HSPA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* activation of signaling protein activity involved in unfolded protein response (GO:0006987)6.61856248
2* maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.58571945
3protein retention in ER lumen (GO:0006621)6.58571945
4sequestering of metal ion (GO:0051238)6.49927302
5* positive regulation of nuclease activity (GO:0032075)6.40578519
6COPII vesicle coating (GO:0048208)6.24754855
7* regulation of nuclease activity (GO:0032069)5.93481260
8* endoplasmic reticulum unfolded protein response (GO:0030968)5.87220381
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.81199230
10* cellular response to unfolded protein (GO:0034620)5.70573820
11* ER-nucleus signaling pathway (GO:0006984)5.41514489
12signal peptide processing (GO:0006465)5.38271373
13* cellular response to topologically incorrect protein (GO:0035967)5.36508806
14protein maturation by protein folding (GO:0022417)5.16587154
15hemidesmosome assembly (GO:0031581)4.91998507
16* response to endoplasmic reticulum stress (GO:0034976)4.80283427
17vesicle coating (GO:0006901)4.76316076
18* ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.59296438
19* response to unfolded protein (GO:0006986)4.56515616
20* response to topologically incorrect protein (GO:0035966)4.33596472
21protein N-linked glycosylation via asparagine (GO:0018279)4.25268839
22peptidyl-asparagine modification (GO:0018196)4.23266816
23exocrine pancreas development (GO:0031017)4.17455049
24apoptotic cell clearance (GO:0043277)4.08865683
25cellular response to ATP (GO:0071318)4.01431175
26protein N-linked glycosylation (GO:0006487)3.86498630
27regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.86030979
284-hydroxyproline metabolic process (GO:0019471)3.82160754
29desmosome organization (GO:0002934)3.81380929
30UDP-N-acetylglucosamine metabolic process (GO:0006047)3.65373029
31cellular copper ion homeostasis (GO:0006878)3.57478106
32* ER overload response (GO:0006983)3.40893434
33endocrine pancreas development (GO:0031018)3.40263456
34peptide hormone processing (GO:0016486)3.39335350
35folic acid-containing compound biosynthetic process (GO:0009396)3.29276619
36peptide catabolic process (GO:0043171)3.29242671
37type B pancreatic cell development (GO:0003323)3.28853086
38cellular response to vitamin D (GO:0071305)3.28479295
39nuclear pore organization (GO:0006999)3.22914055
40ER to Golgi vesicle-mediated transport (GO:0006888)3.22551902
41regulation of translational termination (GO:0006449)3.21151508
42protein localization to endosome (GO:0036010)3.21043924
43ribosome assembly (GO:0042255)3.17845049
44bundle of His cell to Purkinje myocyte communication (GO:0086069)3.15578279
45cell-substrate junction assembly (GO:0007044)3.08742698
46mesodermal cell differentiation (GO:0048333)3.06182037
47chaperone mediated protein folding requiring cofactor (GO:0051085)3.03450407
48positive regulation of p38MAPK cascade (GO:1900745)3.02932880
49Golgi organization (GO:0007030)3.01072995
50cell redox homeostasis (GO:0045454)2.97511209
51pore complex assembly (GO:0046931)2.97342107
52peptidyl-proline hydroxylation (GO:0019511)2.95812657
53chaperone-mediated protein folding (GO:0061077)2.93317106
54glucocorticoid receptor signaling pathway (GO:0042921)2.89786742
55glandular epithelial cell development (GO:0002068)2.88404175
56glandular epithelial cell differentiation (GO:0002067)2.87929024
57regulation of RNA export from nucleus (GO:0046831)2.86099192
58regulation of mitotic spindle organization (GO:0060236)2.85740420
59regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.85172619
60L-serine transport (GO:0015825)2.84402967
61skin morphogenesis (GO:0043589)2.84102273
62protein hydroxylation (GO:0018126)2.84085585
63tRNA aminoacylation for protein translation (GO:0006418)2.79159828
64cellular response to vitamin (GO:0071295)2.78758836
65regulation of nucleobase-containing compound transport (GO:0032239)2.77889670
66endodermal cell differentiation (GO:0035987)2.76156048
67cell adhesion mediated by integrin (GO:0033627)2.75941111
68serine transport (GO:0032329)2.75469357
69negative regulation of fatty acid transport (GO:2000192)2.69977555
70regulation of cholesterol homeostasis (GO:2000188)2.69371205
71antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.68589166
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.68589166
73positive regulation of osteoblast proliferation (GO:0033690)2.65690940
74regulation of type B pancreatic cell apoptotic process (GO:2000674)2.65236217
75L-alpha-amino acid transmembrane transport (GO:1902475)2.63723269
76protein export from nucleus (GO:0006611)2.63582399
77keratan sulfate catabolic process (GO:0042340)2.63385450
78membrane protein ectodomain proteolysis (GO:0006509)2.63074980
79protein autoprocessing (GO:0016540)2.62798380
80intra-Golgi vesicle-mediated transport (GO:0006891)2.62624747
81negative regulation of fibrinolysis (GO:0051918)2.62016549
82regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.60543228
83tRNA aminoacylation (GO:0043039)2.60540393
84amino acid activation (GO:0043038)2.60540393
85antigen processing and presentation of endogenous antigen (GO:0019883)2.60471341
86mitotic chromosome condensation (GO:0007076)2.59743972
87iron ion import (GO:0097286)2.57620589
88lung vasculature development (GO:0060426)2.55999584
89basement membrane organization (GO:0071711)2.55179113
90collagen fibril organization (GO:0030199)2.54861736
91negative regulation of bone resorption (GO:0045779)2.54712919
92columnar/cuboidal epithelial cell development (GO:0002066)2.53556709
