

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.92681249 |
| 2 | DNA replication initiation (GO:0006270) | 4.76424608 |
| 3 | DNA strand elongation (GO:0022616) | 4.67939439 |
| 4 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.67860273 |
| 5 | nucleobase biosynthetic process (GO:0046112) | 4.57496468 |
| 6 | DNA unwinding involved in DNA replication (GO:0006268) | 4.52439882 |
| 7 | protein localization to kinetochore (GO:0034501) | 4.46387738 |
| 8 | purine nucleobase biosynthetic process (GO:0009113) | 4.42624277 |
| 9 | DNA replication checkpoint (GO:0000076) | 4.34935838 |
| 10 | telomere maintenance via recombination (GO:0000722) | 4.32301560 |
| 11 | mitotic metaphase plate congression (GO:0007080) | 4.27010961 |
| 12 | mitotic recombination (GO:0006312) | 4.18186806 |
| 13 | CENP-A containing nucleosome assembly (GO:0034080) | 4.09165947 |
| 14 | nuclear pore organization (GO:0006999) | 4.07675860 |
| 15 | mitotic nuclear envelope disassembly (GO:0007077) | 4.07037315 |
| 16 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.06370716 |
| 17 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.06370716 |
| 18 | chromatin remodeling at centromere (GO:0031055) | 4.03367628 |
| 19 | formation of translation preinitiation complex (GO:0001731) | 4.02174630 |
| 20 | IMP biosynthetic process (GO:0006188) | 3.88571257 |
| 21 | nuclear pore complex assembly (GO:0051292) | 3.84872443 |
| 22 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.84849463 |
| 23 | DNA replication-independent nucleosome organization (GO:0034724) | 3.84849463 |
| 24 | kinetochore organization (GO:0051383) | 3.83842088 |
| 25 | telomere maintenance via telomere lengthening (GO:0010833) | 3.82706118 |
| 26 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.82288252 |
| 27 | protein localization to chromosome, centromeric region (GO:0071459) | 3.78174879 |
| 28 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.76840483 |
| 29 | nuclear envelope disassembly (GO:0051081) | 3.76840139 |
| 30 | membrane disassembly (GO:0030397) | 3.76840139 |
| 31 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.75625993 |
| 32 | metaphase plate congression (GO:0051310) | 3.73752248 |
| 33 | mitotic sister chromatid segregation (GO:0000070) | 3.70365370 |
| 34 | mitotic chromosome condensation (GO:0007076) | 3.66649973 |
| 35 | ribosome biogenesis (GO:0042254) | 3.64243906 |
| 36 | regulation of spindle organization (GO:0090224) | 3.63049543 |
| 37 | ribosomal small subunit assembly (GO:0000028) | 3.60938278 |
| 38 | ribosome assembly (GO:0042255) | 3.59284169 |
| 39 | maturation of SSU-rRNA (GO:0030490) | 3.58804579 |
| 40 | DNA ligation (GO:0006266) | 3.58097655 |
| 41 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.57635979 |
| 42 | DNA deamination (GO:0045006) | 3.52849378 |
| 43 | establishment of chromosome localization (GO:0051303) | 3.51665904 |
| 44 | DNA double-strand break processing (GO:0000729) | 3.51500759 |
| 45 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.49824050 |
| 46 | negative regulation of ligase activity (GO:0051352) | 3.49824050 |
| 47 | sister chromatid segregation (GO:0000819) | 3.42420806 |
| 48 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.41723614 |
| 49 | kinetochore assembly (GO:0051382) | 3.41067174 |
| 50 | IMP metabolic process (GO:0046040) | 3.40062317 |
| 51 | histone exchange (GO:0043486) | 3.38376951 |
| 52 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.38018818 |
| 53 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.37538385 |
| 54 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.37538385 |
| 55 | mitotic sister chromatid cohesion (GO:0007064) | 3.36390252 |
| 56 | maturation of 5.8S rRNA (GO:0000460) | 3.34334176 |
| 57 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.33947277 |
| 58 | non-recombinational repair (GO:0000726) | 3.33947277 |
| 59 | establishment of viral latency (GO:0019043) | 3.32687309 |
| 60 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.32137084 |
| 61 | regulation of helicase activity (GO:0051095) | 3.31525013 |
| 62 | regulation of centrosome cycle (GO:0046605) | 3.27355199 |
| 63 | spindle checkpoint (GO:0031577) | 3.26954963 |
| 64 | meiotic chromosome segregation (GO:0045132) | 3.26676632 |
| 65 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.24976025 |
| 66 | regulation of mitochondrial translation (GO:0070129) | 3.24413111 |
| 67 | pseudouridine synthesis (GO:0001522) | 3.24338301 |
| 68 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.23981120 |
| 69 | positive regulation of chromosome segregation (GO:0051984) | 3.22797528 |
| 70 | DNA geometric change (GO:0032392) | 3.22768309 |
| 71 | DNA duplex unwinding (GO:0032508) | 3.22257705 |
| 72 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.21891570 |
| 73 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.21891570 |
| 74 | telomere maintenance (GO:0000723) | 3.20843711 |
| 75 | telomere organization (GO:0032200) | 3.20352003 |
| 76 | negative regulation of chromosome segregation (GO:0051985) | 3.19898407 |
| 77 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.19678152 |
| 78 | spliceosomal snRNP assembly (GO:0000387) | 3.19538480 |
| 79 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.18677419 |
| 80 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.18677419 |
| 81 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.18677419 |
| 82 | negative regulation of sister chromatid segregation (GO:0033046) | 3.18677419 |
| 83 | spindle assembly checkpoint (GO:0071173) | 3.16957776 |
| 84 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.15074492 |
