HSPA8P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of protein sumoylation (GO:0033235)9.79367284
2negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 9.67968061
3synaptic transmission, dopaminergic (GO:0001963)9.39126607
4peptidyl-histidine modification (GO:0018202)9.15918411
5regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 8.12179429
6negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)7.26423896
7regulation of protein sumoylation (GO:0033233)6.45013477
8negative regulation of mast cell activation (GO:0033004)6.08610184
9keratinocyte development (GO:0003334)5.87542756
10regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)5.87248369
11tryptophan catabolic process (GO:0006569)5.77240629
12indole-containing compound catabolic process (GO:0042436)5.77240629
13indolalkylamine catabolic process (GO:0046218)5.77240629
14centriole replication (GO:0007099)5.55683668
15bundle of His cell to Purkinje myocyte communication (GO:0086069)5.47329438
16positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)5.47024825
17tryptophan metabolic process (GO:0006568)5.39773804
18positive regulation of interleukin-1 beta secretion (GO:0050718)5.15346958
19tumor necrosis factor-mediated signaling pathway (GO:0033209)5.15333022
20regulation of cAMP-mediated signaling (GO:0043949)5.06862132
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.94987930
22regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.93915273
23positive regulation of interleukin-1 secretion (GO:0050716)4.82846043
24negative regulation of nitric-oxide synthase activity (GO:0051001)4.76995787
25establishment of skin barrier (GO:0061436)4.72889626
26hair follicle development (GO:0001942)4.68340384
27regulation of action potential (GO:0098900)4.57155677
28regulation of interleukin-1 beta secretion (GO:0050706)4.55677801
29negative regulation of signal transduction by p53 class mediator (GO:1901797)4.53957208
30amyloid precursor protein catabolic process (GO:0042987)4.47797167
31DNA damage induced protein phosphorylation (GO:0006975)4.32158953
32GMP metabolic process (GO:0046037)4.31977805
33positive regulation of DNA-templated transcription, elongation (GO:0032786)4.28917861
34receptor recycling (GO:0001881)4.19012030
35deoxyribonucleoside diphosphate metabolic process (GO:0009186)4.05951676
36peroxisome fission (GO:0016559)4.01946772
37regulation of interleukin-1 secretion (GO:0050704)3.97037331
38nucleoside diphosphate catabolic process (GO:0009134)3.91868151
39mitochondrial calcium ion transport (GO:0006851)3.83224240
40regulation of female gonad development (GO:2000194)3.81908523
41indolalkylamine metabolic process (GO:0006586)3.76446344
42pituitary gland development (GO:0021983)3.73943358
43negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)3.73050203
44positive regulation of neural precursor cell proliferation (GO:2000179)3.72053418
45centriole assembly (GO:0098534)3.70261240
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.62041191
47auditory receptor cell stereocilium organization (GO:0060088)3.54705243
48respiratory chain complex IV assembly (GO:0008535)3.51814845
49regulation of water loss via skin (GO:0033561)3.48124733
50positive regulation of DNA-dependent DNA replication (GO:2000105)3.43872549
51muscle atrophy (GO:0014889)3.40153754
52positive regulation of mitochondrial fission (GO:0090141)3.38729801
53positive regulation of epidermis development (GO:0045684)3.38092600
54RNA localization (GO:0006403)3.37293666
55purine deoxyribonucleotide catabolic process (GO:0009155)3.35886008
56epithelial cell maturation (GO:0002070)3.35806422
57positive regulation of interleukin-1 beta production (GO:0032731)3.34718865
58cellular biogenic amine catabolic process (GO:0042402)3.33002237
59amine catabolic process (GO:0009310)3.33002237
60negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.30858442
61negative regulation of translation, ncRNA-mediated (GO:0040033)3.30858442
62regulation of translation, ncRNA-mediated (GO:0045974)3.30858442
63cell migration involved in gastrulation (GO:0042074)3.29203301
64negative regulation of monooxygenase activity (GO:0032769)3.27277805
65monoubiquitinated protein deubiquitination (GO:0035520)3.24439622
