ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.91244856
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.64209042
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.04291790
4	ATP synthesis coupled proton transport (GO:0015986)	4.91297463
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.91297463
6	proteasome assembly (GO:0043248)	4.91226555
7	protein neddylation (GO:0045116)	4.48443688
8	cytidine metabolic process (GO:0046087)	4.39668911
9	cytidine catabolic process (GO:0006216)	4.39668911
10	cytidine deamination (GO:0009972)	4.39668911
11	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.35688569
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.35688569
13	signal peptide processing (GO:0006465)	4.34058618
14	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.23832072
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.20147556
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.20147556
17	NADH dehydrogenase complex assembly (GO:0010257)	4.20147556
18	protein complex biogenesis (GO:0070271)	4.18570928
19	chaperone-mediated protein transport (GO:0072321)	4.03920529
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.99678374
21	respiratory chain complex IV assembly (GO:0008535)	3.98099912
22	regulation of isotype switching to IgG isotypes (GO:0048302)	3.91696663
23	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.90417676
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.85370380
25	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.83431329
26	regulation of regulatory T cell differentiation (GO:0045589)	3.83075531
27	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.81509171
28	rRNA modification (GO:0000154)	3.79003633
29	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.78835982
30	respiratory electron transport chain (GO:0022904)	3.67518985
31	electron transport chain (GO:0022900)	3.66633064
32	rRNA methylation (GO:0031167)	3.61015470
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.54441978
34	cytochrome complex assembly (GO:0017004)	3.43689375
35	ribosomal small subunit assembly (GO:0000028)	3.38941453
36	platelet dense granule organization (GO:0060155)	3.27131736
37	preassembly of GPI anchor in ER membrane (GO:0016254)	3.26981927
38	GTP biosynthetic process (GO:0006183)	3.23420757
39	behavioral response to nicotine (GO:0035095)	3.22347667
40	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.22055976
41	termination of RNA polymerase III transcription (GO:0006386)	3.22055976
42	hydrogen ion transmembrane transport (GO:1902600)	3.18312447
43	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.17108905
44	positive regulation of defense response to virus by host (GO:0002230)	3.13814274
45	water-soluble vitamin biosynthetic process (GO:0042364)	3.10718583
46	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.07130137
47	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.05509059
48	regulation of mitochondrial translation (GO:0070129)	3.04423956
49	regulation of cellular amino acid metabolic process (GO:0006521)	3.02317530
50	ATP biosynthetic process (GO:0006754)	2.99852733
51	kynurenine metabolic process (GO:0070189)	2.99768194
52	proton transport (GO:0015992)	2.99451798
53	hydrogen transport (GO:0006818)	2.95523832
54	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.94744886
55	negative regulation of ligase activity (GO:0051352)	2.94744886
56	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.93108326
57	sequestering of actin monomers (GO:0042989)	2.90635311
58	pseudouridine synthesis (GO:0001522)	2.82067880
59	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.80761346
60	mannosylation (GO:0097502)	2.80735993
61	negative regulation by host of viral transcription (GO:0043922)	2.80193848
62	retinal cone cell development (GO:0046549)	2.79109007
63	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.78970063
64	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.77305304
65	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.77305304
66	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.77305304
67	indolalkylamine catabolic process (GO:0046218)	2.75521849
68	tryptophan catabolic process (GO:0006569)	2.75521849
69	indole-containing compound catabolic process (GO:0042436)	2.75521849
70	maturation of SSU-rRNA (GO:0030490)	2.72168251
71	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.71793370
