ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nucleobase biosynthetic process (GO:0046112)	5.62122670
2	purine nucleobase biosynthetic process (GO:0009113)	5.37912696
3	establishment of integrated proviral latency (GO:0075713)	5.34475450
4	DNA unwinding involved in DNA replication (GO:0006268)	4.77316366
5	IMP biosynthetic process (GO:0006188)	4.77167908
6	mitotic sister chromatid cohesion (GO:0007064)	4.46003697
7	mitotic chromosome condensation (GO:0007076)	4.33425315
8	DNA replication initiation (GO:0006270)	4.32885385
9	cullin deneddylation (GO:0010388)	4.21694107
10	mitotic sister chromatid segregation (GO:0000070)	4.15563999
11	establishment of viral latency (GO:0019043)	4.10804102
12	double-strand break repair via nonhomologous end joining (GO:0006303)	4.07041006
13	non-recombinational repair (GO:0000726)	4.07041006
14	DNA strand elongation involved in DNA replication (GO:0006271)	4.06851552
15	regulation of translational termination (GO:0006449)	4.06333323
16	protein complex localization (GO:0031503)	4.03573363
17	ribosome biogenesis (GO:0042254)	4.03091639
18	nuclear pore organization (GO:0006999)	3.95608027
19	regulation of translational fidelity (GO:0006450)	3.94280151
20	IMP metabolic process (GO:0046040)	3.94120297
21	peptidyl-arginine omega-N-methylation (GO:0035247)	3.93941355
22	ribosome assembly (GO:0042255)	3.93377720
23	formation of translation preinitiation complex (GO:0001731)	3.89302629
24	DNA strand elongation (GO:0022616)	3.88646622
25	protein deneddylation (GO:0000338)	3.84367996
26	sister chromatid segregation (GO:0000819)	3.83681426
27	DNA replication checkpoint (GO:0000076)	3.81620335
28	mitotic nuclear envelope disassembly (GO:0007077)	3.75201713
29	protein localization to kinetochore (GO:0034501)	3.72385917
30	cellular protein complex localization (GO:0034629)	3.70638502
31	NADH metabolic process (GO:0006734)	3.66599166
32	postreplication repair (GO:0006301)	3.66404917
33	regulation of mitotic spindle organization (GO:0060236)	3.61042545
34	peptidyl-arginine N-methylation (GO:0035246)	3.57219993
35	peptidyl-arginine methylation (GO:0018216)	3.57219993
36	mitotic metaphase plate congression (GO:0007080)	3.54777372
37	nuclear pore complex assembly (GO:0051292)	3.51792338
38	telomere maintenance via semi-conservative replication (GO:0032201)	3.51093197
39	nuclear envelope disassembly (GO:0051081)	3.51007294
40	membrane disassembly (GO:0030397)	3.51007294
41	positive regulation of chromosome segregation (GO:0051984)	3.49080403
42	histone arginine methylation (GO:0034969)	3.46675751
43	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.46584692
44	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.42429121
45	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.40737984
46	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.36632494
47	tRNA aminoacylation for protein translation (GO:0006418)	3.35385079
48	DNA replication-dependent nucleosome organization (GO:0034723)	3.33521668
49	DNA replication-dependent nucleosome assembly (GO:0006335)	3.33521668
50	DNA ligation (GO:0006266)	3.31488969
51	maturation of 5.8S rRNA (GO:0000460)	3.30148688
52	amino acid activation (GO:0043038)	3.29758812
53	tRNA aminoacylation (GO:0043039)	3.29758812
54	histone H2A acetylation (GO:0043968)	3.27859513
55	folic acid-containing compound biosynthetic process (GO:0009396)	3.25175362
56	regulation of sister chromatid cohesion (GO:0007063)	3.24789590
57	DNA double-strand break processing (GO:0000729)	3.23339195
58	nuclear envelope organization (GO:0006998)	3.22262061
59	Golgi transport vesicle coating (GO:0048200)	3.21851381
60	COPI coating of Golgi vesicle (GO:0048205)	3.21851381
61	spliceosomal snRNP assembly (GO:0000387)	3.20926889
62	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.18898832
63	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.18898832
64	DNA topological change (GO:0006265)	3.18427724
65	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.16303248
66	regulation of centrosome cycle (GO:0046605)	3.12806460
67	regulation of spindle organization (GO:0090224)	3.12786444
68	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.12656561
69	RNA-dependent DNA replication (GO:0006278)	3.11971453
70	G1/S transition of mitotic cell cycle (GO:0000082)	3.10953755
71	cell cycle G1/S phase transition (GO:0044843)	3.10953755
72	telomere maintenance via recombination (GO:0000722)	3.10077755
73	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.09670881
74	regulation of mitotic sister chromatid separation (GO:0010965)	3.09015366
75	regulation of mitotic sister chromatid segregation (GO:0033047)	3.09015366
76	regulation of sister chromatid segregation (GO:0033045)	3.09015366
77	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.07670140
78	negative regulation of ligase activity (GO:0051352)	3.07670140
79	mitotic recombination (GO:0006312)	3.07573552
80	metaphase plate congression (GO:0051310)	3.07541609
81	DNA duplex unwinding (GO:0032508)	3.06268728
82	DNA geometric change (GO:0032392)	3.05650400
83	regulation of centrosome duplication (GO:0010824)	3.01676702
84	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.01491515
85	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.98439545
