HSPA8P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)5.90150812
2DNA deamination (GO:0045006)5.23721416
3protein neddylation (GO:0045116)4.98845377
4rRNA modification (GO:0000154)4.85194679
5rRNA methylation (GO:0031167)4.69763185
6cellular response to interleukin-15 (GO:0071350)4.66271904
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.53134230
8positive regulation of immune response to tumor cell (GO:0002839)4.41305311
9regulation of immune response to tumor cell (GO:0002837)4.41305311
10regulation of response to tumor cell (GO:0002834)4.41305311
11positive regulation of response to tumor cell (GO:0002836)4.41305311
12regulation of immunoglobulin secretion (GO:0051023)4.39249359
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.36715107
14respiratory chain complex IV assembly (GO:0008535)4.10089902
15chaperone-mediated protein transport (GO:0072321)3.97178424
16ATP synthesis coupled proton transport (GO:0015986)3.95528850
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.95528850
18DNA double-strand break processing (GO:0000729)3.92616091
19cytidine deamination (GO:0009972)3.88232290
20cytidine metabolic process (GO:0046087)3.88232290
21cytidine catabolic process (GO:0006216)3.88232290
22regulation of cellular amino acid metabolic process (GO:0006521)3.79492801
23pseudouridine synthesis (GO:0001522)3.78363160
24regulation of isotype switching to IgG isotypes (GO:0048302)3.76220077
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.70334306
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.70334306
27response to interleukin-15 (GO:0070672)3.70325712
28cullin deneddylation (GO:0010388)3.61545349
29negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.55466442
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50490913
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.48112620
32NADH dehydrogenase complex assembly (GO:0010257)3.48112620
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48112620
34CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.46535848
35positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.40291307
36protein deneddylation (GO:0000338)3.37961343
37positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.36856101
38peptidyl-histidine modification (GO:0018202)3.36521240
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.36460862
40maturation of 5.8S rRNA (GO:0000460)3.34633180
41positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.34019523
42interferon-gamma production (GO:0032609)3.30878715
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26575922
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26575922
45response to redox state (GO:0051775)3.25915167
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.25850701
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.25850701
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.25850701
49positive regulation of T cell mediated cytotoxicity (GO:0001916)3.25561706
50pyrimidine ribonucleoside catabolic process (GO:0046133)3.19776753
51positive regulation of osteoclast differentiation (GO:0045672)3.18980262
52protein complex biogenesis (GO:0070271)3.16103249
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.15942946
54regulation of T cell chemotaxis (GO:0010819)3.14039648
55positive regulation of T cell chemotaxis (GO:0010820)3.14039648
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.13697249
57proteasome assembly (GO:0043248)3.13413839
58positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.13285589
59negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12782922
60negative regulation of ligase activity (GO:0051352)3.12782922
61positive regulation of T cell cytokine production (GO:0002726)3.12611707
62negative regulation of heart rate (GO:0010459)3.08989554
63rRNA catabolic process (GO:0016075)3.08957233
64positive regulation of natural killer cell mediated immunity (GO:0002717)3.07774719
65regulation of leukocyte mediated cytotoxicity (GO:0001910)3.05768146
66mitochondrial RNA metabolic process (GO:0000959)3.05477807
67signal transduction involved in DNA integrity checkpoint (GO:0072401)3.05234658
68signal transduction involved in DNA damage checkpoint (GO:0072422)3.05234658
69regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.04605583
70protein localization to cilium (GO:0061512)3.04195068
71negative regulation of T-helper cell differentiation (GO:0045623)3.03655278
72negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03655278
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01909797
74hepatocyte apoptotic process (GO:0097284)3.01707140
75negative regulation of calcium ion transport into cytosol (GO:0010523)2.99884293
76signal transduction involved in cell cycle checkpoint (GO:0072395)2.99723834
77regulation of regulatory T cell differentiation (GO:0045589)2.99632668
78mitochondrial respiratory chain complex assembly (GO:0033108)2.98496709
79antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.93149049
80tRNA processing (GO:0008033)2.91226719
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.89690727
82regulation of T cell mediated cytotoxicity (GO:0001914)2.89268417
83positive regulation of lymphocyte mediated immunity (GO:0002708)2.88798270
84positive regulation of T cell mediated immunity (GO:0002711)2.88618002
85cellular response to interferon-beta (GO:0035458)2.88050675
86positive regulation of cell killing (GO:0031343)2.87452507
87behavioral response to nicotine (GO:0035095)2.87421323
88activated T cell proliferation (GO:0050798)2.86287810
89termination of RNA polymerase III transcription (GO:0006386)2.84010189
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.84010189
91positive regulation of immunoglobulin production (GO:0002639)2.83235775
92tRNA metabolic process (GO:0006399)2.82717985
93signal peptide processing (GO:0006465)2.82186667
94protein-cofactor linkage (GO:0018065)2.79168030
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78773309
96positive regulation of immunoglobulin mediated immune response (GO:0002891)2.78534859
97positive regulation of B cell mediated immunity (GO:0002714)2.78534859
98transcription elongation from RNA polymerase I promoter (GO:0006362)2.77988266
99protein refolding (GO:0042026)2.75792595
100hydrogen ion transmembrane transport (GO:1902600)2.75001353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.18031970
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12851872
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.58354899
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.35369568
5FLI1_27457419_Chip-Seq_LIVER_Mouse3.03220776
6VDR_22108803_ChIP-Seq_LS180_Human2.96852547
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.85073146
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59556418
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.57056795
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52027392
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39885002
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37153811
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33788025
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.30087858
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.27314607
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27224698
17ELK1_19687146_ChIP-ChIP_HELA_Human2.22242245
18VDR_23849224_ChIP-Seq_CD4+_Human2.15824427
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08702984
20SUZ12_27294783_Chip-Seq_NPCs_Mouse2.03045860
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.98301312
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.95947176
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95768488
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87468589
25ZNF274_21170338_ChIP-Seq_K562_Hela1.87260775
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85099471
27EWS_26573619_Chip-Seq_HEK293_Human1.83552123
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.79596565
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.78645576
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70331210
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.62825488
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61626768
33TP53_22573176_ChIP-Seq_HFKS_Human1.58737256
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58062501
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50125659
36P300_19829295_ChIP-Seq_ESCs_Human1.48793601
