HSPA4L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.23509874
2axonemal dynein complex assembly (GO:0070286)6.74397320
3cilium movement (GO:0003341)6.16512173
4epithelial cilium movement (GO:0003351)5.80810888
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.39009698
6motile cilium assembly (GO:0044458)5.24253076
7sperm motility (GO:0030317)4.92006272
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.77305052
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56052593
10acrosome reaction (GO:0007340)4.54243129
11synaptic vesicle exocytosis (GO:0016079)4.47344452
12fusion of sperm to egg plasma membrane (GO:0007342)4.44827656
13acrosome assembly (GO:0001675)4.31432835
14vocalization behavior (GO:0071625)4.18850434
15regulation of synaptic vesicle exocytosis (GO:2000300)4.18260705
16synaptic vesicle maturation (GO:0016188)4.14197515
17axoneme assembly (GO:0035082)4.10756363
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.06826749
19locomotory exploration behavior (GO:0035641)4.03585486
20glutamate secretion (GO:0014047)4.02287773
21synapsis (GO:0007129)3.97042698
22negative regulation of inclusion body assembly (GO:0090084)3.95251046
23protein localization to cilium (GO:0061512)3.92227516
24neuronal action potential propagation (GO:0019227)3.91590699
25ventricular system development (GO:0021591)3.90379319
26calcium ion-dependent exocytosis (GO:0017156)3.89359706
27neuron cell-cell adhesion (GO:0007158)3.88254642
28regulation of cilium movement (GO:0003352)3.85100542
29plasma membrane fusion (GO:0045026)3.84511792
30protein localization to synapse (GO:0035418)3.84375181
31piRNA metabolic process (GO:0034587)3.83218809
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.76592792
33neurotransmitter secretion (GO:0007269)3.74568922
34regulation of synaptic vesicle transport (GO:1902803)3.70205717
35regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.68388708
36cellular potassium ion homeostasis (GO:0030007)3.60238138
37multicellular organism reproduction (GO:0032504)3.59217105
38regulation of glutamate receptor signaling pathway (GO:1900449)3.58295899
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.55618617
40glutamate receptor signaling pathway (GO:0007215)3.52060146
41behavioral response to nicotine (GO:0035095)3.51135393
42neuron-neuron synaptic transmission (GO:0007270)3.50636608
43spermatid development (GO:0007286)3.47608208
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44098054
45membrane depolarization during action potential (GO:0086010)3.43470896
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41733164
47male meiosis (GO:0007140)3.37736388
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.35893390
49synaptic transmission, glutamatergic (GO:0035249)3.35834195
50cerebellar Purkinje cell differentiation (GO:0021702)3.35219672
51gamma-aminobutyric acid transport (GO:0015812)3.35193959
52gamma-aminobutyric acid signaling pathway (GO:0007214)3.35021370
53neurotransmitter transport (GO:0006836)3.34720724
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29322306
55nonmotile primary cilium assembly (GO:0035058)3.29282488
56sperm-egg recognition (GO:0035036)3.28453178
57exploration behavior (GO:0035640)3.28439465
58intraciliary transport (GO:0042073)3.26773311
59sodium ion export (GO:0071436)3.26478976
60response to pheromone (GO:0019236)3.22623667
61centriole replication (GO:0007099)3.18962073
62DNA methylation involved in gamete generation (GO:0043046)3.15422359
63cell wall macromolecule metabolic process (GO:0044036)3.08265419
64cell wall macromolecule catabolic process (GO:0016998)3.08265419
65regulation of neuronal synaptic plasticity (GO:0048168)3.07854582
66chromosome organization involved in meiosis (GO:0070192)3.06522613
67regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05092896
68long-term synaptic potentiation (GO:0060291)3.04750476
69regulation of vesicle fusion (GO:0031338)3.03896285
70mating behavior (GO:0007617)3.01957030
71negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99184223
72presynaptic membrane assembly (GO:0097105)2.98421673
73cerebellar granule cell differentiation (GO:0021707)2.98181379
74response to histamine (GO:0034776)2.97517510
75microtubule depolymerization (GO:0007019)2.97125204
76cellular ketone body metabolic process (GO:0046950)2.95830880
77G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95131888
78regulation of excitatory postsynaptic membrane potential (GO:0060079)2.94668896
79regulation of neurotransmitter secretion (GO:0046928)2.94106401
80regulation of neurotransmitter levels (GO:0001505)2.93760072
81regulation of voltage-gated calcium channel activity (GO:1901385)2.92769188
82long-term memory (GO:0007616)2.92395184
83synaptonemal complex organization (GO:0070193)2.92323162
84startle response (GO:0001964)2.91505316
85regulation of postsynaptic membrane potential (GO:0060078)2.91436267
86synaptic vesicle endocytosis (GO:0048488)2.90921041
87binding of sperm to zona pellucida (GO:0007339)2.90757685
88protein polyglutamylation (GO:0018095)2.89288609
89prepulse inhibition (GO:0060134)2.88808666
90microtubule-based movement (GO:0007018)2.88798392
91cell-cell recognition (GO:0009988)2.88483103
92reproduction (GO:0000003)2.87678050
93transmission of nerve impulse (GO:0019226)2.86453423