72	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.71793370
73	protein peptidyl-prolyl isomerization (GO:0000413)	2.64512111
74	tRNA processing (GO:0008033)	2.62919207
75	cotranslational protein targeting to membrane (GO:0006613)	2.62020489
76	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.61797422
77	regulation of mesoderm development (GO:2000380)	2.61630226
78	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.60735894
79	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.60735894
80	regulation of thymocyte apoptotic process (GO:0070243)	2.59899990
81	regulation of chronic inflammatory response (GO:0002676)	2.59462573
82	GPI anchor metabolic process (GO:0006505)	2.59024527
83	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.58800672
84	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.58048134
85	cellular component biogenesis (GO:0044085)	2.57557606
86	positive regulation of prostaglandin secretion (GO:0032308)	2.57280959
87	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.56467413
88	protein targeting to ER (GO:0045047)	2.56123527
89	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.52741922
90	DNA damage response, detection of DNA damage (GO:0042769)	2.51519887
91	N-acetylglucosamine metabolic process (GO:0006044)	2.51023014
92	UTP biosynthetic process (GO:0006228)	2.51014658
93	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.50938380
94	isotype switching (GO:0045190)	2.50938380
95	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.50938380
96	protein-cofactor linkage (GO:0018065)	2.50462687
97	thalamus development (GO:0021794)	2.50193980
98	translation (GO:0006412)	2.49672946
99	regulation of T cell receptor signaling pathway (GO:0050856)	2.49014192
100	ribosomal large subunit biogenesis (GO:0042273)	2.48496218

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.50655709
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.65419717
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.21554919
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.42662101
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.02030795
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.99495025
7	VDR_22108803_ChIP-Seq_LS180_Human	2.87172394
8	ELK1_19687146_ChIP-ChIP_HELA_Human	2.82672329
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.80011902
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.55532499
11	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.48329983
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.45047677
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.40827033
14	* EWS_26573619_Chip-Seq_HEK293_Human	2.30295764
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.21393375
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.19051485
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.17514868
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.16373604
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.12730922
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.93218460
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.90631630
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.90408880
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.89869034
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.88951611
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.79198442
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.78517871
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.75817350
28	FUS_26573619_Chip-Seq_HEK293_Human	1.62173774
29	P300_19829295_ChIP-Seq_ESCs_Human	1.60894785
30	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.59633276
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57312423
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55247355
33	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.54817678
34	SOX2_19829295_ChIP-Seq_ESCs_Human	1.47489288
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.47489288
36	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.45162441
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45124081
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.44001267
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.43147629
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.42698935
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42264082
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.41507478
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.39706618