37EZH2_22144423_ChIP-Seq_EOC_Human1.46595014
38TAF15_26573619_Chip-Seq_HEK293_Human1.46387556
39FOXP3_21729870_ChIP-Seq_TREG_Human1.45447407
40MYC_18940864_ChIP-ChIP_HL60_Human1.41163117
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.40434238
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40434238
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39280749
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38912240
45FUS_26573619_Chip-Seq_HEK293_Human1.37696189
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.36738763
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35671459
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33992810
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31401714
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.30887622
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30242983
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29372832
53NANOG_19829295_ChIP-Seq_ESCs_Human1.27715925
54SOX2_19829295_ChIP-Seq_ESCs_Human1.27715925
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.26622075
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24926648
57GATA3_26560356_Chip-Seq_TH2_Human1.24344518
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23877152
59DCP1A_22483619_ChIP-Seq_HELA_Human1.23060168
60STAT3_18555785_Chip-Seq_ESCs_Mouse1.22051671
61PRDM14_20953172_ChIP-Seq_ESCs_Human1.21743985
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21069882
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.21013911
64SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.21003506
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17656288
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17385890
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15948862
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15889025
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15224344
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14643495
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13633545
72OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13439730
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.13208221
74OCT4_18555785_Chip-Seq_ESCs_Mouse1.11180740
75P300_18555785_Chip-Seq_ESCs_Mouse1.10934860
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10781417
77ER_23166858_ChIP-Seq_MCF-7_Human1.10571795
78P53_22387025_ChIP-Seq_ESCs_Mouse1.10180130
79FOXH1_21741376_ChIP-Seq_EPCs_Human1.09775043
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.09298837
81RUNX_20019798_ChIP-Seq_JUKART_Human1.08817308
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07579989
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06962384
84EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06777088
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.06730281
86IGF1R_20145208_ChIP-Seq_DFB_Human1.04099419
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02659879
88SOX2_18555785_Chip-Seq_ESCs_Mouse1.02428631
89GBX2_23144817_ChIP-Seq_PC3_Human1.02254401
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.02193719
91HTT_18923047_ChIP-ChIP_STHdh_Human1.01793668
92MYC_18555785_ChIP-Seq_MESCs_Mouse0.99807320
93SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98807645
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96646446
95HOXB7_26014856_ChIP-Seq_BT474_Human0.95651067
96E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95298544
97RBPJ_21746931_ChIP-Seq_IB4_Human0.94808245
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94326826
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94186210
100TCF4_22108803_ChIP-Seq_LS180_Human0.93860665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland4.54662662
2MP0005671_abnormal_response_to3.44121293
3MP0002163_abnormal_gland_morphology3.18519054
4MP0003646_muscle_fatigue3.01584394
5MP0000685_abnormal_immune_system2.94184418
6MP0001835_abnormal_antigen_presentation2.84110492
7MP0008872_abnormal_physiological_respon2.84101404
8MP0004147_increased_porphyrin_level2.75922273
9MP0005387_immune_system_phenotype2.37242440
10MP0001790_abnormal_immune_system2.37242440
11MP0008875_abnormal_xenobiotic_pharmacok2.30422853
12MP0009785_altered_susceptibility_to2.21437764
