ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K6-linked ubiquitination (GO:0085020)	4.96626406
2	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.82604867
3	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.82604867
4	NADH dehydrogenase complex assembly (GO:0010257)	4.82604867
5	water-soluble vitamin biosynthetic process (GO:0042364)	4.68501811
6	DNA deamination (GO:0045006)	4.65229766
7	proteasome assembly (GO:0043248)	4.58129832
8	mitochondrial respiratory chain complex assembly (GO:0033108)	4.36747704
9	regulation of chronic inflammatory response (GO:0002676)	4.30134520
10	protein complex biogenesis (GO:0070271)	4.28821530
11	mitotic sister chromatid cohesion (GO:0007064)	3.92502380
12	regulation of isotype switching to IgG isotypes (GO:0048302)	3.86636850
13	cullin deneddylation (GO:0010388)	3.82931072
14	positive regulation of action potential (GO:0045760)	3.70322456
15	regulation of DNA endoreduplication (GO:0032875)	3.68459038
16	regulation of action potential (GO:0098900)	3.56943473
17	behavioral response to nicotine (GO:0035095)	3.56671558
18	regulation of response to tumor cell (GO:0002834)	3.42860392
19	positive regulation of response to tumor cell (GO:0002836)	3.42860392
20	positive regulation of immune response to tumor cell (GO:0002839)	3.42860392
21	regulation of immune response to tumor cell (GO:0002837)	3.42860392
22	activated T cell proliferation (GO:0050798)	3.35321816
23	piRNA metabolic process (GO:0034587)	3.33867320
24	protein deneddylation (GO:0000338)	3.33661440
25	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.20168581
26	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.17931761
27	termination of RNA polymerase III transcription (GO:0006386)	3.16954342
28	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.16954342
29	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.14575559
30	fusion of sperm to egg plasma membrane (GO:0007342)	3.14383191
31	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.12324664
32	mitochondrial RNA metabolic process (GO:0000959)	3.11192746
33	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.10956055
34	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.10065726
35	rRNA modification (GO:0000154)	3.08516402
36	negative regulation of thymocyte apoptotic process (GO:0070244)	3.08490383
37	protein neddylation (GO:0045116)	3.08148109
38	rRNA methylation (GO:0031167)	3.07573702
39	termination of RNA polymerase I transcription (GO:0006363)	3.06265788
40	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.04828530
41	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.02884430
42	ribosome assembly (GO:0042255)	3.02819312
43	chaperone-mediated protein transport (GO:0072321)	2.99984870
44	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.99286032
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.99220097
46	regulation of cellular amino acid metabolic process (GO:0006521)	2.98421862
47	7-methylguanosine mRNA capping (GO:0006370)	2.98344794
48	DNA replication checkpoint (GO:0000076)	2.96864512
49	tolerance induction (GO:0002507)	2.96176680
50	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.95797928
51	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.95797928
52	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.95797928
53	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.94124517
54	musculoskeletal movement (GO:0050881)	2.93600192
55	multicellular organismal movement (GO:0050879)	2.93600192
56	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.91439923
57	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.91439923
58	7-methylguanosine RNA capping (GO:0009452)	2.91191579
59	RNA capping (GO:0036260)	2.91191579
60	regulation of regulatory T cell differentiation (GO:0045589)	2.89011691
61	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.87013348
62	primary amino compound metabolic process (GO:1901160)	2.86347756
63	DNA catabolic process, exonucleolytic (GO:0000738)	2.84296435
64	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.83968950
65	platelet dense granule organization (GO:0060155)	2.83740261
66	protein refolding (GO:0042026)	2.81908576
67	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.80868988
68	regulation of acrosome reaction (GO:0060046)	2.80813287
69	reflex (GO:0060004)	2.78526730
70	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.78199510
