HSPA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.71123513
2cilium movement (GO:0003341)9.63244049
3acrosome assembly (GO:0001675)9.59824545
4acrosome reaction (GO:0007340)9.44957197
5sperm-egg recognition (GO:0035036)9.34637732
6multicellular organism reproduction (GO:0032504)9.32516855
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.25297404
8* male meiosis (GO:0007140)9.20336331
9plasma membrane fusion (GO:0045026)9.17056248
10synaptonemal complex assembly (GO:0007130)8.77049477
11binding of sperm to zona pellucida (GO:0007339)8.64772867
12* spermatid development (GO:0007286)8.43941610
13* synaptonemal complex organization (GO:0070193)8.33832809
14cell-cell recognition (GO:0009988)8.32017688
15DNA methylation involved in gamete generation (GO:0043046)8.11563122
16regulation of cilium movement (GO:0003352)7.81294472
17reproduction (GO:0000003)7.53587830
18axon ensheathment in central nervous system (GO:0032291)7.27750180
19central nervous system myelination (GO:0022010)7.27750180
20cell wall macromolecule catabolic process (GO:0016998)7.21731943
21cell wall macromolecule metabolic process (GO:0044036)7.21731943
22single fertilization (GO:0007338)6.62966818
23ventricular system development (GO:0021591)6.24022358
24fertilization (GO:0009566)6.10986723
25chromosome organization involved in meiosis (GO:0070192)6.03970752
26* male meiosis I (GO:0007141)5.93158740
27spermatogenesis (GO:0007283)5.71993368
28male gamete generation (GO:0048232)5.69756685
29sperm capacitation (GO:0048240)5.65435021
30* meiotic nuclear division (GO:0007126)5.56705621
31synaptic vesicle docking involved in exocytosis (GO:0016081)5.40207298
32axoneme assembly (GO:0035082)5.37549695
33sodium ion export (GO:0071436)5.37528673
34cellular potassium ion homeostasis (GO:0030007)5.35015457
35gamete generation (GO:0007276)5.25395295
36protein localization to cilium (GO:0061512)5.25114047
37meiotic cell cycle (GO:0051321)5.23842287
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.19381294
39regulation of meiosis I (GO:0060631)5.18895566
40intraciliary transport (GO:0042073)5.13379593
41* germ cell development (GO:0007281)5.06007466
42* cellular process involved in reproduction in multicellular organism (GO:0022412)4.99391782
43left/right pattern formation (GO:0060972)4.78784229
44glutamate secretion (GO:0014047)4.73786939
45* meiosis I (GO:0007127)4.71952352
46regulation of microtubule-based movement (GO:0060632)4.71508090
47synaptic vesicle maturation (GO:0016188)4.57249884
48neuronal action potential propagation (GO:0019227)4.56789970
49sarcoplasmic reticulum calcium ion transport (GO:0070296)4.54708948
50calcium ion-dependent exocytosis (GO:0017156)4.47403564
51organic cation transport (GO:0015695)4.41831484
52regulation of short-term neuronal synaptic plasticity (GO:0048172)4.37022752
53genitalia morphogenesis (GO:0035112)4.30002967
54seminiferous tubule development (GO:0072520)4.29974907
55microtubule severing (GO:0051013)4.26830759
56microtubule depolymerization (GO:0007019)4.24605490
57potassium ion import (GO:0010107)4.22646944
58gene silencing by RNA (GO:0031047)4.20945145
59cell recognition (GO:0008037)4.12892724
60positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.12801074
61multicellular organismal reproductive process (GO:0048609)4.12102043
62L-amino acid import (GO:0043092)4.11456825
63* negative regulation of inclusion body assembly (GO:0090084)4.11439688
64muscle filament sliding (GO:0030049)4.06755565
65actin-myosin filament sliding (GO:0033275)4.06755565
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.02145288
67protein polyglutamylation (GO:0018095)3.87503415
68potassium ion homeostasis (GO:0055075)3.84916195
69cilium organization (GO:0044782)3.80253604
70synaptic vesicle exocytosis (GO:0016079)3.80053070
71amino acid import (GO:0043090)3.79660297
72microtubule-based movement (GO:0007018)3.77007895
73* regulation of inclusion body assembly (GO:0090083)3.76750037
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.76436151
75cell communication by electrical coupling (GO:0010644)3.75249567
76postsynaptic membrane organization (GO:0001941)3.68767966
77regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.66605067
78regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.62610543
79regulation of synaptic vesicle exocytosis (GO:2000300)3.61653894
80cilium assembly (GO:0042384)3.58047004
81neuronal ion channel clustering (GO:0045161)3.54634068
82regulation of skeletal muscle contraction (GO:0014819)3.51089472
83cilium morphogenesis (GO:0060271)3.49337825
84regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.48722861
85neurotransmitter uptake (GO:0001504)3.47910499
86cytoskeletal anchoring at plasma membrane (GO:0007016)3.44751597
87synapsis (GO:0007129)3.43469031
88positive regulation of synapse maturation (GO:0090129)3.43379245
89actin-mediated cell contraction (GO:0070252)3.40716128
90regulation of cell communication by electrical coupling (GO:0010649)3.40596077
91cellular component assembly involved in morphogenesis (GO:0010927)3.40333675
92regulation of synaptic vesicle transport (GO:1902803)3.40013480
93* meiotic cell cycle process (GO:1903046)3.39232432
94cerebellar granule cell differentiation (GO:0021707)3.38803122
95spermatid nucleus differentiation (GO:0007289)3.38393377
96regulation of neuronal synaptic plasticity (GO:0048168)3.38290160
97neurotransmitter secretion (GO:0007269)3.38019930
98myelin maintenance (GO:0043217)3.33492325
99negative regulation of synaptic transmission, GABAergic (GO:0032229)3.32121448
100left/right axis specification (GO:0070986)3.31037836
101monoubiquitinated protein deubiquitination (GO:0035520)3.30295353
102multicellular organismal development (GO:0007275)3.25324260
103ensheathment of neurons (GO:0007272)3.24853907
104axon ensheathment (GO:0008366)3.24853907
105myelination (GO:0042552)3.23260147
106regulation of protein polyubiquitination (GO:1902914)3.19765853
107negative regulation of organelle assembly (GO:1902116)3.19672103
108striated muscle contraction (GO:0006941)3.18073908
109chaperone-mediated protein complex assembly (GO:0051131)3.17946878
110skeletal muscle contraction (GO:0003009)3.17348067
111positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15369870
112nucleoside diphosphate phosphorylation (GO:0006165)3.14951084
