HSPA8P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.45962358
2proteasome assembly (GO:0043248)5.00504430
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.77444658
4protein neddylation (GO:0045116)4.75213944
5DNA double-strand break processing (GO:0000729)4.19810215
6cullin deneddylation (GO:0010388)4.17420398
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.16465824
8rRNA modification (GO:0000154)4.07782931
9regulation of cellular amino acid metabolic process (GO:0006521)4.01548396
10nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.94537962
11exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.94198726
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.86992136
13positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.80761646
14pseudouridine synthesis (GO:0001522)3.80643514
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80284139
16ATP synthesis coupled proton transport (GO:0015986)3.80284139
17protein deneddylation (GO:0000338)3.78349666
18DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.75984646
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.74584119
20negative regulation of ligase activity (GO:0051352)3.72268075
21negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.72268075
22signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.69475805
23signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.69475805
24signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.69475805
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.65662864
26intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.65662864
27rRNA methylation (GO:0031167)3.64984703
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.62232718
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.62232718
30termination of RNA polymerase III transcription (GO:0006386)3.59277519
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.59277519
32water-soluble vitamin biosynthetic process (GO:0042364)3.58027115
33signal transduction involved in DNA integrity checkpoint (GO:0072401)3.51929807
34signal transduction involved in DNA damage checkpoint (GO:0072422)3.51929807
35maturation of 5.8S rRNA (GO:0000460)3.51726844
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.48664427
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.42785581
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.40599239
39DNA damage response, detection of DNA damage (GO:0042769)3.40306791
40platelet dense granule organization (GO:0060155)3.39739027
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38831157
42somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.35287675
43somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.35287675
44isotype switching (GO:0045190)3.35287675
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.34050346
46respiratory chain complex IV assembly (GO:0008535)3.33363888
47DNA catabolic process, exonucleolytic (GO:0000738)3.30634017
48chaperone-mediated protein transport (GO:0072321)3.24806434
49positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.22957526
50ribosome assembly (GO:0042255)3.21285839
51protein complex biogenesis (GO:0070271)3.21165423
52cytidine metabolic process (GO:0046087)3.20216535
53cytidine catabolic process (GO:0006216)3.20216535
54cytidine deamination (GO:0009972)3.20216535
55mitochondrial respiratory chain complex assembly (GO:0033108)3.18927504
56tRNA processing (GO:0008033)3.16884577
57regulation of mitotic spindle checkpoint (GO:1903504)3.15207491
58regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15207491
59mannosylation (GO:0097502)3.14188349
60positive regulation of ligase activity (GO:0051351)3.13084228
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.05753045
62peptidyl-histidine modification (GO:0018202)3.00000677
63protein-cofactor linkage (GO:0018065)2.99535872
64mitochondrial RNA metabolic process (GO:0000959)2.98185709
65tRNA metabolic process (GO:0006399)2.96800030
66purine nucleobase biosynthetic process (GO:0009113)2.95599255
67mitochondrial respiratory chain complex I assembly (GO:0032981)2.94424521
68NADH dehydrogenase complex assembly (GO:0010257)2.94424521
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94424521
70histone mRNA metabolic process (GO:0008334)2.94048507
71IMP biosynthetic process (GO:0006188)2.91211912
72cytochrome complex assembly (GO:0017004)2.91206210
73negative regulation of DNA-dependent DNA replication (GO:2000104)2.89504812
74regulation of cellular amine metabolic process (GO:0033238)2.87898695
75spliceosomal snRNP assembly (GO:0000387)2.87429344
76inner mitochondrial membrane organization (GO:0007007)2.87124338
77protein refolding (GO:0042026)2.85240811
78respiratory electron transport chain (GO:0022904)2.83660697
79positive regulation of cell cycle arrest (GO:0071158)2.83412512
80electron transport chain (GO:0022900)2.82455868
81antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80275903
82nucleobase biosynthetic process (GO:0046112)2.79532594
83regulation of ubiquitin-protein transferase activity (GO:0051438)2.77245806
84DNA replication checkpoint (GO:0000076)2.75623570
85DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.74949267