13MP0002102_abnormal_ear_morphology2.19211168
14MP0001873_stomach_inflammation2.11898251
15MP0004145_abnormal_muscle_electrophysio2.11118849
16MP0005379_endocrine/exocrine_gland_phen2.09180399
17MP0003436_decreased_susceptibility_to2.08369394
18MP0002006_tumorigenesis2.00869864
19MP0002876_abnormal_thyroid_physiology2.00826312
20MP0002148_abnormal_hypersensitivity_rea1.93444717
21MP0001800_abnormal_humoral_immune1.83740244
22MP0002138_abnormal_hepatobiliary_system1.81545485
23MP0002166_altered_tumor_susceptibility1.81323458
24MP0005645_abnormal_hypothalamus_physiol1.79205408
25MP0006072_abnormal_retinal_apoptosis1.75997233
26MP0004142_abnormal_muscle_tone1.74289764
27MP0005000_abnormal_immune_tolerance1.71214917
28MP0002254_reproductive_system_inflammat1.63344470
29MP0009333_abnormal_splenocyte_physiolog1.62428611
30MP0001501_abnormal_sleep_pattern1.59296202
31MP0003786_premature_aging1.55080408
32MP0003866_abnormal_defecation1.50262384
33MP0006054_spinal_hemorrhage1.50087619
34MP0003880_abnormal_central_pattern1.46036143
35MP0002272_abnormal_nervous_system1.41527628
36MP0002723_abnormal_immune_serum1.36813919
37MP0005310_abnormal_salivary_gland1.34165602
38MP0001905_abnormal_dopamine_level1.30347050
39MP0001968_abnormal_touch/_nociception1.27253814
40MP0008877_abnormal_DNA_methylation1.25278987
41MP0009046_muscle_twitch1.24140224
42MP0005084_abnormal_gallbladder_morpholo1.23261922
43MP0003724_increased_susceptibility_to1.22083976
44MP0003718_maternal_effect1.21768178
45MP0003763_abnormal_thymus_physiology1.21324217
46MP0009745_abnormal_behavioral_response1.20345473
47MP0002452_abnormal_antigen_presenting1.20045652
48MP0005551_abnormal_eye_electrophysiolog1.19522836
49MP0001440_abnormal_grooming_behavior1.17396265
50MP0009764_decreased_sensitivity_to1.17160360
51MP0004742_abnormal_vestibular_system1.15644111
52MP0001986_abnormal_taste_sensitivity1.14322414
53MP0000372_irregular_coat_pigmentation1.14232750
54MP0003186_abnormal_redox_activity1.12566218
55MP0005377_hearing/vestibular/ear_phenot1.11901646
56MP0003878_abnormal_ear_physiology1.11901646
57MP0002420_abnormal_adaptive_immunity1.11354086
58MP0010155_abnormal_intestine_physiology1.10757663
59MP0001919_abnormal_reproductive_system1.10739603
60MP0001819_abnormal_immune_cell1.10576582
61MP0001765_abnormal_ion_homeostasis1.09599597
62MP0001502_abnormal_circadian_rhythm1.09382090
63MP0003011_delayed_dark_adaptation1.06555630
64MP0005389_reproductive_system_phenotype1.05936072
65MP0001542_abnormal_bone_strength1.05847577
66MP0002735_abnormal_chemical_nociception1.02421642
67MP0005636_abnormal_mineral_homeostasis1.02334635
68MP0010386_abnormal_urinary_bladder1.01236660
69MP0005025_abnormal_response_to0.99730717
70MP0002736_abnormal_nociception_after0.99669891
71MP0001533_abnormal_skeleton_physiology0.99308381
72MP0001188_hyperpigmentation0.99016608
73MP0008438_abnormal_cutaneous_collagen0.98532001
74MP0002405_respiratory_system_inflammati0.97771316
75MP0002933_joint_inflammation0.96859419
76MP0005165_increased_susceptibility_to0.93050776
77MP0005187_abnormal_penis_morphology0.92714897
78MP0001845_abnormal_inflammatory_respons0.92619406
79MP0005646_abnormal_pituitary_gland0.92047217
80MP0000465_gastrointestinal_hemorrhage0.90600917
81MP0005253_abnormal_eye_physiology0.90064246
82MP0005085_abnormal_gallbladder_physiolo0.88822060
83MP0002160_abnormal_reproductive_system0.85123728
84MP0002751_abnormal_autonomic_nervous0.83370212
85MP0000689_abnormal_spleen_morphology0.82243032
86MP0004084_abnormal_cardiac_muscle0.82191568
87MP0004957_abnormal_blastocyst_morpholog0.78600374
88MP0001984_abnormal_olfaction0.77612886
89MP0001243_abnormal_dermal_layer0.76973719
90MP0005584_abnormal_enzyme/coenzyme_acti0.76306817
91MP0005451_abnormal_body_composition0.75958926
92MP0000716_abnormal_immune_system0.73870047
93MP0002063_abnormal_learning/memory/cond0.73716077
94MP0004381_abnormal_hair_follicle0.72744144
95MP0002398_abnormal_bone_marrow0.72200974
96MP0000569_abnormal_digit_pigmentation0.71555021
97MP0008469_abnormal_protein_level0.68382498
98MP0004036_abnormal_muscle_relaxation0.68370589
99MP0000427_abnormal_hair_cycle0.68013890
100MP0006082_CNS_inflammation0.67214259

