HSPA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.61397121
2negative regulation of cell killing (GO:0031342)5.61397121
3positive regulation of gamma-delta T cell activation (GO:0046645)5.51391262
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.39514001
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.39514001
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.39514001
7modulation by symbiont of host immune response (GO:0052553)5.39514001
8positive regulation by symbiont of host defense response (GO:0052509)5.39514001
9modulation by symbiont of host defense response (GO:0052031)5.39514001
10neutrophil activation involved in immune response (GO:0002283)5.13814692
11response to peptidoglycan (GO:0032494)5.12989870
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.05879688
13macrophage activation involved in immune response (GO:0002281)5.02539597
14negative regulation of interleukin-12 production (GO:0032695)4.92551986
15detection of other organism (GO:0098543)4.79630787
16detection of bacterium (GO:0016045)4.63052757
17antigen processing and presentation of endogenous antigen (GO:0019883)4.61737470
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.51980358
19immunoglobulin mediated immune response (GO:0016064)4.32323402
20detection of molecule of bacterial origin (GO:0032490)4.22267939
21detection of external biotic stimulus (GO:0098581)4.19155615
22regulation of gamma-delta T cell activation (GO:0046643)4.16785657
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.09885706
24cellular extravasation (GO:0045123)4.00989378
25regulation of mast cell degranulation (GO:0043304)3.98822912
26microglial cell activation (GO:0001774)3.98201418
27regulation of interferon-beta biosynthetic process (GO:0045357)3.96914271
28macrophage activation (GO:0042116)3.85395631
29negative regulation of erythrocyte differentiation (GO:0045647)3.78475056
30regulation of B cell receptor signaling pathway (GO:0050855)3.75377751
31response to muramyl dipeptide (GO:0032495)3.73372459
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.72732282
33detection of biotic stimulus (GO:0009595)3.72415642
34neutrophil activation (GO:0042119)3.71536384
35leukocyte aggregation (GO:0070486)3.69128866
36regulation of mast cell activation involved in immune response (GO:0033006)3.65605366
37response to host immune response (GO:0052572)3.61214788
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.61214788
39positive regulation of mast cell activation (GO:0033005)3.61152338
40granulocyte activation (GO:0036230)3.60851350
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.59841246
42regulation of myeloid leukocyte mediated immunity (GO:0002886)3.59756570
43respiratory burst (GO:0045730)3.57948140
44germinal center formation (GO:0002467)3.54905219
45myeloid cell activation involved in immune response (GO:0002275)3.53306386
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.49873078
47positive regulation of cellular amide metabolic process (GO:0034250)3.48962709
48cellular response to type I interferon (GO:0071357)3.48245843
49type I interferon signaling pathway (GO:0060337)3.48245843
50response to type I interferon (GO:0034340)3.48151819
51regulation of leukocyte degranulation (GO:0043300)3.44894188
52interferon-gamma-mediated signaling pathway (GO:0060333)3.43690484
53regulation of mast cell activation (GO:0033003)3.41999196
54negative regulation of cytokine production involved in immune response (GO:0002719)3.39038970
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.37371809
56regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.36717884
57negative regulation of leukocyte mediated immunity (GO:0002704)3.36199329
58positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.35610373
59negative regulation of T cell mediated immunity (GO:0002710)3.34594293
60positive regulation of mast cell activation involved in immune response (GO:0033008)3.34564624
61positive regulation of mast cell degranulation (GO:0043306)3.34564624
62defense response to protozoan (GO:0042832)3.34464715
63regulation of T-helper 2 cell differentiation (GO:0045628)3.33878205
64response to host (GO:0075136)3.32816247