66negative regulation of DNA repair (GO:0045738)3.17041466
67behavioral response to nicotine (GO:0035095)3.16868003
68pseudouridine synthesis (GO:0001522)3.13237348
69cellular response to reactive nitrogen species (GO:1902170)3.11858233
70hair cycle process (GO:0022405)3.07039477
71molting cycle process (GO:0022404)3.07039477
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.05158649
73regulation of protein polyubiquitination (GO:1902914)2.96646803
74radial glial cell differentiation (GO:0060019)2.95523711
75pantothenate metabolic process (GO:0015939)2.94295726
76negative regulation of response to DNA damage stimulus (GO:2001021)2.94181820
77ribosomal small subunit biogenesis (GO:0042274)2.92989662
78positive regulation of interleukin-1 production (GO:0032732)2.88480397
79negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.86560101
80UTP biosynthetic process (GO:0006228)2.84577763
81positive regulation of CREB transcription factor activity (GO:0032793)2.83394445
82aromatic amino acid family catabolic process (GO:0009074)2.82831323
83regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229)2.82034765
84CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.80557254
85ATP synthesis coupled proton transport (GO:0015986)2.79439357
86energy coupled proton transport, down electrochemical gradient (GO:0015985)2.79439357
87inositol metabolic process (GO:0006020)2.79348905
88regulation of histone deacetylation (GO:0031063)2.77678422
89regulation of DNA-templated transcription, elongation (GO:0032784)2.77208969
90negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.76038540
91peristalsis (GO:0030432)2.72595830
92neuron remodeling (GO:0016322)2.71640829
93mitochondrial fusion (GO:0008053)2.70205831
94mitochondrion morphogenesis (GO:0070584)2.69914150
95negative regulation of translational initiation (GO:0045947)2.69630257
96formation of translation preinitiation complex (GO:0001731)2.68712571
97poly(A)+ mRNA export from nucleus (GO:0016973)2.66502353
98regulation of steroid hormone secretion (GO:2000831)2.65671330
99cytochrome complex assembly (GO:0017004)2.64222989
100snRNA transcription (GO:0009301)11.1237920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human5.23644312
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.26593659
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.35497673
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.18220553
5E2F7_22180533_ChIP-Seq_HELA_Human3.12997332
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90174446
7ESR1_15608294_ChIP-ChIP_MCF-7_Human2.87420985
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.83879710
9ZNF274_21170338_ChIP-Seq_K562_Hela2.80919351
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76950166
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59869682
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54266865
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.48722245
14TDRD3_21172665_ChIP-Seq_MCF-7_Human2.45497545
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42590969
16VDR_22108803_ChIP-Seq_LS180_Human2.36989768
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33721344
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.27463494
19IRF1_19129219_ChIP-ChIP_H3396_Human2.19109365
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.19097986
21VDR_23849224_ChIP-Seq_CD4+_Human2.15851634
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.09661629
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04500607
24HOXB4_20404135_ChIP-ChIP_EML_Mouse1.99080376
25DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.96197757
26CIITA_25753668_ChIP-Seq_RAJI_Human1.91629230
27GATA1_22025678_ChIP-Seq_K562_Human1.84900187
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.78793942
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77599034
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.72954338
31MYC_18940864_ChIP-ChIP_HL60_Human1.72877935
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68706001
33BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.68024979
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65364661
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.59272335
