HSPA12A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.70948341
2synaptic vesicle maturation (GO:0016188)5.62359452
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.34931399
4locomotory exploration behavior (GO:0035641)5.12487132
5synaptic vesicle exocytosis (GO:0016079)5.11658454
6glutamate secretion (GO:0014047)4.96032925
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.94715392
8vocalization behavior (GO:0071625)4.92152153
9regulation of synaptic vesicle exocytosis (GO:2000300)4.82932813
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.64212075
11protein localization to synapse (GO:0035418)4.63103348
12neuronal action potential propagation (GO:0019227)4.61229610
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.53791125
14regulation of glutamate receptor signaling pathway (GO:1900449)4.38352708
15neuron cell-cell adhesion (GO:0007158)4.31256932
16regulation of synaptic vesicle transport (GO:1902803)4.30011016
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.24841278
18exploration behavior (GO:0035640)4.21961701
19layer formation in cerebral cortex (GO:0021819)4.10142278
20neurotransmitter secretion (GO:0007269)4.07631126
21cellular potassium ion homeostasis (GO:0030007)4.04070374
22regulation of neuronal synaptic plasticity (GO:0048168)4.02951906
23cerebellar granule cell differentiation (GO:0021707)3.99617220
24proline transport (GO:0015824)3.98622392
25glutamate receptor signaling pathway (GO:0007215)3.93405894
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.86887561
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.86725633
28L-amino acid import (GO:0043092)3.81706886
29synaptic transmission, glutamatergic (GO:0035249)3.81171797
30regulation of synapse structural plasticity (GO:0051823)3.74125481
31cellular sodium ion homeostasis (GO:0006883)3.69407884
32amino acid import (GO:0043090)3.67605839
33neuron-neuron synaptic transmission (GO:0007270)3.64119222
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.62435378
35sodium ion export (GO:0071436)3.62405370
36neuron recognition (GO:0008038)3.59161914
37negative regulation of dendrite morphogenesis (GO:0050774)3.57702758
38dendritic spine morphogenesis (GO:0060997)3.56408883
39positive regulation of dendritic spine development (GO:0060999)3.56098089
40activation of protein kinase A activity (GO:0034199)3.53713124
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50129405
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.49028928
43innervation (GO:0060384)3.48767722
44neurotransmitter-gated ion channel clustering (GO:0072578)3.46207957
45long-term memory (GO:0007616)3.45677388
46synaptic vesicle endocytosis (GO:0048488)3.45579083
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44019998
48positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.42857611
49cell communication by electrical coupling (GO:0010644)3.41402477
50cerebellar Purkinje cell differentiation (GO:0021702)3.38372160
51neurotransmitter transport (GO:0006836)3.37947776
52regulation of postsynaptic membrane potential (GO:0060078)3.34463885
53membrane depolarization during action potential (GO:0086010)3.34026054
54positive regulation of membrane potential (GO:0045838)3.33569857
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.32487707
56positive regulation of synapse maturation (GO:0090129)3.31947357
57axonal fasciculation (GO:0007413)3.31828355
58cell communication involved in cardiac conduction (GO:0086065)3.31679687
59regulation of synaptic plasticity (GO:0048167)3.30133301
60central nervous system myelination (GO:0022010)3.29045856
61axon ensheathment in central nervous system (GO:0032291)3.29045856
62neuromuscular synaptic transmission (GO:0007274)3.27882793
63neuromuscular process controlling balance (GO:0050885)3.24740716
64regulation of synapse maturation (GO:0090128)3.24671738
65vesicle transport along microtubule (GO:0047496)3.23642261
66gamma-aminobutyric acid transport (GO:0015812)3.22878027
67cell migration in hindbrain (GO:0021535)3.22691076
68regulation of voltage-gated calcium channel activity (GO:1901385)3.21579502
69regulation of vesicle fusion (GO:0031338)3.19466133
70regulation of dendritic spine morphogenesis (GO:0061001)3.17185325
71regulation of neurotransmitter secretion (GO:0046928)3.16686778
72transmission of nerve impulse (GO:0019226)3.16341336
73potassium ion import (GO:0010107)3.15239408
74long-term synaptic potentiation (GO:0060291)3.13092857