65response to host defenses (GO:0052200)3.32816247
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32816247
67leukocyte migration involved in inflammatory response (GO:0002523)3.31250748
68regulation of T cell tolerance induction (GO:0002664)3.25399739
69B cell mediated immunity (GO:0019724)3.24902888
70regulation of gamma-delta T cell differentiation (GO:0045586)3.23192037
71regulation of antigen processing and presentation (GO:0002577)3.21608830
72positive regulation of antigen processing and presentation (GO:0002579)3.14309751
73response to protozoan (GO:0001562)3.08737520
74regulation of tolerance induction (GO:0002643)3.08401385
75T-helper 1 type immune response (GO:0042088)3.05376308
76NIK/NF-kappaB signaling (GO:0038061)2.99020157
77positive regulation of interferon-alpha production (GO:0032727)2.98700646
78regulation of interferon-alpha production (GO:0032647)2.98260862
79production of molecular mediator involved in inflammatory response (GO:0002532)2.97395293
80negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.97277923
81positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.96748025
82positive regulation of type 2 immune response (GO:0002830)2.96664845
83positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96440593
84negative regulation of innate immune response (GO:0045824)2.94920355
85antigen processing and presentation via MHC class Ib (GO:0002475)2.92145304
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85167777
87regulation of regulated secretory pathway (GO:1903305)2.84967911
88B cell receptor signaling pathway (GO:0050853)2.81338310
89positive thymic T cell selection (GO:0045059)2.81309233
90positive regulation of B cell differentiation (GO:0045579)2.79441082
91myeloid leukocyte activation (GO:0002274)2.78681713
92regulation of type 2 immune response (GO:0002828)2.78568598
93negative regulation of alpha-beta T cell activation (GO:0046636)2.78156603
94negative regulation of interleukin-6 production (GO:0032715)2.77431997
95positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.76813452
96neutrophil mediated immunity (GO:0002446)2.75842780
97negative regulation of production of molecular mediator of immune response (GO:0002701)2.71682217
98T cell migration (GO:0072678)2.71391899
99negative regulation of type 2 immune response (GO:0002829)2.70610836
100leukocyte degranulation (GO:0043299)2.69904498

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.35463331
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.61949378
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.17611445
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.27844765
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.26052473
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.23481959
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.12764996
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.85103417
9VDR_21846776_ChIP-Seq_THP-1_Human2.83621332
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77803437
11VDR_24763502_ChIP-Seq_THP-1_Human2.66996459
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58842146
13SPI1_23127762_ChIP-Seq_K562_Human2.48574167
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43689005
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38314189
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34448424
17SPI1_23547873_ChIP-Seq_NB4_Human2.29353540
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28908951
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25571755
20KDM2B_26808549_Chip-Seq_SUP-B15_Human2.25529509
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.21682120
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18792327
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18131882
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18011682
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16807671
26RUNX_20019798_ChIP-Seq_JUKART_Human2.12721251
27MAF_26560356_Chip-Seq_TH1_Human2.12613029
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07588364
29STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06118659
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.02908775
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02750095
