HSPA12B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)6.62068979
2cardiac myofibril assembly (GO:0055003)6.27840794
3sarcomere organization (GO:0045214)5.92164860
4myofibril assembly (GO:0030239)5.70839740
5vascular endothelial growth factor signaling pathway (GO:0038084)5.70768752
6low-density lipoprotein particle clearance (GO:0034383)5.05100763
7muscle filament sliding (GO:0030049)4.99757765
8actin-myosin filament sliding (GO:0033275)4.99757765
9transcytosis (GO:0045056)4.93399683
10blood vessel maturation (GO:0001955)4.91770215
11retina vasculature morphogenesis in camera-type eye (GO:0061299)4.90488309
12heart trabecula formation (GO:0060347)4.76881815
13plasma membrane repair (GO:0001778)4.73079564
14ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.65220411
15lymphangiogenesis (GO:0001946)4.58572771
16triglyceride catabolic process (GO:0019433)4.58196074
17cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.57090554
18regulation of relaxation of muscle (GO:1901077)4.56411629
19surfactant homeostasis (GO:0043129)4.46327242
20cardiac muscle tissue morphogenesis (GO:0055008)4.45193247
21endothelium development (GO:0003158)4.43289935
22actin-mediated cell contraction (GO:0070252)4.41672333
23bundle of His cell to Purkinje myocyte communication (GO:0086069)4.39901115
24cardiac muscle cell development (GO:0055013)4.35163177
25regulation of endothelial cell differentiation (GO:0045601)4.32249847
26acylglycerol catabolic process (GO:0046464)4.25668941
27neutral lipid catabolic process (GO:0046461)4.25668941
28actomyosin structure organization (GO:0031032)4.24214527
29cardiac muscle contraction (GO:0060048)4.17424313
30cardiac cell development (GO:0055006)4.17420609
31ovulation from ovarian follicle (GO:0001542)4.11474284
32venous blood vessel morphogenesis (GO:0048845)4.06554430
33positive regulation of vasculogenesis (GO:2001214)4.05909654
34muscle tissue morphogenesis (GO:0060415)4.05275072
35negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.99102068
36regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.96039274
37embryonic heart tube development (GO:0035050)3.95876259
38negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.95184293
39regulation of actin filament-based movement (GO:1903115)3.93680020
40regulation of sarcomere organization (GO:0060297)3.92854965
41morphogenesis of an endothelium (GO:0003159)3.86163713
42endothelial tube morphogenesis (GO:0061154)3.86163713
43regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.80434115
44negative regulation of nitric-oxide synthase activity (GO:0051001)3.79009195
45cell migration involved in heart development (GO:0060973)3.75872890
46NADH metabolic process (GO:0006734)3.72108993
47negative regulation of potassium ion transmembrane transport (GO:1901380)3.70138670
48ventricular trabecula myocardium morphogenesis (GO:0003222)3.68439911
49adult heart development (GO:0007512)3.62114048
50regulation of skeletal muscle contraction (GO:0014819)3.61714706
51trabecula formation (GO:0060343)3.60478021
52negative regulation of blood vessel endothelial cell migration (GO:0043537)3.58865580
53glomerular filtration (GO:0003094)3.57015619
54endothelial cell differentiation (GO:0045446)3.55240313
55chemical homeostasis within a tissue (GO:0048875)3.54039028
56angiogenesis involved in wound healing (GO:0060055)3.52519805
57cardiac muscle hypertrophy (GO:0003300)3.52270374
58positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.49303415
59regulation of vasculogenesis (GO:2001212)3.47456286
60basement membrane organization (GO:0071711)3.46914611
61tricarboxylic acid cycle (GO:0006099)3.44070517
62heart contraction (GO:0060047)3.41592303
63heart process (GO:0003015)3.41592303
64patterning of blood vessels (GO:0001569)3.38586385
65adherens junction assembly (GO:0034333)3.37408970
66vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.36270923
67extracellular fibril organization (GO:0043206)3.33630722
68regulation of cardioblast differentiation (GO:0051890)3.32982608
69striated muscle hypertrophy (GO:0014897)3.32699174
70regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.31930078
71regulation of the force of heart contraction (GO:0002026)3.31790700
72actin filament-based movement (GO:0030048)3.30471796
73regulation of striated muscle contraction (GO:0006942)3.30243412
74vasculogenesis (GO:0001570)3.28929764
75heart trabecula morphogenesis (GO:0061384)3.27969771
76protein heterotrimerization (GO:0070208)3.24849370
77axon extension involved in axon guidance (GO:0048846)3.24767660
78neuron projection extension involved in neuron projection guidance (GO:1902284)3.24767660
79negative regulation of striated muscle cell apoptotic process (GO:0010664)3.23555806
80striated muscle contraction (GO:0006941)3.23461666
81ventricular cardiac muscle cell action potential (GO:0086005)3.22888097
82renal filtration (GO:0097205)3.22658168
83negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.21243344
84regulation of cell communication by electrical coupling (GO:0010649)3.16369468
85carnitine shuttle (GO:0006853)3.14403137
86negative regulation of endothelial cell migration (GO:0010596)3.12211694
87regulation of sequestering of triglyceride (GO:0010889)3.11005634
88cellular response to epinephrine stimulus (GO:0071872)3.10481908
