HSPA8P16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.40470638
2DNA deamination (GO:0045006)5.51747523
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.25606554
4transcription from mitochondrial promoter (GO:0006390)4.45513612
5rRNA modification (GO:0000154)4.40169354
6ATP synthesis coupled proton transport (GO:0015986)4.38983026
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38983026
8chaperone-mediated protein transport (GO:0072321)4.08881975
9regulation of cellular amino acid metabolic process (GO:0006521)3.98680154
10rRNA methylation (GO:0031167)3.97415987
11DNA double-strand break processing (GO:0000729)3.95408246
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.91237410
13water-soluble vitamin biosynthetic process (GO:0042364)3.88735440
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.86702453
15somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.74283567
16isotype switching (GO:0045190)3.74283567
17somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.74283567
18termination of RNA polymerase III transcription (GO:0006386)3.72438746
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.72438746
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.71596125
21protein deneddylation (GO:0000338)3.70358641
22cullin deneddylation (GO:0010388)3.70223007
23mitochondrial RNA metabolic process (GO:0000959)3.69662056
24regulation of isotype switching to IgG isotypes (GO:0048302)3.65762603
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.63108331
26respiratory chain complex IV assembly (GO:0008535)3.58076777
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.53241800
28pseudouridine synthesis (GO:0001522)3.53096310
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52482824
30regulation of immunoglobulin secretion (GO:0051023)3.52077520
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.51757836
32negative regulation of ligase activity (GO:0051352)3.51757836
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51729617
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.48458310
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.48458310
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.48458310
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.44081001
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.44081001
39protein complex biogenesis (GO:0070271)3.41325586
40maturation of 5.8S rRNA (GO:0000460)3.34330244
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32562110
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.31780744
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.31780744
44L-fucose metabolic process (GO:0042354)3.30121717
45L-fucose catabolic process (GO:0042355)3.30121717
46fucose catabolic process (GO:0019317)3.30121717
47mitochondrial respiratory chain complex assembly (GO:0033108)3.27486600
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.27192100
49regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.27019539
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.26558985
51protein-cofactor linkage (GO:0018065)3.24291193
52termination of RNA polymerase I transcription (GO:0006363)3.23026610
53cytidine metabolic process (GO:0046087)3.17704305
54cytidine catabolic process (GO:0006216)3.17704305
55cytidine deamination (GO:0009972)3.17704305
56cytochrome complex assembly (GO:0017004)3.16830051
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16590859
58mannosylation (GO:0097502)3.16498173
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.15484311
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.15484311
61transcription elongation from RNA polymerase I promoter (GO:0006362)3.15253240
62alpha-beta T cell differentiation involved in immune response (GO:0002293)3.14543610
63alpha-beta T cell activation involved in immune response (GO:0002287)3.14543610
64T cell differentiation involved in immune response (GO:0002292)3.14543610
65ribosome assembly (GO:0042255)3.12556212
66mitochondrial respiratory chain complex I assembly (GO:0032981)3.12104791
67NADH dehydrogenase complex assembly (GO:0010257)3.12104791
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12104791
69protein neddylation (GO:0045116)3.07289414
