ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	7.17347470
2	cytidine metabolic process (GO:0046087)	6.65462643
3	cytidine catabolic process (GO:0006216)	6.65462643
4	cytidine deamination (GO:0009972)	6.65462643
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.39205819
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.72913245
7	signal peptide processing (GO:0006465)	4.92162588
8	proteasome assembly (GO:0043248)	3.95422879
9	negative regulation by host of viral transcription (GO:0043922)	3.90022091
10	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.84686230
11	cullin deneddylation (GO:0010388)	3.80772144
12	protein deneddylation (GO:0000338)	3.79391411
13	regulation of cellular amino acid metabolic process (GO:0006521)	3.78192577
14	regulation of chronic inflammatory response (GO:0002676)	3.74568588
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.71324242
16	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.64148856
17	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.63604846
18	protein-cofactor linkage (GO:0018065)	3.61766193
19	protein K11-linked deubiquitination (GO:0035871)	3.55986277
20	actin nucleation (GO:0045010)	3.54764850
21	activated T cell proliferation (GO:0050798)	3.54675043
22	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.45940717
23	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.45184118
24	protein neddylation (GO:0045116)	3.44548409
25	cellular response to interleukin-15 (GO:0071350)	3.39692088
26	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.37261488
27	negative T cell selection (GO:0043383)	3.33813346
28	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.31504836
29	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.31504836
30	positive regulation of calcium-mediated signaling (GO:0050850)	3.30612114
31	iron-sulfur cluster assembly (GO:0016226)	3.30487830
32	metallo-sulfur cluster assembly (GO:0031163)	3.30487830
33	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.28753949
34	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.28753949
35	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.28753949
36	protein complex biogenesis (GO:0070271)	3.28467001
37	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.28095726
38	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.24354601
39	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.24153117
40	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.23564894
41	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.17652820
42	ATP synthesis coupled proton transport (GO:0015986)	3.17652820
43	regulation of T cell receptor signaling pathway (GO:0050856)	3.17102102
44	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.16413397
45	respiratory chain complex IV assembly (GO:0008535)	3.14856612
46	regulation of regulatory T cell differentiation (GO:0045589)	3.14434200
47	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.12600051
48	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.12027754
49	respiratory electron transport chain (GO:0022904)	3.11971435
50	electron transport chain (GO:0022900)	3.11588245
51	eosinophil chemotaxis (GO:0048245)	3.10567591
52	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.08523293
53	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.08523293
54	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.05815260
55	positive regulation of defense response to virus by host (GO:0002230)	3.04703746
56	mitochondrial respiratory chain complex assembly (GO:0033108)	3.04446993
57	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.03943925
58	cytolysis (GO:0019835)	3.01971958
59	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.94210305
60	cytochrome complex assembly (GO:0017004)	2.94113143
61	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.93446038
62	positive regulation of tolerance induction (GO:0002645)	2.92662734
63	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.88496484
64	regulation of natural killer cell mediated immunity (GO:0002715)	2.88496484
65	sequestering of actin monomers (GO:0042989)	2.87631486
66	interferon-gamma production (GO:0032609)	2.87587810
67	rRNA modification (GO:0000154)	2.87259488
68	adaptation of signaling pathway (GO:0023058)	2.86484472
69	positive regulation of cell killing (GO:0031343)	2.86257969
70	water-soluble vitamin biosynthetic process (GO:0042364)	2.85710023