89positive regulation of lipoprotein lipase activity (GO:0051006)3.09883005
90positive regulation of triglyceride lipase activity (GO:0061365)3.09883005
91negative regulation of platelet activation (GO:0010544)3.09389320
92glycerolipid catabolic process (GO:0046503)3.08049798
93negative regulation of cardiac muscle hypertrophy (GO:0010614)3.07858982
94cGMP-mediated signaling (GO:0019934)3.06499324
95focal adhesion assembly (GO:0048041)3.04575138
96cell-substrate adherens junction assembly (GO:0007045)3.04575138
97cAMP biosynthetic process (GO:0006171)3.04127439
98fatty acid transmembrane transport (GO:1902001)3.03332918
99endothelial cell morphogenesis (GO:0001886)3.00592339
100regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.00142255
101coronary vasculature morphogenesis (GO:0060977)2.99294457
102sarcoplasmic reticulum calcium ion transport (GO:0070296)2.99047957
103regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.98722028
104endothelial cell chemotaxis (GO:0035767)2.94575248
105muscle hypertrophy (GO:0014896)2.94027362
106positive regulation of endothelial cell differentiation (GO:0045603)2.91952368
107sprouting angiogenesis (GO:0002040)2.91752769
108cardiac muscle tissue development (GO:0048738)2.90859621
109endocrine hormone secretion (GO:0060986)2.90729184
110trabecula morphogenesis (GO:0061383)2.89333085
111outflow tract septum morphogenesis (GO:0003148)2.89281110
112cell migration involved in sprouting angiogenesis (GO:0002042)2.88490418
113regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.87611135
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85878251
115regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.85432348
116cardiac chamber formation (GO:0003207)2.85209066
117skeletal muscle contraction (GO:0003009)2.83774168
118diacylglycerol metabolic process (GO:0046339)2.83416876
119regulation of cardiac muscle contraction (GO:0055117)2.83335399
120positive regulation of glomerulus development (GO:0090193)2.82884910
121blood vessel remodeling (GO:0001974)2.82076967
122regulation of membrane repolarization (GO:0060306)2.81599511
123fibril organization (GO:0097435)2.81345254
124negative regulation of muscle hypertrophy (GO:0014741)2.80855834
125regulation of heart rate (GO:0002027)2.80723770
126glomerular basement membrane development (GO:0032836)2.80633635
127negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.79642455
128cell-substrate junction assembly (GO:0007044)2.79450031
129regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.79409095
130negative regulation of DNA biosynthetic process (GO:2000279)2.78925124
131positive regulation of receptor recycling (GO:0001921)2.76519313
132response to dietary excess (GO:0002021)2.76183654
133cell volume homeostasis (GO:0006884)2.76017389
134creatine metabolic process (GO:0006600)2.69127724
135positive regulation of protein kinase C signaling (GO:0090037)2.66976444
136barbed-end actin filament capping (GO:0051016)2.64806402
137activation of protein kinase A activity (GO:0034199)2.63934605
138fatty acid homeostasis (GO:0055089)2.59558646
139protein localization to cell surface (GO:0034394)2.59405739
140peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.57409282
141response to epinephrine (GO:0071871)2.57349051
142positive regulation of endothelial cell apoptotic process (GO:2000353)2.55837034
143phagocytosis, recognition (GO:0006910)2.53242529
144atrioventricular valve morphogenesis (GO:0003181)2.53177638
145mRNA transcription from RNA polymerase II promoter (GO:0042789)2.51932128
146negative regulation of smooth muscle cell proliferation (GO:0048662)2.51580362
147negative regulation of vascular permeability (GO:0043116)2.50158757
148regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.49624984
149regulation of cholesterol storage (GO:0010885)2.48206595
150negative regulation of cartilage development (GO:0061037)2.47911284
151positive regulation of urine volume (GO:0035810)2.46561099
152negative regulation of erythrocyte differentiation (GO:0045647)2.46510273
153muscle contraction (GO:0006936)2.45287254
154stress fiber assembly (GO:0043149)2.45281862
155polyol transport (GO:0015791)2.44866641
156blood vessel endothelial cell migration (GO:0043534)2.43730861
157wound healing, spreading of epidermal cells (GO:0035313)2.43340864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.56664920
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.59568367
3EP300_21415370_ChIP-Seq_HL-1_Mouse4.43157156
4GATA2_21666600_ChIP-Seq_HMVEC_Human3.69609292
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.58532706
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.45709794
7TBX20_22328084_ChIP-Seq_HEART_Mouse3.11576891
8TBX20_22080862_ChIP-Seq_HEART_Mouse3.11576891
9CDX2_19796622_ChIP-Seq_MESCs_Mouse3.02485877
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.97178897
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.86667871
12* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.79202143
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.71450185
14MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.32975627
15LXR_22292898_ChIP-Seq_THP-1_Human2.31039311
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29197218
17* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.24546443
18CLOCK_20551151_ChIP-Seq_293T_Human2.23914173
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18821113
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.16941093
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.15388632
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13100670
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.09301095
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.09027817
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06499871
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06499871
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06153597
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.97476009
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.95308048
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.94192176
31GATA4_21415370_ChIP-Seq_HL-1_Mouse1.91208389
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.86861074
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83792192
34KDM2B_26808549_Chip-Seq_K562_Human1.80552476
35* ELK3_25401928_ChIP-Seq_HUVEC_Human1.78217217
36* CJUN_26792858_Chip-Seq_BT549_Human1.73946143
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71385473
38DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.69611292
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69046446
40EZH2_22144423_ChIP-Seq_EOC_Human1.64568108
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.63620725
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62299984
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60919480
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59803912
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58319123
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57061619
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.55358075
48RACK7_27058665_Chip-Seq_MCF-7_Human1.54242945
49GATA1_22025678_ChIP-Seq_K562_Human1.54209569
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53736123
51KDM2B_26808549_Chip-Seq_DND41_Human1.53678440
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53275265
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52977117
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52065651
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.52007267
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.48470733
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.48043816
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47103681
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45565321
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45565321
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45565321
62NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.45063086
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43373497
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42949690
65ISL1_27105846_Chip-Seq_CPCs_Mouse1.42774041
66* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42654659
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40988872
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40059159
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39913401
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39193046
71DROSHA_22980978_ChIP-Seq_HELA_Human1.39027653
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37022157
73GATA1_19941826_ChIP-Seq_K562_Human1.36102883
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35080053
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32158836
76SMC4_20622854_ChIP-Seq_HELA_Human1.31830689
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30274438
78SCL_19346495_ChIP-Seq_HPC-7_Human1.30179507
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.30123764
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29925208
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29688810
82AHR_22903824_ChIP-Seq_MCF-7_Human1.29000715
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.28794904
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28447311
85ZNF263_19887448_ChIP-Seq_K562_Human1.26934651
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26184404
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26039013
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25806353
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25544610
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.25336260
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25224579
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24511917
93* P68_20966046_ChIP-Seq_HELA_Human1.23653967
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22299951
95LXR_22158963_ChIP-Seq_LIVER_Mouse1.20866046
96EZH2_27294783_Chip-Seq_ESCs_Mouse1.20134514
97* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19251745
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19082881
99* TCF7_22412390_ChIP-Seq_EML_Mouse1.18596610
100* TET1_21451524_ChIP-Seq_MESCs_Mouse1.17706516
101JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17189027
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.16875949
103BRD4_25478319_ChIP-Seq_HGPS_Human1.16340487
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16217465
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.15354529
106RAD21_21589869_ChIP-Seq_MESCs_Mouse1.15278487