94cilium organization (GO:0044782)2.85931715
95proline transport (GO:0015824)2.85746845
96neurotransmitter-gated ion channel clustering (GO:0072578)2.85402819
97detection of calcium ion (GO:0005513)2.85004046
98regulation of synaptic transmission, glutamatergic (GO:0051966)2.84903628
99neuromuscular process controlling posture (GO:0050884)2.82515564
100membrane depolarization (GO:0051899)2.82300045
101regulation of centriole replication (GO:0046599)2.80720177
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80658354
103meiosis I (GO:0007127)2.80456990
104presynaptic membrane organization (GO:0097090)2.80354980
105membrane hyperpolarization (GO:0060081)2.79413420
106male meiosis I (GO:0007141)2.78806468
107regulation of microtubule-based movement (GO:0060632)2.78310452
108regulation of neurotransmitter transport (GO:0051588)2.78308461
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.78076583
110sperm capacitation (GO:0048240)2.76931973
111cilium assembly (GO:0042384)2.76621485
112regulation of inclusion body assembly (GO:0090083)2.75943972
113regulation of meiosis I (GO:0060631)2.69869157
114ketone body metabolic process (GO:1902224)2.62462857
115microtubule polymerization or depolymerization (GO:0031109)2.61976971
116C4-dicarboxylate transport (GO:0015740)2.61225584
117meiotic chromosome segregation (GO:0045132)2.59938106
118reciprocal DNA recombination (GO:0035825)2.55352472
119reciprocal meiotic recombination (GO:0007131)2.55352472
120cilium morphogenesis (GO:0060271)2.54813808
121postsynaptic membrane organization (GO:0001941)2.53482807
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50695477
123auditory behavior (GO:0031223)2.46797899
124resolution of meiotic recombination intermediates (GO:0000712)2.45741331
125positive regulation of dendritic spine morphogenesis (GO:0061003)2.40088647
126meiotic nuclear division (GO:0007126)2.37713139
127positive regulation of meiosis (GO:0045836)2.37451786
128primary amino compound metabolic process (GO:1901160)2.36878450
129centriole assembly (GO:0098534)2.34710153
130mechanosensory behavior (GO:0007638)2.33255005
131retinal cone cell development (GO:0046549)2.28918752
132meiotic cell cycle process (GO:1903046)2.28797145
133detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.27205143
134microtubule anchoring (GO:0034453)2.26399865
135positive regulation of meiotic cell cycle (GO:0051446)2.23140413
136synaptonemal complex assembly (GO:0007130)2.23124267
137fucose catabolic process (GO:0019317)2.22440893
138L-fucose metabolic process (GO:0042354)2.22440893
139L-fucose catabolic process (GO:0042355)2.22440893
140detection of light stimulus involved in visual perception (GO:0050908)2.21419613
141detection of light stimulus involved in sensory perception (GO:0050962)2.21419613
142establishment of protein localization to Golgi (GO:0072600)2.21362099
143protein import into peroxisome matrix (GO:0016558)2.20636534
144anterograde axon cargo transport (GO:0008089)2.18538077
145meiotic cell cycle (GO:0051321)2.17592760
146positive regulation of mitochondrial fission (GO:0090141)2.16822626
147serotonin metabolic process (GO:0042428)2.16803879
148regulation of DNA endoreduplication (GO:0032875)2.15951328
149water-soluble vitamin biosynthetic process (GO:0042364)2.14132266
150inner ear receptor stereocilium organization (GO:0060122)2.12806844
151righting reflex (GO:0060013)2.11136382
152regulation of centrosome cycle (GO:0046605)2.10729280
153spermatid nucleus differentiation (GO:0007289)2.10314858
154cellular component assembly involved in morphogenesis (GO:0010927)2.10172521
155regulation of centrosome duplication (GO:0010824)2.10049827
156protein K6-linked ubiquitination (GO:0085020)2.09738060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.92777397
2GBX2_23144817_ChIP-Seq_PC3_Human3.31846989
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50507638
4REST_21632747_ChIP-Seq_MESCs_Mouse2.38230054
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31718772
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26933157
7TAF15_26573619_Chip-Seq_HEK293_Human2.25227602
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20578767
9EWS_26573619_Chip-Seq_HEK293_Human2.13779699
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12625459
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.10065124
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08561815
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06605274
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06586805
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99782775
16DROSHA_22980978_ChIP-Seq_HELA_Human1.93319430
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93163512
18SMAD4_21799915_ChIP-Seq_A2780_Human1.93089823
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88191442
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86945840
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86179503
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82496088
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80182582
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.79282082
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78739833
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.78534653