113neuromuscular synaptic transmission (GO:0007274)3.14841934
114relaxation of muscle (GO:0090075)3.14482555
115long-chain fatty acid biosynthetic process (GO:0042759)3.13167436
116cellular sodium ion homeostasis (GO:0006883)3.09572704
117centriole replication (GO:0007099)3.08877777
118lactate metabolic process (GO:0006089)3.07907540
119myofibril assembly (GO:0030239)3.03557099
120regulation of relaxation of muscle (GO:1901077)3.03090401
121membrane depolarization during action potential (GO:0086010)3.01072231
122skeletal muscle fiber development (GO:0048741)2.98834250
123positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.98827530
124presynaptic membrane organization (GO:0097090)2.98041474
125centriole assembly (GO:0098534)2.97586794
126plasma membrane repair (GO:0001778)2.97339869
127acidic amino acid transport (GO:0015800)2.95934575
128regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.91470296
129DNA methylation (GO:0006306)2.91134173
130DNA alkylation (GO:0006305)2.91134173
131sex differentiation (GO:0007548)2.89589843
132regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.88680457
133vocalization behavior (GO:0071625)2.88287648
134cell communication involved in cardiac conduction (GO:0086065)2.87582617
135locomotory exploration behavior (GO:0035641)2.86630499
136substantia nigra development (GO:0021762)2.85188973
137regulation of synapse maturation (GO:0090128)2.84161836
138gamma-aminobutyric acid signaling pathway (GO:0007214)2.84008586
139gamma-aminobutyric acid transport (GO:0015812)2.83971413
140positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.83677814
141neurotransmitter transport (GO:0006836)2.82948161
142nuclear pore complex assembly (GO:0051292)2.81987186
143creatine metabolic process (GO:0006600)2.81578261
144regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.81160456
145regulation of long-term neuronal synaptic plasticity (GO:0048169)2.81016363
146cardiac muscle contraction (GO:0060048)2.80087741
147regulation of actin filament-based movement (GO:1903115)2.79271519
148carnitine transmembrane transport (GO:1902603)2.78872539
149microtubule bundle formation (GO:0001578)2.78442673
150astrocyte development (GO:0014002)2.77245713
151regulation of neurotransmitter levels (GO:0001505)2.77015788
152carnitine transport (GO:0015879)2.75745314
153amino-acid betaine transport (GO:0015838)2.75745314
154ionotropic glutamate receptor signaling pathway (GO:0035235)2.73806469
155regulation of centriole replication (GO:0046599)2.72153470
156neuromuscular process controlling balance (GO:0050885)2.72067584
157L-glutamate transport (GO:0015813)2.71351246
158GTP biosynthetic process (GO:0006183)2.70853064
159regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.68980332
160negative regulation of skeletal muscle tissue development (GO:0048642)2.68901594
161gene silencing (GO:0016458)2.68582073
162cGMP-mediated signaling (GO:0019934)2.68534462
163myotube cell development (GO:0014904)2.68397214
164relaxation of cardiac muscle (GO:0055119)2.68269678
165glycerol ether metabolic process (GO:0006662)2.66732974
166positive regulation of potassium ion transport (GO:0043268)2.66416564
167polyol catabolic process (GO:0046174)2.66315102
168muscle contraction (GO:0006936)2.66028044
169regulation of membrane repolarization (GO:0060306)2.65958005
170positive regulation of dendritic spine development (GO:0060999)2.65448479
171myelination in peripheral nervous system (GO:0022011)2.65389483
172peripheral nervous system axon ensheathment (GO:0032292)2.65389483
173relaxation of smooth muscle (GO:0044557)2.65293005
174regulation of synaptic plasticity (GO:0048167)2.63803146
175synaptic transmission, glutamatergic (GO:0035249)2.62852757
176presynaptic membrane assembly (GO:0097105)2.61714421
177regulation of voltage-gated calcium channel activity (GO:1901385)2.59994065
178actin filament-based movement (GO:0030048)2.59642046
179regulation of calcium ion transmembrane transporter activity (GO:1901019)2.59413639
180regulation of calcium ion transmembrane transport (GO:1903169)2.59413639
181regulation of sodium ion transmembrane transport (GO:1902305)2.59231575
182peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.58967346
183negative regulation of DNA repair (GO:0045738)2.58757601
184positive regulation of meiosis (GO:0045836)2.58750471
185regulation of response to osmotic stress (GO:0047484)2.58464735
186regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.58302208
187regulation of spindle checkpoint (GO:0090231)2.57013272
188alditol metabolic process (GO:0019400)2.53813174
189nucleus organization (GO:0006997)2.52223615
190positive regulation of meiotic cell cycle (GO:0051446)2.50554425
191protein K11-linked deubiquitination (GO:0035871)2.49781943
192cellular response to gamma radiation (GO:0071480)2.49470355
193microtubule polymerization or depolymerization (GO:0031109)2.46835821
194ether metabolic process (GO:0018904)2.45937106
195cilium or flagellum-dependent cell motility (GO:0001539)15.8930966
196piRNA metabolic process (GO:0034587)12.3577993
197fusion of sperm to egg plasma membrane (GO:0007342)12.0025552
198axonemal dynein complex assembly (GO:0070286)11.9924879
199sperm motility (GO:0030317)11.0270946
200epithelial cilium movement (GO:0003351)10.0624658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.81593178
2EZH2_22144423_ChIP-Seq_EOC_Human5.87779436
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.26736509
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.23143348
5DROSHA_22980978_ChIP-Seq_HELA_Human2.59576986
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59296459
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51525481
8* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38184998
9* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31089293
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26593638
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25091944
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25091944
13* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23422587
14GBX2_23144817_ChIP-Seq_PC3_Human2.19557952
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.17704850
16* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13122172
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11801290