| 85 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.14077248 |
| 86 | regulation of chromosome segregation (GO:0051983) | 3.13817171 |
| 87 | mitotic spindle assembly checkpoint (GO:0007094) | 3.13295858 |
| 88 | regulation of centriole replication (GO:0046599) | 3.13261830 |
| 89 | proteasome assembly (GO:0043248) | 3.12957122 |
| 90 | ribosomal small subunit biogenesis (GO:0042274) | 3.12840153 |
| 91 | rRNA processing (GO:0006364) | 3.12495204 |
| 92 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.12197051 |
| 93 | protein K6-linked ubiquitination (GO:0085020) | 3.11492193 |
| 94 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.11454048 |
| 95 | cell cycle G1/S phase transition (GO:0044843) | 3.11454048 |
| 96 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.11114447 |
| 97 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.10235472 |
| 98 | ribosomal large subunit biogenesis (GO:0042273) | 3.09270042 |
| 99 | mitotic spindle checkpoint (GO:0071174) | 3.09216732 |
| 100 | pore complex assembly (GO:0046931) | 3.09073230 |
| 101 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.08575689 |
| 102 | replication fork processing (GO:0031297) | 3.05147407 |
| 103 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.04837495 |
| 104 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.04763010 |
| 105 | mismatch repair (GO:0006298) | 3.04364469 |
| 106 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.04347921 |
| 107 | protein complex localization (GO:0031503) | 3.03388187 |
| 108 | postreplication repair (GO:0006301) | 3.03282505 |
| 109 | chromatin assembly or disassembly (GO:0006333) | 3.02922033 |
| 110 | regulation of mitotic spindle organization (GO:0060236) | 3.02065210 |
| 111 | DNA topological change (GO:0006265) | 3.02012839 |
| 112 | rRNA metabolic process (GO:0016072) | 3.01403636 |
| 113 | chromosome segregation (GO:0007059) | 3.00619874 |
| 114 | termination of RNA polymerase II transcription (GO:0006369) | 3.00187110 |
| 115 | positive regulation of ligase activity (GO:0051351) | 2.99928874 |
| 116 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.98241892 |
| 117 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.97237821 |
| 118 | regulation of sister chromatid segregation (GO:0033045) | 2.95887146 |
| 119 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.95887146 |
| 120 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.95887146 |
| 121 | establishment of integrated proviral latency (GO:0075713) | 2.94137446 |
| 122 | translesion synthesis (GO:0019985) | 2.90068770 |
| 123 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.89990576 |
| 124 | regulation of translation in response to stress (GO:0043555) | 2.88644503 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.43546722 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.42525644 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.16273262 |
| 4 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.91395148 |
| 5 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.45111030 |
| 6 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.27539408 |
| 7 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.25627513 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.02372656 |
| 9 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.88999454 |
| 10 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.82028916 |
| 11 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.81518961 |
| 12 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.72856998 |
| 13 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.70188128 |
| 14 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.69085700 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.65942900 |
| 16 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.44615362 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.40552750 |
| 18 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.28339509 |
| 19 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.25892466 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.24382515 |
| 21 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.23220889 |
| 22 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.21270448 |
| 23 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.12900322 |
| 24 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.09641538 |
| 25 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.02714792 |
| 26 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.00548684 |
| 27 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.99159612 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.97838822 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.94454332 |
| 30 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.94440696 |
| 31 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.90208975 |
| 32 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.88260415 |
| 33 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.81400868 |
| 34 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.80876872 |
| 35 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.80828741 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.80611624 |
| 37 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.78423430 |
| 38 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.75154276 |
| 39 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.74993383 |
| 40 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.73089154 |
| 41 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.72632579 |
| 42 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.72467192 |
| 43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.62654597 |