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54715053
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.53993205
38SOX2_16153702_ChIP-ChIP_HESCs_Human1.53725387
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52354885
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50776320
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48671585
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.47149065
43XRN2_22483619_ChIP-Seq_HELA_Human1.46869847
44ETV1_20927104_ChIP-Seq_GIST48_Human1.44718359
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40538968
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37177310
47ELK1_19687146_ChIP-ChIP_HELA_Human1.35489807
48SMAD1_18555785_Chip-Seq_ESCs_Mouse1.29768676
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28626353
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.25317721
51ZFX_18555785_Chip-Seq_ESCs_Mouse1.24370892
52P300_18555785_Chip-Seq_ESCs_Mouse1.22132436
53GATA6_21074721_ChIP-Seq_CACO-2_Human1.19509904
54CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19453186
55GABP_19822575_ChIP-Seq_HepG2_Human1.19059350
56CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18648980
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18222567
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16304855
59SCL_19346495_ChIP-Seq_HPC-7_Human1.15226150
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14809999
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.14640028
62PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.12564920
63AR_21572438_ChIP-Seq_LNCaP_Human1.11014640
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10916659
65FOXP3_21729870_ChIP-Seq_TREG_Human1.08956853
66RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08280639
67GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07607520
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07040993
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.04816117
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02783437
71IGF1R_20145208_ChIP-Seq_DFB_Human1.02614119
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01389173
73CHD1_26751641_Chip-Seq_LNCaP_Human0.99930240
74CTCF_21964334_Chip-Seq_Bcells_Human0.99642469
75NFE2_27457419_Chip-Seq_LIVER_Mouse0.99039571
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98774060
77PHF8_20622854_ChIP-Seq_HELA_Human0.98730700
78CBX2_22325352_ChIP-Seq_293T-Rex_Human0.98180573
79NANOG_16153702_ChIP-ChIP_HESCs_Human0.97847724
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95512905
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95213391
82PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94823981
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93150074
84ESR1_20079471_ChIP-ChIP_T-47D_Human0.92580430
85GATA1_26923725_Chip-Seq_HPCs_Mouse0.92411207
86TTF2_22483619_ChIP-Seq_HELA_Human0.92075394
87SOX2_18555785_Chip-Seq_ESCs_Mouse0.91916721
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91001810
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90697475
90CTCF_26484167_Chip-Seq_Bcells_Mouse0.90540794
91RBPJ_21746931_ChIP-Seq_IB4_Human0.89247003
92PHF8_20622853_ChIP-Seq_HELA_Human0.88817153
93FUS_26573619_Chip-Seq_HEK293_Human0.88519473
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88438232
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87810285
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.87756654
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87158156
98NFYA_21822215_ChIP-Seq_K562_Human0.87143206
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86376289
100CTCF_18555785_Chip-Seq_ESCs_Mouse0.85396200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005408_hypopigmentation6.73728104
2MP0000579_abnormal_nail_morphology4.46413773
3MP0001661_extended_life_span3.78351648
4MP0005275_abnormal_skin_tensile3.32451964
5MP0000427_abnormal_hair_cycle3.06366241
6MP0000383_abnormal_hair_follicle2.65418026
7MP0002098_abnormal_vibrissa_morphology2.62074869
8MP0005075_abnormal_melanosome_morpholog2.31469380
9MP0005451_abnormal_body_composition13.7828051
10MP0002837_dystrophic_cardiac_calcinosis1.92472788
11MP0002095_abnormal_skin_pigmentation1.84713913