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)4.61145450
2Hyperalaninemia (HP:0003348)4.61145450
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.61145450
4IgG deficiency (HP:0004315)4.50657565
5Acute necrotizing encephalopathy (HP:0006965)4.20016793
6Increased hepatocellular lipid droplets (HP:0006565)3.97347510
7Increased CSF lactate (HP:0002490)3.97066305
8Mitochondrial inheritance (HP:0001427)3.90728236
9Stomatitis (HP:0010280)3.76889977
10Hepatocellular necrosis (HP:0001404)3.71760687
11Lipid accumulation in hepatocytes (HP:0006561)3.56381395
12Abnormal mitochondria in muscle tissue (HP:0008316)3.53087901
13Progressive macrocephaly (HP:0004481)3.51119077
14Acute encephalopathy (HP:0006846)3.46898589
15Increased serum lactate (HP:0002151)3.36988113
163-Methylglutaconic aciduria (HP:0003535)3.29987329
17Hypoproteinemia (HP:0003075)3.27772854
18Increased intramyocellular lipid droplets (HP:0012240)2.98160759
19Hepatic necrosis (HP:0002605)2.91440255
20Progressive inability to walk (HP:0002505)2.88768668
21Chronic mucocutaneous candidiasis (HP:0002728)2.80246536
22Recurrent cutaneous fungal infections (HP:0011370)2.80246536
23Renal Fanconi syndrome (HP:0001994)2.75639902
24Congenital stationary night blindness (HP:0007642)2.73763414
25Exertional dyspnea (HP:0002875)2.72180971
26Aplasia/Hypoplasia of the fovea (HP:0008060)2.72166364
27Hypoplasia of the fovea (HP:0007750)2.72166364
28Abnormality of the anterior horn cell (HP:0006802)2.66029956
29Degeneration of anterior horn cells (HP:0002398)2.66029956
30Decreased electroretinogram (ERG) amplitude (HP:0000654)2.64727164
31Optic disc pallor (HP:0000543)2.64371333
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63109736
33Aplastic anemia (HP:0001915)2.62263934
34Abnormality of the labia minora (HP:0012880)2.60434952
35Pancreatic cysts (HP:0001737)2.56776905
36Pendular nystagmus (HP:0012043)2.56283525
37Renal cortical cysts (HP:0000803)2.54675015
38Tongue fasciculations (HP:0001308)2.49447632
39Increased IgM level (HP:0003496)2.42573099
40Agitation (HP:0000713)2.42202006
41Abnormality of the pons (HP:0007361)2.42194255
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.41193746
43Leukodystrophy (HP:0002415)2.40984777
44Abnormality of T cell physiology (HP:0011840)2.38362883
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.36066552
46Hypoplasia of the pons (HP:0012110)2.35311129
47Inability to walk (HP:0002540)2.34450725
48Abnormality of T cells (HP:0002843)2.34298396
49Constricted visual fields (HP:0001133)2.33880351
50Abnormality of T cell number (HP:0011839)2.33528015
51Increased muscle lipid content (HP:0009058)2.31246336
52Increased corneal curvature (HP:0100692)2.30387676
53Keratoconus (HP:0000563)2.30387676
54Bilateral microphthalmos (HP:0007633)2.28450539
55Abnormality of eosinophils (HP:0001879)2.23617855
56Methylmalonic acidemia (HP:0002912)2.22231304
57Lactic acidosis (HP:0003128)2.20683909
58Chorioretinal atrophy (HP:0000533)2.20265986
59B lymphocytopenia (HP:0010976)2.20238237
60Pulmonary infiltrates (HP:0002113)2.17427918
61Muscle fibrillation (HP:0010546)2.15723106
62Cerebral edema (HP:0002181)2.12744626
63Severe combined immunodeficiency (HP:0004430)2.09743706
64Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.07141119
65Fibular aplasia (HP:0002990)2.06081618
66Fatigue (HP:0012378)2.05585544
67Eosinophilia (HP:0001880)2.05293391
68Congenital, generalized hypertrichosis (HP:0004540)2.05243638
69Recurrent bronchitis (HP:0002837)2.03289932
70Type II lissencephaly (HP:0007260)2.02423257
71T lymphocytopenia (HP:0005403)2.01949865
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.00007720
73Joint swelling (HP:0001386)1.99288167
74Abnormality of the renal cortex (HP:0011035)1.99266240
75Carpal bone hypoplasia (HP:0001498)1.98641033
76Fair hair (HP:0002286)1.97750349
77Respiratory failure (HP:0002878)1.96757076
78Retrobulbar optic neuritis (HP:0100654)1.96385172
79Optic neuritis (HP:0100653)1.96385172
80Mutism (HP:0002300)1.95392627
81Abnormality of the fovea (HP:0000493)1.95062311
82Short tibia (HP:0005736)1.94896620
83Exercise intolerance (HP:0003546)1.94880392
84Aplasia/Hypoplasia of the ulna (HP:0006495)1.94246432
85Pancytopenia (HP:0001876)1.89576796
