HSPA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.61393017
2nuclear pore organization (GO:0006999)6.54796208
3behavioral response to nicotine (GO:0035095)6.26577401
4membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.36053179
5DNA unwinding involved in DNA replication (GO:0006268)5.05011466
6pre-miRNA processing (GO:0031054)4.94582757
7membrane repolarization during action potential (GO:0086011)4.90237017
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.89475318
9pore complex assembly (GO:0046931)4.76542100
10mitotic sister chromatid cohesion (GO:0007064)4.66056300
11regulation of DNA endoreduplication (GO:0032875)4.64396659
12regulation of gene silencing by RNA (GO:0060966)4.62130775
13regulation of posttranscriptional gene silencing (GO:0060147)4.62130775
14regulation of gene silencing by miRNA (GO:0060964)4.62130775
15mitotic nuclear envelope disassembly (GO:0007077)4.57122410
16folic acid-containing compound biosynthetic process (GO:0009396)4.53597359
17protein localization to kinetochore (GO:0034501)4.51870097
18heterochromatin organization (GO:0070828)4.49445749
19regulation of translational termination (GO:0006449)4.46531401
20membrane disassembly (GO:0030397)4.43460052
21nuclear envelope disassembly (GO:0051081)4.43460052
22negative regulation of potassium ion transmembrane transport (GO:1901380)4.37539140
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.37422224
24regulation of translational fidelity (GO:0006450)4.21275328
25DNA replication-dependent nucleosome assembly (GO:0006335)4.18789515
26DNA replication-dependent nucleosome organization (GO:0034723)4.18789515
27cell proliferation in forebrain (GO:0021846)4.12126975
28negative regulation of histone methylation (GO:0031061)4.10728345
29IMP biosynthetic process (GO:0006188)4.02546793
30regulation of RNA export from nucleus (GO:0046831)4.01681961
31somite development (GO:0061053)4.01489300
32DNA duplex unwinding (GO:0032508)3.97650788
33DNA geometric change (GO:0032392)3.96320257
34regulation of histone H3-K9 methylation (GO:0051570)3.95402030
35ribosome assembly (GO:0042255)3.77573967
36mitotic chromosome condensation (GO:0007076)3.73396466
37sister chromatid segregation (GO:0000819)3.70666660
38regulation of spindle organization (GO:0090224)3.68920878
39mitotic metaphase plate congression (GO:0007080)3.68039307
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.67071368
41regulation of centriole replication (GO:0046599)3.66852460
42regulation of mitotic spindle organization (GO:0060236)3.66039904
43tooth mineralization (GO:0034505)3.65183537
44protein localization to chromosome, centromeric region (GO:0071459)3.64991974
45IMP metabolic process (GO:0046040)3.64845593
46membrane repolarization (GO:0086009)3.61129274
47regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.57095363
48chromatin assembly (GO:0031497)3.56285501
49substrate-independent telencephalic tangential migration (GO:0021826)3.55038413
50substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.55038413
51cellular anion homeostasis (GO:0030002)3.52722521
52positive regulation of chromosome segregation (GO:0051984)3.50581760
53negative regulation of DNA repair (GO:0045738)3.50421747
54nuclear envelope organization (GO:0006998)3.50360045
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50293938
56NLS-bearing protein import into nucleus (GO:0006607)3.50246987
57positive regulation of SMAD protein import into nucleus (GO:0060391)3.50205894
58positive regulation of cardiac muscle cell differentiation (GO:2000727)3.48473698
59DNA replication initiation (GO:0006270)3.44976528
60histone H2A monoubiquitination (GO:0035518)3.44223367
61regulation of sister chromatid cohesion (GO:0007063)3.43346290
62mitotic sister chromatid segregation (GO:0000070)3.41886247
63regulation of centrosome cycle (GO:0046605)3.39327345
64regulation of helicase activity (GO:0051095)3.39203035
65paraxial mesoderm development (GO:0048339)3.39103279
66spliceosomal tri-snRNP complex assembly (GO:0000244)3.37967375
67regulation of non-canonical Wnt signaling pathway (GO:2000050)3.36100389
68positive regulation of mitotic sister chromatid separation (GO:1901970)3.33796901
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.33796901
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.33796901
71dosage compensation (GO:0007549)3.32099080
72maturation of SSU-rRNA (GO:0030490)3.31723240
73peptidyl-lysine dimethylation (GO:0018027)3.30183243
74metaphase plate congression (GO:0051310)3.30119549
75ribosomal small subunit biogenesis (GO:0042274)3.27733181
76nucleobase biosynthetic process (GO:0046112)3.27168498
77mRNA stabilization (GO:0048255)3.23051397
78RNA stabilization (GO:0043489)3.23051397
79negative regulation of response to food (GO:0032096)3.22377239
80negative regulation of appetite (GO:0032099)3.22377239
81regulation of nucleobase-containing compound transport (GO:0032239)3.21564543
82water-soluble vitamin biosynthetic process (GO:0042364)3.17332020
83spindle assembly involved in mitosis (GO:0090307)3.15940687
84somatic recombination of immunoglobulin gene segments (GO:0016447)3.15755915
85formation of translation preinitiation complex (GO:0001731)3.14745247
86somatic hypermutation of immunoglobulin genes (GO:0016446)3.14586045
87somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14586045
88L-serine metabolic process (GO:0006563)3.14338534
89peptidyl-arginine omega-N-methylation (GO:0035247)3.12677620
90regulation of membrane repolarization (GO:0060306)3.12014118
91regulation of potassium ion transmembrane transporter activity (GO:1901016)3.08877473
92DNA replication checkpoint (GO:0000076)3.05388094
93DNA conformation change (GO:0071103)3.05223693
94regulation of potassium ion transmembrane transport (GO:1901379)3.04902658
95regulation of centrosome duplication (GO:0010824)3.04470509
96regulation of chromosome segregation (GO:0051983)3.03045320
97gene silencing by RNA (GO:0031047)3.00634282
98chromatin assembly or disassembly (GO:0006333)2.99789693
99regulation of SMAD protein import into nucleus (GO:0060390)2.98559271
100negative regulation of cardiac muscle tissue development (GO:0055026)2.98342041
101microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.97053288
102mRNA transport (GO:0051028)2.94137733
103segment specification (GO:0007379)2.93733980
