HSPA13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.79683819
2COPI coating of Golgi vesicle (GO:0048205)6.79683819
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.51498788
4ER overload response (GO:0006983)4.78405598
5signal peptide processing (GO:0006465)4.72085165
6protein retention in ER lumen (GO:0006621)4.61827272
7protein maturation by protein folding (GO:0022417)4.58632939
8exocrine pancreas development (GO:0031017)4.41999445
9COPII vesicle coating (GO:0048208)4.38469815
10endocrine pancreas development (GO:0031018)4.25510087
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.13882196
12peptide hormone processing (GO:0016486)4.11970055
13nuclear pore organization (GO:0006999)3.99254381
14pyrimidine nucleobase catabolic process (GO:0006208)3.89427202
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.89135761
16nuclear pore complex assembly (GO:0051292)3.83393564
17activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.74589222
18protein targeting to Golgi (GO:0000042)3.71028640
19vesicle coating (GO:0006901)3.69575761
20regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.49558201
21positive regulation of nuclease activity (GO:0032075)3.47751762
22sequestering of metal ion (GO:0051238)3.45045675
23type B pancreatic cell development (GO:0003323)3.44232786
24toxin metabolic process (GO:0009404)3.40079621
25protein localization to Golgi apparatus (GO:0034067)3.38059687
26intra-Golgi vesicle-mediated transport (GO:0006891)3.35957558
27endoplasmic reticulum unfolded protein response (GO:0030968)3.24911905
28establishment of protein localization to Golgi (GO:0072600)3.23349844
29ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.22919944
30nucleobase catabolic process (GO:0046113)3.22062894
31metaphase plate congression (GO:0051310)3.20423509
32cellular response to unfolded protein (GO:0034620)3.15593194
33mitotic sister chromatid cohesion (GO:0007064)3.15224342
34positive regulation of mitochondrial fission (GO:0090141)3.14402895
35retrograde transport, vesicle recycling within Golgi (GO:0000301)3.12687051
36ER-nucleus signaling pathway (GO:0006984)3.12481121
37insulin secretion (GO:0030073)3.10148286
38regulation of nuclease activity (GO:0032069)3.05860888
39cellular response to topologically incorrect protein (GO:0035967)3.03230736
40detection of calcium ion (GO:0005513)3.01931224
41protein N-linked glycosylation via asparagine (GO:0018279)3.01702535
42peptidyl-asparagine modification (GO:0018196)2.97074751
43inner ear receptor cell development (GO:0060119)2.95118449
44postsynaptic membrane organization (GO:0001941)2.92143581
45cullin deneddylation (GO:0010388)2.90651533
46establishment of integrated proviral latency (GO:0075713)2.90353490
47axonal fasciculation (GO:0007413)2.88835788
48pore complex assembly (GO:0046931)2.84649401
49response to endoplasmic reticulum stress (GO:0034976)2.83616898
50positive regulation of insulin secretion (GO:0032024)2.83326015
51negative regulation of DNA recombination (GO:0045910)2.82465420
52mitotic metaphase plate congression (GO:0007080)2.82149440
53glandular epithelial cell development (GO:0002068)2.81126594
54regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.80869241
55protein N-linked glycosylation (GO:0006487)2.79928940
56sister chromatid segregation (GO:0000819)2.78971330
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.76472596
58L-phenylalanine catabolic process (GO:0006559)2.76472596
59regulation of insulin secretion (GO:0050796)2.75072324
60negative regulation of glycogen biosynthetic process (GO:0045719)2.74071705
61ER to Golgi vesicle-mediated transport (GO:0006888)2.73337803
62cellular response to vitamin D (GO:0071305)2.71774120
63glandular epithelial cell differentiation (GO:0002067)2.71127556
64macroautophagy (GO:0016236)2.70613855
65regulation of type B pancreatic cell apoptotic process (GO:2000674)2.70310870
66DNA double-strand break processing (GO:0000729)2.69989914
67presynaptic membrane assembly (GO:0097105)2.68370832
68L-serine transport (GO:0015825)2.66689142
69cellular response to ATP (GO:0071318)2.64797465
70double-strand break repair via nonhomologous end joining (GO:0006303)2.63839003
71non-recombinational repair (GO:0000726)2.63839003
72establishment of chromosome localization (GO:0051303)2.63319005
73negative regulation of glycogen metabolic process (GO:0070874)2.61679444
74negative regulation of neurotransmitter secretion (GO:0046929)2.61346666
75positive regulation of glycolytic process (GO:0045821)2.60594429
76regulation of Golgi to plasma membrane protein transport (GO:0042996)2.59457747
77dopamine biosynthetic process (GO:0042416)2.59037422
78protein deneddylation (GO:0000338)2.57085832
79chondrocyte development (GO:0002063)2.57078565
80kinetochore organization (GO:0051383)2.56198447
81cerebellar Purkinje cell layer development (GO:0021680)2.56022149
82regulation of beta-amyloid formation (GO:1902003)2.55552386
83parental behavior (GO:0060746)2.55046505
84maternal behavior (GO:0042711)2.54972388
85calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.54493949
86regulation of peptide hormone secretion (GO:0090276)2.54270673
87response to unfolded protein (GO:0006986)2.53618312
88regulation of coenzyme metabolic process (GO:0051196)2.53477452
89regulation of cofactor metabolic process (GO:0051193)2.53477452
90regulation of centriole replication (GO:0046599)2.52602804
91mitotic sister chromatid segregation (GO:0000070)2.52500333
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.52246679
93regulation of peptide secretion (GO:0002791)2.50986902
944-hydroxyproline metabolic process (GO:0019471)2.48816210
95regulation of mitotic spindle organization (GO:0060236)2.47729913
96cellular response to glucagon stimulus (GO:0071377)2.47600274
97intestinal cholesterol absorption (GO:0030299)2.47471771
98DNA ligation (GO:0006266)2.47391328
99response to topologically incorrect protein (GO:0035966)2.46609159
100limb bud formation (GO:0060174)2.46321837
101spindle checkpoint (GO:0031577)2.45603827
102regulation of DNA endoreduplication (GO:0032875)2.44307474
103glycosphingolipid biosynthetic process (GO:0006688)2.43773964