75neuromuscular process controlling posture (GO:0050884)3.13084728
76gamma-aminobutyric acid signaling pathway (GO:0007214)3.13080905
77dendrite morphogenesis (GO:0048813)3.12884691
78auditory behavior (GO:0031223)3.08271491
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07105157
80positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06119116
81regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05689318
82regulation of neurotransmitter levels (GO:0001505)3.05635841
83organelle transport along microtubule (GO:0072384)3.04904594
84membrane depolarization (GO:0051899)3.04612013
85regulation of synaptic transmission, glutamatergic (GO:0051966)3.04462894
86membrane hyperpolarization (GO:0060081)3.01962433
87regulation of dendritic spine development (GO:0060998)3.01796944
88axon cargo transport (GO:0008088)3.00445255
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97537632
90neurofilament cytoskeleton organization (GO:0060052)2.97490046
91negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93968241
92postsynaptic membrane organization (GO:0001941)2.93915290
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93835384
94behavioral defense response (GO:0002209)2.92904443
95behavioral fear response (GO:0001662)2.92904443
96glycine transport (GO:0015816)2.91970877
97cytoskeletal anchoring at plasma membrane (GO:0007016)2.91370080
98mating behavior (GO:0007617)2.90070718
99positive regulation of vesicle fusion (GO:0031340)2.89224713
100regulation of neurotransmitter transport (GO:0051588)2.88985556
101synapse assembly (GO:0007416)2.87569987
102positive regulation of potassium ion transmembrane transport (GO:1901381)2.86152724
103regulation of ARF protein signal transduction (GO:0032012)2.86036386
104synaptic transmission (GO:0007268)2.84442343
105neuromuscular process (GO:0050905)2.84214723
106detection of calcium ion (GO:0005513)2.83015251
107presynaptic membrane organization (GO:0097090)2.82078769
108neuronal ion channel clustering (GO:0045161)2.81650507
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.81133326
110positive regulation of neurotransmitter secretion (GO:0001956)2.80906684
111chemosensory behavior (GO:0007635)2.80682941
112positive regulation of neurotransmitter transport (GO:0051590)2.80182497
113potassium ion homeostasis (GO:0055075)2.79812391
114response to auditory stimulus (GO:0010996)2.79056140
115regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.78941642
116G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.78939319
117regulation of synaptic transmission (GO:0050804)2.78835977
118acidic amino acid transport (GO:0015800)2.77579573
119learning (GO:0007612)2.77358516
120fear response (GO:0042596)2.76708288
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.76689180
122positive regulation of synaptic transmission (GO:0050806)2.76676103
123dendritic spine organization (GO:0097061)2.76334071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.67779893
2GBX2_23144817_ChIP-Seq_PC3_Human3.47881236
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08351906
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02022981
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00117611
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72728855
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72728855
8REST_21632747_ChIP-Seq_MESCs_Mouse2.63220639
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62377672
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56558447
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53874195
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50822756
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48927663
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43363442
15DROSHA_22980978_ChIP-Seq_HELA_Human2.41718146
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.40269550
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.35441948
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.23154401
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.21697576
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19545248
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.13951870
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.13087295
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92346410
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88971929
25AR_21572438_ChIP-Seq_LNCaP_Human1.82791319
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82486796