104peptidyl-arginine methylation (GO:0018216)2.92323827
105peptidyl-arginine N-methylation (GO:0035246)2.92323827
106trivalent inorganic anion homeostasis (GO:0072506)2.92214557
107phosphate ion homeostasis (GO:0055062)2.92214557
108negative regulation of transcription regulatory region DNA binding (GO:2000678)2.92047316
109fat-soluble vitamin catabolic process (GO:0042363)2.91188533
110vitamin catabolic process (GO:0009111)2.91188533
111protein localization to chromosome (GO:0034502)2.90813712
112positive regulation of T cell apoptotic process (GO:0070234)2.90176746
113DNA strand elongation involved in DNA replication (GO:0006271)2.89801212
114regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89242905
115spinal cord development (GO:0021510)2.88693107
116regulation of hippo signaling (GO:0035330)2.88410331
117negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.88168425
118negative regulation of histone modification (GO:0031057)2.87083917
119regulation of gene silencing (GO:0060968)2.86859074
120mitotic G1 DNA damage checkpoint (GO:0031571)2.85298219
121determination of adult lifespan (GO:0008340)2.84605224
122lung morphogenesis (GO:0060425)2.84182690
123establishment of chromosome localization (GO:0051303)2.84146760
124glucocorticoid receptor signaling pathway (GO:0042921)2.83854883
125kinetochore organization (GO:0051383)2.83750564
126negative regulation of chromosome segregation (GO:0051985)2.83276859
127mitotic spindle checkpoint (GO:0071174)2.82453694
128spindle checkpoint (GO:0031577)2.82399857
129anterior/posterior axis specification, embryo (GO:0008595)2.82092989
130viral transcription (GO:0019083)2.80836980
131regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80789835
132phosphorelay signal transduction system (GO:0000160)2.80461417
133purine nucleobase biosynthetic process (GO:0009113)2.80172187
134spindle assembly checkpoint (GO:0071173)2.80033151
135somatic diversification of immunoglobulins (GO:0016445)2.79196762
136negative regulation of chromatin modification (GO:1903309)2.78962783
137mitotic spindle assembly checkpoint (GO:0007094)2.78036117
138otic vesicle formation (GO:0030916)2.78035430
139lateral sprouting from an epithelium (GO:0060601)2.77144075
140negative regulation of mitotic sister chromatid separation (GO:2000816)2.76376481
141negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76376481
142negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76376481
143negative regulation of sister chromatid segregation (GO:0033046)2.76376481
144embryonic body morphogenesis (GO:0010172)2.75000428
145negative regulation of heart growth (GO:0061117)2.72763401
146negative regulation of cardiac muscle tissue growth (GO:0055022)2.72763401
147RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71316753
148tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71316753
149translational termination (GO:0006415)2.70806384
150lung-associated mesenchyme development (GO:0060484)2.70748574
151ribosomal small subunit assembly (GO:0000028)2.70719257
152V(D)J recombination (GO:0033151)2.69023818
153cell migration involved in gastrulation (GO:0042074)2.68222876
154regulation of heart rate by cardiac conduction (GO:0086091)2.67215561
155negative regulation of T cell differentiation in thymus (GO:0033085)2.67157211
156body morphogenesis (GO:0010171)2.64926971
157chromatin remodeling at centromere (GO:0031055)2.63189967
158snRNA transcription (GO:0009301)2.60591843
159retinal ganglion cell axon guidance (GO:0031290)2.60424153
160positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.60304665
161camera-type eye morphogenesis (GO:0048593)2.59468358
162pituitary gland development (GO:0021983)2.58478725
163regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54075813
164regulation of mitotic spindle checkpoint (GO:1903504)2.54075813
165cellular response to osmotic stress (GO:0071470)2.53793765
166negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.53648717
167ovulation cycle (GO:0042698)2.52015988
168positive regulation of mesonephros development (GO:0061213)2.46975294
169replicative senescence (GO:0090399)2.43761857
170head development (GO:0060322)2.43403808
171lung secretory cell differentiation (GO:0061140)2.43399311
172forebrain morphogenesis (GO:0048853)2.42533222
173CENP-A containing nucleosome assembly (GO:0034080)2.42460559
174positive regulation of fatty acid beta-oxidation (GO:0032000)2.39588507
175negative regulation of potassium ion transport (GO:0043267)2.39514989
176cellular potassium ion homeostasis (GO:0030007)2.38563446
177regulation of cardiac muscle cell proliferation (GO:0060043)2.37396110
178negative regulation of organelle assembly (GO:1902116)2.37364046
179negative regulation of glycogen biosynthetic process (GO:0045719)2.36546409
180telomere maintenance via semi-conservative replication (GO:0032201)2.36206894
181ribonucleoprotein complex biogenesis (GO:0022613)2.33193776
182endoderm formation (GO:0001706)2.32744311
183negative regulation of astrocyte differentiation (GO:0048712)2.32453346
184axon extension involved in axon guidance (GO:0048846)2.32448552
185neuron projection extension involved in neuron projection guidance (GO:1902284)2.32448552
186regulation of transcription regulatory region DNA binding (GO:2000677)2.31891740
187regulation of cardiac muscle cell differentiation (GO:2000725)2.30388630
188limb development (GO:0060173)2.27932104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.73701679
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.26623612
3EZH2_22144423_ChIP-Seq_EOC_Human4.98758272
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.88368610
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.72448034
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67543413
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.66768111
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.06657823
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89073690
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78996132
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.74613474
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.71461585
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64335757
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59965764
15AR_21909140_ChIP-Seq_LNCAP_Human2.52723325