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78110808
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77335054
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77018424
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75892671
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74846628
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74846628
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.74376160
34ZNF274_21170338_ChIP-Seq_K562_Hela1.73322658
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72688856
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71135394
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70222231
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.66996977
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.64276836
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.63023457
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60442349
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58443757
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58326603
44P300_19829295_ChIP-Seq_ESCs_Human1.56806763
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.51040273
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50666064
47VDR_22108803_ChIP-Seq_LS180_Human1.46936463
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.46725191
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46149113
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45737771
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.44809980
52RNF2_27304074_Chip-Seq_NSC_Mouse1.42429416
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40932058
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40076887
55* STAT3_23295773_ChIP-Seq_U87_Human1.39841358
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38041051
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34893037
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.34789821
59* TCF4_23295773_ChIP-Seq_U87_Human1.33987913
60FUS_26573619_Chip-Seq_HEK293_Human1.33891425
61ER_23166858_ChIP-Seq_MCF-7_Human1.32890461
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32738204
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32483422
64IGF1R_20145208_ChIP-Seq_DFB_Human1.31288738
65AR_25329375_ChIP-Seq_VCAP_Human1.31027922
66AR_21572438_ChIP-Seq_LNCaP_Human1.30799871
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30146781
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29926917
69* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29714271
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.28869392
71MYC_18940864_ChIP-ChIP_HL60_Human1.28773028
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27942182
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.27410394
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.25181423
75* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24539566
76* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22003883
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21456965
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.21372807
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20920629
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20470737
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19186817
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18000798
83* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17511773
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17430571
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.16448707
86* TCF4_22108803_ChIP-Seq_LS180_Human1.15218504
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14835901
88* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14757601
89* CBP_20019798_ChIP-Seq_JUKART_Human1.14757601
90TP53_22573176_ChIP-Seq_HFKS_Human1.14200288
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12986454
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12986454
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.12950426
94KDM2B_26808549_Chip-Seq_REH_Human1.11676213
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11149015
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11129808
97JUN_21703547_ChIP-Seq_K562_Human1.10826380
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.10249512
99* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10056706
100* BCAT_22108803_ChIP-Seq_LS180_Human1.09533964
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.09308156
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.08216680
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07508887
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07507006
105RUNX2_22187159_ChIP-Seq_PCA_Human1.07307589
106TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07210714
107P53_22387025_ChIP-Seq_ESCs_Mouse1.06929976
108* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06323046
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.05823022
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05317057
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05116783
112* TP53_18474530_ChIP-ChIP_U2OS_Human1.04339396
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.04270471
114CMYC_18555785_Chip-Seq_ESCs_Mouse1.03352674
115SMAD3_21741376_ChIP-Seq_ESCs_Human1.02986207
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.02953392