71	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.78199510
72	regulation of thymocyte apoptotic process (GO:0070243)	2.77334548
73	GMP metabolic process (GO:0046037)	2.76861644
74	positive regulation of cell cycle arrest (GO:0071158)	2.73312050
75	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.70340209
76	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.69105198
77	DNA double-strand break processing (GO:0000729)	2.68133866
78	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.67987525
79	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.64598566
80	negative regulation of ligase activity (GO:0051352)	2.64598566
81	T cell mediated immunity (GO:0002456)	2.62010192
82	pseudouridine synthesis (GO:0001522)	2.61558109
83	protein-cofactor linkage (GO:0018065)	2.57945740
84	L-methionine salvage (GO:0071267)	2.54402642
85	L-methionine biosynthetic process (GO:0071265)	2.54402642
86	amino acid salvage (GO:0043102)	2.54402642
87	postreplication repair (GO:0006301)	2.54048922
88	hepatocyte apoptotic process (GO:0097284)	2.53416090
89	positive regulation of defense response to virus by host (GO:0002230)	2.52663676
90	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.51466131
91	sympathetic nervous system development (GO:0048485)	2.51383717
92	signal peptide processing (GO:0006465)	2.49276322
93	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.49182648
94	myelin assembly (GO:0032288)	2.49076538
95	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.47196021
96	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.45841731
97	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.44962366
98	positive regulation of ligase activity (GO:0051351)	2.43930981
99	resolution of meiotic recombination intermediates (GO:0000712)	2.43555325
100	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.42236998

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.26505588
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.06586186
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.74252590
4	VDR_22108803_ChIP-Seq_LS180_Human	3.15267659
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.14826638
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.99227194
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.94883978
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.69205268
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.68188150
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.65550573
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.63708914
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.57195107
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.54827226
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.42770404
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.41283609
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.41020686
17	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.39192834
18	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.27915146
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.25865533
20	ZNF274_21170338_ChIP-Seq_K562_Hela	2.21474704
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20402159
22	EWS_26573619_Chip-Seq_HEK293_Human	2.08426638
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.87097248
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.84026095
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.82462731
26	E2F7_22180533_ChIP-Seq_HELA_Human	1.81428048
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.81146371
28	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.78129985
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.75811986
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.68098207
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.65345472
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.63791741
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.62308050
34	FUS_26573619_Chip-Seq_HEK293_Human	1.58347240
35	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.54647304
36	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.52157933
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.51962072
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.49594138
39	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.49255474
40	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.49237927
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49195034