71	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.85168074
72	serotonin receptor signaling pathway (GO:0007210)	2.84987340
73	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.84797001
74	negative regulation of ligase activity (GO:0051352)	2.84797001
75	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.84646305
76	negative regulation of T cell apoptotic process (GO:0070233)	2.84099230
77	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.84071528
78	eosinophil migration (GO:0072677)	2.82505181
79	positive regulation of cAMP-mediated signaling (GO:0043950)	2.82290430
80	tryptophan catabolic process (GO:0006569)	2.81434653
81	indole-containing compound catabolic process (GO:0042436)	2.81434653
82	indolalkylamine catabolic process (GO:0046218)	2.81434653
83	regulation of isotype switching to IgG isotypes (GO:0048302)	2.79495679
84	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.78467622
85	positive T cell selection (GO:0043368)	2.77883209
86	platelet dense granule organization (GO:0060155)	2.76877209
87	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.76449513
88	DNA double-strand break processing (GO:0000729)	2.75818658
89	regulation of T cell tolerance induction (GO:0002664)	2.75312717
90	sulfation (GO:0051923)	2.74237994
91	rRNA methylation (GO:0031167)	2.73944481
92	regulation of B cell receptor signaling pathway (GO:0050855)	2.72492637
93	T cell migration (GO:0072678)	2.71317717
94	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.70927630
95	regulation of cellular amine metabolic process (GO:0033238)	2.69548139
96	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.69326555
97	neuron fate determination (GO:0048664)	2.68842952
98	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.66623638
99	NADH dehydrogenase complex assembly (GO:0010257)	2.66623638
100	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.66623638

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.67120963
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.29912327
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.19474594
4	VDR_22108803_ChIP-Seq_LS180_Human	2.90559740
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.83718625
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.82653440
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.71327864
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.69652269
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.69105091
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.66088140
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.39785834
12	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.37688465
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.28791658
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.23264344
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.19723470
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.17871314
17	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.15249166
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.12790065
19	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.06604688
20	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.87040723
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.84260694
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.73927334
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.73505689
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.72325274
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.70285534
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.68541407
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.68170667
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65238973
29	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.64356552
30	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.63544972
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.61048675
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58715058
33	EWS_26573619_Chip-Seq_HEK293_Human	1.56790512
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.55997758
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54370830
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.53247113
37	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.52747540
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.52341534
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.52336725