117SOX2_19829295_ChIP-Seq_ESCs_Human1.02286151
118NANOG_19829295_ChIP-Seq_ESCs_Human1.02286151
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01188087
120AR_19668381_ChIP-Seq_PC3_Human1.01006109
121TBL1_22424771_ChIP-Seq_293T_Human1.00841218
122SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00568918
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00399887
124KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00160606
125PRDM14_20953172_ChIP-Seq_ESCs_Human0.99552643
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99496624
127* ELK1_19687146_ChIP-ChIP_HELA_Human0.98393620
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98306260
129SOX9_26525672_Chip-Seq_HEART_Mouse0.95807170
130NFYB_21822215_ChIP-Seq_K562_Human0.93748504
131IRF1_19129219_ChIP-ChIP_H3396_Human0.92579479
132FOXA1_25329375_ChIP-Seq_VCAP_Human0.91937115
133FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91937115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.64648542
2MP0005410_abnormal_fertilization4.53740514
3MP0004859_abnormal_synaptic_plasticity4.50665496
4MP0009046_muscle_twitch3.67135856
5MP0003635_abnormal_synaptic_transmissio3.51441696
6MP0004270_analgesia3.24012399
7MP0009745_abnormal_behavioral_response3.07608386
8MP0002064_seizures2.95112337
9MP0001968_abnormal_touch/_nociception2.79979799
10MP0005423_abnormal_somatic_nervous2.76116430
11MP0002063_abnormal_learning/memory/cond2.68925521
12MP0002272_abnormal_nervous_system2.64168261
13MP0002572_abnormal_emotion/affect_behav2.52016470
14MP0002734_abnormal_mechanical_nocicepti2.36987906
15MP0001486_abnormal_startle_reflex2.35688161
16MP0005551_abnormal_eye_electrophysiolog2.34287130
17MP0001984_abnormal_olfaction2.27674744
18MP0000579_abnormal_nail_morphology2.26108824
19MP0002736_abnormal_nociception_after2.21907803
20MP0001501_abnormal_sleep_pattern2.19978371
21MP0002822_catalepsy2.12804719
22MP0001440_abnormal_grooming_behavior2.08657402
23MP0002067_abnormal_sensory_capabilities2.06293333
24MP0000569_abnormal_digit_pigmentation2.02044786
25MP0000566_synostosis2.00681124
26MP0002735_abnormal_chemical_nociception2.00025046
27* MP0003698_abnormal_male_reproductive1.97322553
28MP0008877_abnormal_DNA_methylation1.91690858
29MP0008569_lethality_at_weaning1.87328141
30MP0006276_abnormal_autonomic_nervous1.80301213
31MP0006292_abnormal_olfactory_placode1.77119847
32MP0002733_abnormal_thermal_nociception1.72958335
33MP0003329_amyloid_beta_deposits1.71334764
34MP0001970_abnormal_pain_threshold1.68596779
35MP0004924_abnormal_behavior1.66369964
36MP0005386_behavior/neurological_phenoty1.66369964
37MP0005646_abnormal_pituitary_gland1.62808624
38MP0002557_abnormal_social/conspecific_i1.59379266
39MP0000427_abnormal_hair_cycle1.57285329
40MP0001188_hyperpigmentation1.56964438
41MP0002909_abnormal_adrenal_gland1.56704843
42MP0006072_abnormal_retinal_apoptosis1.54067304
43MP0008058_abnormal_DNA_repair1.53730594
44MP0002184_abnormal_innervation1.51714151
45MP0001529_abnormal_vocalization1.49571577
46MP0000778_abnormal_nervous_system1.49098947
47MP0000383_abnormal_hair_follicle1.43815562
48MP0005253_abnormal_eye_physiology1.43668755
49MP0005623_abnormal_meninges_morphology1.42846640
50MP0004142_abnormal_muscle_tone1.41620611
51* MP0001929_abnormal_gametogenesis1.40667338
52MP0009780_abnormal_chondrocyte_physiolo1.39916781
53MP0003879_abnormal_hair_cell1.39906804
54MP0004811_abnormal_neuron_physiology1.39213346
55MP0001502_abnormal_circadian_rhythm1.38342452
56MP0002882_abnormal_neuron_morphology1.36731690
57MP0001905_abnormal_dopamine_level1.34381273
58MP0002229_neurodegeneration1.32132896
59MP0000955_abnormal_spinal_cord1.29655850
60MP0008057_abnormal_DNA_replication1.29333909
61MP0003718_maternal_effect1.29148276
62MP0003633_abnormal_nervous_system1.28687466
63MP0008789_abnormal_olfactory_epithelium1.28528347
64MP0005187_abnormal_penis_morphology1.28240061
65MP0002066_abnormal_motor_capabilities/c1.23915374
66MP0004858_abnormal_nervous_system1.18555228
67MP0010678_abnormal_skin_adnexa1.18554983
68MP0010094_abnormal_chromosome_stability1.18501884
69MP0004742_abnormal_vestibular_system1.18225912
70MP0003890_abnormal_embryonic-extraembry1.16533076
71MP0001485_abnormal_pinna_reflex1.14002150
72MP0002102_abnormal_ear_morphology1.13543008
73MP0003937_abnormal_limbs/digits/tail_de1.11884318
74MP0000647_abnormal_sebaceous_gland1.10261491
75MP0002938_white_spotting1.09926120
76MP0002653_abnormal_ependyma_morphology1.09856592
77MP0003631_nervous_system_phenotype1.07947611
78MP0005645_abnormal_hypothalamus_physiol1.07843211
79MP0002090_abnormal_vision1.07146290
80MP0003787_abnormal_imprinting1.05620064
81MP0004145_abnormal_muscle_electrophysio1.05030492
82MP0004885_abnormal_endolymph1.04772137
83MP0003634_abnormal_glial_cell1.02217388
84MP0003121_genomic_imprinting1.01521010
85MP0000653_abnormal_sex_gland0.99478490
86MP0001145_abnormal_male_reproductive0.99042511
87* MP0002161_abnormal_fertility/fecundity0.98833129
88MP0005389_reproductive_system_phenotype0.98002146
89MP0002152_abnormal_brain_morphology0.97939562
90MP0003136_yellow_coat_color0.97688062
91MP0001293_anophthalmia0.97611100
92MP0004133_heterotaxia0.97352482
93MP0005248_abnormal_Harderian_gland0.93310342
94MP0003693_abnormal_embryo_hatching0.93240968