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14068023
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14068023
109ESR2_21235772_ChIP-Seq_MCF-7_Human1.13261992
110* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11235955
111SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10655256
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10466374
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09401106
114TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08887019
115PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.08570420
116* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07113287
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06151020
118MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05559418
119* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05109304
120BCAT_22108803_ChIP-Seq_LS180_Human1.04433497
121* TET1_21490601_ChIP-Seq_MESCs_Mouse1.03822228
122SA1_22415368_ChIP-Seq_MEFs_Mouse1.02176538
123TP53_23651856_ChIP-Seq_MEFs_Mouse1.01969902
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01920485
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00907169
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99845701
127MYC_27129775_Chip-Seq_CORNEA_Mouse0.98749334
128JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98369463
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97904912
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97455390
131KDM2B_26808549_Chip-Seq_JURKAT_Human0.96299990
132SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95512693
133VDR_21846776_ChIP-Seq_THP-1_Human0.95431021
134STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94894734
135RING1B_27294783_Chip-Seq_ESCs_Mouse0.94162438
136SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91514384
137SPI1_23127762_ChIP-Seq_K562_Human0.90475196
138JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87405722
139NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86328587
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.86091427
141SUZ12_27294783_Chip-Seq_ESCs_Mouse0.83553267
142CTCF_27219007_Chip-Seq_Bcells_Human0.82297790
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82260245
144RUNX_20019798_ChIP-Seq_JUKART_Human0.81999847
145* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81399747
146UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78916056
147* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78210732
148SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77771164
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.77094118
150GATA1_19941827_ChIP-Seq_MEL_Mouse0.76260749
151DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76171075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.89113749
2MP0010368_abnormal_lymphatic_system4.70767751
3MP0002837_dystrophic_cardiac_calcinosis4.44299291
4MP0001879_abnormal_lymphatic_vessel4.11028318
5MP0000751_myopathy3.79444818
6MP0004215_abnormal_myocardial_fiber3.61311853
7MP0004272_abnormal_basement_membrane3.21215287
8MP0004036_abnormal_muscle_relaxation3.20707339
9MP0005330_cardiomyopathy2.75081957
10MP0003646_muscle_fatigue2.74572717
11MP0005167_abnormal_blood-brain_barrier2.70043927
12MP0000749_muscle_degeneration2.68766354
13MP0003828_pulmonary_edema2.65930249
14MP0006138_congestive_heart_failure2.57189687
15MP0002972_abnormal_cardiac_muscle2.50617843
16MP0005385_cardiovascular_system_phenoty2.41093446
17MP0001544_abnormal_cardiovascular_syste2.41093446
18MP0008775_abnormal_heart_ventricle2.38301692
19MP0008438_abnormal_cutaneous_collagen2.36143694
20MP0003279_aneurysm2.26519520
21MP0010630_abnormal_cardiac_muscle2.19052415
22MP0005620_abnormal_muscle_contractility2.13279557
23MP0005670_abnormal_white_adipose2.10024504
24MP0004087_abnormal_muscle_fiber2.08803438
25MP0004484_altered_response_of2.05406887
26MP0000750_abnormal_muscle_regeneration1.92881238
27MP0002971_abnormal_brown_adipose1.88730592
28MP0004085_abnormal_heartbeat1.85962960
29MP0003137_abnormal_impulse_conducting1.84422027
30MP0010030_abnormal_orbit_morphology1.82136319
31MP0002127_abnormal_cardiovascular_syste1.80517373
32MP0000767_abnormal_smooth_muscle1.74301715
33MP0004130_abnormal_muscle_cell1.72861101
34MP0000343_altered_response_to1.70765633
35MP0002106_abnormal_muscle_physiology1.67922935
36MP0005503_abnormal_tendon_morphology1.66254663
37MP0004147_increased_porphyrin_level1.65364962
38MP0003950_abnormal_plasma_membrane1.64916553
39MP0006054_spinal_hemorrhage1.63133053
40MP0005623_abnormal_meninges_morphology1.51651862
41MP0005275_abnormal_skin_tensile1.48811146
42MP0005369_muscle_phenotype1.46106347
43MP0003567_abnormal_fetal_cardiomyocyte1.40579520
44MP0001958_emphysema1.38688186
45MP0000759_abnormal_skeletal_muscle1.37940886
46MP0004145_abnormal_muscle_electrophysio1.37590497
47MP0009697_abnormal_copulation1.29623630
48MP0000266_abnormal_heart_morphology1.28684337
49MP0003724_increased_susceptibility_to1.27756125
50MP0002128_abnormal_blood_circulation1.26448396
51MP0003122_maternal_imprinting1.25945500
52MP0002933_joint_inflammation1.24517324
53MP0004510_myositis1.22669345
54MP0005165_increased_susceptibility_to1.20826918
55MP0003385_abnormal_body_wall1.20730932
56MP0002332_abnormal_exercise_endurance1.16365104
57MP0005666_abnormal_adipose_tissue1.16243771