104tRNA aminoacylation for protein translation (GO:0006418)2.43747323
105negative regulation of neurotransmitter transport (GO:0051589)2.43170554
106paraxial mesoderm development (GO:0048339)2.42508934
107positive regulation of peptide hormone secretion (GO:0090277)2.41782045
108endoplasmic reticulum organization (GO:0007029)2.41218470
109mitotic spindle organization (GO:0007052)2.40619257
110spermatid nucleus differentiation (GO:0007289)2.39993194
111positive regulation of peptide secretion (GO:0002793)2.39561540
112histone H2A acetylation (GO:0043968)2.39294301
113amino acid activation (GO:0043038)2.39248447
114tRNA aminoacylation (GO:0043039)2.39248447
115intraciliary transport (GO:0042073)2.38900958
116prostate gland growth (GO:0060736)2.38259669
117regulation of amyloid precursor protein catabolic process (GO:1902991)2.38125495
118peptide secretion (GO:0002790)2.37320581
119mitotic spindle checkpoint (GO:0071174)2.37214727
120protein localization to kinetochore (GO:0034501)2.36756499
121kinetochore assembly (GO:0051382)2.36287868
122catechol-containing compound biosynthetic process (GO:0009713)2.35999318
123catecholamine biosynthetic process (GO:0042423)2.35999318
124induction of positive chemotaxis (GO:0050930)2.35413054
125regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.34926562
126peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.34766444
127lactate metabolic process (GO:0006089)2.34518167
128establishment of mitochondrion localization (GO:0051654)2.33830531
129neuron recognition (GO:0008038)2.33811269
130neural tube formation (GO:0001841)2.33046281
131Golgi organization (GO:0007030)2.32741299
132magnesium ion transport (GO:0015693)2.32641983
133establishment of viral latency (GO:0019043)2.32573885
134nonmotile primary cilium assembly (GO:0035058)2.32442392
135regulation of cAMP-dependent protein kinase activity (GO:2000479)2.32309327
136ribonucleoprotein complex disassembly (GO:0032988)2.32197901
137righting reflex (GO:0060013)2.32154620
138synapse assembly (GO:0007416)2.32137723
139peptide hormone secretion (GO:0030072)2.32094489
140resolution of meiotic recombination intermediates (GO:0000712)2.29900759
141regulation of sister chromatid cohesion (GO:0007063)2.29287098
142olfactory bulb development (GO:0021772)2.29048410
143regulation of acyl-CoA biosynthetic process (GO:0050812)2.28420134
144nucleotide transmembrane transport (GO:1901679)2.28035974
145protein localization to synapse (GO:0035418)2.28022088
146regulation of chromosome segregation (GO:0051983)2.28011370
147regulation of hormone secretion (GO:0046883)2.27439871
148cytoskeleton-dependent intracellular transport (GO:0030705)2.26760274
149Golgi vesicle transport (GO:0048193)2.26745051
150neuron cell-cell adhesion (GO:0007158)2.26372881
151ventricular cardiac muscle cell development (GO:0055015)2.25644806
152microtubule depolymerization (GO:0007019)2.23724062
153nitric oxide mediated signal transduction (GO:0007263)2.23703795
154gastrulation with mouth forming second (GO:0001702)2.23151223
155response to follicle-stimulating hormone (GO:0032354)2.22740181
156UDP-N-acetylglucosamine metabolic process (GO:0006047)2.22727893
157positive regulation of hormone biosynthetic process (GO:0046886)2.22413086
158attachment of spindle microtubules to kinetochore (GO:0008608)2.22285556
159erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.20959885
160L-phenylalanine metabolic process (GO:0006558)2.20959885
161dendritic spine morphogenesis (GO:0060997)2.20735785
162negative regulation of JUN kinase activity (GO:0043508)2.20564504
163serotonin metabolic process (GO:0042428)2.19901839
164negative regulation of meiosis (GO:0045835)2.19476564
165regulation of synaptic vesicle exocytosis (GO:2000300)2.18978241
166insulin-like growth factor receptor signaling pathway (GO:0048009)2.18602404
167cell adhesion mediated by integrin (GO:0033627)2.18545373
168presynaptic membrane organization (GO:0097090)2.18519992
169ribosome assembly (GO:0042255)2.18103737
170embryonic foregut morphogenesis (GO:0048617)2.17971172
171pancreas development (GO:0031016)2.17694539
172microtubule-based transport (GO:0010970)2.16825062
173protein localization to chromosome, centromeric region (GO:0071459)2.16458503
174asymmetric protein localization (GO:0008105)2.14942194
175neurotransmitter-gated ion channel clustering (GO:0072578)2.14411064
176CENP-A containing nucleosome assembly (GO:0034080)2.13220234
177positive regulation of synapse assembly (GO:0051965)2.12063894
178cholesterol biosynthetic process (GO:0006695)2.11682887
179mitotic spindle assembly checkpoint (GO:0007094)2.11240047
180DNA damage response, detection of DNA damage (GO:0042769)2.11198661
181membrane disassembly (GO:0030397)2.08672265
182nuclear envelope disassembly (GO:0051081)2.08672265
183negative regulation of oligodendrocyte differentiation (GO:0048715)2.08400130
184peptidyl-cysteine modification (GO:0018198)2.08279663
185cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.08114446
186positive regulation of male gonad development (GO:2000020)2.07713768
187serine transport (GO:0032329)2.07711363
188negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.07289046
189negative regulation of mitotic sister chromatid segregation (GO:0033048)2.07289046
190negative regulation of sister chromatid segregation (GO:0033046)2.07289046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.99996215
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.21074273
3GBX2_23144817_ChIP-Seq_PC3_Human3.13357245
4IGF1R_20145208_ChIP-Seq_DFB_Human2.77864464
5EZH2_22144423_ChIP-Seq_EOC_Human2.69553331
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60167364
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43474099
8* FOXM1_23109430_ChIP-Seq_U2OS_Human2.39843207
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35054342
10TAF15_26573619_Chip-Seq_HEK293_Human2.32149212
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30610087
12ELK1_19687146_ChIP-ChIP_HELA_Human2.27632954
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.22688276
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21662090
