ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of systemic arterial blood pressure (GO:0003084)	6.81899137
2	regulation of urine volume (GO:0035809)	6.40612627
3	phenol-containing compound catabolic process (GO:0019336)	5.03827092
4	regulation of meiosis I (GO:0060631)	4.82226985
5	cAMP catabolic process (GO:0006198)	4.65957579
6	regulation of renal sodium excretion (GO:0035813)	4.61293024
7	activation of adenylate cyclase activity (GO:0007190)	4.42940057
8	carnitine shuttle (GO:0006853)	4.36222155
9	endocardial cushion morphogenesis (GO:0003203)	4.35752590
10	cyclic nucleotide catabolic process (GO:0009214)	4.28089201
11	regulation of somitogenesis (GO:0014807)	4.23676906
12	regulation of excretion (GO:0044062)	4.19738622
13	negative regulation of vascular permeability (GO:0043116)	4.13159081
14	regulation of centriole replication (GO:0046599)	4.12938480
15	telencephalon development (GO:0021537)	4.12302224
16	positive regulation of adenylate cyclase activity (GO:0045762)	4.10019111
17	cell migration in hindbrain (GO:0021535)	3.99805651
18	carnitine transport (GO:0015879)	3.96418217
19	amino-acid betaine transport (GO:0015838)	3.96418217
20	fatty acid transmembrane transport (GO:1902001)	3.94127446
21	reciprocal meiotic recombination (GO:0007131)	3.80197438
22	reciprocal DNA recombination (GO:0035825)	3.80197438
23	carnitine transmembrane transport (GO:1902603)	3.73105849
24	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.67300331
25	protein K11-linked deubiquitination (GO:0035871)	3.56117800
26	response to pheromone (GO:0019236)	3.53369390
27	regulation of skeletal muscle contraction (GO:0014819)	3.40442628
28	ovulation from ovarian follicle (GO:0001542)	3.35564577
29	retinal cone cell development (GO:0046549)	3.30029581
30	positive regulation of cyclase activity (GO:0031281)	3.27781338
31	negative regulation of astrocyte differentiation (GO:0048712)	3.25419341
32	negative regulation of meiosis (GO:0045835)	3.25116661
33	atrioventricular valve morphogenesis (GO:0003181)	3.22012562
34	high-density lipoprotein particle remodeling (GO:0034375)	3.19347797
35	positive regulation of lyase activity (GO:0051349)	3.18644439
36	mesenchyme morphogenesis (GO:0072132)	3.14486587
37	meiotic chromosome segregation (GO:0045132)	3.09170667
38	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.08705100
39	cAMP metabolic process (GO:0046058)	3.06869201
40	cAMP-mediated signaling (GO:0019933)	3.02951490
41	cerebral cortex radially oriented cell migration (GO:0021799)	2.96890381
42	snRNA transcription (GO:0009301)	2.96501300
43	triglyceride homeostasis (GO:0070328)	2.96417693
44	acylglycerol homeostasis (GO:0055090)	2.96417693
45	prostate gland growth (GO:0060736)	2.94953710
46	cell wall macromolecule catabolic process (GO:0016998)	2.94766914
47	positive regulation of vascular permeability (GO:0043117)	2.93311400
48	regulation of cilium movement (GO:0003352)	2.92247173
49	kinetochore assembly (GO:0051382)	2.91955943
50	protein-cofactor linkage (GO:0018065)	2.91817053
51	viral mRNA export from host cell nucleus (GO:0046784)	2.88616177
52	mitochondrion distribution (GO:0048311)	2.88094675
53	DNA integration (GO:0015074)	2.86708626
54	regulation of adenylate cyclase activity (GO:0045761)	2.84394444
55	replicative senescence (GO:0090399)	2.83145393
56	DNA double-strand break processing (GO:0000729)	2.81758623
57	detection of light stimulus involved in visual perception (GO:0050908)	2.81565158
58	detection of light stimulus involved in sensory perception (GO:0050962)	2.81565158
59	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.80362621
60	regulation of collateral sprouting (GO:0048670)	2.79809760
61	coronary vasculature morphogenesis (GO:0060977)	2.78363914
62	negative regulation of activin receptor signaling pathway (GO:0032926)	2.76967751
63	thyroid hormone generation (GO:0006590)	2.76221829
64	nonmotile primary cilium assembly (GO:0035058)	2.74677357
65	negative regulation of systemic arterial blood pressure (GO:0003085)	2.73447588
66	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.71361752
67	cGMP-mediated signaling (GO:0019934)	2.70823012
68	negative regulation of cAMP-mediated signaling (GO:0043951)	2.70014386
69	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.69049335
70	DNA demethylation (GO:0080111)	2.68495613
71	SMAD protein signal transduction (GO:0060395)	2.68379501