44	AR_20517297_ChIP-Seq_VCAP_Human	1.37482732
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36928182
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.36396321
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.28785993
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28401254
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28231962
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.26016758
51	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.23488211
52	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.23481681
53	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.23381508
54	E2F7_22180533_ChIP-Seq_HELA_Human	1.22623083
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.21385506
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.21201892
57	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.20021183
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20014494
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.20014494
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19453276
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19453276
62	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.14844364
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.12988692
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.11136625
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08115066
66	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07444328
67	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.07185682
68	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.06579714
69	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.06386551
70	GATA3_26560356_Chip-Seq_TH2_Human	1.05612207
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05049015
72	TTF2_22483619_ChIP-Seq_HELA_Human	1.04972586
73	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.04787007
74	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.03954194
75	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.02434834
76	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.97121607
77	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.97004551
78	* TCF4_22108803_ChIP-Seq_LS180_Human	0.96566666
79	BCAT_22108803_ChIP-Seq_LS180_Human	0.96397761
80	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.96078957
81	DCP1A_22483619_ChIP-Seq_HELA_Human	0.95670382
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.95494732
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95254716
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94245469
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92421548
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.91883529
87	NCOR_22424771_ChIP-Seq_293T_Human	0.91464246
88	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.91325349
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.91055959
90	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.90329116
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.89809195
92	GABP_19822575_ChIP-Seq_HepG2_Human	0.89200531
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87043024
94	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.87017032
95	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.85585885
96	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.85209913
97	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.84429106
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.84244562
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.83881072
100	* PRDM14_20953172_ChIP-Seq_ESCs_Human	0.82930838

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006072_abnormal_retinal_apoptosis	4.10905783
2	MP0005671_abnormal_response_to	3.86066971
3	MP0006054_spinal_hemorrhage	3.40138336
4	MP0009379_abnormal_foot_pigmentation	2.77334928
5	MP0009697_abnormal_copulation	2.68870777
6	MP0000569_abnormal_digit_pigmentation	2.65792801
7	MP0001835_abnormal_antigen_presentation	2.59755333
8	MP0003786_premature_aging	2.48889905
9	MP0002102_abnormal_ear_morphology	2.25016632
10	MP0004147_increased_porphyrin_level	2.12206531
11	MP0005253_abnormal_eye_physiology	2.11248523
12	MP0005551_abnormal_eye_electrophysiolog	2.01851690
13	MP0001293_anophthalmia	1.92864288
14	MP0006292_abnormal_olfactory_placode	1.89720450
15	MP0002938_white_spotting	1.86920493
16	MP0001873_stomach_inflammation	1.86637949
17	MP0005408_hypopigmentation	1.85561146