12MP0004381_abnormal_hair_follicle1.82611636
13MP0002132_abnormal_respiratory_system1.76456573
14MP0010678_abnormal_skin_adnexa1.73792885
15MP0008260_abnormal_autophagy1.57654124
16MP0005083_abnormal_biliary_tract1.55312804
17MP0003950_abnormal_plasma_membrane1.52490798
18MP0010030_abnormal_orbit_morphology1.52268104
19MP0009384_cardiac_valve_regurgitation1.45114260
20MP0000647_abnormal_sebaceous_gland1.42700083
21MP0002938_white_spotting1.40439516
22MP0001348_abnormal_lacrimal_gland1.34607831
23MP0008995_early_reproductive_senescence1.33756432
24MP0000639_abnormal_adrenal_gland1.33265987
25MP0000631_abnormal_neuroendocrine_gland1.31896357
26MP0002638_abnormal_pupillary_reflex1.31701602
27MP0006035_abnormal_mitochondrial_morpho1.30780331
28MP0001186_pigmentation_phenotype1.30185862
29MP0003890_abnormal_embryonic-extraembry1.29822469
30MP0010094_abnormal_chromosome_stability1.27997410
31MP0004147_increased_porphyrin_level1.26369306
32MP0008877_abnormal_DNA_methylation1.20148765
33MP0000377_abnormal_hair_follicle1.18208386
34MP0003787_abnormal_imprinting1.16385491
35MP0003786_premature_aging1.10415036
36MP0001188_hyperpigmentation1.08145110
37MP0002075_abnormal_coat/hair_pigmentati1.07500277
38MP0006292_abnormal_olfactory_placode1.06517534
39MP0004742_abnormal_vestibular_system1.00224894
40MP0003693_abnormal_embryo_hatching0.99859002
41MP0000367_abnormal_coat/_hair0.95196344
42MP0002254_reproductive_system_inflammat0.93041322
43MP0002138_abnormal_hepatobiliary_system0.91083271
44MP0001849_ear_inflammation0.86487194
45MP0004264_abnormal_extraembryonic_tissu0.85439932
46MP0002282_abnormal_trachea_morphology0.84917455
47MP0006036_abnormal_mitochondrial_physio0.84179661
48MP0005171_absent_coat_pigmentation0.82972353
49MP0009703_decreased_birth_body0.81445852
50MP0004957_abnormal_blastocyst_morpholog0.81407835
51MP0005084_abnormal_gallbladder_morpholo0.77467980
52MP0001243_abnormal_dermal_layer0.75637480
53MP0002796_impaired_skin_barrier0.74201491
54MP0010352_gastrointestinal_tract_polyps0.71911051
55MP0001293_anophthalmia0.68901941
56MP0004947_skin_inflammation0.68556055
57MP0001881_abnormal_mammary_gland0.67323857
58MP0004084_abnormal_cardiac_muscle0.64321576
59MP0004858_abnormal_nervous_system0.63432027
60MP0005076_abnormal_cell_differentiation0.61587568
61MP0003172_abnormal_lysosome_physiology0.61194102
62MP0008932_abnormal_embryonic_tissue0.61110856
63MP0005645_abnormal_hypothalamus_physiol0.59943831
64MP0005551_abnormal_eye_electrophysiolog0.59604681
65MP0009931_abnormal_skin_appearance0.57282263
66MP0004808_abnormal_hematopoietic_stem0.57038126
67MP0000358_abnormal_cell_content/0.55840623
68MP0001730_embryonic_growth_arrest0.55361611
69MP0003111_abnormal_nucleus_morphology0.54559692
70MP0001191_abnormal_skin_condition0.53556700
71MP0003806_abnormal_nucleotide_metabolis0.53347054
72MP0002970_abnormal_white_adipose0.53211002
73MP0002405_respiratory_system_inflammati0.52910380
74MP0003656_abnormal_erythrocyte_physiolo0.49286932
75MP0000350_abnormal_cell_proliferation0.49196388
76MP0001216_abnormal_epidermal_layer0.47693379
77MP0002088_abnormal_embryonic_growth/wei0.45515806
78MP0003984_embryonic_growth_retardation0.44751788
79MP0005670_abnormal_white_adipose0.43328290
80MP0001697_abnormal_embryo_size0.43120196
81MP0008770_decreased_survivor_rate0.42803715
82MP0000627_abnormal_mammary_gland0.39188193
83MP0002697_abnormal_eye_size0.38916134
84MP0005266_abnormal_metabolism0.38631351
85MP0005380_embryogenesis_phenotype0.37848534
86MP0001672_abnormal_embryogenesis/_devel0.37848534
87MP0001919_abnormal_reproductive_system0.36921652
88MP0002295_abnormal_pulmonary_circulatio0.35772231
89MP0005174_abnormal_tail_pigmentation0.35704556
90MP0000372_irregular_coat_pigmentation0.35385914
91MP0002396_abnormal_hematopoietic_system0.35371362
92MP0008058_abnormal_DNA_repair0.35093374
93MP0009379_abnormal_foot_pigmentation0.34334399
94MP0003077_abnormal_cell_cycle0.33963028
95MP0005501_abnormal_skin_physiology0.33868053
96MP0003121_genomic_imprinting0.33642552
97MP0001545_abnormal_hematopoietic_system0.32296324
98MP0005397_hematopoietic_system_phenotyp0.32296324
99MP0001119_abnormal_female_reproductive0.29498060