86	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.98439545
87	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.98081819
88	DNA replication-independent nucleosome organization (GO:0034724)	2.98043228
89	DNA replication-independent nucleosome assembly (GO:0006336)	2.98043228
90	telomere maintenance via telomere lengthening (GO:0010833)	2.97267683
91	de novo protein folding (GO:0006458)	2.96156353
92	establishment of chromosome localization (GO:0051303)	2.95248907
93	protein localization to chromosome (GO:0034502)	2.94788216
94	proteasome assembly (GO:0043248)	2.94179235
95	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.93492823
96	protein export from nucleus (GO:0006611)	2.93160912
97	CENP-A containing nucleosome assembly (GO:0034080)	2.92044106
98	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.90898413
99	negative regulation of sister chromatid segregation (GO:0033046)	2.90898413
100	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.90898413
101	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.90898413
102	mitotic spindle assembly checkpoint (GO:0007094)	2.90688294
103	chromosome segregation (GO:0007059)	2.90488305
104	histone exchange (GO:0043486)	2.89241662
105	negative regulation of chromosome segregation (GO:0051985)	2.89236927
106	7-methylguanosine mRNA capping (GO:0006370)	2.88923691
107	rRNA processing (GO:0006364)	2.87894722
108	oxaloacetate metabolic process (GO:0006107)	2.87377949
109	spindle assembly checkpoint (GO:0071173)	2.86132456
110	chromatin remodeling at centromere (GO:0031055)	2.84672229
111	DNA conformation change (GO:0071103)	2.84633233
112	ribonucleoprotein complex biogenesis (GO:0022613)	2.83736730
113	RNA capping (GO:0036260)	2.82251437
114	7-methylguanosine RNA capping (GO:0009452)	2.82251437
115	regulation of chromosome segregation (GO:0051983)	2.82153975
116	DNA damage response, detection of DNA damage (GO:0042769)	2.82101888
117	mRNA splicing, via spliceosome (GO:0000398)	2.80620771
118	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)	2.80620771
119	regulation of centriole replication (GO:0046599)	2.80567480
120	viral mRNA export from host cell nucleus (GO:0046784)	2.80542040
121	RNA splicing, via transesterification reactions (GO:0000375)	2.80084713
122	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.79742210
123	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.79683402
124	pore complex assembly (GO:0046931)	2.79497666
125	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.79282815
126	protein localization to chromosome, centromeric region (GO:0071459)	2.78606389
127	mitotic spindle checkpoint (GO:0071174)	2.78085649
128	rRNA metabolic process (GO:0016072)	2.78044679
129	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.78024497
130	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.78024497
131	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.77866068
132	positive regulation of ligase activity (GO:0051351)	2.77806109
133	spindle checkpoint (GO:0031577)	2.77758058

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.57719041
2	* MYC_18555785_ChIP-Seq_MESCs_Mouse	4.13477178
3	* E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.87884261
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.63874037
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.59971000
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.42133012
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.38286408
8	* MYC_19079543_ChIP-ChIP_MESCs_Mouse	3.15800273
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.10243660
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.06376402
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.06368741
12	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.90427472
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.89347826
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.85945139
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.83641161
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.77333367
17	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.64180266
18	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.59559494
19	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.46573865
20	* NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.43961519
21	VDR_23849224_ChIP-Seq_CD4+_Human	2.43552614
22	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.41356777
23	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.38005025
24	XRN2_22483619_ChIP-Seq_HELA_Human	2.30099555
25	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.17196708
26	FOXP3_21729870_ChIP-Seq_TREG_Human	2.16986257
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.16064564
28	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.14626855
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12028240
30	AR_21909140_ChIP-Seq_LNCAP_Human	2.11490812
31	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.07182479
32	GABP_19822575_ChIP-Seq_HepG2_Human	2.00021796
33	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.98454129
34	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.95416996
35	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.89970920
36	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.87889286
37	DCP1A_22483619_ChIP-Seq_HELA_Human	1.87663697
