HSPA8P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.15544651
2proteasome assembly (GO:0043248)4.61383223
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.60036354
4ATP synthesis coupled proton transport (GO:0015986)4.40389546
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.40389546
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.33432477
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.26712685
8regulation of cellular amino acid metabolic process (GO:0006521)4.22763928
9rRNA modification (GO:0000154)4.20502972
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.19335153
11water-soluble vitamin biosynthetic process (GO:0042364)4.09042664
12DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.02110839
13transcription elongation from RNA polymerase III promoter (GO:0006385)4.00643240
14termination of RNA polymerase III transcription (GO:0006386)4.00643240
15chaperone-mediated protein transport (GO:0072321)3.94657128
16positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.92881388
17signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.92631614
18signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.92631614
19signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.92631614
20cytidine deamination (GO:0009972)3.90903886
21cytidine metabolic process (GO:0046087)3.90903886
22cytidine catabolic process (GO:0006216)3.90903886
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.89857408
24signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.89857408
25negative regulation of ligase activity (GO:0051352)3.89174589
26negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.89174589
27protein neddylation (GO:0045116)3.87145876
28cullin deneddylation (GO:0010388)3.86267182
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.81161538
30rRNA methylation (GO:0031167)3.80658821
31protein complex biogenesis (GO:0070271)3.79858801
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.78947632
33signal transduction involved in DNA damage checkpoint (GO:0072422)3.76102252
34signal transduction involved in DNA integrity checkpoint (GO:0072401)3.76102252
35signal transduction involved in cell cycle checkpoint (GO:0072395)3.72923078
36mitochondrial respiratory chain complex assembly (GO:0033108)3.71308730
37protein deneddylation (GO:0000338)3.64438838
38protein-cofactor linkage (GO:0018065)3.61333967
39DNA damage response, detection of DNA damage (GO:0042769)3.57719960
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.56602681
41NADH dehydrogenase complex assembly (GO:0010257)3.56602681
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56602681
43DNA double-strand break processing (GO:0000729)3.56486096
44regulation of isotype switching to IgG isotypes (GO:0048302)3.53727966
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.53189013
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.52423934
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49677363
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.48672624
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.47513295
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.47513295
51pyrimidine ribonucleoside catabolic process (GO:0046133)3.42715164
52pseudouridine synthesis (GO:0001522)3.41922579
53respiratory chain complex IV assembly (GO:0008535)3.40233653
54positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.31017170
55respiratory electron transport chain (GO:0022904)3.29582968
56electron transport chain (GO:0022900)3.28194202
57maturation of 5.8S rRNA (GO:0000460)3.27608463
58regulation of chronic inflammatory response (GO:0002676)3.23082449
59positive regulation of ligase activity (GO:0051351)3.22555286
60antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.19700015
61cytochrome complex assembly (GO:0017004)3.14752904
62fucose catabolic process (GO:0019317)3.12505637
63L-fucose metabolic process (GO:0042354)3.12505637
64L-fucose catabolic process (GO:0042355)3.12505637
65GTP biosynthetic process (GO:0006183)3.07005850
66regulation of cellular amine metabolic process (GO:0033238)3.03301031
67tRNA processing (GO:0008033)3.00868232
68positive regulation of cell cycle arrest (GO:0071158)2.99572724