72	regulation of gamma-delta T cell differentiation (GO:0045586)	2.67920951
73	regulation of dendritic cell antigen processing and presentation (GO:0002604)	2.65113093
74	regulation of sarcomere organization (GO:0060297)	2.64946132
75	monoubiquitinated protein deubiquitination (GO:0035520)	2.64810805
76	regulation of meiosis (GO:0040020)	2.64456091
77	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.64221947
78	kinetochore organization (GO:0051383)	2.61065956
79	protein K63-linked deubiquitination (GO:0070536)	2.60694331
80	quaternary ammonium group transport (GO:0015697)	2.60204248
81	positive regulation of cAMP biosynthetic process (GO:0030819)	2.59463966
82	oxidative demethylation (GO:0070989)	2.58400303
83	L-fucose metabolic process (GO:0042354)	2.54731121
84	L-fucose catabolic process (GO:0042355)	2.54731121
85	fucose catabolic process (GO:0019317)	2.54731121
86	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	2.52447048
87	reverse cholesterol transport (GO:0043691)	2.50787280
88	replication fork processing (GO:0031297)	2.50235544
89	spindle assembly involved in mitosis (GO:0090307)	2.49805123
90	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.47653542
91	positive regulation of blood pressure (GO:0045777)	2.47115591
92	cell wall macromolecule metabolic process (GO:0044036)	2.46801198
93	lymph node development (GO:0048535)	2.46789879
94	adrenergic receptor signaling pathway (GO:0071875)	2.46277892
95	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.45827615
96	mesenchymal cell development (GO:0014031)	2.44123983
97	negative regulation of JAK-STAT cascade (GO:0046426)	2.43413232
98	regulation of cyclase activity (GO:0031279)	2.43114645
99	piRNA metabolic process (GO:0034587)	2.43113722
100	interferon-gamma production (GO:0032609)	10.4494639

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.66353407
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.73370054
3	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.28844645
4	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.13321641
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00659713
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.85732239
7	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.61851815
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.53900883
9	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.49447655
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.39178995
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.36307405
12	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.26264623
13	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.19513334
14	TP53_16413492_ChIP-PET_HCT116_Human	2.12028703
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.11444968
16	EWS_26573619_Chip-Seq_HEK293_Human	2.09673413
17	AR_21572438_ChIP-Seq_LNCaP_Human	1.96317775
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.94987336
19	VDR_22108803_ChIP-Seq_LS180_Human	1.94446981
20	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.90148821
21	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.87482135
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.85468221
23	GATA1_22025678_ChIP-Seq_K562_Human	1.83337422
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.80953137
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.75364497
26	P300_19829295_ChIP-Seq_ESCs_Human	1.74751287
27	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.74408580
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.69549922
29	STAT3_23295773_ChIP-Seq_U87_Human	1.69272439
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.67778004
31	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.66138484
32	TCF4_23295773_ChIP-Seq_U87_Human	1.59086017
33	FUS_26573619_Chip-Seq_HEK293_Human	1.58011279
34	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.56970889
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.56725612
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.53920969
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53920969
38	TCF4_22108803_ChIP-Seq_LS180_Human	1.49920961
39	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48744105
40	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48332612
41	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.47877419
42	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.46125583