93negative regulation of glycoprotein biosynthetic process (GO:0010561)2.53449722
94hyaluronan catabolic process (GO:0030214)2.49941189
95formation of translation preinitiation complex (GO:0001731)2.48252741
96trophoblast giant cell differentiation (GO:0060707)2.47716030
97regulation of transforming growth factor beta2 production (GO:0032909)2.47332655
98gap junction assembly (GO:0016264)2.45547322
99epithelial cell-cell adhesion (GO:0090136)2.45248344
100pinocytosis (GO:0006907)2.45097402
101mammary gland epithelial cell proliferation (GO:0033598)2.44800306
102wound healing, spreading of epidermal cells (GO:0035313)2.42971903
103chondrocyte proliferation (GO:0035988)2.41398679
104dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.41248237
105negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.40765470
106positive regulation of hormone biosynthetic process (GO:0046886)2.40637193
107response to testosterone (GO:0033574)2.40221793
108nucleotide-sugar biosynthetic process (GO:0009226)2.37974118
109branching involved in mammary gland duct morphogenesis (GO:0060444)2.37875007
110hepatocyte differentiation (GO:0070365)2.37582940
111corticosteroid receptor signaling pathway (GO:0031958)2.36752316
112intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.36168305
113spliceosomal tri-snRNP complex assembly (GO:0000244)2.34376964
114positive regulation of DNA-templated transcription, initiation (GO:2000144)2.33916323
115chondrocyte development (GO:0002063)2.33797408
116hypotonic response (GO:0006971)2.33795377
117positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.33732384
118maternal placenta development (GO:0001893)2.33727026
119copper ion homeostasis (GO:0055070)2.33237540
120positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.33236978
121cell migration involved in sprouting angiogenesis (GO:0002042)2.28316001
122regulation of translational fidelity (GO:0006450)2.27809524
123regulation of transforming growth factor beta1 production (GO:0032908)2.27755043
124nuclear pore complex assembly (GO:0051292)2.27567599
125surfactant homeostasis (GO:0043129)2.27528869
126cellular zinc ion homeostasis (GO:0006882)2.27374716
127glucose 6-phosphate metabolic process (GO:0051156)2.26918616
128mitotic nuclear envelope reassembly (GO:0007084)2.26786921
129nuclear envelope reassembly (GO:0031468)2.26786921
130macroautophagy (GO:0016236)2.26759655
131cell-substrate adherens junction assembly (GO:0007045)2.26561489
132positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.24750680
133negative regulation of bone remodeling (GO:0046851)2.23876661
134hormone catabolic process (GO:0042447)2.23423900
135intestinal epithelial cell development (GO:0060576)2.23094678
136dorsal/ventral axis specification (GO:0009950)2.20637606
137positive regulation of glycoprotein metabolic process (GO:1903020)2.20110196
138mRNA transcription (GO:0009299)2.19292916
139JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.16465125
140cellular response to nutrient (GO:0031670)2.14939686
141Golgi vesicle transport (GO:0048193)2.14321819
142proline biosynthetic process (GO:0006561)2.13392641
143toxin metabolic process (GO:0009404)2.12777373
144wound healing, spreading of cells (GO:0044319)2.12704070
145regulation of membrane protein ectodomain proteolysis (GO:0051043)2.11724248
146protein folding (GO:0006457)2.11632078
147insulin-like growth factor receptor signaling pathway (GO:0048009)2.09762916
148tetrahydrofolate metabolic process (GO:0046653)2.09636163
149decidualization (GO:0046697)2.08430182
150negative regulation of glycoprotein metabolic process (GO:1903019)2.07318010
151COPI coating of Golgi vesicle (GO:0048205)10.7221054
152Golgi transport vesicle coating (GO:0048200)10.7221054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.05936421
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.62429734
3* CLOCK_20551151_ChIP-Seq_293T_Human3.57969152
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.45777752
5ZNF263_19887448_ChIP-Seq_K562_Human3.37482565
6GATA1_22025678_ChIP-Seq_K562_Human2.92152205
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.83538780
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.71432332
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.57311327
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.51615133
11DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.20095184
12E2F7_22180533_ChIP-Seq_HELA_Human2.13400536
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.08914240
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.02260670
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00114614
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93156179
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.90122807
18SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.87589492
19HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85768829
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.85289132
21TFEB_21752829_ChIP-Seq_HELA_Human1.83124737
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77359550
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77306303
24MYC_22102868_ChIP-Seq_BL_Human1.71579062
25* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68729644
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68353547
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65107191
28* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62120907
29* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60494190
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.57040049