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.50085302
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.50085302
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48910238
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46001419
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.42470733
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40871302
46	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.40562893
47	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.39171897
48	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.39003006
49	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.38469774
50	P300_19829295_ChIP-Seq_ESCs_Human	1.38240086
51	FUS_26573619_Chip-Seq_HEK293_Human	1.34989722
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34104967
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33056918
54	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.31853305
55	MYB_26560356_Chip-Seq_TH2_Human	1.30978068
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.30714406
57	HTT_18923047_ChIP-ChIP_STHdh_Human	1.29061207
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26214103
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25739354
60	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25194837
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24132277
62	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.21358870
63	GATA3_26560356_Chip-Seq_TH2_Human	1.20398779
64	NCOR_22424771_ChIP-Seq_293T_Human	1.18794430
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17033900
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17033900
67	RBPJ_21746931_ChIP-Seq_IB4_Human	1.16924590
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16339455
69	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16065125
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15219230
71	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.14910345
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12001168
73	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.11646078
74	GATA3_27048872_Chip-Seq_THYMUS_Human	1.11517685
75	PHF8_20622853_ChIP-Seq_HELA_Human	1.11072365
76	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10964209
77	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10578623
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.09453178
79	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08462253
80	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.07586526
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.07518705
82	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06786125
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05696401
84	EZH2_22144423_ChIP-Seq_EOC_Human	1.05377661
85	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.04802670
86	ETV1_20927104_ChIP-Seq_GIST48_Human	1.03093550
87	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01318115
88	CBP_20019798_ChIP-Seq_JUKART_Human	1.01318115
89	AR_20517297_ChIP-Seq_VCAP_Human	1.01232835
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00732809
91	DCP1A_22483619_ChIP-Seq_HELA_Human	1.00347409
92	TCF4_22108803_ChIP-Seq_LS180_Human	0.99737290
93	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.97187404
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96700846
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95999687
96	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.95706509
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95467580
98	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.94658878
99	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.94026720
100	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.93519852

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.51698891
2	MP0002102_abnormal_ear_morphology	3.14268448
3	MP0009785_altered_susceptibility_to	2.55485288
4	MP0010386_abnormal_urinary_bladder	2.37016170
5	MP0001873_stomach_inflammation	2.25459126
6	MP0003763_abnormal_thymus_physiology	2.18586708
7	MP0001968_abnormal_touch/_nociception	2.14074863
8	MP0009333_abnormal_splenocyte_physiolog	2.12140061
9	MP0005551_abnormal_eye_electrophysiolog	2.08967384
10	MP0003195_calcinosis	2.07280999
11	MP0008875_abnormal_xenobiotic_pharmacok	2.06902841
12	MP0002277_abnormal_respiratory_mucosa	2.05810251
13	MP0005387_immune_system_phenotype	1.97878190
14	MP0001790_abnormal_immune_system	1.97878190
15	MP0005645_abnormal_hypothalamus_physiol	1.97335030