86tRNA modification (GO:0006400)2.73850873
87intracellular protein transmembrane import (GO:0044743)2.73208155
88branched-chain amino acid catabolic process (GO:0009083)2.73017783
89preassembly of GPI anchor in ER membrane (GO:0016254)2.72040164
90regulation of ligase activity (GO:0051340)2.70984951
91chromatin remodeling at centromere (GO:0031055)2.70676116
92negative regulation of protein ubiquitination (GO:0031397)2.70515935
93negative regulation of telomere maintenance (GO:0032205)2.70190113
94L-fucose catabolic process (GO:0042355)2.69458735
95fucose catabolic process (GO:0019317)2.69458735
96L-fucose metabolic process (GO:0042354)2.69458735
97pyrimidine ribonucleoside catabolic process (GO:0046133)2.68355792
98protein localization to mitochondrion (GO:0070585)2.67738269
99CENP-A containing nucleosome assembly (GO:0034080)2.66956381
100protein targeting to mitochondrion (GO:0006626)2.65502550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.00804119
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.46733552
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.75540085
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.31458318
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.09581809
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96195929
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95430589
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91776984
9VDR_23849224_ChIP-Seq_CD4+_Human2.89146850
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.82134678
11VDR_22108803_ChIP-Seq_LS180_Human2.80618449
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77615729
13ELK1_19687146_ChIP-ChIP_HELA_Human2.58913764
14ZNF274_21170338_ChIP-Seq_K562_Hela2.58420722
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.45034343
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42736575
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42548899
18FOXP3_21729870_ChIP-Seq_TREG_Human2.39241322
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.27732317
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18835464
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.16750431
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.13782151
23E2F7_22180533_ChIP-Seq_HELA_Human2.02174249
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96576274
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.93545377
26IGF1R_20145208_ChIP-Seq_DFB_Human1.89122701
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87023840
28EWS_26573619_Chip-Seq_HEK293_Human1.86099454
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85433359
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83738597
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73844254
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67636784
33MYC_18940864_ChIP-ChIP_HL60_Human1.65573763
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57565739
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56673520
36DCP1A_22483619_ChIP-Seq_HELA_Human1.56295600
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51410794
38GABP_19822575_ChIP-Seq_HepG2_Human1.51153824
39FUS_26573619_Chip-Seq_HEK293_Human1.50465783
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49749993
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49652353
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48197981
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42069966
44TTF2_22483619_ChIP-Seq_HELA_Human1.41156881
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40890645
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35635802
47TP53_22573176_ChIP-Seq_HFKS_Human1.33994673
48P300_19829295_ChIP-Seq_ESCs_Human1.29393531
49TAF15_26573619_Chip-Seq_HEK293_Human1.28946671
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28555488
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22997884
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22273965
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.21042986
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19666436
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.19406039
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18808521
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17898795
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14947248
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13487048
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.13487048
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13464439
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12781137
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11110940
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09008985
65GATA3_26560356_Chip-Seq_TH2_Human1.09008962
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.06716383
67NANOG_19829295_ChIP-Seq_ESCs_Human1.05657727
68SOX2_19829295_ChIP-Seq_ESCs_Human1.05657727
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04843518
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04720708
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03978960
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03171794
73AR_20517297_ChIP-Seq_VCAP_Human1.02776921
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.02665464