95MP0008875_abnormal_xenobiotic_pharmacok0.92754824
96MP0004147_increased_porphyrin_level0.92520031
97MP0002752_abnormal_somatic_nervous0.91931406
98MP0000013_abnormal_adipose_tissue0.91223747
99MP0008872_abnormal_physiological_respon0.90890288
100MP0000026_abnormal_inner_ear0.89667576
101MP0004233_abnormal_muscle_weight0.88788994
102MP0000751_myopathy0.88681017
103MP0002837_dystrophic_cardiac_calcinosis0.88384728
104MP0004215_abnormal_myocardial_fiber0.85580266
105MP0001177_atelectasis0.85539358
106MP0002638_abnormal_pupillary_reflex0.84898803
107MP0000920_abnormal_myelination0.84522347
108MP0005391_vision/eye_phenotype0.82859741
109MP0002160_abnormal_reproductive_system0.82702812
110MP0003122_maternal_imprinting0.82663017
111MP0002876_abnormal_thyroid_physiology0.82651586
112MP0001963_abnormal_hearing_physiology0.82406907
113MP0003646_muscle_fatigue0.82359897
114MP0003119_abnormal_digestive_system0.81930702
115MP0001986_abnormal_taste_sensitivity0.81761512
116MP0000631_abnormal_neuroendocrine_gland0.81438685
117MP0002095_abnormal_skin_pigmentation0.80865856
118MP0001346_abnormal_lacrimal_gland0.80682987
119MP0002210_abnormal_sex_determination0.80611570
120MP0002928_abnormal_bile_duct0.79406853
121MP0002233_abnormal_nose_morphology0.79391561
122MP0003690_abnormal_glial_cell0.79156425
123MP0005195_abnormal_posterior_eye0.78437625
124MP0010386_abnormal_urinary_bladder0.77845995
125MP0003632_abnormal_nervous_system0.77390142
126MP0005535_abnormal_body_temperature0.74024546
127MP0005409_darkened_coat_color0.73882345
128MP0002234_abnormal_pharynx_morphology0.73725123
129MP0004085_abnormal_heartbeat0.73684752
130MP0003011_delayed_dark_adaptation0.73480819
131MP0002069_abnormal_eating/drinking_beha0.70117291
132MP0005499_abnormal_olfactory_system0.68697100
133MP0005394_taste/olfaction_phenotype0.68697100
134MP0008874_decreased_physiological_sensi0.66844085
135MP0000604_amyloidosis0.66161498
136MP0004043_abnormal_pH_regulation0.63960697

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.48611859
2Absent/shortened dynein arms (HP:0200106)7.91062100
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.91062100
4Abnormal respiratory motile cilium physiology (HP:0012261)7.73976853
5Abnormal ciliary motility (HP:0012262)7.25213625
6Abnormal respiratory motile cilium morphology (HP:0005938)6.28498649
7Abnormal respiratory epithelium morphology (HP:0012253)6.28498649
8Rhinitis (HP:0012384)5.98033854
9Focal motor seizures (HP:0011153)5.08104141
10Chronic bronchitis (HP:0004469)4.45792598
11Infertility (HP:0000789)3.90490445
12Progressive cerebellar ataxia (HP:0002073)3.74344792
13Pancreatic cysts (HP:0001737)3.55148085
14Epileptic encephalopathy (HP:0200134)3.54110101
15Focal seizures (HP:0007359)3.53978042
16Myokymia (HP:0002411)3.53818781
17Atonic seizures (HP:0010819)3.40427391
18Medial flaring of the eyebrow (HP:0010747)3.33053362
19Bronchiectasis (HP:0002110)3.24660499
20Gaze-evoked nystagmus (HP:0000640)3.15962999
21Chronic hepatic failure (HP:0100626)3.15180555
22Visual hallucinations (HP:0002367)3.14478116
23Nephronophthisis (HP:0000090)3.12599395
24Gait imbalance (HP:0002141)3.10375248
25Febrile seizures (HP:0002373)3.09904676
26Congenital primary aphakia (HP:0007707)2.94668049
27Absence seizures (HP:0002121)2.85493723
28Nasal polyposis (HP:0100582)2.81896039
29Central scotoma (HP:0000603)2.76936955
30Abnormality of macular pigmentation (HP:0008002)2.74932880
31Type II lissencephaly (HP:0007260)2.68659355
32Nephrogenic diabetes insipidus (HP:0009806)2.61512695
33Action tremor (HP:0002345)2.60647071
34Abnormality of the renal cortex (HP:0011035)2.55567829
35Oligodactyly (hands) (HP:0001180)2.50159124
36Dysdiadochokinesis (HP:0002075)2.49611190
37Hyperventilation (HP:0002883)2.45567300
38Generalized tonic-clonic seizures (HP:0002069)2.44335473
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43522859
40Abnormality of alanine metabolism (HP:0010916)2.43522859
41Hyperalaninemia (HP:0003348)2.43522859
42Dialeptic seizures (HP:0011146)2.43091566
43Abnormality of midbrain morphology (HP:0002418)2.42176275
44Molar tooth sign on MRI (HP:0002419)2.42176275
45Cystic liver disease (HP:0006706)2.41028525
46Genital tract atresia (HP:0001827)2.39475476
47Tubulointerstitial nephritis (HP:0001970)2.39187927
48Pancreatic fibrosis (HP:0100732)2.38101704
49Abnormality of the renal medulla (HP:0100957)2.37960347
50Truncal ataxia (HP:0002078)2.36614757
51Vaginal atresia (HP:0000148)2.36028472
52Supranuclear gaze palsy (HP:0000605)2.35560087
53Congenital stationary night blindness (HP:0007642)2.32725206
54Sclerocornea (HP:0000647)2.30353474
55Abnormality of the lower motor neuron (HP:0002366)2.29020989
56True hermaphroditism (HP:0010459)2.28913849
57Dyschromatopsia (HP:0007641)2.27275844
58Cerebellar dysplasia (HP:0007033)2.22280001
59Progressive inability to walk (HP:0002505)2.21520676
60Hemiparesis (HP:0001269)2.19845122
61Genetic anticipation (HP:0003743)2.19605680
62Tubular atrophy (HP:0000092)2.18555047
63Broad-based gait (HP:0002136)2.18330882
64Abnormality of ocular smooth pursuit (HP:0000617)2.17191592
65Poor coordination (HP:0002370)2.16972796
66Decreased central vision (HP:0007663)2.15849847
67Depression (HP:0000716)2.12678324
68Abnormality of the nasal mucosa (HP:0000433)2.12385001