38	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.86682822
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.85812870
40	CIITA_25753668_ChIP-Seq_RAJI_Human	1.84354461
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.83538801
42	* TTF2_22483619_ChIP-Seq_HELA_Human	1.81787977
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.79656998
44	* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.79231514
45	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78549444
46	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.69364198
47	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.66034108
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.64759888
49	KDM5A_27292631_Chip-Seq_BREAST_Human	1.64488662
50	* PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.57647106
51	* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.56313031
52	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.54214932
53	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.51534603
54	* MYC_22102868_ChIP-Seq_BL_Human	1.49619403
55	* CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.48066420
56	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.46965905
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.44198369
58	* ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.43922743
59	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.40665695
60	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.35016943
61	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.26527671
62	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.26321193
63	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.24089462
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.23366838
65	ZNF263_19887448_ChIP-Seq_K562_Human	1.20834649
66	* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.18039300
67	* ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.17119272
68	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.17041743
69	* TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.15195109
70	* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.13440800
71	CLOCK_20551151_ChIP-Seq_293T_Human	1.13020843
72	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.11814547
73	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.11438262
74	* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.10177018
75	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.09065690
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.06910907
77	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.06879623
78	CHD1_26751641_Chip-Seq_LNCaP_Human	1.05174520
79	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.05015305
80	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04027402
81	* SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.01711149
82	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.99127606
83	TFEB_21752829_ChIP-Seq_HELA_Human	0.97305513
84	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.96535912
85	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.93912609
86	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.91989195
87	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.91126279
88	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.90639180
89	* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.90566396
90	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.90262022
91	* EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.89852355
92	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.89826550
93	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.89328833
94	* ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.88563182
95	* KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.88454565
96	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.88063780
97	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.86653098
98	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.86510961
99	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.85981616
100	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.85922740
101	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.85448139
102	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.81456130
103	* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.80310920
104	* STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.79418727
105	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.79417499
106	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.79074659
107	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.77816960
108	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.77275937
109	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.76556880
110	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.76036492
111	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.75586177
112	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.75558595
113	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.73618232
114	EWS_26573619_Chip-Seq_HEK293_Human	0.73275145

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	4.53150323
2	MP0003693_abnormal_embryo_hatching	4.26820171
3	MP0003111_abnormal_nucleus_morphology	3.95049766
4	MP0004957_abnormal_blastocyst_morpholog	3.91068626
5	MP0008057_abnormal_DNA_replication	3.89790091
6	MP0008877_abnormal_DNA_methylation	3.89277260
