HSPA8P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.67698575
2cytidine metabolic process (GO:0046087)5.33561110
3cytidine catabolic process (GO:0006216)5.33561110
4cytidine deamination (GO:0009972)5.33561110
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.05567227
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.81378591
7pyrimidine ribonucleoside catabolic process (GO:0046133)4.72312872
8proteasome assembly (GO:0043248)4.69181962
9regulation of cellular amino acid metabolic process (GO:0006521)4.17477178
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.13710122
11rRNA modification (GO:0000154)4.13094061
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.09470215
13ATP synthesis coupled proton transport (GO:0015986)4.04603047
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.04603047
15rRNA methylation (GO:0031167)3.94871156
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.94412071
17protein neddylation (GO:0045116)3.88615998
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.86493026
19signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.84757398
20signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.84757398
21signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.84757398
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.83087356
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.83087356
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.78314305
25cullin deneddylation (GO:0010388)3.76136436
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.70487447
27negative regulation of ligase activity (GO:0051352)3.70169322
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.70169322
29pseudouridine synthesis (GO:0001522)3.68765681
30signal transduction involved in DNA integrity checkpoint (GO:0072401)3.66952479
31signal transduction involved in DNA damage checkpoint (GO:0072422)3.66952479
32platelet dense granule organization (GO:0060155)3.64311714
33termination of RNA polymerase III transcription (GO:0006386)3.63414683
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.63414683
35signal transduction involved in cell cycle checkpoint (GO:0072395)3.61686123
36protein deneddylation (GO:0000338)3.59837762
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.47889936
38regulation of chronic inflammatory response (GO:0002676)3.47508710
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42532431
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42532431
41chaperone-mediated protein transport (GO:0072321)3.40084834
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.35903707
43maturation of 5.8S rRNA (GO:0000460)3.35110275
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33822719
45respiratory electron transport chain (GO:0022904)3.32880105
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31832571
47positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.30715950
48electron transport chain (GO:0022900)3.29530943
49antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.22396090
50positive regulation of ligase activity (GO:0051351)3.21518778
51respiratory chain complex IV assembly (GO:0008535)3.18210821
52water-soluble vitamin biosynthetic process (GO:0042364)3.16197235
53protein complex biogenesis (GO:0070271)3.14002118
54DNA double-strand break processing (GO:0000729)3.12539223
55signal peptide processing (GO:0006465)3.11743088
56positive regulation of cell cycle arrest (GO:0071158)3.05975093
57regulation of regulatory T cell differentiation (GO:0045589)3.03204382
58somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99582661
59somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99582661
60isotype switching (GO:0045190)2.99582661
61regulation of cellular amine metabolic process (GO:0033238)2.96584573
62mitochondrial respiratory chain complex assembly (GO:0033108)2.95928253
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94684501
64mitochondrial respiratory chain complex I assembly (GO:0032981)2.94684501
65NADH dehydrogenase complex assembly (GO:0010257)2.94684501
66DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.87877201
67protein-cofactor linkage (GO:0018065)2.86078953
68antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.83986796