32MYC_22102868_ChIP-Seq_BL_Human2.01357614
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.97466258
34SCL_19346495_ChIP-Seq_HPC-7_Human1.97250106
35TCF7_22412390_ChIP-Seq_EML_Mouse1.89671480
36KDM2B_26808549_Chip-Seq_DND41_Human1.84887635
37UTX_26944678_Chip-Seq_JUKART_Human1.82573782
38VDR_24787735_ChIP-Seq_THP-1_Human1.81980563
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80737236
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80512073
41LXR_22292898_ChIP-Seq_THP-1_Human1.80372519
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74066752
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73889310
44* MYB_26560356_Chip-Seq_TH2_Human1.73249587
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.72964777
46MAF_26560356_Chip-Seq_TH2_Human1.64842072
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57151498
48MYB_26560356_Chip-Seq_TH1_Human1.50717642
49* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47075344
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.46578416
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46178839
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44773085
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39519596
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35586558
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35366719
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34103274
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32956826
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30930966
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30735284
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29284149
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27784520
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.27452074
63PU_27001747_Chip-Seq_BMDM_Mouse1.26785991
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25933915
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24931194
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24805944
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22988527
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22745918
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22508808
70GATA1_19941826_ChIP-Seq_K562_Human1.21580330
71GATA3_27048872_Chip-Seq_THYMUS_Human1.21199908
72BCL6_27268052_Chip-Seq_Bcells_Human1.19165014
73* KDM2B_26808549_Chip-Seq_JURKAT_Human1.18929173
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18536198
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18462188
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17928909
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15252917
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14472003
79BCOR_27268052_Chip-Seq_Bcells_Human1.13301245
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12146803
81GATA1_22025678_ChIP-Seq_K562_Human1.09928155
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07918231
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03133988
84RACK7_27058665_Chip-Seq_MCF-7_Human1.02862742
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00470288
86RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99737104
87SA1_27219007_Chip-Seq_ERYTHROID_Human0.99529958
88KDM2B_26808549_Chip-Seq_K562_Human0.99127732
89GATA2_21666600_ChIP-Seq_HMVEC_Human0.98889307
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94815607
91NCOR1_26117541_ChIP-Seq_K562_Human0.94491952
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.93250676
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92427297
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91282376
95* GATA3_26560356_Chip-Seq_TH2_Human0.89886052
96STAT1_20625510_ChIP-Seq_HELA_Human0.89490581
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88850777
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84376797
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83917780
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.83745565

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.31801467
2MP0003436_decreased_susceptibility_to4.11932152
3MP0003303_peritoneal_inflammation4.09298856
4MP0001835_abnormal_antigen_presentation3.56407193
5MP0006082_CNS_inflammation3.15904719