58MP0003566_abnormal_cell_adhesion1.15184700
59MP0005595_abnormal_vascular_smooth1.09889513
60MP0002925_abnormal_cardiovascular_devel1.09093551
61MP0009780_abnormal_chondrocyte_physiolo1.08819226
62MP0002269_muscular_atrophy1.07826582
63MP0000013_abnormal_adipose_tissue1.06808754
64MP0004782_abnormal_surfactant_physiolog1.05670826
65MP0003091_abnormal_cell_migration1.05288002
66MP0002970_abnormal_white_adipose0.98706536
67MP0003959_abnormal_lean_body0.96989415
68MP0002108_abnormal_muscle_morphology0.96149377
69MP0001614_abnormal_blood_vessel0.95888495
70MP0005375_adipose_tissue_phenotype0.94132183
71MP0003221_abnormal_cardiomyocyte_apopto0.93100752
72MP0001661_extended_life_span0.92254099
73MP0002295_abnormal_pulmonary_circulatio0.91227093
74MP0010329_abnormal_lipoprotein_level0.91008004
75MP0005334_abnormal_fat_pad0.90582303
76MP0003705_abnormal_hypodermis_morpholog0.89756771
77MP0000249_abnormal_blood_vessel0.87970496
78MP0000733_abnormal_muscle_development0.87036714
79MP0005535_abnormal_body_temperature0.85247568
80MP0002396_abnormal_hematopoietic_system0.82859227
81MP0000003_abnormal_adipose_tissue0.82713773
82MP0003690_abnormal_glial_cell0.82316142
83MP0000230_abnormal_systemic_arterial0.82133509
84MP0001849_ear_inflammation0.77372722
85MP0000747_muscle_weakness0.71746080
86MP0000534_abnormal_ureter_morphology0.70379114
87MP0001188_hyperpigmentation0.68145547
88MP0005171_absent_coat_pigmentation0.68132967
89MP0003941_abnormal_skin_development0.67613730
90MP0009115_abnormal_fat_cell0.66739295
91MP0001175_abnormal_lung_morphology0.66049540
92MP0009384_cardiac_valve_regurgitation0.65821281
93MP0004808_abnormal_hematopoietic_stem0.65805625
94MP0009250_abnormal_appendicular_skeleto0.65391309
95MP0008995_early_reproductive_senescence0.64512920
96MP0005409_darkened_coat_color0.64510119
97MP0005448_abnormal_energy_balance0.64112018
98MP0003935_abnormal_craniofacial_develop0.63433084
99MP0001270_distended_abdomen0.63427740
100MP0002118_abnormal_lipid_homeostasis0.62721577
101MP0002249_abnormal_larynx_morphology0.61758689
102MP0006036_abnormal_mitochondrial_physio0.60952542
103MP0002796_impaired_skin_barrier0.60945561
104MP0004233_abnormal_muscle_weight0.60932775
105MP0001784_abnormal_fluid_regulation0.60614214
106MP0002060_abnormal_skin_morphology0.59993646
107MP0005023_abnormal_wound_healing0.59258410
108MP0004858_abnormal_nervous_system0.59200134
109MP0003984_embryonic_growth_retardation0.55932584
110MP0003942_abnormal_urinary_system0.55807127
111MP0002009_preneoplasia0.55636890
112MP0005508_abnormal_skeleton_morphology0.54699180
113MP0002088_abnormal_embryonic_growth/wei0.54314513
114MP0005388_respiratory_system_phenotype0.54306221
115MP0002133_abnormal_respiratory_system0.54306221
116MP0005452_abnormal_adipose_tissue0.53742572
117MP0003948_abnormal_gas_homeostasis0.53409968
118MP0000049_abnormal_middle_ear0.52309444
119MP0003868_abnormal_feces_composition0.52158177
120MP0003075_altered_response_to0.51921200
121MP0005164_abnormal_response_to0.51850320
122MP0005058_abnormal_lysosome_morphology0.51361836
123MP0002638_abnormal_pupillary_reflex0.50941541
124MP0004883_abnormal_blood_vessel0.48425496
125MP0004185_abnormal_adipocyte_glucose0.45448038
126MP0005187_abnormal_penis_morphology0.45296135
127MP0009278_abnormal_bone_marrow0.44845527

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.06197432
2Ventricular tachycardia (HP:0004756)5.99361869
3Atrial fibrillation (HP:0005110)5.44937082
4Muscle fiber splitting (HP:0003555)5.33233544
5Primary atrial arrhythmia (HP:0001692)5.08947364
6Supraventricular arrhythmia (HP:0005115)5.03694515
7Supraventricular tachycardia (HP:0004755)4.92603213
8Lipoatrophy (HP:0100578)4.89706968
9Abnormality of the left ventricular outflow tract (HP:0011103)4.61196719
10Subaortic stenosis (HP:0001682)4.61196719
11Increased connective tissue (HP:0009025)4.56484825
12Exercise-induced muscle cramps (HP:0003710)4.47935050
13Calf muscle hypertrophy (HP:0008981)4.32583898
14Muscle fiber inclusion bodies (HP:0100299)4.26077260
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.21328176
16Nemaline bodies (HP:0003798)4.19014731
17Round ear (HP:0100830)3.94740241
18Abnormality of the calf musculature (HP:0001430)3.88578250
19Dilated cardiomyopathy (HP:0001644)3.78034000
20Muscle hypertrophy of the lower extremities (HP:0008968)3.76619372
21Distal arthrogryposis (HP:0005684)3.71435948
22Hyporeflexia of lower limbs (HP:0002600)3.71356055
23Right ventricular cardiomyopathy (HP:0011663)3.70866332
24Prolonged QT interval (HP:0001657)3.63242859
25Pulmonary artery stenosis (HP:0004415)3.62768557
26Exercise-induced myalgia (HP:0003738)3.55644260
27Bundle branch block (HP:0011710)3.45979449
28Broad metatarsal (HP:0001783)3.45602975
29Palpitations (HP:0001962)3.42860263
30Oligomenorrhea (HP:0000876)3.21990038
31Type 1 muscle fiber predominance (HP:0003803)3.20069853
32Hematochezia (HP:0002573)3.18985147
33Centrally nucleated skeletal muscle fibers (HP:0003687)3.16260248
34Polycythemia (HP:0001901)3.13323473
35Syncope (HP:0001279)3.11957663
36Heart block (HP:0012722)3.11587352
37Myotonia (HP:0002486)3.01509018
38Abnormal atrioventricular conduction (HP:0005150)2.98362048
39Ulnar deviation of the wrist (HP:0003049)2.94392183
40Myoglobinuria (HP:0002913)2.93860936
