ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tongue development (GO:0043586)	7.76444604
2	cell aggregation (GO:0098743)	5.91562801
3	cartilage condensation (GO:0001502)	5.91562801
4	somitogenesis (GO:0001756)	5.70095324
5	lymphangiogenesis (GO:0001946)	5.63433730
6	resolution of meiotic recombination intermediates (GO:0000712)	5.63120344
7	anterior/posterior axis specification, embryo (GO:0008595)	5.57871312
8	musculoskeletal movement (GO:0050881)	5.34331919
9	multicellular organismal movement (GO:0050879)	5.34331919
10	segmentation (GO:0035282)	5.18085515
11	muscle cell cellular homeostasis (GO:0046716)	5.08803911
12	regulation of cytokine secretion involved in immune response (GO:0002739)	4.89118274
13	N-terminal protein amino acid acetylation (GO:0006474)	4.69170807
14	negative regulation of stem cell proliferation (GO:2000647)	4.50510664
15	positive regulation of protein kinase C signaling (GO:0090037)	4.08478192
16	organ induction (GO:0001759)	4.08085903
17	skeletal muscle tissue regeneration (GO:0043403)	3.95770381
18	positive regulation of vesicle fusion (GO:0031340)	3.94235658
19	skeletal muscle tissue development (GO:0007519)	3.90907469
20	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	3.88765423
21	response to pheromone (GO:0019236)	3.86850627
22	regulation of metalloenzyme activity (GO:0048552)	3.84346458
23	membrane raft organization (GO:0031579)	3.78554187
24	muscle tissue morphogenesis (GO:0060415)	3.75535418
25	regulation of hippo signaling (GO:0035330)	3.74308527
26	uterus development (GO:0060065)	3.66434821
27	mesenchymal-epithelial cell signaling (GO:0060638)	3.65690298
28	tRNA methylation (GO:0030488)	3.53446510
29	vagina development (GO:0060068)	3.52060676
30	skeletal muscle cell differentiation (GO:0035914)	3.47662059
31	midgut development (GO:0007494)	3.46506275
32	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	3.45402919
33	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.41865591
34	ER overload response (GO:0006983)	3.40965161
35	recombinational repair (GO:0000725)	3.40577618
36	indolalkylamine metabolic process (GO:0006586)	3.38426626
37	lactate metabolic process (GO:0006089)	3.37977104
38	regulation of organ formation (GO:0003156)	3.35206369
39	double-strand break repair via homologous recombination (GO:0000724)	3.32583640
40	regulation of helicase activity (GO:0051095)	3.30528521
41	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.21839308
42	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.21839308
43	positive regulation of T cell apoptotic process (GO:0070234)	3.21559329
44	response to nitrosative stress (GO:0051409)	3.20832361
45	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	3.19309875
46	regulation of cilium movement (GO:0003352)	3.17925428
47	DNA double-strand break processing (GO:0000729)	3.14675538
48	N-terminal protein amino acid modification (GO:0031365)	3.11814223
49	negative regulation of keratinocyte proliferation (GO:0010839)	3.08471038
50	intraciliary transport (GO:0042073)	3.06296955
51	dopaminergic neuron differentiation (GO:0071542)	3.04380629
52	replication fork processing (GO:0031297)	3.02568540
53	positive regulation of muscle cell differentiation (GO:0051149)	3.00888112
54	mammary gland development (GO:0030879)	2.98283408
55	positive regulation of protein autophosphorylation (GO:0031954)	2.94519705
56	regulation of keratinocyte proliferation (GO:0010837)	2.94235602
57	primitive streak formation (GO:0090009)	2.92092274
58	establishment of tissue polarity (GO:0007164)	2.91900894
59	establishment of planar polarity (GO:0001736)	2.91900894
60	DNA dealkylation (GO:0035510)	2.91659909
61	female genitalia development (GO:0030540)	2.91554928
62	regulation of integrin-mediated signaling pathway (GO:2001044)	2.91143019
63	negative regulation of JUN kinase activity (GO:0043508)	2.90231582
64	regulation of telomere maintenance (GO:0032204)	2.89538644
65	mRNA modification (GO:0016556)	2.89065254
66	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.88033895
67	indole-containing compound metabolic process (GO:0042430)	2.87389984
68	protein heterotetramerization (GO:0051290)	2.85361744
69	DNA strand renaturation (GO:0000733)	2.84183294
70	neural tube formation (GO:0001841)	2.80533624
71	striated muscle tissue development (GO:0014706)	2.79675607