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02267419
76ER_23166858_ChIP-Seq_MCF-7_Human1.02069501
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00552871
78FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98946433
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98717343
80POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96825771
81CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95671675
82SALL1_21062744_ChIP-ChIP_HESCs_Human0.95302977
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93995167
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93669869
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93396825
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92855558
87IRF1_19129219_ChIP-ChIP_H3396_Human0.92760998
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91903326
89CBP_20019798_ChIP-Seq_JUKART_Human0.91704759
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91704759
91XRN2_22483619_ChIP-Seq_HELA_Human0.91531505
92CIITA_25753668_ChIP-Seq_RAJI_Human0.90761689
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90073646
94CRX_20693478_ChIP-Seq_RETINA_Mouse0.89911346
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86866398
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.86684488
97NCOR_22424771_ChIP-Seq_293T_Human0.86547237
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85627787
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85335255
100EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85226506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.07119208
2MP0002102_abnormal_ear_morphology3.01275797
3MP0008058_abnormal_DNA_repair2.93402135
4MP0006072_abnormal_retinal_apoptosis2.55291985
5MP0010094_abnormal_chromosome_stability2.46931549
6MP0008877_abnormal_DNA_methylation2.38032233
7MP0003806_abnormal_nucleotide_metabolis2.25812093
8MP0005645_abnormal_hypothalamus_physiol2.24147371
9MP0008875_abnormal_xenobiotic_pharmacok2.20467706
10MP0001835_abnormal_antigen_presentation2.15822756
11MP0003693_abnormal_embryo_hatching2.14285230
12MP0005084_abnormal_gallbladder_morpholo2.13313222
13MP0009697_abnormal_copulation2.07967010
14MP0002837_dystrophic_cardiac_calcinosis2.07569986
15MP0002254_reproductive_system_inflammat2.04320376
16MP0003786_premature_aging1.96481419
17MP0008872_abnormal_physiological_respon1.96187119
18MP0003718_maternal_effect1.95954725
19MP0000372_irregular_coat_pigmentation1.88098817
20MP0004957_abnormal_blastocyst_morpholog1.82697304
21MP0009785_altered_susceptibility_to1.81248430
22MP0008007_abnormal_cellular_replicative1.77583636
23MP0004147_increased_porphyrin_level1.75284869
24MP0001188_hyperpigmentation1.71227706
25MP0003011_delayed_dark_adaptation1.71050276
26MP0002166_altered_tumor_susceptibility1.63635207
27MP0006035_abnormal_mitochondrial_morpho1.57677683
28MP0002138_abnormal_hepatobiliary_system1.57489097
29MP0005551_abnormal_eye_electrophysiolog1.53841497
30MP0006036_abnormal_mitochondrial_physio1.53674736
31MP0002006_tumorigenesis1.53526855
32MP0002736_abnormal_nociception_after1.50110588
33MP0003195_calcinosis1.49161394
34MP0005253_abnormal_eye_physiology1.47575227
35MP0001529_abnormal_vocalization1.43984824
36MP0002148_abnormal_hypersensitivity_rea1.40850332
37MP0001968_abnormal_touch/_nociception1.38397429
38MP0001984_abnormal_olfaction1.36238983
39MP0005075_abnormal_melanosome_morpholog1.36220224
40MP0002876_abnormal_thyroid_physiology1.29371438
41MP0000685_abnormal_immune_system1.27785330
42MP0001905_abnormal_dopamine_level1.26571638
43MP0004142_abnormal_muscle_tone1.24268155
44MP0003567_abnormal_fetal_cardiomyocyte1.24257603
45MP0009333_abnormal_splenocyte_physiolog1.22080249
46MP0002277_abnormal_respiratory_mucosa1.20169327
47MP0003186_abnormal_redox_activity1.20067149
48MP0005387_immune_system_phenotype1.17020734
49MP0001790_abnormal_immune_system1.17020734
50MP0001873_stomach_inflammation1.15461004
51MP0005410_abnormal_fertilization1.12109111
52MP0002272_abnormal_nervous_system1.09807507
53MP0001501_abnormal_sleep_pattern1.09532927
54MP0003763_abnormal_thymus_physiology1.06998583
55MP0001800_abnormal_humoral_immune1.05090948
56MP0003137_abnormal_impulse_conducting1.04932643
57MP0005646_abnormal_pituitary_gland1.04186762
58MP0004215_abnormal_myocardial_fiber1.03143478
59MP0003077_abnormal_cell_cycle1.03039476
60MP0001764_abnormal_homeostasis1.02541286
61MP0001485_abnormal_pinna_reflex1.02178164
62MP0005636_abnormal_mineral_homeostasis1.01049176
63MP0004145_abnormal_muscle_electrophysio0.96447122
64MP0005389_reproductive_system_phenotype0.95474951
65MP0003111_abnormal_nucleus_morphology0.95054345
66MP0009764_decreased_sensitivity_to0.94691463
67MP0002160_abnormal_reproductive_system0.94373239
68MP0001929_abnormal_gametogenesis0.93747209
69MP0003880_abnormal_central_pattern0.92914881
70MP0005332_abnormal_amino_acid0.92768145
71MP0005379_endocrine/exocrine_gland_phen0.91960628
72MP0001986_abnormal_taste_sensitivity0.91538333
73MP0005085_abnormal_gallbladder_physiolo0.91067938
74MP0006276_abnormal_autonomic_nervous0.90851772
75MP0002420_abnormal_adaptive_immunity0.89850691
76MP0002723_abnormal_immune_serum0.89526326
77MP0005167_abnormal_blood-brain_barrier0.88942489