16	MP0001835_abnormal_antigen_presentation	1.87012762
17	MP0005310_abnormal_salivary_gland	1.86988835
18	MP0008872_abnormal_physiological_respon	1.82646175
19	MP0002138_abnormal_hepatobiliary_system	1.82173006
20	MP0006072_abnormal_retinal_apoptosis	1.80765417
21	MP0001501_abnormal_sleep_pattern	1.79237690
22	MP0002876_abnormal_thyroid_physiology	1.72379469
23	MP0003806_abnormal_nucleotide_metabolis	1.70238854
24	MP0001905_abnormal_dopamine_level	1.68665358
25	MP0004147_increased_porphyrin_level	1.60523071
26	MP0006082_CNS_inflammation	1.60475710
27	MP0005000_abnormal_immune_tolerance	1.59774859
28	MP0002166_altered_tumor_susceptibility	1.59549051
29	MP0003866_abnormal_defecation	1.57008248
30	MP0002148_abnormal_hypersensitivity_rea	1.54801963
31	MP0005377_hearing/vestibular/ear_phenot	1.54036557
32	MP0003878_abnormal_ear_physiology	1.54036557
33	MP0002006_tumorigenesis	1.50214639
34	MP0001800_abnormal_humoral_immune	1.47715005
35	MP0002837_dystrophic_cardiac_calcinosis	1.41872172
36	MP0005084_abnormal_gallbladder_morpholo	1.40072816
37	MP0002736_abnormal_nociception_after	1.39407532
38	MP0002420_abnormal_adaptive_immunity	1.39373699
39	MP0001485_abnormal_pinna_reflex	1.37742878
40	MP0005085_abnormal_gallbladder_physiolo	1.37625619
41	MP0001984_abnormal_olfaction	1.37310039
42	MP0003786_premature_aging	1.36945863
43	MP0001819_abnormal_immune_cell	1.34244770
44	MP0000685_abnormal_immune_system	1.34125454
45	MP0002723_abnormal_immune_serum	1.32394892
46	MP0003252_abnormal_bile_duct	1.29159934
47	MP0005025_abnormal_response_to	1.27914588
48	MP0009745_abnormal_behavioral_response	1.24746218
49	MP0005253_abnormal_eye_physiology	1.24573760
50	MP0000372_irregular_coat_pigmentation	1.24171313
51	MP0002693_abnormal_pancreas_physiology	1.23323807
52	MP0002272_abnormal_nervous_system	1.22310732
53	MP0003880_abnormal_central_pattern	1.21930448
54	MP0008877_abnormal_DNA_methylation	1.19578119
55	MP0001986_abnormal_taste_sensitivity	1.18756143
56	MP0008058_abnormal_DNA_repair	1.13159921
57	MP0006276_abnormal_autonomic_nervous	1.12795472
58	MP0001764_abnormal_homeostasis	1.11744917
59	MP0005389_reproductive_system_phenotype	1.11402716
60	MP0001919_abnormal_reproductive_system	1.10609521
61	MP0010155_abnormal_intestine_physiology	1.08932728
62	MP0000716_abnormal_immune_system	1.08137069
63	MP0001348_abnormal_lacrimal_gland	1.05505972
64	MP0002452_abnormal_antigen_presenting	1.04867247
65	MP0006036_abnormal_mitochondrial_physio	1.02867091
66	MP0005360_urolithiasis	1.02624085
67	MP0004742_abnormal_vestibular_system	1.02521575
68	MP0001529_abnormal_vocalization	1.00876504
69	MP0001188_hyperpigmentation	1.00354008
70	MP0002933_joint_inflammation	0.98464084
71	MP0000703_abnormal_thymus_morphology	0.98016474
72	MP0002398_abnormal_bone_marrow	0.96413450
73	MP0003724_increased_susceptibility_to	0.94958579
74	MP0002405_respiratory_system_inflammati	0.94154693
75	MP0001845_abnormal_inflammatory_respons	0.93281649
76	MP0005075_abnormal_melanosome_morpholog	0.92082076
77	MP0000538_abnormal_urinary_bladder	0.92057633
78	MP0003137_abnormal_impulse_conducting	0.89747806
79	MP0001970_abnormal_pain_threshold	0.89535364
80	MP0001486_abnormal_startle_reflex	0.88740663
81	MP0005410_abnormal_fertilization	0.87644364
82	MP0002722_abnormal_immune_system	0.87538901
83	MP0002733_abnormal_thermal_nociception	0.87122367
84	MP0004924_abnormal_behavior	0.86108512
85	MP0005386_behavior/neurological_phenoty	0.86108512
86	MP0002160_abnormal_reproductive_system	0.85654725
87	MP0003183_abnormal_peptide_metabolism	0.84474056
88	MP0005646_abnormal_pituitary_gland	0.81881579
89	MP0000689_abnormal_spleen_morphology	0.81429248
90	MP0008057_abnormal_DNA_replication	0.81418550
91	MP0008007_abnormal_cellular_replicative	0.80480067
92	MP0003045_fibrosis	0.80215329
93	MP0005636_abnormal_mineral_homeostasis	0.79136520
94	MP0004043_abnormal_pH_regulation	0.78415398
95	MP0002735_abnormal_chemical_nociception	0.77757406
96	MP0005379_endocrine/exocrine_gland_phen	0.77518089
97	MP0004145_abnormal_muscle_electrophysio	0.77256011
98	MP0002429_abnormal_blood_cell	0.76888890
99	MP0002928_abnormal_bile_duct	0.76648316
100	MP0002064_seizures	0.76444812

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.89537042
2	Mitochondrial inheritance (HP:0001427)	3.82467600
3	Congenital stationary night blindness (HP:0007642)	3.74250903