72	positive regulation of protein deacetylation (GO:0090312)	2.78789558
73	negative chemotaxis (GO:0050919)	2.76104899
74	genitalia morphogenesis (GO:0035112)	2.75549429
75	ncRNA catabolic process (GO:0034661)	2.72219066
76	camera-type eye development (GO:0043010)	2.71932855
77	lateral sprouting from an epithelium (GO:0060601)	2.71496303
78	protein polyglutamylation (GO:0018095)	2.66724031
79	respiratory chain complex IV assembly (GO:0008535)	2.66380675
80	positive regulation of macrophage activation (GO:0043032)	2.65162267
81	regulation of thymocyte apoptotic process (GO:0070243)	2.63770742
82	N-acetylglucosamine metabolic process (GO:0006044)	2.63197205
83	serotonin metabolic process (GO:0042428)	2.63010603
84	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.62494509
85	membrane budding (GO:0006900)	2.62365627
86	oxidative demethylation (GO:0070989)	2.61157967
87	histone H2A acetylation (GO:0043968)	2.60505678
88	DNA demethylation (GO:0080111)	2.58677399
89	positive regulation of cytokinesis (GO:0032467)	2.57336116
90	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.57280397
91	platelet dense granule organization (GO:0060155)	2.56048177
92	regulation of T cell chemotaxis (GO:0010819)	2.55354872
93	positive regulation of T cell chemotaxis (GO:0010820)	2.55354872
94	neuronal action potential (GO:0019228)	2.54859221
95	7-methylguanosine mRNA capping (GO:0006370)	2.54523287
96	positive regulation of interleukin-8 secretion (GO:2000484)	2.53126240
97	neuromuscular synaptic transmission (GO:0007274)	2.52722018
98	endocardial cushion morphogenesis (GO:0003203)	2.52338042
99	signal peptide processing (GO:0006465)	2.52127179
100	muscle cell fate commitment (GO:0042693)	13.3936156

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.02265780
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	5.41646244
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	5.38369577
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.39832508
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.73511715
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.69767730
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.47422843
8	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.24535341
9	VDR_22108803_ChIP-Seq_LS180_Human	2.23404597
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.11828372
11	P300_19829295_ChIP-Seq_ESCs_Human	2.07421573
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.03861094
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.93734415
14	EWS_26573619_Chip-Seq_HEK293_Human	1.92834562
15	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.90837644
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.89577153
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.83931236
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83815319
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.82651899
20	FUS_26573619_Chip-Seq_HEK293_Human	1.78019037
21	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.74526999
22	BRD4_25478319_ChIP-Seq_HGPS_Human	1.67144828
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.65348615
24	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.65183869
25	STAT3_23295773_ChIP-Seq_U87_Human	1.61601644
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.61395180
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.59143013
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.56830471
29	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.55899976
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.54853503
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54853503
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54616884
33	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.51013223
34	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.49319354
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49155598
36	TP53_16413492_ChIP-PET_HCT116_Human	1.46606251
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.46279575
38	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.45819705
39	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.45819705
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45776196
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44018898
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.43526294
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43276323