6MP0002419_abnormal_innate_immunity3.14536183
7MP0005387_immune_system_phenotype2.97683812
8MP0001790_abnormal_immune_system2.97683812
9MP0005671_abnormal_response_to2.92681003
10MP0009785_altered_susceptibility_to2.92039216
11MP0005025_abnormal_response_to2.82586078
12MP0005058_abnormal_lysosome_morphology2.81631772
13MP0005000_abnormal_immune_tolerance2.80202457
14MP0001800_abnormal_humoral_immune2.68224908
15MP0000685_abnormal_immune_system2.65044698
16MP0002148_abnormal_hypersensitivity_rea2.62736659
17MP0002723_abnormal_immune_serum2.49072023
18MP0003300_gastrointestinal_ulcer2.47873054
19MP0002452_abnormal_antigen_presenting2.47828444
20MP0003172_abnormal_lysosome_physiology2.46150771
21MP0002420_abnormal_adaptive_immunity2.30319177
22MP0001819_abnormal_immune_cell2.28761609
23MP0001533_abnormal_skeleton_physiology2.21327941
24MP0003191_abnormal_cellular_cholesterol1.96857297
25MP0003828_pulmonary_edema1.94978876
26MP0009278_abnormal_bone_marrow1.94253851
27MP0002405_respiratory_system_inflammati1.93711140
28MP0004510_myositis1.89132850
29MP0008260_abnormal_autophagy1.82962959
30MP0001845_abnormal_inflammatory_respons1.76152878
31MP0004947_skin_inflammation1.74943086
32MP0005464_abnormal_platelet_physiology1.74278531
33MP0000343_altered_response_to1.72461122
34MP0003075_altered_response_to1.71241269
35MP0010155_abnormal_intestine_physiology1.70766324
36MP0000716_abnormal_immune_system1.67363097
37MP0009764_decreased_sensitivity_to1.66141617
38MP0002998_abnormal_bone_remodeling1.55649055
39MP0008469_abnormal_protein_level1.55264921
40MP0002398_abnormal_bone_marrow1.54025955
41MP0003690_abnormal_glial_cell1.51864539
42MP0009840_abnormal_foam_cell1.49233877
43MP0009333_abnormal_splenocyte_physiolog1.45969961
44MP0003763_abnormal_thymus_physiology1.43482024
45MP0005310_abnormal_salivary_gland1.41887654
46MP0002132_abnormal_respiratory_system1.39452998
47MP0003806_abnormal_nucleotide_metabolis1.39057857
48MP0003183_abnormal_peptide_metabolism1.38757200
49MP0005451_abnormal_body_composition1.36439124
50MP0000858_altered_metastatic_potential1.34603347
51MP0000689_abnormal_spleen_morphology1.31807738
52MP0001545_abnormal_hematopoietic_system1.31698913
53MP0005397_hematopoietic_system_phenotyp1.31698913
54MP0001853_heart_inflammation1.29688140
55MP0002429_abnormal_blood_cell1.28734188
56MP0004883_abnormal_blood_vessel1.27011035
57MP0002722_abnormal_immune_system1.25235454
58MP0001851_eye_inflammation1.24374797
59MP0000465_gastrointestinal_hemorrhage1.21772469
60MP0008004_abnormal_stomach_pH1.18159264
61MP0000604_amyloidosis1.17986993
62MP0005166_decreased_susceptibility_to1.15861209
63MP0002933_joint_inflammation1.13620864
64MP0002277_abnormal_respiratory_mucosa1.10164144
65MP0003866_abnormal_defecation1.09126690
66MP0003448_altered_tumor_morphology1.08521193
67MP0005164_abnormal_response_to1.07513060
68MP0005390_skeleton_phenotype1.05602416
69MP0003453_abnormal_keratinocyte_physiol0.94547542
70MP0000703_abnormal_thymus_morphology0.94324633
71MP0005167_abnormal_blood-brain_barrier0.92575508
72MP0004381_abnormal_hair_follicle0.89855582
73MP0001663_abnormal_digestive_system0.87756992
74MP0009763_increased_sensitivity_to0.87442052
75MP0001873_stomach_inflammation0.86588694
76MP0000249_abnormal_blood_vessel0.79061213
77MP0003795_abnormal_bone_structure0.78777293
78MP0002396_abnormal_hematopoietic_system0.76158310
79MP0002254_reproductive_system_inflammat0.74965983
80MP0003656_abnormal_erythrocyte_physiolo0.74749796
81MP0003091_abnormal_cell_migration0.74365238
82MP0002332_abnormal_exercise_endurance0.74244507
83MP0000920_abnormal_myelination0.68337754
84MP0002138_abnormal_hepatobiliary_system0.68233003
85MP0001986_abnormal_taste_sensitivity0.67062954
86MP0008874_decreased_physiological_sensi0.66005359
87MP0001958_emphysema0.64777649
88MP0009765_abnormal_xenobiotic_induced0.63534445
89MP0003279_aneurysm0.59111663
90MP0003221_abnormal_cardiomyocyte_apopto0.57117463
91MP0005076_abnormal_cell_differentiation0.56937234
92MP0006054_spinal_hemorrhage0.56682317
93MP0003705_abnormal_hypodermis_morpholog0.54462967
94MP0004808_abnormal_hematopoietic_stem0.54155025
95MP0000767_abnormal_smooth_muscle0.54095141
96MP0002166_altered_tumor_susceptibility0.54086098