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.65062708
5	IgG deficiency (HP:0004315)	3.64353956
6	T lymphocytopenia (HP:0005403)	3.55722357
7	Hepatocellular necrosis (HP:0001404)	3.53231301
8	Aplastic anemia (HP:0001915)	3.49105434
9	Acute encephalopathy (HP:0006846)	3.47173529
10	Increased CSF lactate (HP:0002490)	3.44472085
11	Abnormality of T cell number (HP:0011839)	3.44155171
12	Severe combined immunodeficiency (HP:0004430)	3.27474352
13	Stomatitis (HP:0010280)	3.27091254
14	Volvulus (HP:0002580)	3.26667871
15	Progressive macrocephaly (HP:0004481)	3.26532795
16	Hepatic necrosis (HP:0002605)	3.17785878
17	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.15232763
18	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.15232763
19	Autoimmune hemolytic anemia (HP:0001890)	3.01207047
20	Hypoproteinemia (HP:0003075)	3.00488977
21	3-Methylglutaconic aciduria (HP:0003535)	2.93186116
22	Thyroiditis (HP:0100646)	2.92156998
23	Pancreatic cysts (HP:0001737)	2.91420547
24	Urethral obstruction (HP:0000796)	2.80348880
25	Cerebral edema (HP:0002181)	2.79601058
26	Hypothermia (HP:0002045)	2.77811686
27	Optic disc pallor (HP:0000543)	2.69173977
28	Renal cortical cysts (HP:0000803)	2.68427279
29	Elevated erythrocyte sedimentation rate (HP:0003565)	2.67034254
30	Abnormality of T cells (HP:0002843)	2.66382833
31	Abnormality of B cell number (HP:0010975)	2.64438089
32	Abolished electroretinogram (ERG) (HP:0000550)	2.63282387
33	Attenuation of retinal blood vessels (HP:0007843)	2.59374707
34	Increased hepatocellular lipid droplets (HP:0006565)	2.59326070
35	Renal Fanconi syndrome (HP:0001994)	2.59039404
36	Lipid accumulation in hepatocytes (HP:0006561)	2.58197595
37	Chronic bronchitis (HP:0004469)	2.57268801
38	Increased IgM level (HP:0003496)	2.56310746
39	B lymphocytopenia (HP:0010976)	2.49138788
40	Autoimmune thrombocytopenia (HP:0001973)	2.48290834
41	Constricted visual fields (HP:0001133)	2.48075746
42	Combined immunodeficiency (HP:0005387)	2.44306504
43	Generalized aminoaciduria (HP:0002909)	2.43133231
44	Abnormality of the prostate (HP:0008775)	2.39724490
45	Increased intramyocellular lipid droplets (HP:0012240)	2.37098412
46	True hermaphroditism (HP:0010459)	2.35572174
47	Pancytopenia (HP:0001876)	2.33846722
48	Increased serum lactate (HP:0002151)	2.32800771
49	Lactic acidosis (HP:0003128)	2.30270348
50	Methylmalonic acidemia (HP:0002912)	2.29673887
51	Abnormality of eosinophils (HP:0001879)	2.27691080
52	Congenital, generalized hypertrichosis (HP:0004540)	2.23646206
53	Chronic diarrhea (HP:0002028)	2.22701681
54	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.19734720
55	Methylmalonic aciduria (HP:0012120)	2.19105790
56	Encephalitis (HP:0002383)	2.18303296
57	Congenital sensorineural hearing impairment (HP:0008527)	2.18061127
58	Keratoconjunctivitis (HP:0001096)	2.14242276
59	Optic neuritis (HP:0100653)	2.13771702
60	Retrobulbar optic neuritis (HP:0100654)	2.13771702
61	Respiratory failure (HP:0002878)	2.12620087
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.09652925
63	Lymphopenia (HP:0001888)	2.08671403
64	Lethargy (HP:0001254)	2.08531909
65	Decreased circulating renin level (HP:0003351)	2.07727956
66	Pancreatic fibrosis (HP:0100732)	2.07235589
67	Abnormal albumin level (HP:0012116)	2.02919398
68	Hypoalbuminemia (HP:0003073)	2.02919398
69	Abnormality of midbrain morphology (HP:0002418)	2.02125837
70	Molar tooth sign on MRI (HP:0002419)	2.02125837
71	Increased muscle lipid content (HP:0009058)	2.01866079
72	Abnormal rod and cone electroretinograms (HP:0008323)	2.00023601
73	Short tibia (HP:0005736)	1.99580601
74	Bronchitis (HP:0012387)	1.97172999
75	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.95233656
76	Pendular nystagmus (HP:0012043)	1.93366591
77	Neuroendocrine neoplasm (HP:0100634)	1.92977456
78	IgM deficiency (HP:0002850)	1.92218900
79	Decreased central vision (HP:0007663)	1.92030705
80	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.90832758
81	Pheochromocytoma (HP:0002666)	1.90536398
82	Asplenia (HP:0001746)	1.87781316
83	Glycosuria (HP:0003076)	1.87622029
84	Abnormality of urine glucose concentration (HP:0011016)	1.87622029
85	Abnormality of the renal cortex (HP:0011035)	1.87343578
86	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.85757770
87	Type 2 muscle fiber atrophy (HP:0003554)	1.81725823
88	Hyperglycinemia (HP:0002154)	1.81656520