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43158201
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.31537096
18MYC_22102868_ChIP-Seq_BL_Human2.30413426
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29640131
20IRF1_19129219_ChIP-ChIP_H3396_Human2.24866024
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24266167
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.23739582
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23429859
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.22282652
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.17187001
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14099104
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12242028
28ESR1_15608294_ChIP-ChIP_MCF-7_Human2.08455188
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07281531
30RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02034485
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93579743
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87723738
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.86847549
34* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81737325
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81291750
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80499610
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78648848
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.78167217
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77571995
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77571995
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77571995
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76627263
43* XRN2_22483619_ChIP-Seq_HELA_Human1.75749324
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.75635222
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73177606
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73035748
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72796016
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70635056
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70062799
50* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69227877
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64849035
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64348016
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.61614503
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61214135
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60273744
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52541702
57ZNF263_19887448_ChIP-Seq_K562_Human1.51368409
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49804393
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49513107
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.49260578
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.48014417
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.46701461
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46487826
64* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45223571
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44773866
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.44474565
67NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.44354110
68* NANOG_16153702_ChIP-ChIP_HESCs_Human1.42779498
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41199323
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40562567
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.38444676
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37719588
73EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37719588
74TCF3_18692474_ChIP-Seq_MESCs_Mouse1.33926845
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.33884863
76* KDM5A_27292631_Chip-Seq_BREAST_Human1.33609699
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33173456
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32719311
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31927315
80RNF2_27304074_Chip-Seq_NSC_Mouse1.31051906
81* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29867090
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29490733
83* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28322678
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28298152
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.25786881
86CLOCK_20551151_ChIP-Seq_293T_Human1.23794187
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.23345773
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22004275
89TTF2_22483619_ChIP-Seq_HELA_Human1.21941439
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20951957
91MYC_18940864_ChIP-ChIP_HL60_Human1.20932839
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.20450531
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19765670
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19472941
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19123272
96RNF2_27304074_Chip-Seq_ESCs_Mouse1.18177222
97* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17762235
98* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17707563
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17534528
100* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17003526
101* REST_21632747_ChIP-Seq_MESCs_Mouse1.16609284
102CIITA_25753668_ChIP-Seq_RAJI_Human1.16521837
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16487232
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.16201003
105NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14914567
106TFEB_21752829_ChIP-Seq_HELA_Human1.14783685
107* CHD1_26751641_Chip-Seq_LNCaP_Human1.14295526
108* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13008101
109HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11802561
110ETS1_20019798_ChIP-Seq_JURKAT_Human1.11792665
111ATF3_27146783_Chip-Seq_COLON_Human1.11372010
112TP63_17297297_ChIP-ChIP_HaCaT_Human1.10468539
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.09918433
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09431421
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07711263
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07113537
117EWS_26573619_Chip-Seq_HEK293_Human1.06612741
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05402193
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04672103
120JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04629036
121PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04116838
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04000760
123* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03697893
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03519778
125* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03393810
126SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03371274
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03070511
128ERG_21242973_ChIP-ChIP_JURKAT_Human1.03063923
129POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01169068
130* REST_18959480_ChIP-ChIP_MESCs_Mouse1.01142155
131RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98726781
132SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98524151
133GABP_19822575_ChIP-Seq_HepG2_Human0.98493892
134* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97167923
135EST1_17652178_ChIP-ChIP_JURKAT_Human0.96512968
136SOX2_18692474_ChIP-Seq_MESCs_Mouse0.96154897
137* VDR_23849224_ChIP-Seq_CD4+_Human0.96040947
138FUS_26573619_Chip-Seq_HEK293_Human0.95378780
139TCF7_22412390_ChIP-Seq_EML_Mouse0.95318926
140TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94914686
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94612653
142PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94367452
143STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94330071
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93481312
145DCP1A_22483619_ChIP-Seq_HELA_Human0.93478305
146KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93319643
147KDM2B_26808549_Chip-Seq_DND41_Human0.93079405
148* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92963426
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92295144
150FOXP3_21729870_ChIP-Seq_TREG_Human0.91649074
151TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91476297
152* ELK1_19687146_ChIP-ChIP_HELA_Human0.90096119
153OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89191994
154* RING1B_27294783_Chip-Seq_NPCs_Mouse0.87546059
155SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.85759057
156PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82164808
157* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80812806
158P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78557512
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78076422
160POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.78076422
161SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.77727860
162POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.77472030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.36192854
2MP0002837_dystrophic_cardiac_calcinosis6.24304734
3MP0006292_abnormal_olfactory_placode3.98479992
4MP0010352_gastrointestinal_tract_polyps3.86360672
5MP0003705_abnormal_hypodermis_morpholog3.47484142
6MP0010094_abnormal_chromosome_stability3.44874957
7MP0004957_abnormal_blastocyst_morpholog3.42195067
8MP0003111_abnormal_nucleus_morphology3.38568040
9MP0003693_abnormal_embryo_hatching3.31771215
10MP0003077_abnormal_cell_cycle2.96163491
11MP0005076_abnormal_cell_differentiation2.84000453
12MP0003123_paternal_imprinting2.77830626
13MP0001730_embryonic_growth_arrest2.71778023
14MP0008057_abnormal_DNA_replication2.68333240
15MP0010307_abnormal_tumor_latency2.66463934
16MP0010234_abnormal_vibrissa_follicle2.62358483
17MP0002160_abnormal_reproductive_system2.36141188
18MP0004130_abnormal_muscle_cell2.30479036
19MP0000350_abnormal_cell_proliferation2.27943296
20MP0000537_abnormal_urethra_morphology2.27150467
21MP0002084_abnormal_developmental_patter2.21103934
22MP0004197_abnormal_fetal_growth/weight/2.19127530
23MP0001672_abnormal_embryogenesis/_devel2.11805271
24MP0005380_embryogenesis_phenotype2.11805271
25MP0002086_abnormal_extraembryonic_tissu1.98376666
26MP0009053_abnormal_anal_canal1.97888155
27MP0001697_abnormal_embryo_size1.97827169
28MP0003984_embryonic_growth_retardation1.97150627
29MP0002088_abnormal_embryonic_growth/wei1.95024702
30MP0002085_abnormal_embryonic_tissue1.93184565
31MP0008007_abnormal_cellular_replicative1.92902072
32MP0003566_abnormal_cell_adhesion1.88121262
33MP0003890_abnormal_embryonic-extraembry1.84085896
34MP0008775_abnormal_heart_ventricle1.83894153
35MP0001853_heart_inflammation1.83162473
36MP0005623_abnormal_meninges_morphology1.81592529
37MP0000049_abnormal_middle_ear1.79423388
38MP0008932_abnormal_embryonic_tissue1.75847211
39MP0008877_abnormal_DNA_methylation1.74270145
40MP0002080_prenatal_lethality1.71634225
41MP0003567_abnormal_fetal_cardiomyocyte1.68951706
42MP0009250_abnormal_appendicular_skeleto1.68536623
43MP0008789_abnormal_olfactory_epithelium1.66590954
44MP0008058_abnormal_DNA_repair1.64558635
45MP0000778_abnormal_nervous_system1.63828443
46MP0003121_genomic_imprinting1.62840760
47MP0003119_abnormal_digestive_system1.58499308
48MP0002877_abnormal_melanocyte_morpholog1.54469777
49MP0001293_anophthalmia1.48106787
50MP0000733_abnormal_muscle_development1.48031923
51MP0010030_abnormal_orbit_morphology1.47601359
52MP0005394_taste/olfaction_phenotype1.44733288
53MP0005499_abnormal_olfactory_system1.44733288
54MP0005389_reproductive_system_phenotype1.40069821
55MP0009672_abnormal_birth_weight1.39430338
56MP0001849_ear_inflammation1.37319602
57MP0003283_abnormal_digestive_organ1.33540415
58MP0009379_abnormal_foot_pigmentation1.32567370
59MP0004233_abnormal_muscle_weight1.31671819
60MP0005023_abnormal_wound_healing1.29155951
61MP0009703_decreased_birth_body1.28784589
62MP0002163_abnormal_gland_morphology1.28281191
63MP0000428_abnormal_craniofacial_morphol1.25531461
64MP0002089_abnormal_postnatal_growth/wei1.24888737
65MP0000569_abnormal_digit_pigmentation1.23237967
66MP0005646_abnormal_pituitary_gland1.22672163
67MP0004185_abnormal_adipocyte_glucose1.22092231
68MP0003938_abnormal_ear_development1.21646975
69MP0003122_maternal_imprinting1.21111516
70MP0000631_abnormal_neuroendocrine_gland1.19124637
71MP0001485_abnormal_pinna_reflex1.17785980
72MP0003115_abnormal_respiratory_system1.14788506
73MP0003937_abnormal_limbs/digits/tail_de1.14405554
74MP0002653_abnormal_ependyma_morphology1.14295925
75MP0001915_intracranial_hemorrhage1.14080623
76MP0003787_abnormal_imprinting1.13871277
77MP0002396_abnormal_hematopoietic_system1.11526213
78MP0002697_abnormal_eye_size1.09854878
79MP0004808_abnormal_hematopoietic_stem1.09263389