44	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.43266064
45	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.40876545
46	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38874597
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38372381
48	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.38038459
49	RXR_22108803_ChIP-Seq_LS180_Human	1.37499212
50	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.32788416
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.31819816
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31224928
53	IGF1R_20145208_ChIP-Seq_DFB_Human	1.30021343
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.29580740
55	CJUN_26792858_Chip-Seq_BT549_Human	1.28686596
56	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.28115960
57	TP53_18474530_ChIP-ChIP_U2OS_Human	1.27304784
58	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.24980598
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24873193
60	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.23501315
61	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.22912820
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.20788144
63	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20691731
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19553678
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19553678
66	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.19553195
67	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.18810030
68	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.18611136
69	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.16770658
70	CDX2_22108803_ChIP-Seq_LS180_Human	1.16404875
71	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15551130
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14854989
73	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.13632226
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12229809
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11145637
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.10281435
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09374499
78	TCF4_23295773_ChIP-Seq_U87_Human	1.09249478
79	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.08792852
80	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08661581
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07166241
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05928054
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05556654
84	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.04857635
85	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.02885081
86	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02766622
87	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.01945535
88	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.01915221
89	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.01345375
90	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.00987810
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.00312154
92	MYC_18940864_ChIP-ChIP_HL60_Human	0.98659868
93	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98093918
94	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.97823415
95	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95818991
96	AR_25329375_ChIP-Seq_VCAP_Human	0.95485788
97	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.94884863
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94311696
99	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.94210002
100	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.93515523

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002234_abnormal_pharynx_morphology	8.87061102
2	MP0000569_abnormal_digit_pigmentation	5.02788320
3	MP0000750_abnormal_muscle_regeneration	4.24279854
4	MP0006054_spinal_hemorrhage	4.19089065
5	MP0003191_abnormal_cellular_cholesterol	3.97215358
6	MP0003950_abnormal_plasma_membrane	3.69409446
7	MP0000733_abnormal_muscle_development	3.39492511
8	MP0002108_abnormal_muscle_morphology	3.28729169
9	MP0009780_abnormal_chondrocyte_physiolo	3.14458817
10	MP0000013_abnormal_adipose_tissue	2.65104680
11	MP0005360_urolithiasis	2.64406944
12	MP0010368_abnormal_lymphatic_system	2.51669523
13	MP0003705_abnormal_hypodermis_morpholog	2.14475688
14	MP0010030_abnormal_orbit_morphology	2.10980775
15	MP0001853_heart_inflammation	1.99857881
