pathway_Homo sapiens_hsa049150.37908901
123AMPK signaling pathway_Homo sapiens_hsa041520.37757685
124Fatty acid degradation_Homo sapiens_hsa000710.36141206
125ABC transporters_Homo sapiens_hsa020100.35275949
126Phenylalanine metabolism_Homo sapiens_hsa003600.35120515
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.34935132
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34808196
129* Pathways in cancer_Homo sapiens_hsa052000.34688915
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34280589
131Glioma_Homo sapiens_hsa052140.32985989
132Cocaine addiction_Homo sapiens_hsa050300.31014907
133Pancreatic secretion_Homo sapiens_hsa049720.30545262
134Prolactin signaling pathway_Homo sapiens_hsa049170.28970752
135Wnt signaling pathway_Homo sapiens_hsa043100.28864465
136Staphylococcus aureus infection_Homo sapiens_hsa051500.28783678
137mRNA surveillance pathway_Homo sapiens_hsa030150.28731003
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27825408
139Dorso-ventral axis formation_Homo sapiens_hsa043200.26314705
140Platelet activation_Homo sapiens_hsa046110.25585784

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