18	MP0005084_abnormal_gallbladder_morpholo	1.73767690
19	MP0003252_abnormal_bile_duct	1.71687547
20	MP0002837_dystrophic_cardiac_calcinosis	1.70970496
21	MP0005174_abnormal_tail_pigmentation	1.68550624
22	MP0003119_abnormal_digestive_system	1.66299017
23	MP0005645_abnormal_hypothalamus_physiol	1.66137210
24	MP0003718_maternal_effect	1.65988584
25	MP0003195_calcinosis	1.58654330
26	MP0001529_abnormal_vocalization	1.51477014
27	MP0000372_irregular_coat_pigmentation	1.49436294
28	MP0002396_abnormal_hematopoietic_system	1.42181132
29	MP0008872_abnormal_physiological_respon	1.40582017
30	MP0002006_tumorigenesis	1.39158039
31	MP0001485_abnormal_pinna_reflex	1.36161387
32	MP0005646_abnormal_pituitary_gland	1.32942175
33	MP0008877_abnormal_DNA_methylation	1.31676371
34	MP0002933_joint_inflammation	1.31547198
35	MP0002148_abnormal_hypersensitivity_rea	1.30260014
36	MP0002277_abnormal_respiratory_mucosa	1.27205092
37	MP0006036_abnormal_mitochondrial_physio	1.26108834
38	MP0008789_abnormal_olfactory_epithelium	1.25938378
39	MP0004742_abnormal_vestibular_system	1.23866897
40	MP0002234_abnormal_pharynx_morphology	1.18537356
41	MP0003186_abnormal_redox_activity	1.17305682
42	MP0008995_early_reproductive_senescence	1.15728990
43	MP0008875_abnormal_xenobiotic_pharmacok	1.15726984
44	MP0003011_delayed_dark_adaptation	1.15556874
45	MP0003283_abnormal_digestive_organ	1.13589833
46	MP0003890_abnormal_embryonic-extraembry	1.12148163
47	MP0001346_abnormal_lacrimal_gland	1.11261117
48	MP0001764_abnormal_homeostasis	1.10901066
49	MP0000427_abnormal_hair_cycle	1.08806525
50	MP0000631_abnormal_neuroendocrine_gland	1.08077559
51	MP0005391_vision/eye_phenotype	1.07996963
52	MP0004885_abnormal_endolymph	1.07640121
53	MP0004215_abnormal_myocardial_fiber	1.06565562
54	MP0003693_abnormal_embryo_hatching	1.06110804
55	MP0002160_abnormal_reproductive_system	1.05848047
56	MP0005389_reproductive_system_phenotype	1.01398154
57	MP0004142_abnormal_muscle_tone	0.98603203
58	MP0002254_reproductive_system_inflammat	0.95936093
59	MP0003137_abnormal_impulse_conducting	0.94252402
60	MP0005332_abnormal_amino_acid	0.93819991
61	MP0002876_abnormal_thyroid_physiology	0.92478600
62	MP0001800_abnormal_humoral_immune	0.92425111
63	MP0002233_abnormal_nose_morphology	0.90823866
64	MP0001905_abnormal_dopamine_level	0.89928506
65	MP0001756_abnormal_urination	0.86830878
66	MP0010094_abnormal_chromosome_stability	0.86708242
67	MP0010030_abnormal_orbit_morphology	0.86295070
68	MP0002095_abnormal_skin_pigmentation	0.86274650
69	MP0003724_increased_susceptibility_to	0.85822191
70	MP0005195_abnormal_posterior_eye	0.85332434
71	MP0004133_heterotaxia	0.83972067
72	MP0003937_abnormal_limbs/digits/tail_de	0.82089181
73	MP0002163_abnormal_gland_morphology	0.82050530
74	MP0002751_abnormal_autonomic_nervous	0.80618505
75	MP0002928_abnormal_bile_duct	0.80363703
76	MP0008058_abnormal_DNA_repair	0.80293360
77	MP0004782_abnormal_surfactant_physiolog	0.77664428
78	MP0000566_synostosis	0.77162674
79	MP0000685_abnormal_immune_system	0.77042018
80	MP0001881_abnormal_mammary_gland	0.76321905
81	MP0005360_urolithiasis	0.75436426
82	MP0002166_altered_tumor_susceptibility	0.73875046
83	MP0009764_decreased_sensitivity_to	0.70900495
84	MP0001853_heart_inflammation	0.69240420
85	MP0002210_abnormal_sex_determination	0.68041210
86	MP0010307_abnormal_tumor_latency	0.67777881
87	MP0005085_abnormal_gallbladder_physiolo	0.67220738
88	MP0002136_abnormal_kidney_physiology	0.67079576
89	MP0001845_abnormal_inflammatory_respons	0.66860286
90	MP0001819_abnormal_immune_cell	0.66214195
91	MP0002272_abnormal_nervous_system	0.66177259
92	MP0002452_abnormal_antigen_presenting	0.65583402
93	MP0001119_abnormal_female_reproductive	0.65492126
94	MP0006035_abnormal_mitochondrial_morpho	0.65474096
95	MP0009785_altered_susceptibility_to	0.65318848
96	MP0005000_abnormal_immune_tolerance	0.64438654
97	MP0002405_respiratory_system_inflammati	0.64374231
98	MP0000026_abnormal_inner_ear	0.63692907
99	MP0002723_abnormal_immune_serum	0.63579077
100	MP0001790_abnormal_immune_system	0.63231609

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	4.52087397
2	Mitochondrial inheritance (HP:0001427)	4.01452943
3	Hepatocellular necrosis (HP:0001404)	3.74308779
4	IgG deficiency (HP:0004315)	3.70030113
5	Increased CSF lactate (HP:0002490)	3.61567401
6	Acute necrotizing encephalopathy (HP:0006965)	3.52298372
7	Increased hepatocellular lipid droplets (HP:0006565)	3.48099305