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.42645034
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41623925
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39808164
46	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37698472
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.37198401
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.36410460
49	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.35319659
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34784855
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33710182
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33417865
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29851879
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.29485371
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29427062
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28652606
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24404961
58	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.23108487
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19562403
60	RXR_22108803_ChIP-Seq_LS180_Human	1.18801130
61	AR_25329375_ChIP-Seq_VCAP_Human	1.18452310
62	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17626936
63	KDM2B_26808549_Chip-Seq_REH_Human	1.16579510
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12741400
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10956377
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10079492
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.10079492
68	TP53_18474530_ChIP-ChIP_U2OS_Human	1.09361536
69	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08943519
70	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.08797696
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06484050
72	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.06358820
73	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.05253727
74	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05206435
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03416935
76	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02392441
77	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02012371
78	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.01839311
79	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01285378
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99751109
81	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.99146363
82	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.98205793
83	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98032769
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97853537
85	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.94819815
86	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.94680380
87	CJUN_26792858_Chip-Seq_BT549_Human	0.94338074
88	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.93698787
89	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93640391
90	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.90967316
91	CDX2_22108803_ChIP-Seq_LS180_Human	0.90798842
92	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.90659319
93	TP53_22573176_ChIP-Seq_HFKS_Human	0.90525828
94	P53_22387025_ChIP-Seq_ESCs_Mouse	0.90087944
95	RUNX_20019798_ChIP-Seq_JUKART_Human	0.88914572
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.88705389
97	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.88543549
98	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.87485300
99	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.87267078
100	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.87064673

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010368_abnormal_lymphatic_system	3.05444814
2	MP0003950_abnormal_plasma_membrane	3.01383563
3	MP0002163_abnormal_gland_morphology	2.86053485
4	MP0009697_abnormal_copulation	2.83048920
5	MP0000569_abnormal_digit_pigmentation	2.78861213
6	MP0001986_abnormal_taste_sensitivity	2.78576726
7	MP0001661_extended_life_span	2.71539583
8	MP0004215_abnormal_myocardial_fiber	2.69200860
9	MP0008877_abnormal_DNA_methylation	2.46191825
10	MP0000751_myopathy	2.41157742
11	MP0005174_abnormal_tail_pigmentation	2.40650649
12	MP0003868_abnormal_feces_composition	2.27816479
13	MP0000372_irregular_coat_pigmentation	2.13218855
14	MP0003646_muscle_fatigue	2.05050573
15	MP0000427_abnormal_hair_cycle	2.02885938
16	MP0002638_abnormal_pupillary_reflex	2.02128315