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56779419
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.55420692
33* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55270490
34* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54786235
35* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54470454
36DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52645224
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.51904910
38ELK1_19687146_ChIP-ChIP_HELA_Human1.51485493
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50225426
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48913931
41* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48230597
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48220971
43AR_21909140_ChIP-Seq_LNCAP_Human1.46393233
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46101301
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44108401
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43638971
47* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43113044
48* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43113044
49* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42994728
50* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41759600
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40992914
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40764256
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40633651
54NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.40481578
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40135768
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40064965
57CHD1_26751641_Chip-Seq_LNCaP_Human1.39500843
58* ATF3_27146783_Chip-Seq_COLON_Human1.39396963
59* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38951557
60FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.38773960
61* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37272368
62* BRD4_25478319_ChIP-Seq_HGPS_Human1.37058281
63* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36952183
64* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35989067
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35149718
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33351814
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33277944
68* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32647930
69* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32563115
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31603457
71* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31601410
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31287304
73* SOX2_20726797_ChIP-Seq_SW620_Human1.29108226
74GATA6_25053715_ChIP-Seq_YYC3_Human1.28963640
75* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28331959
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27653278
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.26115471
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26075978
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26048762
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25597950
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23746224
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.20830312
83XRN2_22483619_ChIP-Seq_HELA_Human1.20274329
84RACK7_27058665_Chip-Seq_MCF-7_Human1.19899941
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18770634
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16911860
87GATA4_25053715_ChIP-Seq_YYC3_Human1.15330431
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15197660
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14656221
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14583746
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14349361
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13603633
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13427878
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12897644
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.12621928
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11978041
97* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11877297
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11145495
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11086224
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10562842
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10343053
102ESR2_21235772_ChIP-Seq_MCF-7_Human1.09359511
103MYC_18555785_ChIP-Seq_MESCs_Mouse1.08086258
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07973658
105EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07763114
106E2F1_21310950_ChIP-Seq_MCF-7_Human1.06991207
107SOX17_20123909_ChIP-Seq_XEN_Mouse1.05504011
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05496865
109DCP1A_22483619_ChIP-Seq_HELA_Human1.05492609
110* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05468140
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04586628
112* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04193676
113MYB_26560356_Chip-Seq_TH2_Human1.04159516
114* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03977881
115ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03807301
116* GATA3_24758297_ChIP-Seq_MCF-7_Human1.03774007
117ELK3_25401928_ChIP-Seq_HUVEC_Human1.02186147
118MYB_26560356_Chip-Seq_TH1_Human1.01459854
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01008998
120NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00507425
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00494653
122* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99418187
123* CJUN_26792858_Chip-Seq_BT549_Human0.98953546
124SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98390484
125MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97160034
126* NCOR1_26117541_ChIP-Seq_K562_Human0.96520201
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96288862
128GABP_17652178_ChIP-ChIP_JURKAT_Human0.95388095
129PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95343316
130SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94441495
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92901345
132* KDM5A_27292631_Chip-Seq_BREAST_Human0.92679549
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.92626415
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.92619416
135GABP_19822575_ChIP-Seq_HepG2_Human0.91955909
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89750706
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.88939228
138* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88329704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.79716188
2MP0008438_abnormal_cutaneous_collagen3.78401914
3MP0006054_spinal_hemorrhage2.96035564
4MP0003705_abnormal_hypodermis_morpholog2.90431300
5MP0003950_abnormal_plasma_membrane2.79656439
6MP0003300_gastrointestinal_ulcer2.76529645
7MP0010352_gastrointestinal_tract_polyps2.55754649
8MP0003941_abnormal_skin_development2.45838809
9MP0000579_abnormal_nail_morphology2.38351570
10MP0005076_abnormal_cell_differentiation2.34480396
11MP0005220_abnormal_exocrine_pancreas2.27264905
12MP0003283_abnormal_digestive_organ2.21709327
13MP0003566_abnormal_cell_adhesion2.19149969
14MP0005275_abnormal_skin_tensile2.07539939
15MP0004264_abnormal_extraembryonic_tissu2.01272575
16MP0000013_abnormal_adipose_tissue1.98408476
17MP0001944_abnormal_pancreas_morphology1.94691775
18MP0005623_abnormal_meninges_morphology1.94150852
19MP0002693_abnormal_pancreas_physiology1.90568584
20MP0004272_abnormal_basement_membrane1.86690406
21MP0009780_abnormal_chondrocyte_physiolo1.85905335
22MP0010234_abnormal_vibrissa_follicle1.84755717
23MP0002896_abnormal_bone_mineralization1.76307561
24MP0002796_impaired_skin_barrier1.76236125
25MP0009840_abnormal_foam_cell1.75753294
26MP0004233_abnormal_muscle_weight1.73839144
27MP0003183_abnormal_peptide_metabolism1.69393103
28MP0001216_abnormal_epidermal_layer1.62554289
29* MP0004957_abnormal_blastocyst_morpholog1.61465704
30MP0003195_calcinosis1.60959391
31MP0003453_abnormal_keratinocyte_physiol1.58183634
32MP0005503_abnormal_tendon_morphology1.53495141
33MP0005451_abnormal_body_composition1.51965121
34MP0001849_ear_inflammation1.50810961
35MP0005023_abnormal_wound_healing1.50178095
36MP0005501_abnormal_skin_physiology1.50138808
37MP0001730_embryonic_growth_arrest1.46394535
38MP0003111_abnormal_nucleus_morphology1.45770033
39MP0000762_abnormal_tongue_morphology1.45263618
40MP0003656_abnormal_erythrocyte_physiolo1.45027901
41MP0005058_abnormal_lysosome_morphology1.43777458
42MP0000467_abnormal_esophagus_morphology1.38573552
43MP0003252_abnormal_bile_duct1.37858855
44MP0002166_altered_tumor_susceptibility1.32066427
45MP0009384_cardiac_valve_regurgitation1.29753477
46MP0000003_abnormal_adipose_tissue1.29463976
47MP0004043_abnormal_pH_regulation1.27034857
48MP0002060_abnormal_skin_morphology1.25134846
49MP0002928_abnormal_bile_duct1.23478515
50MP0010678_abnormal_skin_adnexa1.20597872
51* MP0008932_abnormal_embryonic_tissue1.20420687
52MP0001915_intracranial_hemorrhage1.20383357
53MP0002138_abnormal_hepatobiliary_system1.20222808
54MP0000678_abnormal_parathyroid_gland1.19333959
55MP0000350_abnormal_cell_proliferation1.16614562
56MP0002909_abnormal_adrenal_gland1.15870734
57MP0010307_abnormal_tumor_latency1.15657683
58* MP0002080_prenatal_lethality1.12540570
59MP0001853_heart_inflammation1.11845846
60MP0000627_abnormal_mammary_gland1.11587333
61MP0001672_abnormal_embryogenesis/_devel1.11489262
62MP0005380_embryogenesis_phenotype1.11489262
63MP0001533_abnormal_skeleton_physiology1.11009419
64MP0001697_abnormal_embryo_size1.09979501
65MP0003795_abnormal_bone_structure1.09724756
66MP0009643_abnormal_urine_homeostasis1.08873809
67MP0009053_abnormal_anal_canal1.08823536
68MP0005257_abnormal_intraocular_pressure1.08643261
69MP0010386_abnormal_urinary_bladder1.08484924
70MP0003279_aneurysm1.08407840
71MP0003984_embryonic_growth_retardation1.07291547
72MP0003436_decreased_susceptibility_to1.04993010
73MP0003091_abnormal_cell_migration1.03112785
74MP0003890_abnormal_embryonic-extraembry1.01736500
75MP0002098_abnormal_vibrissa_morphology1.01393231
76MP0001958_emphysema1.00500364
77MP0005165_increased_susceptibility_to0.99963619
78MP0005384_cellular_phenotype0.99644702
79MP0005197_abnormal_uvea_morphology0.98831477
80* MP0009931_abnormal_skin_appearance0.98516624
81MP0003191_abnormal_cellular_cholesterol0.98081301
82MP0010771_integument_phenotype0.97986563
83MP0003077_abnormal_cell_cycle0.97453717
84MP0003303_peritoneal_inflammation0.96703877
85MP0005310_abnormal_salivary_gland0.96681536
86MP0008260_abnormal_autophagy0.96085934
87MP0004858_abnormal_nervous_system0.95323043
88MP0002078_abnormal_glucose_homeostasis0.93992960
89MP0005508_abnormal_skeleton_morphology0.93696046
90MP0004947_skin_inflammation0.93408153
91MP0002139_abnormal_hepatobiliary_system0.93368452
92MP0002089_abnormal_postnatal_growth/wei0.92851660
93MP0000537_abnormal_urethra_morphology0.91593469
94MP0000377_abnormal_hair_follicle0.91031102
95MP0002084_abnormal_developmental_patter0.90820795
96MP0000383_abnormal_hair_follicle0.90470078
97MP0003045_fibrosis0.90380173
98MP0001243_abnormal_dermal_layer0.90015066
99MP0005390_skeleton_phenotype0.89894906
100MP0003806_abnormal_nucleotide_metabolis0.89640754