41Distal lower limb muscle weakness (HP:0009053)2.93471590
42Spontaneous hematomas (HP:0007420)2.92233116
43EMG: myopathic abnormalities (HP:0003458)2.91287276
44Increased variability in muscle fiber diameter (HP:0003557)2.87091765
45Acanthosis nigricans (HP:0000956)2.82430622
46Atrioventricular block (HP:0001678)2.81694780
47Asymmetry of the thorax (HP:0001555)2.79711096
48Myopathic facies (HP:0002058)2.78569808
49Abnormality of skeletal muscle fiber size (HP:0012084)2.78267747
50Cerebral aneurysm (HP:0004944)2.67101380
51Ventricular arrhythmia (HP:0004308)2.64911078
52Abnormal EKG (HP:0003115)2.63542798
53Spinal rigidity (HP:0003306)2.63011155
54Lymphangioma (HP:0100764)2.62410865
55Hypertriglyceridemia (HP:0002155)2.61832237
56Asymmetric septal hypertrophy (HP:0001670)2.61305127
57Difficulty running (HP:0009046)2.59831411
58Protrusio acetabuli (HP:0003179)2.56707805
59Bulbar palsy (HP:0001283)2.54532563
60Calcaneovalgus deformity (HP:0001848)2.51376634
61Esophageal varix (HP:0002040)2.48310873
62Obstructive sleep apnea (HP:0002870)2.45437423
63Hemorrhage of the eye (HP:0011885)2.42576372
64Areflexia of lower limbs (HP:0002522)2.42428661
65Complement deficiency (HP:0004431)2.37724365
66Left ventricular hypertrophy (HP:0001712)2.35097228
67Nonimmune hydrops fetalis (HP:0001790)2.32917353
68Rhabdomyolysis (HP:0003201)2.30842568
69Mildly elevated creatine phosphokinase (HP:0008180)2.27838404
70Ventricular fibrillation (HP:0001663)2.27741398
71Venous abnormality (HP:0002624)2.27225925
72Visceral angiomatosis (HP:0100761)2.26738710
73Premature rupture of membranes (HP:0001788)2.26625643
74Turricephaly (HP:0000262)2.25692335
75Rimmed vacuoles (HP:0003805)2.25250976
76Difficulty climbing stairs (HP:0003551)2.24808339
77Abnormality of complement system (HP:0005339)2.20563294
78Ankle contracture (HP:0006466)2.17365639
79Pancreatic islet-cell hyperplasia (HP:0004510)2.15625359
80Neonatal death (HP:0003811)2.15167578
81Hemangiomatosis (HP:0007461)2.15064197
82Abnormality of the 4th metacarpal (HP:0010012)2.14996106
83Mitral valve prolapse (HP:0001634)2.14307595
84Foot dorsiflexor weakness (HP:0009027)2.12536444
85Deformed tarsal bones (HP:0008119)2.11557121
86Muscle stiffness (HP:0003552)2.11162725
87Abnormality of the foot musculature (HP:0001436)2.10211448
88Wrist flexion contracture (HP:0001239)2.08086212
89Skull defect (HP:0001362)2.04896925
90Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03401332
91Short 4th metacarpal (HP:0010044)2.03401332
92Hypoglycemic coma (HP:0001325)2.02091906
93Scapular winging (HP:0003691)2.01855278
94Hypoplastic left heart (HP:0004383)2.01385460
95Lower limb amyotrophy (HP:0007210)2.00652972
96Cavernous hemangioma (HP:0001048)2.00252121
97Vascular tortuosity (HP:0004948)1.99547754
98Distal lower limb amyotrophy (HP:0008944)1.97630639
99Insulin resistance (HP:0000855)1.96135114
100Congenital, generalized hypertrichosis (HP:0004540)1.96113184
101Frequent falls (HP:0002359)1.95599908
102Limited hip movement (HP:0008800)1.94871388
103Hypoplasia of the iris (HP:0007676)1.94362930
104Cervical subluxation (HP:0003308)1.93770470
105Follicular hyperkeratosis (HP:0007502)1.92320709
106Ectopia lentis (HP:0001083)1.92098671
107Malignant hyperthermia (HP:0002047)1.92021496
108Bladder diverticulum (HP:0000015)1.90838649
109Back pain (HP:0003418)1.90659886
110Hypoplastic ischia (HP:0003175)1.90575293
111Fragile skin (HP:0001030)1.90285299
112Aortic dissection (HP:0002647)1.88428418
113Gowers sign (HP:0003391)1.87679763
114Joint hemorrhage (HP:0005261)1.85907925
115Joint stiffness (HP:0001387)1.85679640
116Bradycardia (HP:0001662)1.85522137
117Hepatic necrosis (HP:0002605)1.85289808
118Generalized muscle weakness (HP:0003324)1.84361829
119Congestive heart failure (HP:0001635)1.84089005
120Palmoplantar keratoderma (HP:0000982)1.82972218
121Neck muscle weakness (HP:0000467)1.82781121
122Abnormality of the calcaneus (HP:0008364)1.82115834
123Wormian bones (HP:0002645)1.82098360
124Easy fatigability (HP:0003388)1.82003341
125Shallow orbits (HP:0000586)1.81839823
126Aplasia cutis congenita (HP:0001057)1.81399191
127EMG: neuropathic changes (HP:0003445)1.80638897
128Mesangial abnormality (HP:0001966)1.78270946
129Systemic lupus erythematosus (HP:0002725)1.77308171
130Hip contracture (HP:0003273)1.75620007
131Testicular atrophy (HP:0000029)1.74395303
132Atrophic scars (HP:0001075)1.73112615
133Abnormality of the ischium (HP:0003174)1.72769510
134Aneurysm (HP:0002617)1.72664849
135Sudden cardiac death (HP:0001645)1.70073267
136Facial diplegia (HP:0001349)1.67810775
137Neoplasm of the adrenal gland (HP:0100631)1.66806505
138Nausea (HP:0002018)1.65174815
139Venous insufficiency (HP:0005293)1.64187313
140Limb-girdle muscle atrophy (HP:0003797)1.64066664
141Absent eyebrow (HP:0002223)1.64015211
142Mesomelia (HP:0003027)1.63292517
143Abnormality of the right ventricle (HP:0001707)1.63237249
144Aortic aneurysm (HP:0004942)1.61831577
145Spinal cord lesions (HP:0100561)1.60015764
146Syringomyelia (HP:0003396)1.60015764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.11628494
2KDR4.69193097
3MYLK3.62763071
4TTN3.52825345
5TGFBR22.88972119
6ZAK2.44724886
7OBSCN2.40184452
8EEF2K2.17005403
9LMTK22.13047624
10MAPK151.90972633
11PHKG11.86141579
12PHKG21.86141579