69regulation of ubiquitin-protein transferase activity (GO:0051438)2.81869478
70cellular ketone body metabolic process (GO:0046950)2.79083375
71RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.78639118
72fucose catabolic process (GO:0019317)2.78383653
73L-fucose metabolic process (GO:0042354)2.78383653
74L-fucose catabolic process (GO:0042355)2.78383653
75peptidyl-histidine modification (GO:0018202)2.77662955
76ribosome assembly (GO:0042255)2.77650164
77regulation of ligase activity (GO:0051340)2.76330129
78regulation of isotype switching to IgG isotypes (GO:0048302)2.76018511
79DNA catabolic process, exonucleolytic (GO:0000738)2.73658229
80cellular response to interferon-beta (GO:0035458)2.70409046
81inner mitochondrial membrane organization (GO:0007007)2.69622238
82tRNA processing (GO:0008033)2.69104168
83cytochrome complex assembly (GO:0017004)2.66112990
84protein refolding (GO:0042026)2.64234789
85negative regulation of protein ubiquitination (GO:0031397)2.61823652
86positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.59789949
87rRNA processing (GO:0006364)2.57140102
88regulation of cell cycle arrest (GO:0071156)2.52381617
89protein targeting to mitochondrion (GO:0006626)2.51818490
90ketone body metabolic process (GO:1902224)2.51546413
91rRNA metabolic process (GO:0016072)2.51068143
92response to interferon-beta (GO:0035456)2.51012719
93protein localization to mitochondrion (GO:0070585)2.50727073
94negative regulation of cell cycle G1/S phase transition (GO:1902807)2.49793721
95negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.49793721
96histone mRNA metabolic process (GO:0008334)2.49167907
97establishment of protein localization to mitochondrion (GO:0072655)2.48247848
98positive regulation of interleukin-8 secretion (GO:2000484)2.47749775
99tRNA metabolic process (GO:0006399)2.47087342
100hydrogen ion transmembrane transport (GO:1902600)2.45511846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.03562795
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.35829767
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.69497237
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34896499
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.13305755
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02973298
7VDR_22108803_ChIP-Seq_LS180_Human3.01594829
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.98720078
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.94399510
10VDR_23849224_ChIP-Seq_CD4+_Human2.86664227
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86364523
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.64385491
13ELK1_19687146_ChIP-ChIP_HELA_Human2.47219463
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.38205042
15FOXP3_21729870_ChIP-Seq_TREG_Human2.31351069
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26594105
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23703731
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.18181382
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.09351328
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.09129955
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06214454
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02619904
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00047760
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99399951
25ZNF274_21170338_ChIP-Seq_K562_Hela1.97847188
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90699997
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89763315
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.86639355
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85278362
30IGF1R_20145208_ChIP-Seq_DFB_Human1.76784750
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71867115
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.71381914
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.71290687
34EWS_26573619_Chip-Seq_HEK293_Human1.68300400
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61721569
36MYC_18940864_ChIP-ChIP_HL60_Human1.61441916
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59658369
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57187934
39DCP1A_22483619_ChIP-Seq_HELA_Human1.49596854