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77399734
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75562948
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74535336
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70344455
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69878573
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69734345
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.68512953
34TAF15_26573619_Chip-Seq_HEK293_Human1.61110720
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59082190
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57770995
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50529291
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46816378
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.44793901
40ZNF274_21170338_ChIP-Seq_K562_Hela1.44451594
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38906581
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36017867
43P300_19829295_ChIP-Seq_ESCs_Human1.34014398
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32217447
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.31634988
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30411847
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30011633
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29983324
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.28459974
50AR_25329375_ChIP-Seq_VCAP_Human1.26758382
51STAT3_23295773_ChIP-Seq_U87_Human1.25430032
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25234177
53* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23291462
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.22951798
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22066291
56AR_19668381_ChIP-Seq_PC3_Human1.22007052
57* SMAD3_21741376_ChIP-Seq_EPCs_Human1.21826798
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19817003
59CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18563552
60* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18549048
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17917571
62IGF1R_20145208_ChIP-Seq_DFB_Human1.17609419
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.16512730
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14894737
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14275537
66AHR_22903824_ChIP-Seq_MCF-7_Human1.13393448
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.12454244
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.11982880
69TP53_20018659_ChIP-ChIP_R1E_Mouse1.11639790
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.11586453
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11299889
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10866471
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09997302
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.09164013
75KDM2B_26808549_Chip-Seq_K562_Human1.08728790
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08634648
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07979318
78OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07914761
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07270141
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06972964
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06743087
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06468569
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06413298
84TCF4_23295773_ChIP-Seq_U87_Human1.06098842
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.05671801
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05292163
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04997143
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04996840
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02921527
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.02637250
91* CTCF_27219007_Chip-Seq_Bcells_Human1.00130563
92SMAD4_21741376_ChIP-Seq_HESCs_Human0.98786835
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98687401
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97916763
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97228550
96RNF2_27304074_Chip-Seq_NSC_Mouse0.96485384
97* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95651457
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.95524258
99* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94899799
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94303904