101MP0005409_darkened_coat_color0.89302583
102MP0000613_abnormal_salivary_gland0.88915416
103MP0001756_abnormal_urination0.88797219
104MP0010368_abnormal_lymphatic_system0.88652246
105MP0003172_abnormal_lysosome_physiology0.87966340
106MP0005365_abnormal_bile_salt0.85317596
107MP0005408_hypopigmentation0.84560252
108MP0001299_abnormal_eye_distance/0.84554743
109MP0003329_amyloid_beta_deposits0.82552425
110MP0003868_abnormal_feces_composition0.81883640
111MP0002085_abnormal_embryonic_tissue0.81737567
112MP0003122_maternal_imprinting0.81670940
113MP0003448_altered_tumor_morphology0.81015243
114* MP0003693_abnormal_embryo_hatching0.80885093
115MP0004185_abnormal_adipocyte_glucose0.80585709
116MP0003221_abnormal_cardiomyocyte_apopto0.80516053
117MP0000858_altered_metastatic_potential0.80357204
118MP0001666_abnormal_nutrient_absorption0.80117080
119MP0001191_abnormal_skin_condition0.80044092
120MP0003115_abnormal_respiratory_system0.79958503
121MP0003959_abnormal_lean_body0.79832603
122MP0000566_synostosis0.78764023
123MP0003385_abnormal_body_wall0.78589839
124MP0002933_joint_inflammation0.78454498
125MP0000767_abnormal_smooth_muscle0.77636344
126MP0002998_abnormal_bone_remodeling0.77274877
127MP0003123_paternal_imprinting0.77161689
128* MP0005164_abnormal_response_to0.76683561
129MP0009697_abnormal_copulation0.76302622
130MP0001661_extended_life_span0.76138895
131MP0002168_other_aberrant_phenotype0.75949878
132MP0002234_abnormal_pharynx_morphology0.75575160
133MP0002925_abnormal_cardiovascular_devel0.74165750
134MP0000609_abnormal_liver_physiology0.73939230
135MP0010094_abnormal_chromosome_stability0.73651482
136MP0002006_tumorigenesis0.73515417
137MP0001879_abnormal_lymphatic_vessel0.73487745
138MP0000163_abnormal_cartilage_morphology0.73299178
139MP0001845_abnormal_inflammatory_respons0.72830006
140MP0000428_abnormal_craniofacial_morphol0.69044113
141MP0000598_abnormal_liver_morphology0.67931182
142MP0002086_abnormal_extraembryonic_tissu0.67825336
143MP0008007_abnormal_cellular_replicative0.67616639
144MP0001765_abnormal_ion_homeostasis0.67598876
145MP0009672_abnormal_birth_weight0.67286551
146MP0002113_abnormal_skeleton_development0.66707888
147MP0005375_adipose_tissue_phenotype0.66215710
148* MP0004197_abnormal_fetal_growth/weight/0.66019629
149MP0002115_abnormal_skeleton_extremities0.65371200
150MP0001881_abnormal_mammary_gland0.63959851
151MP0005621_abnormal_cell_physiology0.62913829
152MP0003724_increased_susceptibility_to0.62435942
153MP0005379_endocrine/exocrine_gland_phen0.60987351
154MP0002088_abnormal_embryonic_growth/wei0.58409187
155MP0010155_abnormal_intestine_physiology0.57692336
156MP0000462_abnormal_digestive_system0.57372173
157MP0009703_decreased_birth_body0.57233870
158MP0004808_abnormal_hematopoietic_stem0.57166337
159MP0001873_stomach_inflammation0.57150211
160MP0003866_abnormal_defecation0.56566462

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.21734216
2Hypoglycemic coma (HP:0001325)4.15286867
3Hypoglycemic seizures (HP:0002173)4.05941910
4Premature rupture of membranes (HP:0001788)3.99404065
5Cervical subluxation (HP:0003308)3.77203768
6Abnormality of the intrinsic pathway (HP:0010989)3.65124590
7Protrusio acetabuli (HP:0003179)3.51937261
8Hyperglycemia (HP:0003074)3.40141700
9Symptomatic seizures (HP:0011145)3.33370416
10Cerebral aneurysm (HP:0004944)3.28399654
11Urinary glycosaminoglycan excretion (HP:0003541)3.27944666
12Mucopolysacchariduria (HP:0008155)3.27944666
13Alopecia of scalp (HP:0002293)3.23351193
14Onycholysis (HP:0001806)3.22468746
15Abnormality of endocrine pancreas physiology (HP:0012093)3.16184072
16Abnormality of the pancreatic islet cells (HP:0006476)3.16184072
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.10548598
18Follicular hyperkeratosis (HP:0007502)3.09045974
19Dysostosis multiplex (HP:0000943)3.01377570
20Aortic aneurysm (HP:0004942)2.94754076
21Deep venous thrombosis (HP:0002625)2.93772958
22Ankyloglossia (HP:0010296)2.89930231
23Abnormality of mucopolysaccharide metabolism (HP:0011020)2.83421661
24Abnormality of polysaccharide metabolism (HP:0011012)2.83421661
25Abnormality of glycosaminoglycan metabolism (HP:0004371)2.83421661
26Abnormality of the common coagulation pathway (HP:0010990)2.83329293
27Thoracolumbar scoliosis (HP:0002944)2.82570541
28Aortic dissection (HP:0002647)2.80922653
29Abnormality of oral frenula (HP:0000190)2.80274593
30Right ventricular cardiomyopathy (HP:0011663)2.78782600
31Abnormal pancreas size (HP:0012094)2.76402434
32Fragile skin (HP:0001030)2.76370739
33Pancreatic islet-cell hyperplasia (HP:0004510)2.68426183
34Insulin-resistant diabetes mellitus (HP:0000831)2.64463109
35Abnormal gallbladder physiology (HP:0012438)2.60497340
36Cholecystitis (HP:0001082)2.60497340
37Aneurysm (HP:0002617)2.53249157
38Natal tooth (HP:0000695)2.51564795
39Hematochezia (HP:0002573)2.51409366
40Abnormality of carpal bone ossification (HP:0006257)2.48519870
41Pterygium (HP:0001059)2.47670994
42Atrophic scars (HP:0001075)2.47098064
43Upper limb muscle weakness (HP:0003484)2.42644834
44Tetraparesis (HP:0002273)2.41287445
45Thrombocytosis (HP:0001894)2.40314222
46Deviation of the thumb (HP:0009603)2.37372381
47Fragile nails (HP:0001808)2.37010096
48Flat acetabular roof (HP:0003180)2.36346264
49Selective tooth agenesis (HP:0001592)2.34570783
50Small epiphyses (HP:0010585)2.34332344
51Subacute progressive viral hepatitis (HP:0006572)2.31396769
52Dilatation of the ascending aorta (HP:0005111)2.30805795
53Nail dystrophy (HP:0008404)2.30245904
54Ketoacidosis (HP:0001993)2.27856497