70positive regulation of ligase activity (GO:0051351)3.06148006
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01602476
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.00544828
73signal peptide processing (GO:0006465)2.99934463
74electron transport chain (GO:0022900)2.96748113
75respiratory electron transport chain (GO:0022904)2.96182408
76intracellular protein transmembrane import (GO:0044743)2.95832592
77positive regulation of chemokine biosynthetic process (GO:0045080)2.95306363
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92335653
79regulation of cellular amine metabolic process (GO:0033238)2.90493129
80regulation of chronic inflammatory response (GO:0002676)2.84728962
81kynurenine metabolic process (GO:0070189)2.82405349
82GTP biosynthetic process (GO:0006183)2.79574468
83chaperone mediated protein folding requiring cofactor (GO:0051085)2.79208873
84positive regulation of interleukin-1 beta secretion (GO:0050718)2.77909157
85tRNA processing (GO:0008033)2.76295416
86rRNA processing (GO:0006364)2.75876107
87regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.75679568
88DNA catabolic process, exonucleolytic (GO:0000738)2.75093523
89regulation of ubiquitin-protein transferase activity (GO:0051438)2.74233076
90rRNA metabolic process (GO:0016072)2.74196263
91behavioral response to nicotine (GO:0035095)2.73652345
92DNA damage response, detection of DNA damage (GO:0042769)2.73226845
93tRNA metabolic process (GO:0006399)2.73080581
94regulation of interleukin-12 biosynthetic process (GO:0045075)2.72885153
95positive regulation of cell cycle arrest (GO:0071158)2.71891144
96hydrogen ion transmembrane transport (GO:1902600)2.71683463
97transcription initiation from RNA polymerase I promoter (GO:0006361)2.69960870
98negative regulation of T cell differentiation in thymus (GO:0033085)2.68289479
99antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.67350424
100regulation of ligase activity (GO:0051340)2.67331107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.83932887
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.45687444
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.33940889
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.66748502
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11042721
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.00478380
7VDR_22108803_ChIP-Seq_LS180_Human2.98323405
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94044539
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.85942811
10ZNF274_21170338_ChIP-Seq_K562_Hela2.85701524
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.81024254
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64292838
13VDR_23849224_ChIP-Seq_CD4+_Human2.59535194
14ELK1_19687146_ChIP-ChIP_HELA_Human2.50341290
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43841553
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.43552917
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21834814
18FOXP3_21729870_ChIP-Seq_TREG_Human2.07432313
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02284079
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01435446
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94546764
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83643571
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.82246711
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80702660
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80472052
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78952404
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75301626
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.73587607
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.73278341
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73069206
31TP53_22573176_ChIP-Seq_HFKS_Human1.65648930
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64591818
33EWS_26573619_Chip-Seq_HEK293_Human1.61705411
34DCP1A_22483619_ChIP-Seq_HELA_Human1.58679447
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55328537
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53640146
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49300146
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46011241