97MP0003045_fibrosis0.51721137
98MP0001542_abnormal_bone_strength0.51293842
99MP0005319_abnormal_enzyme/_coenzyme0.50893633
100MP0003329_amyloid_beta_deposits0.50882627

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.93985154
2Recurrent bacterial skin infections (HP:0005406)5.61657327
3Recurrent abscess formation (HP:0002722)5.61319653
4Abnormality of macrophages (HP:0004311)5.60672947
5Myositis (HP:0100614)5.25857889
6Orchitis (HP:0100796)5.04740343
7Retrobulbar optic neuritis (HP:0100654)4.79558221
8Optic neuritis (HP:0100653)4.79558221
9Recurrent gram-negative bacterial infections (HP:0005420)4.63080643
10Abnormality of glycolipid metabolism (HP:0010969)4.30785526
11Abnormality of liposaccharide metabolism (HP:0010968)4.30785526
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.30785526
13Stomatitis (HP:0010280)4.14484359
14Mediastinal lymphadenopathy (HP:0100721)4.04064534
15Elevated erythrocyte sedimentation rate (HP:0003565)3.87432986
16Recurrent skin infections (HP:0001581)3.71740025
17Recurrent fungal infections (HP:0002841)3.66633174
18Systemic lupus erythematosus (HP:0002725)3.64791320
19Spontaneous hematomas (HP:0007420)3.63969036
20Obstructive lung disease (HP:0006536)3.62283865
21Chronic obstructive pulmonary disease (HP:0006510)3.62283865
22Meningitis (HP:0001287)3.55365163
23Increased cerebral lipofuscin (HP:0011813)3.52458151
24Keratoconjunctivitis sicca (HP:0001097)3.43685833
25Gastrointestinal infarctions (HP:0005244)3.36028415
26Dysostosis multiplex (HP:0000943)3.30596229
27Chronic mucocutaneous candidiasis (HP:0002728)3.24155014
28Recurrent cutaneous fungal infections (HP:0011370)3.24155014
29Vasculitis (HP:0002633)3.23261367
30Increased IgE level (HP:0003212)3.21225821
31Gingivitis (HP:0000230)3.20939105
32Encephalitis (HP:0002383)3.18661185
33Abnormal delayed hypersensitivity skin test (HP:0002963)3.18542938
34Keratoconjunctivitis (HP:0001096)3.13340246
35Loss of speech (HP:0002371)3.06806757
36Hemoptysis (HP:0002105)3.03001256
37Pulmonary infiltrates (HP:0002113)2.98905290
38Colitis (HP:0002583)2.91596271
39Amyloidosis (HP:0011034)2.89540134
40Vacuolated lymphocytes (HP:0001922)2.89292940
41Urticaria (HP:0001025)2.89180400
42Inflammation of the large intestine (HP:0002037)2.86035856
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.81455471
44Gastrointestinal inflammation (HP:0004386)2.75812632
45Prolonged bleeding time (HP:0003010)2.75325063
46Cellulitis (HP:0100658)2.74786234
47Recurrent viral infections (HP:0004429)2.69006561
48Purpura (HP:0000979)2.63360699
49Glomerulonephritis (HP:0000099)2.58116204
50Increased serum ferritin (HP:0003281)2.57458128
51Axonal loss (HP:0003447)2.55182188
52Pustule (HP:0200039)2.49309392
53Episodic fever (HP:0001954)2.48607584
54Chest pain (HP:0100749)2.47193351
55Disinhibition (HP:0000734)2.46041042
56Petechiae (HP:0000967)2.44253908
57Pulmonary embolism (HP:0002204)2.43007104
58Hematochezia (HP:0002573)2.42586150
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40846607
60Abnormality of polysaccharide metabolism (HP:0011012)2.40846607
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40846607
62Epistaxis (HP:0000421)2.40621217
63Malnutrition (HP:0004395)2.36064796
64Arterial thrombosis (HP:0004420)2.35712573
65Leukocytosis (HP:0001974)2.31000790
66Anorexia (HP:0002039)2.29825515
67Hepatosplenomegaly (HP:0001433)2.29061731
68Nuclear cataract (HP:0100018)2.28974488
69Panhypogammaglobulinemia (HP:0003139)2.28702686
70Abnormality of the pleura (HP:0002103)2.26520227
71Mucopolysacchariduria (HP:0008155)2.25926203
72Urinary glycosaminoglycan excretion (HP:0003541)2.25926203
73Abnormality of iron homeostasis (HP:0011031)2.24953107
74Peritonitis (HP:0002586)2.24717627
75Gastrointestinal stroma tumor (HP:0100723)2.24088296
76Osteomyelitis (HP:0002754)2.23601200
77T lymphocytopenia (HP:0005403)2.21586573
78Mutism (HP:0002300)2.20916061
79Gingival bleeding (HP:0000225)2.19481114
80Gangrene (HP:0100758)2.18219183
81Hypochromic anemia (HP:0001931)2.16678769
82Increased IgM level (HP:0003496)2.14929138
83Autoimmune thrombocytopenia (HP:0001973)2.13199441
84Abnormality of T cell number (HP:0011839)2.09561689