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49146263
41TP53_22573176_ChIP-Seq_HFKS_Human1.47217472
42GATA3_26560356_Chip-Seq_TH2_Human1.40079089
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39627384
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38874628
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.38748484
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.37089509
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36740610
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34074883
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33490357
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.29924968
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26580891
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25988147
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.25988147
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22251219
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21747012
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20879166
57TTF2_22483619_ChIP-Seq_HELA_Human1.20838580
58FUS_26573619_Chip-Seq_HEK293_Human1.20464714
59E2F7_22180533_ChIP-Seq_HELA_Human1.20430091
60HTT_18923047_ChIP-ChIP_STHdh_Human1.20014996
61MYB_26560356_Chip-Seq_TH2_Human1.20007850
62SOX2_19829295_ChIP-Seq_ESCs_Human1.18327187
63NANOG_19829295_ChIP-Seq_ESCs_Human1.18327187
64P300_19829295_ChIP-Seq_ESCs_Human1.18322555
65GABP_19822575_ChIP-Seq_HepG2_Human1.17879375
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17865955
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15426043
68TAF15_26573619_Chip-Seq_HEK293_Human1.15048013
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.14237633
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13405336
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10172378
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07396061
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07303755
74ER_23166858_ChIP-Seq_MCF-7_Human1.07115441
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07102981
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03856245
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03805767
78AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03631337
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03266049
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02378452
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02143783
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01973795
83AR_20517297_ChIP-Seq_VCAP_Human1.01712187
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.99983183
85CRX_20693478_ChIP-Seq_RETINA_Mouse0.98197512
86RBPJ_21746931_ChIP-Seq_IB4_Human0.98011711
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97946093
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96946813
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95687573
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94211675
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.94004359
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91931726
93NCOR_22424771_ChIP-Seq_293T_Human0.91748788
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91561427
95GATA3_27048872_Chip-Seq_THYMUS_Human0.91352234
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89459018
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89229547
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.87415061
99PHF8_20622853_ChIP-Seq_HELA_Human0.87278182
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87070049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.43930187
2MP0001835_abnormal_antigen_presentation3.31378985
3MP0009785_altered_susceptibility_to2.80823707
4MP0006072_abnormal_retinal_apoptosis2.55047150
5MP0002102_abnormal_ear_morphology2.48870191
6MP0003806_abnormal_nucleotide_metabolis2.23776310
7MP0002166_altered_tumor_susceptibility2.22053180
8MP0008875_abnormal_xenobiotic_pharmacok2.17312157
9MP0004147_increased_porphyrin_level2.17229610
10MP0000685_abnormal_immune_system2.15536950
11MP0008058_abnormal_DNA_repair2.02490070
12MP0002837_dystrophic_cardiac_calcinosis2.01504928
13MP0001873_stomach_inflammation1.99547214
14MP0009333_abnormal_splenocyte_physiolog1.97140575