101SMAD3_21741376_ChIP-Seq_HESCs_Human0.94212765
102BCAT_22108803_ChIP-Seq_LS180_Human0.94079834
103POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93446826
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93398564
105RUNX2_22187159_ChIP-Seq_PCA_Human0.92977930
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92294286
107VDR_22108803_ChIP-Seq_LS180_Human0.91368690
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90887994
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87022218
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86547338
111* TP53_16413492_ChIP-PET_HCT116_Human0.86351854
112TET1_21490601_ChIP-Seq_MESCs_Mouse0.85563964
113EP300_21415370_ChIP-Seq_HL-1_Mouse0.85537788
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85334931
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85334931
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83509993
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83013779
118JUN_21703547_ChIP-Seq_K562_Human0.82962671
119* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80530847
120SOX9_26525672_Chip-Seq_HEART_Mouse0.80419049
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78598969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.16879405
2MP0003880_abnormal_central_pattern4.62013330
3MP0004270_analgesia4.02051537
4MP0003635_abnormal_synaptic_transmissio3.94156203
5MP0001968_abnormal_touch/_nociception3.50023578
6MP0002063_abnormal_learning/memory/cond3.11264473
7MP0009745_abnormal_behavioral_response3.06735384
8MP0002064_seizures2.91705340
9MP0009046_muscle_twitch2.90024785
10MP0002734_abnormal_mechanical_nocicepti2.87569313
11MP0002735_abnormal_chemical_nociception2.82280740
12MP0002736_abnormal_nociception_after2.69458815
13MP0002272_abnormal_nervous_system2.66831789
14MP0005423_abnormal_somatic_nervous2.64086846
15MP0002572_abnormal_emotion/affect_behav2.56129328
16MP0001486_abnormal_startle_reflex2.40207700
17MP0002733_abnormal_thermal_nociception2.30431479
18MP0004858_abnormal_nervous_system2.21623895
19MP0001970_abnormal_pain_threshold2.12003630
20MP0001501_abnormal_sleep_pattern2.10833839
21MP0002067_abnormal_sensory_capabilities2.06433852
22MP0003329_amyloid_beta_deposits2.02267508
23MP0006276_abnormal_autonomic_nervous2.02103700
24MP0001440_abnormal_grooming_behavior1.96608200
25MP0009780_abnormal_chondrocyte_physiolo1.96027995
26MP0002184_abnormal_innervation1.91824395
27MP0002909_abnormal_adrenal_gland1.86869523
28MP0000778_abnormal_nervous_system1.81722739
29MP0002822_catalepsy1.81168303
30MP0008569_lethality_at_weaning1.79847477
31MP0004811_abnormal_neuron_physiology1.79557698
32MP0000955_abnormal_spinal_cord1.63212513
33MP0004924_abnormal_behavior1.59403524
34MP0005386_behavior/neurological_phenoty1.59403524
35MP0002557_abnormal_social/conspecific_i1.57666202
36MP0001984_abnormal_olfaction1.55356996
37MP0002882_abnormal_neuron_morphology1.50426961
38MP0003879_abnormal_hair_cell1.43023419
39MP0000751_myopathy1.41424198
40MP0002066_abnormal_motor_capabilities/c1.38895918
41MP0003633_abnormal_nervous_system1.37552706
42MP0005551_abnormal_eye_electrophysiolog1.37464105
43MP0004885_abnormal_endolymph1.34780053
44MP0005646_abnormal_pituitary_gland1.28307659
45MP0002837_dystrophic_cardiac_calcinosis1.21923647
46MP0002229_neurodegeneration1.21064208
47MP0003787_abnormal_imprinting1.18978413
48MP0001502_abnormal_circadian_rhythm1.18211512
49MP0004145_abnormal_muscle_electrophysio1.16651562
50MP0003631_nervous_system_phenotype1.14658555
51MP0005645_abnormal_hypothalamus_physiol1.11245876
52MP0004142_abnormal_muscle_tone1.11057542
53MP0003123_paternal_imprinting1.08655357
54MP0000013_abnormal_adipose_tissue1.06239298
55MP0003122_maternal_imprinting1.03327855
56MP0003634_abnormal_glial_cell1.03325452
57MP0002152_abnormal_brain_morphology1.02776009
58MP0001346_abnormal_lacrimal_gland0.98815188
59MP0001905_abnormal_dopamine_level0.98476610
60MP0001529_abnormal_vocalization0.98108126
61MP0004215_abnormal_myocardial_fiber0.93945202
62MP0005670_abnormal_white_adipose0.93931995
63MP0000920_abnormal_myelination0.93368704
64MP0002752_abnormal_somatic_nervous0.93039211
65MP0004085_abnormal_heartbeat0.90578577
66MP0002090_abnormal_vision0.89977398
67MP0010386_abnormal_urinary_bladder0.89870598
68MP0005623_abnormal_meninges_morphology0.89320746
69MP0005535_abnormal_body_temperature0.89091632
70MP0005409_darkened_coat_color0.88965482
71MP0006072_abnormal_retinal_apoptosis0.87797004