| 44 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.60382439 |
| 45 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.57852785 |
| 46 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.55130324 |
| 47 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.54934208 |
| 48 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.48444572 |
| 49 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.48048044 |
| 50 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.46162613 |
| 51 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.46078986 |
| 52 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.45972315 |
| 53 | MYC_22102868_ChIP-Seq_BL_Human | 1.45516710 |
| 54 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.37076653 |
| 55 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.31680345 |
| 56 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.31080709 |
| 57 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.29649508 |
| 58 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.28975537 |
| 59 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.28517200 |
| 60 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.25562065 |
| 61 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.25240076 |
| 62 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.24904719 |
| 63 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.22091185 |
| 64 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.22069609 |
| 65 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.21905242 |
| 66 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.20673904 |
| 67 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.19297147 |
| 68 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.16812807 |
| 69 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.16533698 |
| 70 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.16443337 |
| 71 | * TFEB_21752829_ChIP-Seq_HELA_Human | 1.15250975 |
| 72 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.11510440 |
| 73 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.11183839 |
| 74 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.10785819 |
| 75 | EWS_26573619_Chip-Seq_HEK293_Human | 1.10320519 |
| 76 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.08923831 |
| 77 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.07917654 |
| 78 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.07307423 |
| 79 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.07069281 |
| 80 | FUS_26573619_Chip-Seq_HEK293_Human | 1.04564826 |
| 81 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.03243503 |
| 82 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.03164727 |
| 83 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.00148877 |
| 84 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.98786964 |
| 85 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.98523343 |
| 86 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.97899990 |
| 87 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.97179544 |
| 88 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.95893946 |
| 89 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.95403851 |
| 90 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.93654802 |
| 91 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.93385670 |
| 92 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.93328577 |
| 93 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.93305931 |
| 94 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.92198749 |
| 95 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.90543986 |
| 96 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.88937163 |
| 97 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.88200756 |
| 98 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.88004334 |
| 99 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.85129695 |
| 100 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.84907705 |
| 101 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.84230978 |
| 102 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.83904535 |
| 103 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.82786191 |
| 104 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.81062347 |
| 105 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.80969512 |
| 106 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.80113526 |
| 107 | * CHD1_26751641_Chip-Seq_LNCaP_Human | 0.77711668 |
| 108 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.75914940 |
| 109 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.75073114 |
| 110 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.75036854 |
| 111 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.74732647 |
| 112 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.74707386 |
| 113 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.73980445 |
| 114 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.70800624 |
| 115 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.68487716 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.46261284 |
| 2 | MP0010094_abnormal_chromosome_stability | 5.18536640 |
| 3 | MP0003111_abnormal_nucleus_morphology | 4.83117014 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 4.44506266 |
| 5 | MP0003077_abnormal_cell_cycle | 4.38992089 |
| 6 | MP0008057_abnormal_DNA_replication | 4.33187764 |
| 7 | MP0008058_abnormal_DNA_repair | 3.69453368 |
| 8 | MP0008007_abnormal_cellular_replicative | 3.27207608 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.68226292 |
| 10 | MP0008877_abnormal_DNA_methylation | 2.53698459 |
| 11 | MP0009697_abnormal_copulation | 2.48408442 |
| 12 | MP0001730_embryonic_growth_arrest | 2.47535707 |