55Vacuolated lymphocytes (HP:0001922)2.25863965
56Soft skin (HP:0000977)2.25851682
57Thin bony cortex (HP:0002753)2.25022102
58Milia (HP:0001056)2.24636618
59Hand muscle atrophy (HP:0009130)2.23813617
60Vertebral compression fractures (HP:0002953)2.23739013
61Late onset (HP:0003584)2.22804843
62Severe short stature (HP:0003510)2.20341920
63Back pain (HP:0003418)2.19797663
64Overlapping toe (HP:0001845)2.18931655
65Abnormality of nail color (HP:0100643)2.18809174
66Hyperacusis (HP:0010780)2.17228392
67Wormian bones (HP:0002645)2.17212596
68Trismus (HP:0000211)2.14406944
69Blepharitis (HP:0000498)2.14252181
70Abnormal tarsal ossification (HP:0008369)2.13428411
71Insulin resistance (HP:0000855)2.13212762
72Abnormal foot bone ossification (HP:0010675)2.12472832
73Osteolytic defects of the hand bones (HP:0009699)2.10947567
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.10947567
75Abnormality of dentin (HP:0010299)2.09608285
76Spondylolisthesis (HP:0003302)2.08742312
77Advanced eruption of teeth (HP:0006288)2.08631182
78Beaking of vertebral bodies (HP:0004568)2.08626475
79Ankle contracture (HP:0006466)2.07652028
80Long palpebral fissure (HP:0000637)2.07450832
81Abdominal distention (HP:0003270)2.06860793
82Insomnia (HP:0100785)2.06546001
83Long toe (HP:0010511)2.05458817
84Shallow orbits (HP:0000586)2.05394805
85Peritonitis (HP:0002586)2.04916162
86Abnormal delivery (HP:0001787)2.03457978
87Thick nail (HP:0001805)2.00812387
88Abnormality of the distal phalanges of the toes (HP:0010182)2.00765065
89Broad face (HP:0000283)2.00726292
90Elbow flexion contracture (HP:0002987)2.00285454
91Mitral valve prolapse (HP:0001634)1.99871527
92Plantar hyperkeratosis (HP:0007556)1.99664346
93Abnormal ossification of hand bones (HP:0005921)1.98573276
94Achilles tendon contracture (HP:0001771)1.96829658
95Blue sclerae (HP:0000592)1.93920881
96Persistence of primary teeth (HP:0006335)1.93876418
97Increased density of long bones (HP:0006392)1.92825629
98Bladder diverticulum (HP:0000015)1.92378394
99Abnormality of the umbilical cord (HP:0010881)1.90819063
100Proximal placement of thumb (HP:0009623)1.90256421
101Platyspondyly (HP:0000926)1.88842576
102Short nail (HP:0001799)1.88493459
103Generalized aminoaciduria (HP:0002909)1.88120941
104Renal duplication (HP:0000075)1.87728118
105Upper limb amyotrophy (HP:0009129)1.87693177
106Distal upper limb amyotrophy (HP:0007149)1.87693177
107Sparse eyelashes (HP:0000653)1.86976760
108Spastic diplegia (HP:0001264)1.86914661
109Protuberant abdomen (HP:0001538)1.86176595
110Abnormality of the Achilles tendon (HP:0005109)1.85404513
111Entropion (HP:0000621)1.83964280
112Missing ribs (HP:0000921)1.82492267
113Prominent metopic ridge (HP:0005487)1.82242675
114Termporal pattern (HP:0011008)1.80775396
115Insidious onset (HP:0003587)1.80775396
116Rectal prolapse (HP:0002035)1.80336868
117Hammertoe (HP:0001765)1.79204924
118Vascular tortuosity (HP:0004948)1.78586880
119Large for gestational age (HP:0001520)1.78542150
120Interstitial pulmonary disease (HP:0006530)1.77234133
121Abnormality of glycolysis (HP:0004366)1.76235880
122Arterial tortuosity (HP:0005116)1.76226438
123Joint stiffness (HP:0001387)1.75546685
124Breech presentation (HP:0001623)1.75221358
125Mildly elevated creatine phosphokinase (HP:0008180)1.74178991
126Nonimmune hydrops fetalis (HP:0001790)1.73097188
127Micronodular cirrhosis (HP:0001413)1.72897062
128Exostoses (HP:0100777)1.72337044
129Abnormality of proline metabolism (HP:0010907)1.71640124
130Hydroxyprolinuria (HP:0003080)1.71640124
131Exocrine pancreatic insufficiency (HP:0001738)1.71321601
132Abnormality of calcium-phosphate metabolism (HP:0100530)1.71076185
133Abnormal biliary tract morphology (HP:0012440)1.70356883
134Cortical dysplasia (HP:0002539)1.70171845
135Nuclear cataract (HP:0100018)1.69461600
136Coxa valga (HP:0002673)1.68215130
137Abnormality of the acetabulum (HP:0003170)1.67651284
138Pili torti (HP:0003777)1.67098150
139Abnormalities of placenta or umbilical cord (HP:0001194)1.66651217
140Joint laxity (HP:0001388)1.66500913
141Ulnar bowing (HP:0003031)1.64965150
14211 pairs of ribs (HP:0000878)1.63735449
143Ridged nail (HP:0001807)1.63628356
144Cardiovascular calcification (HP:0011915)1.62846760
145Abnormality of the calcaneus (HP:0008364)1.62448174
146Myocardial infarction (HP:0001658)1.61780223
147Orthostatic hypotension (HP:0001278)1.61001475
148Disproportionate short-trunk short stature (HP:0003521)1.60175990
149Abnormal hair laboratory examination (HP:0003328)1.60164989
150Skin nodule (HP:0200036)1.59923316
151Abnormal hand bone ossification (HP:0010660)1.59657119
152Abnormality of subcutaneous fat tissue (HP:0001001)1.58871427
153Spinal rigidity (HP:0003306)1.58666212
154Abnormality of the fetal cardiovascular system (HP:0010948)1.58432050
155Abnormal umbilical cord blood vessels (HP:0011403)1.58432050
156Single umbilical artery (HP:0001195)1.58432050
157Neonatal death (HP:0003811)1.57712603
158Coxa vara (HP:0002812)1.57514486
159Elevated alkaline phosphatase (HP:0003155)1.57198055
160Abnormality of the odontoid process (HP:0003310)1.57144612
161Epiphyseal dysplasia (HP:0002656)1.56880301
162Bowel diverticulosis (HP:0005222)1.55903212
163Retinal atrophy (HP:0001105)1.55789134
164Microglossia (HP:0000171)1.55734802
165Abnormality of the metopic suture (HP:0005556)1.55444794
166Mucosal telangiectasiae (HP:0100579)1.55011277
167Vertebral hypoplasia (HP:0008417)1.54128009
168Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.54128009
169Inguinal hernia (HP:0000023)1.53502852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.37488988