80MP0002233_abnormal_nose_morphology1.08250115
81MP0003941_abnormal_skin_development1.06894841
82MP0005187_abnormal_penis_morphology1.06683333
83MP0002102_abnormal_ear_morphology1.06477546
84MP0005423_abnormal_somatic_nervous1.06438981
85MP0002092_abnormal_eye_morphology1.05115149
86MP0002925_abnormal_cardiovascular_devel1.03456303
87MP0000566_synostosis1.01570946
88MP0000313_abnormal_cell_death1.01397341
89MP0000955_abnormal_spinal_cord1.00688279
90MP0002111_abnormal_tail_morphology0.98556034
91MP0003806_abnormal_nucleotide_metabolis0.98160608
92MP0006072_abnormal_retinal_apoptosis0.95345711
93MP0002184_abnormal_innervation0.94985234
94MP0003315_abnormal_perineum_morphology0.94841319
95MP0004145_abnormal_muscle_electrophysio0.94615468
96MP0002932_abnormal_joint_morphology0.92110278
97MP0003935_abnormal_craniofacial_develop0.91951196
98MP0003880_abnormal_central_pattern0.91803961
99MP0003879_abnormal_hair_cell0.91583716
100MP0003091_abnormal_cell_migration0.91286612
101MP0003300_gastrointestinal_ulcer0.90134781
102MP0000432_abnormal_head_morphology0.89653495
103MP0002019_abnormal_tumor_incidence0.88938239
104MP0003861_abnormal_nervous_system0.88897192
105MP0000516_abnormal_urinary_system0.88351362
106MP0005367_renal/urinary_system_phenotyp0.88351362
107MP0006054_spinal_hemorrhage0.88179643
108MP0004264_abnormal_extraembryonic_tissu0.87576588
109MP0000678_abnormal_parathyroid_gland0.86781343
110MP0002210_abnormal_sex_determination0.86218422
111MP0008770_decreased_survivor_rate0.85111759
112MP0003786_premature_aging0.84241921
113MP0001145_abnormal_male_reproductive0.83737384
114MP0001666_abnormal_nutrient_absorption0.83468151
115MP0005621_abnormal_cell_physiology0.83323387
116MP0003136_yellow_coat_color0.83056538
117MP0002249_abnormal_larynx_morphology0.82973513
118MP0002234_abnormal_pharynx_morphology0.82541120
119MP0004133_heterotaxia0.82347586
120MP0002938_white_spotting0.81159273
121MP0004084_abnormal_cardiac_muscle0.81033773
122MP0000490_abnormal_crypts_of0.80970951
123MP0000266_abnormal_heart_morphology0.80534572
124MP0001348_abnormal_lacrimal_gland0.80055343
125MP0010630_abnormal_cardiac_muscle0.79913036
126MP0005379_endocrine/exocrine_gland_phen0.79179196
127MP0005384_cellular_phenotype0.77809180
128* MP0002152_abnormal_brain_morphology0.77702671
129MP0001286_abnormal_eye_development0.76629249
130MP0002116_abnormal_craniofacial_bone0.76273235
131MP0002752_abnormal_somatic_nervous0.76126002
132MP0005248_abnormal_Harderian_gland0.75885757
133MP0001529_abnormal_vocalization0.75671602
134MP0001188_hyperpigmentation0.75610381
135MP0002081_perinatal_lethality0.75452626
136MP0003755_abnormal_palate_morphology0.75354242
137MP0006276_abnormal_autonomic_nervous0.75014434
138MP0000534_abnormal_ureter_morphology0.74060312
139MP0008438_abnormal_cutaneous_collagen0.73773075
140MP0003221_abnormal_cardiomyocyte_apopto0.72440446
141MP0010678_abnormal_skin_adnexa0.71843387
142MP0003385_abnormal_body_wall0.71632035
143MP0001440_abnormal_grooming_behavior0.71224385
144MP0002272_abnormal_nervous_system0.70702639
145MP0002269_muscular_atrophy0.69800900
146MP0000026_abnormal_inner_ear0.69757324
147MP0001299_abnormal_eye_distance/0.67922139
148MP0005666_abnormal_adipose_tissue0.66562822
149MP0002638_abnormal_pupillary_reflex0.66364984
150MP0003718_maternal_effect0.65976225
151MP0001784_abnormal_fluid_regulation0.64993241
152MP0000653_abnormal_sex_gland0.64458098
153MP0002882_abnormal_neuron_morphology0.64081227
154MP0000477_abnormal_intestine_morphology0.63623635
155MP0005195_abnormal_posterior_eye0.63178942
156MP0009278_abnormal_bone_marrow0.63154735
157MP0002114_abnormal_axial_skeleton0.62576962
158MP0003942_abnormal_urinary_system0.61305708
159MP0002733_abnormal_thermal_nociception0.60066567

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.63158291
2Osteomalacia (HP:0002749)4.12198789
3Abnormality of the proximal phalanges of the hand (HP:0009834)3.93798766
4Astrocytoma (HP:0009592)3.88327349
5Abnormality of the astrocytes (HP:0100707)3.88327349
6Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.84694150
7Abnormality of the phalanges of the 5th finger (HP:0004213)3.77040904
8Abnormality of the middle phalanges of the toes (HP:0010183)3.63393228
9Colon cancer (HP:0003003)3.37998948
10Symphalangism affecting the phalanges of the hand (HP:0009773)3.28672058
11Septo-optic dysplasia (HP:0100842)3.27342619
12Medulloblastoma (HP:0002885)3.26395384
13Biliary tract neoplasm (HP:0100574)3.25828715
14Glioma (HP:0009733)3.06605764
15Rhabdomyosarcoma (HP:0002859)3.01167037
16Selective tooth agenesis (HP:0001592)2.97410915
17Abnormality of the labia minora (HP:0012880)2.96960710
18Deviation of the thumb (HP:0009603)2.96829788
19Fibular aplasia (HP:0002990)2.96662352
20Proximal placement of thumb (HP:0009623)2.91990667
21Neoplasm of the oral cavity (HP:0100649)2.87776567
22Increased nuchal translucency (HP:0010880)2.82986412
23Volvulus (HP:0002580)2.78992883
24Aplasia/Hypoplasia of the fibula (HP:0006492)2.68409770
25Short femoral neck (HP:0100864)2.66989295
26Gastrointestinal carcinoma (HP:0002672)2.61874503
27Malignant gastrointestinal tract tumors (HP:0006749)2.61874503
28Abnormality of the nasal septum (HP:0000419)2.60916255
29Abnormality of the lower motor neuron (HP:0002366)2.56110895
30Neoplasm of striated muscle (HP:0009728)2.55030553
31Short 4th metacarpal (HP:0010044)2.50694850
32Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50694850
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50367150
34Reticulocytopenia (HP:0001896)2.49539587
35Synostosis of carpal bones (HP:0005048)2.49350415
36Morphological abnormality of the middle ear (HP:0008609)2.48153155
37Missing ribs (HP:0000921)2.45604514
38Aplasia involving bones of the upper limbs (HP:0009823)2.44456762
39Aplasia of the phalanges of the hand (HP:0009802)2.44456762
40Aplasia involving bones of the extremities (HP:0009825)2.44456762
41Agnosia (HP:0010524)2.42786470
42Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.40643968
43Basal cell carcinoma (HP:0002671)2.38009727
44Ectopic kidney (HP:0000086)2.35566975
45Abnormality of cells of the erythroid lineage (HP:0012130)2.34905837
46Shallow orbits (HP:0000586)2.33818524
47Humeroradial synostosis (HP:0003041)2.31731642
48Synostosis involving the elbow (HP:0003938)2.31731642