39IRF1_19129219_ChIP-ChIP_H3396_Human1.43766269
40GATA1_22025678_ChIP-Seq_K562_Human1.42844268
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41310573
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39823637
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37637254
44MYC_18940864_ChIP-ChIP_HL60_Human1.37635647
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36221546
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34003687
47GABP_19822575_ChIP-Seq_HepG2_Human1.32797903
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30560814
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30234576
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29902687
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29534289
52TAF15_26573619_Chip-Seq_HEK293_Human1.27066004
53FUS_26573619_Chip-Seq_HEK293_Human1.25132446
54P300_19829295_ChIP-Seq_ESCs_Human1.24546813
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23216145
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22850163
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22318931
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.15906228
59GATA3_26560356_Chip-Seq_TH2_Human1.13349404
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10773668
61NANOG_19829295_ChIP-Seq_ESCs_Human1.07945312
62SOX2_19829295_ChIP-Seq_ESCs_Human1.07945312
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06185604
64ER_23166858_ChIP-Seq_MCF-7_Human1.04036327
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.03108592
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.02914503
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02914503
68BCAT_22108803_ChIP-Seq_LS180_Human1.02768137
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02258675
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.01451399
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.00427213
72TTF2_22483619_ChIP-Seq_HELA_Human0.99895390
73CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99050806
74LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98843211
75NCOR_22424771_ChIP-Seq_293T_Human0.97004989
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96812409
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95563542
78CBP_20019798_ChIP-Seq_JUKART_Human0.95563542
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94319592
80AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93996702
81IRF8_21731497_ChIP-ChIP_J774_Mouse0.92734283
82IGF1R_20145208_ChIP-Seq_DFB_Human0.92608199
83TCF4_22108803_ChIP-Seq_LS180_Human0.92533411
84FOXH1_21741376_ChIP-Seq_EPCs_Human0.90813622
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90375932
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.90325601
87E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89439777
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88215493
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.88186733
90HOXB7_26014856_ChIP-Seq_BT474_Human0.88024221
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87589617
92SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86843650
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86016119
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85797619
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.85717005
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83760531
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82759360
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82730711
99RBPJ_21746931_ChIP-Seq_IB4_Human0.82266348
100AR_20517297_ChIP-Seq_VCAP_Human0.82117410

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok3.68811068
2MP0001835_abnormal_antigen_presentation3.23924023
3MP0001873_stomach_inflammation3.12013953
4MP0000569_abnormal_digit_pigmentation3.00440183
5MP0005671_abnormal_response_to2.74085089
6MP0005360_urolithiasis2.73590737
7MP0001984_abnormal_olfaction2.62596541
8MP0002163_abnormal_gland_morphology2.47045947
9MP0006072_abnormal_retinal_apoptosis2.37836777
10MP0002837_dystrophic_cardiac_calcinosis2.35453680
11MP0002102_abnormal_ear_morphology2.19513283
12MP0003186_abnormal_redox_activity2.18837427
13MP0005379_endocrine/exocrine_gland_phen2.18404068