17	MP0003567_abnormal_fetal_cardiomyocyte	2.02024716
18	MP0001879_abnormal_lymphatic_vessel	2.00629679
19	MP0003252_abnormal_bile_duct	1.94304366
20	MP0000383_abnormal_hair_follicle	1.94028661
21	MP0005551_abnormal_eye_electrophysiolog	1.93425281
22	MP0005084_abnormal_gallbladder_morpholo	1.90570552
23	MP0005171_absent_coat_pigmentation	1.89704705
24	MP0009384_cardiac_valve_regurgitation	1.85807266
25	MP0010329_abnormal_lipoprotein_level	1.83261900
26	MP0003136_yellow_coat_color	1.82051802
27	MP0003195_calcinosis	1.72892648
28	MP0004043_abnormal_pH_regulation	1.66361993
29	MP0003693_abnormal_embryo_hatching	1.61698741
30	MP0002928_abnormal_bile_duct	1.58073451
31	MP0005365_abnormal_bile_salt	1.51522209
32	MP0001968_abnormal_touch/_nociception	1.42323986
33	MP0004381_abnormal_hair_follicle	1.40989372
34	MP0001756_abnormal_urination	1.38845223
35	MP0009840_abnormal_foam_cell	1.30177557
36	MP0000516_abnormal_urinary_system	1.30135330
37	MP0005367_renal/urinary_system_phenotyp	1.30135330
38	MP0006054_spinal_hemorrhage	1.28202365
39	MP0002138_abnormal_hepatobiliary_system	1.26277425
40	MP0002736_abnormal_nociception_after	1.26175506
41	MP0010094_abnormal_chromosome_stability	1.24344303
42	MP0003656_abnormal_erythrocyte_physiolo	1.23892744
43	MP0010678_abnormal_skin_adnexa	1.21788565
44	MP0002210_abnormal_sex_determination	1.19803049
45	MP0003698_abnormal_male_reproductive	1.19772584
46	MP0002160_abnormal_reproductive_system	1.19072827
47	MP0005379_endocrine/exocrine_gland_phen	1.18949993
48	MP0002396_abnormal_hematopoietic_system	1.16562148
49	MP0005409_darkened_coat_color	1.13147481
50	MP0004133_heterotaxia	1.12926124
51	MP0001929_abnormal_gametogenesis	1.11550196
52	MP0003943_abnormal_hepatobiliary_system	1.08852643
53	MP0003119_abnormal_digestive_system	1.08580894
54	MP0001765_abnormal_ion_homeostasis	1.08375731
55	MP0005164_abnormal_response_to	1.07608721
56	MP0004085_abnormal_heartbeat	1.06093127
57	MP0004883_abnormal_blood_vessel	1.04049828
58	MP0005636_abnormal_mineral_homeostasis	1.03201018
59	MP0000653_abnormal_sex_gland	1.01951670
60	MP0005410_abnormal_fertilization	1.01554310
61	MP0000631_abnormal_neuroendocrine_gland	1.01162267
62	MP0003283_abnormal_digestive_organ	1.00840049
63	MP0005167_abnormal_blood-brain_barrier	0.99248044
64	MP0005310_abnormal_salivary_gland	0.98440345
65	MP0008872_abnormal_physiological_respon	0.97360962
66	MP0005389_reproductive_system_phenotype	0.97134064
67	MP0002837_dystrophic_cardiac_calcinosis	0.96605620
68	MP0005253_abnormal_eye_physiology	0.95604895
69	MP0001299_abnormal_eye_distance/	0.94814845
70	MP0002106_abnormal_muscle_physiology	0.94711893
71	MP0001119_abnormal_female_reproductive	0.94383968
72	MP0003137_abnormal_impulse_conducting	0.90579771
73	MP0008058_abnormal_DNA_repair	0.90568820
74	MP0001145_abnormal_male_reproductive	0.90461869
75	MP0003937_abnormal_limbs/digits/tail_de	0.88745436
76	MP0005646_abnormal_pituitary_gland	0.86816113
77	MP0002090_abnormal_vision	0.85949929
78	MP0003111_abnormal_nucleus_morphology	0.85272551
79	MP0008775_abnormal_heart_ventricle	0.84620456
80	MP0004145_abnormal_muscle_electrophysio	0.83808505
81	MP0006138_congestive_heart_failure	0.83043722
82	MP0002269_muscular_atrophy	0.82448285
83	MP0002127_abnormal_cardiovascular_syste	0.82065505
84	MP0005330_cardiomyopathy	0.81355726
85	MP0000015_abnormal_ear_pigmentation	0.79365510
86	MP0008770_decreased_survivor_rate	0.78830146
87	MP0006072_abnormal_retinal_apoptosis	0.78281037
88	MP0001984_abnormal_olfaction	0.77550000
89	MP0002332_abnormal_exercise_endurance	0.75597567
90	MP0004147_increased_porphyrin_level	0.74778341
91	MP0003880_abnormal_central_pattern	0.74445321
92	MP0002735_abnormal_chemical_nociception	0.74171883
93	MP0001293_anophthalmia	0.72757982
94	MP0003936_abnormal_reproductive_system	0.72281032
95	MP0001764_abnormal_homeostasis	0.71327352
96	MP0003221_abnormal_cardiomyocyte_apopto	0.70859211
97	MP0002938_white_spotting	0.70646960
98	MP0010307_abnormal_tumor_latency	0.69371271
99	MP0005376_homeostasis/metabolism_phenot	0.67144029
100	MP0000371_diluted_coat_color	0.66881895

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal drinking behavior (HP:0030082)	6.25114952
2	Polydipsia (HP:0001959)	6.25114952
3	Abnormality of renin-angiotensin system (HP:0000847)	5.45207906
4	Polyuria (HP:0000103)	5.08820609