2PASK3.42399573
3FRK3.16324986
4EIF2AK12.83011539
5TAOK32.78359740
6TRIB32.68238650
7SCYL22.60153860
8LATS22.57467222
9MAPK152.38421953
10INSRR2.35339435
11PKN22.19480755
12LATS12.11825419
13PDGFRA2.02963835
14FLT32.01020029
15PTK61.97645446
16EPHA21.89977927
17ERBB41.85326092
18ICK1.83236120
19NTRK11.79684725
20EPHA31.75100822
21SIK31.73553890
22TTK1.67445207
23TTN1.58575239
24NEK11.58471068
25SMG11.53248698
26MAP3K31.50305275
27SIK11.49577946
28EIF2AK31.43542735
29TESK11.41264556
30IRAK31.35588395
31FGFR41.34650435
32ARAF1.33972902
33MAP3K21.33348159
34RPS6KA41.29086088
35EEF2K1.26158329
36TSSK61.26033561
37DDR21.23705043
38MAP3K91.23136088
39HIPK21.22995792
40BRSK21.17714367
41JAK31.15992011
42NEK91.15899215
43RIPK11.15294471
44MOS1.15089548
45PTK21.13884317
46TGFBR21.13007578
47STK101.11465531
48PAK21.10630968
49MET1.08976819
50MAP3K101.08216834
51WEE11.07123680
52TGFBR11.07046058
53SRPK11.06530239
54FER1.05251668
55MAP3K141.00646095
56JAK10.98975831
57LRRK20.96157378
58BUB10.96074877
59CDK80.95937163
60PDK20.93959671
61PBK0.93709456
62STK30.93640821
63MTOR0.92828915
64NME20.91858995
65CDK120.91644487
66PIK3CG0.91596754
67CLK10.91360200
68TBK10.90150775
69CHUK0.89985028
70PAK40.89236753
71FGFR30.88002452
72PNCK0.84885440
73AKT30.83745515
74ERBB30.79899181
75ITK0.79043103
76ZAP700.78498103
77EPHB10.78249967
78PDGFRB0.78122426
79TYK20.77779085
80PLK40.77395673
81KSR20.75901620
82MAP3K130.75842918
83BCR0.75530383
84LMTK20.73060484
85CDK70.72282082
86PRPF4B0.71240473
87TESK20.70313283
88DYRK1B0.68151007
89NUAK10.67282480
90MST40.65298394
91BMX0.64845164
92EIF2AK20.63633006
93MAP2K30.63199902
94STK38L0.63117846
95CDK90.62358943
96BCKDK0.62348341
97CDC42BPA0.62327321
98TRPM70.61998774
99MAP2K20.61434513
100MST1R0.61081241
101RAF10.60975575
102KSR10.60660398
103STK380.59874239
104JAK20.58811321
105BRSK10.58538309
106EPHB20.57385300
107GSK3A0.56275461
108PRKD30.56093515
109ROCK20.55891641
110CHEK10.55681470
111CSK0.55582836
112MAP3K80.54992782
113WNK40.54808083
114MAP3K10.54027168
115LIMK10.53634961
116MAP3K120.52982450
117CAMK1D0.52815433
118ACVR1B0.52758932
119TEC0.52182508
120MKNK10.51038377
121IRAK40.50366276
122FGFR10.50095008
123MELK0.49309447
124CDK60.47547884
125DMPK0.47526560
126TAOK20.45723216
127MAPKAPK20.45218303
128RPS6KB20.44555185
129IGF1R0.43215122
130PAK30.42722855
131IRAK10.42271064
132CAMKK20.42127693
133BRAF0.41945032
134PLK20.41939610
135RPS6KA20.41856209
136BTK0.40237609
137PIM20.39516324
138MYLK0.38836061
139RET0.38814504
140YES10.38344879
141INSR0.35639303
142MAPKAPK30.35076883
143MARK30.33431618
144PLK30.33374505
145AURKB0.33252755
146PIM10.31853682
147EGFR0.31446581
148ALK0.31289957
149BRD40.31278582

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.48469755
2* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041415.08740460
3* Protein export_Homo sapiens_hsa030604.74311095
4N-Glycan biosynthesis_Homo sapiens_hsa005102.76427639
5Sulfur metabolism_Homo sapiens_hsa009202.60268977
6Selenocompound metabolism_Homo sapiens_hsa004502.12221905
7* Antigen processing and presentation_Homo sapiens_hsa046122.05296775
8Legionellosis_Homo sapiens_hsa051341.83579369
9Biosynthesis of amino acids_Homo sapiens_hsa012301.81800885
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.79708290
11Lysosome_Homo sapiens_hsa041421.70282256
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61690330
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58898174
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58327271
15Fructose and mannose metabolism_Homo sapiens_hsa000511.53899808
16ECM-receptor interaction_Homo sapiens_hsa045121.51187041
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43742245
18Other glycan degradation_Homo sapiens_hsa005111.42404238
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42117629
20Vibrio cholerae infection_Homo sapiens_hsa051101.41928264
21Proteasome_Homo sapiens_hsa030501.41809084
22One carbon pool by folate_Homo sapiens_hsa006701.41289622
23Steroid biosynthesis_Homo sapiens_hsa001001.38677491
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36723011
25Carbon metabolism_Homo sapiens_hsa012001.30570651
26* Prion diseases_Homo sapiens_hsa050201.25750593
27Pentose phosphate pathway_Homo sapiens_hsa000301.25688525
28Focal adhesion_Homo sapiens_hsa045101.24664906
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24470630
30Type I diabetes mellitus_Homo sapiens_hsa049401.24407153
31Shigellosis_Homo sapiens_hsa051311.24240813
32Small cell lung cancer_Homo sapiens_hsa052221.21033940
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17178696
34Spliceosome_Homo sapiens_hsa030401.16655074
35Protein digestion and absorption_Homo sapiens_hsa049741.13403280
36Cell cycle_Homo sapiens_hsa041101.12949862
37Bladder cancer_Homo sapiens_hsa052191.12248780
38Insulin resistance_Homo sapiens_hsa049311.11038959
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10230777
40Prostate cancer_Homo sapiens_hsa052151.07146960
41* Thyroid hormone synthesis_Homo sapiens_hsa049181.01425878
42Toxoplasmosis_Homo sapiens_hsa051450.99619139
43Adherens junction_Homo sapiens_hsa045200.99449930
44Amoebiasis_Homo sapiens_hsa051460.99409573
45Leishmaniasis_Homo sapiens_hsa051400.99295474
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.99168214
47mRNA surveillance pathway_Homo sapiens_hsa030150.98935482
48Renin-angiotensin system_Homo sapiens_hsa046140.97213705
49Proteoglycans in cancer_Homo sapiens_hsa052050.96549772
50Viral carcinogenesis_Homo sapiens_hsa052030.96127925
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95157551