69Postural instability (HP:0002172)2.12329547
70Dysmetria (HP:0001310)2.11561210
71Scanning speech (HP:0002168)2.10821369
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.10063893
73Bony spicule pigmentary retinopathy (HP:0007737)2.07863895
74Occipital encephalocele (HP:0002085)2.07049271
75Furrowed tongue (HP:0000221)2.03720914
76Hypoplastic labia majora (HP:0000059)2.02642965
77Limb dystonia (HP:0002451)2.02458616
78Bronchitis (HP:0012387)2.02444061
79Lissencephaly (HP:0001339)2.02069537
80Impaired vibration sensation in the lower limbs (HP:0002166)2.01547748
81Abnormal drinking behavior (HP:0030082)2.01275383
82Polydipsia (HP:0001959)2.01275383
83Neurofibrillary tangles (HP:0002185)2.00853335
84Impaired smooth pursuit (HP:0007772)2.00755344
85Urinary bladder sphincter dysfunction (HP:0002839)1.97701608
86Pheochromocytoma (HP:0002666)1.95262611
87Amyotrophic lateral sclerosis (HP:0007354)1.93437162
88Abnormal biliary tract physiology (HP:0012439)1.92998907
89Bile duct proliferation (HP:0001408)1.92998907
90Drooling (HP:0002307)1.92246455
91Aplasia/Hypoplasia of the lens (HP:0008063)1.91042197
92Specific learning disability (HP:0001328)1.88875010
93Ankle clonus (HP:0011448)1.87837250
94Abnormality of the labia minora (HP:0012880)1.87322673
95Dysmetric saccades (HP:0000641)1.86627933
96Anxiety (HP:0000739)1.84674782
97Attenuation of retinal blood vessels (HP:0007843)1.84593272
98Birth length less than 3rd percentile (HP:0003561)1.84563035
99Cerebral inclusion bodies (HP:0100314)1.82048215
100Scotoma (HP:0000575)1.81907941
101Choroideremia (HP:0001139)1.81544793
102Preaxial hand polydactyly (HP:0001177)1.80709645
103Renal cortical cysts (HP:0000803)1.80483911
104Anencephaly (HP:0002323)1.79503880
105Congenital hepatic fibrosis (HP:0002612)1.79414669
106Abnormality of saccadic eye movements (HP:0000570)1.78304098
107Abnormality of the labia majora (HP:0012881)1.78202921
108Chronic sinusitis (HP:0011109)1.77473118
109Abnormal eating behavior (HP:0100738)1.76934498
110Volvulus (HP:0002580)1.76868622
111Retinal dysplasia (HP:0007973)1.76080916
112Fair hair (HP:0002286)1.75899050
113Intention tremor (HP:0002080)1.75614489
114Epileptiform EEG discharges (HP:0011182)1.74991192
115Bradykinesia (HP:0002067)1.74098951
116Short tibia (HP:0005736)1.74002969
117Male infertility (HP:0003251)1.73944281
118Degeneration of the lateral corticospinal tracts (HP:0002314)1.73757395
119Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73757395
120Absent speech (HP:0001344)1.73044783
121Postaxial hand polydactyly (HP:0001162)1.71847308
122Abnormality of binocular vision (HP:0011514)1.71600982
123Diplopia (HP:0000651)1.71600982
124Retinitis pigmentosa (HP:0000510)1.70820553
125Postaxial foot polydactyly (HP:0001830)1.70802656
126Amblyopia (HP:0000646)1.70325195
127Recurrent sinusitis (HP:0011108)1.69876323
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.69645242
129Male pseudohermaphroditism (HP:0000037)1.69501077
130Neuroendocrine neoplasm (HP:0100634)1.69046155
131Poor eye contact (HP:0000817)1.68456897
132Spastic gait (HP:0002064)1.68251641
133Optic nerve hypoplasia (HP:0000609)1.68243688
134EEG with generalized epileptiform discharges (HP:0011198)1.68213931
135Inability to walk (HP:0002540)1.67670045
136Fragile nails (HP:0001808)1.67239834
137Impaired vibratory sensation (HP:0002495)1.66822723
138Aplasia/Hypoplasia of the uvula (HP:0010293)1.66326039
139Supernumerary spleens (HP:0009799)1.66298832
140Oligodactyly (HP:0012165)1.66112330
141Hypsarrhythmia (HP:0002521)1.65944492
142Insidious onset (HP:0003587)1.65748924
143Termporal pattern (HP:0011008)1.65748924
144Oculomotor apraxia (HP:0000657)1.65392074
145Abnormality of the corticospinal tract (HP:0002492)1.65178401
146Abnormality of nail color (HP:0100643)1.64457438
147Esophageal atresia (HP:0002032)1.63463896
148Gastrointestinal atresia (HP:0002589)1.62817279
149Chromsome breakage (HP:0040012)1.62597605
150Excessive salivation (HP:0003781)1.60243824
151Multicystic kidney dysplasia (HP:0000003)1.60181541
152Onycholysis (HP:0001806)1.59978055
153Labial hypoplasia (HP:0000066)1.58878700
154Aganglionic megacolon (HP:0002251)1.58644890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.27712449
2PDK44.27712449
3PNCK3.79243790
4NTRK33.47134072
5FRK3.22537593
6MAP3K42.81811943
7MAP2K72.64245425
8PDK22.57139167
9CASK2.52094384
10EPHA42.45714480
11PRKD32.33701222
12MAP3K122.32272917
13MINK12.25080284
14MAP3K92.24998411
15BMPR1B2.22540509
16ZAK1.82153116
17PLK41.81130686
18STK391.80218032
19TNIK1.79786983
20RIPK41.79193935
21NTRK21.73730131
22MAP2K41.73713798
23STK381.63668744
24INSRR1.62352167
25PLK21.61517352
26MARK11.61011523
27PTK2B1.59107003
28CAMKK21.57270749
29WNK41.55998236
30PAK61.55629319
31WEE11.51658819
32WNK11.50783933
33CAMKK11.49042462
34STK38L1.47380193
35DAPK21.44419491
36TSSK61.44395753
37MAP4K21.43820671
38NTRK11.42975920
39GRK51.41526967
40ERBB31.34961975
41ADRBK21.34804283
42MET1.33082142
43SRPK11.27478033
44CDK191.24060603
45TTK1.20744996
46TRIM281.18770976
47PRKCG1.18510441
48CDK51.16102107
49BRD41.15915502
50BRSK21.15664547
51PINK11.10247405
52MKNK21.10047865
53BUB11.09599313
54TESK11.08113639
55MAPKAPK51.06355862
56CAMK2A1.05865396
57OXSR11.04570845
58TLK11.02233567
59MUSK1.01976132
60EIF2AK31.00968619
61SGK4940.98734957