5	Hyponatremia (HP:0002902)	4.69207390
6	Amyotrophic lateral sclerosis (HP:0007354)	4.54823267
7	Abnormality of the lower motor neuron (HP:0002366)	4.54200344
8	Chronic hepatic failure (HP:0100626)	4.27627683
9	Abnormal urine output (HP:0012590)	4.20806311
10	Abnormality of sodium homeostasis (HP:0010931)	3.91263529
11	Posterior subcapsular cataract (HP:0007787)	3.80776152
12	Abnormality of renal excretion (HP:0011036)	3.48840783
13	Renal cortical cysts (HP:0000803)	3.48802031
14	Subcapsular cataract (HP:0000523)	3.42483041
15	Tongue fasciculations (HP:0001308)	3.18952138
16	Neonatal onset (HP:0003623)	3.13075796
17	Fair hair (HP:0002286)	3.00160694
18	Abnormality of the renal cortex (HP:0011035)	2.87103292
19	Hypoplasia of the uterus (HP:0000013)	2.82316013
20	Muscle fibrillation (HP:0010546)	2.77253063
21	Tetraparesis (HP:0002273)	2.75012472
22	Molar tooth sign on MRI (HP:0002419)	2.43332806
23	Abnormality of midbrain morphology (HP:0002418)	2.43332806
24	Subacute progressive viral hepatitis (HP:0006572)	2.37958526
25	Overriding aorta (HP:0002623)	2.30236530
26	Cystic hygroma (HP:0000476)	2.29283251
27	Short chin (HP:0000331)	2.24956661
28	Dyskinesia (HP:0100660)	2.24064196
29	Hypomagnesemia (HP:0002917)	2.15045407
30	Hypoproteinemia (HP:0003075)	2.13077045
31	Abnormal biliary tract physiology (HP:0012439)	2.12543543
32	Bile duct proliferation (HP:0001408)	2.12543543
33	Hemiplegia (HP:0002301)	2.11261531
34	Generalized hypopigmentation of hair (HP:0011358)	2.09596456
35	Neonatal respiratory distress (HP:0002643)	2.08656766
36	Anteriorly placed anus (HP:0001545)	2.08321502
37	Areflexia of lower limbs (HP:0002522)	2.05713544
38	Hyperlipoproteinemia (HP:0010980)	2.03923545
39	Attenuation of retinal blood vessels (HP:0007843)	2.02086014
40	Decreased circulating renin level (HP:0003351)	10.4955864
41	Small hand (HP:0200055)	1.98601068
42	Progressive muscle weakness (HP:0003323)	1.97931116
43	Syncope (HP:0001279)	1.97388938
44	Type 2 muscle fiber atrophy (HP:0003554)	1.96838333
45	Nephronophthisis (HP:0000090)	1.93117531
46	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91196904
47	EMG: neuropathic changes (HP:0003445)	1.89926197
48	Abnormality of the pons (HP:0007361)	1.89511230
49	Mesangial abnormality (HP:0001966)	1.88116253
50	Abnormality of the renal medulla (HP:0100957)	1.87203882
51	Absent septum pellucidum (HP:0001331)	1.84748096
52	Hyperventilation (HP:0002883)	1.84010106
53	Hyperinsulinemic hypoglycemia (HP:0000825)	1.83063013
54	Rectal fistula (HP:0100590)	1.82857274
55	Rectovaginal fistula (HP:0000143)	1.82857274
56	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.82517213
57	Progressive inability to walk (HP:0002505)	1.82322980
58	Absent hand (HP:0004050)	1.77825389
59	Shawl scrotum (HP:0000049)	1.77662423
60	Pancreatic cysts (HP:0001737)	1.75448906
61	Duplicated collecting system (HP:0000081)	1.73354498
62	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.73233590
63	Median cleft lip (HP:0000161)	1.69355890
64	Intellectual disability, moderate (HP:0002342)	1.68519330
65	Hyporeflexia of lower limbs (HP:0002600)	1.67807679
66	Flat capital femoral epiphysis (HP:0003370)	1.66126994
67	IgM deficiency (HP:0002850)	1.65734975
68	Postaxial foot polydactyly (HP:0001830)	1.63796666
69	Hypoglycemic coma (HP:0001325)	1.63771658
70	Lymphangioma (HP:0100764)	1.62921598
71	Atrial fibrillation (HP:0005110)	1.61678803
72	Hypobetalipoproteinemia (HP:0003563)	1.61442787
73	Pigmentary retinal degeneration (HP:0001146)	1.61073033
74	Ectopic anus (HP:0004397)	1.59712650
75	IgG deficiency (HP:0004315)	1.59116437
76	Congenital hepatic fibrosis (HP:0002612)	1.57034452
77	Biliary tract neoplasm (HP:0100574)	1.56240845
78	Intestinal fistula (HP:0100819)	1.55114453
79	Abnormal biliary tract morphology (HP:0012440)	1.54379885
80	Polar cataract (HP:0010696)	1.53267252
81	Ectopic kidney (HP:0000086)	1.52304417
82	Abnormality of the phalanges of the hallux (HP:0010057)	1.51937822
83	Bifid tongue (HP:0010297)	1.51139048
84	Abnormality of the renal collecting system (HP:0004742)	1.50351642
85	Cutaneous melanoma (HP:0012056)	1.50214794
86	Ketoacidosis (HP:0001993)	1.48937387
87	Sacral dimple (HP:0000960)	1.47558078
88	Irritability (HP:0000737)	1.47450170
89	Preaxial hand polydactyly (HP:0001177)	1.46474987
90	Abnormal number of erythroid precursors (HP:0012131)	1.45560349