8	Hepatic necrosis (HP:0002605)	3.42816206
9	Posterior subcapsular cataract (HP:0007787)	3.36444830
10	Lipid accumulation in hepatocytes (HP:0006561)	3.23877423
11	Congenital stationary night blindness (HP:0007642)	3.19453763
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.08007314
13	3-Methylglutaconic aciduria (HP:0003535)	3.07812480
14	Acute encephalopathy (HP:0006846)	3.06375066
15	Abnormal number of erythroid precursors (HP:0012131)	3.04773848
16	Pancreatic cysts (HP:0001737)	3.02916393
17	Chronic diarrhea (HP:0002028)	2.98583893
18	Molar tooth sign on MRI (HP:0002419)	2.97753599
19	Abnormality of midbrain morphology (HP:0002418)	2.97753599
20	Nephronophthisis (HP:0000090)	2.89171315
21	Abnormality of B cell number (HP:0010975)	2.89141313
22	Abnormality of T cell physiology (HP:0011840)	2.87440335
23	Hypoproteinemia (HP:0003075)	2.85027292
24	Stomatitis (HP:0010280)	2.84100977
25	Renal Fanconi syndrome (HP:0001994)	2.83067270
26	Type I transferrin isoform profile (HP:0003642)	2.78634769
27	Pancreatic fibrosis (HP:0100732)	2.76765680
28	Progressive macrocephaly (HP:0004481)	2.76380537
29	Constricted visual fields (HP:0001133)	2.75548709
30	Abnormality of cells of the erythroid lineage (HP:0012130)	2.71630684
31	Hypoplasia of the pons (HP:0012110)	2.68808225
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.68392760
33	Abnormality of the pons (HP:0007361)	2.67471545
34	IgM deficiency (HP:0002850)	2.65387795
35	Methylmalonic acidemia (HP:0002912)	2.62458734
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.52178725
37	Increased serum lactate (HP:0002151)	2.48881824
38	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.46685714
39	Exertional dyspnea (HP:0002875)	2.46608273
40	Abolished electroretinogram (ERG) (HP:0000550)	2.46580615
41	Abnormal protein glycosylation (HP:0012346)	2.45291686
42	Abnormal glycosylation (HP:0012345)	2.45291686
43	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.45291686
44	Abnormal protein N-linked glycosylation (HP:0012347)	2.45291686
45	B lymphocytopenia (HP:0010976)	2.44982087
46	True hermaphroditism (HP:0010459)	2.44211489
47	Abnormality of T cells (HP:0002843)	2.43573926
48	Increased IgM level (HP:0003496)	2.41562588
49	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.41063189
50	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.41063189
51	Abnormal biliary tract physiology (HP:0012439)	2.40625456
52	Bile duct proliferation (HP:0001408)	2.40625456
53	Cerebral edema (HP:0002181)	2.39486988
54	Abnormality of the renal medulla (HP:0100957)	2.39413616
55	Severe combined immunodeficiency (HP:0004430)	2.35496743
56	Methylmalonic aciduria (HP:0012120)	2.33530394
57	Abnormality of the renal cortex (HP:0011035)	2.28895969
58	IgA deficiency (HP:0002720)	2.28237015
59	Increased intramyocellular lipid droplets (HP:0012240)	2.27005863
60	Lactic acidosis (HP:0003128)	2.26865851
61	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.24649820
62	Abnormality of alanine metabolism (HP:0010916)	2.24649820
63	Hyperalaninemia (HP:0003348)	2.24649820
64	Hyperglycinemia (HP:0002154)	2.14758646
65	Abnormality of the prostate (HP:0008775)	2.13673451
66	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.12485538
67	Aplasia/hypoplasia of the uterus (HP:0008684)	2.12129776
68	Optic disc pallor (HP:0000543)	2.06944666
69	Pendular nystagmus (HP:0012043)	2.06699989
70	Colon cancer (HP:0003003)	2.05534694
71	Hemoptysis (HP:0002105)	2.05051846
72	Renal cortical cysts (HP:0000803)	2.02721013
73	Humeroradial synostosis (HP:0003041)	1.99788281
74	Synostosis involving the elbow (HP:0003938)	1.99788281
75	Hypoplasia of the uterus (HP:0000013)	1.99093897
76	Aplastic anemia (HP:0001915)	1.96054946
77	Glycosuria (HP:0003076)	1.95700751
78	Abnormality of urine glucose concentration (HP:0011016)	1.95700751
79	Hypoalbuminemia (HP:0003073)	1.95502372
80	Abnormal albumin level (HP:0012116)	1.95502372
81	Cerebral palsy (HP:0100021)	1.93139689
82	Elevated erythrocyte sedimentation rate (HP:0003565)	1.92977455
83	Abnormality of renal resorption (HP:0011038)	1.91250953
84	Lethargy (HP:0001254)	1.90749692
85	Respiratory failure (HP:0002878)	1.90452385
86	Abnormality of T cell number (HP:0011839)	1.89227174
87	Abnormality of proline metabolism (HP:0010907)	1.88838117
88	Hydroxyprolinuria (HP:0003080)	1.88838117
89	Dyschromatopsia (HP:0007641)	1.88001472