72MP0000604_amyloidosis0.87742913
73MP0002069_abnormal_eating/drinking_beha0.87202808
74MP0003283_abnormal_digestive_organ0.86526269
75MP0004233_abnormal_muscle_weight0.84351185
76MP0001188_hyperpigmentation0.83535728
77MP0001963_abnormal_hearing_physiology0.82912184
78MP0001485_abnormal_pinna_reflex0.82707679
79MP0008874_decreased_physiological_sensi0.81682448
80MP0000569_abnormal_digit_pigmentation0.81524019
81MP0004742_abnormal_vestibular_system0.80638793
82MP0004484_altered_response_of0.79959248
83MP0008872_abnormal_physiological_respon0.78282343
84MP0003632_abnormal_nervous_system0.77980903
85MP0008961_abnormal_basal_metabolism0.74924060
86MP0001177_atelectasis0.74590297
87MP0000534_abnormal_ureter_morphology0.73528498
88MP0003690_abnormal_glial_cell0.73197087
89MP0004130_abnormal_muscle_cell0.72430718
90MP0001348_abnormal_lacrimal_gland0.71674976
91MP0001299_abnormal_eye_distance/0.70275688
92MP0005253_abnormal_eye_physiology0.69000033
93MP0005499_abnormal_olfactory_system0.68964158
94MP0005394_taste/olfaction_phenotype0.68964158
95MP0000747_muscle_weakness0.67607173
96MP0003137_abnormal_impulse_conducting0.66555160
97MP0003075_altered_response_to0.66353667
98MP0002876_abnormal_thyroid_physiology0.62940809
99MP0002638_abnormal_pupillary_reflex0.61105604
100MP0000631_abnormal_neuroendocrine_gland0.60811275
101MP0004043_abnormal_pH_regulation0.60069918
102MP0005503_abnormal_tendon_morphology0.58936903
103MP0003385_abnormal_body_wall0.58518675
104MP0001986_abnormal_taste_sensitivity0.58296577
105MP0004510_myositis0.58266278
106MP0003861_abnormal_nervous_system0.57197845
107MP0004036_abnormal_muscle_relaxation0.57188654
108MP0003045_fibrosis0.56795864
109MP0005187_abnormal_penis_morphology0.56601617
110MP0001664_abnormal_digestion0.55559796
111MP0005620_abnormal_muscle_contractility0.55520535
112MP0010769_abnormal_survival0.55095746
113MP0001943_abnormal_respiration0.54234043
114MP0010770_preweaning_lethality0.53018594
115MP0002082_postnatal_lethality0.53018594
116MP0000026_abnormal_inner_ear0.51696362
117MP0003938_abnormal_ear_development0.51382235
118MP0010768_mortality/aging0.51307980
119MP0005171_absent_coat_pigmentation0.50095311
120MP0004084_abnormal_cardiac_muscle0.48116405
121MP0000639_abnormal_adrenal_gland0.46943121
122MP0003956_abnormal_body_size0.46024310

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.67814234
2Myokymia (HP:0002411)6.39470278
3Focal seizures (HP:0007359)5.39107334
4Action tremor (HP:0002345)4.99397873
5Visual hallucinations (HP:0002367)4.88887848
6Epileptic encephalopathy (HP:0200134)4.48586813
7Atonic seizures (HP:0010819)4.41443840
8Febrile seizures (HP:0002373)4.23926534
9Progressive cerebellar ataxia (HP:0002073)4.16578894
10Ulnar claw (HP:0001178)4.10760581
11Absence seizures (HP:0002121)4.09687844
12Obstructive sleep apnea (HP:0002870)4.05317905
13Supranuclear gaze palsy (HP:0000605)4.03101790
14Termporal pattern (HP:0011008)3.99150196
15Insidious onset (HP:0003587)3.99150196
16Dialeptic seizures (HP:0011146)3.69775799
17Generalized tonic-clonic seizures (HP:0002069)3.65855818
18Ankle clonus (HP:0011448)3.36815507
19Truncal ataxia (HP:0002078)3.09272096
20Impaired vibration sensation in the lower limbs (HP:0002166)3.00800951
21Depression (HP:0000716)2.99888152
22Poor eye contact (HP:0000817)2.95221644
23Broad-based gait (HP:0002136)2.94815014
24Urinary bladder sphincter dysfunction (HP:0002839)2.94252830
25Annular pancreas (HP:0001734)2.92940811
26Amblyopia (HP:0000646)2.88716648
27Dysmetria (HP:0001310)2.87182566
28Pheochromocytoma (HP:0002666)2.87043809
29Dysdiadochokinesis (HP:0002075)2.86901882
30Gaze-evoked nystagmus (HP:0000640)2.86745056
31Sleep apnea (HP:0010535)2.82710782
32Abnormal eating behavior (HP:0100738)2.80479035
33Mutism (HP:0002300)2.80253437
34Abnormal social behavior (HP:0012433)2.75350291
35Impaired social interactions (HP:0000735)2.75350291
36Anxiety (HP:0000739)2.73720568
37Hyperventilation (HP:0002883)2.72031532
38Hand muscle atrophy (HP:0009130)2.70518479
39Postural instability (HP:0002172)2.68127273
40Abnormality of the lower motor neuron (HP:0002366)2.67729570
41Urinary urgency (HP:0000012)2.65483267
42Cerebral inclusion bodies (HP:0100314)2.63909225
43Neurofibrillary tangles (HP:0002185)2.60920325
44Papilledema (HP:0001085)2.59128008
45Excessive salivation (HP:0003781)2.55559582
46Drooling (HP:0002307)2.55559582
47Genetic anticipation (HP:0003743)2.54000820
48Hammertoe (HP:0001765)2.51149694