49Subacute progressive viral hepatitis (HP:0006572)2.30750186
50Pelvic girdle muscle weakness (HP:0003749)2.29603542
51Neoplasm of the adrenal cortex (HP:0100641)2.28774816
52Adrenal hypoplasia (HP:0000835)2.27722119
53Angiofibromas (HP:0010615)2.26658719
54Adenoma sebaceum (HP:0009720)2.26658719
55Mesomelia (HP:0003027)2.26352542
56Short hallux (HP:0010109)2.26048101
57Hyperacusis (HP:0010780)2.25432173
58Heterotopia (HP:0002282)2.24675907
59Hyperglycinemia (HP:0002154)2.24538087
60Hepatoblastoma (HP:0002884)2.24241067
61Fibular hypoplasia (HP:0003038)2.23473349
62Pseudobulbar signs (HP:0002200)2.22392736
63Nephronophthisis (HP:0000090)2.21622258
64Patent foramen ovale (HP:0001655)2.20568812
65Rectal prolapse (HP:0002035)2.19434835
66Abnormal pancreas size (HP:0012094)2.18543158
67Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.16481910
68Abnormality of cochlea (HP:0000375)2.16293974
69Absent phalangeal crease (HP:0006109)2.15732452
70Birth length less than 3rd percentile (HP:0003561)2.14747665
71Abnormality of the phalanges of the 2nd finger (HP:0009541)2.13363371
72Abnormality of DNA repair (HP:0003254)2.13248953
73Uterine neoplasm (HP:0010784)2.12692810
74Fibroma (HP:0010614)2.12395467
75Aplasia/Hypoplasia of the hallux (HP:0008362)2.11583936
76Renal duplication (HP:0000075)2.10866697
77Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.10646782
78Short humerus (HP:0005792)2.10221298
79Fibrous tissue neoplasm (HP:0012316)2.10025008
80Ankle contracture (HP:0006466)2.09259648
81Bowel diverticulosis (HP:0005222)2.08903992
82Cutaneous finger syndactyly (HP:0010554)2.08688835
83Broad hallux (HP:0010055)2.08146821
84Spastic diplegia (HP:0001264)2.07856275
85Maternal diabetes (HP:0009800)2.07613941
86Aplasia/hypoplasia of the humerus (HP:0006507)2.05890900
87Carpal synostosis (HP:0009702)2.04282706
88Degeneration of anterior horn cells (HP:0002398)2.03944164
89Abnormality of the anterior horn cell (HP:0006802)2.03944164
90Synostosis involving bones of the hand (HP:0004278)2.03353615
912-3 toe syndactyly (HP:0004691)2.03328947
92Sandal gap (HP:0001852)2.03188312
93Abnormality of the 1st metacarpal (HP:0010009)2.03023584
94Intestinal polyp (HP:0005266)2.02479245
95Intestinal polyposis (HP:0200008)2.01674323
96Abnormality of the 4th metacarpal (HP:0010012)2.01415872
97Neoplasm of the rectum (HP:0100743)2.01381241
98Urethral obstruction (HP:0000796)2.01304638
99Asplenia (HP:0001746)2.01088609
100Shoulder girdle muscle weakness (HP:0003547)2.00964430
101Neoplasm of the small intestine (HP:0100833)2.00583561
102Cutaneous syndactyly (HP:0012725)1.99829353
103Broad thumb (HP:0011304)1.98494250
104Genu recurvatum (HP:0002816)1.97929838
105Hand muscle atrophy (HP:0009130)1.97774755
106Skull defect (HP:0001362)1.97031472
107Protrusio acetabuli (HP:0003179)1.96883783
108Multiple enchondromatosis (HP:0005701)1.96742006
109Aplasia/Hypoplasia of the spleen (HP:0010451)1.96132263
110Cerebral aneurysm (HP:0004944)1.95321809
111Cortical dysplasia (HP:0002539)1.95242478
112Absent thumb (HP:0009777)1.93410916
113Ovarian neoplasm (HP:0100615)1.93303386
114High pitched voice (HP:0001620)1.93160407
115Prominent nose (HP:0000448)1.92385536
116Atresia of the external auditory canal (HP:0000413)1.89731456
117Long eyelashes (HP:0000527)1.89646467
118Hypopigmentation of the fundus (HP:0007894)1.89640772
119Absent septum pellucidum (HP:0001331)1.89076174
120Molar tooth sign on MRI (HP:0002419)1.88954405
121Abnormality of midbrain morphology (HP:0002418)1.88954405
122Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.88057641
123Renovascular hypertension (HP:0100817)1.87617080
124Abnormality of the musculature of the pelvis (HP:0001469)1.87302356
125Abnormality of the hip-girdle musculature (HP:0001445)1.87302356
126Distal upper limb amyotrophy (HP:0007149)1.85534369
127Upper limb amyotrophy (HP:0009129)1.85534369
128Rib fusion (HP:0000902)1.85262573
129Facial hemangioma (HP:0000329)1.84787492
130Cafe-au-lait spot (HP:0000957)1.84763614
131Broad toe (HP:0001837)1.84212015
132Increased density of long bones (HP:0006392)1.83608736
133Abnormal biliary tract morphology (HP:0012440)1.83536379
134Aplasia/Hypoplasia of the patella (HP:0006498)1.83239273
135Abnormal number of incisors (HP:0011064)1.82981536
136Abnormality of abdominal situs (HP:0011620)1.82949031
137Abdominal situs inversus (HP:0003363)1.82949031
138Impulsivity (HP:0100710)1.81517491
139Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.79922090
140Neoplasm of the pancreas (HP:0002894)1.79782194
141Anencephaly (HP:0002323)1.79367045
142Supernumerary ribs (HP:0005815)1.79072650
143Hypoplasia of the ulna (HP:0003022)1.78981217
144Optic nerve hypoplasia (HP:0000609)1.78796710
145Decreased circulating renin level (HP:0003351)1.78650576
146Hypoplastic pelvis (HP:0008839)1.78492318
147Ankyloglossia (HP:0010296)1.76977150
148Stenosis of the external auditory canal (HP:0000402)1.76905627
149Patellar aplasia (HP:0006443)1.76684056
150Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75654152
151Oligodontia (HP:0000677)1.75167064
152Shawl scrotum (HP:0000049)1.74837150
153Esophageal atresia (HP:0002032)1.74737253
154Genetic anticipation (HP:0003743)1.74588068
155Abnormality of the calcaneus (HP:0008364)1.74535731
156Horseshoe kidney (HP:0000085)1.74350739
157Aplasia/Hypoplasia of the sternum (HP:0006714)1.73711685
158Pointed chin (HP:0000307)1.73365124
159Cutaneous melanoma (HP:0012056)1.73118173
160Abnormality of the 2nd finger (HP:0004100)1.72891414
161Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.72827636
162Short 1st metacarpal (HP:0010034)1.72827636
163Abnormality of chromosome stability (HP:0003220)1.72603530
164High anterior hairline (HP:0009890)1.71115775
165Abnormality of the distal phalanges of the toes (HP:0010182)1.70879465
166Absent radius (HP:0003974)1.69876991
167Resting tremor (HP:0002322)1.69731965
168Atrophy/Degeneration involving motor neurons (HP:0007373)1.69364668
169Abnormal number of erythroid precursors (HP:0012131)1.69219105
170Back pain (HP:0003418)1.69206382
171Chromsome breakage (HP:0040012)1.69071691
172Amaurosis fugax (HP:0100576)1.68536009
173True hermaphroditism (HP:0010459)1.68203706
174Neoplasm of the colon (HP:0100273)1.68037456
175Obsessive-compulsive behavior (HP:0000722)1.67249715