14MP0008872_abnormal_physiological_respon2.18308753
15MP0003806_abnormal_nucleotide_metabolis2.05096401
16MP0009333_abnormal_splenocyte_physiolog1.93324078
17MP0009785_altered_susceptibility_to1.87619294
18MP0005387_immune_system_phenotype1.87127811
19MP0001790_abnormal_immune_system1.87127811
20MP0001348_abnormal_lacrimal_gland1.86073796
21MP0004145_abnormal_muscle_electrophysio1.83164339
22MP0008877_abnormal_DNA_methylation1.78371062
23MP0001501_abnormal_sleep_pattern1.73082992
24MP0002148_abnormal_hypersensitivity_rea1.71826490
25MP0000372_irregular_coat_pigmentation1.70280408
26MP0002166_altered_tumor_susceptibility1.62468393
27MP0003718_maternal_effect1.58245928
28MP0005645_abnormal_hypothalamus_physiol1.56832420
29MP0003195_calcinosis1.55416579
30MP0002006_tumorigenesis1.51309333
31MP0008058_abnormal_DNA_repair1.50657776
32MP0000685_abnormal_immune_system1.49920495
33MP0002138_abnormal_hepatobiliary_system1.48608404
34MP0005085_abnormal_gallbladder_physiolo1.48366349
35MP0005551_abnormal_eye_electrophysiolog1.48262985
36MP0004742_abnormal_vestibular_system1.44114869
37MP0005084_abnormal_gallbladder_morpholo1.39789545
38MP0001800_abnormal_humoral_immune1.38052868
39MP0004142_abnormal_muscle_tone1.37221341
40MP0002272_abnormal_nervous_system1.37212966
41MP0001919_abnormal_reproductive_system1.35695303
42MP0001905_abnormal_dopamine_level1.34880944
43MP0001968_abnormal_touch/_nociception1.33930477
44MP0005408_hypopigmentation1.29880648
45MP0003646_muscle_fatigue1.29859037
46MP0003693_abnormal_embryo_hatching1.29537710
47MP0005389_reproductive_system_phenotype1.29510016
48MP0008007_abnormal_cellular_replicative1.25934737
49MP0003786_premature_aging1.25423441
50MP0004957_abnormal_blastocyst_morpholog1.22810987
51MP0003950_abnormal_plasma_membrane1.21384241
52MP0003252_abnormal_bile_duct1.19232069
53MP0005171_absent_coat_pigmentation1.18649943
54MP0002876_abnormal_thyroid_physiology1.18029080
55MP0004782_abnormal_surfactant_physiolog1.17051060
56MP0003763_abnormal_thymus_physiology1.16126408
57MP0006082_CNS_inflammation1.13259692
58MP0001440_abnormal_grooming_behavior1.11735211
59MP0000427_abnormal_hair_cycle1.11190342
60MP0009046_muscle_twitch1.10739519
61MP0009745_abnormal_behavioral_response1.10151017
62MP0000371_diluted_coat_color1.07671440
63MP0006036_abnormal_mitochondrial_physio1.07239985
64MP0009697_abnormal_copulation1.06672633
65MP0005253_abnormal_eye_physiology1.05387666
66MP0002277_abnormal_respiratory_mucosa1.04140661
67MP0005636_abnormal_mineral_homeostasis1.02628785
68MP0005000_abnormal_immune_tolerance1.01491290
69MP0002938_white_spotting1.00385378
70MP0001529_abnormal_vocalization1.00363264
71MP0003567_abnormal_fetal_cardiomyocyte0.99796254
72MP0010094_abnormal_chromosome_stability0.97408653
73MP0002160_abnormal_reproductive_system0.96135992
74MP0005332_abnormal_amino_acid0.94296602
75MP0001188_hyperpigmentation0.93920373
76MP0005310_abnormal_salivary_gland0.93069185
77MP0005075_abnormal_melanosome_morpholog0.91354310
78MP0005365_abnormal_bile_salt0.89459897
79MP0002095_abnormal_skin_pigmentation0.89077348
80MP0001502_abnormal_circadian_rhythm0.89009013
81MP0001881_abnormal_mammary_gland0.88356222
82MP0006035_abnormal_mitochondrial_morpho0.85766482
83MP0002723_abnormal_immune_serum0.85243997
84MP0000538_abnormal_urinary_bladder0.85048316
85MP0002452_abnormal_antigen_presenting0.82769508
86MP0004381_abnormal_hair_follicle0.82130975
87MP0001663_abnormal_digestive_system0.81689727
88MP0001485_abnormal_pinna_reflex0.79641025
89MP0004043_abnormal_pH_regulation0.78548039
90MP0010386_abnormal_urinary_bladder0.77705408
91MP0004215_abnormal_myocardial_fiber0.77247887
92MP0002736_abnormal_nociception_after0.77025508
93MP0006276_abnormal_autonomic_nervous0.76302179
94MP0002733_abnormal_thermal_nociception0.75613643
95MP0000647_abnormal_sebaceous_gland0.75610085
96MP0003866_abnormal_defecation0.74044889
97MP0002420_abnormal_adaptive_immunity0.71506108
98MP0005410_abnormal_fertilization0.71442620
99MP0005167_abnormal_blood-brain_barrier0.70610185
100MP0002210_abnormal_sex_determination0.70502203

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.44987373
2Acute encephalopathy (HP:0006846)4.04618447
