

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 6.40470638 |
| 2 | DNA deamination (GO:0045006) | 5.51747523 |
| 3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.25606554 |
| 4 | transcription from mitochondrial promoter (GO:0006390) | 4.45513612 |
| 5 | rRNA modification (GO:0000154) | 4.40169354 |
| 6 | ATP synthesis coupled proton transport (GO:0015986) | 4.38983026 |
| 7 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.38983026 |
| 8 | chaperone-mediated protein transport (GO:0072321) | 4.08881975 |
| 9 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.98680154 |
| 10 | rRNA methylation (GO:0031167) | 3.97415987 |
| 11 | DNA double-strand break processing (GO:0000729) | 3.95408246 |
| 12 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.91237410 |
| 13 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.88735440 |
| 14 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.86702453 |
| 15 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.74283567 |
| 16 | isotype switching (GO:0045190) | 3.74283567 |
| 17 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.74283567 |
| 18 | termination of RNA polymerase III transcription (GO:0006386) | 3.72438746 |
| 19 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.72438746 |
| 20 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.71596125 |
| 21 | protein deneddylation (GO:0000338) | 3.70358641 |
| 22 | cullin deneddylation (GO:0010388) | 3.70223007 |
| 23 | mitochondrial RNA metabolic process (GO:0000959) | 3.69662056 |
| 24 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.65762603 |
| 25 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.63108331 |
| 26 | respiratory chain complex IV assembly (GO:0008535) | 3.58076777 |
| 27 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.53241800 |
| 28 | pseudouridine synthesis (GO:0001522) | 3.53096310 |
| 29 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.52482824 |
| 30 | regulation of immunoglobulin secretion (GO:0051023) | 3.52077520 |
| 31 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.51757836 |
| 32 | negative regulation of ligase activity (GO:0051352) | 3.51757836 |
| 33 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.51729617 |
| 34 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.48458310 |
| 35 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.48458310 |
| 36 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.48458310 |
| 37 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.44081001 |
| 38 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.44081001 |
| 39 | protein complex biogenesis (GO:0070271) | 3.41325586 |
| 40 | maturation of 5.8S rRNA (GO:0000460) | 3.34330244 |
| 41 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.32562110 |
| 42 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.31780744 |
| 43 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.31780744 |
| 44 | L-fucose metabolic process (GO:0042354) | 3.30121717 |
| 45 | L-fucose catabolic process (GO:0042355) | 3.30121717 |
| 46 | fucose catabolic process (GO:0019317) | 3.30121717 |
| 47 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.27486600 |
| 48 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.27192100 |
| 49 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339 | 3.27019539 |
| 50 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.26558985 |
| 51 | protein-cofactor linkage (GO:0018065) | 3.24291193 |
| 52 | termination of RNA polymerase I transcription (GO:0006363) | 3.23026610 |
| 53 | cytidine metabolic process (GO:0046087) | 3.17704305 |
| 54 | cytidine catabolic process (GO:0006216) | 3.17704305 |
| 55 | cytidine deamination (GO:0009972) | 3.17704305 |
| 56 | cytochrome complex assembly (GO:0017004) | 3.16830051 |
| 57 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.16590859 |
| 58 | mannosylation (GO:0097502) | 3.16498173 |
| 59 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.15484311 |
| 60 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.15484311 |
| 61 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.15253240 |
| 62 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.14543610 |
| 63 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.14543610 |
| 64 | T cell differentiation involved in immune response (GO:0002292) | 3.14543610 |
| 65 | ribosome assembly (GO:0042255) | 3.12556212 |