86Methylmalonic aciduria (HP:0012120)1.88343367
87Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.86009484
88Oral leukoplakia (HP:0002745)1.85087074
89Respiratory difficulties (HP:0002880)1.84164394
90Abnormality of B cell number (HP:0010975)1.82623096
91True hermaphroditism (HP:0010459)1.80198319
92Sensory axonal neuropathy (HP:0003390)1.79787229
93Thyroiditis (HP:0100646)1.79078202
94Aplasia/hypoplasia of the uterus (HP:0008684)1.78465900
95Aplasia/Hypoplasia of the macula (HP:0008059)1.75893812
96Hypokalemic alkalosis (HP:0001949)1.75205102
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74723717
98Keratoconjunctivitis (HP:0001096)1.74565913
99IgA deficiency (HP:0002720)1.74446388
100X-linked dominant inheritance (HP:0001423)1.73287494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK66.44678869
2MST43.29540787
3TXK3.20822264
4BUB12.92579366
5TAOK32.57660043
6WNK42.46756146
7MAP3K122.42597103
8TLK12.40917120
9NEK12.02591233
10STK391.98722906
11BCR1.89885413
12SIK31.87172362
13EIF2AK11.85960334
14SRPK11.84186568
15PBK1.71079171
16NUAK11.60472489
17TRIM281.59396656
18OXSR11.55223004
19PDK21.50933560
20AKT31.47579915
21ADRBK21.45324805
22EIF2AK31.42301729
23ZAK1.31981410
24MYLK1.31654567
25GRK11.22200830
26CASK1.21526064
27FES1.14990213
28DYRK21.14018782
29BMPR21.12101055
30MAP3K141.09910726
31PIK3CG1.09431615
32JAK11.06483931
33EPHA31.01986042
34PLK31.00195883
35ALK0.99864243
36CDK190.93780425
37MAP4K20.93091455
38JAK30.92795931
39DAPK10.90045103
40MARK30.88816767
41VRK20.87497093
42SGK20.87140529
43IKBKB0.85042516
44PINK10.83339952
45STK38L0.80696799
46TESK10.79882297
47PHKG20.79302563
48PHKG10.79302563
49TAF10.77777372
50WNK10.76921100
51IKBKE0.74906636
52DYRK30.74374060
53EIF2AK20.72289444
54TIE10.71744413
55SCYL20.71398656
56MINK10.67505709
57CSNK1A1L0.66996078
58RPS6KA40.65109770
59VRK10.64535607
60CSNK1G30.62876385
61PAK30.60779964
62INSRR0.59559500
63TGFBR20.59399655
64NME10.59129092
65GRK60.58757617
66SGK2230.57352471
67SGK4940.57352471
68KIT0.55071169
69MAP2K60.55010349
70MAP4K10.53961010
71STK240.53703212
72CSNK1G20.53124230
73CSNK1G10.51776426
74MAPK120.50269678
75CAMK2A0.50093822
76STK40.49839976
77MARK10.49047378
78LCK0.48350950
79FRK0.46500294
80LIMK10.45402587
81PRKCE0.43337156
82MAPKAPK30.42919214
83TEC0.41882164
84SGK30.41706033
85PLK20.41308883
86MKNK20.39344941
87PAK40.39217062
88DAPK20.38869209
89MUSK0.36350349
90PRKCQ0.35538179
91IGF1R0.34737795
92OBSCN0.34518630
93STK160.34508228
94STK100.33990766
95SYK0.29819551
96ATR0.29182748
97DAPK30.28987717
98GRK50.28673527
99PRKCG0.28621036
100CAMK2D0.28458610

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.88245183
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.71482890
3Oxidative phosphorylation_Homo sapiens_hsa001902.97047557
4Asthma_Homo sapiens_hsa053102.83670612
5Allograft rejection_Homo sapiens_hsa053302.76665946
6Autoimmune thyroid disease_Homo sapiens_hsa053202.71202397
7RNA polymerase_Homo sapiens_hsa030202.55575265
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.49094378
9Protein export_Homo sapiens_hsa030602.48905105
10One carbon pool by folate_Homo sapiens_hsa006702.36725048
11Parkinsons disease_Homo sapiens_hsa050122.33287963
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.30195724
13Antigen processing and presentation_Homo sapiens_hsa046122.30146210
14Basal transcription factors_Homo sapiens_hsa030221.96019153
15Primary immunodeficiency_Homo sapiens_hsa053401.90372575
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89236401
17Type I diabetes mellitus_Homo sapiens_hsa049401.88969191
18Graft-versus-host disease_Homo sapiens_hsa053321.87505469
19Sulfur metabolism_Homo sapiens_hsa009201.85813713
20Caffeine metabolism_Homo sapiens_hsa002321.80492911
21Nitrogen metabolism_Homo sapiens_hsa009101.76542435
22Collecting duct acid secretion_Homo sapiens_hsa049661.69473349
23Non-homologous end-joining_Homo sapiens_hsa034501.67105076
24Alzheimers disease_Homo sapiens_hsa050101.51965602
25Phototransduction_Homo sapiens_hsa047441.46499898
26Huntingtons disease_Homo sapiens_hsa050161.41121199
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39235033
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37228563