18ZNF274_21170338_ChIP-Seq_K562_Hela2.11455722
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.11002946
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07835652
21* EZH2_27304074_Chip-Seq_ESCs_Mouse2.05868149
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.04739066
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03187453
24* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02271806
25GATA1_26923725_Chip-Seq_HPCs_Mouse2.01827622
26VDR_22108803_ChIP-Seq_LS180_Human1.99691057
27* RARB_27405468_Chip-Seq_BRAIN_Mouse1.96902741
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96100193
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.93037024
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.89734400
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87755814
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86351505
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85865382
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83966249
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80059227
36* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.78387062
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77582466
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.76839081
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73561276
40ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69672193
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67698222
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.63673033
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57889703
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.56136652
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.53516534
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53134129
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51478738
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51441355
49TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.50350479
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.46506877
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46240089
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.45292855
53REST_21632747_ChIP-Seq_MESCs_Mouse1.44957739
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43359823
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42732575
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.41772498
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.40108367
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39057488
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38532910
60CBP_20019798_ChIP-Seq_JUKART_Human1.37696663
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37696663
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36173848
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35926337
64CTCF_27219007_Chip-Seq_Bcells_Human1.35684946
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35531697
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34574361
67RNF2_27304074_Chip-Seq_NSC_Mouse1.33503459
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33169418
69AR_21572438_ChIP-Seq_LNCaP_Human1.32746794
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29413552
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27987476
72* CBX2_27304074_Chip-Seq_ESCs_Mouse1.27450476
73STAT1_17558387_ChIP-Seq_HELA_Human1.27379737
74KDM2B_26808549_Chip-Seq_REH_Human1.27191600
75* RING1B_27294783_Chip-Seq_ESCs_Mouse1.27124420
76KDM2B_26808549_Chip-Seq_K562_Human1.26501083
77BCAT_22108803_ChIP-Seq_LS180_Human1.25909118
78GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.25769705
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24718947
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.24158772
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24118475
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24118475
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20450404
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20394631
85TET1_21490601_ChIP-Seq_MESCs_Mouse1.19325416
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19286190
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18700919
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17424726
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.17275076
90TCF4_23295773_ChIP-Seq_U87_Human1.15549300
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15490359
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15204771
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14446542
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14302536
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14146349
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14120135
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13776470
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12412836
99ER_23166858_ChIP-Seq_MCF-7_Human1.12243214
100RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12009475
101FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11259477
102PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10223867
103SMAD4_21799915_ChIP-Seq_A2780_Human1.10070611
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.09766375
105SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09451612
106P53_22387025_ChIP-Seq_ESCs_Mouse1.09245505
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.08794011
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08554579
109RING1B_27294783_Chip-Seq_NPCs_Mouse1.08544437
110SOX2_22085726_ChIP-Seq_NPCs_Mouse1.08357105
111OCT4_18555785_Chip-Seq_ESCs_Mouse1.08243633
112TAF15_26573619_Chip-Seq_HEK293_Human1.07193969
113STAT3_18555785_Chip-Seq_ESCs_Mouse1.06922841
114P300_18555785_Chip-Seq_ESCs_Mouse1.06892459
115KAP1_22055183_ChIP-Seq_ESCs_Mouse1.06889969
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05680687
117RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05388732
118SMAD4_21741376_ChIP-Seq_EPCs_Human1.05340580
119* AR_19668381_ChIP-Seq_PC3_Human1.03810322
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03623859
121GF1_26923725_Chip-Seq_HPCs_Mouse1.03205402
122SOX2_21211035_ChIP-Seq_LN229_Gbm1.03039421
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02870599
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.02802089
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02260222
126SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.01979666
127CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00912890
128TBL1_22424771_ChIP-Seq_293T_Human1.00868290
129KLF4_18555785_Chip-Seq_ESCs_Mouse1.00774095
130CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00387174
131TBX20_22328084_ChIP-Seq_HEART_Mouse0.99787068
132TBX20_22080862_ChIP-Seq_HEART_Mouse0.99787068
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99593666
134OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99572479
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99555698
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.99495648
137* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98294033
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98221083
139GATA3_21867929_ChIP-Seq_CD8_Mouse0.97125535
140FUS_26573619_Chip-Seq_HEK293_Human0.97100441
141ESR1_20079471_ChIP-ChIP_T-47D_Human0.96977819
142ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96069896
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.94941345
144TP53_23651856_ChIP-Seq_MEFs_Mouse0.94649385
145SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94588479
146ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94557323
147RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94448196
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94261429
149LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.94157462
150* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94045950
151CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93917160
152YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93483866
153E2F1_18555785_Chip-Seq_ESCs_Mouse0.93113538
154* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91886628
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91638589
156EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91606401
157PU1_27457419_Chip-Seq_LIVER_Mouse0.91472893
158NFYB_21822215_ChIP-Seq_K562_Human0.91390606
159CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90485395
160NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90395226
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.89954824
162P53_21459846_ChIP-Seq_SAOS-2_Human0.89937170
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.89399877
164RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89046666
165GATA3_21867929_ChIP-Seq_TH1_Mouse0.89030822
166SOX2_18555785_Chip-Seq_ESCs_Mouse0.88173734
167SOX9_26525672_Chip-Seq_HEART_Mouse0.87004029
168* TP53_20018659_ChIP-ChIP_R1E_Mouse0.86789356
169P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86574874
170NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86555335
171GF1B_26923725_Chip-Seq_HPCs_Mouse0.85953300
172STAT3_23295773_ChIP-Seq_U87_Human0.85397370
173SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85322843
174SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85065080
175* OCT4_19829295_ChIP-Seq_ESCs_Human0.79234708
176PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.77424299
177OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75675059
178LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75337824
179LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75302480
180SMC4_20622854_ChIP-Seq_HELA_Human0.74951667

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.41183082
2* MP0003698_abnormal_male_reproductive5.51007364
3* MP0001929_abnormal_gametogenesis5.09899404
4* MP0002210_abnormal_sex_determination3.79244019
5MP0004145_abnormal_muscle_electrophysio3.47188266
6MP0002653_abnormal_ependyma_morphology3.41914858
7* MP0001145_abnormal_male_reproductive3.07869807
8* MP0002161_abnormal_fertility/fecundity2.94418151
9MP0000749_muscle_degeneration2.85741028
10* MP0000653_abnormal_sex_gland2.69222877
11MP0008057_abnormal_DNA_replication2.46660033
12MP0005623_abnormal_meninges_morphology2.46051624
13MP0000747_muscle_weakness2.16587209
14MP0002160_abnormal_reproductive_system2.14547029
15MP0005410_abnormal_fertilization13.3169352
16MP0001984_abnormal_olfaction1.78876813
17MP0000759_abnormal_skeletal_muscle1.63865306
18MP0004087_abnormal_muscle_fiber1.59439562
19MP0004130_abnormal_muscle_cell1.58197823
20MP0009046_muscle_twitch1.58013977
21MP0005377_hearing/vestibular/ear_phenot1.54527436
22MP0003878_abnormal_ear_physiology1.54527436
23MP0005620_abnormal_muscle_contractility1.50619414
24MP0001299_abnormal_eye_distance/1.50416451
25MP0002106_abnormal_muscle_physiology1.50290946
26MP0002269_muscular_atrophy1.49642547
27MP0000579_abnormal_nail_morphology1.47244262
28MP0005369_muscle_phenotype1.44711400
29MP0008995_early_reproductive_senescence1.43998417
30MP0002735_abnormal_chemical_nociception1.41959364
31MP0001501_abnormal_sleep_pattern1.37592252
32MP0004134_abnormal_chest_morphology1.34246759
33MP0005171_absent_coat_pigmentation1.32940263
34MP0004215_abnormal_myocardial_fiber1.32571292
35MP0002282_abnormal_trachea_morphology1.31441316
36MP0005670_abnormal_white_adipose1.30179928
37MP0001970_abnormal_pain_threshold1.27485814
38MP0000013_abnormal_adipose_tissue1.27403182
39MP0004084_abnormal_cardiac_muscle1.25598404
40MP0003646_muscle_fatigue1.23483659
41MP0004270_analgesia1.22365183
42MP0002332_abnormal_exercise_endurance1.20118984
43MP0001529_abnormal_vocalization1.18963145
44MP0000750_abnormal_muscle_regeneration1.18420382
45MP0002066_abnormal_motor_capabilities/c1.18225672
46MP0002733_abnormal_thermal_nociception1.12606001
47MP0003786_premature_aging1.11536339
48MP0005647_abnormal_sex_gland1.10625423
49MP0005389_reproductive_system_phenotype1.08498114
50MP0005386_behavior/neurological_phenoty1.06459395
51MP0004924_abnormal_behavior1.06459395
52MP0003329_amyloid_beta_deposits0.99756036
53MP0003137_abnormal_impulse_conducting0.97348213
54MP0002972_abnormal_cardiac_muscle0.95476544
55MP0000733_abnormal_muscle_development0.95332582
56MP0005330_cardiomyopathy0.93646159
57MP0001346_abnormal_lacrimal_gland0.93557938
58MP0001958_emphysema0.91987679
59MP0006276_abnormal_autonomic_nervous0.91598170
60MP0004233_abnormal_muscle_weight0.90812404
61MP0005167_abnormal_blood-brain_barrier0.90630678
62MP0001765_abnormal_ion_homeostasis0.90580914
63MP0003136_yellow_coat_color0.89229433
64MP0004484_altered_response_of0.88983697
65MP0008007_abnormal_cellular_replicative0.87903149
66MP0001177_atelectasis0.86072565