100MP0010771_integument_phenotype0.28816052

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)8.54046964
2Congenital, generalized hypertrichosis (HP:0004540)6.86050122
3Adrenal hypoplasia (HP:0000835)6.71315247
4Abnormal hair laboratory examination (HP:0003328)6.68153061
5Sparse lateral eyebrow (HP:0005338)5.61814760
6Slow-growing hair (HP:0002217)5.55053882
7Abnormality of hair growth rate (HP:0011363)5.55053882
8Woolly hair (HP:0002224)5.15325336
9Sparse eyelashes (HP:0000653)4.71826870
10Intrahepatic cholestasis (HP:0001406)4.33196647
11Concave nail (HP:0001598)3.96136814
12Degeneration of anterior horn cells (HP:0002398)3.71617120
13Abnormality of the anterior horn cell (HP:0006802)3.71617120
14Birth length less than 3rd percentile (HP:0003561)3.64477839
15Right ventricular cardiomyopathy (HP:0011663)3.62118334
16Brittle hair (HP:0002299)3.55776287
17Abnormality of homocysteine metabolism (HP:0010919)3.18490299
18Homocystinuria (HP:0002156)3.18490299
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.12295663
20Tubulointerstitial nephritis (HP:0001970)3.11241736
21Flat capital femoral epiphysis (HP:0003370)3.09603156
22Deep philtrum (HP:0002002)2.90143726
23Infantile muscular hypotonia (HP:0008947)2.79928327
24Anhidrosis (HP:0000970)2.78689671
25Morphological abnormality of the inner ear (HP:0011390)2.76241471
26Amyloidosis (HP:0011034)2.75963799
27Abnormal rod and cone electroretinograms (HP:0008323)2.72940283
28Conjugated hyperbilirubinemia (HP:0002908)2.67497120
29Abnormality of the preputium (HP:0100587)2.48609072
30Hypoparathyroidism (HP:0000829)2.46768069
31Abnormality of lateral ventricle (HP:0030047)2.46295825
32Long clavicles (HP:0000890)2.42127611
33Increased hepatocellular lipid droplets (HP:0006565)2.41914536
34Abnormality of midbrain morphology (HP:0002418)2.41717466
35Molar tooth sign on MRI (HP:0002419)2.41717466
36Abnormality of the proximal phalanges of the hand (HP:0009834)2.39626882
37Spastic paraparesis (HP:0002313)2.36622844
38Methylmalonic acidemia (HP:0002912)2.35847401
39Testicular atrophy (HP:0000029)2.31922705
40Symptomatic seizures (HP:0011145)2.28753417
41Fine hair (HP:0002213)2.26994522
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21589533
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21280599
44Tetany (HP:0001281)2.20444635
45Porencephaly (HP:0002132)2.16383004
46Attenuation of retinal blood vessels (HP:0007843)2.15434111
47Erythema (HP:0010783)2.13671800
48Volvulus (HP:0002580)2.09546571
49Decreased central vision (HP:0007663)2.08791850
50Abnormality of vitamin metabolism (HP:0100508)2.07422340
51Thickened nuchal skin fold (HP:0000474)2.07327933
52Curly hair (HP:0002212)2.07045978
53Petechiae (HP:0000967)2.06178073
54Cerebral hypomyelination (HP:0006808)2.04999532
55Lipid accumulation in hepatocytes (HP:0006561)2.03775237
56Congenital stationary night blindness (HP:0007642)2.02826634
57Sensory axonal neuropathy (HP:0003390)2.02699717
58Hyperacusis (HP:0010780)2.02047087
59Methylmalonic aciduria (HP:0012120)2.01163761
60Pili torti (HP:0003777)11.3099806
61Myokymia (HP:0002411)1.99673774
62Steatorrhea (HP:0002570)1.99488514
63Horizontal nystagmus (HP:0000666)1.98996806
64CNS hypomyelination (HP:0003429)1.97439939
65Hypotrichosis (HP:0001006)1.95807788
66Syncope (HP:0001279)1.94672142
67Deep palmar crease (HP:0006191)1.91465403
68Abnormality of cochlea (HP:0000375)1.86998538
69Hypoplasia of the pons (HP:0012110)1.86947717
70Protruding tongue (HP:0010808)1.85844580
71Renal Fanconi syndrome (HP:0001994)1.85357887
72Cellular immunodeficiency (HP:0005374)1.84324650
73Chronic sinusitis (HP:0011109)1.81725520
74Respiratory difficulties (HP:0002880)1.80577815
75Abnormality of nail color (HP:0100643)1.77948157
76Elfin facies (HP:0004428)1.77020275
77Microvesicular hepatic steatosis (HP:0001414)1.75439648
78Neoplasm of the oral cavity (HP:0100649)1.74923271
79Horseshoe kidney (HP:0000085)1.74771911
80Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.74578463
81Down-sloping shoulders (HP:0200021)1.74482394
82Hypomagnesemia (HP:0002917)1.72002230
83Coarse hair (HP:0002208)1.71555794
84Oral leukoplakia (HP:0002745)1.69564826
85Overriding aorta (HP:0002623)1.68621469