15MP0002006_tumorigenesis1.94372119
16MP0002148_abnormal_hypersensitivity_rea1.91791490
17MP0005645_abnormal_hypothalamus_physiol1.89034980
18MP0003763_abnormal_thymus_physiology1.77505577
19MP0003786_premature_aging1.77272406
20MP0001800_abnormal_humoral_immune1.73653849
21MP0008872_abnormal_physiological_respon1.71346829
22MP0002876_abnormal_thyroid_physiology1.68313457
23MP0005000_abnormal_immune_tolerance1.67093966
24MP0005387_immune_system_phenotype1.65374564
25MP0001790_abnormal_immune_system1.65374564
26MP0001188_hyperpigmentation1.62557838
27MP0003195_calcinosis1.62412366
28MP0006036_abnormal_mitochondrial_physio1.61296854
29MP0010094_abnormal_chromosome_stability1.58026143
30MP0005075_abnormal_melanosome_morpholog1.52057601
31MP0000372_irregular_coat_pigmentation1.51997337
32MP0003011_delayed_dark_adaptation1.49228543
33MP0006035_abnormal_mitochondrial_morpho1.46765845
34MP0002723_abnormal_immune_serum1.45261964
35MP0004957_abnormal_blastocyst_morpholog1.45087036
36MP0009697_abnormal_copulation1.44210039
37MP0005551_abnormal_eye_electrophysiolog1.43066550
38MP0004145_abnormal_muscle_electrophysio1.42655559
39MP0004142_abnormal_muscle_tone1.41645709
40MP0008877_abnormal_DNA_methylation1.39240544
41MP0002420_abnormal_adaptive_immunity1.37181192
42MP0003186_abnormal_redox_activity1.35061653
43MP0003718_maternal_effect1.34765493
44MP0001819_abnormal_immune_cell1.33867204
45MP0005253_abnormal_eye_physiology1.29014466
46MP0005389_reproductive_system_phenotype1.28904359
47MP0005084_abnormal_gallbladder_morpholo1.28757719
48MP0001501_abnormal_sleep_pattern1.27362102
49MP0006082_CNS_inflammation1.26626580
50MP0005025_abnormal_response_to1.25356544
51MP0003866_abnormal_defecation1.24611693
52MP0002452_abnormal_antigen_presenting1.23985962
53MP0001919_abnormal_reproductive_system1.22952485
54MP0001853_heart_inflammation1.21688971
55MP0001905_abnormal_dopamine_level1.17151983
56MP0003646_muscle_fatigue1.17130478
57MP0005646_abnormal_pituitary_gland1.13344369
58MP0002398_abnormal_bone_marrow1.12119164
59MP0002736_abnormal_nociception_after1.10139129
60MP0000689_abnormal_spleen_morphology1.09775951
61MP0003693_abnormal_embryo_hatching1.09619518
62MP0002277_abnormal_respiratory_mucosa1.08424078
63MP0009379_abnormal_foot_pigmentation1.08248607
64MP0001986_abnormal_taste_sensitivity1.07547876
65MP0009764_decreased_sensitivity_to1.07307182
66MP0005636_abnormal_mineral_homeostasis1.07227027
67MP0002693_abnormal_pancreas_physiology1.07134730
68MP0010155_abnormal_intestine_physiology1.06738963
69MP0001845_abnormal_inflammatory_respons1.02558496
70MP0000716_abnormal_immune_system1.02100502
71MP0005174_abnormal_tail_pigmentation1.01773439
72MP0002095_abnormal_skin_pigmentation1.00626753
73MP0005379_endocrine/exocrine_gland_phen1.00049676
74MP0001968_abnormal_touch/_nociception0.97332464
75MP0000015_abnormal_ear_pigmentation0.96852897
76MP0002138_abnormal_hepatobiliary_system0.95122372
77MP0002405_respiratory_system_inflammati0.94768678
78MP0001764_abnormal_homeostasis0.94757622
79MP0008007_abnormal_cellular_replicative0.94127207
80MP0000703_abnormal_thymus_morphology0.93880508
81MP0002272_abnormal_nervous_system0.93847874
82MP0004885_abnormal_endolymph0.93153746
83MP0001485_abnormal_pinna_reflex0.91931663
84MP0001529_abnormal_vocalization0.89864452
85MP0002160_abnormal_reproductive_system0.88932770
86MP0002429_abnormal_blood_cell0.88789196
87MP0002722_abnormal_immune_system0.88506780
88MP0009046_muscle_twitch0.86932781
89MP0005310_abnormal_salivary_gland0.86763520
90MP0008469_abnormal_protein_level0.85666884
91MP0005332_abnormal_amino_acid0.85095910
92MP0005410_abnormal_fertilization0.84253084
93MP0002254_reproductive_system_inflammat0.83861051
94MP0002933_joint_inflammation0.83767113
95MP0003448_altered_tumor_morphology0.83189200
96MP0010386_abnormal_urinary_bladder0.80298264
97MP0002751_abnormal_autonomic_nervous0.79199571
98MP0002163_abnormal_gland_morphology0.78192899
99MP0005085_abnormal_gallbladder_physiolo0.77915007
100MP0005360_urolithiasis0.77667263

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.54604127
2Mitochondrial inheritance (HP:0001427)4.03125631
3Acute encephalopathy (HP:0006846)4.01658234
4Increased CSF lactate (HP:0002490)3.95616509