3Increased CSF lactate (HP:0002490)3.93588638
4Stomatitis (HP:0010280)3.90240167
5Mitochondrial inheritance (HP:0001427)3.89646657
6Progressive macrocephaly (HP:0004481)3.88183704
7Abnormal mitochondria in muscle tissue (HP:0008316)3.75881471
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.62423230
9Abnormality of alanine metabolism (HP:0010916)3.62423230
10Hyperalaninemia (HP:0003348)3.62423230
11Lipid accumulation in hepatocytes (HP:0006561)3.57209946
12Increased hepatocellular lipid droplets (HP:0006565)3.26522166
13Hepatocellular necrosis (HP:0001404)3.23628646
14Type II lissencephaly (HP:0007260)3.23272365
15IgG deficiency (HP:0004315)3.20187842
16Increased serum lactate (HP:0002151)3.10612012
17Hepatic necrosis (HP:0002605)3.08604909
18Abnormality of the pons (HP:0007361)3.03619742
193-Methylglutaconic aciduria (HP:0003535)3.01200488
20Aplasia/hypoplasia of the uterus (HP:0008684)2.86977613
21Renal Fanconi syndrome (HP:0001994)2.85946139
22Pancreatic cysts (HP:0001737)2.79393558
23Cerebral edema (HP:0002181)2.76093771
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.64406747
25Abnormality of the labia minora (HP:0012880)2.63681795
26Hypomagnesemia (HP:0002917)2.63232253
27Hypoplasia of the pons (HP:0012110)2.62468186
28Abnormality of the anterior horn cell (HP:0006802)2.61895621
29Degeneration of anterior horn cells (HP:0002398)2.61895621
30Congenital, generalized hypertrichosis (HP:0004540)2.53466857
31Hypoproteinemia (HP:0003075)2.44452774
32Lactic acidosis (HP:0003128)2.44129758
33Optic disc pallor (HP:0000543)2.43651528
34Renal cortical cysts (HP:0000803)2.41531236
35Leukodystrophy (HP:0002415)2.38104585
36Hypothermia (HP:0002045)2.36630338
37Respiratory failure (HP:0002878)2.34202439
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33990082
39Abnormality of magnesium homeostasis (HP:0004921)2.30511572
40Type I transferrin isoform profile (HP:0003642)2.28102699
41Increased serum pyruvate (HP:0003542)2.27861641
42Cerebellar dysplasia (HP:0007033)2.23120901
43Abnormality of glycolysis (HP:0004366)2.22784636
44Congenital stationary night blindness (HP:0007642)2.20747834
45Increased IgM level (HP:0003496)2.20452113
46Large for gestational age (HP:0001520)2.16817801
47Aplastic anemia (HP:0001915)2.16162390
48Hypoplasia of the uterus (HP:0000013)2.15511072
49Lethargy (HP:0001254)2.14471547
50Molar tooth sign on MRI (HP:0002419)2.12943535
51Abnormality of midbrain morphology (HP:0002418)2.12943535
52Cleft eyelid (HP:0000625)2.11733561
53Exertional dyspnea (HP:0002875)2.09639257
54Fibular aplasia (HP:0002990)2.08995927
55Posterior subcapsular cataract (HP:0007787)2.08717844
56Spastic paraparesis (HP:0002313)2.02844697
57Pancreatic fibrosis (HP:0100732)2.02824394
58Exercise intolerance (HP:0003546)2.02288837
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.02112467
60Gaze-evoked nystagmus (HP:0000640)2.01129015
61Tongue fasciculations (HP:0001308)2.00219662
62Adactyly (HP:0009776)2.00149928
63Abnormality of the renal cortex (HP:0011035)1.99880253
64Increased intramyocellular lipid droplets (HP:0012240)1.99409268
65Opisthotonus (HP:0002179)1.98635257
66Abnormality of T cell physiology (HP:0011840)1.98230844
67True hermaphroditism (HP:0010459)1.97396821
68Generalized aminoaciduria (HP:0002909)1.97173867
69Parakeratosis (HP:0001036)1.96632854
70Severe muscular hypotonia (HP:0006829)1.96353340
71Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96301558
72Constricted visual fields (HP:0001133)1.96266962
73Type 2 muscle fiber atrophy (HP:0003554)1.95853924
74Chronic diarrhea (HP:0002028)1.95378798
75Megaloblastic anemia (HP:0001889)1.94304228
76IgA deficiency (HP:0002720)1.94030625
77Meckel diverticulum (HP:0002245)1.93610557
78Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.93313545
79Hypoalbuminemia (HP:0003073)1.91811974
80Abnormal albumin level (HP:0012116)1.91811974
81Nephronophthisis (HP:0000090)1.90281890
82Increased muscle lipid content (HP:0009058)1.90093571
83Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85761595
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85761595
85Abnormality of urine glucose concentration (HP:0011016)1.84070427
86Glycosuria (HP:0003076)1.84070427