16	MP0002282_abnormal_trachea_morphology	1.69697637
17	MP0004145_abnormal_muscle_electrophysio	1.61475778
18	MP0008875_abnormal_xenobiotic_pharmacok	1.60006177
19	MP0003959_abnormal_lean_body	1.59092275
20	MP0003121_genomic_imprinting	1.56661287
21	MP0002932_abnormal_joint_morphology	1.54623459
22	MP0000371_diluted_coat_color	1.52701368
23	MP0000762_abnormal_tongue_morphology	1.49380809
24	MP0005623_abnormal_meninges_morphology	1.42464301
25	MP0003937_abnormal_limbs/digits/tail_de	1.41645086
26	MP0003122_maternal_imprinting	1.38150734
27	MP0004133_heterotaxia	1.37509250
28	MP0006276_abnormal_autonomic_nervous	1.34441009
29	MP0003045_fibrosis	1.28143931
30	MP0000538_abnormal_urinary_bladder	1.28082997
31	MP0005171_absent_coat_pigmentation	1.27983542
32	MP0002160_abnormal_reproductive_system	1.24140618
33	MP0000759_abnormal_skeletal_muscle	1.18066290
34	MP0003755_abnormal_palate_morphology	1.16675100
35	MP0000372_irregular_coat_pigmentation	1.15487514
36	MP0003828_pulmonary_edema	1.14449623
37	MP0002938_white_spotting	1.08006946
38	MP0008775_abnormal_heart_ventricle	1.07346148
39	MP0001346_abnormal_lacrimal_gland	1.05450037
40	MP0005369_muscle_phenotype	1.04118110
41	MP0002653_abnormal_ependyma_morphology	1.02546688
42	MP0001286_abnormal_eye_development	1.02102489
43	MP0005408_hypopigmentation	0.99662550
44	MP0002106_abnormal_muscle_physiology	0.97746737
45	MP0004134_abnormal_chest_morphology	0.96110390
46	MP0000647_abnormal_sebaceous_gland	0.93903363
47	MP0004883_abnormal_blood_vessel	0.89561040
48	MP0004087_abnormal_muscle_fiber	0.88164540
49	MP0001879_abnormal_lymphatic_vessel	0.87945696
50	MP0003123_paternal_imprinting	0.87498215
51	MP0002114_abnormal_axial_skeleton	0.83043001
52	MP0003787_abnormal_imprinting	0.82214202
53	MP0001299_abnormal_eye_distance/	0.81747201
54	MP0000427_abnormal_hair_cycle	0.81743350
55	MP0001501_abnormal_sleep_pattern	0.81131094
56	MP0005503_abnormal_tendon_morphology	0.79871760
57	MP0003186_abnormal_redox_activity	0.78242246
58	MP0003935_abnormal_craniofacial_develop	0.77957705
59	MP0003942_abnormal_urinary_system	0.74739279
60	MP0003646_muscle_fatigue	0.74400052
61	MP0002269_muscular_atrophy	0.74027342
62	MP0005389_reproductive_system_phenotype	0.73901586
63	MP0002184_abnormal_innervation	0.73762145
64	MP0005410_abnormal_fertilization	0.72299577
65	MP0002009_preneoplasia	0.72039105
66	MP0009250_abnormal_appendicular_skeleto	0.71907799
67	MP0002113_abnormal_skeleton_development	0.71324742
68	MP0001984_abnormal_olfaction	0.71208440
69	MP0002168_other_aberrant_phenotype	0.69755467
70	MP0004142_abnormal_muscle_tone	0.69487890
71	MP0003890_abnormal_embryonic-extraembry	0.67305155
72	MP0002095_abnormal_skin_pigmentation	0.66360202
73	MP0002075_abnormal_coat/hair_pigmentati	0.65191529
74	MP0005174_abnormal_tail_pigmentation	0.63024981
75	MP0000751_myopathy	0.62337648
76	MP0000516_abnormal_urinary_system	0.61820368
77	MP0005367_renal/urinary_system_phenotyp	0.61820368
78	MP0009053_abnormal_anal_canal	0.61727454
79	MP0010386_abnormal_urinary_bladder	0.61508366
80	MP0003936_abnormal_reproductive_system	0.57413591
81	MP0000534_abnormal_ureter_morphology	0.57187049
82	MP0000003_abnormal_adipose_tissue	0.56819696
83	MP0002751_abnormal_autonomic_nervous	0.56746444
84	MP0005075_abnormal_melanosome_morpholog	0.56314235
85	MP0008058_abnormal_DNA_repair	0.56271098
86	MP0002272_abnormal_nervous_system	0.53373804
87	MP0005395_other_phenotype	0.52014683
88	MP0002971_abnormal_brown_adipose	0.51435158
89	MP0002177_abnormal_outer_ear	0.50364493
90	MP0000432_abnormal_head_morphology	0.49774990
91	MP0002109_abnormal_limb_morphology	0.48842348
92	MP0002233_abnormal_nose_morphology	0.48681231
93	MP0009697_abnormal_copulation	0.48666463
94	MP0002085_abnormal_embryonic_tissue	0.48578928
95	MP0000955_abnormal_spinal_cord	0.48277734
96	MP0005551_abnormal_eye_electrophysiolog	0.47624865
97	MP0002115_abnormal_skeleton_extremities	0.47506429
98	MP0001186_pigmentation_phenotype	0.47431941
99	MP0002638_abnormal_pupillary_reflex	0.47077019
100	MP0008438_abnormal_cutaneous_collagen	0.46304965

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Popliteal pterygium (HP:0009756)	7.14563762
2	Type 2 muscle fiber atrophy (HP:0003554)	6.28638465
3	Abnormality of placental membranes (HP:0011409)	6.11714177
4	Amniotic constriction ring (HP:0009775)	6.11714177