176Abnormal finger flexion creases (HP:0006143)1.66777942
177Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66598070
178Aplasia/hypoplasia of the femur (HP:0005613)1.66041639
179Abnormality of renal resorption (HP:0011038)1.66011284
180Abnormality of the renal collecting system (HP:0004742)1.65807974
181Abnormality of the septum pellucidum (HP:0007375)1.63772802
182Aplasia/Hypoplasia of the ulna (HP:0006495)1.63407221
183Short tibia (HP:0005736)1.61231433
184Pendular nystagmus (HP:0012043)1.60090637
185Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60076438
186Enlarged kidneys (HP:0000105)1.59821048
187Pancreatic fibrosis (HP:0100732)1.59063480
188Macrocytic anemia (HP:0001972)1.58332548
189Aplasia/Hypoplasia of the uvula (HP:0010293)1.58322129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.03690976
2CDC73.94038430
3NEK12.93840004
4PKN22.77870158
5WEE12.76195808
6STK162.70832430
7WNK42.61129687
8NEK22.60266686
9SCYL22.47513332
10EEF2K2.43731319
11MAP3K42.28050825
12TTK2.14087195
13EPHA22.11527383
14ALK2.07086300
15TSSK62.01646127
16LATS11.89038787
17RPS6KB21.82337993
18PNCK1.77644600
19BRD41.77429303
20CASK1.75436732
21STK391.75028489
22EPHB21.72620619
23TRIB31.71378506
24RPS6KA21.70992237
25LATS21.66107381
26MAP3K101.63146737
27PASK1.58163833
28ZAK1.56706318
29TAF11.52604937
30DYRK21.51395851
31BUB11.50219560
32CDK61.45225984
33PLK31.44562452
34PLK11.42517409
35FRK1.42194992
36MAP3K81.41581534
37ATR1.35522280
38TTN1.35461634
39CHEK11.35061388
40PLK21.34082095
41MTOR1.33340885
42CDK41.33056323
43SRPK11.28343818
44PAK41.25267059
45EIF2AK11.24372524
46BRAF1.21719994
47PDGFRA1.21220750
48ACVR1B1.20168556
49NTRK21.18999849
50RIPK11.18841911
51AURKB1.18328652
52STK101.17901249
53CDK71.17526336
54STK31.12123284
55MKNK11.10935345
56RPS6KA61.10156004
57RPS6KA41.10006472
58CHEK21.06977641
59FGFR11.05293958
60PDK31.04699798
61PDK41.04699798
62SGK2231.04664638
63SGK4941.04664638
64TGFBR11.04475462
65ATM1.02890246
66NTRK31.01701925
67BRSK21.01343029
68CDK21.00891410
69RPS6KL11.00386414
70RPS6KC11.00386414
71FGFR20.99918058
72PAK20.99587932
73PTK60.98919719
74SMG10.97620367
75MAP2K70.93998016
76CAMK1D0.93320133
77BMX0.92403532
78SGK20.90054438
79GRK10.88979278
80LRRK20.87709289
81PINK10.85811342
82ICK0.84800481
83MET0.84439743
84SGK10.82804162
85PRKD30.82096041
86TESK20.80723681
87PRKD20.80656978
88CSNK1E0.80436002
89CSNK1D0.79571776
90FLT30.77935807
91KSR10.76995704
92ABL20.76345584
93STK240.75376352
94PIK3CA0.75155380
95MAPKAPK50.75045881
96MAP3K90.74379275
97SGK30.74210784
98CDK10.72378319
99PHKG10.72135779
100PHKG20.72135779
101KSR20.71425762
102CSNK1G20.69226466
103PRKCG0.69105276
104MKNK20.68281205
105MELK0.67973860
106AURKA0.67672418
107TESK10.66134669
108VRK20.65694251
109STK110.65544832
110DYRK1A0.64868057
111PRKDC0.62006699
112WNK30.61477941
113PBK0.61205831
114TYRO30.61019682
115DDR20.59451227
116TNIK0.58809769
117CDK140.58082455
118BRSK10.57872107
119DMPK0.56725185
120CAMK1G0.56527421
121BMPR1B0.55300029
122STK38L0.55221493
123PLK40.55094378
124STK40.54980977
125CDK190.54512707
126VRK10.53763304
127CSNK2A10.53652896
128RPS6KA10.52804615
129NME10.51462113
130CSNK2A20.51446817
131ERBB40.50953754
132MAP2K40.50300192
133DYRK30.49044025
134CDK150.47477410
135AKT20.47440670
136CDK11A0.47384641
137PTK20.46712112
138CDK80.46688754
139MINK10.46257005
140MAPK140.46024635
141FER0.46007878
142TLK10.45457639
143RET0.45053937
144TAOK10.44499292
145PDGFRB0.44344655
146MARK10.44216000
147ERBB20.43758085
148PDK20.43341000
149PAK60.43139744
150GSK3B0.38668923
151PIM10.38563076
152MAPK100.37773167
153PRKCI0.37014620
154PAK10.36823933
155MAP3K20.36494605
156FGFR30.34390842
157MAPK10.33330489
158CDK90.31856246
159AKT10.31283763

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030133.36329388
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.29817427
3DNA replication_Homo sapiens_hsa030303.20622073
4Mismatch repair_Homo sapiens_hsa034303.13398290
5One carbon pool by folate_Homo sapiens_hsa006703.04547431
6Ribosome_Homo sapiens_hsa030103.03939561
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.78279318
8Spliceosome_Homo sapiens_hsa030402.66236142
9Cell cycle_Homo sapiens_hsa041102.64730377
10mRNA surveillance pathway_Homo sapiens_hsa030152.36827702
11Nucleotide excision repair_Homo sapiens_hsa034201.82361564
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.81735185
13Type II diabetes mellitus_Homo sapiens_hsa049301.79587485
14Cardiac muscle contraction_Homo sapiens_hsa042601.73178651
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70218511
16Pyruvate metabolism_Homo sapiens_hsa006201.65550919
17MicroRNAs in cancer_Homo sapiens_hsa052061.61484484
18Oocyte meiosis_Homo sapiens_hsa041141.60157874
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58648537
20Base excision repair_Homo sapiens_hsa034101.54017378
21p53 signaling pathway_Homo sapiens_hsa041151.52978743
22Nicotine addiction_Homo sapiens_hsa050331.52814234
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51762635
24Nitrogen metabolism_Homo sapiens_hsa009101.50387145
25Hippo signaling pathway_Homo sapiens_hsa043901.48025709
26Adherens junction_Homo sapiens_hsa045201.46226448
27mTOR signaling pathway_Homo sapiens_hsa041501.45286401
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42611895
29Homologous recombination_Homo sapiens_hsa034401.42375267
30Viral carcinogenesis_Homo sapiens_hsa052031.41754414
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41618280
32Non-homologous end-joining_Homo sapiens_hsa034501.40569253
33RNA degradation_Homo sapiens_hsa030181.40088029
34Fanconi anemia pathway_Homo sapiens_hsa034601.31928190
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.31471809
36Selenocompound metabolism_Homo sapiens_hsa004501.28140510
37Systemic lupus erythematosus_Homo sapiens_hsa053221.27292227
38Thyroid cancer_Homo sapiens_hsa052161.26609785
39Small cell lung cancer_Homo sapiens_hsa052221.23508021
40Phototransduction_Homo sapiens_hsa047441.22016265
41Axon guidance_Homo sapiens_hsa043601.21269510
42Oxidative phosphorylation_Homo sapiens_hsa001901.21221658
43Chronic myeloid leukemia_Homo sapiens_hsa052201.19890339
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19698481
45Parkinsons disease_Homo sapiens_hsa050121.19509441
46Huntingtons disease_Homo sapiens_hsa050161.16058892