87Abnormality of the ileum (HP:0001549)1.83517278
88Alveolar cell carcinoma (HP:0006519)1.82726376
89Keratoconus (HP:0000563)1.80881520
90Increased corneal curvature (HP:0100692)1.80881520
91Medial flaring of the eyebrow (HP:0010747)1.76824370
92Abnormality of T cells (HP:0002843)1.76067153
93Azoospermia (HP:0000027)1.75549353
94Abnormality of renal resorption (HP:0011038)1.75098723
95Methylmalonic aciduria (HP:0012120)1.74934548
96Congenital sensorineural hearing impairment (HP:0008527)1.74852834
97Abnormal spermatogenesis (HP:0008669)1.74580838
98Aplasia/Hypoplasia of the fovea (HP:0008060)1.74147924
99Hypoplasia of the fovea (HP:0007750)1.74147924
100Muscle fiber atrophy (HP:0100295)1.74098422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK66.17480052
2MST43.68686591
3TXK3.26856522
4BUB13.20676752
5ZAK2.77759118
6TAOK32.74865059
7TLK12.67701317
8NUAK12.59903843
9NEK12.45818409
10VRK22.40824783
11EIF2AK32.22943680
12EIF2AK12.10849139
13SRPK12.04244625
14TAF11.88358070
15MAP3K121.85259696
16PBK1.79710569
17PDK21.69716720
18AKT31.66588798
19PLK31.60644154
20FRK1.60607501
21BMPR1B1.59323072
22MKNK21.57535699
23VRK11.46970346
24ADRBK21.45176051
25GRK11.41572904
26INSRR1.40177965
27WNK41.35161301
28TIE11.34373975
29TESK11.33823160
30PINK11.28973008
31WNK31.25191777
32NME11.07991209
33CDK81.06217810
34STK391.06111661
35EIF2AK20.92399044
36ALK0.91474680
37MKNK10.87336071
38DYRK20.85160213
39NTRK10.82161165
40BMPR20.81099731
41OXSR10.78981930
42TEC0.77298785
43PHKG20.73802846
44PHKG10.73802846
45PLK20.72518451
46PIK3CG0.70963674
47ATR0.69407024
48IKBKB0.69113398
49LMTK20.68230109
50ITK0.67558254
51LIMK10.66759337
52MYLK0.64395158
53MAP4K10.61011563
54PNCK0.60473464
55BCKDK0.59746549
56CCNB10.59701189
57MAPK130.59455889
58TNK20.58861776
59TRIM280.55840975
60PRKCQ0.53373816
61FGFR10.50301819
62CSNK1G30.48171736
63PASK0.48153658
64CSNK1A1L0.46654078
65MAP4K20.46151466
66STK100.44892893
67MATK0.44090015
68TNIK0.42806729
69PAK30.42359571
70FLT30.41918377
71MARK30.40977802
72STK40.39279369
73CSNK1G10.38953211
74TTK0.38880240
75STK30.38743357
76CSNK1A10.38415936
77PRKCG0.38142482
78TGFBR10.38051459
79MARK10.37205653
80PLK10.36625473
81CSNK2A10.36107033
82CDC70.35906975
83KDR0.35783516
84CSNK1E0.35135631
85DAPK10.34324661
86WEE10.33956516
87CAMK2A0.33503675
88CSNK1G20.32852375
89CSNK2A20.32755400
90PRKG10.31213480
91SYK0.30663203
92MAPKAPK50.30658406
93PTK2B0.30632161
94MAP2K60.30476850
95LCK0.28329662
96ATM0.28093333
97AURKB0.27819115
98GRK50.27675021
99PRKCA0.27650095
100PRKACA0.27288960

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.21517916
2Caffeine metabolism_Homo sapiens_hsa002323.20412470
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17000176
4Protein export_Homo sapiens_hsa030603.15177938
5Oxidative phosphorylation_Homo sapiens_hsa001902.96736341
6Allograft rejection_Homo sapiens_hsa053302.87655128
7Asthma_Homo sapiens_hsa053102.78758377
8RNA polymerase_Homo sapiens_hsa030202.64634888
9Autoimmune thyroid disease_Homo sapiens_hsa053202.42910918
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.38998899
11Parkinsons disease_Homo sapiens_hsa050122.32547028
12One carbon pool by folate_Homo sapiens_hsa006702.07613332
13Type I diabetes mellitus_Homo sapiens_hsa049401.90803579
14Basal transcription factors_Homo sapiens_hsa030221.89736566
15Graft-versus-host disease_Homo sapiens_hsa053321.77352693
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76036671
17Sulfur metabolism_Homo sapiens_hsa009201.63890950
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56396645
19Rheumatoid arthritis_Homo sapiens_hsa053231.52658738
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52348080
21Propanoate metabolism_Homo sapiens_hsa006401.47810948
22Non-homologous end-joining_Homo sapiens_hsa034501.46102071
23Huntingtons disease_Homo sapiens_hsa050161.44007937
24Homologous recombination_Homo sapiens_hsa034401.41604783
25RNA degradation_Homo sapiens_hsa030181.41206777
26Alzheimers disease_Homo sapiens_hsa050101.39236133
27Collecting duct acid secretion_Homo sapiens_hsa049661.34558259
28Antigen processing and presentation_Homo sapiens_hsa046121.30996961
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25180432