7	MP0003123_paternal_imprinting	3.68704288
8	MP0003077_abnormal_cell_cycle	3.51199851
9	MP0008058_abnormal_DNA_repair	3.24366609
10	MP0008007_abnormal_cellular_replicative	2.78172955
11	MP0010234_abnormal_vibrissa_follicle	2.70744330
12	MP0003121_genomic_imprinting	2.57355534
13	MP0003941_abnormal_skin_development	2.52034564
14	MP0003787_abnormal_imprinting	2.45718563
15	MP0008932_abnormal_embryonic_tissue	2.40743988
16	MP0002396_abnormal_hematopoietic_system	2.32478069
17	MP0003122_maternal_imprinting	2.31772307
18	MP0001730_embryonic_growth_arrest	2.14897209
19	MP0000350_abnormal_cell_proliferation	2.07196037
20	MP0003786_premature_aging	1.94939659
21	MP0002877_abnormal_melanocyte_morpholog	1.94484319
22	MP0010307_abnormal_tumor_latency	1.91007056
23	MP0001529_abnormal_vocalization	1.71162310
24	MP0009046_muscle_twitch	1.66902467
25	MP0002736_abnormal_nociception_after	1.65904391
26	MP0010352_gastrointestinal_tract_polyps	1.61895434
27	MP0003880_abnormal_central_pattern	1.61005506
28	MP0005380_embryogenesis_phenotype	1.53238435
29	MP0001672_abnormal_embryogenesis/_devel	1.53238435
30	MP0001697_abnormal_embryo_size	1.51662565
31	MP0003984_embryonic_growth_retardation	1.49190142
32	MP0000579_abnormal_nail_morphology	1.46164628
33	MP0002088_abnormal_embryonic_growth/wei	1.43316395
34	MP0002080_prenatal_lethality	1.42098684
35	MP0008260_abnormal_autophagy	1.40839026
36	MP0002796_impaired_skin_barrier	1.39160222
37	MP0004808_abnormal_hematopoietic_stem	1.37775065
38	MP0001968_abnormal_touch/_nociception	1.35756316
39	MP0004859_abnormal_synaptic_plasticity	1.34658928
40	MP0002064_seizures	1.27673476
41	MP0003566_abnormal_cell_adhesion	1.26874819
42	MP0001346_abnormal_lacrimal_gland	1.24990004
43	MP0003937_abnormal_limbs/digits/tail_de	1.22776746
44	MP0009745_abnormal_behavioral_response	1.21878832
45	MP0002653_abnormal_ependyma_morphology	1.20962440
46	MP0005646_abnormal_pituitary_gland	1.19073372
47	MP0003635_abnormal_synaptic_transmissio	1.18919973
48	MP0000313_abnormal_cell_death	1.16443632
49	MP0009333_abnormal_splenocyte_physiolog	1.14708006
50	MP0003718_maternal_effect	1.14577118
51	MP0005623_abnormal_meninges_morphology	1.14015423
52	MP0004233_abnormal_muscle_weight	1.13871673
53	MP0002085_abnormal_embryonic_tissue	1.12789976
54	MP0005501_abnormal_skin_physiology	1.12628074
55	MP0003705_abnormal_hypodermis_morpholog	1.09364110
56	MP0002084_abnormal_developmental_patter	1.09245611
57	MP0009697_abnormal_copulation	1.08058375
58	MP0002697_abnormal_eye_size	1.07971855
59	MP0002063_abnormal_learning/memory/cond	1.07356802
60	MP0004185_abnormal_adipocyte_glucose	1.07038975
61	MP0002735_abnormal_chemical_nociception	1.05626436
62	MP0002086_abnormal_extraembryonic_tissu	1.05611894
63	MP0004197_abnormal_fetal_growth/weight/	1.04745196
64	MP0000703_abnormal_thymus_morphology	1.03729838
65	MP0003890_abnormal_embryonic-extraembry	1.03083730
66	MP0002019_abnormal_tumor_incidence	1.03060218
67	MP0000537_abnormal_urethra_morphology	1.02062165
68	MP0003950_abnormal_plasma_membrane	1.01593341
69	MP0002160_abnormal_reproductive_system	1.00151989
70	MP0001661_extended_life_span	0.99675736
71	MP0001188_hyperpigmentation	0.98518217
72	MP0002009_preneoplasia	0.97833428
73	MP0003763_abnormal_thymus_physiology	0.96399347
74	MP0000627_abnormal_mammary_gland	0.95681184
75	MP0001348_abnormal_lacrimal_gland	0.95650664
76	MP0002572_abnormal_emotion/affect_behav	0.94173160
77	MP0001293_anophthalmia	0.93504962
78	MP0002822_catalepsy	0.88545227
79	MP0005384_cellular_phenotype	0.88308006
80	MP0001501_abnormal_sleep_pattern	0.86983094
81	MP0000490_abnormal_crypts_of	0.86942517
82	MP0000358_abnormal_cell_content/	0.85160244
83	MP0002210_abnormal_sex_determination	0.84948642
84	MP0000762_abnormal_tongue_morphology	0.84801956
85	MP0002272_abnormal_nervous_system	0.84610465
86	MP0004147_increased_porphyrin_level	0.84061352
87	MP0002111_abnormal_tail_morphology	0.84056245
88	MP0010678_abnormal_skin_adnexa	0.83870512
89	MP0001177_atelectasis	0.83496117
90	MP0004782_abnormal_surfactant_physiolog	0.82789622
91	MP0005397_hematopoietic_system_phenotyp	0.81546153
92	MP0001545_abnormal_hematopoietic_system	0.81546153
93	MP0002398_abnormal_bone_marrow	0.81294798
94	MP0003183_abnormal_peptide_metabolism	0.81069920
95	MP0001286_abnormal_eye_development	0.80750595
96	MP0003567_abnormal_fetal_cardiomyocyte	0.80587327
97	MP0001727_abnormal_embryo_implantation	0.80113409
98	MP0005621_abnormal_cell_physiology	0.79743565
99	MP0000647_abnormal_sebaceous_gland	0.79613366
100	MP0006035_abnormal_mitochondrial_morpho	0.79452198
101	MP0001216_abnormal_epidermal_layer	0.79243023
102	MP0000428_abnormal_craniofacial_morphol	0.78266418
103	MP0001881_abnormal_mammary_gland	0.77908328
104	MP0004811_abnormal_neuron_physiology	0.77490097
105	MP0009672_abnormal_birth_weight	0.77343258
106	MP0006054_spinal_hemorrhage	0.76703478
107	MP0003861_abnormal_nervous_system	0.75946208
108	MP0004084_abnormal_cardiac_muscle	0.75694765
109	MP0001145_abnormal_male_reproductive	0.75357313
110	MP0002067_abnormal_sensory_capabilities	0.74610603
111	MP0002734_abnormal_mechanical_nocicepti	0.74234970
112	MP0002722_abnormal_immune_system	0.73809586
113	MP0001849_ear_inflammation	0.73660230
114	MP0003866_abnormal_defecation	0.73366608