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.05830455
86Abnormality of the endocardium (HP:0004306)2.03098302
87Lymphopenia (HP:0001888)2.02630387
88Neuronal loss in central nervous system (HP:0002529)2.01931502
89Hypergammaglobulinemia (HP:0010702)2.01777718
90Premature loss of primary teeth (HP:0006323)2.01103728
91Restrictive lung disease (HP:0002091)2.00709322
92Interstitial pulmonary disease (HP:0006530)2.00142049
93Acne (HP:0001061)1.99787687
94Vertigo (HP:0002321)1.98221197
95Polyneuropathy (HP:0001271)1.98083527
96Abnormality of the peritoneum (HP:0002585)1.96653472
97Hypochromic microcytic anemia (HP:0004840)1.95350301
98Abnormality of T cells (HP:0002843)1.93470447
99Glomerulopathy (HP:0100820)1.92480526
100Sepsis (HP:0100806)1.91108683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.76459846
2RIPK44.64157427
3MAP4K13.22866068
4TYK22.93924126
5ERN12.91413319
6IRAK42.74292214
7CSK2.55510287
8MAP2K32.49947635
9PRPF4B2.32600341
10TNK22.28864358
11FES2.14437618
12MAP3K141.95036097
13ZAP701.93440260
14TBK11.89675058
15FGR1.89675033
16MAP3K131.83159304
17MAPK151.81134432
18MAP3K31.78744735
19JAK31.70712079
20TAOK11.66413397
21IKBKE1.60574616
22SYK1.57323277
23MAP3K111.57070799
24EPHB11.55437790
25BTK1.51342050
26HCK1.45503083
27CSF1R1.39520801
28TGFBR21.36934401
29GRK61.36133655
30LYN1.36082905
31JAK11.34946595
32TRIB31.31981431
33TXK1.30505246
34MAP3K11.23897492
35IKBKB1.21078537
36JAK21.18714540
37GRK71.17649432
38MATK1.17605475
39SIK31.15781926
40CDC42BPA1.15225282
41KIT1.13378936
42IRAK31.13034379
43TAOK21.07909872
44KSR21.07657331
45LCK1.05983444
46MAP3K61.03817804
47TAOK31.01998930
48MARK20.99536826
49BMPR20.93209738
50PRKD20.92800304
51IRAK20.91272682
52IRAK10.89616856
53MARK30.89149124
54YES10.87967500
55SIK10.86292983
56PDPK10.81612243
57ITK0.79187276
58SIK20.77922496
59PDK10.77187397
60PTK60.74177432
61MAPK70.73454714
62MAP3K70.71937767
63STK100.69225475
64MAPK120.66508706
65TEC0.63982242
66MAP2K60.63106661
67MOS0.62364933
68FYN0.59675993
69RPS6KL10.58584792
70RPS6KC10.58584792
71DYRK1B0.56438098
72BMX0.56011524
73RIPK10.55875192
74MAP3K20.54113025
75HIPK20.50782464
76FGFR40.50233111
77MAP3K50.50175137
78RPS6KA60.50094046
79RET0.44995878
80RPS6KA20.39883479
81CHUK0.39289908
82PRKD10.38207577
83PDGFRB0.38086648
84LRRK20.37709377
85DAPK20.36664502
86FGFR30.36305883
87MAPKAPK20.36173707
88EPHA30.35581012
89PTK2B0.34103594
90CDK190.33751787
91TESK20.33648632
92PIM10.33283089
93PRKCQ0.32973941
94MAPK40.31993286
95STK110.31121245
96ABL10.29648471
97TYRO30.29050249
98KSR10.28993024
99NME20.27540776
100DDR20.27313485

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.30280973
2Leishmaniasis_Homo sapiens_hsa051403.02858203
3Osteoclast differentiation_Homo sapiens_hsa043802.99753423
4Other glycan degradation_Homo sapiens_hsa005112.52006358
5Allograft rejection_Homo sapiens_hsa053302.50581841
6Graft-versus-host disease_Homo sapiens_hsa053322.43189407
7Autoimmune thyroid disease_Homo sapiens_hsa053202.25607021
8Tuberculosis_Homo sapiens_hsa051522.20164462
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18749761
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02997704
11B cell receptor signaling pathway_Homo sapiens_hsa046622.00689910
12Antigen processing and presentation_Homo sapiens_hsa046121.97278570
13Malaria_Homo sapiens_hsa051441.94772567
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90717481
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87274814
16Asthma_Homo sapiens_hsa053101.83922421
17Type I diabetes mellitus_Homo sapiens_hsa049401.81919620
18Legionellosis_Homo sapiens_hsa051341.80369603
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78725904
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.76262699
21Toxoplasmosis_Homo sapiens_hsa051451.74293125
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.68938378
23Rheumatoid arthritis_Homo sapiens_hsa053231.68050199
24Influenza A_Homo sapiens_hsa051641.65187824
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64204683
26Lysosome_Homo sapiens_hsa041421.61883273
27Phagosome_Homo sapiens_hsa041451.56534545
28Pertussis_Homo sapiens_hsa051331.56296875
29Hematopoietic cell lineage_Homo sapiens_hsa046401.55647807