42	P300_19829295_ChIP-Seq_ESCs_Human	1.47132545
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.45912091
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38694593
45	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.32922610
46	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.32845476
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.32551479
48	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.31951986
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25314442
50	DCP1A_22483619_ChIP-Seq_HELA_Human	1.23819885
51	GABP_19822575_ChIP-Seq_HepG2_Human	1.21029040
52	TAF15_26573619_Chip-Seq_HEK293_Human	1.19303039
53	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.18545516
54	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.17965953
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.15067946
56	GATA3_26560356_Chip-Seq_TH2_Human	1.15005737
57	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.14658461
58	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.11932034
59	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.09023069
60	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.06464277
61	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02711859
62	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02560334
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01565642
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01565642
65	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.00557145
66	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.00026011
67	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99669433
68	GBX2_23144817_ChIP-Seq_PC3_Human	0.99450719
69	TTF2_22483619_ChIP-Seq_HELA_Human	0.99291760
70	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96654792
71	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.96188905
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95600826
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95600826
74	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95500738
75	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.95238483
76	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.94431429
77	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.94257523
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.93872837
79	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.93788498
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92079637
81	EZH2_22144423_ChIP-Seq_EOC_Human	0.91654620
82	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.90635781
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.89739984
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.89676227
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.88891484
86	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.87882304
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.87655679
88	CBP_21632823_ChIP-Seq_H3396_Human	0.87472914
89	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.87361160
90	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.87199501
91	P300_18555785_Chip-Seq_ESCs_Mouse	0.86361753
92	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.85850821
93	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.85537993
94	STAT3_23295773_ChIP-Seq_U87_Human	0.85112965
95	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.85010427
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.84565842
97	SMAD4_21799915_ChIP-Seq_A2780_Human	0.84223358
98	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.84187850
99	ELF5_23300383_ChIP-Seq_T47D_Human	0.84055971
100	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.83599525

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001873_stomach_inflammation	4.54480622
2	MP0008057_abnormal_DNA_replication	3.64870225
3	MP0005670_abnormal_white_adipose	3.15409263
4	MP0002163_abnormal_gland_morphology	3.14330609
5	MP0008877_abnormal_DNA_methylation	2.88723342
6	MP0002876_abnormal_thyroid_physiology	2.77771877
7	MP0004885_abnormal_endolymph	2.70521265
8	MP0000569_abnormal_digit_pigmentation	2.68999550
9	MP0002138_abnormal_hepatobiliary_system	2.59608237
10	MP0002254_reproductive_system_inflammat	2.23039120
11	MP0008872_abnormal_physiological_respon	2.16814435
12	MP0002102_abnormal_ear_morphology	2.05213704
13	MP0000685_abnormal_immune_system	2.04319741
14	MP0002095_abnormal_skin_pigmentation	2.03044649