| 66 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.12104791 |
| 67 | NADH dehydrogenase complex assembly (GO:0010257) | 3.12104791 |
| 68 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.12104791 |
| 69 | protein neddylation (GO:0045116) | 3.07289414 |
| 70 | positive regulation of ligase activity (GO:0051351) | 3.06148006 |
| 71 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.01602476 |
| 72 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.00544828 |
| 73 | signal peptide processing (GO:0006465) | 2.99934463 |
| 74 | electron transport chain (GO:0022900) | 2.96748113 |
| 75 | respiratory electron transport chain (GO:0022904) | 2.96182408 |
| 76 | intracellular protein transmembrane import (GO:0044743) | 2.95832592 |
| 77 | positive regulation of chemokine biosynthetic process (GO:0045080) | 2.95306363 |
| 78 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.92335653 |
| 79 | regulation of cellular amine metabolic process (GO:0033238) | 2.90493129 |
| 80 | regulation of chronic inflammatory response (GO:0002676) | 2.84728962 |
| 81 | kynurenine metabolic process (GO:0070189) | 2.82405349 |
| 82 | GTP biosynthetic process (GO:0006183) | 2.79574468 |
| 83 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.79208873 |
| 84 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 2.77909157 |
| 85 | tRNA processing (GO:0008033) | 2.76295416 |
| 86 | rRNA processing (GO:0006364) | 2.75876107 |
| 87 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 2.75679568 |
| 88 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.75093523 |
| 89 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.74233076 |
| 90 | rRNA metabolic process (GO:0016072) | 2.74196263 |
| 91 | behavioral response to nicotine (GO:0035095) | 2.73652345 |
| 92 | DNA damage response, detection of DNA damage (GO:0042769) | 2.73226845 |
| 93 | tRNA metabolic process (GO:0006399) | 2.73080581 |
| 94 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.72885153 |
| 95 | positive regulation of cell cycle arrest (GO:0071158) | 2.71891144 |
| 96 | hydrogen ion transmembrane transport (GO:1902600) | 2.71683463 |
| 97 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.69960870 |
| 98 | negative regulation of T cell differentiation in thymus (GO:0033085) | 2.68289479 |
| 99 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.67350424 |
| 100 | regulation of ligase activity (GO:0051340) | 2.67331107 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.83932887 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.45687444 |
| 3 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.33940889 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.66748502 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.11042721 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.00478380 |
| 7 | VDR_22108803_ChIP-Seq_LS180_Human | 2.98323405 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.94044539 |
| 9 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.85942811 |
| 10 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.85701524 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.81024254 |
| 12 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.64292838 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.59535194 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.50341290 |
| 15 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.43841553 |
| 16 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.43552917 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.21834814 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.07432313 |
| 19 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.02284079 |
| 20 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.01435446 |
| 21 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.94546764 |
| 22 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.83643571 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.82246711 |
| 24 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.80702660 |
| 25 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.80472052 |
| 26 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.78952404 |
| 27 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.75301626 |
| 28 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.73587607 |
| 29 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.73278341 |