5	Aplasia of the musculature (HP:0100854)	5.67239965
6	Muscle fiber atrophy (HP:0100295)	5.52835916
7	Fatigable weakness (HP:0003473)	4.73687127
8	Abnormality of the neuromuscular junction (HP:0003398)	4.73687127
9	Short middle phalanx of the 5th finger (HP:0004220)	4.14066821
10	Fetal akinesia sequence (HP:0001989)	4.07592910
11	Weak cry (HP:0001612)	3.93458670
12	Chronic hepatic failure (HP:0100626)	3.86779017
13	Pterygium (HP:0001059)	3.56749224
14	Small hand (HP:0200055)	3.50281700
15	True hermaphroditism (HP:0010459)	3.42302249
16	Aplasia/Hypoplasia involving the musculature (HP:0001460)	3.33574595
17	Fair hair (HP:0002286)	3.23189074
18	Thin ribs (HP:0000883)	3.16816694
19	Pancreatic cysts (HP:0001737)	3.15191867
20	Mesomelia (HP:0003027)	2.99961439
21	Easy fatigability (HP:0003388)	2.96775434
22	Pancreatic fibrosis (HP:0100732)	2.95604411
23	Renal duplication (HP:0000075)	2.94647665
24	Nephronophthisis (HP:0000090)	2.90633840
25	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.88860607
26	Bifid tongue (HP:0010297)	2.88226776
27	Molar tooth sign on MRI (HP:0002419)	2.86819292
28	Abnormality of midbrain morphology (HP:0002418)	2.86819292
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.75665015
30	Gowers sign (HP:0003391)	2.69998289
31	Cystic hygroma (HP:0000476)	2.68953935
32	Concave nail (HP:0001598)	2.68317995
33	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.67719621
34	Volvulus (HP:0002580)	2.66213300
35	Malignant hyperthermia (HP:0002047)	2.63933980
36	Generalized hypopigmentation of hair (HP:0011358)	2.62281340
37	Febrile seizures (HP:0002373)	2.62049552
38	Atonic seizures (HP:0010819)	2.60055419
39	Absent frontal sinuses (HP:0002688)	2.53831020
40	Abnormality of the renal medulla (HP:0100957)	2.48306820
41	Poor coordination (HP:0002370)	2.47425065
42	Scanning speech (HP:0002168)	2.44335743
43	Glucose intolerance (HP:0000833)	2.43538578
44	Anencephaly (HP:0002323)	2.39692347
45	Increased number of teeth (HP:0011069)	2.38566371
46	Decreased muscle mass (HP:0003199)	2.34901930
47	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.33349263
48	Abnormalities of placenta or umbilical cord (HP:0001194)	2.32328520
49	Occipital encephalocele (HP:0002085)	2.32143270
50	Abnormality of the frontal sinuses (HP:0002687)	2.24456307
51	Depressed nasal tip (HP:0000437)	2.23032646
52	Failure to thrive in infancy (HP:0001531)	2.21030394
53	Akinesia (HP:0002304)	2.20166227
54	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.19193514
55	Abnormal hair whorl (HP:0010721)	2.17534966
56	Hypoplastic labia majora (HP:0000059)	2.16070080
57	Keratoconus (HP:0000563)	2.14436251
58	Increased corneal curvature (HP:0100692)	2.14436251
59	Nonprogressive disorder (HP:0003680)	2.04947491
60	Neonatal respiratory distress (HP:0002643)	2.04281314
61	Abnormality of the ischium (HP:0003174)	2.02991679
62	Chorioretinal atrophy (HP:0000533)	2.00965786
63	Hypoplastic ischia (HP:0003175)	1.98362002
64	Abnormal biliary tract physiology (HP:0012439)	1.98088087
65	Bile duct proliferation (HP:0001408)	1.98088087
66	Abnormality of the labia majora (HP:0012881)	1.97787078
67	Poor suck (HP:0002033)	1.95695520
68	Abnormality of the renal cortex (HP:0011035)	1.95345029
69	Delayed gross motor development (HP:0002194)	1.93772537
70	Nemaline bodies (HP:0003798)	1.93683188
71	Diminished movement (HP:0002374)	1.93063586
72	Male infertility (HP:0003251)	1.92150216
73	Narrow palate (HP:0000189)	1.89544165
74	Widely spaced teeth (HP:0000687)	1.89335926
75	Spontaneous abortion (HP:0005268)	1.87535500
76	Methylmalonic acidemia (HP:0002912)	1.85906863
77	Abnormal glucose tolerance (HP:0001952)	1.85616531
78	Postaxial foot polydactyly (HP:0001830)	1.85169060
79	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.85162157
80	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.85162157
81	Cystic liver disease (HP:0006706)	1.82718311
82	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.79833041
83	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.79775596
84	Hypobetalipoproteinemia (HP:0003563)	1.77490472
85	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.75624429
86	Short 5th finger (HP:0009237)	1.74813472
87	Congenital hepatic fibrosis (HP:0002612)	1.72960264
88	Supernumerary spleens (HP:0009799)	1.72025547
89	Renal cortical cysts (HP:0000803)	1.71608707