115	MP0003879_abnormal_hair_cell	0.72282283
116	MP0005499_abnormal_olfactory_system	0.72248455
117	MP0005394_taste/olfaction_phenotype	0.72248455
118	MP0002060_abnormal_skin_morphology	0.72222349
119	MP0001299_abnormal_eye_distance/	0.72093366
120	MP0002092_abnormal_eye_morphology	0.70949171
121	MP0003119_abnormal_digestive_system	0.70880835
122	MP0000377_abnormal_hair_follicle	0.70306773
123	MP0005076_abnormal_cell_differentiation	0.69268846
124	MP0001986_abnormal_taste_sensitivity	0.69006037
125	MP0005389_reproductive_system_phenotype	0.68892731
126	MP0002098_abnormal_vibrissa_morphology	0.68640853
127	MP0009703_decreased_birth_body	0.66795571
128	MP0002876_abnormal_thyroid_physiology	0.66732982
129	MP0003943_abnormal_hepatobiliary_system	0.66508682
130	MP0001915_intracranial_hemorrhage	0.65921372
131	MP0004272_abnormal_basement_membrane	0.65835332
132	MP0005187_abnormal_penis_morphology	0.65407019
133	MP0002751_abnormal_autonomic_nervous	0.65090563
134	MP0000427_abnormal_hair_cycle	0.64828809
135	MP0008872_abnormal_physiological_respon	0.64707511
136	MP0001929_abnormal_gametogenesis	0.64316127
137	MP0005386_behavior/neurological_phenoty	0.63390675
138	MP0004924_abnormal_behavior	0.63390675
139	MP0000689_abnormal_spleen_morphology	0.62738779
140	MP0003755_abnormal_palate_morphology	0.61885598
141	MP0002233_abnormal_nose_morphology	0.61827513
142	MP0000653_abnormal_sex_gland	0.61179939
143	MP0003385_abnormal_body_wall	0.61158843
144	MP0002081_perinatal_lethality	0.59987887
145	MP0006072_abnormal_retinal_apoptosis	0.58556572
146	MP0003221_abnormal_cardiomyocyte_apopto	0.58013117
147	MP0003315_abnormal_perineum_morphology	0.57331045
148	MP0002269_muscular_atrophy	0.56460832
149	MP0004264_abnormal_extraembryonic_tissu	0.55818158

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	5.28474928
2	Birth length less than 3rd percentile (HP:0003561)	4.99881248
3	Cerebral hypomyelination (HP:0006808)	4.13975646
4	Cortical dysplasia (HP:0002539)	3.89509926
5	Agnosia (HP:0010524)	3.51724360
6	Shoulder girdle muscle weakness (HP:0003547)	3.35378784
7	Increased nuchal translucency (HP:0010880)	3.16040831
8	Insidious onset (HP:0003587)	3.11014447
9	Termporal pattern (HP:0011008)	3.11014447
10	Abnormal hair whorl (HP:0010721)	3.10467934
11	Degeneration of anterior horn cells (HP:0002398)	3.04325576
12	Abnormality of the anterior horn cell (HP:0006802)	3.04325576
13	Focal motor seizures (HP:0011153)	2.99946245
14	Abnormality of glycolysis (HP:0004366)	2.99061928
15	Increased serum pyruvate (HP:0003542)	2.99061928
16	Atonic seizures (HP:0010819)	2.95923664
17	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.92107789
18	Breast hypoplasia (HP:0003187)	2.88575686
19	Medulloblastoma (HP:0002885)	2.86969394
20	Ependymoma (HP:0002888)	2.85822826
21	Microvesicular hepatic steatosis (HP:0001414)	2.83058615
22	Nephroblastoma (Wilms tumor) (HP:0002667)	2.72630069
23	Epileptic encephalopathy (HP:0200134)	2.70406467
24	Pelvic girdle muscle weakness (HP:0003749)	2.67026920
25	Multiple enchondromatosis (HP:0005701)	2.65421380
26	Embryonal renal neoplasm (HP:0011794)	2.61252355
27	Oral leukoplakia (HP:0002745)	2.56033575
28	CNS hypomyelination (HP:0003429)	2.55582169
29	Spastic diplegia (HP:0001264)	2.53009718
30	Tongue fasciculations (HP:0001308)	2.48735346
31	Patellar aplasia (HP:0006443)	2.48603283
32	Abnormality of alanine metabolism (HP:0010916)	2.48383713
33	Hyperalaninemia (HP:0003348)	2.48383713
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.48383713
35	Deviation of the thumb (HP:0009603)	2.48378158
36	Postnatal microcephaly (HP:0005484)	2.43994765
37	Proximal placement of thumb (HP:0009623)	2.42861664
38	Rough bone trabeculation (HP:0100670)	2.39659758
39	Chromsome breakage (HP:0040012)	2.39646354
40	Aplasia/Hypoplasia of the patella (HP:0006498)	2.38195594
41	Abnormal lung lobation (HP:0002101)	2.37392619
42	Resting tremor (HP:0002322)	2.37331453
43	Deep philtrum (HP:0002002)	2.32764545
44	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.31714419
45	Abnormality of chromosome stability (HP:0003220)	2.29114758
46	Abnormality of the hip-girdle musculature (HP:0001445)	2.29013984
47	Abnormality of the musculature of the pelvis (HP:0001469)	2.29013984
48	Absent epiphyses (HP:0010577)	2.26504676
49	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.26504676
50	Abnormality of the preputium (HP:0100587)	2.24097372
51	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.22357760
52	Irregular epiphyses (HP:0010582)	2.19629151
53	Selective tooth agenesis (HP:0001592)	2.18630921
54	Unsteady gait (HP:0002317)	2.16886394
55	Myelodysplasia (HP:0002863)	2.14027042
56	Progressive external ophthalmoplegia (HP:0000590)	2.14001835
57	Muscle fibrillation (HP:0010546)	2.13182124
58	Febrile seizures (HP:0002373)	2.11480946
59	Aplastic anemia (HP:0001915)	2.09870591
60	Neuroblastoma (HP:0003006)	2.08257618
61	Primitive neuroectodermal tumor (HP:0030065)	2.08257618
62	Neuroblastic tumors (HP:0004376)	2.08257618
63	Peripheral primitive neuroectodermal neoplasm (HP:0030067)	2.08257618
64	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.07357857
65	Abnormality of the umbilical cord (HP:0010881)	2.07263534
66	Missing ribs (HP:0000921)	2.06612221