| 30 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.73069206 |
| 31 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.65648930 |
| 32 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.64591818 |
| 33 | EWS_26573619_Chip-Seq_HEK293_Human | 1.61705411 |
| 34 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.58679447 |
| 35 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.55328537 |
| 36 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.53640146 |
| 37 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.49300146 |
| 38 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.46011241 |
| 39 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.43766269 |
| 40 | GATA1_22025678_ChIP-Seq_K562_Human | 1.42844268 |
| 41 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.41310573 |
| 42 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.39823637 |
| 43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.37637254 |
| 44 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.37635647 |
| 45 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.36221546 |
| 46 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.34003687 |
| 47 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.32797903 |
| 48 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.30560814 |
| 49 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.30234576 |
| 50 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.29902687 |
| 51 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.29534289 |
| 52 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.27066004 |
| 53 | FUS_26573619_Chip-Seq_HEK293_Human | 1.25132446 |
| 54 | P300_19829295_ChIP-Seq_ESCs_Human | 1.24546813 |
| 55 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.23216145 |
| 56 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.22850163 |
| 57 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.22318931 |
| 58 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.15906228 |
| 59 | GATA3_26560356_Chip-Seq_TH2_Human | 1.13349404 |
| 60 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.10773668 |
| 61 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.07945312 |
| 62 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.07945312 |
| 63 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.06185604 |
| 64 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.04036327 |
| 65 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.03108592 |
| 66 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.02914503 |
| 67 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.02914503 |
| 68 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.02768137 |
| 69 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.02258675 |
| 70 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.01451399 |
| 71 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.00427213 |
| 72 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.99895390 |
| 73 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.99050806 |
| 74 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.98843211 |
| 75 | NCOR_22424771_ChIP-Seq_293T_Human | 0.97004989 |
| 76 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.96812409 |
| 77 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.95563542 |
| 78 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.95563542 |
| 79 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.94319592 |
| 80 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.93996702 |
| 81 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.92734283 |
| 82 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.92608199 |
| 83 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.92533411 |
| 84 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.90813622 |
| 85 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.90375932 |
| 86 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.90325601 |
| 87 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.89439777 |
| 88 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.88215493 |
| 89 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.88186733 |
| 90 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.88024221 |
| 91 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.87589617 |
| 92 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.86843650 |