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35314333
30RNA degradation_Homo sapiens_hsa030181.34895971
31Rheumatoid arthritis_Homo sapiens_hsa053231.22913502
32RNA transport_Homo sapiens_hsa030131.21870551
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18689564
34Cardiac muscle contraction_Homo sapiens_hsa042601.18067080
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13340842
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.09482558
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08816467
38Hematopoietic cell lineage_Homo sapiens_hsa046401.07161560
39Measles_Homo sapiens_hsa051621.05528420
40Mismatch repair_Homo sapiens_hsa034301.00016422
41Ribosome_Homo sapiens_hsa030100.97779927
42Propanoate metabolism_Homo sapiens_hsa006400.90703295
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84050663
44T cell receptor signaling pathway_Homo sapiens_hsa046600.81372401
45Pyrimidine metabolism_Homo sapiens_hsa002400.80419131
46Purine metabolism_Homo sapiens_hsa002300.79707728
47Nicotine addiction_Homo sapiens_hsa050330.78118140
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77343713
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77196949
50Morphine addiction_Homo sapiens_hsa050320.76327287
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76125865
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72423181
53Vibrio cholerae infection_Homo sapiens_hsa051100.72263468
54Viral myocarditis_Homo sapiens_hsa054160.71285250
55Tryptophan metabolism_Homo sapiens_hsa003800.70193220
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65291284
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.63889073
58Nucleotide excision repair_Homo sapiens_hsa034200.63853725
59Epstein-Barr virus infection_Homo sapiens_hsa051690.62165752
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58073485
61Salivary secretion_Homo sapiens_hsa049700.54512175
62Olfactory transduction_Homo sapiens_hsa047400.54406674
63Homologous recombination_Homo sapiens_hsa034400.53737593
64Steroid biosynthesis_Homo sapiens_hsa001000.53611432
65Linoleic acid metabolism_Homo sapiens_hsa005910.51149805
66Synaptic vesicle cycle_Homo sapiens_hsa047210.48996291
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48278443
68GABAergic synapse_Homo sapiens_hsa047270.47517144
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.43393454
70Fat digestion and absorption_Homo sapiens_hsa049750.40048690
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39548619
72Spliceosome_Homo sapiens_hsa030400.39175040
73Peroxisome_Homo sapiens_hsa041460.38633560
74Metabolic pathways_Homo sapiens_hsa011000.35299234
75Pyruvate metabolism_Homo sapiens_hsa006200.34513948
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34217971
77Butanoate metabolism_Homo sapiens_hsa006500.33597277
78Glycerolipid metabolism_Homo sapiens_hsa005610.33134411
79Renin secretion_Homo sapiens_hsa049240.32871825
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32642131
81Insulin secretion_Homo sapiens_hsa049110.28042206
82Circadian entrainment_Homo sapiens_hsa047130.27201274
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27007260
84Chemical carcinogenesis_Homo sapiens_hsa052040.26741151
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25869033
86Taste transduction_Homo sapiens_hsa047420.25562141
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.25378654
88Selenocompound metabolism_Homo sapiens_hsa004500.23308593
89Circadian rhythm_Homo sapiens_hsa047100.22619278
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22477417
91Vitamin B6 metabolism_Homo sapiens_hsa007500.21956036
92Herpes simplex infection_Homo sapiens_hsa051680.21070609
93Pancreatic secretion_Homo sapiens_hsa049720.20862876
94Retinol metabolism_Homo sapiens_hsa008300.20278594
95Toxoplasmosis_Homo sapiens_hsa051450.16544321
96Arginine and proline metabolism_Homo sapiens_hsa003300.16500972
97Fanconi anemia pathway_Homo sapiens_hsa034600.14827730
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.14374422
99Phagosome_Homo sapiens_hsa041450.13893321
100Systemic lupus erythematosus_Homo sapiens_hsa053220.13809915

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