86Abnormality of the pons (HP:0007361)1.68420344
87Hypophosphatemic rickets (HP:0004912)1.67578481
88Increased number of teeth (HP:0011069)1.64103166
89Abnormality of chromosome stability (HP:0003220)1.62313680
90Pruritus (HP:0000989)1.61375208
91Smooth philtrum (HP:0000319)1.61021160
92Spontaneous abortion (HP:0005268)1.60367638
93Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.59869812
94Abnormality of renal resorption (HP:0011038)1.59229656
95Pendular nystagmus (HP:0012043)1.59187049
96Abnormality of the gastric mucosa (HP:0004295)1.58302128
97Abnormality of methionine metabolism (HP:0010901)1.56464695
98Abnormality of dicarboxylic acid metabolism (HP:0010995)1.54792853
99Dicarboxylic aciduria (HP:0003215)1.54792853
100J-shaped sella turcica (HP:0002680)1.53181912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK15.37171992
2MAP2K35.26524431
3NME23.91801261
4CSNK1G13.23541578
5EPHA23.17497438
6EIF2AK13.16218769
7MAP2K43.13022479
8IRAK32.92892616
9MAP2K62.74105945
10IRAK22.37932700
11NME12.34725706
12CSNK1G32.30046279
13SRPK12.23068707
14CASK2.19066464
15CSNK1A1L2.15789948
16ZAK2.06344856
17PHKG11.98824301
18PHKG21.98824301
19VRK21.96853628
20CSNK1G21.89427827
21NEK21.76026366
22TNIK1.72483682
23TLK11.65299431
24MST1R1.62103121
25MST41.53471158
26PBK1.53339270
27EPHA31.40666656
28MAP3K41.38648995
29STK381.23140044
30CDK191.20190685
31DMPK1.09461823
32CHEK21.04282355
33PIM21.03359152
34NUAK10.99361781
35IRAK10.98575240
36VRK10.97932168
37MAP4K20.96857124
38PRKCI0.93936919
39TNK20.88198489
40CSNK1E0.87997856
41TAF10.87734975
42WNK30.86443000
43PRKCH0.84099985
44PRKAA10.83019376
45MAPK120.82098049
46SCYL20.75759512
47ERBB20.74089911
48ADRBK10.70398061
49MKNK20.62770980
50RAF10.60290447
51WEE10.59512013
52MAPK150.55880438
53AURKB0.55016757
54CDC70.54134552
55CDK70.51916850
56ACVR1B0.48618607
57MAP2K70.48529086
58STK30.48014080
59ATR0.47726483
60MAP3K60.45508826
61TTK0.41851647
62PRPF4B0.41328676
63NLK0.38735108
64TAOK20.37131896
65ATM0.36239853
66WNK10.36084311
67CSNK1A10.35877658
68CDK20.35723176
69LRRK20.35128179
70FES0.34864641
71ZAP700.34828404
72CSNK1D0.33668908
73CDK10.33620487
74PLK40.33571552
75AURKA0.33296935
76GSK3A0.32970055
77JAK20.29473486
78MAP3K100.28915564
79DAPK30.28585342
80MAP3K20.27760789
81NEK10.27426737
82CSNK2A10.27316969
83DAPK20.26675828
84HCK0.26616327
85CSNK2A20.26365532
86MAPK130.26045003
87MET0.26033043
88PDGFRB0.25999780
89BMPR1B0.25270272
90PRKD20.25065044
91PIM10.24865160
92GSK3B0.23962070
93TEC0.22232028
94MAPK140.21859242
95IKBKE0.21651305
96CHEK10.20831347
97PRKDC0.19924962
98MAP3K90.19138562
99RPS6KA50.18400013
100ADRBK20.18261814

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.76585943
2RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.38117305
3NOD-like receptor signaling pathway_Homo sapiens_hsa046213.35828720
4Thyroid cancer_Homo sapiens_hsa052163.03939761
5Phototransduction_Homo sapiens_hsa047442.95675228
6Ribosome_Homo sapiens_hsa030102.75534022
7Selenocompound metabolism_Homo sapiens_hsa004502.58210598
8Mismatch repair_Homo sapiens_hsa034302.37067789
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34106072
10Sulfur metabolism_Homo sapiens_hsa009202.32690092
11Basal transcription factors_Homo sapiens_hsa030222.31134604
12Tryptophan metabolism_Homo sapiens_hsa003802.28453290
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.17381164
14Non-homologous end-joining_Homo sapiens_hsa034502.10023158
15Spliceosome_Homo sapiens_hsa030402.04096342
16Homologous recombination_Homo sapiens_hsa034401.94296489
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.85035338
18Proteasome_Homo sapiens_hsa030501.84780664
19Sulfur relay system_Homo sapiens_hsa041221.83913423
20RNA polymerase_Homo sapiens_hsa030201.83567145
21Fanconi anemia pathway_Homo sapiens_hsa034601.81096118
22Notch signaling pathway_Homo sapiens_hsa043301.79922452
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.72876306
24RNA transport_Homo sapiens_hsa030131.70691141
25Oxidative phosphorylation_Homo sapiens_hsa001901.66072394
26Pyrimidine metabolism_Homo sapiens_hsa002401.64837644
27Bladder cancer_Homo sapiens_hsa052191.58537818
28RNA degradation_Homo sapiens_hsa030181.46550248