| 93 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.86016119 |
| 94 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.85797619 |
| 95 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.85717005 |
| 96 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.83760531 |
| 97 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.82759360 |
| 98 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.82730711 |
| 99 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.82266348 |
| 100 | AR_20517297_ChIP-Seq_VCAP_Human | 0.82117410 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008875_abnormal_xenobiotic_pharmacok | 3.68811068 |
| 2 | MP0001835_abnormal_antigen_presentation | 3.23924023 |
| 3 | MP0001873_stomach_inflammation | 3.12013953 |
| 4 | MP0000569_abnormal_digit_pigmentation | 3.00440183 |
| 5 | MP0005671_abnormal_response_to | 2.74085089 |
| 6 | MP0005360_urolithiasis | 2.73590737 |
| 7 | MP0001984_abnormal_olfaction | 2.62596541 |
| 8 | MP0002163_abnormal_gland_morphology | 2.47045947 |
| 9 | MP0006072_abnormal_retinal_apoptosis | 2.37836777 |
| 10 | MP0002837_dystrophic_cardiac_calcinosis | 2.35453680 |
| 11 | MP0002102_abnormal_ear_morphology | 2.19513283 |
| 12 | MP0003186_abnormal_redox_activity | 2.18837427 |
| 13 | MP0005379_endocrine/exocrine_gland_phen | 2.18404068 |
| 14 | MP0008872_abnormal_physiological_respon | 2.18308753 |
| 15 | MP0003806_abnormal_nucleotide_metabolis | 2.05096401 |
| 16 | MP0009333_abnormal_splenocyte_physiolog | 1.93324078 |
| 17 | MP0009785_altered_susceptibility_to | 1.87619294 |
| 18 | MP0005387_immune_system_phenotype | 1.87127811 |
| 19 | MP0001790_abnormal_immune_system | 1.87127811 |
| 20 | MP0001348_abnormal_lacrimal_gland | 1.86073796 |
| 21 | MP0004145_abnormal_muscle_electrophysio | 1.83164339 |
| 22 | MP0008877_abnormal_DNA_methylation | 1.78371062 |
| 23 | MP0001501_abnormal_sleep_pattern | 1.73082992 |
| 24 | MP0002148_abnormal_hypersensitivity_rea | 1.71826490 |
| 25 | MP0000372_irregular_coat_pigmentation | 1.70280408 |
| 26 | MP0002166_altered_tumor_susceptibility | 1.62468393 |
| 27 | MP0003718_maternal_effect | 1.58245928 |
| 28 | MP0005645_abnormal_hypothalamus_physiol | 1.56832420 |
| 29 | MP0003195_calcinosis | 1.55416579 |
| 30 | MP0002006_tumorigenesis | 1.51309333 |
| 31 | MP0008058_abnormal_DNA_repair | 1.50657776 |
| 32 | MP0000685_abnormal_immune_system | 1.49920495 |
| 33 | MP0002138_abnormal_hepatobiliary_system | 1.48608404 |
| 34 | MP0005085_abnormal_gallbladder_physiolo | 1.48366349 |
| 35 | MP0005551_abnormal_eye_electrophysiolog | 1.48262985 |
| 36 | MP0004742_abnormal_vestibular_system | 1.44114869 |
| 37 | MP0005084_abnormal_gallbladder_morpholo | 1.39789545 |
| 38 | MP0001800_abnormal_humoral_immune | 1.38052868 |
| 39 | MP0004142_abnormal_muscle_tone | 1.37221341 |
| 40 | MP0002272_abnormal_nervous_system | 1.37212966 |
| 41 | MP0001919_abnormal_reproductive_system | 1.35695303 |
| 42 | MP0001905_abnormal_dopamine_level | 1.34880944 |
| 43 | MP0001968_abnormal_touch/_nociception | 1.33930477 |
| 44 | MP0005408_hypopigmentation | 1.29880648 |
| 45 | MP0003646_muscle_fatigue | 1.29859037 |
| 46 | MP0003693_abnormal_embryo_hatching | 1.29537710 |
| 47 | MP0005389_reproductive_system_phenotype | 1.29510016 |
| 48 | MP0008007_abnormal_cellular_replicative | 1.25934737 |
| 49 | MP0003786_premature_aging | 1.25423441 |
| 50 | MP0004957_abnormal_blastocyst_morpholog | 1.22810987 |
| 51 | MP0003950_abnormal_plasma_membrane | 1.21384241 |
| 52 | MP0003252_abnormal_bile_duct | 1.19232069 |
| 53 | MP0005171_absent_coat_pigmentation | 1.18649943 |
| 54 | MP0002876_abnormal_thyroid_physiology | 1.18029080 |
| 55 | MP0004782_abnormal_surfactant_physiolog | 1.17051060 |
| 56 | MP0003763_abnormal_thymus_physiology | 1.16126408 |
| 57 | MP0006082_CNS_inflammation | 1.13259692 |
| 58 | MP0001440_abnormal_grooming_behavior | 1.11735211 |
| 59 | MP0000427_abnormal_hair_cycle | 1.11190342 |
| 60 | MP0009046_muscle_twitch | 1.10739519 |
| 61 | MP0009745_abnormal_behavioral_response | 1.10151017 |
| 62 | MP0000371_diluted_coat_color | 1.07671440 |
| 63 | MP0006036_abnormal_mitochondrial_physio | 1.07239985 |
| 64 | MP0009697_abnormal_copulation | 1.06672633 |
| 65 | MP0005253_abnormal_eye_physiology | 1.05387666 |
| 66 | MP0002277_abnormal_respiratory_mucosa | 1.04140661 |
| 67 | MP0005636_abnormal_mineral_homeostasis | 1.02628785 |