67	Urinary urgency (HP:0000012)	2.06605054
68	Colon cancer (HP:0003003)	2.05374285
69	Dysmetric saccades (HP:0000641)	2.04286474
70	Abnormality of the carotid arteries (HP:0005344)	2.02977820
71	Glioma (HP:0009733)	2.02394148
72	Impulsivity (HP:0100710)	2.01897445
73	Meckel diverticulum (HP:0002245)	2.00925524
74	Small intestinal stenosis (HP:0012848)	2.00668314
75	Duodenal stenosis (HP:0100867)	2.00668314
76	Abnormality of the astrocytes (HP:0100707)	2.00306356
77	Astrocytoma (HP:0009592)	2.00306356
78	Premature graying of hair (HP:0002216)	2.00239743
79	Abnormality of the ileum (HP:0001549)	1.98470796
80	Microglossia (HP:0000171)	1.98061491
81	Rhabdomyosarcoma (HP:0002859)	1.96838671
82	Overlapping toe (HP:0001845)	1.95574811
83	Carpal bone hypoplasia (HP:0001498)	1.95161168
84	Failure to thrive in infancy (HP:0001531)	1.95020112
85	Abnormality of the lower motor neuron (HP:0002366)	1.94880016
86	Poor suck (HP:0002033)	1.93297016
87	Abnormality of pain sensation (HP:0010832)	1.93026738
88	Impaired pain sensation (HP:0007328)	1.93026738
89	Abnormality of the duodenum (HP:0002246)	1.92503885
90	Abnormal gallbladder physiology (HP:0012438)	1.92265199
91	Cholecystitis (HP:0001082)	1.92265199
92	Bone marrow hypocellularity (HP:0005528)	1.92017799
93	Insomnia (HP:0100785)	1.90876412
94	Choanal atresia (HP:0000453)	1.89154787
95	Sloping forehead (HP:0000340)	1.89098869
96	Amaurosis fugax (HP:0100576)	1.88972778
97	Abnormality of oral frenula (HP:0000190)	1.88754233
98	Abnormal number of incisors (HP:0011064)	1.87927158
99	Ankyloglossia (HP:0010296)	1.87697298
100	Delayed puberty (HP:0000823)	1.87639564
101	Cellular immunodeficiency (HP:0005374)	1.86351179
102	Volvulus (HP:0002580)	1.86165986
103	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.85520430
104	Impaired smooth pursuit (HP:0007772)	1.85344516
105	Freckling (HP:0001480)	1.84785041
106	Absent radius (HP:0003974)	1.84656031
107	Impaired vibration sensation in the lower limbs (HP:0002166)	1.84333634
108	Secondary amenorrhea (HP:0000869)	1.84175407
109	Neoplasm of the pancreas (HP:0002894)	1.82596145
110	Large hands (HP:0001176)	1.82370581
111	Emotional lability (HP:0000712)	1.82197084
112	Gastrointestinal carcinoma (HP:0002672)	1.81869424
113	Malignant gastrointestinal tract tumors (HP:0006749)	1.81869424
114	Abnormality of methionine metabolism (HP:0010901)	1.81761083
115	Abnormalities of placenta or umbilical cord (HP:0001194)	1.80072244
116	Limb-girdle muscle atrophy (HP:0003797)	1.79465780
117	Hypoplasia of the pons (HP:0012110)	1.78892423
118	Absence seizures (HP:0002121)	1.78476329
119	Glossoptosis (HP:0000162)	1.78193583
120	Asymmetry of the thorax (HP:0001555)	1.77114927
121	Upper limb muscle weakness (HP:0003484)	1.76854335
122	Progressive muscle weakness (HP:0003323)	1.76358234
123	Sparse lateral eyebrow (HP:0005338)	1.76037321
124	Aplasia involving forearm bones (HP:0009822)	1.75947648
125	Absent forearm bone (HP:0003953)	1.75947648
126	Hyperventilation (HP:0002883)	1.74577036
127	Autoamputation (HP:0001218)	1.73772835
128	Protruding tongue (HP:0010808)	1.73237723
129	Uterine neoplasm (HP:0010784)	1.73236010
130	Cafe-au-lait spot (HP:0000957)	1.72695821
131	Long foot (HP:0001833)	1.72446496
132	Short nail (HP:0001799)	1.72319481
133	Aplasia/hypoplasia of the humerus (HP:0006507)	1.72224755
134	Increased serum lactate (HP:0002151)	1.71988296
135	Neoplasm of the colon (HP:0100273)	1.71823285
136	Breast carcinoma (HP:0003002)	1.70658096
137	Basal cell carcinoma (HP:0002671)	1.70504336
138	Papillary thyroid carcinoma (HP:0002895)	1.67888619
139	Horseshoe kidney (HP:0000085)	1.67279696
140	Prominent metopic ridge (HP:0005487)	1.66751139
141	Breast aplasia (HP:0100783)	1.66122601
142	Abnormal trabecular bone morphology (HP:0100671)	1.64514850
143	Neoplasm of the rectum (HP:0100743)	1.64446426
144	Spinal muscular atrophy (HP:0007269)	1.64283254
145	Lymphoma (HP:0002665)	1.63857332
146	IgM deficiency (HP:0002850)	1.63804121
147	Uterine leiomyosarcoma (HP:0002891)	1.62779155
148	Leiomyosarcoma (HP:0100243)	1.62779155
149	Premature ovarian failure (HP:0008209)	1.62765645
150	Acute myeloid leukemia (HP:0004808)	1.61986158
151	Generalized hypotonia (HP:0001290)	1.61806383
152	Abnormality of the fetal cardiovascular system (HP:0010948)	1.61756168
153	Abnormal umbilical cord blood vessels (HP:0011403)	1.61756168
154	Single umbilical artery (HP:0001195)	1.61756168
155	Hyperacusis (HP:0010780)	1.59188026
156	Nervous tissue neoplasm (HP:0030060)	1.59053165
157	Neuroepithelial neoplasm (HP:0030063)	1.59053165

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	4.80384578
2	* TSSK6	4.33556070
3	WEE1	3.53489530
4	CCNB1	3.34540615
5	CDC7	3.29265276
6	EIF2AK1	3.21497007
7	PBK	3.19104553
8	CASK	3.01218705
9	NEK1	2.90618462
10	AKT3	2.84074814
11	PLK3	2.37739231
12	SRPK1	2.09552176
13	MAP3K12	2.03097579
14	MKNK1	1.98033430
15	PNCK	1.92304920
16	MKNK2	1.88663717
17	TRIM28	1.83494674
18	CDK19	1.80920106
19	PDK4	1.80274844
20	PDK3	1.80274844
21	DAPK1	1.78900588
22	TAF1	1.72024927
23	STK16	1.71543437
24	PASK	1.69693806
25	BRSK2	1.63650346
26	EIF2AK3	1.55116750
27	SMG1	1.50535022
28	PLK2	1.48651900
29	BRSK1	1.47225172
30	PLK1	1.43616670
31	TTK	1.42606496
32	NEK2	1.41820203
33	ATR	1.40180974
34	PLK4	1.39482305
35	SIK3	1.36275349