15	MP0005379_endocrine/exocrine_gland_phen	2.01801563
16	MP0006072_abnormal_retinal_apoptosis	1.89189637
17	MP0001984_abnormal_olfaction	1.87056427
18	MP0002166_altered_tumor_susceptibility	1.83988578
19	MP0008058_abnormal_DNA_repair	1.79173084
20	MP0010094_abnormal_chromosome_stability	1.68707848
21	MP0002006_tumorigenesis	1.68375096
22	MP0002277_abnormal_respiratory_mucosa	1.67226636
23	MP0003195_calcinosis	1.58766582
24	MP0000015_abnormal_ear_pigmentation	1.57784297
25	MP0001835_abnormal_antigen_presentation	1.57262493
26	MP0005387_immune_system_phenotype	1.55485317
27	MP0001790_abnormal_immune_system	1.55485317
28	MP0005671_abnormal_response_to	1.48418548
29	MP0004215_abnormal_myocardial_fiber	1.47375948
30	MP0000372_irregular_coat_pigmentation	1.47359757
31	MP0005645_abnormal_hypothalamus_physiol	1.46739043
32	MP0009745_abnormal_behavioral_response	1.45597097
33	MP0006035_abnormal_mitochondrial_morpho	1.44946627
34	MP0008875_abnormal_xenobiotic_pharmacok	1.44454997
35	MP0004142_abnormal_muscle_tone	1.43425962
36	MP0001485_abnormal_pinna_reflex	1.42413147
37	MP0004147_increased_porphyrin_level	1.40467374
38	MP0005084_abnormal_gallbladder_morpholo	1.39829057
39	MP0004957_abnormal_blastocyst_morpholog	1.39026294
40	MP0004134_abnormal_chest_morphology	1.34936685
41	MP0000427_abnormal_hair_cycle	1.32790843
42	MP0001879_abnormal_lymphatic_vessel	1.31836730
43	MP0002148_abnormal_hypersensitivity_rea	1.28619835
44	MP0001348_abnormal_lacrimal_gland	1.27219531
45	MP0010678_abnormal_skin_adnexa	1.20281841
46	MP0005551_abnormal_eye_electrophysiolog	1.19676638
47	MP0003806_abnormal_nucleotide_metabolis	1.17240778
48	MP0000383_abnormal_hair_follicle	1.17155916
49	MP0003077_abnormal_cell_cycle	1.16826622
50	MP0004133_heterotaxia	1.16825586
51	MP0005377_hearing/vestibular/ear_phenot	1.16508372
52	MP0003878_abnormal_ear_physiology	1.16508372
53	MP0003693_abnormal_embryo_hatching	1.12497339
54	MP0002751_abnormal_autonomic_nervous	1.12071774
55	MP0001486_abnormal_startle_reflex	1.11724601
56	MP0003943_abnormal_hepatobiliary_system	1.10427675
57	MP0003045_fibrosis	1.09090988
58	MP0008775_abnormal_heart_ventricle	1.07483429
59	MP0005174_abnormal_tail_pigmentation	1.06579483
60	MP0001501_abnormal_sleep_pattern	1.06473998
61	MP0002837_dystrophic_cardiac_calcinosis	1.03892604
62	MP0003315_abnormal_perineum_morphology	1.03853208
63	MP0003937_abnormal_limbs/digits/tail_de	0.98577902
64	MP0005646_abnormal_pituitary_gland	0.98297386
65	MP0001905_abnormal_dopamine_level	0.97978187
66	MP0002733_abnormal_thermal_nociception	0.94993553
67	MP0003718_maternal_effect	0.94787863
68	MP0002064_seizures	0.92514166
69	MP0009333_abnormal_splenocyte_physiolog	0.92268152
70	MP0000647_abnormal_sebaceous_gland	0.88632046
71	MP0001502_abnormal_circadian_rhythm	0.88142682
72	MP0000470_abnormal_stomach_morphology	0.87489606
73	MP0009046_muscle_twitch	0.86912593
74	MP0002938_white_spotting	0.86668399
75	MP0005310_abnormal_salivary_gland	0.86560135
76	MP0001529_abnormal_vocalization	0.85490182
77	MP0004742_abnormal_vestibular_system	0.85229225
78	MP0003183_abnormal_peptide_metabolism	0.82900963
79	MP0008961_abnormal_basal_metabolism	0.82647676
80	MP0002272_abnormal_nervous_system	0.82598667
81	MP0001440_abnormal_grooming_behavior	0.82451117
82	MP0002098_abnormal_vibrissa_morphology	0.82132281
83	MP0005253_abnormal_eye_physiology	0.81201520
84	MP0001800_abnormal_humoral_immune	0.76937048
85	MP0006036_abnormal_mitochondrial_physio	0.76528528
86	MP0003936_abnormal_reproductive_system	0.76480685
87	MP0004145_abnormal_muscle_electrophysio	0.75884500
88	MP0005448_abnormal_energy_balance	0.75853759
89	MP0001663_abnormal_digestive_system	0.74376315
90	MP0000371_diluted_coat_color	0.74055919
91	MP0002075_abnormal_coat/hair_pigmentati	0.72279753
92	MP0003137_abnormal_impulse_conducting	0.71585394
93	MP0002638_abnormal_pupillary_reflex	0.70862605
94	MP0003786_premature_aging	0.69837555
95	MP0002693_abnormal_pancreas_physiology	0.68206618
96	MP0002160_abnormal_reproductive_system	0.67801918
97	MP0005408_hypopigmentation	0.67550981
98	MP0001666_abnormal_nutrient_absorption	0.66579037
99	MP0002928_abnormal_bile_duct	0.66377508
100	MP0000703_abnormal_thymus_morphology	0.65961461

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Oligodactyly (hands) (HP:0001180)	4.07734487
2	Hypoproteinemia (HP:0003075)	3.78438015
3	Pancreatic cysts (HP:0001737)	3.61414539