15EWS_26573619_Chip-Seq_HEK293_Human2.18765088
16PIAS1_25552417_ChIP-Seq_VCAP_Human2.08760530
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07470260
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06946095
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06346517
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.04800707
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01240277
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00094067
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99285701
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98818684
25ZNF274_21170338_ChIP-Seq_K562_Hela1.97497257
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95040265
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.89331399
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86445486
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85878763
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80957728
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.79122177
32* P300_19829295_ChIP-Seq_ESCs_Human1.75879636
33GATA1_22025678_ChIP-Seq_K562_Human1.75751262
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75128728
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74760578
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74093367
37E2F7_22180533_ChIP-Seq_HELA_Human1.71879478
38SMAD4_21799915_ChIP-Seq_A2780_Human1.71259531
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71044474
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70742443
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.69614716
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68260535
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.68107013
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.68107013
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67868825
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66465941
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66344613
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.64181171
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.62260095
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62055178
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61039333
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59471553
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59060704
54ER_23166858_ChIP-Seq_MCF-7_Human1.58533717
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58384080
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.56672299
57AR_21909140_ChIP-Seq_LNCAP_Human1.56596123
58* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53773790
59AR_21572438_ChIP-Seq_LNCaP_Human1.50761896
60FUS_26573619_Chip-Seq_HEK293_Human1.50286763
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50061751
62* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47481127
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46334738
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.45850947
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44238853
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40858435
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39647273
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39647273
69VDR_22108803_ChIP-Seq_LS180_Human1.39250963
70STAT3_23295773_ChIP-Seq_U87_Human1.39026093
71* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38443502
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35462166
73CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35088754
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34956234
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34666823
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33753653
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.33747975
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33150042
79BCAT_22108803_ChIP-Seq_LS180_Human1.32951580
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32593748
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32137448
82REST_21632747_ChIP-Seq_MESCs_Mouse1.31995765
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.30683814
84TP53_18474530_ChIP-ChIP_U2OS_Human1.26595649
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.25972971
86* SOX9_26525672_Chip-Seq_HEART_Mouse1.25664274
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25659967
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24247191
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22676058
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.21646346
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21264856
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21200336
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.20989508
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20515335
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19390753
96RUNX2_22187159_ChIP-Seq_PCA_Human1.18486994
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18442118
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18136607
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18014207
100RNF2_27304074_Chip-Seq_NSC_Mouse1.17922124
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17704297
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17486427
103AR_25329375_ChIP-Seq_VCAP_Human1.16536209
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14574898
105TCF4_23295773_ChIP-Seq_U87_Human1.14495191
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14196054
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.14172366
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.13596751
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13573023
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.13489946
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12386881
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.11950578
113MYC_18940864_ChIP-ChIP_HL60_Human1.11474385
114REST_19997604_ChIP-ChIP_NEURONS_Mouse1.10900813
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09120328
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09028058
117SOX2_16153702_ChIP-ChIP_HESCs_Human1.08392182
118NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08212152
119CLOCK_20551151_ChIP-Seq_293T_Human1.08176214
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07767014
121CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07680087
122RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07480476
123DCP1A_22483619_ChIP-Seq_HELA_Human1.07284607
124CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07197689
125PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04723387
126LXR_22158963_ChIP-Seq_LIVER_Mouse1.04385206
127FLI1_21867929_ChIP-Seq_TH2_Mouse1.03649800
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03524609
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03374031
130* VDR_23849224_ChIP-Seq_CD4+_Human1.03290834
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02704953
132* KDM2B_26808549_Chip-Seq_REH_Human1.02486743
133P53_22387025_ChIP-Seq_ESCs_Mouse1.01470471
134LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00774879
135KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99895840
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99667547
137AHR_22903824_ChIP-Seq_MCF-7_Human0.99184097
138SOX17_20123909_ChIP-Seq_XEN_Mouse0.98212624
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.97973910
140YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97936063
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.97931550
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97406381
143CBP_20019798_ChIP-Seq_JUKART_Human0.96906301
144IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96906301
145JUN_21703547_ChIP-Seq_K562_Human0.96831393
146TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96526399
147ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96432199
148SOX2_20726797_ChIP-Seq_SW620_Human0.96276413
149BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96268594
150TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95754466
151FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95443119
152EZH2_27294783_Chip-Seq_NPCs_Mouse0.95220412
153NANOG_16153702_ChIP-ChIP_HESCs_Human0.94181773
154BRD4_25478319_ChIP-Seq_HGPS_Human0.93658229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.75843008
2MP0009780_abnormal_chondrocyte_physiolo3.65951695
3MP0000013_abnormal_adipose_tissue3.07415711
4MP0002837_dystrophic_cardiac_calcinosis3.04444182
5MP0002877_abnormal_melanocyte_morpholog2.84206460
6MP0008438_abnormal_cutaneous_collagen2.74926804
7MP0010386_abnormal_urinary_bladder2.70814833
8MP0002909_abnormal_adrenal_gland2.62692826
9MP0002693_abnormal_pancreas_physiology2.51701491
10MP0005379_endocrine/exocrine_gland_phen2.51113809
11MP0003122_maternal_imprinting2.49061007
12MP0001529_abnormal_vocalization2.48957684
13MP0005645_abnormal_hypothalamus_physiol2.43423118
14MP0001944_abnormal_pancreas_morphology2.41604117
15MP0003283_abnormal_digestive_organ2.33302406
16MP0005646_abnormal_pituitary_gland2.25010955
17MP0004043_abnormal_pH_regulation2.21197626
18MP0003890_abnormal_embryonic-extraembry2.11332870
19MP0005220_abnormal_exocrine_pancreas2.11091898
20MP0002102_abnormal_ear_morphology2.08584719
21MP0005503_abnormal_tendon_morphology2.07115340
22MP0002139_abnormal_hepatobiliary_system2.07048146
23MP0003121_genomic_imprinting2.01500220
24MP0003868_abnormal_feces_composition1.99201701
25MP0005365_abnormal_bile_salt1.96361097
26MP0003183_abnormal_peptide_metabolism1.92198496
27MP0001984_abnormal_olfaction1.87449675
28MP0002896_abnormal_bone_mineralization1.75146157
29MP0005623_abnormal_meninges_morphology1.75000584
30MP0003221_abnormal_cardiomyocyte_apopto1.73853675
31MP0006054_spinal_hemorrhage1.62286592
32MP0004270_analgesia1.62159287
33MP0002078_abnormal_glucose_homeostasis1.61247919
34MP0009697_abnormal_copulation1.58867710
35MP0000003_abnormal_adipose_tissue1.58326106
36MP0003880_abnormal_central_pattern1.55087776
37MP0003937_abnormal_limbs/digits/tail_de1.53681983
38MP0002751_abnormal_autonomic_nervous1.51988316
39MP0008877_abnormal_DNA_methylation1.49871207
40MP0003252_abnormal_bile_duct1.48064156
41MP0008058_abnormal_DNA_repair1.45742224
42MP0003959_abnormal_lean_body1.45699506
43MP0000372_irregular_coat_pigmentation1.45323427
44MP0001666_abnormal_nutrient_absorption1.43437491
45MP0005535_abnormal_body_temperature1.42318829
46MP0009046_muscle_twitch1.42130574
47MP0006276_abnormal_autonomic_nervous1.40606515
48MP0004272_abnormal_basement_membrane1.38404270
49MP0010352_gastrointestinal_tract_polyps1.37755681
50MP0000631_abnormal_neuroendocrine_gland1.36435162
51MP0001299_abnormal_eye_distance/1.36125100
52MP0003635_abnormal_synaptic_transmissio1.35986252
53MP0002876_abnormal_thyroid_physiology1.35491984
54MP0000537_abnormal_urethra_morphology1.35015791
55MP0002938_white_spotting1.31382488
56MP0005085_abnormal_gallbladder_physiolo1.31183368
57MP0004811_abnormal_neuron_physiology1.30328670
58MP0002638_abnormal_pupillary_reflex1.29451096
59MP0008932_abnormal_embryonic_tissue1.29227510
60MP0002233_abnormal_nose_morphology1.28408337
61MP0003567_abnormal_fetal_cardiomyocyte1.27664409
62MP0009384_cardiac_valve_regurgitation1.27400620
63MP0003755_abnormal_palate_morphology1.25841223
64MP0006072_abnormal_retinal_apoptosis1.23864906
65MP0005253_abnormal_eye_physiology1.23757517
66MP0002697_abnormal_eye_size1.23213663
67MP0003787_abnormal_imprinting1.22671014
68MP0003111_abnormal_nucleus_morphology1.22506534
69MP0001188_hyperpigmentation1.22042292
70MP0005275_abnormal_skin_tensile1.21613132
71MP0000647_abnormal_sebaceous_gland1.20203266
72MP0001293_anophthalmia1.19980259
73MP0000678_abnormal_parathyroid_gland1.19324938
74MP0005408_hypopigmentation1.18672675
75MP0008057_abnormal_DNA_replication1.18581245
76MP0002063_abnormal_learning/memory/cond1.18395116
77MP0010094_abnormal_chromosome_stability1.18001696
78MP0005248_abnormal_Harderian_gland1.17341868
79MP0002295_abnormal_pulmonary_circulatio1.13850555
80MP0003077_abnormal_cell_cycle1.12147792
81MP0002734_abnormal_mechanical_nocicepti1.10063301
82MP0002084_abnormal_developmental_patter1.09939660
83MP0004957_abnormal_blastocyst_morpholog1.09432538
84MP0003385_abnormal_body_wall1.08565621
85MP0002572_abnormal_emotion/affect_behav1.08364950