| 13 | MP0003123_paternal_imprinting | 2.46113133 |
| 14 | MP0002396_abnormal_hematopoietic_system | 2.38899274 |
| 15 | MP0000350_abnormal_cell_proliferation | 2.34014042 |
| 16 | MP0010352_gastrointestinal_tract_polyps | 2.24822527 |
| 17 | MP0003786_premature_aging | 2.15384407 |
| 18 | MP0010307_abnormal_tumor_latency | 2.09356866 |
| 19 | MP0005380_embryogenesis_phenotype | 1.82081931 |
| 20 | MP0001672_abnormal_embryogenesis/_devel | 1.82081931 |
| 21 | MP0001697_abnormal_embryo_size | 1.74296927 |
| 22 | MP0000490_abnormal_crypts_of | 1.69953794 |
| 23 | MP0003984_embryonic_growth_retardation | 1.67603580 |
| 24 | MP0002088_abnormal_embryonic_growth/wei | 1.62653829 |
| 25 | MP0002080_prenatal_lethality | 1.61401337 |
| 26 | MP0006036_abnormal_mitochondrial_physio | 1.60940873 |
| 27 | MP0004808_abnormal_hematopoietic_stem | 1.60573201 |
| 28 | MP0003718_maternal_effect | 1.58284240 |
| 29 | MP0000313_abnormal_cell_death | 1.54891488 |
| 30 | MP0009333_abnormal_splenocyte_physiolog | 1.49535190 |
| 31 | MP0003763_abnormal_thymus_physiology | 1.49059590 |
| 32 | MP0002019_abnormal_tumor_incidence | 1.47409470 |
| 33 | MP0003121_genomic_imprinting | 1.46516334 |
| 34 | MP0002085_abnormal_embryonic_tissue | 1.45824166 |
| 35 | MP0002086_abnormal_extraembryonic_tissu | 1.41797169 |
| 36 | MP0002084_abnormal_developmental_patter | 1.37634814 |
| 37 | MP0004197_abnormal_fetal_growth/weight/ | 1.36890739 |
| 38 | MP0002398_abnormal_bone_marrow | 1.26733378 |
| 39 | MP0001529_abnormal_vocalization | 1.26244710 |
| 40 | MP0000703_abnormal_thymus_morphology | 1.25407399 |
| 41 | MP0003890_abnormal_embryonic-extraembry | 1.22884329 |
| 42 | MP0003567_abnormal_fetal_cardiomyocyte | 1.19427718 |
| 43 | MP0002210_abnormal_sex_determination | 1.18859117 |
| 44 | MP0005397_hematopoietic_system_phenotyp | 1.16042448 |
| 45 | MP0001545_abnormal_hematopoietic_system | 1.16042448 |
| 46 | MP0002722_abnormal_immune_system | 1.15742948 |
| 47 | MP0005076_abnormal_cell_differentiation | 1.13881587 |
| 48 | MP0008995_early_reproductive_senescence | 1.13347121 |
| 49 | MP0002938_white_spotting | 1.11406776 |
| 50 | MP0003315_abnormal_perineum_morphology | 1.08897057 |
| 51 | MP0000689_abnormal_spleen_morphology | 1.08726118 |
| 52 | MP0006072_abnormal_retinal_apoptosis | 1.05485457 |
| 53 | MP0002009_preneoplasia | 1.04792685 |
| 54 | MP0003806_abnormal_nucleotide_metabolis | 1.04678821 |
| 55 | MP0001145_abnormal_male_reproductive | 1.03424151 |
| 56 | MP0000647_abnormal_sebaceous_gland | 1.03178594 |
| 57 | MP0001346_abnormal_lacrimal_gland | 1.02847176 |
| 58 | MP0008789_abnormal_olfactory_epithelium | 1.02489695 |
| 59 | MP0001293_anophthalmia | 1.00686762 |
| 60 | MP0003941_abnormal_skin_development | 0.97122730 |
| 61 | MP0002233_abnormal_nose_morphology | 0.96364386 |
| 62 | MP0002429_abnormal_blood_cell | 0.95330842 |
| 63 | MP0003221_abnormal_cardiomyocyte_apopto | 0.93041563 |
| 64 | MP0005384_cellular_phenotype | 0.92878619 |
| 65 | MP0002697_abnormal_eye_size | 0.92551221 |
| 66 | MP0005621_abnormal_cell_physiology | 0.89775508 |
| 67 | MP0001929_abnormal_gametogenesis | 0.89181135 |
| 68 | MP0005671_abnormal_response_to | 0.89129849 |
| 69 | MP0003186_abnormal_redox_activity | 0.89003809 |
| 70 | MP0002163_abnormal_gland_morphology | 0.87301437 |
| 71 | MP0002234_abnormal_pharynx_morphology | 0.86991659 |
| 72 | MP0000653_abnormal_sex_gland | 0.86667119 |
| 73 | MP0003136_yellow_coat_color | 0.86344970 |
| 74 | MP0005187_abnormal_penis_morphology | 0.85802091 |
| 75 | MP0000858_altered_metastatic_potential | 0.85402612 |
| 76 | MP0000358_abnormal_cell_content/ | 0.85156430 |
| 77 | MP0000716_abnormal_immune_system | 0.83268819 |
| 78 | MP0001764_abnormal_homeostasis | 0.82406717 |
| 79 | MP0001119_abnormal_female_reproductive | 0.82078198 |
| 80 | MP0002160_abnormal_reproductive_system | 0.80994620 |
| 81 | MP0001835_abnormal_antigen_presentation | 0.80259887 |
| 82 | MP0006292_abnormal_olfactory_placode | 0.78518243 |
| 83 | MP0009672_abnormal_birth_weight | 0.76759053 |
| 84 | MP0005389_reproductive_system_phenotype | 0.76613176 |
| 85 | MP0001800_abnormal_humoral_immune | 0.75032274 |
| 86 | MP0009703_decreased_birth_body | 0.72098172 |
| 87 | MP0003119_abnormal_digestive_system | 0.71646064 |
| 88 | MP0005023_abnormal_wound_healing | 0.70973475 |
| 89 | MP0002420_abnormal_adaptive_immunity | 0.70621873 |
| 90 | MP0003698_abnormal_male_reproductive | 0.70295718 |
| 91 | MP0003755_abnormal_palate_morphology | 0.69960516 |
| 92 | MP0001853_heart_inflammation | 0.69431610 |
| 93 | MP0001819_abnormal_immune_cell | 0.69306231 |
| 94 | MP0003787_abnormal_imprinting | 0.69096845 |
| 95 | MP0002090_abnormal_vision | 0.68524342 |
| 96 | MP0000428_abnormal_craniofacial_morphol | 0.68202154 |
| 97 | MP0005394_taste/olfaction_phenotype | 0.67781891 |
| 98 | MP0005499_abnormal_olfactory_system | 0.67781891 |
| 99 | MP0004233_abnormal_muscle_weight | 0.67452200 |
| 100 | MP0003566_abnormal_cell_adhesion | 0.66454049 |
| 101 | MP0005501_abnormal_skin_physiology | 0.65879721 |
| 102 | MP0002095_abnormal_skin_pigmentation | 0.65775792 |
| 103 | MP0002452_abnormal_antigen_presenting | 0.65594845 |
| 104 | MP0001915_intracranial_hemorrhage | 0.64733068 |
| 105 | MP0002111_abnormal_tail_morphology | 0.62606087 |
| 106 | MP0001727_abnormal_embryo_implantation | 0.62151617 |
| 107 | MP0006054_spinal_hemorrhage | 0.61597974 |
| 108 | MP0001661_extended_life_span | 0.61390375 |
| 109 | MP0001188_hyperpigmentation | 0.61256552 |
| 110 | MP0004133_heterotaxia | 0.60870129 |
| 111 | MP0005395_other_phenotype | 0.60678608 |