4	Thyroiditis (HP:0100646)	3.45790960
5	Progressive inability to walk (HP:0002505)	3.30885962
6	Acute necrotizing encephalopathy (HP:0006965)	3.30224520
7	Volvulus (HP:0002580)	3.29183933
8	Methylmalonic acidemia (HP:0002912)	3.22389516
9	Neonatal respiratory distress (HP:0002643)	3.20719261
10	B lymphocytopenia (HP:0010976)	3.12725534
11	Congenital, generalized hypertrichosis (HP:0004540)	3.04603528
12	Abnormality of the renal cortex (HP:0011035)	2.97813685
13	Progressive macrocephaly (HP:0004481)	2.96578017
14	Febrile seizures (HP:0002373)	2.92825473
15	Large for gestational age (HP:0001520)	2.85036912
16	Abnormal mitochondria in muscle tissue (HP:0008316)	2.83835733
17	Oligodactyly (HP:0012165)	2.79009267
18	Increased CSF lactate (HP:0002490)	2.76567000
19	Fatigue (HP:0012378)	2.74505506
20	Methylmalonic aciduria (HP:0012120)	2.69675840
21	Acute encephalopathy (HP:0006846)	2.69494071
22	Mitochondrial inheritance (HP:0001427)	2.67161170
23	Abnormality of B cell number (HP:0010975)	2.65852329
24	Neoplasm of the adrenal cortex (HP:0100641)	2.56604863
25	Choroideremia (HP:0001139)	2.55328561
26	Abnormality of macular pigmentation (HP:0008002)	2.51817985
27	Hyperalaninemia (HP:0003348)	2.51633685
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.51633685
29	Abnormality of alanine metabolism (HP:0010916)	2.51633685
30	Increased serum pyruvate (HP:0003542)	2.51619485
31	Increased serum lactate (HP:0002151)	2.50494211
32	Inability to walk (HP:0002540)	2.46203117
33	Abnormality of glycolysis (HP:0004366)	2.43837377
34	Hypoplasia of the thymus (HP:0000778)	2.40994488
35	Hepatocellular necrosis (HP:0001404)	2.40681251
36	Abnormality of the pons (HP:0007361)	2.38724429
37	Congenital sensorineural hearing impairment (HP:0008527)	2.28212515
38	Rough bone trabeculation (HP:0100670)	2.27562729
39	Asplenia (HP:0001746)	2.26900741
40	Severe combined immunodeficiency (HP:0004430)	2.26599165
41	Panhypogammaglobulinemia (HP:0003139)	2.24255252
42	Hepatic necrosis (HP:0002605)	2.22463547
43	Congenital stationary night blindness (HP:0007642)	2.21185937
44	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.20964771
45	Abnormality of midbrain morphology (HP:0002418)	2.20959991
46	Molar tooth sign on MRI (HP:0002419)	2.20959991
47	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.16167586
48	Sensory axonal neuropathy (HP:0003390)	2.15716155
49	Pendular nystagmus (HP:0012043)	2.12817539
50	Testicular atrophy (HP:0000029)	2.11412628
51	Hypoplastic labia majora (HP:0000059)	2.08185976
52	Stenosis of the external auditory canal (HP:0000402)	2.06143477
53	Poor speech (HP:0002465)	2.03462166
54	Hypoplasia of the pons (HP:0012110)	2.03062464
55	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.98994205
56	Stomatitis (HP:0010280)	1.96061082
57	Genetic anticipation (HP:0003743)	1.95660273
58	Confusion (HP:0001289)	1.94873839
59	Cerebral edema (HP:0002181)	1.92985970
60	Lactic acidosis (HP:0003128)	1.92822212
61	Brittle hair (HP:0002299)	1.90670661
62	True hermaphroditism (HP:0010459)	1.90416923
63	Adrenal hypoplasia (HP:0000835)	1.89950137
64	Ileus (HP:0002595)	1.89920091
65	IgG deficiency (HP:0004315)	1.89846150
66	Abnormality of the ileum (HP:0001549)	1.88640742
67	Meckel diverticulum (HP:0002245)	1.88288160
68	Metaphyseal dysplasia (HP:0100255)	1.86504933
69	Hypoplastic female external genitalia (HP:0012815)	1.86273976
70	Abnormality of the renal medulla (HP:0100957)	1.85334488
71	Abnormality of the labia majora (HP:0012881)	1.83706868
72	Combined immunodeficiency (HP:0005387)	1.83676048
73	Labial hypoplasia (HP:0000066)	1.82852461
74	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.78868070
75	Hypoplasia of the fovea (HP:0007750)	1.78868070
76	Facial diplegia (HP:0001349)	1.78206113
77	Increased corneal curvature (HP:0100692)	1.78097433
78	Keratoconus (HP:0000563)	1.78097433
79	Furrowed tongue (HP:0000221)	1.76658372
80	Supernumerary bones of the axial skeleton (HP:0009144)	1.76267410
81	Autoimmune hemolytic anemia (HP:0001890)	1.75365751
82	Absent thumb (HP:0009777)	1.74451331
83	Neuroendocrine neoplasm (HP:0100634)	1.73975831
84	Lissencephaly (HP:0001339)	1.73374854
85	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.71107118
86	Pancreatic fibrosis (HP:0100732)	1.70828381
87	Papilledema (HP:0001085)	1.70384806
88	Conjunctival hamartoma (HP:0100780)	1.70177750
89	Renal cortical cysts (HP:0000803)	1.69609467