89	Type I transferrin isoform profile (HP:0003642)	1.76597705
90	Aplasia/hypoplasia of the uterus (HP:0008684)	1.74584061
91	Large for gestational age (HP:0001520)	1.73587552
92	Leukodystrophy (HP:0002415)	1.73207834
93	Hyperglycinuria (HP:0003108)	1.71576128
94	Keratoconjunctivitis sicca (HP:0001097)	1.70040295
95	Eosinophilia (HP:0001880)	1.69447579
96	Abnormality of T cell physiology (HP:0011840)	1.68427161
97	Opisthotonus (HP:0002179)	1.66128191
98	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.65431628
99	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.65289294
100	Nephronophthisis (HP:0000090)	1.64698602

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.17867241
2	TSSK6	3.69411990
3	ADRBK2	3.36093265
4	FRK	3.13653686
5	KDR	3.08626302
6	MAP4K2	2.49055602
7	VRK2	2.44146976
8	TLK1	2.42226679
9	TESK2	2.41842754
10	MAP4K1	2.26829987
11	MAP3K9	2.22462593
12	TAF1	2.08279066
13	BCKDK	1.99655116
14	TAOK3	1.94571320
15	MST4	1.91749688
16	BUB1	1.90008665
17	NEK1	1.88253811
18	VRK1	1.86641991
19	ZAK	1.86522227
20	MAP3K12	1.82929250
21	WNK3	1.76560976
22	WNK4	1.67178494
23	GRK1	1.59845957
24	ITK	1.47286303
25	EIF2AK3	1.41740778
26	CASK	1.41232963
27	LIMK1	1.41109747
28	MARK1	1.38294588
29	TRIM28	1.27625015
30	STK39	1.26664615
31	OXSR1	1.24844335
32	SCYL2	1.22480330
33	PINK1	1.21290356
34	BCR	1.11087206
35	NUAK1	1.09535804
36	TESK1	1.09404854
37	PASK	1.06670252
38	ERBB3	0.97355453
39	PIK3CG	0.94036599
40	TEC	0.92221662
41	CSNK1G3	0.89621147
42	MUSK	0.88644705
43	CSNK1G2	0.87852960
44	INSRR	0.87818143
45	BMPR1B	0.87546655
46	MAPK13	0.86641462
47	ADRBK1	0.86200629
48	IKBKB	0.84539694
49	TIE1	0.84054968
50	PRKCQ	0.82169326
51	MAPKAPK3	0.79214514
52	CSK	0.75489457
53	CSNK1G1	0.74323037
54	DAPK1	0.72528876
55	GRK6	0.72448213
56	FES	0.70426694
57	MAPKAPK5	0.68488499
58	PLK3	0.67046795
59	IKBKE	0.66753085
60	MYLK	0.66571940
61	SYK	0.63994676
62	CSNK1A1L	0.62150710
63	LCK	0.61082791
64	CAMK2A	0.60023321
65	NME1	0.59666326
66	PRKCE	0.59022180
67	SRPK1	0.54842593
68	MAP2K6	0.53352528
69	MATK	0.52930087
70	GRK5	0.50553464
71	GRK7	0.50467171
72	CSF1R	0.48190935
73	DYRK2	0.47047138
74	IGF1R	0.46983326
75	STK16	0.45663832
76	ACVR1B	0.44832282
77	EIF2AK2	0.42567830
78	CSNK1A1	0.40332245
79	BTK	0.40285288
80	LYN	0.40096943
81	MAP2K7	0.39517644
82	RPS6KA5	0.39260695
83	PRKCG	0.39040325
84	PRKCA	0.38474031
85	CLK1	0.37510513
86	PBK	0.36962516
87	MKNK1	0.36840491
88	PRKACA	0.34317262
89	OBSCN	0.32717200
90	MAPK15	0.32467914
91	PLK2	0.31315923
92	TBK1	0.30810052
93	CSNK2A1	0.30642031
94	CSNK2A2	0.30106358
95	PIK3CA	0.29706287
96	PRKCB	0.28590568
97	STK38L	0.28061490
98	EIF2AK1	0.25864645
99	ZAP70	0.23814557
100	PRKCH	0.23259747

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.02937114
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.97016439
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.29787251
4	Protein export_Homo sapiens_hsa03060	2.96487289
5	Parkinsons disease_Homo sapiens_hsa05012	2.83106098
6	RNA polymerase_Homo sapiens_hsa03020	2.04689822
7	Antigen processing and presentation_Homo sapiens_hsa04612	1.96946002
8	Phototransduction_Homo sapiens_hsa04744	1.92738600
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.87577212
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.84905772
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.83235290
12	Huntingtons disease_Homo sapiens_hsa05016	1.80344919
13	Allograft rejection_Homo sapiens_hsa05330	1.78370002
14	Alzheimers disease_Homo sapiens_hsa05010	1.71935357
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.70278615
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.65991177
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.62094068
18	Propanoate metabolism_Homo sapiens_hsa00640	1.58736237
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.54874898
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.51007756
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.47977968
22	Basal transcription factors_Homo sapiens_hsa03022	1.47889816
23	Butanoate metabolism_Homo sapiens_hsa00650	1.47059174
24	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.44248068
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.35664156
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.35346321
27	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.34922777
28	Sulfur metabolism_Homo sapiens_hsa00920	1.33215518