86MP0004197_abnormal_fetal_growth/weight/1.08260696
87MP0001501_abnormal_sleep_pattern1.06947879
88MP0003693_abnormal_embryo_hatching1.06791632
89MP0009745_abnormal_behavioral_response1.06601041
90MP0005058_abnormal_lysosome_morphology1.06309619
91MP0003861_abnormal_nervous_system1.05590461
92MP0005367_renal/urinary_system_phenotyp1.05147155
93MP0000516_abnormal_urinary_system1.05147155
94MP0005391_vision/eye_phenotype1.04598617
95MP0002928_abnormal_bile_duct1.03264453
96MP0000538_abnormal_urinary_bladder1.02699177
97MP0005360_urolithiasis1.02681202
98MP0000569_abnormal_digit_pigmentation1.01904343
99MP0008007_abnormal_cellular_replicative1.01866925
100MP0001765_abnormal_ion_homeostasis1.01297608
101MP0002108_abnormal_muscle_morphology1.01290161
102MP0005257_abnormal_intraocular_pressure1.00177673
103MP0005394_taste/olfaction_phenotype0.99968896
104MP0005499_abnormal_olfactory_system0.99968896
105MP0005187_abnormal_penis_morphology0.99488480
106MP0001286_abnormal_eye_development0.98916903
107MP0002009_preneoplasia0.98588529
108MP0005083_abnormal_biliary_tract0.97956181
109MP0003935_abnormal_craniofacial_develop0.97880340
110MP0003953_abnormal_hormone_level0.97831767
111MP0005423_abnormal_somatic_nervous0.97156182
112MP0000462_abnormal_digestive_system0.96082078
113MP0001177_atelectasis0.94802551
114MP0002092_abnormal_eye_morphology0.94611287
115MP0000681_abnormal_thyroid_gland0.94389285
116MP0000778_abnormal_nervous_system0.94263076
117MP0003136_yellow_coat_color0.94168549
118MP0008995_early_reproductive_senescence0.93942927
119MP0009703_decreased_birth_body0.92090997
120MP0000639_abnormal_adrenal_gland0.91694564
121MP0005084_abnormal_gallbladder_morpholo0.91573935
122MP0002882_abnormal_neuron_morphology0.91072980
123MP0002733_abnormal_thermal_nociception0.89075355
124MP0001502_abnormal_circadian_rhythm0.88159072
125MP0002152_abnormal_brain_morphology0.87961098
126MP0000230_abnormal_systemic_arterial0.87833634
127MP0002064_seizures0.86954017
128MP0004859_abnormal_synaptic_plasticity0.86934234
129MP0002081_perinatal_lethality0.86658454
130MP0003115_abnormal_respiratory_system0.86017090
131MP0002557_abnormal_social/conspecific_i0.85989811
132MP0000955_abnormal_spinal_cord0.84826594
133MP0002177_abnormal_outer_ear0.84335120
134MP0002736_abnormal_nociception_after0.83820819
135MP0003786_premature_aging0.83526064
136MP0003941_abnormal_skin_development0.83379964
137MP0002085_abnormal_embryonic_tissue0.83297989
138MP0003942_abnormal_urinary_system0.83249297
139MP0000613_abnormal_salivary_gland0.81725343
140MP0004264_abnormal_extraembryonic_tissu0.81674589
141MP0003119_abnormal_digestive_system0.81070067
142MP0002090_abnormal_vision0.80724458
143MP0000163_abnormal_cartilage_morphology0.80463410
144MP0008789_abnormal_olfactory_epithelium0.80062347
145MP0005448_abnormal_energy_balance0.80031647
146MP0002282_abnormal_trachea_morphology0.79931581
147MP0005171_absent_coat_pigmentation0.79606911
148MP0003634_abnormal_glial_cell0.79589064
149MP0002184_abnormal_innervation0.78981580
150MP0001697_abnormal_embryo_size0.78847619
151MP0003329_amyloid_beta_deposits0.78264784
152MP0002272_abnormal_nervous_system0.78246012
153MP0003172_abnormal_lysosome_physiology0.76807187
154MP0001440_abnormal_grooming_behavior0.76683972
155MP0003300_gastrointestinal_ulcer0.74788901
156MP0001664_abnormal_digestion0.74456711
157MP0008875_abnormal_xenobiotic_pharmacok0.74346639
158MP0004924_abnormal_behavior0.73570924
159MP0005386_behavior/neurological_phenoty0.73570924
160MP0000920_abnormal_myelination0.73446987
161MP0002234_abnormal_pharynx_morphology0.72633913
162MP0005636_abnormal_mineral_homeostasis0.71692893
163MP0002168_other_aberrant_phenotype0.71473164
164MP0002118_abnormal_lipid_homeostasis0.70634120
165MP0002163_abnormal_gland_morphology0.70234700
166MP0003045_fibrosis0.69690931
167MP0002069_abnormal_eating/drinking_beha0.69242244

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.91350757
2Hypoglycemic seizures (HP:0002173)4.88344167
3Symptomatic seizures (HP:0011145)4.87572713
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.74905259
5Cortical dysplasia (HP:0002539)4.63467202
6Hypoglycemic coma (HP:0001325)3.99605986
7Conjugated hyperbilirubinemia (HP:0002908)3.72755151
8Abnormality of the intrinsic pathway (HP:0010989)3.71426370
9Agitation (HP:0000713)3.66579493
10Hyperglycemia (HP:0003074)3.51965770
11Abnormality of the pancreatic islet cells (HP:0006476)3.40705360
12Abnormality of endocrine pancreas physiology (HP:0012093)3.40705360
13Abnormality of calcium-phosphate metabolism (HP:0100530)3.33986994
14Pancreatic islet-cell hyperplasia (HP:0004510)3.28628010
15Insulin-resistant diabetes mellitus (HP:0000831)3.26937581
16Abnormality of the common coagulation pathway (HP:0010990)3.23849836
17Ketoacidosis (HP:0001993)3.12345938
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.04072234
19Hypothermia (HP:0002045)3.02389898
20Papillary thyroid carcinoma (HP:0002895)2.89870856
21Volvulus (HP:0002580)2.88034804
22EEG with generalized epileptiform discharges (HP:0011198)2.81821294
23Abnormal pancreas size (HP:0012094)2.81461559
24Epileptiform EEG discharges (HP:0011182)2.78189844
25Hypsarrhythmia (HP:0002521)2.75159517
26Urinary glycosaminoglycan excretion (HP:0003541)2.74256879
27Mucopolysacchariduria (HP:0008155)2.74256879
28Abnormality of the corticospinal tract (HP:0002492)2.74027398
29Shoulder girdle muscle weakness (HP:0003547)2.71270124
30Abnormal lung lobation (HP:0002101)2.64455516
31Papilledema (HP:0001085)2.63544868
32Thyroid carcinoma (HP:0002890)2.60558947
33Dysostosis multiplex (HP:0000943)2.59188009
34Intestinal atresia (HP:0011100)2.52742136
35Abnormality of the hip-girdle musculature (HP:0001445)2.52583671
36Abnormality of the musculature of the pelvis (HP:0001469)2.52583671
37Skin nodule (HP:0200036)2.47560390
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.44654947
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.44654947
40Abnormality of polysaccharide metabolism (HP:0011012)2.44654947
41Pheochromocytoma (HP:0002666)2.44043837
42Hepatoblastoma (HP:0002884)2.43199788
43Macroorchidism (HP:0000053)2.41138498
44Cerebral inclusion bodies (HP:0100314)2.40495375
45Intrahepatic cholestasis (HP:0001406)2.39175864
46Blue irides (HP:0000635)2.37801064
47Neurofibrillary tangles (HP:0002185)2.30598537
48Amyotrophic lateral sclerosis (HP:0007354)2.29423948
49Abnormality of the lower motor neuron (HP:0002366)2.27538197
50Prolonged partial thromboplastin time (HP:0003645)2.24447868
51Congenital glaucoma (HP:0001087)2.24415597
52Atrophy/Degeneration involving motor neurons (HP:0007373)2.24389219
53Osteomalacia (HP:0002749)2.21537521
54Type II lissencephaly (HP:0007260)2.20818771
55Ependymoma (HP:0002888)2.18597051
56Neuroendocrine neoplasm (HP:0100634)2.18383658
57Astrocytoma (HP:0009592)2.16020928
58Abnormality of the astrocytes (HP:0100707)2.16020928
59Hypokalemia (HP:0002900)2.10900964
60Impaired vibration sensation in the lower limbs (HP:0002166)2.09756416
61Spastic diplegia (HP:0001264)2.07558019
62Protuberant abdomen (HP:0001538)2.07360916
63Retinal atrophy (HP:0001105)2.07054254
64Buphthalmos (HP:0000557)2.06766032
65Urinary urgency (HP:0000012)2.05047896
66Large for gestational age (HP:0001520)2.02453355
67Fat malabsorption (HP:0002630)2.01229136
68Gait imbalance (HP:0002141)1.99948266
69Generalized aminoaciduria (HP:0002909)1.99625887
70Late onset (HP:0003584)1.99368273
71Atonic seizures (HP:0010819)1.97655835
72Ketosis (HP:0001946)1.95397253
73Postural tremor (HP:0002174)1.95347601
74Limb-girdle muscle weakness (HP:0003325)1.93650777
75Hypophosphatemia (HP:0002148)1.93484921
76Insidious onset (HP:0003587)1.92014363
77Termporal pattern (HP:0011008)1.92014363
78Increased nuchal translucency (HP:0010880)1.91501099
79Upper limb muscle weakness (HP:0003484)1.91213569
80Congenital primary aphakia (HP:0007707)1.90188515
81Glioma (HP:0009733)1.90113416
82Abnormality of the metopic suture (HP:0005556)1.89288059
83Thoracolumbar scoliosis (HP:0002944)1.89114025
84Decreased circulating renin level (HP:0003351)1.88824099
85Neoplasm of the peripheral nervous system (HP:0100007)1.88553637
86Restlessness (HP:0000711)1.87923447
87Visual hallucinations (HP:0002367)1.86736536
88Abnormality of dentin (HP:0010299)1.86591509
89Postnatal microcephaly (HP:0005484)1.86147530
90Abnormality of the anterior horn cell (HP:0006802)1.85212831
91Degeneration of anterior horn cells (HP:0002398)1.85212831
92Embryonal renal neoplasm (HP:0011794)1.83964789
93Hyperphosphaturia (HP:0003109)1.83640306
94Lissencephaly (HP:0001339)1.81081794
95Abnormality of the labia minora (HP:0012880)1.79539854
96Colon cancer (HP:0003003)1.79218770
97Infantile muscular hypotonia (HP:0008947)1.78794806
98Abdominal distention (HP:0003270)1.78505541
99Spastic gait (HP:0002064)1.78463493
100Medulloblastoma (HP:0002885)1.78403000
101Genital tract atresia (HP:0001827)1.77581436
102Medial flaring of the eyebrow (HP:0010747)1.77444503
103Complement deficiency (HP:0004431)1.76408370
104Arterial tortuosity (HP:0005116)1.76144608
105Abnormal auditory evoked potentials (HP:0006958)1.74700514
106Nephroblastoma (Wilms tumor) (HP:0002667)1.74496345
107Spastic tetraplegia (HP:0002510)1.74042860
108Absent eyebrow (HP:0002223)1.73494462
109Limb dystonia (HP:0002451)1.73203582
110Enlarged epiphyses (HP:0010580)1.73039135
111Vascular tortuosity (HP:0004948)1.72764344
112Large earlobe (HP:0009748)1.72084243
113Nephrogenic diabetes insipidus (HP:0009806)1.71917833
114Neoplasm of the thyroid gland (HP:0100031)1.71149383
115Hypophosphatemic rickets (HP:0004912)1.71001295
116Resting tremor (HP:0002322)1.70826820
117Drooling (HP:0002307)1.70604670
118Excessive salivation (HP:0003781)1.70604670
119Failure to thrive in infancy (HP:0001531)1.70402516
120Abnormality of potassium homeostasis (HP:0011042)1.70235706
121Vaginal atresia (HP:0000148)1.70163732
122Abnormal glycosylation (HP:0012345)1.70048527
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70048527
124Abnormal protein N-linked glycosylation (HP:0012347)1.70048527
125Abnormal protein glycosylation (HP:0012346)1.70048527
126Hyperparathyroidism (HP:0000843)1.69333726
127Pelvic girdle muscle weakness (HP:0003749)1.69285097
128Bifid tongue (HP:0010297)1.68974284
129Lower limb muscle weakness (HP:0007340)1.67484570
130Paraplegia (HP:0010550)1.65855413
131Postaxial hand polydactyly (HP:0001162)1.65345581
132Epiphyseal dysplasia (HP:0002656)1.63362230
133Premature rupture of membranes (HP:0001788)1.63300212
134Muscular hypotonia of the trunk (HP:0008936)1.63274576
135Anxiety (HP:0000739)1.63200958
136Hand muscle atrophy (HP:0009130)1.62131561
137Absence seizures (HP:0002121)1.61529722
138Short tibia (HP:0005736)1.61417215
139Prominent metopic ridge (HP:0005487)1.60629357
140Thin bony cortex (HP:0002753)1.60455138
141Truncal ataxia (HP:0002078)1.60206185
142Spastic paraplegia (HP:0001258)1.59971943
143Generalized hypopigmentation of hair (HP:0011358)1.59588294
144Aqueductal stenosis (HP:0002410)1.59558024
145Micropenis (HP:0000054)1.59498971
146Broad foot (HP:0001769)1.58176256
147Oligomenorrhea (HP:0000876)1.57327867
148Hyperventilation (HP:0002883)1.56995688
149Gastrointestinal atresia (HP:0002589)1.56557001
150Labial hypoplasia (HP:0000066)1.56496981
151Hypoplasia of the fovea (HP:0007750)1.56227638
152Aplasia/Hypoplasia of the fovea (HP:0008060)1.56227638
153Insulin resistance (HP:0000855)1.56139916
154Exostoses (HP:0100777)1.55993211
155Aplasia/Hypoplasia of the brainstem (HP:0007362)1.55620614
156Hypoplasia of the brainstem (HP:0002365)1.55620614
157Retinal dysplasia (HP:0007973)1.55571881
158Delayed gross motor development (HP:0002194)1.55509925
159Meckel diverticulum (HP:0002245)1.55383123
160Rhabdomyosarcoma (HP:0002859)1.54785067
161Chronic hepatic failure (HP:0100626)1.54728576
162Narrow forehead (HP:0000341)1.53924998
163Specific learning disability (HP:0001328)1.53831510
164Disproportionate short-trunk short stature (HP:0003521)1.53571427
165Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.53381548
166Degeneration of the lateral corticospinal tracts (HP:0002314)1.53381548
167Ovarian neoplasm (HP:0100615)1.52998365
168Hypoventilation (HP:0002791)1.52709189
169Patchy hypopigmentation of hair (HP:0011365)1.52256586