5Abnormal mitochondria in muscle tissue (HP:0008316)3.93639447
6Progressive macrocephaly (HP:0004481)3.91774238
7Aplastic anemia (HP:0001915)3.90466741
8IgG deficiency (HP:0004315)3.83093104
93-Methylglutaconic aciduria (HP:0003535)3.63815739
10Hepatocellular necrosis (HP:0001404)3.62285928
11Increased hepatocellular lipid droplets (HP:0006565)3.54818933
12Lipid accumulation in hepatocytes (HP:0006561)3.45629043
13Hepatic necrosis (HP:0002605)3.43623564
14Stomatitis (HP:0010280)3.29846543
15Hypoproteinemia (HP:0003075)3.27193105
16T lymphocytopenia (HP:0005403)3.19050345
17Cerebral edema (HP:0002181)3.18688789
18Abnormality of T cell number (HP:0011839)3.04883338
19Severe combined immunodeficiency (HP:0004430)3.03681869
20Increased serum lactate (HP:0002151)2.94381788
21Hypothermia (HP:0002045)2.87944890
22Methylmalonic acidemia (HP:0002912)2.75370319
23Congenital stationary night blindness (HP:0007642)2.71531760
24Increased IgM level (HP:0003496)2.67354540
25Elevated erythrocyte sedimentation rate (HP:0003565)2.66384417
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.65215721
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.65215721
28Lactic acidosis (HP:0003128)2.64197253
29Renal Fanconi syndrome (HP:0001994)2.62955781
30Thyroiditis (HP:0100646)2.60244791
31Abnormality of B cell number (HP:0010975)2.56871705
32Abnormality of T cells (HP:0002843)2.52935591
33B lymphocytopenia (HP:0010976)2.49355552
34Abolished electroretinogram (ERG) (HP:0000550)2.49184023
35Lethargy (HP:0001254)2.49023431
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48992602
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.47781081
38Combined immunodeficiency (HP:0005387)2.45431664
39Methylmalonic aciduria (HP:0012120)2.44631179
40Pancytopenia (HP:0001876)2.43046880
41Pancreatic cysts (HP:0001737)2.42346757
42Optic disc pallor (HP:0000543)2.41886493
43Respiratory failure (HP:0002878)2.41638017
44Ketoacidosis (HP:0001993)2.40989796
45Abnormality of the prostate (HP:0008775)2.30763912
46Abnormality of midbrain morphology (HP:0002418)2.25650892
47Molar tooth sign on MRI (HP:0002419)2.25650892
48Increased intramyocellular lipid droplets (HP:0012240)2.24863012
49Degeneration of anterior horn cells (HP:0002398)2.21452621
50Abnormality of the anterior horn cell (HP:0006802)2.21452621
51Abnormality of the pons (HP:0007361)2.21173194
52Hypomagnesemia (HP:0002917)2.19424729
53Leukodystrophy (HP:0002415)2.18384694
54Congenital, generalized hypertrichosis (HP:0004540)2.18345239
55Type I transferrin isoform profile (HP:0003642)2.17279370
56True hermaphroditism (HP:0010459)2.16115482
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15085015
58Chronic diarrhea (HP:0002028)2.14922821
59Oral leukoplakia (HP:0002745)2.14836512
60Exertional dyspnea (HP:0002875)2.09918224
61Autoimmune hemolytic anemia (HP:0001890)2.05855955
62Decreased central vision (HP:0007663)2.05114489
63Pancreatic fibrosis (HP:0100732)2.04129516
64Large for gestational age (HP:0001520)2.03484968
65Exercise intolerance (HP:0003546)2.03147376
66Abnormal rod and cone electroretinograms (HP:0008323)2.02891386
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00164277
68Ketosis (HP:0001946)1.99289113
69Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98957126
70Renal cortical cysts (HP:0000803)1.97791070
71Abnormality of methionine metabolism (HP:0010901)1.95876891
72Tongue fasciculations (HP:0001308)1.94532787
73Generalized aminoaciduria (HP:0002909)1.94287650
74Abnormality of eosinophils (HP:0001879)1.94166352
75Hypoplasia of the pons (HP:0012110)1.93216015
76Pendular nystagmus (HP:0012043)1.92941171
77Chronic mucocutaneous candidiasis (HP:0002728)1.91850944
78Recurrent cutaneous fungal infections (HP:0011370)1.91850944
79Constricted visual fields (HP:0001133)1.90347839
80Abnormality of macular pigmentation (HP:0008002)1.89769505
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89700709
82Abnormality of alanine metabolism (HP:0010916)1.89700709
83Hyperalaninemia (HP:0003348)1.89700709
84Abnormal glycosylation (HP:0012345)1.88935307
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88935307
86Abnormal protein N-linked glycosylation (HP:0012347)1.88935307