67MP0005646_abnormal_pituitary_gland0.83790261
68MP0003950_abnormal_plasma_membrane0.82545388
69MP0004742_abnormal_vestibular_system0.81642204
70MP0000678_abnormal_parathyroid_gland0.81583919
71MP0003705_abnormal_hypodermis_morpholog0.80794858
72MP0010030_abnormal_orbit_morphology0.78629043
73MP0000762_abnormal_tongue_morphology0.76731408
74MP0001440_abnormal_grooming_behavior0.76469161
75MP0005275_abnormal_skin_tensile0.76459303
76MP0003879_abnormal_hair_cell0.75310781
77MP0004085_abnormal_heartbeat0.74604655
78MP0003880_abnormal_central_pattern0.73263103
79MP0004859_abnormal_synaptic_plasticity0.71570755
80MP0004142_abnormal_muscle_tone0.71123153
81MP0000003_abnormal_adipose_tissue0.70730882
82MP0003634_abnormal_glial_cell0.68850673
83MP0002184_abnormal_innervation0.68801590
84MP0003690_abnormal_glial_cell0.68711640
85MP0004885_abnormal_endolymph0.68074812
86MP0002928_abnormal_bile_duct0.67247378
87MP0008438_abnormal_cutaneous_collagen0.66241972
88MP0000566_synostosis0.65723778
89MP0002272_abnormal_nervous_system0.65345381
90MP0008058_abnormal_DNA_repair0.64292751
91MP0000920_abnormal_myelination0.63586596
92MP0003115_abnormal_respiratory_system0.63434689
93MP0001851_eye_inflammation0.62472475
94MP0002572_abnormal_emotion/affect_behav0.62101274
95MP0005551_abnormal_eye_electrophysiolog0.60837836
96MP0000778_abnormal_nervous_system0.60577411
97MP0000427_abnormal_hair_cycle0.60373898
98MP0003635_abnormal_synaptic_transmissio0.58670419
99MP0009745_abnormal_behavioral_response0.57886898
100MP0001486_abnormal_startle_reflex0.57667411
101MP0003045_fibrosis0.56195512
102MP0005253_abnormal_eye_physiology0.55143378
103MP0003633_abnormal_nervous_system0.54604021
104MP0000647_abnormal_sebaceous_gland0.52200925
105MP0002063_abnormal_learning/memory/cond0.51606318
106MP0003011_delayed_dark_adaptation0.51475003
107MP0003631_nervous_system_phenotype0.51268099
108MP0001963_abnormal_hearing_physiology0.50997866
109MP0002152_abnormal_brain_morphology0.50694309
110MP0003699_abnormal_female_reproductive0.50593760
111MP0002064_seizures0.49511723
112MP0002736_abnormal_nociception_after0.48781157
113MP0002734_abnormal_mechanical_nocicepti0.48616280
114MP0001905_abnormal_dopamine_level0.48397964
115MP0002295_abnormal_pulmonary_circulatio0.48153617
116MP0002229_neurodegeneration0.47204302
117MP0001485_abnormal_pinna_reflex0.46971434
118MP0010094_abnormal_chromosome_stability0.46955005
119MP0000955_abnormal_spinal_cord0.46870889
120MP0001986_abnormal_taste_sensitivity0.45646172
121MP0004811_abnormal_neuron_physiology0.45424931
122MP0003861_abnormal_nervous_system0.42991497
123MP0005423_abnormal_somatic_nervous0.42770716
124MP0004808_abnormal_hematopoietic_stem0.41252828
125MP0001119_abnormal_female_reproductive0.40527796
126MP0003632_abnormal_nervous_system0.40413450
127MP0002234_abnormal_pharynx_morphology0.40379651
128MP0000751_myopathy0.40310733
129MP0004133_heterotaxia0.40274935
130MP0002882_abnormal_neuron_morphology0.40259647
131MP0005391_vision/eye_phenotype0.39668804
132MP0008569_lethality_at_weaning0.39445363
133MP0001968_abnormal_touch/_nociception0.39130250
134MP0001727_abnormal_embryo_implantation0.39029660
135MP0002108_abnormal_muscle_morphology0.38883883
136MP0001502_abnormal_circadian_rhythm0.38847052
137MP0000534_abnormal_ureter_morphology0.37209334
138MP0002067_abnormal_sensory_capabilities0.36849221
139MP0002557_abnormal_social/conspecific_i0.36300124
140MP0003942_abnormal_urinary_system0.35708786
141MP0000026_abnormal_inner_ear0.35366488
142MP0004036_abnormal_muscle_relaxation0.34844157
143MP0009780_abnormal_chondrocyte_physiolo0.34361853
144MP0004043_abnormal_pH_regulation0.33397412
145MP0006072_abnormal_retinal_apoptosis0.33011600
146MP0001661_extended_life_span0.32222071
147MP0002133_abnormal_respiratory_system0.32207772

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.59215563
2Abnormal respiratory epithelium morphology (HP:0012253)8.69032585
3Abnormal respiratory motile cilium morphology (HP:0005938)8.69032585
4Rhinitis (HP:0012384)8.42941625
5Abnormal ciliary motility (HP:0012262)7.88364863
6Chronic bronchitis (HP:0004469)6.93782490
7Nemaline bodies (HP:0003798)6.87791555
8Muscle fiber inclusion bodies (HP:0100299)6.82059409
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.62909187
10Type 1 muscle fiber predominance (HP:0003803)5.77184350
11Infertility (HP:0000789)5.67175478
12Nasal polyposis (HP:0100582)5.53914945
13Exercise-induced myalgia (HP:0003738)4.74019471
14Nephronophthisis (HP:0000090)4.70990445
15Bronchiectasis (HP:0002110)4.69547326
16Exercise-induced muscle cramps (HP:0003710)4.69146343
17Abnormality of the nasal mucosa (HP:0000433)4.47494644
18Bronchitis (HP:0012387)4.06297978
19Hyporeflexia of lower limbs (HP:0002600)4.04221440
20Abnormality of the lower motor neuron (HP:0002366)3.96738333
21Muscle fiber splitting (HP:0003555)3.74432106
22Abnormality of the renal medulla (HP:0100957)3.60354592
23EMG: myopathic abnormalities (HP:0003458)3.57824249
24Myokymia (HP:0002411)3.53640296
25Focal motor seizures (HP:0011153)3.52826563
26Myopathic facies (HP:0002058)3.51063798
27Bundle branch block (HP:0011710)3.42511322
28Fibular hypoplasia (HP:0003038)3.40990556
29Distal arthrogryposis (HP:0005684)3.40466541
30Gonadotropin excess (HP:0000837)3.33344183
31Male infertility (HP:0003251)3.32869469
32Muscle hypertrophy of the lower extremities (HP:0008968)3.32712106
33Tubulointerstitial nephritis (HP:0001970)3.30090536
34Febrile seizures (HP:0002373)3.29380378
35Round ear (HP:0100830)3.15195389
36Amyotrophic lateral sclerosis (HP:0007354)3.01430437
37Neck muscle weakness (HP:0000467)3.00274637
38Recurrent otitis media (HP:0000403)2.99133355
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.97840578
40Medial flaring of the eyebrow (HP:0010747)2.96366589
41Action tremor (HP:0002345)2.94242128
42Molar tooth sign on MRI (HP:0002419)2.91597934
43Abnormality of midbrain morphology (HP:0002418)2.91597934
44Focal seizures (HP:0007359)2.91134820
45Ankle clonus (HP:0011448)2.89004011
46Calf muscle hypertrophy (HP:0008981)2.86819294
47Recurrent sinusitis (HP:0011108)2.84420486
48Increased circulating renin level (HP:0000848)2.78259577
49Abnormality of binocular vision (HP:0011514)2.77185504
50Diplopia (HP:0000651)2.77185504
51Stridor (HP:0010307)2.75512860