30RNA transport_Homo sapiens_hsa030131.22768451
31Linoleic acid metabolism_Homo sapiens_hsa005911.21438582
32Vitamin B6 metabolism_Homo sapiens_hsa007501.20456098
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15627640
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14252976
35Tryptophan metabolism_Homo sapiens_hsa003801.14018775
36Mismatch repair_Homo sapiens_hsa034301.11455797
37Pyrimidine metabolism_Homo sapiens_hsa002401.11236568
38Primary immunodeficiency_Homo sapiens_hsa053401.02438168
39Phototransduction_Homo sapiens_hsa047441.01474958
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98726941
41Spliceosome_Homo sapiens_hsa030400.94561482
42Cardiac muscle contraction_Homo sapiens_hsa042600.93789788
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92210326
44Fanconi anemia pathway_Homo sapiens_hsa034600.91852317
45Hematopoietic cell lineage_Homo sapiens_hsa046400.88935594
46Nucleotide excision repair_Homo sapiens_hsa034200.88454890
47Ribosome_Homo sapiens_hsa030100.87374010
48Purine metabolism_Homo sapiens_hsa002300.87217522
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85523281
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84963265
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82991045
52Selenocompound metabolism_Homo sapiens_hsa004500.82495300
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79911447
54Butanoate metabolism_Homo sapiens_hsa006500.79540870
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.79020581
56Fat digestion and absorption_Homo sapiens_hsa049750.70547309
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.68952312
58Base excision repair_Homo sapiens_hsa034100.66259676
59DNA replication_Homo sapiens_hsa030300.65742434
60Nitrogen metabolism_Homo sapiens_hsa009100.65638216
61Viral myocarditis_Homo sapiens_hsa054160.64993830
62Chemical carcinogenesis_Homo sapiens_hsa052040.64823122
63Folate biosynthesis_Homo sapiens_hsa007900.63343401
64Systemic lupus erythematosus_Homo sapiens_hsa053220.62036380
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61185878
66Epstein-Barr virus infection_Homo sapiens_hsa051690.60868851
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59826661
68Peroxisome_Homo sapiens_hsa041460.59444710
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.57564467
70Regulation of autophagy_Homo sapiens_hsa041400.57002366
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56877942
72Metabolic pathways_Homo sapiens_hsa011000.55568984
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54386479
74beta-Alanine metabolism_Homo sapiens_hsa004100.53572947
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51306401
76Vitamin digestion and absorption_Homo sapiens_hsa049770.51306082
77Vibrio cholerae infection_Homo sapiens_hsa051100.51198137
78Steroid biosynthesis_Homo sapiens_hsa001000.51031059
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50900913
80Measles_Homo sapiens_hsa051620.44900880
81N-Glycan biosynthesis_Homo sapiens_hsa005100.44280974
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.41065203
83Ether lipid metabolism_Homo sapiens_hsa005650.39807104
84Olfactory transduction_Homo sapiens_hsa047400.38997852
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.38288744
86Pyruvate metabolism_Homo sapiens_hsa006200.37251018
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34279562
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34132192
89T cell receptor signaling pathway_Homo sapiens_hsa046600.33440876
90Taste transduction_Homo sapiens_hsa047420.30945307
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30290555
92Retinol metabolism_Homo sapiens_hsa008300.30180311
93Fatty acid degradation_Homo sapiens_hsa000710.29767840
94Nicotine addiction_Homo sapiens_hsa050330.28296528
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24772336
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.21510103
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21420489
98Arachidonic acid metabolism_Homo sapiens_hsa005900.19930096
99Arginine and proline metabolism_Homo sapiens_hsa003300.19720966
100Mineral absorption_Homo sapiens_hsa049780.19466329

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