47Colorectal cancer_Homo sapiens_hsa052101.15261441
48Proteoglycans in cancer_Homo sapiens_hsa052051.15106709
49Biosynthesis of amino acids_Homo sapiens_hsa012301.14380780
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14045999
51Basal cell carcinoma_Homo sapiens_hsa052171.13258553
52TGF-beta signaling pathway_Homo sapiens_hsa043501.13169149
53HTLV-I infection_Homo sapiens_hsa051661.10378261
54Bladder cancer_Homo sapiens_hsa052191.10290942
55Lysine degradation_Homo sapiens_hsa003101.04410042
56Tight junction_Homo sapiens_hsa045301.01050481
57Endometrial cancer_Homo sapiens_hsa052130.99705136
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99571350
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96199064
60Sulfur relay system_Homo sapiens_hsa041220.94700413
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94345742
62Glutamatergic synapse_Homo sapiens_hsa047240.92911052
63Epstein-Barr virus infection_Homo sapiens_hsa051690.90698885
64Purine metabolism_Homo sapiens_hsa002300.89919047
65Basal transcription factors_Homo sapiens_hsa030220.89081860
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88747897
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88132084
68Glioma_Homo sapiens_hsa052140.87586990
69Focal adhesion_Homo sapiens_hsa045100.87373516
70Non-small cell lung cancer_Homo sapiens_hsa052230.83273422
71Protein export_Homo sapiens_hsa030600.82156214
72Alzheimers disease_Homo sapiens_hsa050100.81527092
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80243139
74Cholinergic synapse_Homo sapiens_hsa047250.80013875
75Morphine addiction_Homo sapiens_hsa050320.79358712
76Hedgehog signaling pathway_Homo sapiens_hsa043400.78720970
77RNA polymerase_Homo sapiens_hsa030200.78358466
78Prostate cancer_Homo sapiens_hsa052150.78248057
79Viral myocarditis_Homo sapiens_hsa054160.77480314
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.77157297
81Dopaminergic synapse_Homo sapiens_hsa047280.76431690
82Olfactory transduction_Homo sapiens_hsa047400.76374941
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74817792
84HIF-1 signaling pathway_Homo sapiens_hsa040660.74034461
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.73167838
86Notch signaling pathway_Homo sapiens_hsa043300.72716836
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71745553
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70910690
89Renal cell carcinoma_Homo sapiens_hsa052110.70854680
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68632732
91Wnt signaling pathway_Homo sapiens_hsa043100.68444102
92Estrogen signaling pathway_Homo sapiens_hsa049150.68363176
93Serotonergic synapse_Homo sapiens_hsa047260.68088512
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67463982
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67047118
96Alcoholism_Homo sapiens_hsa050340.66983945
97GABAergic synapse_Homo sapiens_hsa047270.66662265
98Dorso-ventral axis formation_Homo sapiens_hsa043200.66608292
99Pyrimidine metabolism_Homo sapiens_hsa002400.66069984
100Pathways in cancer_Homo sapiens_hsa052000.65809175
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.65681341
102Carbon metabolism_Homo sapiens_hsa012000.63694456
103Vitamin B6 metabolism_Homo sapiens_hsa007500.63635037
104Steroid biosynthesis_Homo sapiens_hsa001000.63577020
105Propanoate metabolism_Homo sapiens_hsa006400.61534872
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60632624
107Dilated cardiomyopathy_Homo sapiens_hsa054140.60531541
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60023273
109Glucagon signaling pathway_Homo sapiens_hsa049220.59419285
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.59237906
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58817568
112AMPK signaling pathway_Homo sapiens_hsa041520.57130202
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56909854
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56630876
115Arginine and proline metabolism_Homo sapiens_hsa003300.56439736
116Melanoma_Homo sapiens_hsa052180.55934553
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55714740
118Pancreatic cancer_Homo sapiens_hsa052120.54993042
119ECM-receptor interaction_Homo sapiens_hsa045120.54618162
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54608787
121Herpes simplex infection_Homo sapiens_hsa051680.54276694
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54208277
123FoxO signaling pathway_Homo sapiens_hsa040680.53478476
124* Antigen processing and presentation_Homo sapiens_hsa046120.53122216
125Insulin signaling pathway_Homo sapiens_hsa049100.50576202
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49105959
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48750120
128Circadian entrainment_Homo sapiens_hsa047130.47660064
129Insulin secretion_Homo sapiens_hsa049110.47616750
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.47546278
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47078620
132VEGF signaling pathway_Homo sapiens_hsa043700.45674722
133Hepatitis B_Homo sapiens_hsa051610.44491139
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44198727
135Apoptosis_Homo sapiens_hsa042100.42138512
136Acute myeloid leukemia_Homo sapiens_hsa052210.41440543
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40985167
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40570373
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40549920
140Insulin resistance_Homo sapiens_hsa049310.40115209
141ErbB signaling pathway_Homo sapiens_hsa040120.39921846
142Metabolic pathways_Homo sapiens_hsa011000.39688645
143MAPK signaling pathway_Homo sapiens_hsa040100.39636295
144Pentose phosphate pathway_Homo sapiens_hsa000300.39311413
145Retinol metabolism_Homo sapiens_hsa008300.38356974
146Amoebiasis_Homo sapiens_hsa051460.36707265
147Tryptophan metabolism_Homo sapiens_hsa003800.36696123
148Rap1 signaling pathway_Homo sapiens_hsa040150.35907838
149Legionellosis_Homo sapiens_hsa051340.35317063
150Melanogenesis_Homo sapiens_hsa049160.34594981
151Synaptic vesicle cycle_Homo sapiens_hsa047210.33435738
152Oxytocin signaling pathway_Homo sapiens_hsa049210.33346516
153Taste transduction_Homo sapiens_hsa047420.32634615
154beta-Alanine metabolism_Homo sapiens_hsa004100.30622267
155Starch and sucrose metabolism_Homo sapiens_hsa005000.30571098

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