| 112 | MP0002161_abnormal_fertility/fecundity | 0.60158309 |
| 113 | MP0002075_abnormal_coat/hair_pigmentati | 0.59596594 |
| 114 | MP0001919_abnormal_reproductive_system | 0.59358063 |
| 115 | MP0000372_irregular_coat_pigmentation | 0.58972035 |
| 116 | MP0003699_abnormal_female_reproductive | 0.58590427 |
| 117 | MP0001849_ear_inflammation | 0.58135716 |
| 118 | MP0009379_abnormal_foot_pigmentation | 0.58119040 |
| 119 | MP0001186_pigmentation_phenotype | 0.58095427 |
| 120 | MP0000477_abnormal_intestine_morphology | 0.57509966 |
| 121 | MP0002796_impaired_skin_barrier | 0.57191854 |
| 122 | MP0005408_hypopigmentation | 0.57153004 |
| 123 | MP0003937_abnormal_limbs/digits/tail_de | 0.57001448 |
| 124 | MP0010030_abnormal_orbit_morphology | 0.56914145 |
| 125 | MP0000049_abnormal_middle_ear | 0.56848078 |
| 126 | MP0002405_respiratory_system_inflammati | 0.56633083 |
| 127 | MP0005391_vision/eye_phenotype | 0.56571892 |
| 128 | MP0004147_increased_porphyrin_level | 0.56524194 |
| 129 | MP0002092_abnormal_eye_morphology | 0.56377199 |
| 130 | MP0003448_altered_tumor_morphology | 0.54884650 |
| 131 | MP0002132_abnormal_respiratory_system | 0.54750208 |
| 132 | MP0004084_abnormal_cardiac_muscle | 0.54265205 |
| 133 | MP0002723_abnormal_immune_serum | 0.51499588 |
| 134 | MP0000015_abnormal_ear_pigmentation | 0.51187780 |
| 135 | MP0000537_abnormal_urethra_morphology | 0.51140961 |
| 136 | MP0001286_abnormal_eye_development | 0.50758499 |
| 137 | MP0006035_abnormal_mitochondrial_morpho | 0.50339226 |
| 138 | MP0005075_abnormal_melanosome_morpholog | 0.49527527 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.23125678 |
| 2 | Chromsome breakage (HP:0040012) | 3.92423463 |
| 3 | Breast hypoplasia (HP:0003187) | 3.84244270 |
| 4 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.74582359 |
| 5 | Abnormality of chromosome stability (HP:0003220) | 3.69667335 |
| 6 | Meckel diverticulum (HP:0002245) | 3.62471238 |
| 7 | Abnormality of the preputium (HP:0100587) | 3.56377612 |
| 8 | Abnormality of the ileum (HP:0001549) | 3.44546259 |
| 9 | Acute necrotizing encephalopathy (HP:0006965) | 3.41833947 |
| 10 | Microvesicular hepatic steatosis (HP:0001414) | 3.41439685 |
| 11 | Abnormality of the anterior horn cell (HP:0006802) | 3.39063919 |
| 12 | Degeneration of anterior horn cells (HP:0002398) | 3.39063919 |
| 13 | Oral leukoplakia (HP:0002745) | 3.36073753 |
| 14 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.35986944 |
| 15 | Medulloblastoma (HP:0002885) | 3.32658304 |
| 16 | Agnosia (HP:0010524) | 3.30504741 |
| 17 | Reticulocytopenia (HP:0001896) | 3.29556990 |
| 18 | Colon cancer (HP:0003003) | 3.28801003 |
| 19 | Cerebral hypomyelination (HP:0006808) | 3.26259130 |
| 20 | Patellar aplasia (HP:0006443) | 3.21707633 |
| 21 | Acute encephalopathy (HP:0006846) | 3.18680054 |
| 22 | Selective tooth agenesis (HP:0001592) | 3.17602581 |
| 23 | Ependymoma (HP:0002888) | 3.16640358 |
| 24 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.16226930 |
| 25 | Myelodysplasia (HP:0002863) | 3.10525943 |
| 26 | Carpal bone hypoplasia (HP:0001498) | 3.03416443 |
| 27 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.99638843 |
| 28 | Small intestinal stenosis (HP:0012848) | 2.92413044 |
| 29 | Duodenal stenosis (HP:0100867) | 2.92413044 |
| 30 | Absent thumb (HP:0009777) | 2.91965502 |
| 31 | Aplastic anemia (HP:0001915) | 2.83716242 |
| 32 | Increased CSF lactate (HP:0002490) | 2.83587614 |
| 33 | Increased hepatocellular lipid droplets (HP:0006565) | 2.82474415 |
| 34 | Bone marrow hypocellularity (HP:0005528) | 2.81006466 |
| 35 | Progressive macrocephaly (HP:0004481) | 2.77746058 |
| 36 | Abnormality of the labia minora (HP:0012880) | 2.75814397 |
| 37 | Rough bone trabeculation (HP:0100670) | 2.75102791 |
| 38 | Mitochondrial inheritance (HP:0001427) | 2.66354511 |
| 39 | Lipid accumulation in hepatocytes (HP:0006561) | 2.65286551 |
| 40 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.63360370 |
| 41 | Absent radius (HP:0003974) | 2.63217250 |
| 42 | Increased serum pyruvate (HP:0003542) | 2.62629957 |
| 43 | Premature graying of hair (HP:0002216) | 2.62432876 |
| 44 | Impulsivity (HP:0100710) | 2.60964602 |
| 45 | Reduced antithrombin III activity (HP:0001976) | 2.58787455 |
| 46 | Abnormal number of erythroid precursors (HP:0012131) | 2.57950073 |
| 47 | Cerebral edema (HP:0002181) | 2.53582560 |
| 48 | 11 pairs of ribs (HP:0000878) | 2.52368484 |
| 49 | Abnormality of glycolysis (HP:0004366) | 2.51668067 |
| 50 | Rhabdomyosarcoma (HP:0002859) | 2.48621864 |
| 51 | Sloping forehead (HP:0000340) | 2.46915907 |
| 52 | Abnormality of DNA repair (HP:0003254) | 2.46449802 |
| 53 | Absent forearm bone (HP:0003953) | 2.42114332 |
| 54 | Aplasia involving forearm bones (HP:0009822) | 2.42114332 |
| 55 | Basal cell carcinoma (HP:0002671) | 2.39232428 |
| 56 | Stenosis of the external auditory canal (HP:0000402) | 2.38598112 |
| 57 | Increased serum lactate (HP:0002151) | 2.35585843 |
| 58 | Abnormality of the duodenum (HP:0002246) | 2.35506856 |
| 59 | Abnormal lung lobation (HP:0002101) | 2.34749912 |
| 60 | Cellular immunodeficiency (HP:0005374) | 2.32482471 |
| 61 | Neoplasm of the pancreas (HP:0002894) | 2.30840733 |
| 62 | Abnormality of methionine metabolism (HP:0010901) | 2.29930183 |
| 63 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.27006082 |
| 64 | Hepatocellular necrosis (HP:0001404) | 2.26040011 |
| 65 | Deviation of the thumb (HP:0009603) | 2.24586922 |
| 66 | Abnormality of the carotid arteries (HP:0005344) | 2.23846195 |
| 67 | Tracheoesophageal fistula (HP:0002575) | 2.22136100 |
| 68 | Proximal placement of thumb (HP:0009623) | 2.20854142 |