| 68 | MP0005000_abnormal_immune_tolerance | 1.01491290 |
| 69 | MP0002938_white_spotting | 1.00385378 |
| 70 | MP0001529_abnormal_vocalization | 1.00363264 |
| 71 | MP0003567_abnormal_fetal_cardiomyocyte | 0.99796254 |
| 72 | MP0010094_abnormal_chromosome_stability | 0.97408653 |
| 73 | MP0002160_abnormal_reproductive_system | 0.96135992 |
| 74 | MP0005332_abnormal_amino_acid | 0.94296602 |
| 75 | MP0001188_hyperpigmentation | 0.93920373 |
| 76 | MP0005310_abnormal_salivary_gland | 0.93069185 |
| 77 | MP0005075_abnormal_melanosome_morpholog | 0.91354310 |
| 78 | MP0005365_abnormal_bile_salt | 0.89459897 |
| 79 | MP0002095_abnormal_skin_pigmentation | 0.89077348 |
| 80 | MP0001502_abnormal_circadian_rhythm | 0.89009013 |
| 81 | MP0001881_abnormal_mammary_gland | 0.88356222 |
| 82 | MP0006035_abnormal_mitochondrial_morpho | 0.85766482 |
| 83 | MP0002723_abnormal_immune_serum | 0.85243997 |
| 84 | MP0000538_abnormal_urinary_bladder | 0.85048316 |
| 85 | MP0002452_abnormal_antigen_presenting | 0.82769508 |
| 86 | MP0004381_abnormal_hair_follicle | 0.82130975 |
| 87 | MP0001663_abnormal_digestive_system | 0.81689727 |
| 88 | MP0001485_abnormal_pinna_reflex | 0.79641025 |
| 89 | MP0004043_abnormal_pH_regulation | 0.78548039 |
| 90 | MP0010386_abnormal_urinary_bladder | 0.77705408 |
| 91 | MP0004215_abnormal_myocardial_fiber | 0.77247887 |
| 92 | MP0002736_abnormal_nociception_after | 0.77025508 |
| 93 | MP0006276_abnormal_autonomic_nervous | 0.76302179 |
| 94 | MP0002733_abnormal_thermal_nociception | 0.75613643 |
| 95 | MP0000647_abnormal_sebaceous_gland | 0.75610085 |
| 96 | MP0003866_abnormal_defecation | 0.74044889 |
| 97 | MP0002420_abnormal_adaptive_immunity | 0.71506108 |
| 98 | MP0005410_abnormal_fertilization | 0.71442620 |
| 99 | MP0005167_abnormal_blood-brain_barrier | 0.70610185 |
| 100 | MP0002210_abnormal_sex_determination | 0.70502203 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.44987373 |
| 2 | Acute encephalopathy (HP:0006846) | 4.04618447 |
| 3 | Increased CSF lactate (HP:0002490) | 3.93588638 |
| 4 | Stomatitis (HP:0010280) | 3.90240167 |
| 5 | Mitochondrial inheritance (HP:0001427) | 3.89646657 |
| 6 | Progressive macrocephaly (HP:0004481) | 3.88183704 |
| 7 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.75881471 |
| 8 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.62423230 |
| 9 | Abnormality of alanine metabolism (HP:0010916) | 3.62423230 |
| 10 | Hyperalaninemia (HP:0003348) | 3.62423230 |
| 11 | Lipid accumulation in hepatocytes (HP:0006561) | 3.57209946 |
| 12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.26522166 |
| 13 | Hepatocellular necrosis (HP:0001404) | 3.23628646 |
| 14 | Type II lissencephaly (HP:0007260) | 3.23272365 |
| 15 | IgG deficiency (HP:0004315) | 3.20187842 |
| 16 | Increased serum lactate (HP:0002151) | 3.10612012 |
| 17 | Hepatic necrosis (HP:0002605) | 3.08604909 |
| 18 | Abnormality of the pons (HP:0007361) | 3.03619742 |
| 19 | 3-Methylglutaconic aciduria (HP:0003535) | 3.01200488 |
| 20 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.86977613 |
| 21 | Renal Fanconi syndrome (HP:0001994) | 2.85946139 |
| 22 | Pancreatic cysts (HP:0001737) | 2.79393558 |
| 23 | Cerebral edema (HP:0002181) | 2.76093771 |
| 24 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.64406747 |
| 25 | Abnormality of the labia minora (HP:0012880) | 2.63681795 |
| 26 | Hypomagnesemia (HP:0002917) | 2.63232253 |
| 27 | Hypoplasia of the pons (HP:0012110) | 2.62468186 |
| 28 | Abnormality of the anterior horn cell (HP:0006802) | 2.61895621 |
| 29 | Degeneration of anterior horn cells (HP:0002398) | 2.61895621 |
| 30 | Congenital, generalized hypertrichosis (HP:0004540) | 2.53466857 |
| 31 | Hypoproteinemia (HP:0003075) | 2.44452774 |
| 32 | Lactic acidosis (HP:0003128) | 2.44129758 |
| 33 | Optic disc pallor (HP:0000543) | 2.43651528 |
| 34 | Renal cortical cysts (HP:0000803) | 2.41531236 |
| 35 | Leukodystrophy (HP:0002415) | 2.38104585 |
| 36 | Hypothermia (HP:0002045) | 2.36630338 |
| 37 | Respiratory failure (HP:0002878) | 2.34202439 |
| 38 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.33990082 |
| 39 | Abnormality of magnesium homeostasis (HP:0004921) | 2.30511572 |
| 40 | Type I transferrin isoform profile (HP:0003642) | 2.28102699 |
| 41 | Increased serum pyruvate (HP:0003542) | 2.27861641 |