62SGK2230.98734957
63ARAF0.95981697
64PLK30.95001107
65MAPK130.94072000
66MAPK150.92669171
67PLK10.92523284
68NUAK10.92304326
69LMTK20.91040066
70CSNK1A1L0.90577897
71CSNK1G30.90456848
72CSNK1G10.88725742
73CAMK2B0.88260580
74MST1R0.88112993
75MAP3K20.85536965
76ACVR1B0.85263952
77SGK20.83304518
78NEK10.82979483
79TGFBR10.81465086
80CAMK1G0.81229868
81CDC70.81058102
82GRK70.80527886
83PDK10.80091716
84KSR20.77779189
85FES0.76622641
86CAMK2D0.76234299
87DAPK10.76152135
88BMPR20.75292614
89CHEK20.74102810
90MKNK10.73926571
91KSR10.73330362
92UHMK10.71859425
93VRK10.71116691
94ICK0.70490951
95CAMK10.69056245
96CDK180.67372278
97BRSK10.67081565
98PBK0.65972935
99CSNK1G20.65719216
100TYRO30.64859531
101CDK140.63809310
102PHKG20.63794722
103PHKG10.63794722
104CDK150.63564017
105LATS10.63531338
106TNK20.62863074
107NEK20.62463195
108STK110.61895947
109AKT30.61868321
110NEK60.61314385
111BCR0.60362259
112STK160.60004556
113ATM0.59000894
114ATR0.58211110
115CSNK1E0.58200383
116SGK10.56748596
117PRKCH0.55984831
118CCNB10.55667284
119PRKCE0.55365453
120PAK30.54199058
121CAMK2G0.53896285
122PIM20.53330135
123CDK11A0.52978980
124SGK30.52769286
125FER0.52756177
126DYRK1A0.51235275
127PRKCI0.50143367
128EPHB20.50067612
129SIK20.49670037
130PDPK10.48822107
131PKN10.47184987
132RPS6KA50.45709103
133CSNK1A10.42825386
134RET0.42645063
135MAP3K10.42278769
136CDK10.42275388
137RPS6KA30.41639050
138STK30.40680022
139ROCK20.39924082
140WNK30.39900851
141MAPK100.39058774
142PRPF4B0.38616733
143PRKG10.38207883
144ADRBK10.37675776
145MAP3K130.37270562
146GRK10.36249625
147PRKACA0.35882402
148SIK30.35395002
149CDK30.34494971
150IRAK20.32766256
151PRKCB0.32294683
152CDC42BPA0.28643812

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.83199793
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36755600
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76489906
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60750130
5Phototransduction_Homo sapiens_hsa047442.60188333
6Olfactory transduction_Homo sapiens_hsa047402.58333396
7GABAergic synapse_Homo sapiens_hsa047272.58098166
8Amphetamine addiction_Homo sapiens_hsa050312.56551179
9Circadian entrainment_Homo sapiens_hsa047132.49520372
10Long-term potentiation_Homo sapiens_hsa047202.48989688
11Morphine addiction_Homo sapiens_hsa050322.36554281
12Glutamatergic synapse_Homo sapiens_hsa047242.36115547
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16046745
14Salivary secretion_Homo sapiens_hsa049702.08636297
15Dopaminergic synapse_Homo sapiens_hsa047282.08561240
16Protein export_Homo sapiens_hsa030602.02077697
17Nitrogen metabolism_Homo sapiens_hsa009102.02010312
18Butanoate metabolism_Homo sapiens_hsa006502.01397088
19Collecting duct acid secretion_Homo sapiens_hsa049661.98743629
20Insulin secretion_Homo sapiens_hsa049111.96747783
21Taste transduction_Homo sapiens_hsa047421.94614701
22Renin secretion_Homo sapiens_hsa049241.92964517
23Fanconi anemia pathway_Homo sapiens_hsa034601.83912364
24Gastric acid secretion_Homo sapiens_hsa049711.77183908
25Serotonergic synapse_Homo sapiens_hsa047261.73014337
26Homologous recombination_Homo sapiens_hsa034401.70966436
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69430873
28Cocaine addiction_Homo sapiens_hsa050301.68675818
29Basal transcription factors_Homo sapiens_hsa030221.68473201
30Selenocompound metabolism_Homo sapiens_hsa004501.68295571
31Cholinergic synapse_Homo sapiens_hsa047251.62789216
32Long-term depression_Homo sapiens_hsa047301.62595231
33Calcium signaling pathway_Homo sapiens_hsa040201.62583696
34Propanoate metabolism_Homo sapiens_hsa006401.61889962
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59576138
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59441366
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50908577
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44677573
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43898690
40Dorso-ventral axis formation_Homo sapiens_hsa043201.43317610
41Oxytocin signaling pathway_Homo sapiens_hsa049211.42948021
42Cardiac muscle contraction_Homo sapiens_hsa042601.35472468
43Non-homologous end-joining_Homo sapiens_hsa034501.34979349
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28976448
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.26511431
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25433689
47RNA transport_Homo sapiens_hsa030131.24371769
48Linoleic acid metabolism_Homo sapiens_hsa005911.23926146
49RNA polymerase_Homo sapiens_hsa030201.23797620
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22813520
51cAMP signaling pathway_Homo sapiens_hsa040241.22093822
52RNA degradation_Homo sapiens_hsa030181.22020957
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21989641
54One carbon pool by folate_Homo sapiens_hsa006701.21714235
55Steroid biosynthesis_Homo sapiens_hsa001001.21425610
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17582251
57Vibrio cholerae infection_Homo sapiens_hsa051101.14798076
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10784371
59Estrogen signaling pathway_Homo sapiens_hsa049151.09734308
60Nucleotide excision repair_Homo sapiens_hsa034201.09337642
61Gap junction_Homo sapiens_hsa045401.08597115
62GnRH signaling pathway_Homo sapiens_hsa049121.08201738