13EPHB21.83105043
14TGFBR11.78992275
15PDK21.72446060
16TRIB31.69780437
17PTK2B1.66542489
18RIPK11.65546223
19DDR21.62528810
20DMPK1.56380301
21BCKDK1.49090270
22AKT31.48385162
23PDK31.45161160
24PDK41.45161160
25MAP3K61.45120652
26MAP2K31.40941667
27PINK11.38508743
28PKN21.34964336
29IRAK31.31838278
30PIK3CA1.28720122
31NEK91.27729735
32MAP3K71.25675540
33PRKG21.25126066
34FGFR41.24106427
35STK241.23705307
36STK38L1.21023297
37INSRR1.19884887
38TESK11.17946349
39ICK1.13419332
40MARK21.06561020
41PTK21.05960800
42GRK11.05886269
43MUSK1.04953015
44PRKD10.97942807
45FES0.92983428
46PRKAA20.90539646
47SMG10.90388012
48MAP3K130.90348495
49ILK0.88566189
50NTRK10.88290537
51MAPK40.87096577
52BMX0.85802063
53MAP3K30.83859076
54PDGFRA0.82467632
55MAPK120.80141912
56NLK0.79527170
57MTOR0.79316039
58PRPF4B0.78046938
59PAK40.77549663
60LATS10.77092872
61TRPM70.73689615
62FER0.73616160
63MAP3K110.72064565
64PRKD30.71086693
65PDPK10.69312244
66ERBB30.68603510
67SGK20.66014044
68STK40.65892228
69CAMK1D0.65024614
70EPHA30.63761837
71PDGFRB0.60483849
72MAP3K10.60337066
73CAMK1G0.59492843
74PLK40.59462133
75SIK30.59218177
76TEC0.58672133
77PRKCH0.58633016
78RPS6KL10.58410641
79RPS6KC10.58410641
80ROCK10.58357629
81MOS0.57439605
82PTK60.57388519
83MAP2K70.56415038
84GRK50.55180039
85PIK3CG0.53883734
86PRKCE0.53861729
87TYRO30.53567502
88KIT0.53192180
89DAPK30.53070605
90RPS6KA60.52867968
91GRK70.51993274
92CAMK40.51322444
93NME10.50726023
94CAMK10.50022287
95CDC42BPA0.48409757
96IRAK40.47567008
97ABL20.47309798
98PRKAA10.46488758
99MET0.45898349
100TSSK60.45570240
101GSK3A0.44731387
102ROCK20.42603123
103FLT30.42156574
104MAPK70.42129844
105ARAF0.41584311
106IRAK10.41237731
107SGK30.39840201
108MAP2K10.38601657
109MAPKAPK30.38531657
110SIK10.38309741
111PRKG10.38242422
112CAMK2G0.38113246
113RET0.37935066
114FGFR30.37070436
115JAK30.36421305
116NEK10.36383495
117CLK10.36192556
118CDK120.36079913
119LATS20.35874099
120YES10.35617074
121CSK0.35153476
122PAK30.34449702
123KSR20.34201852
124MAPK100.32011291
125CAMK2D0.31430172
126EIF2AK20.31184258
127PRKACG0.30591123
128MAPK30.29760196
129PRKD20.29322682
130EPHB10.29300358
131PKN10.28441285
132AKT20.27385288
133JAK10.27038317
134PRKACB0.26099408
135WNK40.25786242
136MAP3K140.25300076
137IRAK20.25262993
138BLK0.21318625
139RPS6KA20.21171888
140PAK20.20000073
141STK380.19462530
142IGF1R0.19064565
143ERN10.18503500

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.55015363
2Dilated cardiomyopathy_Homo sapiens_hsa054143.87710865
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.87299407
4Cardiac muscle contraction_Homo sapiens_hsa042603.17144855
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.71444018
6ECM-receptor interaction_Homo sapiens_hsa045122.56838555
7Propanoate metabolism_Homo sapiens_hsa006402.33523096
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23881610
9Phenylalanine metabolism_Homo sapiens_hsa003602.21521472
10Focal adhesion_Homo sapiens_hsa045102.18966478
11Parkinsons disease_Homo sapiens_hsa050122.16106563
12Viral myocarditis_Homo sapiens_hsa054162.13007402
13Adherens junction_Homo sapiens_hsa045201.83889321
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.82155202
15Oxidative phosphorylation_Homo sapiens_hsa001901.79524998
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.72258470
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65558699
18Huntingtons disease_Homo sapiens_hsa050161.61045354
19Fatty acid degradation_Homo sapiens_hsa000711.54829873
20Notch signaling pathway_Homo sapiens_hsa043301.54476429
21Prion diseases_Homo sapiens_hsa050201.49731631
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46811740
23Alzheimers disease_Homo sapiens_hsa050101.45510726
24Arginine biosynthesis_Homo sapiens_hsa002201.37178999
25Small cell lung cancer_Homo sapiens_hsa052221.33978740
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32105993
27Complement and coagulation cascades_Homo sapiens_hsa046101.31029583
28Protein digestion and absorption_Homo sapiens_hsa049741.25459373
29Histidine metabolism_Homo sapiens_hsa003401.21559655
30Tyrosine metabolism_Homo sapiens_hsa003501.20377743
31Insulin resistance_Homo sapiens_hsa049311.18820556
32cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18469494
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18433902
34Basal cell carcinoma_Homo sapiens_hsa052171.17683426
35Glycerolipid metabolism_Homo sapiens_hsa005611.17309059
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.16881967
37HIF-1 signaling pathway_Homo sapiens_hsa040661.13984985
38Fatty acid metabolism_Homo sapiens_hsa012121.13596988
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11321728
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.06748294
41Arginine and proline metabolism_Homo sapiens_hsa003301.05422871
42Amoebiasis_Homo sapiens_hsa051461.04584163
43Bile secretion_Homo sapiens_hsa049761.03603658
44Toxoplasmosis_Homo sapiens_hsa051451.01715753
45Platelet activation_Homo sapiens_hsa046111.01087847
46Tight junction_Homo sapiens_hsa045300.99975625
47Carbon metabolism_Homo sapiens_hsa012000.99245543
48PPAR signaling pathway_Homo sapiens_hsa033200.99051590
49Pathways in cancer_Homo sapiens_hsa052000.99037965
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97808666