52Atonic seizures (HP:0010819)2.74879829
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.74311951
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.74311951
55Abnormal spermatogenesis (HP:0008669)2.69693313
56Abnormality of the calf musculature (HP:0001430)2.69394507
57Tubular atrophy (HP:0000092)2.64885687
58Difficulty running (HP:0009046)2.64731731
59Abnormality of the corticospinal tract (HP:0002492)2.63922396
60Distal lower limb muscle weakness (HP:0009053)2.62691116
61Abnormality of skeletal muscle fiber size (HP:0012084)2.61356927
62Scanning speech (HP:0002168)2.61321733
63Tubulointerstitial abnormality (HP:0001969)2.54919743
64Myotonia (HP:0002486)2.52429769
65Spastic gait (HP:0002064)2.52309653
66Supranuclear gaze palsy (HP:0000605)2.49760089
67Abnormality of dentin (HP:0010299)2.46483838
68Postaxial foot polydactyly (HP:0001830)2.45605078
69Frequent falls (HP:0002359)2.44359622
70Rhabdomyolysis (HP:0003201)2.42644362
71Impaired proprioception (HP:0010831)2.42287282
7211 pairs of ribs (HP:0000878)2.41195003
73Lower limb amyotrophy (HP:0007210)2.40471095
74Generalized tonic-clonic seizures (HP:0002069)2.39524036
75Ulnar deviation of the wrist (HP:0003049)2.39311999
76Increased variability in muscle fiber diameter (HP:0003557)2.39040958
77Muscle stiffness (HP:0003552)2.38945889
78Heart block (HP:0012722)2.38909185
79Sudden death (HP:0001699)2.35681384
80Azoospermia (HP:0000027)2.31851274
81Abnormal atrioventricular conduction (HP:0005150)2.30585842
82Calcaneovalgus deformity (HP:0001848)2.29881734
83Areflexia of lower limbs (HP:0002522)2.29782386
84Dysmetria (HP:0001310)2.29606075
85Stage 5 chronic kidney disease (HP:0003774)2.28236244
86Myoglobinuria (HP:0002913)2.28135979
87Rimmed vacuoles (HP:0003805)2.26575519
88Hyperphosphatemia (HP:0002905)2.26268657
89Cerebral hypomyelination (HP:0006808)2.25509389
90Increased connective tissue (HP:0009025)2.25255467
91EMG: neuropathic changes (HP:0003445)2.23329932
92Aplasia/Hypoplasia of the fibula (HP:0006492)2.23312101
93Split foot (HP:0001839)2.21839560
94Aplasia involving bones of the extremities (HP:0009825)2.19013066
95Aplasia involving bones of the upper limbs (HP:0009823)2.19013066
96Aplasia of the phalanges of the hand (HP:0009802)2.19013066
97Epileptic encephalopathy (HP:0200134)2.17261902
98Median cleft lip (HP:0000161)2.15858738
99Recurrent bronchitis (HP:0002837)2.14641636
100Fetal akinesia sequence (HP:0001989)2.14462625
101Subaortic stenosis (HP:0001682)2.14053854
102Abnormality of the left ventricular outflow tract (HP:0011103)2.14053854
103Lower limb muscle weakness (HP:0007340)2.13787159
104Postural instability (HP:0002172)2.13709703
105Congenital hepatic fibrosis (HP:0002612)2.12536629
106Chronic sinusitis (HP:0011109)2.11891179
107Absent phalangeal crease (HP:0006109)2.11335755
108Absence seizures (HP:0002121)2.11286962
109Mildly elevated creatine phosphokinase (HP:0008180)2.10778293
110Polydipsia (HP:0001959)2.10356901
111Abnormal drinking behavior (HP:0030082)2.10356901
112Peripheral hypomyelination (HP:0007182)2.09478055
113Scapular winging (HP:0003691)2.08619409
114Upper motor neuron abnormality (HP:0002127)2.06507383
115Abnormality of permanent molar morphology (HP:0011071)2.06310248
116Abnormality of the dental root (HP:0006486)2.06310248
117Taurodontia (HP:0000679)2.06310248
118Spinal rigidity (HP:0003306)2.04729133
119Supernumerary spleens (HP:0009799)2.04417610
120Urinary bladder sphincter dysfunction (HP:0002839)2.02515151
121Foot dorsiflexor weakness (HP:0009027)2.01146994
122Degeneration of anterior horn cells (HP:0002398)2.00276724
123Abnormality of the anterior horn cell (HP:0006802)2.00276724
124Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0319312
125Absent/shortened dynein arms (HP:0200106)11.4873209
126Dynein arm defect of respiratory motile cilia (HP:0012255)11.4873209
127Oculomotor apraxia (HP:0000657)1.99746102
128Urinary urgency (HP:0000012)1.99515951
129Abnormal eating behavior (HP:0100738)1.98737291
130Short ribs (HP:0000773)1.98195585
131Abnormality of the foot musculature (HP:0001436)1.97597120
132Hyperkalemia (HP:0002153)1.97278238
133Abnormality of molar morphology (HP:0011070)1.97185271
134Abnormality of molar (HP:0011077)1.97185271
135Akinesia (HP:0002304)1.93945069
136Deformed tarsal bones (HP:0008119)1.92688008
137Cerebral inclusion bodies (HP:0100314)1.92004311
138Alacrima (HP:0000522)1.91721375
139Pancreatic fibrosis (HP:0100732)1.91686691
140Bell-shaped thorax (HP:0001591)1.91624386
141Dialeptic seizures (HP:0011146)1.91529374
142Postaxial hand polydactyly (HP:0001162)1.90996735
143Obstructive sleep apnea (HP:0002870)1.90355284
144Abnormality of the dental pulp (HP:0006479)1.89276085
145Shallow orbits (HP:0000586)1.88104357
146Turricephaly (HP:0000262)1.87350228
147Congenital primary aphakia (HP:0007707)1.86992930
148Gait imbalance (HP:0002141)1.86811680
149Tubulointerstitial fibrosis (HP:0005576)1.86423314
150Slender build (HP:0001533)1.85001761
151Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84760006
152Renal dysplasia (HP:0000110)1.84688621
153Impulsivity (HP:0100710)1.84507757
154Limited hip movement (HP:0008800)1.83620621
155Distal lower limb amyotrophy (HP:0008944)1.83470070
156Hip contracture (HP:0003273)1.82767207
157True hermaphroditism (HP:0010459)1.81079794
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.80837225
159Broad distal phalanx of finger (HP:0009836)1.77999878
160Hypomagnesemia (HP:0002917)1.77983382
161Rigidity (HP:0002063)1.76356802
162Torticollis (HP:0000473)1.75756282
163Abnormality of the renal cortex (HP:0011035)1.75484104
164Hemiparesis (HP:0001269)1.74816507
165Generalized muscle weakness (HP:0003324)1.74349759
166Facial cleft (HP:0002006)1.74198122
167Intention tremor (HP:0002080)1.74054704
168Cystic liver disease (HP:0006706)1.68714034
169Nephrogenic diabetes insipidus (HP:0009806)1.65365467
170Large eyes (HP:0001090)1.63713712
171Short thorax (HP:0010306)1.63581688
172Gaze-evoked nystagmus (HP:0000640)1.61838756
173Microglossia (HP:0000171)1.60746873
174Nephropathy (HP:0000112)1.60514241
175J-shaped sella turcica (HP:0002680)1.59164355
176Aplasia/Hypoplasia of the tongue (HP:0010295)1.57872169
177Decreased motor nerve conduction velocity (HP:0003431)1.57280096
178Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57238767