91	Type II lissencephaly (HP:0007260)	1.45501389
92	Bony spicule pigmentary retinopathy (HP:0007737)	1.45233752
93	Inability to walk (HP:0002540)	1.45221181
94	Pancreatic fibrosis (HP:0100732)	1.45021617
95	Congenital stationary night blindness (HP:0007642)	1.44449630
96	Broad palm (HP:0001169)	1.44239354
97	Increased number of teeth (HP:0011069)	1.42457873
98	Tented upper lip vermilion (HP:0010804)	1.41963880
99	Abnormality of the septum pellucidum (HP:0007375)	1.41839556
100	Exotropia (HP:0000577)	1.41792369

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MUSK	5.31849435
2	TNIK	4.66613047
3	BLK	3.99814016
4	MAP4K2	3.05317763
5	PNCK	2.85810007
6	FRK	2.68784100
7	PRKD3	2.63225131
8	PLK4	2.59272590
9	TAOK3	2.33420743
10	TGFBR2	2.28877364
11	ZAK	2.06521523
12	NUAK1	1.96126789
13	MAP3K4	1.95311228
14	TXK	1.93786971
15	PDK2	1.92750229
16	NME1	1.81668841
17	AKT3	1.77530916
18	WNK4	1.76876506
19	MAPK13	1.72518944
20	EPHB2	1.65307730
21	PTK2B	1.61137134
22	MOS	1.58657566
23	EPHA4	1.56301599
24	RAF1	1.55121400
25	GRK7	1.40962519
26	LATS1	1.40028791
27	GRK5	1.11797597
28	PBK	1.08001343
29	CAMK1G	1.06120083
30	MAPKAPK3	1.05182832
31	STK39	1.04406652
32	CCNB1	0.99733624
33	BMPR2	0.95871127
34	PAK3	0.83269830
35	PRKCH	0.83040055
36	PRKD1	0.81790757
37	KSR2	0.81076193
38	PLK2	0.76017911
39	ADRBK2	0.74992118
40	ADRBK1	0.74092342
41	PDGFRB	0.73717942
42	MAP3K13	0.71577403
43	TRIM28	0.68129328
44	MYLK	0.67415530
45	MAPK15	0.67365914
46	FGFR2	0.66936202
47	LYN	0.65349265
48	MAPK7	0.64896409
49	MKNK2	0.64460107
50	PRKCE	0.63617689
51	STK3	0.63163953
52	OXSR1	0.60330827
53	MARK3	0.60112873
54	ROCK1	0.59224762
55	EIF2AK2	0.58618992
56	CSK	0.56403448
57	DDR2	0.54040821
58	FGR	0.53871241
59	ATM	0.52932237
60	ATR	0.52284327
61	PRKD2	0.51916888
62	MAP3K2	0.51916746
63	DYRK3	0.50820501
64	KIT	0.50720018
65	MAP2K1	0.49204305
66	NEK6	0.47651596
67	OBSCN	0.46702333
68	TLK1	0.45980060
69	NTRK3	0.45411221
70	ABL1	0.44670720
71	ACVR1B	0.44602876
72	SYK	0.43618254
73	KSR1	0.42838052
74	PRKAA2	0.42235447
75	WEE1	0.40568886
76	PIK3CA	0.40374820
77	INSR	0.39178521
78	TNK2	0.39162215
79	PIK3CG	0.39136816
80	WNK3	0.38559970
81	PRKACA	0.37125287
82	SGK2	0.36754191
83	CSNK1D	0.36451842
84	STK10	0.35421445
85	ERBB2	0.34642780
86	CAMK2D	0.34554629
87	MARK1	0.33129885
88	PDK1	0.31848969
89	PAK6	0.31768240
90	MAP2K2	0.31038323
91	PASK	0.30840670
92	CDK5	0.30549927
93	BRD4	0.30290830
94	GRK1	0.29909615
95	DYRK1A	0.28526047
96	NTRK2	0.28168462
97	ERBB3	0.26316242
98	NLK	0.26216978
99	BMPR1B	0.26120896
100	ITK	0.26038411

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.29822608
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.12746324
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.74970547
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.46677815
5	Circadian rhythm_Homo sapiens_hsa04710	2.38571005
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.36555469
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.29275210
8	Propanoate metabolism_Homo sapiens_hsa00640	1.92942615
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.89910258
10	Phototransduction_Homo sapiens_hsa04744	1.86204653
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.85968465
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.81810762
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.76631652
14	Fatty acid metabolism_Homo sapiens_hsa01212	1.70384227
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.61002450
16	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.57211818
17	Sulfur relay system_Homo sapiens_hsa04122	1.56661461
18	Renin secretion_Homo sapiens_hsa04924	1.55775982
19	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.54644019
20	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.54249218
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.53408412
22	Fatty acid elongation_Homo sapiens_hsa00062	1.45351152
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.44994727
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.39140575
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38931423
26	RNA degradation_Homo sapiens_hsa03018	1.36589815
27	Butanoate metabolism_Homo sapiens_hsa00650	1.30562992
28	Morphine addiction_Homo sapiens_hsa05032	1.29249864
29	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.24793625
30	Caffeine metabolism_Homo sapiens_hsa00232	1.23447462