29DNA replication_Homo sapiens_hsa030301.41346880
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39717686
31Huntingtons disease_Homo sapiens_hsa050161.30938371
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29045703
33Ovarian steroidogenesis_Homo sapiens_hsa049131.24204555
34mRNA surveillance pathway_Homo sapiens_hsa030151.19932324
35Parkinsons disease_Homo sapiens_hsa050121.11379951
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10989747
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.10262887
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09562769
39Purine metabolism_Homo sapiens_hsa002301.02449610
40Alzheimers disease_Homo sapiens_hsa050101.02187626
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99281014
42TNF signaling pathway_Homo sapiens_hsa046680.98889096
43Axon guidance_Homo sapiens_hsa043600.97697750
44Nicotine addiction_Homo sapiens_hsa050330.94679851
45Chemical carcinogenesis_Homo sapiens_hsa052040.91669017
46Hepatitis C_Homo sapiens_hsa051600.89296862
47Steroid biosynthesis_Homo sapiens_hsa001000.88062377
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87989470
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85593346
50Prolactin signaling pathway_Homo sapiens_hsa049170.84871226
51ABC transporters_Homo sapiens_hsa020100.84865986
52Lysine degradation_Homo sapiens_hsa003100.79208067
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77906912
54Inositol phosphate metabolism_Homo sapiens_hsa005620.75733176
55Collecting duct acid secretion_Homo sapiens_hsa049660.75586478
56Influenza A_Homo sapiens_hsa051640.74422965
57Systemic lupus erythematosus_Homo sapiens_hsa053220.73562084
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70054346
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68497219
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67217462
61Nitrogen metabolism_Homo sapiens_hsa009100.64540028
62Small cell lung cancer_Homo sapiens_hsa052220.62503697
63Herpes simplex infection_Homo sapiens_hsa051680.62276593
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61462013
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.60845492
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.60678308
67Acute myeloid leukemia_Homo sapiens_hsa052210.57166907
68Colorectal cancer_Homo sapiens_hsa052100.55699574
69Vitamin digestion and absorption_Homo sapiens_hsa049770.55435830
70One carbon pool by folate_Homo sapiens_hsa006700.52821048
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52638206
72Taste transduction_Homo sapiens_hsa047420.52069986
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51237577
74Hepatitis B_Homo sapiens_hsa051610.50788586
75Propanoate metabolism_Homo sapiens_hsa006400.48164456
76Peroxisome_Homo sapiens_hsa041460.46520976
77GnRH signaling pathway_Homo sapiens_hsa049120.44231176
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42413752
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41871152
80Vibrio cholerae infection_Homo sapiens_hsa051100.41657456
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.39032047
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37846697
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.36551905
84Chronic myeloid leukemia_Homo sapiens_hsa052200.36119100
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35849638
86Cell cycle_Homo sapiens_hsa041100.35566956
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34277029
88Non-small cell lung cancer_Homo sapiens_hsa052230.31751723
89Alcoholism_Homo sapiens_hsa050340.31369585
90Basal cell carcinoma_Homo sapiens_hsa052170.29186371
91Cardiac muscle contraction_Homo sapiens_hsa042600.28847581
92Epstein-Barr virus infection_Homo sapiens_hsa051690.28377457
93Metabolic pathways_Homo sapiens_hsa011000.26671087
94Legionellosis_Homo sapiens_hsa051340.24385851
95Galactose metabolism_Homo sapiens_hsa000520.20309004
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16053539
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15499065
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.14914654
99VEGF signaling pathway_Homo sapiens_hsa043700.14711239
100Oocyte meiosis_Homo sapiens_hsa041140.14599605

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