36	PDK2	1.31816503
37	ERBB4	1.26874738
38	CDK8	1.26261374
39	VRK1	1.25809034
40	LATS2	1.22624519
41	EEF2K	1.22337582
42	EPHA2	1.19098272
43	NME1	1.16259141
44	MAP3K4	1.13140402
45	TGFBR1	1.11569596
46	ACVR1B	1.11167519
47	RPS6KB2	1.07394185
48	ALK	1.06901339
49	MST1R	1.06441217
50	MAP2K7	1.04595913
51	SCYL2	1.03388936
52	PRPF4B	0.99198774
53	CHEK1	0.99111057
54	BRAF	0.98485848
55	CDK6	0.95570605
56	MAP3K9	0.93256818
57	AURKB	0.90379781
58	AURKA	0.83666470
59	VRK2	0.83126730
60	ERBB3	0.82993163
61	PAK4	0.82228050
62	TXK	0.81749169
63	CHEK2	0.74394513
64	RPS6KA4	0.73013231
65	MINK1	0.72255890
66	TESK2	0.71893431
67	NTRK3	0.70318711
68	CLK1	0.69855642
69	MET	0.69101953
70	NEK6	0.67641023
71	CDK2	0.66362376
72	NME2	0.64979010
73	PRKCG	0.64013972
74	CDK7	0.63763367
75	CDK4	0.63456568
76	ATM	0.62361610
77	CSNK2A2	0.61568299
78	ZAK	0.61553730
79	FGFR1	0.59757539
80	TAOK2	0.59373246
81	LATS1	0.58589328
82	ICK	0.57704614
83	CDK18	0.57347782
84	MAP3K8	0.57018301
85	CDK1	0.56854570
86	PAK2	0.55790536
87	STK4	0.55482771
88	TLK1	0.54098148
89	MAP4K1	0.53395075
90	RPS6KB1	0.52015299
91	MAP3K10	0.51811198
92	TESK1	0.49609849
93	BRD4	0.48873484
94	CDK15	0.46825891
95	CSNK2A1	0.46545182
96	PDGFRA	0.45565857
97	CDK12	0.45007242
98	CDK14	0.43528755
99	CSNK1G1	0.43504350
100	CSNK1E	0.43265411
101	SGK2	0.42709092
102	CDK11A	0.39694175
103	PRKCI	0.39647161
104	BCR	0.39338677
105	PAK1	0.38836682
106	KSR1	0.37538168
107	MAPKAPK5	0.37239501
108	CSNK1A1L	0.37233920
109	MST4	0.36658579
110	STK3	0.36475551
111	PIM2	0.36293726
112	STK38L	0.35520203
113	RAF1	0.31526621
114	TTN	0.31349486
115	LIMK1	0.30877897
116	PRKDC	0.30426364
117	OXSR1	0.27866363
118	PIM1	0.26381483
119	EIF2AK2	0.25699665
120	CAMKK2	0.20231450
121	STK10	0.19233327
122	MAPK14	0.18064588
123	GSK3B	0.16096718
124	WNK3	0.15871756
125	MELK	0.15670296
126	SGK3	0.15393293
127	AKT2	0.15335863
128	PRKCB	0.14376675
129	MAP2K4	0.13949036
130	CSNK1G3	0.12625528
131	MAPK9	0.12619398

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.90861715
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.86694195
3	Proteasome_Homo sapiens_hsa03050	3.61468305
4	Mismatch repair_Homo sapiens_hsa03430	3.44514208
5	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.15502876
6	RNA transport_Homo sapiens_hsa03013	3.15192908
7	* Spliceosome_Homo sapiens_hsa03040	2.85447140
8	RNA polymerase_Homo sapiens_hsa03020	2.79955796
9	Cell cycle_Homo sapiens_hsa04110	2.48858282
10	Base excision repair_Homo sapiens_hsa03410	2.46895176
11	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.41564243
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.38048373
13	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.03756888
14	Homologous recombination_Homo sapiens_hsa03440	2.03239519
15	Collecting duct acid secretion_Homo sapiens_hsa04966	1.94207193
16	One carbon pool by folate_Homo sapiens_hsa00670	1.89885618
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.88777571
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.78917005
19	Steroid biosynthesis_Homo sapiens_hsa00100	1.71628898
20	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.69034670
21	mRNA surveillance pathway_Homo sapiens_hsa03015	1.66021011
22	RNA degradation_Homo sapiens_hsa03018	1.61159445
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.58321369
24	Nicotine addiction_Homo sapiens_hsa05033	1.51145137
25	Protein export_Homo sapiens_hsa03060	1.46250014
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.44354298
27	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.42546983
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.42531746
29	Basal transcription factors_Homo sapiens_hsa03022	1.38335375
30	Oocyte meiosis_Homo sapiens_hsa04114	1.35496472
31	* Epstein-Barr virus infection_Homo sapiens_hsa05169	1.32020985
32	Vibrio cholerae infection_Homo sapiens_hsa05110	1.31509807
33	Purine metabolism_Homo sapiens_hsa00230	1.27186464
34	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.24971059
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.18661812
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.16975092
37	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.15018144
38	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.00956524
39	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.94453071
40	p53 signaling pathway_Homo sapiens_hsa04115	0.92599463
41	Viral carcinogenesis_Homo sapiens_hsa05203	0.92398689
42	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.89863345
43	Fatty acid elongation_Homo sapiens_hsa00062	0.89796301
44	Ribosome_Homo sapiens_hsa03010	0.86695050
45	Propanoate metabolism_Homo sapiens_hsa00640	0.86295457
46	Carbon metabolism_Homo sapiens_hsa01200	0.84683305
47	Adherens junction_Homo sapiens_hsa04520	0.81347180
48	* Antigen processing and presentation_Homo sapiens_hsa04612	0.78352561
49	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.77178849
50	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.76140158
51	Pentose phosphate pathway_Homo sapiens_hsa00030	0.73813354
52	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.70234744
53	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.69516373
54	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.68644877
55	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.63458478