90	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.69280508
91	Sclerocornea (HP:0000647)	1.69034022
92	Progressive microcephaly (HP:0000253)	1.68987588
93	Blepharitis (HP:0000498)	1.67862414
94	Abnormality of vitamin B metabolism (HP:0004340)	1.66579454
95	Duodenal stenosis (HP:0100867)	1.65010756
96	Small intestinal stenosis (HP:0012848)	1.65010756
97	Erythroderma (HP:0001019)	1.63629992
98	Optic disc pallor (HP:0000543)	1.63407367
99	CNS demyelination (HP:0007305)	1.62229456
100	Abnormality of the nasal septum (HP:0000419)	1.62128734

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	5.12236388
2	FRK	3.97556057
3	TSSK6	3.24057992
4	VRK2	2.90758812
5	NEK1	2.80587975
6	SRPK1	2.66982982
7	TXK	2.46885301
8	TLK1	2.40225574
9	TRIM28	2.31910496
10	EIF2AK3	2.12580104
11	ZAK	2.08675122
12	STK39	2.01560353
13	WNK4	1.97110207
14	TAF1	1.92680454
15	PIK3CG	1.84129780
16	BUB1	1.77149314
17	GRK1	1.75538290
18	PHKG1	1.71824418
19	PHKG2	1.71824418
20	PLK3	1.65093846
21	BMPR1B	1.63082521
22	TESK1	1.62371198
23	PBK	1.58049524
24	CSNK1A1L	1.53185087
25	VRK1	1.49898434
26	MAP3K12	1.44486455
27	MAP4K2	1.43031983
28	NUAK1	1.42855882
29	INSRR	1.40898786
30	MAP2K6	1.36930315
31	MAPKAPK3	1.35700445
32	CSNK1G2	1.34825816
33	OXSR1	1.34682925
34	CSNK1G3	1.31911376
35	DYRK3	1.30313979
36	TNIK	1.24455961
37	ADRBK2	1.24055663
38	MKNK2	1.21926986
39	CSNK1G1	1.17796071
40	PASK	1.16281007
41	TAOK3	1.15832102
42	BCKDK	1.13425780
43	MAPKAPK5	1.12977472
44	BCR	1.02524398
45	LIMK1	0.98396151
46	SIK2	0.90982554
47	TGFBR1	0.83982331
48	PLK2	0.78939499
49	STK10	0.75784591
50	PLK1	0.73786669
51	TEC	0.70548434
52	EIF2AK2	0.66504972
53	DAPK1	0.65866002
54	TYRO3	0.62537651
55	GRK6	0.61778374
56	MAP3K11	0.59930262
57	STK24	0.58718326
58	PRKCE	0.58178572
59	CHEK2	0.58031367
60	TAOK1	0.57864944
61	LMTK2	0.57529588
62	MAPK13	0.56963277
63	MAP3K4	0.55537260
64	TAOK2	0.54030219
65	PLK4	0.53211805
66	CAMKK2	0.52497023
67	WNK1	0.51593866
68	EIF2AK1	0.50807576
69	CASK	0.50337636
70	MAP2K7	0.50236697
71	MUSK	0.50030102
72	PDK2	0.49557631
73	PINK1	0.45842030
74	MKNK1	0.44402046
75	MINK1	0.43587407
76	DAPK2	0.42999627
77	ADRBK1	0.42162394
78	PRKCG	0.41832250
79	WEE1	0.38847455
80	NEK2	0.38320761
81	GRK5	0.37966293
82	STK38L	0.37286113
83	DYRK2	0.37175839
84	IKBKB	0.36788719
85	CSNK2A1	0.36037331
86	ATR	0.35319572
87	RPS6KA5	0.33605479
88	CSNK1A1	0.32380043
89	SIK3	0.32359292
90	CAMK2A	0.32191483
91	EPHB2	0.31832277
92	MAP3K3	0.31723279
93	AURKB	0.31711377
94	CSNK1D	0.31032360
95	BRD4	0.30749305
96	ACVR1B	0.30713430
97	PRKCQ	0.28198545
98	MST1R	0.27869556
99	MOS	0.27373033
100	ATM	0.26557382

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.72545084
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.93402452
3	RNA polymerase_Homo sapiens_hsa03020	3.04019322
4	Basal transcription factors_Homo sapiens_hsa03022	2.89125199
5	Homologous recombination_Homo sapiens_hsa03440	2.59726092
6	Protein export_Homo sapiens_hsa03060	2.28327194
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.07285556
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.05407429
9	Non-homologous end-joining_Homo sapiens_hsa03450	1.95126461
10	Mismatch repair_Homo sapiens_hsa03430	1.94838304
11	One carbon pool by folate_Homo sapiens_hsa00670	1.91365440
12	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.90221599
13	RNA degradation_Homo sapiens_hsa03018	1.84482328
14	DNA replication_Homo sapiens_hsa03030	1.70356498
15	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.65371493
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.62768756
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.55458338
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.50350734
19	Parkinsons disease_Homo sapiens_hsa05012	1.48126644
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.47547234
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.46028869
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.44927977
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.44333377
24	Asthma_Homo sapiens_hsa05310	1.41997800
25	RNA transport_Homo sapiens_hsa03013	1.38352086
26	Sulfur metabolism_Homo sapiens_hsa00920	1.33703431
27	Allograft rejection_Homo sapiens_hsa05330	1.32789490
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.31050778
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.30967466
30	Primary immunodeficiency_Homo sapiens_hsa05340	1.29157756