49Upper limb amyotrophy (HP:0009129)2.51078397
50Distal upper limb amyotrophy (HP:0007149)2.51078397
51Spastic gait (HP:0002064)2.50362891
52Ventricular fibrillation (HP:0001663)2.47380815
53Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.46444553
54Neuroendocrine neoplasm (HP:0100634)2.43806425
55Epileptiform EEG discharges (HP:0011182)2.42564306
56Abnormality of the corticospinal tract (HP:0002492)2.42109318
57Hemiparesis (HP:0001269)2.39158732
58Cerebral hypomyelination (HP:0006808)2.37915161
59Progressive inability to walk (HP:0002505)2.37213863
60Akinesia (HP:0002304)2.36984126
61Scanning speech (HP:0002168)2.35808488
62Impaired smooth pursuit (HP:0007772)2.33756821
63EEG with generalized epileptiform discharges (HP:0011198)2.33596839
64Segmental peripheral demyelination/remyelination (HP:0003481)2.33414313
65Central scotoma (HP:0000603)2.29935497
66Torticollis (HP:0000473)2.28977986
67Lower limb amyotrophy (HP:0007210)2.27548553
68Lower limb muscle weakness (HP:0007340)2.26066921
69Onion bulb formation (HP:0003383)2.25669899
70Intention tremor (HP:0002080)2.25360982
71Bradykinesia (HP:0002067)2.20032548
72Diplopia (HP:0000651)2.19970388
73Abnormality of binocular vision (HP:0011514)2.19970388
74Steppage gait (HP:0003376)2.18495498
75Clonus (HP:0002169)2.18310512
76Muscle fiber splitting (HP:0003555)2.17060293
77Hypsarrhythmia (HP:0002521)2.15732893
78Postural tremor (HP:0002174)2.15170167
79Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14440161
80Degeneration of the lateral corticospinal tracts (HP:0002314)2.14440161
81Rapidly progressive (HP:0003678)2.12560557
82Tetraplegia (HP:0002445)2.12120151
83Peripheral hypomyelination (HP:0007182)2.10220055
84Insomnia (HP:0100785)2.07762890
85Focal dystonia (HP:0004373)2.06969443
86Megalencephaly (HP:0001355)2.05728144
87Absent speech (HP:0001344)2.05137168
88Stereotypic behavior (HP:0000733)2.04640399
89Spinal cord compression (HP:0002176)2.04625872
90Abnormality of the foot musculature (HP:0001436)2.04423389
91Incomplete penetrance (HP:0003829)2.03723792
92Hemiplegia (HP:0002301)2.03672634
93Dysmetric saccades (HP:0000641)2.03275592
94Abnormality of ocular smooth pursuit (HP:0000617)2.02872837
95Morphological abnormality of the pyramidal tract (HP:0002062)2.01899679
96Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.01047000
97Impaired vibratory sensation (HP:0002495)2.00857465
98Bronchomalacia (HP:0002780)2.00606414
99Fetal akinesia sequence (HP:0001989)1.99590754
100Prolonged QT interval (HP:0001657)1.98590834
101Hypoventilation (HP:0002791)1.96310363
102Polyphagia (HP:0002591)1.96145210
103Gait ataxia (HP:0002066)1.95075445
104Congenital stationary night blindness (HP:0007642)1.94685062
105Decreased motor nerve conduction velocity (HP:0003431)1.93145995
106Neuronal loss in central nervous system (HP:0002529)1.92739455
107Agitation (HP:0000713)1.90993643
108Inability to walk (HP:0002540)1.90783279
109Stridor (HP:0010307)1.89836653
110Abnormality of the vocal cords (HP:0008777)1.88213057
111Increased circulating renin level (HP:0000848)1.87692296
112Generalized myoclonic seizures (HP:0002123)1.87581911
113Difficulty running (HP:0009046)1.87084342
114Status epilepticus (HP:0002133)1.86519482
115Bundle branch block (HP:0011710)1.86283978
116Distal sensory impairment (HP:0002936)1.85683673
117Craniofacial dystonia (HP:0012179)1.84820548
118Hypoplasia of the brainstem (HP:0002365)1.84382052
119Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84382052
120Foot dorsiflexor weakness (HP:0009027)1.84169605
121Spinal muscular atrophy (HP:0007269)1.84106512
122Aplasia involving bones of the extremities (HP:0009825)1.83197178
123Aplasia involving bones of the upper limbs (HP:0009823)1.83197178
124Aplasia of the phalanges of the hand (HP:0009802)1.83197178
125Apathy (HP:0000741)1.81480230
126Abnormal EKG (HP:0003115)1.80653624
127Lower limb asymmetry (HP:0100559)1.80582707
128Atrioventricular block (HP:0001678)1.80353298
129Limb dystonia (HP:0002451)1.80235763
130Delusions (HP:0000746)1.80042375
131Amyotrophic lateral sclerosis (HP:0007354)1.78099256
132Failure to thrive in infancy (HP:0001531)1.77865910
133Abnormality of the musculature of the hand (HP:0001421)1.77708954
134Heart block (HP:0012722)1.75664790

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.66620502
2MAP3K93.89964843
3EPHA43.46317261
4MAP3K43.19534513
5MARK13.15736584
6MINK13.14019557
7MAP2K72.45821753