69ribosome assembly (GO:0042255)2.96401022
70signal peptide processing (GO:0006465)2.94455668
71regulation of immunoglobulin secretion (GO:0051023)2.92736646
72DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.92620793
73cellular response to interleukin-15 (GO:0071350)2.90499723
74regulation of ubiquitin-protein transferase activity (GO:0051438)2.87392172
75DNA catabolic process, exonucleolytic (GO:0000738)2.86528012
76tRNA metabolic process (GO:0006399)2.85328196
77negative regulation of telomere maintenance (GO:0032205)2.85274595
78mitochondrial RNA metabolic process (GO:0000959)2.84782505
79protein refolding (GO:0042026)2.84745610
80platelet dense granule organization (GO:0060155)2.83109939
81regulation of ligase activity (GO:0051340)2.82234168
82spliceosomal snRNP assembly (GO:0000387)2.81437893
83rRNA processing (GO:0006364)2.80602091
84positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.80027951
85rRNA metabolic process (GO:0016072)2.78237370
86protein targeting to mitochondrion (GO:0006626)2.73648625
87amino acid activation (GO:0043038)2.72786968
88tRNA aminoacylation (GO:0043039)2.72786968
89negative regulation of protein ubiquitination (GO:0031397)2.72336249
90maturation of SSU-rRNA (GO:0030490)2.70681847
91peptidyl-histidine modification (GO:0018202)2.69491096
92antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.69461245
93chaperone mediated protein folding requiring cofactor (GO:0051085)2.68543223
94ubiquinone metabolic process (GO:0006743)2.67706502
95establishment of protein localization to mitochondrion (GO:0072655)2.64804138
96hydrogen ion transmembrane transport (GO:1902600)2.64740316
97tRNA aminoacylation for protein translation (GO:0006418)2.64656568
98protein localization to mitochondrion (GO:0070585)2.64058064
99regulation of mitotic spindle checkpoint (GO:1903504)2.63043054
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.63043054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.09192481
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.59252061
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.73021857
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.45436587
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.40746906
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20782060
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.94725711
8VDR_23849224_ChIP-Seq_CD4+_Human2.93400234
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.93336636
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73467014
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61519055
12ELK1_19687146_ChIP-ChIP_HELA_Human2.54205603
13VDR_22108803_ChIP-Seq_LS180_Human2.52652906
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48251390
15ZNF274_21170338_ChIP-Seq_K562_Hela2.40150066
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39501445
17FOXP3_21729870_ChIP-Seq_TREG_Human2.28542896
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.26724936
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.22817968
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19290473
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13689127
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.04131787
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.02454081
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02423084
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96471685
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93020348
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.92947812
28DCP1A_22483619_ChIP-Seq_HELA_Human1.85774873
29MYC_18940864_ChIP-ChIP_HL60_Human1.84679936
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81754952
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.75257777
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71365856
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69423402
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62122630
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58384033
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57613940
37GABP_19822575_ChIP-Seq_HepG2_Human1.52775477
38TTF2_22483619_ChIP-Seq_HELA_Human1.51551432
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50882922
40EWS_26573619_Chip-Seq_HEK293_Human1.50719997
41TP53_22573176_ChIP-Seq_HFKS_Human1.50589831
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47398888
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47087705
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46222406
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44711146
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41243506
47IGF1R_20145208_ChIP-Seq_DFB_Human1.35659676
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28917996
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27694738
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26548565
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22891998
52IRF1_19129219_ChIP-ChIP_H3396_Human1.22389482
53XRN2_22483619_ChIP-Seq_HELA_Human1.21738174
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21351735
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.19845647
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18701722
57P300_19829295_ChIP-Seq_ESCs_Human1.18412440
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.17557640
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16858127
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16634644
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15158063
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.14836594
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14836594
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12673254
65FUS_26573619_Chip-Seq_HEK293_Human1.07284609
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07171127
67TAF15_26573619_Chip-Seq_HEK293_Human1.06503389
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05372942
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04750840
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04734868
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04568867
72GATA3_26560356_Chip-Seq_TH2_Human1.04232442
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03799122
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03180082
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01424221
76NCOR_22424771_ChIP-Seq_293T_Human1.01361383
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99613635
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99208403
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98499165
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98017517
81SOX2_19829295_ChIP-Seq_ESCs_Human0.97690292
82NANOG_19829295_ChIP-Seq_ESCs_Human0.97690292
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97550253
84IRF8_21731497_ChIP-ChIP_J774_Mouse0.96757991
85POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95825987
86IRF8_22096565_ChIP-ChIP_GC-B_Human0.95584052
87POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95153712
88NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94880349
89ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94517802
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.94345831
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92981092
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92038626
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90937833
94CIITA_25753668_ChIP-Seq_RAJI_Human0.90576698
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90121708
96CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87749960
97ER_23166858_ChIP-Seq_MCF-7_Human0.87597782
98AR_20517297_ChIP-Seq_VCAP_Human0.85396819
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85307815
100HTT_18923047_ChIP-ChIP_STHdh_Human0.84775286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.74213112
2MP0002102_abnormal_ear_morphology2.94886875
3MP0001835_abnormal_antigen_presentation2.70580659
4MP0006072_abnormal_retinal_apoptosis2.54668784
5MP0009785_altered_susceptibility_to2.33110258
6MP0003693_abnormal_embryo_hatching2.26641162
7MP0008875_abnormal_xenobiotic_pharmacok2.25951425
8MP0003786_premature_aging2.19076855
9MP0008877_abnormal_DNA_methylation2.15136784
10MP0008058_abnormal_DNA_repair2.14957183
11MP0008872_abnormal_physiological_respon2.10424351
12MP0005645_abnormal_hypothalamus_physiol2.09770198
13MP0001873_stomach_inflammation2.02639079
14MP0003195_calcinosis1.92884651
15MP0004147_increased_porphyrin_level1.83469693
16MP0009333_abnormal_splenocyte_physiolog1.82175443
17MP0002837_dystrophic_cardiac_calcinosis1.78712120
18MP0002138_abnormal_hepatobiliary_system1.74110394
19MP0003718_maternal_effect1.72778054
20MP0003806_abnormal_nucleotide_metabolis1.70067718
21MP0005084_abnormal_gallbladder_morpholo1.68206754
22MP0006292_abnormal_olfactory_placode1.66978717
23MP0004142_abnormal_muscle_tone1.66751876
24MP0001529_abnormal_vocalization1.63698428
25MP0005387_immune_system_phenotype1.63313069
26MP0001790_abnormal_immune_system1.63313069
27MP0000685_abnormal_immune_system1.63052697
28MP0002148_abnormal_hypersensitivity_rea1.63004923
29MP0002166_altered_tumor_susceptibility1.61768463
30MP0008007_abnormal_cellular_replicative1.55933346
31MP0002277_abnormal_respiratory_mucosa1.55927329
32MP0003646_muscle_fatigue1.55160350
33MP0001905_abnormal_dopamine_level1.52528641
34MP0001188_hyperpigmentation1.52181668
35MP0005551_abnormal_eye_electrophysiolog1.51490862
36MP0006036_abnormal_mitochondrial_physio1.49239118
37MP0001800_abnormal_humoral_immune1.49216227
38MP0010094_abnormal_chromosome_stability1.47747254
39MP0006035_abnormal_mitochondrial_morpho1.43683188
40MP0001968_abnormal_touch/_nociception1.42600777
41MP0004957_abnormal_blastocyst_morpholog1.42351626
42MP0000372_irregular_coat_pigmentation1.40126529
43MP0002006_tumorigenesis1.39379045
44MP0002736_abnormal_nociception_after1.35216437
45MP0003186_abnormal_redox_activity1.33679410
46MP0004145_abnormal_muscle_electrophysio1.29536228
47MP0004885_abnormal_endolymph1.29009228
48MP0002876_abnormal_thyroid_physiology1.28812792
49MP0003763_abnormal_thymus_physiology1.26565369
50MP0002272_abnormal_nervous_system1.24886590
51MP0005253_abnormal_eye_physiology1.24429632
52MP0001919_abnormal_reproductive_system1.17833495
53MP0005000_abnormal_immune_tolerance1.15732455
54MP0005389_reproductive_system_phenotype1.15143898
55MP0003011_delayed_dark_adaptation1.14079003
56MP0009745_abnormal_behavioral_response1.13846244
57MP0006276_abnormal_autonomic_nervous1.11983339
58MP0002163_abnormal_gland_morphology1.11226886
59MP0002723_abnormal_immune_serum1.11095157
60MP0003866_abnormal_defecation1.05358791
61MP0002420_abnormal_adaptive_immunity1.03138569
62MP0004742_abnormal_vestibular_system1.01465979
63MP0001819_abnormal_immune_cell1.01356221
64MP0003567_abnormal_fetal_cardiomyocyte1.01104445
65MP0005636_abnormal_mineral_homeostasis1.01061408
66MP0001501_abnormal_sleep_pattern1.00762190
67MP0002751_abnormal_autonomic_nervous0.99746560
68MP0001984_abnormal_olfaction0.99706990
69MP0005379_endocrine/exocrine_gland_phen0.98030186
70MP0002452_abnormal_antigen_presenting0.97728979
71MP0001485_abnormal_pinna_reflex0.95920533
72MP0009379_abnormal_foot_pigmentation0.95908932
73MP0001986_abnormal_taste_sensitivity0.95341927
74MP0001348_abnormal_lacrimal_gland0.95151404
75MP0005410_abnormal_fertilization0.93213540
76MP0010155_abnormal_intestine_physiology0.92648445
77MP0003137_abnormal_impulse_conducting0.91480593
78MP0002160_abnormal_reproductive_system0.90614807
79MP0002638_abnormal_pupillary_reflex0.89712955
80MP0005025_abnormal_response_to0.88236856
81MP0008995_early_reproductive_senescence0.88102458
82MP0003111_abnormal_nucleus_morphology0.87554914
83MP0009764_decreased_sensitivity_to0.87396065
84MP0005085_abnormal_gallbladder_physiolo0.86200774
85MP0001845_abnormal_inflammatory_respons0.85553643
86MP0005332_abnormal_amino_acid0.81431956
87MP0005360_urolithiasis0.80784231
88MP0000689_abnormal_spleen_morphology0.80781834
89MP0006082_CNS_inflammation0.79722464
90MP0000716_abnormal_immune_system0.79092177
91MP0002405_respiratory_system_inflammati0.78209906
92MP0005075_abnormal_melanosome_morpholog0.78158630
93MP0003880_abnormal_central_pattern0.78133549
94MP0009046_muscle_twitch0.73886331
95MP0002398_abnormal_bone_marrow0.73868680
96MP0000703_abnormal_thymus_morphology0.73715044
97MP0003252_abnormal_bile_duct0.72833327
98MP0001853_heart_inflammation0.72325008
99MP0005646_abnormal_pituitary_gland0.72211601
100MP0002693_abnormal_pancreas_physiology0.71435358

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.92714472
2Abnormal mitochondria in muscle tissue (HP:0008316)4.29630615
3Mitochondrial inheritance (HP:0001427)4.23188619
4Acute encephalopathy (HP:0006846)4.22909232
5Increased CSF lactate (HP:0002490)4.11173068
6Progressive macrocephaly (HP:0004481)4.08923126
7Hepatocellular necrosis (HP:0001404)3.89125355
8Methylmalonic acidemia (HP:0002912)3.87515821
9Increased hepatocellular lipid droplets (HP:0006565)3.78990667
10Stomatitis (HP:0010280)3.57759959
11Hepatic necrosis (HP:0002605)3.55694000
12Lipid accumulation in hepatocytes (HP:0006561)3.52009460
13Methylmalonic aciduria (HP:0012120)3.45235850
14IgG deficiency (HP:0004315)3.36015545
15Increased serum lactate (HP:0002151)3.21981568
16Cerebral edema (HP:0002181)3.18570249
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97807549
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97807549
193-Methylglutaconic aciduria (HP:0003535)2.91887436
20Renal Fanconi syndrome (HP:0001994)2.87777180
21Hypoproteinemia (HP:0003075)2.82347586
22Abnormality of the labia minora (HP:0012880)2.77453778
23Aplastic anemia (HP:0001915)2.75886645
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75208285
25Lactic acidosis (HP:0003128)2.74668632
26Optic disc pallor (HP:0000543)2.74549232
27Renal cortical cysts (HP:0000803)2.67405255
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.64004691
29Abnormality of the vitamin B12 metabolism (HP:0004341)2.58944232
30Increased intramyocellular lipid droplets (HP:0012240)2.57125731
31Abnormality of the pons (HP:0007361)2.51768244
32Leukodystrophy (HP:0002415)2.45867750
33Abnormality of the anterior horn cell (HP:0006802)2.45141004
34Degeneration of anterior horn cells (HP:0002398)2.45141004
35Abnormality of vitamin B metabolism (HP:0004340)2.42547455
36Exercise intolerance (HP:0003546)2.39427119
37Congenital, generalized hypertrichosis (HP:0004540)2.38015442
38Lethargy (HP:0001254)2.37913024
39Exertional dyspnea (HP:0002875)2.36516737
40Respiratory failure (HP:0002878)2.35250366
41Abnormality of T cell number (HP:0011839)2.34658991
42Hypothermia (HP:0002045)2.33856920
43Pancreatic cysts (HP:0001737)2.33729176
44Pendular nystagmus (HP:0012043)2.32304047
45Pancytopenia (HP:0001876)2.30626510
46Hypoplasia of the pons (HP:0012110)2.30506383
47Congenital stationary night blindness (HP:0007642)2.29812925
48T lymphocytopenia (HP:0005403)2.29606567
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28753559
50Abolished electroretinogram (ERG) (HP:0000550)2.26696314
51Abnormality of T cells (HP:0002843)2.22149029
52Abnormality of methionine metabolism (HP:0010901)2.20905728
53Increased IgM level (HP:0003496)2.18422914
54Abnormality of the renal cortex (HP:0011035)2.16825129
55Hypomagnesemia (HP:0002917)2.16615825
56Progressive inability to walk (HP:0002505)2.15303402
57Abnormality of midbrain morphology (HP:0002418)2.14198002
58Molar tooth sign on MRI (HP:0002419)2.14198002
59Generalized aminoaciduria (HP:0002909)2.12046039
60Abnormality of the prostate (HP:0008775)2.10729349
61Meckel diverticulum (HP:0002245)2.10611979
62Oral leukoplakia (HP:0002745)2.07695932
63Elevated erythrocyte sedimentation rate (HP:0003565)2.06617316
64Increased muscle lipid content (HP:0009058)2.06345408
65Type I transferrin isoform profile (HP:0003642)2.05810545
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00859754
67Dicarboxylic aciduria (HP:0003215)2.00859754
68Abnormality of homocysteine metabolism (HP:0010919)2.00291155
69Homocystinuria (HP:0002156)2.00291155
70Inability to walk (HP:0002540)1.99589912
71Hyperglycinemia (HP:0002154)1.97659523
72Abnormality of the ileum (HP:0001549)1.97479892
73Colon cancer (HP:0003003)1.96470471
74Severe combined immunodeficiency (HP:0004430)1.96401964
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94419312
76Abnormal protein N-linked glycosylation (HP:0012347)1.94419312
77Abnormal protein glycosylation (HP:0012346)1.94419312
78Abnormal glycosylation (HP:0012345)1.94419312
79Pancreatic fibrosis (HP:0100732)1.90562193
80Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88494019
81Type II lissencephaly (HP:0007260)1.88483931
82Aplasia/hypoplasia of the uterus (HP:0008684)1.87826057
83CNS demyelination (HP:0007305)1.87461931
84Hyperalaninemia (HP:0003348)1.87177024
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87177024
86Abnormality of alanine metabolism (HP:0010916)1.87177024
87Glycosuria (HP:0003076)1.86654942
88Abnormality of urine glucose concentration (HP:0011016)1.86654942
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.86140906
90Abnormality of T cell physiology (HP:0011840)1.86075433
91Chronic diarrhea (HP:0002028)1.85049272
92Abnormal albumin level (HP:0012116)1.84981552
93Hypoalbuminemia (HP:0003073)1.84981552
94Attenuation of retinal blood vessels (HP:0007843)1.83475634
95Abnormality of serum amino acid levels (HP:0003112)1.82703652
96Abnormality of magnesium homeostasis (HP:0004921)1.78123092
97True hermaphroditism (HP:0010459)1.76993066
98Microvesicular hepatic steatosis (HP:0001414)1.75433343
99Opisthotonus (HP:0002179)1.74866875
100Tongue fasciculations (HP:0001308)1.73042885

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.69794413
2TXK3.23583261
3TLK12.75235413
4VRK22.70625973
5MAP4K22.68347753
6MST42.62242075
7BUB12.59956647
8ZAK2.58737707
9TRIM282.43305354
10NUAK12.42198094
11NEK12.13442250
12BCKDK2.08551175
13EIF2AK31.84354421
14VRK11.82847544
15SRPK11.82404835
16ADRBK21.75932318
17TAOK31.72669322
18PLK31.68787840
19BCR1.67397815
20TAF11.60810067
21WNK31.57210404
22GRK11.53926260
23MAP3K121.50748641
24STK161.47129728
25OXSR11.38363264
26EIF2AK11.35713070
27NME11.31225121
28CSNK1G31.29924718
29WNK41.26502939
30PBK1.24590042
31PINK11.23374137
32KDR1.23358981
33CSNK1G11.17021949
34TESK21.16891243
35CSNK1G21.15116429
36CSNK1A1L1.10688896
37FRK1.08570189
38STK391.08375757
39DYRK21.03294374
40CDC71.01132314
41RPS6KA41.00065305
42MKNK10.99151538
43ITK0.97666268
44MKNK20.94855531
45MINK10.93104543
46PASK0.84104218
47RPS6KA50.81838435
48BMPR1B0.80938992
49INSRR0.79887162
50ERBB30.79817537
51EIF2AK20.77899647
52ATR0.76313595
53MAP4K10.75180958
54PLK40.74174315
55MAPKAPK50.72526024
56TTK0.72448863
57TEC0.72175123
58PLK10.70645720
59ALK0.69003295
60PLK20.68243336
61DAPK10.68122118
62SIK30.68007682
63FES0.61155835
64IKBKB0.60247264
65IKBKE0.57906419
66MAP2K70.51874885
67TIE10.51815535
68CAMKK20.51765542
69PRKCQ0.49983043
70PAK30.47170262
71CDK190.47042287
72PRKCG0.44930511
73CSNK2A20.44218610
74AURKB0.42825118
75LIMK10.42812332
76SCYL20.41440713
77PRKCE0.41427900
78TESK10.41154602
79SYK0.40857945
80CSNK2A10.40673127
81CSNK1A10.40648564
82TNIK0.38093818
83AURKA0.37590367
84PDK20.36701768
85CAMK2A0.36406641
86LCK0.36210231
87PHKG10.35582219
88PHKG20.35582219
89MAP3K40.34090016
90MARK30.34012102
91ADRBK10.32815400
92MAP2K60.32093003
93ATM0.29595312
94CCNB10.28714866
95CASK0.27813043
96WEE10.27566632
97CSNK1E0.27115582
98PRKCA0.26991828
99PRKACA0.26943426
100GRK50.26606363

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.93672829
2Oxidative phosphorylation_Homo sapiens_hsa001903.23906019
3Protein export_Homo sapiens_hsa030603.09052065
4RNA polymerase_Homo sapiens_hsa030202.76141900
5Parkinsons disease_Homo sapiens_hsa050122.71325639
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66636969
7Allograft rejection_Homo sapiens_hsa053302.39596791
8Autoimmune thyroid disease_Homo sapiens_hsa053202.31715561
9Asthma_Homo sapiens_hsa053102.18988673
10Type I diabetes mellitus_Homo sapiens_hsa049402.04638892
11Primary immunodeficiency_Homo sapiens_hsa053401.92336608
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85617576
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.76756312
14Graft-versus-host disease_Homo sapiens_hsa053321.74807016
15Ribosome_Homo sapiens_hsa030101.72331836
16Huntingtons disease_Homo sapiens_hsa050161.69681529
17Alzheimers disease_Homo sapiens_hsa050101.66466422
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61416784
19RNA degradation_Homo sapiens_hsa030181.60049283
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56662061
21Antigen processing and presentation_Homo sapiens_hsa046121.53549216
22Mismatch repair_Homo sapiens_hsa034301.49309443
23One carbon pool by folate_Homo sapiens_hsa006701.49263682
24Basal transcription factors_Homo sapiens_hsa030221.48980055
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42988214
26Sulfur metabolism_Homo sapiens_hsa009201.42552113
27Spliceosome_Homo sapiens_hsa030401.41668543
28Phototransduction_Homo sapiens_hsa047441.39530123
29RNA transport_Homo sapiens_hsa030131.33201593
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32816380
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32451700
32Homologous recombination_Homo sapiens_hsa034401.30767839
33Propanoate metabolism_Homo sapiens_hsa006401.30330658
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30000360
35DNA replication_Homo sapiens_hsa030301.26594040
36Pyrimidine metabolism_Homo sapiens_hsa002401.25627732
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20155345
38Caffeine metabolism_Homo sapiens_hsa002321.19325484
39Rheumatoid arthritis_Homo sapiens_hsa053231.16811498
40Collecting duct acid secretion_Homo sapiens_hsa049661.13871476
41Fanconi anemia pathway_Homo sapiens_hsa034601.13822088
42Non-homologous end-joining_Homo sapiens_hsa034501.04911937
43Purine metabolism_Homo sapiens_hsa002301.04330484
44Cardiac muscle contraction_Homo sapiens_hsa042601.02544284
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01381467
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00553404
47Linoleic acid metabolism_Homo sapiens_hsa005910.98206472
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96559820
49Nucleotide excision repair_Homo sapiens_hsa034200.96081692
50Steroid biosynthesis_Homo sapiens_hsa001000.95947592
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94366826
52Peroxisome_Homo sapiens_hsa041460.94196643
53Nitrogen metabolism_Homo sapiens_hsa009100.93964449
54Selenocompound metabolism_Homo sapiens_hsa004500.84800737
55Hematopoietic cell lineage_Homo sapiens_hsa046400.83170218
56Butanoate metabolism_Homo sapiens_hsa006500.82099874
57Tryptophan metabolism_Homo sapiens_hsa003800.80458164
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.79903636
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.78202422
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70219610
61Systemic lupus erythematosus_Homo sapiens_hsa053220.69036838
62Viral myocarditis_Homo sapiens_hsa054160.66477555
63Pyruvate metabolism_Homo sapiens_hsa006200.66032213
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65531137
65Ether lipid metabolism_Homo sapiens_hsa005650.64218315
66Base excision repair_Homo sapiens_hsa034100.64067992
67Metabolic pathways_Homo sapiens_hsa011000.61622689
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60397507
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57714205
70Fatty acid elongation_Homo sapiens_hsa000620.57654603
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57563151
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57002513
73Epstein-Barr virus infection_Homo sapiens_hsa051690.56476163
74Fat digestion and absorption_Homo sapiens_hsa049750.55565574
75Regulation of autophagy_Homo sapiens_hsa041400.54910069
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54308220
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52133757
78beta-Alanine metabolism_Homo sapiens_hsa004100.49878389
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49842263
80Vitamin B6 metabolism_Homo sapiens_hsa007500.48206447
81Folate biosynthesis_Homo sapiens_hsa007900.47946913
82T cell receptor signaling pathway_Homo sapiens_hsa046600.45703142
83Vitamin digestion and absorption_Homo sapiens_hsa049770.43079039
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42566763
85Nicotine addiction_Homo sapiens_hsa050330.39097328
86Sulfur relay system_Homo sapiens_hsa041220.38689218
87Measles_Homo sapiens_hsa051620.38632773
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38236334
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38014209
90Retinol metabolism_Homo sapiens_hsa008300.36537089
91Chemical carcinogenesis_Homo sapiens_hsa052040.36329851
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35809912
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.33609152
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.32609671
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31872189
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30420977
97Legionellosis_Homo sapiens_hsa051340.29284678
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29170307
99Glutathione metabolism_Homo sapiens_hsa004800.27730918
100mRNA surveillance pathway_Homo sapiens_hsa030150.27514071

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