87Abnormal protein glycosylation (HP:0012346)1.88935307
88Increased muscle lipid content (HP:0009058)1.88587958
89Palpitations (HP:0001962)1.87386409
90Type II lissencephaly (HP:0007260)1.87095145
91Abnormality of T cell physiology (HP:0011840)1.85598832
92Nephronophthisis (HP:0000090)1.84832455
93Abnormality of the renal cortex (HP:0011035)1.84401283
94Aplasia/hypoplasia of the uterus (HP:0008684)1.82167121
95Glycosuria (HP:0003076)1.81895020
96Abnormality of urine glucose concentration (HP:0011016)1.81895020
97Abnormality of magnesium homeostasis (HP:0004921)1.81758099
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79741977
99Dicarboxylic aciduria (HP:0003215)1.79741977
100Attenuation of retinal blood vessels (HP:0007843)1.79496433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.85313230
2TXK3.79392375
3MST43.61237179
4EIF2AK33.40302872
5VRK22.74860791
6ZAK2.40264412
7EIF2AK12.18026519
8TAOK32.12751028
9BUB12.03689776
10NEK12.01585869
11VRK12.00969632
12NUAK11.98494146
13MAP4K21.96443584
14BCKDK1.96017326
15TLK11.95140297
16KDR1.93488761
17TRIM281.87846182
18MAP3K121.84712283
19FRK1.82138992
20ADRBK21.76941301
21WNK41.60859494
22PLK31.55755304
23TESK21.53480951
24GRK11.52593498
25WNK31.49884915
26ITK1.39269461
27TAF11.36210110
28TEC1.35141677
29STK391.28726804
30SRPK11.28382625
31BMPR1B1.27894550
32PASK1.20619242
33MKNK21.16199886
34OXSR11.06562583
35MAP4K11.04711582
36WEE11.04217641
37MAP2K61.02704030
38PLK41.00474632
39EIF2AK20.95412922
40TIE10.92365735
41CSNK1G30.90517027
42BCR0.89375992
43TESK10.85223387
44PINK10.84956286
45STK160.83365273
46FES0.82846702
47ERBB30.81284448
48ACVR1B0.81121542
49PLK20.80562590
50CSNK1G10.80172847
51DAPK10.78581635
52SCYL20.78165742
53INSRR0.76247347
54MKNK10.76060719
55CSNK1G20.74967484
56NME10.72088388
57PRKCQ0.70419964
58PNCK0.68842160
59PIM20.68213563
60IKBKB0.66773987
61CSNK1A1L0.66272623
62RPS6KA40.64689768
63MYLK0.63675218
64CDC70.57149934
65SYK0.57062666
66RPS6KA50.56664467
67PLK10.56432062
68GRK70.56134287
69BMPR20.55631153
70LIMK10.55363129
71MAPKAPK50.53379133
72PBK0.52726713
73DYRK20.51331840
74KIT0.46459079
75TTK0.46291494
76MAP3K40.45887903
77STK38L0.42655379
78ADRBK10.42640863
79CCNB10.40787210
80LCK0.40670936
81MAPK150.39776377
82PRKCE0.39422678
83PHKG10.38540825
84PHKG20.38540825
85AKT30.38104436
86MAPKAPK30.37972138
87ATR0.37374881
88SIK30.36951261
89ALK0.36532835
90MAP2K70.35553688
91LYN0.34889457
92CSNK2A10.34737259
93CSNK2A20.34322120
94DAPK20.34133789
95TNIK0.32691595
96IGF1R0.29321141
97IKBKE0.27613635
98PRKCI0.27281678
99BRSK20.27092568
100BTK0.26675331

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.11923663
2Protein export_Homo sapiens_hsa030603.49238635
3Oxidative phosphorylation_Homo sapiens_hsa001903.25996485
4Parkinsons disease_Homo sapiens_hsa050122.76429521
5Primary immunodeficiency_Homo sapiens_hsa053402.71255610
6RNA polymerase_Homo sapiens_hsa030202.70062004
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50174457
8Allograft rejection_Homo sapiens_hsa053302.36386864
9Autoimmune thyroid disease_Homo sapiens_hsa053202.31871880
10Type I diabetes mellitus_Homo sapiens_hsa049402.24165658
11Asthma_Homo sapiens_hsa053102.07648097
12Graft-versus-host disease_Homo sapiens_hsa053322.00981827
13Antigen processing and presentation_Homo sapiens_hsa046121.93151327
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91696552
15Alzheimers disease_Homo sapiens_hsa050101.75350688
16Huntingtons disease_Homo sapiens_hsa050161.74782368
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.73440104
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72306145
19One carbon pool by folate_Homo sapiens_hsa006701.71735943
20Basal transcription factors_Homo sapiens_hsa030221.58656918
21Non-homologous end-joining_Homo sapiens_hsa034501.58501427
22RNA degradation_Homo sapiens_hsa030181.55828133
23Ribosome_Homo sapiens_hsa030101.53527102
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.52290475
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49531277
26Sulfur metabolism_Homo sapiens_hsa009201.48621562
27Mismatch repair_Homo sapiens_hsa034301.43975225
28Homologous recombination_Homo sapiens_hsa034401.39276883
29Propanoate metabolism_Homo sapiens_hsa006401.38292371