90	Short hallux (HP:0010109)	1.87460679
91	Abnormal spermatogenesis (HP:0008669)	1.85959074
92	Tubular atrophy (HP:0000092)	1.85944749
93	Chronic hepatic failure (HP:0100626)	1.83880004
94	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.83098075
95	Absent/shortened dynein arms (HP:0200106)	1.83098075
96	Abnormality of serum amino acid levels (HP:0003112)	1.78773937
97	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.77981701
98	Cystic liver disease (HP:0006706)	1.77780126
99	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.77756628
100	Type 2 muscle fiber atrophy (HP:0003554)	1.75924774

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.21075759
2	TXK	4.17462032
3	NUAK1	2.90393658
4	TLK1	2.51377729
5	ACVR1B	2.51113741
6	MST4	2.48809007
7	WNK3	2.43516787
8	TNIK	2.42267360
9	ADRBK2	2.36555814
10	TRIM28	2.34695475
11	TAF1	2.33919692
12	BMPR1B	2.31641030
13	VRK1	2.21199092
14	TAOK3	2.08003086
15	GRK1	2.05053470
16	ZAK	2.03405613
17	NME1	1.92687574
18	EIF2AK3	1.80926985
19	BCKDK	1.77104540
20	STK16	1.73769243
21	MAP4K2	1.64256283
22	NEK1	1.57253134
23	TIE1	1.56915853
24	SRPK1	1.54075512
25	MAP3K12	1.52416381
26	INSRR	1.43377986
27	STK39	1.35682698
28	PLK3	1.34106066
29	BUB1	1.33033607
30	OXSR1	1.29051759
31	BRSK2	1.16587971
32	DAPK1	1.14999803
33	WNK4	1.12451454
34	MKNK1	1.10529146
35	EPHA3	1.09743613
36	TEC	1.09044164
37	FRK	1.06384402
38	MAPKAPK3	1.03209025
39	KDR	1.00660274
40	CDC7	0.98963282
41	ITK	0.95288590
42	NLK	0.93179764
43	PINK1	0.92715962
44	MKNK2	0.90588575
45	MAP3K13	0.86728039
46	CSNK1G1	0.86569592
47	PLK4	0.85839656
48	GRK5	0.84289122
49	IKBKB	0.82804455
50	PDK2	0.82764859
51	MYLK	0.81149667
52	BCR	0.79410458
53	TGFBR1	0.79038395
54	CSNK1G3	0.76061889
55	ADRBK1	0.75695092
56	CAMKK2	0.75125083
57	MAP3K9	0.73065593
58	DYRK2	0.69574869
59	LIMK1	0.69459327
60	CSK	0.66631771
61	TSSK6	0.65975326
62	FLT3	0.65941987
63	EIF2AK2	0.65284963
64	CSNK1A1L	0.64526424
65	CSNK1G2	0.61451851
66	NEK9	0.57767400
67	PRKCE	0.57081796
68	PRKCQ	0.53998876
69	MAP3K14	0.53460092
70	CDK19	0.51699758
71	PHKG1	0.51203027
72	PHKG2	0.51203027
73	PLK2	0.48653527
74	NEK2	0.48427158
75	MELK	0.48356554
76	PLK1	0.46722748
77	BTK	0.43047838
78	SCYL2	0.42167125
79	CSNK1A1	0.42132285
80	IRAK1	0.41425989
81	ERBB4	0.40892749
82	PRKCG	0.39963932
83	CSNK2A1	0.39946174
84	FES	0.39528922
85	EPHB2	0.39082366
86	ALK	0.38111210
87	PTK2B	0.37762363
88	CAMK2D	0.35803496
89	TTK	0.35441447
90	LYN	0.35387199
91	LATS1	0.34767873
92	CSNK2A2	0.34054374
93	MAP2K2	0.33684652
94	ATR	0.33237179
95	GRK7	0.32917384
96	AURKB	0.29989668
97	KIT	0.29470310
98	MOS	0.29304877
99	PBK	0.29284729
100	ILK	0.29136505

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.28598121
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.58521520
3	Protein export_Homo sapiens_hsa03060	3.24491033
4	Parkinsons disease_Homo sapiens_hsa05012	2.94489347
5	Ribosome_Homo sapiens_hsa03010	2.83042631
6	Asthma_Homo sapiens_hsa05310	2.51742201
7	RNA polymerase_Homo sapiens_hsa03020	2.47596355
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.37079345
9	Allograft rejection_Homo sapiens_hsa05330	2.24898114
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.22576597
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.13436601
12	Huntingtons disease_Homo sapiens_hsa05016	2.04467513
13	Phototransduction_Homo sapiens_hsa04744	1.96485865
14	Alzheimers disease_Homo sapiens_hsa05010	1.95554767
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.89318242
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.83811008
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.83367809
18	Homologous recombination_Homo sapiens_hsa03440	1.76739760
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.76729746
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.75107090
21	Basal transcription factors_Homo sapiens_hsa03022	1.72984276
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.69923401
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.62116000
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.61834967
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.60375938
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.59516417
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.52044280
28	RNA degradation_Homo sapiens_hsa03018	1.44138507
29	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.41527885
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.38306695