30Primary immunodeficiency_Homo sapiens_hsa053401.54270514
31Measles_Homo sapiens_hsa051621.52836794
32TNF signaling pathway_Homo sapiens_hsa046681.51646649
33Viral myocarditis_Homo sapiens_hsa054161.49840890
34Chemokine signaling pathway_Homo sapiens_hsa040621.42857456
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42640344
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38868855
37Acute myeloid leukemia_Homo sapiens_hsa052211.36247951
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34829536
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.33322835
40T cell receptor signaling pathway_Homo sapiens_hsa046601.27301369
41Herpes simplex infection_Homo sapiens_hsa051681.23594870
42African trypanosomiasis_Homo sapiens_hsa051431.19994648
43Salmonella infection_Homo sapiens_hsa051321.16546289
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14100502
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.10966356
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00203808
47Hepatitis B_Homo sapiens_hsa051610.99476994
48Hepatitis C_Homo sapiens_hsa051600.97156062
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93171575
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.92800779
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91870072
52Notch signaling pathway_Homo sapiens_hsa043300.89509549
53VEGF signaling pathway_Homo sapiens_hsa043700.89371107
54Platelet activation_Homo sapiens_hsa046110.88425051
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86717277
56Shigellosis_Homo sapiens_hsa051310.83890296
57Apoptosis_Homo sapiens_hsa042100.82611882
58Amoebiasis_Homo sapiens_hsa051460.75271579
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74879946
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74551593
61Epstein-Barr virus infection_Homo sapiens_hsa051690.72642575
62Prion diseases_Homo sapiens_hsa050200.71783587
63Non-small cell lung cancer_Homo sapiens_hsa052230.68358414
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.67653588
65Pancreatic cancer_Homo sapiens_hsa052120.65629076
66Chronic myeloid leukemia_Homo sapiens_hsa052200.65533912
67Endocytosis_Homo sapiens_hsa041440.65399251
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.64909460
69Prolactin signaling pathway_Homo sapiens_hsa049170.64010864
70GnRH signaling pathway_Homo sapiens_hsa049120.63956071
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.62596727
72Renal cell carcinoma_Homo sapiens_hsa052110.62403672
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.59643021
74Complement and coagulation cascades_Homo sapiens_hsa046100.57800130
75Estrogen signaling pathway_Homo sapiens_hsa049150.56704126
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54984722
77Collecting duct acid secretion_Homo sapiens_hsa049660.50365220
78Choline metabolism in cancer_Homo sapiens_hsa052310.49947727
79HTLV-I infection_Homo sapiens_hsa051660.48072310
80MAPK signaling pathway_Homo sapiens_hsa040100.47313215
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45749976
82Type II diabetes mellitus_Homo sapiens_hsa049300.45272876
83HIF-1 signaling pathway_Homo sapiens_hsa040660.44921219
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43826957
85Bladder cancer_Homo sapiens_hsa052190.43659106
86Dorso-ventral axis formation_Homo sapiens_hsa043200.40214535
87FoxO signaling pathway_Homo sapiens_hsa040680.39606477
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39521221
89mTOR signaling pathway_Homo sapiens_hsa041500.39309252
90Viral carcinogenesis_Homo sapiens_hsa052030.38727054
91Insulin resistance_Homo sapiens_hsa049310.38078673
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36336262
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34803855
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.32165256
95Rap1 signaling pathway_Homo sapiens_hsa040150.30828476
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29212952
97ErbB signaling pathway_Homo sapiens_hsa040120.29069748
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27264575
99Endometrial cancer_Homo sapiens_hsa052130.25932732
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25843633

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