90	Colon cancer (HP:0003003)	1.70847346
91	Recurrent corneal erosions (HP:0000495)	1.69567950
92	Short palpebral fissure (HP:0012745)	1.69449999
93	Abnormality of the right ventricle (HP:0001707)	1.67909698
94	Coronal craniosynostosis (HP:0004440)	1.67688642
95	Meckel diverticulum (HP:0002245)	1.66680683
96	Long eyelashes (HP:0000527)	1.66555773
97	Absent phalangeal crease (HP:0006109)	1.66450435
98	Dialeptic seizures (HP:0011146)	1.66137212
99	Abnormality of the ileum (HP:0001549)	1.61590799
100	Narrow forehead (HP:0000341)	1.59914848

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MUSK	6.74392551
2	PRKD3	4.28871406
3	VRK2	3.87030630
4	NUAK1	3.62846062
5	EIF2AK3	3.61925572
6	MAP4K2	2.91752233
7	TAF1	2.86067935
8	STK16	2.43991639
9	FRK	2.41769449
10	AKT3	2.20460954
11	LIMK1	2.16876239
12	PDK2	2.08250659
13	MKNK2	1.73133981
14	MAP3K2	1.59567996
15	MAP3K10	1.58578587
16	MKNK1	1.48582159
17	SMG1	1.48354727
18	BRSK2	1.42713944
19	BRD4	1.36892822
20	TRIM28	1.33169293
21	MAPK13	1.32568343
22	CASK	1.32518682
23	SRPK1	1.31642577
24	PAK3	1.30877465
25	ERBB3	1.30158844
26	DYRK3	1.30128584
27	FGFR1	1.29009478
28	VRK1	1.28401943
29	MST4	1.26589649
30	BMPR2	1.17291982
31	NEK1	1.14301287
32	PRKD2	1.05948274
33	EIF2AK2	1.05822934
34	RPS6KA4	1.05076832
35	CHEK2	0.95054244
36	DYRK1A	0.92590468
37	TNIK	0.92369215
38	BRSK1	0.84021822
39	CSNK1G1	0.78865877
40	CAMK1D	0.78756191
41	OBSCN	0.77286315
42	PLK3	0.76081739
43	SGK2	0.75090399
44	GRK1	0.73533335
45	TEC	0.72358671
46	BCR	0.72146836
47	GSK3A	0.71793489
48	CSNK1A1L	0.70332532
49	MELK	0.67143221
50	CDK9	0.66990287
51	PLK2	0.65863733
52	DYRK2	0.64828357
53	ADRBK2	0.60142157
54	MAPKAPK5	0.57717986
55	PRKCH	0.57278285
56	WNK3	0.57058523
57	NLK	0.56705750
58	MYLK	0.56435420
59	CAMK2D	0.55773817
60	PRKCE	0.55136700
61	CAMK1G	0.54713520
62	CAMK2A	0.54237610
63	PIK3CG	0.54092265
64	WEE1	0.53523491
65	CAMK4	0.52863577
66	MAPK7	0.51863964
67	CSNK1G3	0.50014108
68	CHUK	0.49535285
69	PRKAA2	0.47454266
70	STK24	0.45894737
71	MAPK15	0.40367624
72	CDC7	0.38854881
73	CAMK2G	0.38815308
74	PRKDC	0.36129916
75	MINK1	0.34996319
76	GRK5	0.34085906
77	CSNK2A1	0.33886340
78	PAK6	0.33878483
79	CSNK1A1	0.33760260
80	CSNK2A2	0.33347933
81	INSR	0.32813619
82	CAMK2B	0.32218367
83	PINK1	0.32011122
84	PBK	0.31986386
85	PTK6	0.28957900
86	PTK2B	0.28847133
87	FGFR3	0.28640999
88	PRKCG	0.27498056
89	KDR	0.27391669
90	TRPM7	0.27175827
91	CSNK1G2	0.27069042
92	PRKAA1	0.26373811
93	STK38L	0.24379171
94	STK4	0.24327260
95	EPHA4	0.24308057
96	OXSR1	0.23989129
97	PKN1	0.22629983
98	ATM	0.21991049
99	SGK223	0.20595608
100	SGK494	0.20595608

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	5.75359626
2	Proteasome_Homo sapiens_hsa03050	3.22756942
3	Basal transcription factors_Homo sapiens_hsa03022	3.15790729
4	Propanoate metabolism_Homo sapiens_hsa00640	3.13322811
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.03402464
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.61673940
7	Folate biosynthesis_Homo sapiens_hsa00790	2.49599800
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.33048201
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.14432261
10	Tryptophan metabolism_Homo sapiens_hsa00380	2.01757673
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.73504804
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.70518157
13	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.70300581
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.67776705
15	RNA polymerase_Homo sapiens_hsa03020	1.67363048
16	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.67112101
17	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.64638927
18	Caffeine metabolism_Homo sapiens_hsa00232	1.56721041
19	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.49964760
20	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.46945784
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.37794766
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.29842500
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.29753845
24	RNA transport_Homo sapiens_hsa03013	1.29421550
25	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.27947829
26	Taste transduction_Homo sapiens_hsa04742	1.24409138
27	Melanoma_Homo sapiens_hsa05218	1.24182409
28	One carbon pool by folate_Homo sapiens_hsa00670	1.23866868
29	Homologous recombination_Homo sapiens_hsa03440	1.20695771