| 69 | Pancytopenia (HP:0001876) | 2.18653386 |
| 70 | Amaurosis fugax (HP:0100576) | 2.16680798 |
| 71 | Lymphoma (HP:0002665) | 2.16146163 |
| 72 | Sensory axonal neuropathy (HP:0003390) | 2.15508231 |
| 73 | Type I transferrin isoform profile (HP:0003642) | 2.14922259 |
| 74 | Embryonal renal neoplasm (HP:0011794) | 2.14140864 |
| 75 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.13724652 |
| 76 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.13724652 |
| 77 | Cleft eyelid (HP:0000625) | 2.13679615 |
| 78 | Glioma (HP:0009733) | 2.13635127 |
| 79 | Cafe-au-lait spot (HP:0000957) | 2.13059709 |
| 80 | Ectopic kidney (HP:0000086) | 2.09092186 |
| 81 | Clubbing of toes (HP:0100760) | 2.08632434 |
| 82 | Volvulus (HP:0002580) | 2.08069735 |
| 83 | Thrombocytosis (HP:0001894) | 2.07806781 |
| 84 | Increased nuchal translucency (HP:0010880) | 2.07653368 |
| 85 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.07521947 |
| 86 | Horseshoe kidney (HP:0000085) | 2.03088687 |
| 87 | Hepatic necrosis (HP:0002605) | 2.02329730 |
| 88 | Multiple enchondromatosis (HP:0005701) | 2.02311423 |
| 89 | Leukodystrophy (HP:0002415) | 2.02169277 |
| 90 | Abnormal trabecular bone morphology (HP:0100671) | 2.01984768 |
| 91 | Triphalangeal thumb (HP:0001199) | 2.00799372 |
| 92 | Macrocytic anemia (HP:0001972) | 2.00752200 |
| 93 | Premature ovarian failure (HP:0008209) | 2.00056790 |
| 94 | Abnormality of the astrocytes (HP:0100707) | 1.99730222 |
| 95 | Astrocytoma (HP:0009592) | 1.99730222 |
| 96 | High pitched voice (HP:0001620) | 1.98258767 |
| 97 | Trismus (HP:0000211) | 1.97998942 |
| 98 | Short thumb (HP:0009778) | 1.97331915 |
| 99 | Microretrognathia (HP:0000308) | 1.97315208 |
| 100 | Postnatal microcephaly (HP:0005484) | 1.97250305 |
| 101 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.96513240 |
| 102 | Abnormal number of incisors (HP:0011064) | 1.96250853 |
| 103 | Squamous cell carcinoma (HP:0002860) | 1.95772295 |
| 104 | Lactic acidosis (HP:0003128) | 1.95160313 |
| 105 | Atresia of the external auditory canal (HP:0000413) | 1.94886012 |
| 106 | Abnormal protein glycosylation (HP:0012346) | 1.94881623 |
| 107 | Abnormal glycosylation (HP:0012345) | 1.94881623 |
| 108 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.94881623 |
| 109 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.94881623 |
| 110 | Pallor (HP:0000980) | 1.93802389 |
| 111 | Neoplasm of the colon (HP:0100273) | 1.92662610 |
| 112 | Abnormality of serum amino acid levels (HP:0003112) | 1.91839369 |
| 113 | IgM deficiency (HP:0002850) | 1.91788055 |
| 114 | Supernumerary spleens (HP:0009799) | 1.91493890 |
| 115 | Missing ribs (HP:0000921) | 1.88977441 |
| 116 | Duplicated collecting system (HP:0000081) | 1.88759832 |
| 117 | Abnormality of the septum pellucidum (HP:0007375) | 1.86800351 |
| 118 | Homocystinuria (HP:0002156) | 1.86782113 |
| 119 | Abnormality of homocysteine metabolism (HP:0010919) | 1.86782113 |
| 120 | Exercise intolerance (HP:0003546) | 1.86699633 |
| 121 | Progressive muscle weakness (HP:0003323) | 1.85444805 |
| 122 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.82605310 |
| 123 | Secondary amenorrhea (HP:0000869) | 1.80745150 |
| 124 | Megaloblastic anemia (HP:0001889) | 1.80714199 |
| 125 | Choanal atresia (HP:0000453) | 1.80486607 |
| 126 | Methylmalonic acidemia (HP:0002912) | 1.80439196 |
| 127 | Slender long bone (HP:0003100) | 1.80436755 |
| 128 | Neoplasm of the oral cavity (HP:0100649) | 1.80182188 |
| 129 | Facial cleft (HP:0002006) | 1.79381082 |
| 130 | Prominent nose (HP:0000448) | 1.78922961 |
| 131 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.77855094 |
| 132 | Absent epiphyses (HP:0010577) | 1.77009163 |
| 133 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.77009163 |
| 134 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.74490175 |
| 135 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.72887007 |
| 136 | Abnormality of the pons (HP:0007361) | 1.72876613 |
| 137 | Increased intramyocellular lipid droplets (HP:0012240) | 1.72838316 |
| 138 | Irregular epiphyses (HP:0010582) | 1.72468685 |
| 139 | CNS hypomyelination (HP:0003429) | 1.71593688 |
| 140 | Neoplasm of striated muscle (HP:0009728) | 1.71481234 |
| 141 | Spinal muscular atrophy (HP:0007269) | 1.71176628 |
| 142 | Abnormal spermatogenesis (HP:0008669) | 1.70686101 |
| 143 | Leukopenia (HP:0001882) | 1.69530160 |
| 144 | Abnormality of alanine metabolism (HP:0010916) | 1.68894226 |
| 145 | Hyperalaninemia (HP:0003348) | 1.68894226 |
| 146 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.68894226 |
| 147 | Biliary tract neoplasm (HP:0100574) | 1.66867936 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.82404333 |
| 2 | WEE1 | 4.35997193 |
| 3 | CDC7 | 4.34486318 |
| 4 | EIF2AK1 | 3.08127030 |
| 5 | SRPK1 | 3.05631535 |
| 6 | TSSK6 | 3.05436923 |
| 7 | NEK2 | 2.80288722 |
| 8 | NEK1 | 2.67231015 |
| 9 | PLK4 | 2.53903036 |
| 10 | MST4 | 2.43399726 |
| 11 | TRIM28 | 2.38776971 |
| 12 | TTK | 2.36559520 |
| 13 | BRSK2 | 2.32314245 |
| 14 | ACVR1B | 2.16042448 |
| 15 | VRK2 | 2.14791565 |
| 16 | PLK1 | 2.13172728 |
| 17 | EIF2AK3 | 1.97478012 |
| 18 | PLK3 | 1.81540448 |
| 19 | STK16 | 1.79400938 |
| 20 | VRK1 | 1.75367200 |
| 21 | ATR | 1.73372760 |
| 22 | AURKB | 1.72822356 |
| 23 | CCNB1 | 1.57077986 |
| 24 | PASK | 1.54831230 |
| 25 | RPS6KB2 | 1.54009076 |
| 26 | TESK2 | 1.53463956 |
| 27 | MKNK1 | 1.53403958 |
| 28 | CDK7 | 1.48713318 |
| 29 | BRSK1 | 1.47942723 |
| 30 | ZAK | 1.43033715 |
| 31 | CHEK2 | 1.39673152 |
| 32 | EPHA2 | 1.37483157 |
| 33 | NME2 | 1.37097191 |
| 34 | CDK12 | 1.30005431 |
| 35 | TLK1 | 1.28971420 |