51GnRH signaling pathway_Homo sapiens_hsa049120.96271289
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.95645801
53Sulfur relay system_Homo sapiens_hsa041220.95104099
54Rap1 signaling pathway_Homo sapiens_hsa040150.94493920
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94397794
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.93531546
57Insulin signaling pathway_Homo sapiens_hsa049100.91358133
58Proteoglycans in cancer_Homo sapiens_hsa052050.88967794
59Estrogen signaling pathway_Homo sapiens_hsa049150.86340548
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86185682
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.85919958
62Renin-angiotensin system_Homo sapiens_hsa046140.83347493
63Circadian rhythm_Homo sapiens_hsa047100.80738704
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80121024
65Gastric acid secretion_Homo sapiens_hsa049710.78498550
66Melanoma_Homo sapiens_hsa052180.76192107
67Gap junction_Homo sapiens_hsa045400.75610648
68HTLV-I infection_Homo sapiens_hsa051660.74141010
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73212534
70Glucagon signaling pathway_Homo sapiens_hsa049220.72939875
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.71651205
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71635298
73Ovarian steroidogenesis_Homo sapiens_hsa049130.71593227
74Calcium signaling pathway_Homo sapiens_hsa040200.69241840
75Fat digestion and absorption_Homo sapiens_hsa049750.68456202
76Malaria_Homo sapiens_hsa051440.68161424
77Pyruvate metabolism_Homo sapiens_hsa006200.66318061
78cAMP signaling pathway_Homo sapiens_hsa040240.62888899
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61768075
80Long-term potentiation_Homo sapiens_hsa047200.60131048
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58782846
82Dorso-ventral axis formation_Homo sapiens_hsa043200.58469311
83Circadian entrainment_Homo sapiens_hsa047130.58442637
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55973801
85MAPK signaling pathway_Homo sapiens_hsa040100.55914183
86AMPK signaling pathway_Homo sapiens_hsa041520.55731100
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55578394
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55326868
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55297247
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55291145
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54536966
92Fructose and mannose metabolism_Homo sapiens_hsa000510.53848143
93Renin secretion_Homo sapiens_hsa049240.52845296
94Hippo signaling pathway_Homo sapiens_hsa043900.52584116
95FoxO signaling pathway_Homo sapiens_hsa040680.52271714
96Oxytocin signaling pathway_Homo sapiens_hsa049210.52238146
97Ras signaling pathway_Homo sapiens_hsa040140.50740921
98Tryptophan metabolism_Homo sapiens_hsa003800.50097630
99Hedgehog signaling pathway_Homo sapiens_hsa043400.49840378
100Taste transduction_Homo sapiens_hsa047420.49599115
101Folate biosynthesis_Homo sapiens_hsa007900.49512477
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49462366
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48202927
104Arachidonic acid metabolism_Homo sapiens_hsa005900.47628682
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46459998
106Wnt signaling pathway_Homo sapiens_hsa043100.45603807
107Other glycan degradation_Homo sapiens_hsa005110.45487057
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45467522
109Salmonella infection_Homo sapiens_hsa051320.45392023
110Lysine degradation_Homo sapiens_hsa003100.45211494
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44835892
112Melanogenesis_Homo sapiens_hsa049160.44687763
113Thyroid cancer_Homo sapiens_hsa052160.44410925
114Endometrial cancer_Homo sapiens_hsa052130.42444409
115Pentose phosphate pathway_Homo sapiens_hsa000300.42203702
116Pertussis_Homo sapiens_hsa051330.41475977
117Acute myeloid leukemia_Homo sapiens_hsa052210.41070215
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40629614
119Vitamin digestion and absorption_Homo sapiens_hsa049770.39869034
120Chronic myeloid leukemia_Homo sapiens_hsa052200.38728331
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.38669792
122Biosynthesis of amino acids_Homo sapiens_hsa012300.37166521
123Base excision repair_Homo sapiens_hsa034100.36862192
124MicroRNAs in cancer_Homo sapiens_hsa052060.34468209
125VEGF signaling pathway_Homo sapiens_hsa043700.33901185
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33517477
127Axon guidance_Homo sapiens_hsa043600.32992296
128TNF signaling pathway_Homo sapiens_hsa046680.30741420
129Purine metabolism_Homo sapiens_hsa002300.29161809
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.28832777
131Hematopoietic cell lineage_Homo sapiens_hsa046400.28596048
132Fatty acid biosynthesis_Homo sapiens_hsa000610.27774923
133Leishmaniasis_Homo sapiens_hsa051400.26774650
134Prostate cancer_Homo sapiens_hsa052150.26242930
135Type II diabetes mellitus_Homo sapiens_hsa049300.25751060
136Apoptosis_Homo sapiens_hsa042100.25648626
137Starch and sucrose metabolism_Homo sapiens_hsa005000.24285888
138beta-Alanine metabolism_Homo sapiens_hsa004100.24071915
139Fatty acid elongation_Homo sapiens_hsa000620.22927116
140Renal cell carcinoma_Homo sapiens_hsa052110.22885507

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