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.26530277
32	Circadian rhythm_Homo sapiens_hsa04710	1.26110016
33	Spliceosome_Homo sapiens_hsa03040	1.25668353
34	Ribosome_Homo sapiens_hsa03010	1.24007449
35	Huntingtons disease_Homo sapiens_hsa05016	1.23324657
36	Phototransduction_Homo sapiens_hsa04744	1.19446775
37	Alzheimers disease_Homo sapiens_hsa05010	1.17247845
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.08651258
39	Propanoate metabolism_Homo sapiens_hsa00640	1.05603408
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05390108
41	Base excision repair_Homo sapiens_hsa03410	1.04300008
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03726866
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.02809055
44	Purine metabolism_Homo sapiens_hsa00230	0.99471603
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.95133835
46	Antigen processing and presentation_Homo sapiens_hsa04612	0.94695027
47	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.93756099
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92229602
49	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.90865681
50	Nicotine addiction_Homo sapiens_hsa05033	0.90770329
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90736938
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.86420367
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85133652
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83794010
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83496816
56	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.82436201
57	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.81638091
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.79294246
59	Peroxisome_Homo sapiens_hsa04146	0.79134503
60	Caffeine metabolism_Homo sapiens_hsa00232	0.76496952
61	Type I diabetes mellitus_Homo sapiens_hsa04940	0.75781209
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.72008162
63	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.71946400
64	Linoleic acid metabolism_Homo sapiens_hsa00591	0.69070882
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.67939839
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66405533
67	Glutathione metabolism_Homo sapiens_hsa00480	0.65927659
68	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.63910414
69	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63414340
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.62730614
71	Olfactory transduction_Homo sapiens_hsa04740	0.61899092
72	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.60643305
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.59462254
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59175266
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.56984360
76	Rheumatoid arthritis_Homo sapiens_hsa05323	0.56214699
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55315476
78	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.54318548
79	Folate biosynthesis_Homo sapiens_hsa00790	0.53463793
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.51765147
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.51516732
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.51029731
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50165381
84	Fatty acid elongation_Homo sapiens_hsa00062	0.49104089
85	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.48883145
86	Metabolic pathways_Homo sapiens_hsa01100	0.47086742
87	Morphine addiction_Homo sapiens_hsa05032	0.46968386
88	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46286989
89	Salivary secretion_Homo sapiens_hsa04970	0.44956542
90	Regulation of autophagy_Homo sapiens_hsa04140	0.43176015
91	Measles_Homo sapiens_hsa05162	0.41598897
92	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41529893
93	Vibrio cholerae infection_Homo sapiens_hsa05110	0.36473899
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.35036649
95	Legionellosis_Homo sapiens_hsa05134	0.34453296
96	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.34452048
97	p53 signaling pathway_Homo sapiens_hsa04115	0.33829312
98	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.33377809
99	Butanoate metabolism_Homo sapiens_hsa00650	0.33348509
100	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33223372

HSPA8P14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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