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.32109738
30	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.31812161
31	Nicotine addiction_Homo sapiens_hsa05033	1.29480890
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.28137654
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.25858945
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.23873378
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.21622047
36	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.21179417
37	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.20881538
38	One carbon pool by folate_Homo sapiens_hsa00670	1.18735761
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.15746235
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.15200719
41	Taste transduction_Homo sapiens_hsa04742	1.06671442
42	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.03261904
43	RNA degradation_Homo sapiens_hsa03018	1.01827790
44	Homologous recombination_Homo sapiens_hsa03440	0.98219041
45	Selenocompound metabolism_Homo sapiens_hsa00450	0.96956000
46	Rheumatoid arthritis_Homo sapiens_hsa05323	0.96308190
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92702120
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92458812
49	Ribosome_Homo sapiens_hsa03010	0.92227555
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.86311951
51	Caffeine metabolism_Homo sapiens_hsa00232	0.86078674
52	RNA transport_Homo sapiens_hsa03013	0.85413208
53	Fanconi anemia pathway_Homo sapiens_hsa03460	0.82299946
54	Spliceosome_Homo sapiens_hsa03040	0.80735016
55	Asthma_Homo sapiens_hsa05310	0.79858339
56	Measles_Homo sapiens_hsa05162	0.78430653
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.77540561
58	Purine metabolism_Homo sapiens_hsa00230	0.76525637
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76036737
60	Peroxisome_Homo sapiens_hsa04146	0.72418928
61	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.72084476
62	Olfactory transduction_Homo sapiens_hsa04740	0.71304869
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69197373
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.68689349
65	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.68339458
66	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.66555396
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.65156055
68	Mismatch repair_Homo sapiens_hsa03430	0.64205841
69	Retinol metabolism_Homo sapiens_hsa00830	0.62629008
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62059612
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.61092506
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58848002
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55250393
74	Metabolic pathways_Homo sapiens_hsa01100	0.55074220
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53385843
76	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.53103156
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52164632
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52090308
79	Morphine addiction_Homo sapiens_hsa05032	0.51245478
80	Legionellosis_Homo sapiens_hsa05134	0.50068536
81	Nucleotide excision repair_Homo sapiens_hsa03420	0.49212159
82	Fatty acid degradation_Homo sapiens_hsa00071	0.47329384
83	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.46723677
84	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.45767196
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45688079
86	Histidine metabolism_Homo sapiens_hsa00340	0.45487871
87	Regulation of autophagy_Homo sapiens_hsa04140	0.43925254
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42549284
89	Fatty acid elongation_Homo sapiens_hsa00062	0.42278864
90	DNA replication_Homo sapiens_hsa03030	0.41377371
91	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.40326438
92	Salivary secretion_Homo sapiens_hsa04970	0.39811369
93	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.36341415
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33776271
95	Mineral absorption_Homo sapiens_hsa04978	0.32747536
96	GABAergic synapse_Homo sapiens_hsa04727	0.32292371
97	Insulin secretion_Homo sapiens_hsa04911	0.32176212
98	Base excision repair_Homo sapiens_hsa03410	0.32103777
99	Folate biosynthesis_Homo sapiens_hsa00790	0.30734282
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.29472886

HSPA8P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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