170Bronchomalacia (HP:0002780)1.51826460
171Rimmed vacuoles (HP:0003805)1.51759151
172Follicular hyperkeratosis (HP:0007502)1.51185642
173Enlarged kidneys (HP:0000105)1.51064550
174Overlapping toe (HP:0001845)1.50543308
175True hermaphroditism (HP:0010459)1.48967357
176Open mouth (HP:0000194)1.48673681
177Abnormality of the ileum (HP:0001549)1.48559960
178Hypoplastic pelvis (HP:0008839)1.47806177
179Vertebral arch anomaly (HP:0008438)1.47190486
180Freckling (HP:0001480)1.46662561
181Tetraparesis (HP:0002273)1.46243800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.40510928
2FRK4.15669837
3TRIM283.59478103
4NTRK32.89433711
5TAOK32.88366968
6SRPK12.68360165
7PASK2.65792221
8TSSK62.39184343
9PBK2.33511439
10SCYL22.21774087
11MAP3K22.09577136
12BRD42.09367193
13MAPK152.09227283
14NEK11.99100726
15NTRK11.97433704
16BUB11.95688386
17CASK1.93453324
18EIF2AK11.91198012
19WEE11.84047500
20PLK31.81020715
21PDGFRA1.77489479
22STK38L1.77015483
23UHMK11.76861954
24MKNK11.74613473
25MAP3K41.74004838
26HIPK21.67629507
27MKNK21.64932263
28FGFR21.63299725
29EPHA31.61440245
30TTK1.56342243
31PNCK1.54555204
32CCNB11.53959984
33SIK31.51053688
34AKT31.50696728
35CAMKK21.49281542
36WNK41.48241431
37MARK11.46780176
38LATS11.45543100
39PAK31.44459079
40FER1.44245321
41MET1.42007210
42WNK31.39941382
43CSNK1G11.35534347
44MAP2K71.31112574
45BMPR1B1.30098371
46PLK41.29294118
47MAP4K21.27242245
48BCR1.26958426
49DDR21.23777620
50PRKCE1.21048767
51PLK21.16656370
52ERBB31.14387473
53MAP2K41.12271141
54RET1.08461109
55EPHA41.07290468
56PRKD31.07067679
57GRK71.05071904
58PIK3CG1.03872780
59RPS6KA41.02232823
60PAK61.01307400
61BRSK20.92347351
62CDC70.91918035
63CAMK2B0.91858053
64DYRK30.91548626
65PLK10.90737604
66ERBB40.90425877
67EIF2AK30.90168626
68ERN10.90080346
69MAP3K120.88508359
70CAMK1G0.88320379
71STK390.88138902
72MINK10.86318663
73YES10.85775843
74CAMK2A0.83790368
75STK30.83612155
76FGR0.83400302
77WNK10.83110141
78PTK20.82991718
79CDC42BPA0.81268034
80PIK3CA0.81033305
81CAMK2D0.80728184
82CDK180.78571847
83PRKCH0.77998098
84MST1R0.77400520
85KSR10.77297564
86MAP3K10.75376050
87LATS20.75373599
88CDK50.74641124
89CAMK1D0.74342862
90DYRK20.74208492
91PDGFRB0.72782898
92NUAK10.71495898
93CDK140.70661059
94BCKDK0.67029176
95FGFR10.66683543
96SIK10.66652556
97CSNK1G20.66170051
98ACVR1B0.66006037
99EIF2AK20.65566850
100MAPK130.65158403
101CDK150.64046462
102BRSK10.62634200
103SGK4940.62629209
104SGK2230.62629209
105GRK50.62380299
106BMPR20.61644792
107ADRBK10.61435358
108IGF1R0.60811748
109TNIK0.58777144
110CLK10.58711246
111NTRK20.58257162
112OXSR10.57523987
113GSK3A0.57003184
114EPHB20.56927903
115CDK11A0.56057938
116PRKCG0.55313848
117IRAK20.54024737
118ATM0.52770501
119IRAK10.51363593
120PRKG10.50441700
121ZAK0.49047063
122NEK60.48555693
123SGK20.48546809
124ADRBK20.48166228
125BRAF0.47682724
126RPS6KA20.47133289
127PTK60.47080178
128PINK10.46951278
129SGK10.45952448
130IRAK30.45920225
131FLT30.44569442
132MAP3K60.44197466
133CSNK1G30.43165013
134JAK10.42348475
135DYRK1A0.41591613
136NEK20.41370211
137LIMK10.40947913
138RPS6KB10.40735531
139STK160.40379351
140MYLK0.39975645
141PRKACA0.39432525
142PRKACG0.39035900
143JAK20.38594280
144NEK90.38285983
145DYRK1B0.38256238
146CSNK1A1L0.37783003
147INSR0.37766694
148AURKB0.37547929
149CHEK20.37438928
150CDK60.37206188
151CAMK2G0.36842947
152FES0.35188355
153CHEK10.34839470
154VRK10.32925307
155CDK10.30338791
156ATR0.29178759
157CSNK1E0.27973766
158PRKDC0.27679195

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.74043976
2Protein export_Homo sapiens_hsa030605.00787190
3Sulfur metabolism_Homo sapiens_hsa009203.11611780
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.92323604
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.76953073
6Insulin secretion_Homo sapiens_hsa049112.27549552
7Non-homologous end-joining_Homo sapiens_hsa034502.27391392
8Vibrio cholerae infection_Homo sapiens_hsa051102.19083597
9Cocaine addiction_Homo sapiens_hsa050301.85054147
10RNA transport_Homo sapiens_hsa030131.79419960
11N-Glycan biosynthesis_Homo sapiens_hsa005101.67418504
12Cell cycle_Homo sapiens_hsa041101.63109747
13Type II diabetes mellitus_Homo sapiens_hsa049301.52149145
14Basal transcription factors_Homo sapiens_hsa030221.48684315
15Vitamin B6 metabolism_Homo sapiens_hsa007501.47902011
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46139260
17Hippo signaling pathway_Homo sapiens_hsa043901.45347691
18Oocyte meiosis_Homo sapiens_hsa041141.45335778
19Amphetamine addiction_Homo sapiens_hsa050311.44541534
20GABAergic synapse_Homo sapiens_hsa047271.43509038
21mRNA surveillance pathway_Homo sapiens_hsa030151.43091807
22Fanconi anemia pathway_Homo sapiens_hsa034601.41618137
23Type I diabetes mellitus_Homo sapiens_hsa049401.41393671
24Mismatch repair_Homo sapiens_hsa034301.37032502
25Butanoate metabolism_Homo sapiens_hsa006501.34788566
26Spliceosome_Homo sapiens_hsa030401.34506210
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32653174
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29484872
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26606042
30Proteasome_Homo sapiens_hsa030501.25094615
31Thyroid hormone synthesis_Homo sapiens_hsa049181.24367957
32Dopaminergic synapse_Homo sapiens_hsa047281.24329797
33RNA degradation_Homo sapiens_hsa030181.22480199
34TGF-beta signaling pathway_Homo sapiens_hsa043501.21504730
35Pancreatic secretion_Homo sapiens_hsa049721.20079235
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18643932
37Hedgehog signaling pathway_Homo sapiens_hsa043401.18503322
38Serotonergic synapse_Homo sapiens_hsa047261.17850467
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17785194
40Nicotine addiction_Homo sapiens_hsa050331.17385889
41Steroid biosynthesis_Homo sapiens_hsa001001.16992908
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15285559
43Collecting duct acid secretion_Homo sapiens_hsa049661.12471374
44Propanoate metabolism_Homo sapiens_hsa006401.07189620
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.04418275
46Synaptic vesicle cycle_Homo sapiens_hsa047211.03468963
47Tryptophan metabolism_Homo sapiens_hsa003801.03309760