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19113626
31	Basal cell carcinoma_Homo sapiens_hsa05217	1.18533983
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.12625688
33	RNA degradation_Homo sapiens_hsa03018	1.12526752
34	Pyruvate metabolism_Homo sapiens_hsa00620	1.11577587
35	Phototransduction_Homo sapiens_hsa04744	1.10928193
36	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.08473866
37	Histidine metabolism_Homo sapiens_hsa00340	1.07890511
38	Adherens junction_Homo sapiens_hsa04520	1.04142024
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.01715626
40	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.01379261
41	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.01061731
42	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.00111644
43	Pyrimidine metabolism_Homo sapiens_hsa00240	0.97677196
44	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95414917
45	Prostate cancer_Homo sapiens_hsa05215	0.94939828
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.94937366
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92719829
48	Nucleotide excision repair_Homo sapiens_hsa03420	0.90379644
49	Hippo signaling pathway_Homo sapiens_hsa04390	0.88602453
50	Huntingtons disease_Homo sapiens_hsa05016	0.82550326
51	Thyroid cancer_Homo sapiens_hsa05216	0.79093673
52	Mismatch repair_Homo sapiens_hsa03430	0.78646364
53	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.77060634
54	Retinol metabolism_Homo sapiens_hsa00830	0.76782346
55	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.76357417
56	Sulfur metabolism_Homo sapiens_hsa00920	0.75882666
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.75000293
58	Complement and coagulation cascades_Homo sapiens_hsa04610	0.74790525
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74284343
60	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.73100635
61	Glutathione metabolism_Homo sapiens_hsa00480	0.71310690
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68216848
63	Serotonergic synapse_Homo sapiens_hsa04726	0.67562231
64	Fatty acid elongation_Homo sapiens_hsa00062	0.66427090
65	Cell cycle_Homo sapiens_hsa04110	0.63751266
66	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.63416656
67	Fatty acid degradation_Homo sapiens_hsa00071	0.58719234
68	Mineral absorption_Homo sapiens_hsa04978	0.57356295
69	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.57068604
70	Metabolic pathways_Homo sapiens_hsa01100	0.55798190
71	Tyrosine metabolism_Homo sapiens_hsa00350	0.54591564
72	Wnt signaling pathway_Homo sapiens_hsa04310	0.51480189
73	Purine metabolism_Homo sapiens_hsa00230	0.49633932
74	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.49579797
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.49082196
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.48650865
77	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.48480649
78	Circadian rhythm_Homo sapiens_hsa04710	0.47763916
79	Phenylalanine metabolism_Homo sapiens_hsa00360	0.46807500
80	Oxidative phosphorylation_Homo sapiens_hsa00190	0.44899400
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44163728
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42832845
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42738689
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42716534
85	Lysine degradation_Homo sapiens_hsa00310	0.42446684
86	Butanoate metabolism_Homo sapiens_hsa00650	0.41461862
87	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.41028216
88	Gap junction_Homo sapiens_hsa04540	0.40306480
89	Spliceosome_Homo sapiens_hsa03040	0.39903813
90	Alcoholism_Homo sapiens_hsa05034	0.38900752
91	Peroxisome_Homo sapiens_hsa04146	0.38492669
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.36203736
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34627225
94	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.31736035
95	Parkinsons disease_Homo sapiens_hsa05012	0.29243801
96	Focal adhesion_Homo sapiens_hsa04510	0.28731261
97	p53 signaling pathway_Homo sapiens_hsa04115	0.28673737
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.27714460
99	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.26864954
100	Pathways in cancer_Homo sapiens_hsa05200	0.26703914

HSPA8P19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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