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33576098
31Caffeine metabolism_Homo sapiens_hsa002321.28972360
32RNA transport_Homo sapiens_hsa030131.28711300
33Rheumatoid arthritis_Homo sapiens_hsa053231.28575605
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24157204
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.23878930
36Hematopoietic cell lineage_Homo sapiens_hsa046401.23834157
37Pyrimidine metabolism_Homo sapiens_hsa002401.19665153
38Spliceosome_Homo sapiens_hsa030401.17795420
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13367614
40Phototransduction_Homo sapiens_hsa047441.11197168
41Butanoate metabolism_Homo sapiens_hsa006501.07108017
42Nucleotide excision repair_Homo sapiens_hsa034201.03590813
43DNA replication_Homo sapiens_hsa030301.03452116
44Linoleic acid metabolism_Homo sapiens_hsa005911.02617549
45Regulation of autophagy_Homo sapiens_hsa041401.01723197
46Collecting duct acid secretion_Homo sapiens_hsa049661.01392340
47Purine metabolism_Homo sapiens_hsa002300.97995964
48Cardiac muscle contraction_Homo sapiens_hsa042600.96569473
49Fatty acid elongation_Homo sapiens_hsa000620.93196274
50Folate biosynthesis_Homo sapiens_hsa007900.90211585
51Fanconi anemia pathway_Homo sapiens_hsa034600.89772768
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89046375
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85990624
54T cell receptor signaling pathway_Homo sapiens_hsa046600.85521494
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83785163
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81162380
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79458050
58Tryptophan metabolism_Homo sapiens_hsa003800.77253043
59Peroxisome_Homo sapiens_hsa041460.74788753
60Measles_Homo sapiens_hsa051620.67581949
61Nitrogen metabolism_Homo sapiens_hsa009100.66333416
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65201327
63Legionellosis_Homo sapiens_hsa051340.63816327
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62525550
65Selenocompound metabolism_Homo sapiens_hsa004500.60231988
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60173902
67Viral myocarditis_Homo sapiens_hsa054160.59218187
68Base excision repair_Homo sapiens_hsa034100.58758907
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58543516
70Epstein-Barr virus infection_Homo sapiens_hsa051690.57763822
71Ether lipid metabolism_Homo sapiens_hsa005650.56849088
72Metabolic pathways_Homo sapiens_hsa011000.55400590
73Sulfur relay system_Homo sapiens_hsa041220.53018696
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.51737145
75Vitamin B6 metabolism_Homo sapiens_hsa007500.51673277
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50008767
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.48437276
78Steroid biosynthesis_Homo sapiens_hsa001000.47820782
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45936536
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41777510
81Olfactory transduction_Homo sapiens_hsa047400.39939217
82Pyruvate metabolism_Homo sapiens_hsa006200.36427026
83Fatty acid metabolism_Homo sapiens_hsa012120.34835168
84Systemic lupus erythematosus_Homo sapiens_hsa053220.33761300
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33377118
86Chemical carcinogenesis_Homo sapiens_hsa052040.32911357
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32518163
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.32423406
89Retinol metabolism_Homo sapiens_hsa008300.31883739
90Glutathione metabolism_Homo sapiens_hsa004800.29415652
91Fatty acid degradation_Homo sapiens_hsa000710.28429349
92p53 signaling pathway_Homo sapiens_hsa041150.28176208
93Arachidonic acid metabolism_Homo sapiens_hsa005900.27935760
94Herpes simplex infection_Homo sapiens_hsa051680.26360385
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25973324
96Vitamin digestion and absorption_Homo sapiens_hsa049770.25502451
97beta-Alanine metabolism_Homo sapiens_hsa004100.25144454
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.22591826
99Fat digestion and absorption_Homo sapiens_hsa049750.21796582
100Mineral absorption_Homo sapiens_hsa049780.21389291

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »