

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.15544651 |
| 2 | proteasome assembly (GO:0043248) | 4.61383223 |
| 3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.60036354 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 4.40389546 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.40389546 |
| 6 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.33432477 |
| 7 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.26712685 |
| 8 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.22763928 |
| 9 | rRNA modification (GO:0000154) | 4.20502972 |
| 10 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.19335153 |
| 11 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.09042664 |
| 12 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.02110839 |
| 13 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.00643240 |
| 14 | termination of RNA polymerase III transcription (GO:0006386) | 4.00643240 |
| 15 | chaperone-mediated protein transport (GO:0072321) | 3.94657128 |
| 16 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.92881388 |
| 17 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.92631614 |
| 18 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.92631614 |
| 19 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.92631614 |
| 20 | cytidine deamination (GO:0009972) | 3.90903886 |
| 21 | cytidine metabolic process (GO:0046087) | 3.90903886 |
| 22 | cytidine catabolic process (GO:0006216) | 3.90903886 |
| 23 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.89857408 |
| 24 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.89857408 |
| 25 | negative regulation of ligase activity (GO:0051352) | 3.89174589 |
| 26 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.89174589 |
| 27 | protein neddylation (GO:0045116) | 3.87145876 |
| 28 | cullin deneddylation (GO:0010388) | 3.86267182 |
| 29 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.81161538 |
| 30 | rRNA methylation (GO:0031167) | 3.80658821 |
| 31 | protein complex biogenesis (GO:0070271) | 3.79858801 |
| 32 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.78947632 |
| 33 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.76102252 |
| 34 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.76102252 |
| 35 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.72923078 |
| 36 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.71308730 |
| 37 | protein deneddylation (GO:0000338) | 3.64438838 |
| 38 | protein-cofactor linkage (GO:0018065) | 3.61333967 |
| 39 | DNA damage response, detection of DNA damage (GO:0042769) | 3.57719960 |
| 40 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.56602681 |
| 41 | NADH dehydrogenase complex assembly (GO:0010257) | 3.56602681 |
| 42 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.56602681 |
| 43 | DNA double-strand break processing (GO:0000729) | 3.56486096 |
| 44 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.53727966 |
| 45 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.53189013 |
| 46 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.52423934 |
| 47 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.49677363 |
| 48 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.48672624 |
| 49 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.47513295 |
| 50 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.47513295 |
| 51 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.42715164 |
| 52 | pseudouridine synthesis (GO:0001522) | 3.41922579 |
| 53 | respiratory chain complex IV assembly (GO:0008535) | 3.40233653 |
| 54 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.31017170 |
| 55 | respiratory electron transport chain (GO:0022904) | 3.29582968 |
| 56 | electron transport chain (GO:0022900) | 3.28194202 |
| 57 | maturation of 5.8S rRNA (GO:0000460) | 3.27608463 |
| 58 | regulation of chronic inflammatory response (GO:0002676) | 3.23082449 |
| 59 | positive regulation of ligase activity (GO:0051351) | 3.22555286 |
| 60 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.19700015 |
| 61 | cytochrome complex assembly (GO:0017004) | 3.14752904 |
| 62 | fucose catabolic process (GO:0019317) | 3.12505637 |
| 63 | L-fucose metabolic process (GO:0042354) | 3.12505637 |
| 64 | L-fucose catabolic process (GO:0042355) | 3.12505637 |
| 65 | GTP biosynthetic process (GO:0006183) | 3.07005850 |
| 66 | regulation of cellular amine metabolic process (GO:0033238) | 3.03301031 |
| 67 | tRNA processing (GO:0008033) | 3.00868232 |
| 68 | positive regulation of cell cycle arrest (GO:0071158) | 2.99572724 |
| 69 | ribosome assembly (GO:0042255) | 2.96401022 |
| 70 | signal peptide processing (GO:0006465) | 2.94455668 |
| 71 | regulation of immunoglobulin secretion (GO:0051023) | 2.92736646 |
| 72 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.92620793 |
| 73 | cellular response to interleukin-15 (GO:0071350) | 2.90499723 |
| 74 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.87392172 |
| 75 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.86528012 |
| 76 | tRNA metabolic process (GO:0006399) | 2.85328196 |
| 77 | negative regulation of telomere maintenance (GO:0032205) | 2.85274595 |
| 78 | mitochondrial RNA metabolic process (GO:0000959) | 2.84782505 |
| 79 | protein refolding (GO:0042026) | 2.84745610 |
| 80 | platelet dense granule organization (GO:0060155) | 2.83109939 |
| 81 | regulation of ligase activity (GO:0051340) | 2.82234168 |
| 82 | spliceosomal snRNP assembly (GO:0000387) | 2.81437893 |
| 83 | rRNA processing (GO:0006364) | 2.80602091 |
| 84 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 2.80027951 |
| 85 | rRNA metabolic process (GO:0016072) | 2.78237370 |
| 86 | protein targeting to mitochondrion (GO:0006626) | 2.73648625 |
| 87 | amino acid activation (GO:0043038) | 2.72786968 |
| 88 | tRNA aminoacylation (GO:0043039) | 2.72786968 |
| 89 | negative regulation of protein ubiquitination (GO:0031397) | 2.72336249 |
| 90 | maturation of SSU-rRNA (GO:0030490) | 2.70681847 |
| 91 | peptidyl-histidine modification (GO:0018202) | 2.69491096 |
| 92 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.69461245 |
| 93 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.68543223 |
| 94 | ubiquinone metabolic process (GO:0006743) | 2.67706502 |
| 95 | establishment of protein localization to mitochondrion (GO:0072655) | 2.64804138 |
| 96 | hydrogen ion transmembrane transport (GO:1902600) | 2.64740316 |
| 97 | tRNA aminoacylation for protein translation (GO:0006418) | 2.64656568 |
| 98 | protein localization to mitochondrion (GO:0070585) | 2.64058064 |
| 99 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.63043054 |
| 100 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.63043054 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.09192481 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.59252061 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.73021857 |
| 4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.45436587 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.40746906 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.20782060 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.94725711 |
| 8 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.93400234 |
| 9 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.93336636 |
| 10 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.73467014 |
| 11 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.61519055 |
| 12 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.54205603 |
| 13 | VDR_22108803_ChIP-Seq_LS180_Human | 2.52652906 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.48251390 |
| 15 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.40150066 |
| 16 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.39501445 |
| 17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.28542896 |
| 18 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.26724936 |
| 19 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.22817968 |
| 20 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.19290473 |
| 21 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.13689127 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.04131787 |
| 23 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.02454081 |
| 24 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.02423084 |
| 25 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.96471685 |
| 26 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.93020348 |
| 27 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.92947812 |
| 28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.85774873 |
| 29 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.84679936 |
| 30 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.81754952 |
| 31 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.75257777 |
| 32 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.71365856 |
| 33 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.69423402 |
| 34 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.62122630 |
| 35 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.58384033 |
| 36 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.57613940 |
| 37 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.52775477 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.51551432 |
| 39 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.50882922 |
| 40 | EWS_26573619_Chip-Seq_HEK293_Human | 1.50719997 |
| 41 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.50589831 |
| 42 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.47398888 |
| 43 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.47087705 |
| 44 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.46222406 |
| 45 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.44711146 |
| 46 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.41243506 |
| 47 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.35659676 |
| 48 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.28917996 |
| 49 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.27694738 |
| 50 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.26548565 |
| 51 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.22891998 |
| 52 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.22389482 |
| 53 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.21738174 |
| 54 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.21351735 |
| 55 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.19845647 |
| 56 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.18701722 |
| 57 | P300_19829295_ChIP-Seq_ESCs_Human | 1.18412440 |
| 58 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.17557640 |
| 59 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.16858127 |
| 60 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.16634644 |
| 61 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15158063 |
| 62 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.14836594 |
| 63 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.14836594 |
| 64 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.12673254 |
| 65 | FUS_26573619_Chip-Seq_HEK293_Human | 1.07284609 |
| 66 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.07171127 |
| 67 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.06503389 |
| 68 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.05372942 |
| 69 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.04750840 |
| 70 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.04734868 |
| 71 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.04568867 |
| 72 | GATA3_26560356_Chip-Seq_TH2_Human | 1.04232442 |
| 73 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.03799122 |
| 74 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.03180082 |
| 75 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.01424221 |
| 76 | NCOR_22424771_ChIP-Seq_293T_Human | 1.01361383 |
| 77 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.99613635 |
| 78 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.99208403 |
| 79 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.98499165 |
| 80 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.98017517 |
| 81 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.97690292 |
| 82 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.97690292 |
| 83 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.97550253 |
| 84 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.96757991 |
| 85 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.95825987 |
| 86 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.95584052 |
| 87 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.95153712 |
| 88 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.94880349 |
| 89 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.94517802 |
| 90 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.94345831 |
| 91 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.92981092 |
| 92 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.92038626 |
| 93 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.90937833 |
| 94 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.90576698 |
| 95 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.90121708 |
| 96 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.87749960 |
| 97 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.87597782 |
| 98 | AR_20517297_ChIP-Seq_VCAP_Human | 0.85396819 |
| 99 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85307815 |
| 100 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.84775286 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 3.74213112 |
| 2 | MP0002102_abnormal_ear_morphology | 2.94886875 |
| 3 | MP0001835_abnormal_antigen_presentation | 2.70580659 |
| 4 | MP0006072_abnormal_retinal_apoptosis | 2.54668784 |
| 5 | MP0009785_altered_susceptibility_to | 2.33110258 |
| 6 | MP0003693_abnormal_embryo_hatching | 2.26641162 |
| 7 | MP0008875_abnormal_xenobiotic_pharmacok | 2.25951425 |
| 8 | MP0003786_premature_aging | 2.19076855 |
| 9 | MP0008877_abnormal_DNA_methylation | 2.15136784 |
| 10 | MP0008058_abnormal_DNA_repair | 2.14957183 |
| 11 | MP0008872_abnormal_physiological_respon | 2.10424351 |
| 12 | MP0005645_abnormal_hypothalamus_physiol | 2.09770198 |
| 13 | MP0001873_stomach_inflammation | 2.02639079 |
| 14 | MP0003195_calcinosis | 1.92884651 |
| 15 | MP0004147_increased_porphyrin_level | 1.83469693 |
| 16 | MP0009333_abnormal_splenocyte_physiolog | 1.82175443 |
| 17 | MP0002837_dystrophic_cardiac_calcinosis | 1.78712120 |
| 18 | MP0002138_abnormal_hepatobiliary_system | 1.74110394 |
| 19 | MP0003718_maternal_effect | 1.72778054 |
| 20 | MP0003806_abnormal_nucleotide_metabolis | 1.70067718 |
| 21 | MP0005084_abnormal_gallbladder_morpholo | 1.68206754 |
| 22 | MP0006292_abnormal_olfactory_placode | 1.66978717 |
| 23 | MP0004142_abnormal_muscle_tone | 1.66751876 |
| 24 | MP0001529_abnormal_vocalization | 1.63698428 |
| 25 | MP0005387_immune_system_phenotype | 1.63313069 |
| 26 | MP0001790_abnormal_immune_system | 1.63313069 |
| 27 | MP0000685_abnormal_immune_system | 1.63052697 |
| 28 | MP0002148_abnormal_hypersensitivity_rea | 1.63004923 |
| 29 | MP0002166_altered_tumor_susceptibility | 1.61768463 |
| 30 | MP0008007_abnormal_cellular_replicative | 1.55933346 |
| 31 | MP0002277_abnormal_respiratory_mucosa | 1.55927329 |
| 32 | MP0003646_muscle_fatigue | 1.55160350 |
| 33 | MP0001905_abnormal_dopamine_level | 1.52528641 |
| 34 | MP0001188_hyperpigmentation | 1.52181668 |
| 35 | MP0005551_abnormal_eye_electrophysiolog | 1.51490862 |
| 36 | MP0006036_abnormal_mitochondrial_physio | 1.49239118 |
| 37 | MP0001800_abnormal_humoral_immune | 1.49216227 |
| 38 | MP0010094_abnormal_chromosome_stability | 1.47747254 |
| 39 | MP0006035_abnormal_mitochondrial_morpho | 1.43683188 |
| 40 | MP0001968_abnormal_touch/_nociception | 1.42600777 |
| 41 | MP0004957_abnormal_blastocyst_morpholog | 1.42351626 |
| 42 | MP0000372_irregular_coat_pigmentation | 1.40126529 |
| 43 | MP0002006_tumorigenesis | 1.39379045 |
| 44 | MP0002736_abnormal_nociception_after | 1.35216437 |
| 45 | MP0003186_abnormal_redox_activity | 1.33679410 |
| 46 | MP0004145_abnormal_muscle_electrophysio | 1.29536228 |
| 47 | MP0004885_abnormal_endolymph | 1.29009228 |
| 48 | MP0002876_abnormal_thyroid_physiology | 1.28812792 |
| 49 | MP0003763_abnormal_thymus_physiology | 1.26565369 |
| 50 | MP0002272_abnormal_nervous_system | 1.24886590 |
| 51 | MP0005253_abnormal_eye_physiology | 1.24429632 |
| 52 | MP0001919_abnormal_reproductive_system | 1.17833495 |
| 53 | MP0005000_abnormal_immune_tolerance | 1.15732455 |
| 54 | MP0005389_reproductive_system_phenotype | 1.15143898 |
| 55 | MP0003011_delayed_dark_adaptation | 1.14079003 |
| 56 | MP0009745_abnormal_behavioral_response | 1.13846244 |
| 57 | MP0006276_abnormal_autonomic_nervous | 1.11983339 |
| 58 | MP0002163_abnormal_gland_morphology | 1.11226886 |
| 59 | MP0002723_abnormal_immune_serum | 1.11095157 |
| 60 | MP0003866_abnormal_defecation | 1.05358791 |
| 61 | MP0002420_abnormal_adaptive_immunity | 1.03138569 |
| 62 | MP0004742_abnormal_vestibular_system | 1.01465979 |
| 63 | MP0001819_abnormal_immune_cell | 1.01356221 |
| 64 | MP0003567_abnormal_fetal_cardiomyocyte | 1.01104445 |
| 65 | MP0005636_abnormal_mineral_homeostasis | 1.01061408 |
| 66 | MP0001501_abnormal_sleep_pattern | 1.00762190 |
| 67 | MP0002751_abnormal_autonomic_nervous | 0.99746560 |
| 68 | MP0001984_abnormal_olfaction | 0.99706990 |
| 69 | MP0005379_endocrine/exocrine_gland_phen | 0.98030186 |
| 70 | MP0002452_abnormal_antigen_presenting | 0.97728979 |
| 71 | MP0001485_abnormal_pinna_reflex | 0.95920533 |
| 72 | MP0009379_abnormal_foot_pigmentation | 0.95908932 |
| 73 | MP0001986_abnormal_taste_sensitivity | 0.95341927 |
| 74 | MP0001348_abnormal_lacrimal_gland | 0.95151404 |
| 75 | MP0005410_abnormal_fertilization | 0.93213540 |
| 76 | MP0010155_abnormal_intestine_physiology | 0.92648445 |
| 77 | MP0003137_abnormal_impulse_conducting | 0.91480593 |
| 78 | MP0002160_abnormal_reproductive_system | 0.90614807 |
| 79 | MP0002638_abnormal_pupillary_reflex | 0.89712955 |
| 80 | MP0005025_abnormal_response_to | 0.88236856 |
| 81 | MP0008995_early_reproductive_senescence | 0.88102458 |
| 82 | MP0003111_abnormal_nucleus_morphology | 0.87554914 |
| 83 | MP0009764_decreased_sensitivity_to | 0.87396065 |
| 84 | MP0005085_abnormal_gallbladder_physiolo | 0.86200774 |
| 85 | MP0001845_abnormal_inflammatory_respons | 0.85553643 |
| 86 | MP0005332_abnormal_amino_acid | 0.81431956 |
| 87 | MP0005360_urolithiasis | 0.80784231 |
| 88 | MP0000689_abnormal_spleen_morphology | 0.80781834 |
| 89 | MP0006082_CNS_inflammation | 0.79722464 |
| 90 | MP0000716_abnormal_immune_system | 0.79092177 |
| 91 | MP0002405_respiratory_system_inflammati | 0.78209906 |
| 92 | MP0005075_abnormal_melanosome_morpholog | 0.78158630 |
| 93 | MP0003880_abnormal_central_pattern | 0.78133549 |
| 94 | MP0009046_muscle_twitch | 0.73886331 |
| 95 | MP0002398_abnormal_bone_marrow | 0.73868680 |
| 96 | MP0000703_abnormal_thymus_morphology | 0.73715044 |
| 97 | MP0003252_abnormal_bile_duct | 0.72833327 |
| 98 | MP0001853_heart_inflammation | 0.72325008 |
| 99 | MP0005646_abnormal_pituitary_gland | 0.72211601 |
| 100 | MP0002693_abnormal_pancreas_physiology | 0.71435358 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.92714472 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.29630615 |
| 3 | Mitochondrial inheritance (HP:0001427) | 4.23188619 |
| 4 | Acute encephalopathy (HP:0006846) | 4.22909232 |
| 5 | Increased CSF lactate (HP:0002490) | 4.11173068 |
| 6 | Progressive macrocephaly (HP:0004481) | 4.08923126 |
| 7 | Hepatocellular necrosis (HP:0001404) | 3.89125355 |
| 8 | Methylmalonic acidemia (HP:0002912) | 3.87515821 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 3.78990667 |
| 10 | Stomatitis (HP:0010280) | 3.57759959 |
| 11 | Hepatic necrosis (HP:0002605) | 3.55694000 |
| 12 | Lipid accumulation in hepatocytes (HP:0006561) | 3.52009460 |
| 13 | Methylmalonic aciduria (HP:0012120) | 3.45235850 |
| 14 | IgG deficiency (HP:0004315) | 3.36015545 |
| 15 | Increased serum lactate (HP:0002151) | 3.21981568 |
| 16 | Cerebral edema (HP:0002181) | 3.18570249 |
| 17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.97807549 |
| 18 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.97807549 |
| 19 | 3-Methylglutaconic aciduria (HP:0003535) | 2.91887436 |
| 20 | Renal Fanconi syndrome (HP:0001994) | 2.87777180 |
| 21 | Hypoproteinemia (HP:0003075) | 2.82347586 |
| 22 | Abnormality of the labia minora (HP:0012880) | 2.77453778 |
| 23 | Aplastic anemia (HP:0001915) | 2.75886645 |
| 24 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.75208285 |
| 25 | Lactic acidosis (HP:0003128) | 2.74668632 |
| 26 | Optic disc pallor (HP:0000543) | 2.74549232 |
| 27 | Renal cortical cysts (HP:0000803) | 2.67405255 |
| 28 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.64004691 |
| 29 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.58944232 |
| 30 | Increased intramyocellular lipid droplets (HP:0012240) | 2.57125731 |
| 31 | Abnormality of the pons (HP:0007361) | 2.51768244 |
| 32 | Leukodystrophy (HP:0002415) | 2.45867750 |
| 33 | Abnormality of the anterior horn cell (HP:0006802) | 2.45141004 |
| 34 | Degeneration of anterior horn cells (HP:0002398) | 2.45141004 |
| 35 | Abnormality of vitamin B metabolism (HP:0004340) | 2.42547455 |
| 36 | Exercise intolerance (HP:0003546) | 2.39427119 |
| 37 | Congenital, generalized hypertrichosis (HP:0004540) | 2.38015442 |
| 38 | Lethargy (HP:0001254) | 2.37913024 |
| 39 | Exertional dyspnea (HP:0002875) | 2.36516737 |
| 40 | Respiratory failure (HP:0002878) | 2.35250366 |
| 41 | Abnormality of T cell number (HP:0011839) | 2.34658991 |
| 42 | Hypothermia (HP:0002045) | 2.33856920 |
| 43 | Pancreatic cysts (HP:0001737) | 2.33729176 |
| 44 | Pendular nystagmus (HP:0012043) | 2.32304047 |
| 45 | Pancytopenia (HP:0001876) | 2.30626510 |
| 46 | Hypoplasia of the pons (HP:0012110) | 2.30506383 |
| 47 | Congenital stationary night blindness (HP:0007642) | 2.29812925 |
| 48 | T lymphocytopenia (HP:0005403) | 2.29606567 |
| 49 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.28753559 |
| 50 | Abolished electroretinogram (ERG) (HP:0000550) | 2.26696314 |
| 51 | Abnormality of T cells (HP:0002843) | 2.22149029 |
| 52 | Abnormality of methionine metabolism (HP:0010901) | 2.20905728 |
| 53 | Increased IgM level (HP:0003496) | 2.18422914 |
| 54 | Abnormality of the renal cortex (HP:0011035) | 2.16825129 |
| 55 | Hypomagnesemia (HP:0002917) | 2.16615825 |
| 56 | Progressive inability to walk (HP:0002505) | 2.15303402 |
| 57 | Abnormality of midbrain morphology (HP:0002418) | 2.14198002 |
| 58 | Molar tooth sign on MRI (HP:0002419) | 2.14198002 |
| 59 | Generalized aminoaciduria (HP:0002909) | 2.12046039 |
| 60 | Abnormality of the prostate (HP:0008775) | 2.10729349 |
| 61 | Meckel diverticulum (HP:0002245) | 2.10611979 |
| 62 | Oral leukoplakia (HP:0002745) | 2.07695932 |
| 63 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.06617316 |
| 64 | Increased muscle lipid content (HP:0009058) | 2.06345408 |
| 65 | Type I transferrin isoform profile (HP:0003642) | 2.05810545 |
| 66 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.00859754 |
| 67 | Dicarboxylic aciduria (HP:0003215) | 2.00859754 |
| 68 | Abnormality of homocysteine metabolism (HP:0010919) | 2.00291155 |
| 69 | Homocystinuria (HP:0002156) | 2.00291155 |
| 70 | Inability to walk (HP:0002540) | 1.99589912 |
| 71 | Hyperglycinemia (HP:0002154) | 1.97659523 |
| 72 | Abnormality of the ileum (HP:0001549) | 1.97479892 |
| 73 | Colon cancer (HP:0003003) | 1.96470471 |
| 74 | Severe combined immunodeficiency (HP:0004430) | 1.96401964 |
| 75 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.94419312 |
| 76 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.94419312 |
| 77 | Abnormal protein glycosylation (HP:0012346) | 1.94419312 |
| 78 | Abnormal glycosylation (HP:0012345) | 1.94419312 |
| 79 | Pancreatic fibrosis (HP:0100732) | 1.90562193 |
| 80 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.88494019 |
| 81 | Type II lissencephaly (HP:0007260) | 1.88483931 |
| 82 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.87826057 |
| 83 | CNS demyelination (HP:0007305) | 1.87461931 |
| 84 | Hyperalaninemia (HP:0003348) | 1.87177024 |
| 85 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.87177024 |
| 86 | Abnormality of alanine metabolism (HP:0010916) | 1.87177024 |
| 87 | Glycosuria (HP:0003076) | 1.86654942 |
| 88 | Abnormality of urine glucose concentration (HP:0011016) | 1.86654942 |
| 89 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.86140906 |
| 90 | Abnormality of T cell physiology (HP:0011840) | 1.86075433 |
| 91 | Chronic diarrhea (HP:0002028) | 1.85049272 |
| 92 | Abnormal albumin level (HP:0012116) | 1.84981552 |
| 93 | Hypoalbuminemia (HP:0003073) | 1.84981552 |
| 94 | Attenuation of retinal blood vessels (HP:0007843) | 1.83475634 |
| 95 | Abnormality of serum amino acid levels (HP:0003112) | 1.82703652 |
| 96 | Abnormality of magnesium homeostasis (HP:0004921) | 1.78123092 |
| 97 | True hermaphroditism (HP:0010459) | 1.76993066 |
| 98 | Microvesicular hepatic steatosis (HP:0001414) | 1.75433343 |
| 99 | Opisthotonus (HP:0002179) | 1.74866875 |
| 100 | Tongue fasciculations (HP:0001308) | 1.73042885 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TSSK6 | 5.69794413 |
| 2 | TXK | 3.23583261 |
| 3 | TLK1 | 2.75235413 |
| 4 | VRK2 | 2.70625973 |
| 5 | MAP4K2 | 2.68347753 |
| 6 | MST4 | 2.62242075 |
| 7 | BUB1 | 2.59956647 |
| 8 | ZAK | 2.58737707 |
| 9 | TRIM28 | 2.43305354 |
| 10 | NUAK1 | 2.42198094 |
| 11 | NEK1 | 2.13442250 |
| 12 | BCKDK | 2.08551175 |
| 13 | EIF2AK3 | 1.84354421 |
| 14 | VRK1 | 1.82847544 |
| 15 | SRPK1 | 1.82404835 |
| 16 | ADRBK2 | 1.75932318 |
| 17 | TAOK3 | 1.72669322 |
| 18 | PLK3 | 1.68787840 |
| 19 | BCR | 1.67397815 |
| 20 | TAF1 | 1.60810067 |
| 21 | WNK3 | 1.57210404 |
| 22 | GRK1 | 1.53926260 |
| 23 | MAP3K12 | 1.50748641 |
| 24 | STK16 | 1.47129728 |
| 25 | OXSR1 | 1.38363264 |
| 26 | EIF2AK1 | 1.35713070 |
| 27 | NME1 | 1.31225121 |
| 28 | CSNK1G3 | 1.29924718 |
| 29 | WNK4 | 1.26502939 |
| 30 | PBK | 1.24590042 |
| 31 | PINK1 | 1.23374137 |
| 32 | KDR | 1.23358981 |
| 33 | CSNK1G1 | 1.17021949 |
| 34 | TESK2 | 1.16891243 |
| 35 | CSNK1G2 | 1.15116429 |
| 36 | CSNK1A1L | 1.10688896 |
| 37 | FRK | 1.08570189 |
| 38 | STK39 | 1.08375757 |
| 39 | DYRK2 | 1.03294374 |
| 40 | CDC7 | 1.01132314 |
| 41 | RPS6KA4 | 1.00065305 |
| 42 | MKNK1 | 0.99151538 |
| 43 | ITK | 0.97666268 |
| 44 | MKNK2 | 0.94855531 |
| 45 | MINK1 | 0.93104543 |
| 46 | PASK | 0.84104218 |
| 47 | RPS6KA5 | 0.81838435 |
| 48 | BMPR1B | 0.80938992 |
| 49 | INSRR | 0.79887162 |
| 50 | ERBB3 | 0.79817537 |
| 51 | EIF2AK2 | 0.77899647 |
| 52 | ATR | 0.76313595 |
| 53 | MAP4K1 | 0.75180958 |
| 54 | PLK4 | 0.74174315 |
| 55 | MAPKAPK5 | 0.72526024 |
| 56 | TTK | 0.72448863 |
| 57 | TEC | 0.72175123 |
| 58 | PLK1 | 0.70645720 |
| 59 | ALK | 0.69003295 |
| 60 | PLK2 | 0.68243336 |
| 61 | DAPK1 | 0.68122118 |
| 62 | SIK3 | 0.68007682 |
| 63 | FES | 0.61155835 |
| 64 | IKBKB | 0.60247264 |
| 65 | IKBKE | 0.57906419 |
| 66 | MAP2K7 | 0.51874885 |
| 67 | TIE1 | 0.51815535 |
| 68 | CAMKK2 | 0.51765542 |
| 69 | PRKCQ | 0.49983043 |
| 70 | PAK3 | 0.47170262 |
| 71 | CDK19 | 0.47042287 |
| 72 | PRKCG | 0.44930511 |
| 73 | CSNK2A2 | 0.44218610 |
| 74 | AURKB | 0.42825118 |
| 75 | LIMK1 | 0.42812332 |
| 76 | SCYL2 | 0.41440713 |
| 77 | PRKCE | 0.41427900 |
| 78 | TESK1 | 0.41154602 |
| 79 | SYK | 0.40857945 |
| 80 | CSNK2A1 | 0.40673127 |
| 81 | CSNK1A1 | 0.40648564 |
| 82 | TNIK | 0.38093818 |
| 83 | AURKA | 0.37590367 |
| 84 | PDK2 | 0.36701768 |
| 85 | CAMK2A | 0.36406641 |
| 86 | LCK | 0.36210231 |
| 87 | PHKG1 | 0.35582219 |
| 88 | PHKG2 | 0.35582219 |
| 89 | MAP3K4 | 0.34090016 |
| 90 | MARK3 | 0.34012102 |
| 91 | ADRBK1 | 0.32815400 |
| 92 | MAP2K6 | 0.32093003 |
| 93 | ATM | 0.29595312 |
| 94 | CCNB1 | 0.28714866 |
| 95 | CASK | 0.27813043 |
| 96 | WEE1 | 0.27566632 |
| 97 | CSNK1E | 0.27115582 |
| 98 | PRKCA | 0.26991828 |
| 99 | PRKACA | 0.26943426 |
| 100 | GRK5 | 0.26606363 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.93672829 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.23906019 |
| 3 | Protein export_Homo sapiens_hsa03060 | 3.09052065 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 2.76141900 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 2.71325639 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.66636969 |
| 7 | Allograft rejection_Homo sapiens_hsa05330 | 2.39596791 |
| 8 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.31715561 |
| 9 | Asthma_Homo sapiens_hsa05310 | 2.18988673 |
| 10 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.04638892 |
| 11 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.92336608 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.85617576 |
| 13 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.76756312 |
| 14 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.74807016 |
| 15 | Ribosome_Homo sapiens_hsa03010 | 1.72331836 |
| 16 | Huntingtons disease_Homo sapiens_hsa05016 | 1.69681529 |
| 17 | Alzheimers disease_Homo sapiens_hsa05010 | 1.66466422 |
| 18 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.61416784 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.60049283 |
| 20 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.56662061 |
| 21 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.53549216 |
| 22 | Mismatch repair_Homo sapiens_hsa03430 | 1.49309443 |
| 23 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.49263682 |
| 24 | Basal transcription factors_Homo sapiens_hsa03022 | 1.48980055 |
| 25 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.42988214 |
| 26 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.42552113 |
| 27 | Spliceosome_Homo sapiens_hsa03040 | 1.41668543 |
| 28 | Phototransduction_Homo sapiens_hsa04744 | 1.39530123 |
| 29 | RNA transport_Homo sapiens_hsa03013 | 1.33201593 |
| 30 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.32816380 |
| 31 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.32451700 |
| 32 | Homologous recombination_Homo sapiens_hsa03440 | 1.30767839 |
| 33 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.30330658 |
| 34 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.30000360 |
| 35 | DNA replication_Homo sapiens_hsa03030 | 1.26594040 |
| 36 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.25627732 |
| 37 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.20155345 |
| 38 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.19325484 |
| 39 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.16811498 |
| 40 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.13871476 |
| 41 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.13822088 |
| 42 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.04911937 |
| 43 | Purine metabolism_Homo sapiens_hsa00230 | 1.04330484 |
| 44 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.02544284 |
| 45 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.01381467 |
| 46 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.00553404 |
| 47 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.98206472 |
| 48 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.96559820 |
| 49 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.96081692 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.95947592 |
| 51 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.94366826 |
| 52 | Peroxisome_Homo sapiens_hsa04146 | 0.94196643 |
| 53 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.93964449 |
| 54 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.84800737 |
| 55 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.83170218 |
| 56 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.82099874 |
| 57 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.80458164 |
| 58 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.79903636 |
| 59 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.78202422 |
| 60 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.70219610 |
| 61 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.69036838 |
| 62 | Viral myocarditis_Homo sapiens_hsa05416 | 0.66477555 |
| 63 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.66032213 |
| 64 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.65531137 |
| 65 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.64218315 |
| 66 | Base excision repair_Homo sapiens_hsa03410 | 0.64067992 |
| 67 | Metabolic pathways_Homo sapiens_hsa01100 | 0.61622689 |
| 68 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.60397507 |
| 69 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.57714205 |
| 70 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.57654603 |
| 71 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.57563151 |
| 72 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.57002513 |
| 73 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.56476163 |
| 74 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.55565574 |
| 75 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.54910069 |
| 76 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.54308220 |
| 77 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.52133757 |
| 78 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.49878389 |
| 79 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.49842263 |
| 80 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.48206447 |
| 81 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.47946913 |
| 82 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.45703142 |
| 83 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.43079039 |
| 84 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.42566763 |
| 85 | Nicotine addiction_Homo sapiens_hsa05033 | 0.39097328 |
| 86 | Sulfur relay system_Homo sapiens_hsa04122 | 0.38689218 |
| 87 | Measles_Homo sapiens_hsa05162 | 0.38632773 |
| 88 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.38236334 |
| 89 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.38014209 |
| 90 | Retinol metabolism_Homo sapiens_hsa00830 | 0.36537089 |
| 91 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.36329851 |
| 92 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.35809912 |
| 93 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.33609152 |
| 94 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.32609671 |
| 95 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.31872189 |
| 96 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.30420977 |
| 97 | Legionellosis_Homo sapiens_hsa05134 | 0.29284678 |
| 98 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.29170307 |
| 99 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.27730918 |
| 100 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.27514071 |