| 42 | Cerebellar dysplasia (HP:0007033) | 2.23120901 |
| 43 | Abnormality of glycolysis (HP:0004366) | 2.22784636 |
| 44 | Congenital stationary night blindness (HP:0007642) | 2.20747834 |
| 45 | Increased IgM level (HP:0003496) | 2.20452113 |
| 46 | Large for gestational age (HP:0001520) | 2.16817801 |
| 47 | Aplastic anemia (HP:0001915) | 2.16162390 |
| 48 | Hypoplasia of the uterus (HP:0000013) | 2.15511072 |
| 49 | Lethargy (HP:0001254) | 2.14471547 |
| 50 | Molar tooth sign on MRI (HP:0002419) | 2.12943535 |
| 51 | Abnormality of midbrain morphology (HP:0002418) | 2.12943535 |
| 52 | Cleft eyelid (HP:0000625) | 2.11733561 |
| 53 | Exertional dyspnea (HP:0002875) | 2.09639257 |
| 54 | Fibular aplasia (HP:0002990) | 2.08995927 |
| 55 | Posterior subcapsular cataract (HP:0007787) | 2.08717844 |
| 56 | Spastic paraparesis (HP:0002313) | 2.02844697 |
| 57 | Pancreatic fibrosis (HP:0100732) | 2.02824394 |
| 58 | Exercise intolerance (HP:0003546) | 2.02288837 |
| 59 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.02112467 |
| 60 | Gaze-evoked nystagmus (HP:0000640) | 2.01129015 |
| 61 | Tongue fasciculations (HP:0001308) | 2.00219662 |
| 62 | Adactyly (HP:0009776) | 2.00149928 |
| 63 | Abnormality of the renal cortex (HP:0011035) | 1.99880253 |
| 64 | Increased intramyocellular lipid droplets (HP:0012240) | 1.99409268 |
| 65 | Opisthotonus (HP:0002179) | 1.98635257 |
| 66 | Abnormality of T cell physiology (HP:0011840) | 1.98230844 |
| 67 | True hermaphroditism (HP:0010459) | 1.97396821 |
| 68 | Generalized aminoaciduria (HP:0002909) | 1.97173867 |
| 69 | Parakeratosis (HP:0001036) | 1.96632854 |
| 70 | Severe muscular hypotonia (HP:0006829) | 1.96353340 |
| 71 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.96301558 |
| 72 | Constricted visual fields (HP:0001133) | 1.96266962 |
| 73 | Type 2 muscle fiber atrophy (HP:0003554) | 1.95853924 |
| 74 | Chronic diarrhea (HP:0002028) | 1.95378798 |
| 75 | Megaloblastic anemia (HP:0001889) | 1.94304228 |
| 76 | IgA deficiency (HP:0002720) | 1.94030625 |
| 77 | Meckel diverticulum (HP:0002245) | 1.93610557 |
| 78 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.93313545 |
| 79 | Hypoalbuminemia (HP:0003073) | 1.91811974 |
| 80 | Abnormal albumin level (HP:0012116) | 1.91811974 |
| 81 | Nephronophthisis (HP:0000090) | 1.90281890 |
| 82 | Increased muscle lipid content (HP:0009058) | 1.90093571 |
| 83 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.85761595 |
| 84 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.85761595 |
| 85 | Abnormality of urine glucose concentration (HP:0011016) | 1.84070427 |
| 86 | Glycosuria (HP:0003076) | 1.84070427 |
| 87 | Abnormality of the ileum (HP:0001549) | 1.83517278 |
| 88 | Alveolar cell carcinoma (HP:0006519) | 1.82726376 |
| 89 | Keratoconus (HP:0000563) | 1.80881520 |
| 90 | Increased corneal curvature (HP:0100692) | 1.80881520 |
| 91 | Medial flaring of the eyebrow (HP:0010747) | 1.76824370 |
| 92 | Abnormality of T cells (HP:0002843) | 1.76067153 |
| 93 | Azoospermia (HP:0000027) | 1.75549353 |
| 94 | Abnormality of renal resorption (HP:0011038) | 1.75098723 |
| 95 | Methylmalonic aciduria (HP:0012120) | 1.74934548 |
| 96 | Congenital sensorineural hearing impairment (HP:0008527) | 1.74852834 |
| 97 | Abnormal spermatogenesis (HP:0008669) | 1.74580838 |
| 98 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.74147924 |
| 99 | Hypoplasia of the fovea (HP:0007750) | 1.74147924 |
| 100 | Muscle fiber atrophy (HP:0100295) | 1.74098422 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TSSK6 | 6.17480052 |
| 2 | MST4 | 3.68686591 |
| 3 | TXK | 3.26856522 |
| 4 | BUB1 | 3.20676752 |
| 5 | ZAK | 2.77759118 |
| 6 | TAOK3 | 2.74865059 |
| 7 | TLK1 | 2.67701317 |
| 8 | NUAK1 | 2.59903843 |
| 9 | NEK1 | 2.45818409 |
| 10 | VRK2 | 2.40824783 |
| 11 | EIF2AK3 | 2.22943680 |
| 12 | EIF2AK1 | 2.10849139 |
| 13 | SRPK1 | 2.04244625 |
| 14 | TAF1 | 1.88358070 |
| 15 | MAP3K12 | 1.85259696 |
| 16 | PBK | 1.79710569 |
| 17 | PDK2 | 1.69716720 |
| 18 | AKT3 | 1.66588798 |
| 19 | PLK3 | 1.60644154 |
| 20 | FRK | 1.60607501 |
| 21 | BMPR1B | 1.59323072 |
| 22 | MKNK2 | 1.57535699 |
| 23 | VRK1 | 1.46970346 |
| 24 | ADRBK2 | 1.45176051 |
| 25 | GRK1 | 1.41572904 |
| 26 | INSRR | 1.40177965 |
| 27 | WNK4 | 1.35161301 |
| 28 | TIE1 | 1.34373975 |
| 29 | TESK1 | 1.33823160 |
| 30 | PINK1 | 1.28973008 |
| 31 | WNK3 | 1.25191777 |
| 32 | NME1 | 1.07991209 |
| 33 | CDK8 | 1.06217810 |
| 34 | STK39 | 1.06111661 |
| 35 | EIF2AK2 | 0.92399044 |
| 36 | ALK | 0.91474680 |
| 37 | MKNK1 | 0.87336071 |
| 38 | DYRK2 | 0.85160213 |
| 39 | NTRK1 | 0.82161165 |
| 40 | BMPR2 | 0.81099731 |
| 41 | OXSR1 | 0.78981930 |
| 42 | TEC | 0.77298785 |
| 43 | PHKG2 | 0.73802846 |
| 44 | PHKG1 | 0.73802846 |
| 45 | PLK2 | 0.72518451 |
| 46 | PIK3CG | 0.70963674 |
| 47 | ATR | 0.69407024 |
| 48 | IKBKB | 0.69113398 |
| 49 | LMTK2 | 0.68230109 |
| 50 | ITK | 0.67558254 |
| 51 | LIMK1 | 0.66759337 |
| 52 | MYLK | 0.64395158 |
| 53 | MAP4K1 | 0.61011563 |
| 54 | PNCK | 0.60473464 |
| 55 | BCKDK | 0.59746549 |
| 56 | CCNB1 | 0.59701189 |
| 57 | MAPK13 | 0.59455889 |
| 58 | TNK2 | 0.58861776 |
| 59 | TRIM28 | 0.55840975 |
| 60 | PRKCQ | 0.53373816 |
| 61 | FGFR1 | 0.50301819 |
| 62 | CSNK1G3 | 0.48171736 |
| 63 | PASK | 0.48153658 |
| 64 | CSNK1A1L | 0.46654078 |
| 65 | MAP4K2 | 0.46151466 |
| 66 | STK10 | 0.44892893 |
| 67 | MATK | 0.44090015 |
| 68 | TNIK | 0.42806729 |
| 69 | PAK3 | 0.42359571 |
| 70 | FLT3 | 0.41918377 |
| 71 | MARK3 | 0.40977802 |
| 72 | STK4 | 0.39279369 |
| 73 | CSNK1G1 | 0.38953211 |
| 74 | TTK | 0.38880240 |
| 75 | STK3 | 0.38743357 |
| 76 | CSNK1A1 | 0.38415936 |
| 77 | PRKCG | 0.38142482 |
| 78 | TGFBR1 | 0.38051459 |
| 79 | MARK1 | 0.37205653 |
| 80 | PLK1 | 0.36625473 |
| 81 | CSNK2A1 | 0.36107033 |
| 82 | CDC7 | 0.35906975 |
| 83 | KDR | 0.35783516 |
| 84 | CSNK1E | 0.35135631 |
| 85 | DAPK1 | 0.34324661 |
| 86 | WEE1 | 0.33956516 |
| 87 | CAMK2A | 0.33503675 |
| 88 | CSNK1G2 | 0.32852375 |
| 89 | CSNK2A2 | 0.32755400 |
| 90 | PRKG1 | 0.31213480 |
| 91 | SYK | 0.30663203 |
| 92 | MAPKAPK5 | 0.30658406 |
| 93 | PTK2B | 0.30632161 |
| 94 | MAP2K6 | 0.30476850 |
| 95 | LCK | 0.28329662 |
| 96 | ATM | 0.28093333 |
| 97 | AURKB | 0.27819115 |
| 98 | GRK5 | 0.27675021 |
| 99 | PRKCA | 0.27650095 |
| 100 | PRKACA | 0.27288960 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.21517916 |
| 2 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.20412470 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.17000176 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.15177938 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.96736341 |
| 6 | Allograft rejection_Homo sapiens_hsa05330 | 2.87655128 |
| 7 | Asthma_Homo sapiens_hsa05310 | 2.78758377 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.64634888 |
| 9 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.42910918 |
| 10 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.38998899 |
| 11 | Parkinsons disease_Homo sapiens_hsa05012 | 2.32547028 |
| 12 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.07613332 |
| 13 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.90803579 |
| 14 | Basal transcription factors_Homo sapiens_hsa03022 | 1.89736566 |
| 15 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.77352693 |
| 16 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.76036671 |
| 17 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.63890950 |
| 18 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.56396645 |
| 19 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.52658738 |
| 20 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.52348080 |
| 21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.47810948 |
| 22 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.46102071 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.44007937 |
| 24 | Homologous recombination_Homo sapiens_hsa03440 | 1.41604783 |
| 25 | RNA degradation_Homo sapiens_hsa03018 | 1.41206777 |
| 26 | Alzheimers disease_Homo sapiens_hsa05010 | 1.39236133 |
| 27 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.34558259 |
| 28 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.30996961 |
| 29 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.25180432 |
| 30 | RNA transport_Homo sapiens_hsa03013 | 1.22768451 |
| 31 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.21438582 |
| 32 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.20456098 |
| 33 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.15627640 |
| 34 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.14252976 |
| 35 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.14018775 |
| 36 | Mismatch repair_Homo sapiens_hsa03430 | 1.11455797 |