56	HTLV-I infection_Homo sapiens_hsa05166	0.62409557
57	Alcoholism_Homo sapiens_hsa05034	0.59642540
58	Rheumatoid arthritis_Homo sapiens_hsa05323	0.59442303
59	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.58770872
60	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.57950524
61	Amphetamine addiction_Homo sapiens_hsa05031	0.57879858
62	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.56721156
63	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.56618425
64	Colorectal cancer_Homo sapiens_hsa05210	0.56172720
65	Pyruvate metabolism_Homo sapiens_hsa00620	0.55995561
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55030543
67	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.54028992
68	Long-term potentiation_Homo sapiens_hsa04720	0.52922109
69	Folate biosynthesis_Homo sapiens_hsa00790	0.52683519
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51224255
71	* Legionellosis_Homo sapiens_hsa05134	0.50923568
72	Small cell lung cancer_Homo sapiens_hsa05222	0.49410820
73	Tight junction_Homo sapiens_hsa04530	0.49178558
74	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48429766
75	Phagosome_Homo sapiens_hsa04145	0.48262620
76	Morphine addiction_Homo sapiens_hsa05032	0.47469188
77	Olfactory transduction_Homo sapiens_hsa04740	0.47252457
78	Regulation of autophagy_Homo sapiens_hsa04140	0.47143800
79	GABAergic synapse_Homo sapiens_hsa04727	0.46160432
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.45621586
81	Lysine degradation_Homo sapiens_hsa00310	0.44369413
82	Herpes simplex infection_Homo sapiens_hsa05168	0.44150753
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43889521
84	Prostate cancer_Homo sapiens_hsa05215	0.42198186
85	Oxidative phosphorylation_Homo sapiens_hsa00190	0.41947932
86	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.40998818
87	Dopaminergic synapse_Homo sapiens_hsa04728	0.39921416
88	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.38157227
89	Huntingtons disease_Homo sapiens_hsa05016	0.36701242
90	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.34427023
91	Thyroid cancer_Homo sapiens_hsa05216	0.34159682
92	Bladder cancer_Homo sapiens_hsa05219	0.33304307
93	Arginine biosynthesis_Homo sapiens_hsa00220	0.32804049
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.32722755
95	mTOR signaling pathway_Homo sapiens_hsa04150	0.32509007
96	Endometrial cancer_Homo sapiens_hsa05213	0.32483399
97	Proteoglycans in cancer_Homo sapiens_hsa05205	0.32433125
98	Primary immunodeficiency_Homo sapiens_hsa05340	0.31652262
99	Pancreatic cancer_Homo sapiens_hsa05212	0.31573875
100	Parkinsons disease_Homo sapiens_hsa05012	0.31509059
101	Glutathione metabolism_Homo sapiens_hsa00480	0.29842235
102	Hepatitis B_Homo sapiens_hsa05161	0.29625144
103	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.29564026
104	Sulfur relay system_Homo sapiens_hsa04122	0.26656528
105	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.26211713
106	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.25659381
107	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.25013457
108	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.23477428
109	Circadian entrainment_Homo sapiens_hsa04713	0.23002533
110	* Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.22978577
111	Sulfur metabolism_Homo sapiens_hsa00920	0.22434113
112	Shigellosis_Homo sapiens_hsa05131	0.21769620
113	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.21626751
114	Glioma_Homo sapiens_hsa05214	0.21548821
115	Renin-angiotensin system_Homo sapiens_hsa04614	0.21355657
116	Metabolic pathways_Homo sapiens_hsa01100	0.20927640
117	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.20491344
118	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.20307254
119	Melanoma_Homo sapiens_hsa05218	0.20177833
120	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.19077310
121	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.19049083
122	Long-term depression_Homo sapiens_hsa04730	0.19048331
123	Gap junction_Homo sapiens_hsa04540	0.19042372
124	Taste transduction_Homo sapiens_hsa04742	0.19028984
125	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.18354451
126	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.17628334
127	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.17318451
128	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.16869624
129	* Measles_Homo sapiens_hsa05162	0.16814712
130	* Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.16679815
131	MicroRNAs in cancer_Homo sapiens_hsa05206	0.16287464
132	FoxO signaling pathway_Homo sapiens_hsa04068	0.16203480
133	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.15652724
134	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.15329477
135	ErbB signaling pathway_Homo sapiens_hsa04012	0.15193471
136	Hippo signaling pathway_Homo sapiens_hsa04390	0.14910962
137	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.14671176
138	Apoptosis_Homo sapiens_hsa04210	0.14452012
139	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.11507596
140	Galactose metabolism_Homo sapiens_hsa00052	0.11280419
141	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.11242394

HSPA8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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