48Prion diseases_Homo sapiens_hsa050201.03180110
49Morphine addiction_Homo sapiens_hsa050321.03039659
50Circadian entrainment_Homo sapiens_hsa047131.01435873
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01431581
52Renin secretion_Homo sapiens_hsa049241.01119753
53Long-term potentiation_Homo sapiens_hsa047201.00858095
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00745321
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99069331
56Lysosome_Homo sapiens_hsa041420.97437764
57Taste transduction_Homo sapiens_hsa047420.96633519
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.94727929
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93757944
60Nucleotide excision repair_Homo sapiens_hsa034200.92815364
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91188760
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90873828
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90709691
64Cholinergic synapse_Homo sapiens_hsa047250.89771917
65Adherens junction_Homo sapiens_hsa045200.88327994
66Phagosome_Homo sapiens_hsa041450.88300728
67p53 signaling pathway_Homo sapiens_hsa041150.88153473
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87778531
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87268489
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85297439
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82822051
72Complement and coagulation cascades_Homo sapiens_hsa046100.82569510
73Glutamatergic synapse_Homo sapiens_hsa047240.82277864
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80289354
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79744178
76Fatty acid elongation_Homo sapiens_hsa000620.79286140
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78326063
78Starch and sucrose metabolism_Homo sapiens_hsa005000.77016061
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75931302
80Protein digestion and absorption_Homo sapiens_hsa049740.74576784
81Basal cell carcinoma_Homo sapiens_hsa052170.74509673
82Selenocompound metabolism_Homo sapiens_hsa004500.74439101
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73817617
84Estrogen signaling pathway_Homo sapiens_hsa049150.73279838
85Wnt signaling pathway_Homo sapiens_hsa043100.72712398
86Biosynthesis of amino acids_Homo sapiens_hsa012300.72495730
87Fat digestion and absorption_Homo sapiens_hsa049750.71982637
88Glucagon signaling pathway_Homo sapiens_hsa049220.68541581
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67924276
90Sphingolipid metabolism_Homo sapiens_hsa006000.67153103
91Histidine metabolism_Homo sapiens_hsa003400.67058121
92Long-term depression_Homo sapiens_hsa047300.66512275
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65137127
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65101064
95Regulation of autophagy_Homo sapiens_hsa041400.62970849
96Colorectal cancer_Homo sapiens_hsa052100.61609446
97Other glycan degradation_Homo sapiens_hsa005110.57110817
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.56908179
99Tight junction_Homo sapiens_hsa045300.54786383
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54175608
101MicroRNAs in cancer_Homo sapiens_hsa052060.53776908
102RNA polymerase_Homo sapiens_hsa030200.52956702
103Rheumatoid arthritis_Homo sapiens_hsa053230.52847418
104Phenylalanine metabolism_Homo sapiens_hsa003600.52286266
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51989519
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51950856
107Renin-angiotensin system_Homo sapiens_hsa046140.51643784
108Tyrosine metabolism_Homo sapiens_hsa003500.50994337
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.48571998
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48562052
111Melanoma_Homo sapiens_hsa052180.48327213
112Axon guidance_Homo sapiens_hsa043600.47942335
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47641267
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46420338
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46293425
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46037666
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45978324
118ABC transporters_Homo sapiens_hsa020100.45725680
119Insulin resistance_Homo sapiens_hsa049310.45115965
120DNA replication_Homo sapiens_hsa030300.44751864
121Ovarian steroidogenesis_Homo sapiens_hsa049130.44501676
122Circadian rhythm_Homo sapiens_hsa047100.43741854
123Prolactin signaling pathway_Homo sapiens_hsa049170.43638220
124Carbon metabolism_Homo sapiens_hsa012000.42983748
125Folate biosynthesis_Homo sapiens_hsa007900.42958802
126Pyruvate metabolism_Homo sapiens_hsa006200.42915157
127Renal cell carcinoma_Homo sapiens_hsa052110.42847835
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42777455
129Gap junction_Homo sapiens_hsa045400.42294770
130Glioma_Homo sapiens_hsa052140.42227417
131Prostate cancer_Homo sapiens_hsa052150.42133408
132Alzheimers disease_Homo sapiens_hsa050100.42031665
133Ether lipid metabolism_Homo sapiens_hsa005650.40947370
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39750866
135Oxidative phosphorylation_Homo sapiens_hsa001900.39430181
136Salivary secretion_Homo sapiens_hsa049700.39184820
137cAMP signaling pathway_Homo sapiens_hsa040240.39144422
138Dorso-ventral axis formation_Homo sapiens_hsa043200.39094961
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.38937256
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37500373
141Alcoholism_Homo sapiens_hsa050340.37029579
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36750943
143Melanogenesis_Homo sapiens_hsa049160.35373056
144Fatty acid metabolism_Homo sapiens_hsa012120.35175223
145Focal adhesion_Homo sapiens_hsa045100.34596094
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34429028
147Gastric acid secretion_Homo sapiens_hsa049710.34305885
148Peroxisome_Homo sapiens_hsa041460.34204600
149Bile secretion_Homo sapiens_hsa049760.33866478
150ECM-receptor interaction_Homo sapiens_hsa045120.32423258
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31437147
152Purine metabolism_Homo sapiens_hsa002300.31180112

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