52DNA replication_Homo sapiens_hsa030300.94308161
53Type II diabetes mellitus_Homo sapiens_hsa049300.93963092
54Sphingolipid metabolism_Homo sapiens_hsa006000.92604078
55Galactose metabolism_Homo sapiens_hsa000520.92416039
56Fatty acid elongation_Homo sapiens_hsa000620.92330005
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91579428
58Phagosome_Homo sapiens_hsa041450.88446378
59Chronic myeloid leukemia_Homo sapiens_hsa052200.87137294
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86975046
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85356416
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.84925838
63Apoptosis_Homo sapiens_hsa042100.84067164
64TNF signaling pathway_Homo sapiens_hsa046680.83979062
65Pyruvate metabolism_Homo sapiens_hsa006200.82106277
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79482851
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.77954079
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76310916
69Osteoclast differentiation_Homo sapiens_hsa043800.75948141
70Prolactin signaling pathway_Homo sapiens_hsa049170.75776657
71Salmonella infection_Homo sapiens_hsa051320.75347430
72Starch and sucrose metabolism_Homo sapiens_hsa005000.74328876
73Nucleotide excision repair_Homo sapiens_hsa034200.74191660
74Complement and coagulation cascades_Homo sapiens_hsa046100.74016514
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.71803445
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71656308
77Renal cell carcinoma_Homo sapiens_hsa052110.71560437
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68737548
79TGF-beta signaling pathway_Homo sapiens_hsa043500.67069676
80MicroRNAs in cancer_Homo sapiens_hsa052060.66883051
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66000132
82Fat digestion and absorption_Homo sapiens_hsa049750.65765904
83Tryptophan metabolism_Homo sapiens_hsa003800.64518862
84HIF-1 signaling pathway_Homo sapiens_hsa040660.64232528
85HTLV-I infection_Homo sapiens_hsa051660.63846195
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63338778
87Thyroid cancer_Homo sapiens_hsa052160.63014318
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62993339
89Arginine and proline metabolism_Homo sapiens_hsa003300.62456056
90Hepatitis B_Homo sapiens_hsa051610.62324712
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62304199
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62163832
93Lysine degradation_Homo sapiens_hsa003100.61979562
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60169340
95Pertussis_Homo sapiens_hsa051330.59145284
96Pancreatic cancer_Homo sapiens_hsa052120.58190091
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57866600
98mTOR signaling pathway_Homo sapiens_hsa041500.57531734
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56823598
100p53 signaling pathway_Homo sapiens_hsa041150.56026020
101Pathways in cancer_Homo sapiens_hsa052000.55488158
102Malaria_Homo sapiens_hsa051440.55079370
103Influenza A_Homo sapiens_hsa051640.53982194
104Measles_Homo sapiens_hsa051620.53943454
105Folate biosynthesis_Homo sapiens_hsa007900.53237173
106Insulin secretion_Homo sapiens_hsa049110.52911485
107Glutathione metabolism_Homo sapiens_hsa004800.52017570
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51378255
109Mismatch repair_Homo sapiens_hsa034300.49960505
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.49148432
111Staphylococcus aureus infection_Homo sapiens_hsa051500.48526571
112Estrogen signaling pathway_Homo sapiens_hsa049150.48353766
113Glucagon signaling pathway_Homo sapiens_hsa049220.47691948
114Arginine biosynthesis_Homo sapiens_hsa002200.47535695
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46491252
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45671898
117Fatty acid metabolism_Homo sapiens_hsa012120.45546733
118Systemic lupus erythematosus_Homo sapiens_hsa053220.44100708
119ABC transporters_Homo sapiens_hsa020100.43399278
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43381395
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.42601305
122Vitamin B6 metabolism_Homo sapiens_hsa007500.42375577
123Circadian rhythm_Homo sapiens_hsa047100.42120985
124Non-homologous end-joining_Homo sapiens_hsa034500.40757111
125Epstein-Barr virus infection_Homo sapiens_hsa051690.40129986
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39265130
127Hepatitis C_Homo sapiens_hsa051600.39220372
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38914076
129Herpes simplex infection_Homo sapiens_hsa051680.38342172
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37712106
131RNA transport_Homo sapiens_hsa030130.36029933
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35789272
133Hippo signaling pathway_Homo sapiens_hsa043900.35209973
134Endometrial cancer_Homo sapiens_hsa052130.33123184
135FoxO signaling pathway_Homo sapiens_hsa040680.33051205
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.32923309
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32082835
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32021796
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.31231441
140Viral myocarditis_Homo sapiens_hsa054160.30430396
141Fatty acid degradation_Homo sapiens_hsa000710.30039688
142Tuberculosis_Homo sapiens_hsa051520.28765439
143AMPK signaling pathway_Homo sapiens_hsa041520.27674594
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27666920
145Acute myeloid leukemia_Homo sapiens_hsa052210.27508708
146Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26898877

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