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.22678024
32	ABC transporters_Homo sapiens_hsa02010	1.22163697
33	Taste transduction_Homo sapiens_hsa04742	1.17480770
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.15136523
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.13007727
36	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.11734377
37	Fatty acid degradation_Homo sapiens_hsa00071	1.10687949
38	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.09977295
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.07550043
40	Calcium signaling pathway_Homo sapiens_hsa04020	1.05658873
41	Homologous recombination_Homo sapiens_hsa03440	1.04660526
42	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.03941583
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.03486336
44	Peroxisome_Homo sapiens_hsa04146	1.01987329
45	PPAR signaling pathway_Homo sapiens_hsa03320	1.01490195
46	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.01383481
47	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.99507588
48	Nicotine addiction_Homo sapiens_hsa05033	0.99358295
49	Purine metabolism_Homo sapiens_hsa00230	0.97842519
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.97077566
51	Mineral absorption_Homo sapiens_hsa04978	0.95961931
52	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.93458143
53	RNA polymerase_Homo sapiens_hsa03020	0.92900285
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.91877594
55	Lysine degradation_Homo sapiens_hsa00310	0.91269645
56	Non-homologous end-joining_Homo sapiens_hsa03450	0.90497962
57	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.89969455
58	Insulin secretion_Homo sapiens_hsa04911	0.88037034
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.87145123
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.86492097
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.84079181
62	cAMP signaling pathway_Homo sapiens_hsa04024	0.83759014
63	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.82411920
64	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.82268218
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81897314
66	Primary immunodeficiency_Homo sapiens_hsa05340	0.80943371
67	Selenocompound metabolism_Homo sapiens_hsa00450	0.80116326
68	Regulation of autophagy_Homo sapiens_hsa04140	0.79415603
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78560192
70	Arginine biosynthesis_Homo sapiens_hsa00220	0.70718699
71	ECM-receptor interaction_Homo sapiens_hsa04512	0.69974179
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.68696551
73	Complement and coagulation cascades_Homo sapiens_hsa04610	0.66645543
74	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.65869341
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.64135190
76	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62013135
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61842241
78	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.61260978
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61046943
80	Salivary secretion_Homo sapiens_hsa04970	0.57819070
81	Insulin resistance_Homo sapiens_hsa04931	0.57715404
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.57420154
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.54815868
84	Circadian entrainment_Homo sapiens_hsa04713	0.53784839
85	Melanogenesis_Homo sapiens_hsa04916	0.50889102
86	Gap junction_Homo sapiens_hsa04540	0.50446480
87	GABAergic synapse_Homo sapiens_hsa04727	0.49350130
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.44146750
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.42602640
90	Type II diabetes mellitus_Homo sapiens_hsa04930	0.41953155
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.40625993
92	Retinol metabolism_Homo sapiens_hsa00830	0.40480096
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.40020873
94	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.38916473
95	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.38744699
96	Serotonergic synapse_Homo sapiens_hsa04726	0.38482083
97	Cholinergic synapse_Homo sapiens_hsa04725	0.37281820
98	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.36761813
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.36757376
100	Focal adhesion_Homo sapiens_hsa04510	0.36336984

HSPA8P15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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