| 37 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.11236568 |
| 38 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.02438168 |
| 39 | Phototransduction_Homo sapiens_hsa04744 | 1.01474958 |
| 40 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.98726941 |
| 41 | Spliceosome_Homo sapiens_hsa03040 | 0.94561482 |
| 42 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.93789788 |
| 43 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.92210326 |
| 44 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.91852317 |
| 45 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.88935594 |
| 46 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.88454890 |
| 47 | Ribosome_Homo sapiens_hsa03010 | 0.87374010 |
| 48 | Purine metabolism_Homo sapiens_hsa00230 | 0.87217522 |
| 49 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.85523281 |
| 50 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.84963265 |
| 51 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.82991045 |
| 52 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.82495300 |
| 53 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.79911447 |
| 54 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.79540870 |
| 55 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.79020581 |
| 56 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.70547309 |
| 57 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.68952312 |
| 58 | Base excision repair_Homo sapiens_hsa03410 | 0.66259676 |
| 59 | DNA replication_Homo sapiens_hsa03030 | 0.65742434 |
| 60 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.65638216 |
| 61 | Viral myocarditis_Homo sapiens_hsa05416 | 0.64993830 |
| 62 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.64823122 |
| 63 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.63343401 |
| 64 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.62036380 |
| 65 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.61185878 |
| 66 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.60868851 |
| 67 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.59826661 |
| 68 | Peroxisome_Homo sapiens_hsa04146 | 0.59444710 |
| 69 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.57564467 |
| 70 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.57002366 |
| 71 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.56877942 |
| 72 | Metabolic pathways_Homo sapiens_hsa01100 | 0.55568984 |
| 73 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.54386479 |
| 74 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.53572947 |
| 75 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.51306401 |
| 76 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.51306082 |
| 77 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.51198137 |
| 78 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.51031059 |
| 79 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.50900913 |
| 80 | Measles_Homo sapiens_hsa05162 | 0.44900880 |
| 81 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.44280974 |
| 82 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.41065203 |
| 83 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.39807104 |
| 84 | Olfactory transduction_Homo sapiens_hsa04740 | 0.38997852 |
| 85 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.38288744 |
| 86 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.37251018 |
| 87 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.34279562 |
| 88 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.34132192 |
| 89 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.33440876 |
| 90 | Taste transduction_Homo sapiens_hsa04742 | 0.30945307 |
| 91 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.30290555 |
| 92 | Retinol metabolism_Homo sapiens_hsa00830 | 0.30180311 |
| 93 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.29767840 |
| 94 | Nicotine addiction_Homo sapiens_hsa05033 | 0.28296528 |
| 95 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.24772336 |
| 96 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.21510103 |
| 97 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.21420489 |
| 98 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.19930096 |
| 99 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.19720966 |
| 100 | Mineral absorption_Homo sapiens_hsa04978 | 0.19466329 |