179Absent epiphyses (HP:0010577)1.57238767
180Selective tooth agenesis (HP:0001592)1.54340192
181Short nail (HP:0001799)1.54218389
182Abnormality of renal excretion (HP:0011036)1.53662194
183Absent frontal sinuses (HP:0002688)1.53205820
184Aplasia/Hypoplasia of the lens (HP:0008063)1.50950096
185Genital tract atresia (HP:0001827)1.48782525
186Abnormal biliary tract physiology (HP:0012439)1.45003206
187Bile duct proliferation (HP:0001408)1.45003206
188Vaginal atresia (HP:0000148)1.44847014
189Occipital encephalocele (HP:0002085)1.44665863
190Neurofibrillary tangles (HP:0002185)1.43807669
191Poor coordination (HP:0002370)1.40462486
192Pachygyria (HP:0001302)1.37993219
193Abnormal urine output (HP:0012590)1.37795357
194Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.37533031
195Abnormality of ocular smooth pursuit (HP:0000617)1.36918922
196Spastic tetraparesis (HP:0001285)1.35521388
197Retinal dysplasia (HP:0007973)1.33785148
198Missing ribs (HP:0000921)1.33586530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.80701789
2PDK48.80701789
3PDK25.81873611
4OBSCN5.01546808
5PRKD34.11225445
6PHKG14.07619417
7PHKG24.07619417
8TESK13.96054280
9PNCK3.17194434
10ICK3.12196291
11TTN3.08608432
12STK392.70698010
13PTK2B2.68481872
14MARK12.68319106
15UHMK12.61831160
16LATS22.50635877
17WNK42.45080537
18MAPK152.07894180
19DAPK22.02122113
20RIPK11.92619029
21NTRK11.79804568
22CAMK2G1.73216668
23MAP3K91.73146326
24CAMK2B1.63950687
25MAPK121.40105781
26LIMK11.36863062
27WNK11.36416716
28FGFR21.30427073
29CAMK11.29647523
30NEK21.28800449
31DMPK1.23172116
32KSR21.17213933
33CAMK2D1.14647176
34TYRO31.09299232
35STK381.07446852
36ARAF1.06608955
37PIK3CG1.04266120
38GRK50.98658054
39MYLK0.98251684
40PAK30.91049842
41STK30.85758128
42PBK0.84857282
43ROCK20.82526306
44DYRK1A0.81241376
45PTK20.79921249
46PDK10.76776699
47LMTK20.75907364
48PRKD10.75667456
49PINK10.75471884
50MAP3K70.75391530
51PDGFRA0.72550989
52NEK60.71803372
53MAPKAPK30.70785643
54CCNB10.69886441
55SGK10.69068863
56DAPK30.68901147
57DYRK1B0.68581890
58SIK10.65005557
59CDC70.63829032
60MAP3K130.63694416
61CAMK40.63559208
62PRKCH0.61675260
63IRAK10.59831859
64NTRK20.59471945
65MAPK130.59250975
66MAP2K10.59211542
67MAP3K20.58255752
68NME10.56992777
69PASK0.56844552
70EPHA20.52632337
71SIK20.50887803
72DDR20.48579064
73MAP3K30.48189646
74TNIK0.47392487
75CAMK1G0.46962235
76BRSK10.46410261
77MOS0.44348609
78MUSK0.43856124
79WNK30.43770944
80MAP2K40.43726619
81PRKCG0.42167226
82AKT20.39782162
83PRKG20.39633713
84CHEK10.39309261
85BMX0.38789685
86BMPR1B0.38319296
87KSR10.38052050
88PIK3CA0.37250486
89EPHB10.37244564
90OXSR10.36221278
91WEE10.35121182
92ATR0.34029291
93TTK0.33395519
94DYRK30.30891441
95PAK60.30831377
96CDK30.30127331
97STK38L0.28949623
98CASK0.28140354
99EPHA40.27960703
100MAPKAPK50.27755006
101PDPK10.26907254
102PAK20.26736927
103CHEK20.26411533
104BCR0.25283886
105NTRK30.24709170
106ATM0.23455191
107PRPF4B0.22579047
108PAK10.22304914
109CAMKK10.22095245
110MAP3K40.21510941
111SGK2230.18978666
112SGK4940.18978666
113MARK20.16627819
114CAMK2A0.16307848
115PRKAA10.15972453
116MTOR0.15574084
117PLK40.15519274
118RPS6KB10.15381612
119BRAF0.14749121
120PRKCQ0.13723904
121PLK20.11882096
122SGK20.11780171
123CDK120.10744114
124MAP2K70.10132293
125PRKG10.09058464
126CDK150.08344750
127CDK180.08344610
128IRAK20.08069658
129CDK50.07868493
130BMPR20.07811023
131MINK10.06872702
132CDK140.06701027
133CSNK1D0.06151612
134PRKACB0.05989798
135GSK3B0.05597575
136FRK0.05158891
137MAPK100.04446523
138CDK11A0.04146538
139MET0.04123151
140STK110.04085669
141RPS6KA30.03009526
142AKT30.02549226
143CLK10.01654710
144PRKCZ0.01642958
145PRKDC0.01580514
146MAPK70.01026590
147PRKACA0.00929773
148SGK30.00709647
149MAPK80.00674903
150PRKCA0.00310804
151CDK10.00027996
152PRKACG-0.0045493
153ERBB3-0.0027312
154PKN1-0.0012087
155ROCK1-0.0002077

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.07652820
2Pyruvate metabolism_Homo sapiens_hsa006203.64047138
3Dorso-ventral axis formation_Homo sapiens_hsa043203.60480470
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.31214296
5Fatty acid biosynthesis_Homo sapiens_hsa000613.09525158
6Glucagon signaling pathway_Homo sapiens_hsa049222.61196892
7Propanoate metabolism_Homo sapiens_hsa006402.58908303
8Basal transcription factors_Homo sapiens_hsa030222.58381329
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27938258
10Amphetamine addiction_Homo sapiens_hsa050312.24853474
11Linoleic acid metabolism_Homo sapiens_hsa005912.15964009
12GABAergic synapse_Homo sapiens_hsa047272.10137048
13Fanconi anemia pathway_Homo sapiens_hsa034602.08034485
14Huntingtons disease_Homo sapiens_hsa050161.98377029
15Dilated cardiomyopathy_Homo sapiens_hsa054141.97873051
16Oocyte meiosis_Homo sapiens_hsa041141.97525311
17Arginine and proline metabolism_Homo sapiens_hsa003301.85460009
18Selenocompound metabolism_Homo sapiens_hsa004501.85292772
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.83296253
20Histidine metabolism_Homo sapiens_hsa003401.81731130
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.79185295
22Glycerolipid metabolism_Homo sapiens_hsa005611.78130647
23Renin secretion_Homo sapiens_hsa049241.75833282
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73417945
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62078213
26Ether lipid metabolism_Homo sapiens_hsa005651.58190527
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.57421915
28Pentose phosphate pathway_Homo sapiens_hsa000301.56136174
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50274786
30* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49250677
31Circadian rhythm_Homo sapiens_hsa047101.44356558
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.43854560
33Long-term potentiation_Homo sapiens_hsa047201.41591472
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41223856
35beta-Alanine metabolism_Homo sapiens_hsa004101.27618599
36Cardiac muscle contraction_Homo sapiens_hsa042601.26756038
37Sphingolipid metabolism_Homo sapiens_hsa006001.24441497
38Cholinergic synapse_Homo sapiens_hsa047251.23795434
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.20279131
40PPAR signaling pathway_Homo sapiens_hsa033201.18114367
41Tight junction_Homo sapiens_hsa045301.17427932
42GnRH signaling pathway_Homo sapiens_hsa049121.16870936