31	Propanoate metabolism_Homo sapiens_hsa00640	1.25632149
32	Sulfur metabolism_Homo sapiens_hsa00920	1.23085619
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.23022561
34	Antigen processing and presentation_Homo sapiens_hsa04612	1.22529638
35	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.22522962
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18498159
37	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.13782929
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.07370740
39	One carbon pool by folate_Homo sapiens_hsa00670	1.06742429
40	DNA replication_Homo sapiens_hsa03030	1.06113894
41	Purine metabolism_Homo sapiens_hsa00230	0.99482443
42	Spliceosome_Homo sapiens_hsa03040	0.97099283
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.95313212
44	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95105926
45	Mismatch repair_Homo sapiens_hsa03430	0.94534490
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.93726377
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92316545
48	Regulation of autophagy_Homo sapiens_hsa04140	0.91072594
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.89617556
50	Peroxisome_Homo sapiens_hsa04146	0.88808486
51	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.88153385
52	Folate biosynthesis_Homo sapiens_hsa00790	0.86510681
53	RNA transport_Homo sapiens_hsa03013	0.82760763
54	Steroid biosynthesis_Homo sapiens_hsa00100	0.81668987
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.79519620
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.78614694
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.76154007
58	Caffeine metabolism_Homo sapiens_hsa00232	0.74161328
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73180489
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70795182
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68278419
62	Glutathione metabolism_Homo sapiens_hsa00480	0.67879456
63	Butanoate metabolism_Homo sapiens_hsa00650	0.65814109
64	Metabolic pathways_Homo sapiens_hsa01100	0.65451565
65	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.65081857
66	Viral myocarditis_Homo sapiens_hsa05416	0.64618074
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.60443002
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59184074
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58410267
70	Fatty acid elongation_Homo sapiens_hsa00062	0.57749002
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.57482941
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57256246
73	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.57171927
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56704859
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53668746
76	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.52866265
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.52652941
78	Retinol metabolism_Homo sapiens_hsa00830	0.45973435
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45747090
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39053788
81	Olfactory transduction_Homo sapiens_hsa04740	0.38913305
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.37728595
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.35762603
84	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.34792503
85	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.34774276
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.32980136
87	Mineral absorption_Homo sapiens_hsa04978	0.32624566
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.32187233
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.31479886
90	Basal cell carcinoma_Homo sapiens_hsa05217	0.29439406
91	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.29303609
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.28266041
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.27651562
94	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.27170539
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.25261197
96	Fatty acid degradation_Homo sapiens_hsa00071	0.24699457
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.23837335
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.23576654
99	Nicotine addiction_Homo sapiens_hsa05033	0.23044663
100	Base excision repair_Homo sapiens_hsa03410	0.23015230

HSP90B3P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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