| 36 | CDK4 | 1.27592068 |
| 37 | CHEK1 | 1.26394923 |
| 38 | NME1 | 1.26176337 |
| 39 | STK10 | 1.24653137 |
| 40 | MAP3K8 | 1.22363613 |
| 41 | AURKA | 1.22284762 |
| 42 | RPS6KA4 | 1.15354767 |
| 43 | MKNK2 | 1.15160922 |
| 44 | SCYL2 | 1.12473509 |
| 45 | MAP3K10 | 1.11296552 |
| 46 | STK4 | 1.08838899 |
| 47 | NUAK1 | 1.07656332 |
| 48 | MAP4K2 | 0.94510711 |
| 49 | DYRK3 | 0.93688606 |
| 50 | ATM | 0.93580621 |
| 51 | PAK4 | 0.88156505 |
| 52 | TGFBR1 | 0.87637931 |
| 53 | PIM1 | 0.86805320 |
| 54 | MAP4K1 | 0.83859057 |
| 55 | CDK2 | 0.82584230 |
| 56 | MAP3K12 | 0.82264203 |
| 57 | BMPR1B | 0.82084776 |
| 58 | BRD4 | 0.79591150 |
| 59 | TAOK2 | 0.79418638 |
| 60 | EEF2K | 0.77799177 |
| 61 | EIF2AK2 | 0.77239827 |
| 62 | CDK3 | 0.76574288 |
| 63 | TAF1 | 0.73524199 |
| 64 | ALK | 0.73335878 |
| 65 | PBK | 0.73129187 |
| 66 | CSNK1G1 | 0.68172742 |
| 67 | CSNK1G3 | 0.64921576 |
| 68 | CDK1 | 0.64248534 |
| 69 | PIM2 | 0.62903142 |
| 70 | TESK1 | 0.62436669 |
| 71 | CLK1 | 0.62057704 |
| 72 | CSNK2A1 | 0.61929275 |
| 73 | ERBB4 | 0.61868428 |
| 74 | CSNK2A2 | 0.61386748 |
| 75 | TNIK | 0.60274085 |
| 76 | WNK3 | 0.58099107 |
| 77 | TXK | 0.57671239 |
| 78 | CDK8 | 0.57452930 |
| 79 | FLT3 | 0.56994162 |
| 80 | PAK1 | 0.55111978 |
| 81 | CDK6 | 0.54703120 |
| 82 | AKT3 | 0.53979691 |
| 83 | RPS6KA5 | 0.52624765 |
| 84 | CSNK1A1L | 0.52020703 |
| 85 | MELK | 0.51905047 |
| 86 | BCR | 0.51808139 |
| 87 | CSNK1E | 0.51643279 |
| 88 | BRAF | 0.51032177 |
| 89 | STK3 | 0.47818189 |
| 90 | YES1 | 0.47451235 |
| 91 | KDR | 0.46846875 |
| 92 | PRKCI | 0.46818900 |
| 93 | MAP2K7 | 0.45728558 |
| 94 | CSNK1G2 | 0.45368094 |
| 95 | STK38L | 0.42638546 |
| 96 | LRRK2 | 0.41376620 |
| 97 | PDK3 | 0.39261156 |
| 98 | PDK4 | 0.39261156 |
| 99 | ZAP70 | 0.38354588 |
| 100 | LATS1 | 0.38180485 |
| 101 | PDK2 | 0.37234346 |
| 102 | ERBB3 | 0.35887436 |
| 103 | STK24 | 0.35873972 |
| 104 | MAP3K4 | 0.35546004 |
| 105 | PRKDC | 0.34817231 |
| 106 | IRAK3 | 0.34623892 |
| 107 | TEC | 0.34431320 |
| 108 | BTK | 0.33366645 |
| 109 | ILK | 0.32925540 |
| 110 | FGFR1 | 0.32714018 |
| 111 | ITK | 0.31055012 |
| 112 | LIMK1 | 0.30600842 |
| 113 | FGFR4 | 0.30101678 |
| 114 | GRK6 | 0.29685849 |
| 115 | PNCK | 0.29379133 |
| 116 | MARK3 | 0.29216777 |
| 117 | RAF1 | 0.28727465 |
| 118 | PLK2 | 0.27773581 |
| 119 | DYRK2 | 0.26803455 |
| 120 | AKT2 | 0.26454720 |
| 121 | NEK9 | 0.26364183 |
| 122 | MAP3K5 | 0.26094416 |
| 123 | NEK6 | 0.25440845 |
| 124 | LYN | 0.23503740 |
| 125 | JAK3 | 0.22056646 |
| 126 | PKN2 | 0.21230054 |
| 127 | MAPK14 | 0.21150268 |
| 128 | DAPK1 | 0.20943285 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.17001186 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.47503423 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.77863137 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.30216889 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.26368964 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.23884187 |
| 7 | Nucleotide excision repair_Homo sapiens_hsa03420 | 3.14799693 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 3.11655801 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 3.05519098 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 3.03328350 |
| 11 | Cell cycle_Homo sapiens_hsa04110 | 2.85346267 |
| 12 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.73614009 |
| 13 | Ribosome_Homo sapiens_hsa03010 | 2.63590610 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.50948893 |
| 15 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.45316434 |
| 16 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.44729726 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.41658736 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.98997350 |
| 19 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.92239736 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.91635540 |
| 21 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.71326606 |
| 22 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.63644530 |
| 23 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.60686785 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.37252587 |
| 25 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.36295917 |
| 26 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.29445957 |
| 27 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.26112141 |
| 28 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.24001580 |
| 29 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.23417429 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.22801351 |
| 31 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.16806249 |
| 32 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.11488866 |
| 33 | Alzheimers disease_Homo sapiens_hsa05010 | 1.03228970 |
| 34 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.02685333 |
| 35 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.02506049 |
| 36 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.97623660 |
| 37 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.96677044 |
| 38 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.95930106 |
| 39 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.91514563 |
| 40 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.90538927 |
| 41 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.88052338 |
| 42 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.86585992 |
| 43 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.86505617 |
| 44 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.86473138 |
| 45 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.83988170 |