8KSR22.34462249
9PAK62.33802682
10NTRK12.17148824
11MAP2K42.05484455
12PRKD32.04730275
13DAPK22.01363784
14MAP3K121.99329519
15RIPK41.87637007
16NTRK21.73397926
17CAMKK11.70418029
18CDK51.56145375
19KSR11.52183243
20PNCK1.48893922
21LATS21.48698117
22LMTK21.48572217
23GRK51.44580940
24MAP3K21.41929587
25STK381.41681292
26CASK1.39111008
27PHKG21.36417770
28PHKG11.36417770
29MAPK131.30988498
30PLK21.27516396
31ARAF1.26642525
32DAPK11.25235133
33SIK21.24894446
34PRKCG1.16715630
35RET1.16349778
36TNIK1.11400448
37FES1.10228727
38CDK191.02691003
39PRPF4B1.01548449
40CAMK2A0.99673881
41UHMK10.98281673
42CAMKK20.97291161
43MAP3K130.95288574
44SGK2230.91659067
45SGK4940.91659067
46PAK30.91558268
47PTK2B0.88901134
48CDK140.86573976
49NEK60.84985897
50TYRO30.84475726
51PRKCH0.83068491
52CDK180.82759586
53FER0.81827837
54CAMK10.81636853
55CDK150.81277926
56STK110.80678336
57CAMK1G0.80483989
58WNK10.79445303
59CAMK2B0.76801068
60OXSR10.74160741
61MAPK120.73405026
62PINK10.72919594
63TAOK10.71723000
64WNK40.70626697
65PDK10.70092369
66CDK11A0.69468105
67DYRK1A0.68849152
68PDGFRA0.68756229
69MAP3K10.68728076
70DDR20.68177435
71MARK20.67464722
72RAF10.67409307
73STK390.66119183
74SGK20.64521188
75PDPK10.63674376
76CAMK40.61656361
77MAP2K10.60708259
78SGK10.60348467
79SCYL20.60036939
80CSNK1G20.58837202
81PKN10.56884907
82PRKCZ0.56744632
83SGK30.56276455
84BMPR20.56168353
85PRKCE0.55739722
86CDC42BPA0.55056767
87CAMK2D0.53299672
88FGFR20.52706878
89NME10.52706793
90ICK0.52302309
91TESK10.49596369
92DAPK30.48342001
93NEK10.48285653
94ALK0.47533050
95RPS6KA30.47121669
96MAPK100.46470130
97FYN0.44436353
98BRSK10.44237655
99MAP3K70.44117648
100TNK20.43851775
101MAP3K60.43185908
102PRKAA10.42570537
103CAMK2G0.42217050
104RPS6KA20.42198325
105RIPK10.41849584
106ROCK20.41169356
107FGR0.40926886
108ROCK10.38802150
109PRKG10.38645096
110BRAF0.38265230
111CSNK1E0.36777465
112LIMK10.35281948
113PTK20.35031921
114WNK30.34604832
115ERBB20.34278711
116PAK20.33956889
117AKT30.33685398
118PRKCA0.32738801
119PRKCB0.32252686
120PDK30.30287444
121PDK40.30287444

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.38418475
2Synaptic vesicle cycle_Homo sapiens_hsa047213.14978252
3Circadian entrainment_Homo sapiens_hsa047132.58250803
4Long-term potentiation_Homo sapiens_hsa047202.57710736
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53460314
6GABAergic synapse_Homo sapiens_hsa047272.52390013
7Olfactory transduction_Homo sapiens_hsa047402.51492758
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.44164544
9Glutamatergic synapse_Homo sapiens_hsa047242.41192197
10Morphine addiction_Homo sapiens_hsa050322.28960415
11Amphetamine addiction_Homo sapiens_hsa050312.20958897
12Salivary secretion_Homo sapiens_hsa049702.14309817
13Dopaminergic synapse_Homo sapiens_hsa047282.08978427
14Insulin secretion_Homo sapiens_hsa049112.02707434
15Cholinergic synapse_Homo sapiens_hsa047251.87060873
16Gastric acid secretion_Homo sapiens_hsa049711.85734012
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78835873
18Taste transduction_Homo sapiens_hsa047421.75167061
19Renin secretion_Homo sapiens_hsa049241.73418291
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70402793
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67922747
22Long-term depression_Homo sapiens_hsa047301.62438739
23Oxytocin signaling pathway_Homo sapiens_hsa049211.61445000
24Serotonergic synapse_Homo sapiens_hsa047261.58134650
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54437085
26Calcium signaling pathway_Homo sapiens_hsa040201.50018446
27GnRH signaling pathway_Homo sapiens_hsa049121.46688422
28Vitamin B6 metabolism_Homo sapiens_hsa007501.43034519
29Gap junction_Homo sapiens_hsa045401.37448021
30Phototransduction_Homo sapiens_hsa047441.35981589
31Cocaine addiction_Homo sapiens_hsa050301.35428438
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32770194
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29819663
34Collecting duct acid secretion_Homo sapiens_hsa049661.28880754
35cAMP signaling pathway_Homo sapiens_hsa040241.21836594
36Type II diabetes mellitus_Homo sapiens_hsa049301.21613290
37Glioma_Homo sapiens_hsa052141.17345423
38Axon guidance_Homo sapiens_hsa043601.16913051
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16584800
40Estrogen signaling pathway_Homo sapiens_hsa049151.16213603
41Cardiac muscle contraction_Homo sapiens_hsa042601.07955669
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07142324