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07477066
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04352571
65Glucagon signaling pathway_Homo sapiens_hsa049221.03811171
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03446885
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99359600
68Oocyte meiosis_Homo sapiens_hsa041140.97381386
69Mismatch repair_Homo sapiens_hsa034300.93172397
70Thyroid hormone synthesis_Homo sapiens_hsa049180.93125574
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88905591
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.88744609
73Oxidative phosphorylation_Homo sapiens_hsa001900.88457547
74Huntingtons disease_Homo sapiens_hsa050160.88146912
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87791833
76Pancreatic secretion_Homo sapiens_hsa049720.85948377
77Cell cycle_Homo sapiens_hsa041100.84530385
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.82457220
79Alzheimers disease_Homo sapiens_hsa050100.82171224
80Fatty acid biosynthesis_Homo sapiens_hsa000610.81711265
81Type II diabetes mellitus_Homo sapiens_hsa049300.81326938
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81227992
83Pyruvate metabolism_Homo sapiens_hsa006200.80790876
84Peroxisome_Homo sapiens_hsa041460.79791215
85Melanogenesis_Homo sapiens_hsa049160.79714865
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74740490
87beta-Alanine metabolism_Homo sapiens_hsa004100.74141441
88ABC transporters_Homo sapiens_hsa020100.73286083
89Tryptophan metabolism_Homo sapiens_hsa003800.73126986
90Inositol phosphate metabolism_Homo sapiens_hsa005620.72590491
91p53 signaling pathway_Homo sapiens_hsa041150.71653601
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71378420
93Caffeine metabolism_Homo sapiens_hsa002320.70793697
94Axon guidance_Homo sapiens_hsa043600.70729650
95Circadian rhythm_Homo sapiens_hsa047100.68443456
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67604063
97Hedgehog signaling pathway_Homo sapiens_hsa043400.67578516
98Purine metabolism_Homo sapiens_hsa002300.67346436
99Arginine and proline metabolism_Homo sapiens_hsa003300.66638126
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65020644
101Alcoholism_Homo sapiens_hsa050340.62677508
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61301577
103Glioma_Homo sapiens_hsa052140.61253680
104ErbB signaling pathway_Homo sapiens_hsa040120.60982186
105Parkinsons disease_Homo sapiens_hsa050120.60473226
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60438980
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60190951
108Hippo signaling pathway_Homo sapiens_hsa043900.59532842
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59224772
110Folate biosynthesis_Homo sapiens_hsa007900.59124095
111Mineral absorption_Homo sapiens_hsa049780.58723694
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58108780
113Dilated cardiomyopathy_Homo sapiens_hsa054140.57819990
114mRNA surveillance pathway_Homo sapiens_hsa030150.57660113
115Metabolic pathways_Homo sapiens_hsa011000.57651304
116MAPK signaling pathway_Homo sapiens_hsa040100.56869277
117Vitamin B6 metabolism_Homo sapiens_hsa007500.56547541
118Regulation of autophagy_Homo sapiens_hsa041400.56217800
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54021716
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.53923945
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51627680
122Fatty acid metabolism_Homo sapiens_hsa012120.51542338
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.51356329
124Type I diabetes mellitus_Homo sapiens_hsa049400.51239957
125Pyrimidine metabolism_Homo sapiens_hsa002400.49572665
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.48718086
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48419189
128DNA replication_Homo sapiens_hsa030300.46461441
129Rheumatoid arthritis_Homo sapiens_hsa053230.45588754
130Sulfur relay system_Homo sapiens_hsa041220.45470612
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44851735
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42443202
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41334877
134Ovarian steroidogenesis_Homo sapiens_hsa049130.41032176
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40219138
136Choline metabolism in cancer_Homo sapiens_hsa052310.38744409
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38686579
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37892347
139Endocytosis_Homo sapiens_hsa041440.37046049
140Wnt signaling pathway_Homo sapiens_hsa043100.36912171
141Ras signaling pathway_Homo sapiens_hsa040140.36742552
142Ether lipid metabolism_Homo sapiens_hsa005650.35716665
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.35383253
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35271916
145Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34059789
146VEGF signaling pathway_Homo sapiens_hsa043700.33767643
147Bile secretion_Homo sapiens_hsa049760.33247571
148African trypanosomiasis_Homo sapiens_hsa051430.31715518
149Glycerolipid metabolism_Homo sapiens_hsa005610.29306195
150Phagosome_Homo sapiens_hsa041450.28996362
151Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27562796
152Rap1 signaling pathway_Homo sapiens_hsa040150.23623366

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