| 46 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.82267272 |
| 47 | HTLV-I infection_Homo sapiens_hsa05166 | 0.79266839 |
| 48 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.78215373 |
| 49 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.76583846 |
| 50 | Legionellosis_Homo sapiens_hsa05134 | 0.65715926 |
| 51 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.64886899 |
| 52 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.59528998 |
| 53 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.57893576 |
| 54 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.57092747 |
| 55 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.54707909 |
| 56 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.54129422 |
| 57 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.53124834 |
| 58 | Measles_Homo sapiens_hsa05162 | 0.52905738 |
| 59 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.51420573 |
| 60 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.51260595 |
| 61 | Protein export_Homo sapiens_hsa03060 | 0.49082295 |
| 62 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.48605700 |
| 63 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.48382551 |
| 64 | Apoptosis_Homo sapiens_hsa04210 | 0.48316547 |
| 65 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.47260066 |
| 66 | Carbon metabolism_Homo sapiens_hsa01200 | 0.43993054 |
| 67 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.43374706 |
| 68 | Thyroid cancer_Homo sapiens_hsa05216 | 0.42078158 |
| 69 | Hepatitis B_Homo sapiens_hsa05161 | 0.38219974 |
| 70 | Alcoholism_Homo sapiens_hsa05034 | 0.35944028 |
| 71 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.35866717 |
| 72 | Huntingtons disease_Homo sapiens_hsa05016 | 0.35646296 |
| 73 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.34577724 |
| 74 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.34459605 |
| 75 | Colorectal cancer_Homo sapiens_hsa05210 | 0.32994348 |
| 76 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.32813358 |
| 77 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.32548339 |
| 78 | Shigellosis_Homo sapiens_hsa05131 | 0.32210967 |
| 79 | Influenza A_Homo sapiens_hsa05164 | 0.31809384 |
| 80 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.31668404 |
| 81 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.30522230 |
| 82 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.30280566 |
| 83 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.30030081 |
| 84 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.30020405 |
| 85 | Viral myocarditis_Homo sapiens_hsa05416 | 0.29454021 |
| 86 | Allograft rejection_Homo sapiens_hsa05330 | 0.29118319 |
| 87 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.28860254 |
| 88 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.28070359 |
| 89 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.27154601 |
| 90 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.26142956 |
| 91 | Peroxisome_Homo sapiens_hsa04146 | 0.25442327 |
| 92 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.25024963 |
| 93 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.24667572 |
| 94 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.24321831 |
| 95 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.23969085 |
| 96 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.23034689 |
| 97 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.20801546 |
| 98 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.18787298 |
| 99 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.18701739 |
| 100 | Galactose metabolism_Homo sapiens_hsa00052 | 0.18524752 |
| 101 | Sulfur relay system_Homo sapiens_hsa04122 | 0.18416662 |
| 102 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.18123298 |
| 103 | Pathways in cancer_Homo sapiens_hsa05200 | 0.17682585 |
| 104 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.17411960 |
| 105 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.17387786 |
| 106 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.17170831 |
| 107 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.16755464 |
| 108 | Lysine degradation_Homo sapiens_hsa00310 | 0.15986277 |
| 109 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.15555782 |
| 110 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.15073991 |
| 111 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.15014046 |
| 112 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.14240314 |
| 113 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.14062545 |
| 114 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.13457289 |
| 115 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.13120492 |
| 116 | Metabolic pathways_Homo sapiens_hsa01100 | 0.13077746 |
| 117 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.12857685 |
| 118 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.12747039 |
| 119 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.10810526 |
| 120 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.10508484 |
| 121 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.09652792 |
| 122 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.09294277 |
| 123 | Parkinsons disease_Homo sapiens_hsa05012 | 0.08750181 |
| 124 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.08570478 |
| 125 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.01852777 |
| 126 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.01109742 |
| 127 | Prostate cancer_Homo sapiens_hsa05215 | -0.0207861 |
| 128 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | -0.0074747 |
| 129 | Arginine biosynthesis_Homo sapiens_hsa00220 | -0.0074580 |