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05234166
44ErbB signaling pathway_Homo sapiens_hsa040121.02552039
45Dorso-ventral axis formation_Homo sapiens_hsa043201.02349569
46Melanogenesis_Homo sapiens_hsa049161.01314285
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.95934286
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91221530
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89761915
50Vibrio cholerae infection_Homo sapiens_hsa051100.89690366
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87576497
52Oocyte meiosis_Homo sapiens_hsa041140.87219622
53Pancreatic secretion_Homo sapiens_hsa049720.86572013
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.84290358
55Dilated cardiomyopathy_Homo sapiens_hsa054140.84169322
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80348610
57Thyroid hormone synthesis_Homo sapiens_hsa049180.79040918
58Choline metabolism in cancer_Homo sapiens_hsa052310.75743201
59VEGF signaling pathway_Homo sapiens_hsa043700.75277388
60Fatty acid biosynthesis_Homo sapiens_hsa000610.72951692
61Glucagon signaling pathway_Homo sapiens_hsa049220.69236447
62Nitrogen metabolism_Homo sapiens_hsa009100.69228078
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69146520
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.68974942
65MAPK signaling pathway_Homo sapiens_hsa040100.67614931
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66547505
67Ras signaling pathway_Homo sapiens_hsa040140.62077336
68mTOR signaling pathway_Homo sapiens_hsa041500.61919039
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61265757
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57873878
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.57370908
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57063835
73Rap1 signaling pathway_Homo sapiens_hsa040150.56677716
74AMPK signaling pathway_Homo sapiens_hsa041520.55421893
75Insulin signaling pathway_Homo sapiens_hsa049100.55012683
76Circadian rhythm_Homo sapiens_hsa047100.53311277
77Alzheimers disease_Homo sapiens_hsa050100.51940512
78Endocytosis_Homo sapiens_hsa041440.51558432
79Inositol phosphate metabolism_Homo sapiens_hsa005620.51490550
80Hippo signaling pathway_Homo sapiens_hsa043900.51458860
81Endometrial cancer_Homo sapiens_hsa052130.49053919
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48097564
83Bile secretion_Homo sapiens_hsa049760.47174542
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46714652
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46543618
86Renal cell carcinoma_Homo sapiens_hsa052110.45173781
87Prion diseases_Homo sapiens_hsa050200.43908933
88Arginine and proline metabolism_Homo sapiens_hsa003300.43022822
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40543239
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40517646
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40256366
92Non-small cell lung cancer_Homo sapiens_hsa052230.40004352
93Histidine metabolism_Homo sapiens_hsa003400.39536704
94Wnt signaling pathway_Homo sapiens_hsa043100.39073795
95Alcoholism_Homo sapiens_hsa050340.37194108
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.34980670
97ECM-receptor interaction_Homo sapiens_hsa045120.34151196
98African trypanosomiasis_Homo sapiens_hsa051430.33749350
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32122237
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31893013
101beta-Alanine metabolism_Homo sapiens_hsa004100.31584604
102Mineral absorption_Homo sapiens_hsa049780.31445004
103Ovarian steroidogenesis_Homo sapiens_hsa049130.30825738
104Protein digestion and absorption_Homo sapiens_hsa049740.30748334
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30043655
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29794484
107PPAR signaling pathway_Homo sapiens_hsa033200.29618037
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29611047
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29416767
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.29070252
111Focal adhesion_Homo sapiens_hsa045100.28921372
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28551738
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25339207
114Tight junction_Homo sapiens_hsa045300.25212605
115Chemokine signaling pathway_Homo sapiens_hsa040620.24834014

Most similar genes based on co-expression Upload to Enrichr

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