43Bile secretion_Homo sapiens_hsa049761.15916616
44Long-term depression_Homo sapiens_hsa047301.13726468
45Melanogenesis_Homo sapiens_hsa049161.10138686
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09412115
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07783623
48Gap junction_Homo sapiens_hsa045401.06018398
49Insulin secretion_Homo sapiens_hsa049111.05580892
50mRNA surveillance pathway_Homo sapiens_hsa030151.04150548
51Circadian entrainment_Homo sapiens_hsa047131.04068615
52Calcium signaling pathway_Homo sapiens_hsa040201.03091306
53Mineral absorption_Homo sapiens_hsa049780.99984679
54Synaptic vesicle cycle_Homo sapiens_hsa047210.99483149
55Arginine biosynthesis_Homo sapiens_hsa002200.99320104
56Fructose and mannose metabolism_Homo sapiens_hsa000510.97899292
57Nitrogen metabolism_Homo sapiens_hsa009100.96587205
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96509312
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94328508
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92074842
61Gastric acid secretion_Homo sapiens_hsa049710.91766354
62Collecting duct acid secretion_Homo sapiens_hsa049660.90660083
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90334907
64Serotonergic synapse_Homo sapiens_hsa047260.88526224
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87924882
66Taste transduction_Homo sapiens_hsa047420.86355332
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.85600592
68Glutamatergic synapse_Homo sapiens_hsa047240.83937620
69Salivary secretion_Homo sapiens_hsa049700.83814535
70Fatty acid metabolism_Homo sapiens_hsa012120.82075547
71Olfactory transduction_Homo sapiens_hsa047400.80932644
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80216922
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.77863121
74ECM-receptor interaction_Homo sapiens_hsa045120.77286723
75ABC transporters_Homo sapiens_hsa020100.76935989
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76276564
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.74455051
78Insulin signaling pathway_Homo sapiens_hsa049100.73793647
79Glioma_Homo sapiens_hsa052140.73725024
80cAMP signaling pathway_Homo sapiens_hsa040240.73108872
81Phototransduction_Homo sapiens_hsa047440.72352845
82Rap1 signaling pathway_Homo sapiens_hsa040150.72093802
83Cocaine addiction_Homo sapiens_hsa050300.71462496
84N-Glycan biosynthesis_Homo sapiens_hsa005100.71264493
85Sulfur relay system_Homo sapiens_hsa041220.71231130
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.70915458
87Hedgehog signaling pathway_Homo sapiens_hsa043400.70653245
88Thyroid hormone synthesis_Homo sapiens_hsa049180.69713212
89Nicotine addiction_Homo sapiens_hsa050330.68878829
90Purine metabolism_Homo sapiens_hsa002300.68816447
91Focal adhesion_Homo sapiens_hsa045100.67518095
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65519302
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64023017
94Folate biosynthesis_Homo sapiens_hsa007900.63593955
95Alzheimers disease_Homo sapiens_hsa050100.63434279
96Ras signaling pathway_Homo sapiens_hsa040140.60910822
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60813682
98Carbon metabolism_Homo sapiens_hsa012000.60290351
99* MAPK signaling pathway_Homo sapiens_hsa040100.59926152
100Hippo signaling pathway_Homo sapiens_hsa043900.58697407
101Morphine addiction_Homo sapiens_hsa050320.58549000
102Dopaminergic synapse_Homo sapiens_hsa047280.58421595
103Ovarian steroidogenesis_Homo sapiens_hsa049130.56415324
104Arachidonic acid metabolism_Homo sapiens_hsa005900.56277131
105Wnt signaling pathway_Homo sapiens_hsa043100.56120030
106AMPK signaling pathway_Homo sapiens_hsa041520.54521304
107Pancreatic secretion_Homo sapiens_hsa049720.53756824
108Prion diseases_Homo sapiens_hsa050200.53243029
109* Estrogen signaling pathway_Homo sapiens_hsa049150.52588477
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.52429331
111Inositol phosphate metabolism_Homo sapiens_hsa005620.51673880
112Adherens junction_Homo sapiens_hsa045200.51290052
113RNA transport_Homo sapiens_hsa030130.51007355
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50172926
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49427547
116Oxytocin signaling pathway_Homo sapiens_hsa049210.48222932
117Axon guidance_Homo sapiens_hsa043600.48120841
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47515055
119VEGF signaling pathway_Homo sapiens_hsa043700.46984733
120Alcoholism_Homo sapiens_hsa050340.46516393
121ErbB signaling pathway_Homo sapiens_hsa040120.44219853
122Glutathione metabolism_Homo sapiens_hsa004800.43584709
123Protein digestion and absorption_Homo sapiens_hsa049740.43305705
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43237150
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42783185
126* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42152498
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.41706938
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.41676036
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41370311
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40996070
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40847884
132Fat digestion and absorption_Homo sapiens_hsa049750.40644649
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38859193
134* Endocytosis_Homo sapiens_hsa041440.36527694
135Basal cell carcinoma_Homo sapiens_hsa052170.34779600
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34423591
137Vibrio cholerae infection_Homo sapiens_hsa051100.34082390
138Sulfur metabolism_Homo sapiens_hsa009200.33600189
139Choline metabolism in cancer_Homo sapiens_hsa052310.33030931
140Chemical carcinogenesis_Homo sapiens_hsa052040.32673992
141Type II diabetes mellitus_Homo sapiens_hsa049300.32404344
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32011249
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30308300
144Fatty acid elongation_Homo sapiens_hsa000620.28849631
145Fatty acid degradation_Homo sapiens_hsa000710.28844811
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28656649
147Salmonella infection_Homo sapiens_hsa051320.28276684
148Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27008412
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26693915

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