78MP0005000_abnormal_immune_tolerance0.88925565
79MP0001819_abnormal_immune_cell0.88411439
80MP0000689_abnormal_spleen_morphology0.87922150
81MP0002751_abnormal_autonomic_nervous0.87134751
82MP0004043_abnormal_pH_regulation0.84737991
83MP0008995_early_reproductive_senescence0.84411760
84MP0009046_muscle_twitch0.84316142
85MP0008932_abnormal_embryonic_tissue0.83469296
86MP0002210_abnormal_sex_determination0.80390145
87MP0004885_abnormal_endolymph0.78429703
88MP0005367_renal/urinary_system_phenotyp0.77951695
89MP0000516_abnormal_urinary_system0.77951695
90MP0002452_abnormal_antigen_presenting0.76367513
91MP0002163_abnormal_gland_morphology0.76299975
92MP0002398_abnormal_bone_marrow0.75370779
93MP0003890_abnormal_embryonic-extraembry0.75135720
94MP0006292_abnormal_olfactory_placode0.74832710
95MP0009745_abnormal_behavioral_response0.73962681
96MP0001919_abnormal_reproductive_system0.71820818
97MP0003866_abnormal_defecation0.71447846
98MP0000703_abnormal_thymus_morphology0.71442950
99MP0000653_abnormal_sex_gland0.70998748
100MP0002693_abnormal_pancreas_physiology0.68521046

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.93510294
2Methylmalonic acidemia (HP:0002912)3.58612111
3Increased CSF lactate (HP:0002490)3.57681561
4Acute encephalopathy (HP:0006846)3.54705182
5Mitochondrial inheritance (HP:0001427)3.49737879
6Progressive macrocephaly (HP:0004481)3.41837929
7Abnormal mitochondria in muscle tissue (HP:0008316)3.36303697
8Increased hepatocellular lipid droplets (HP:0006565)3.30559172
9IgG deficiency (HP:0004315)3.30082027
10Lipid accumulation in hepatocytes (HP:0006561)3.23641238
11Stomatitis (HP:0010280)3.13603287
123-Methylglutaconic aciduria (HP:0003535)3.12292205
13Hepatocellular necrosis (HP:0001404)3.08590625
14Methylmalonic aciduria (HP:0012120)3.04905421
15Hypoproteinemia (HP:0003075)2.98358797
16Increased serum lactate (HP:0002151)2.98068419
17Hepatic necrosis (HP:0002605)2.91274293
18Cerebral edema (HP:0002181)2.88404391
19Aplastic anemia (HP:0001915)2.81686131
20Abnormality of alanine metabolism (HP:0010916)2.79471979
21Hyperalaninemia (HP:0003348)2.79471979
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79471979
23Hypothermia (HP:0002045)2.65614536
24Type I transferrin isoform profile (HP:0003642)2.64672808
25Renal Fanconi syndrome (HP:0001994)2.63463516
26Lactic acidosis (HP:0003128)2.58192620
27Pancreatic cysts (HP:0001737)2.57296957
28Abnormality of the labia minora (HP:0012880)2.56469804
29Abolished electroretinogram (ERG) (HP:0000550)2.47003737
30Congenital stationary night blindness (HP:0007642)2.44167506
31Decreased electroretinogram (ERG) amplitude (HP:0000654)2.41483108
32Molar tooth sign on MRI (HP:0002419)2.39243480
33Abnormality of midbrain morphology (HP:0002418)2.39243480
34Lethargy (HP:0001254)2.38263655
35Abnormality of methionine metabolism (HP:0010901)2.38169397
36Congenital, generalized hypertrichosis (HP:0004540)2.35155889
37Abnormality of vitamin B metabolism (HP:0004340)2.32393709
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30303178
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.29227328
40Optic disc pallor (HP:0000543)2.28990043
41Abnormality of the vitamin B12 metabolism (HP:0004341)2.25990107
42Severe combined immunodeficiency (HP:0004430)2.24600728
43Abnormality of B cell number (HP:0010975)2.24044268
44Abnormality of macular pigmentation (HP:0008002)2.23890679
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21735234
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21735234
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20611466
48True hermaphroditism (HP:0010459)2.20102414
49Pancreatic fibrosis (HP:0100732)2.18750481
50Nephronophthisis (HP:0000090)2.18322895
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17894076
52Abnormal protein N-linked glycosylation (HP:0012347)2.17894076
53Abnormal protein glycosylation (HP:0012346)2.17894076
54Abnormal glycosylation (HP:0012345)2.17894076
55Degeneration of anterior horn cells (HP:0002398)2.17633399
56Abnormality of the anterior horn cell (HP:0006802)2.17633399
57Colon cancer (HP:0003003)2.15269204
58Renal cortical cysts (HP:0000803)2.15052446
59B lymphocytopenia (HP:0010976)2.13358488
60Abnormality of the pons (HP:0007361)2.12756228
61Oral leukoplakia (HP:0002745)2.11963438
62Increased serum pyruvate (HP:0003542)2.09417994
63Type 2 muscle fiber atrophy (HP:0003554)2.09415170
64Respiratory failure (HP:0002878)2.05836268
65Increased intramyocellular lipid droplets (HP:0012240)2.05636817
66Exertional dyspnea (HP:0002875)2.05364475
67Thyroiditis (HP:0100646)2.05203854
68Attenuation of retinal blood vessels (HP:0007843)2.04931846
69Abnormality of serum amino acid levels (HP:0003112)2.04410211
70Pancytopenia (HP:0001876)2.03978110
71Hyperglycinuria (HP:0003108)2.02746240
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01773468
73Dicarboxylic aciduria (HP:0003215)2.01773468
74Hypoplasia of the pons (HP:0012110)1.99023847
75Palpitations (HP:0001962)1.97823350
76Abnormality of the prostate (HP:0008775)1.92516208
77Neoplasm of the adrenal gland (HP:0100631)1.91359149
78Abnormality of glycine metabolism (HP:0010895)1.90529278
79Abnormality of serine family amino acid metabolism (HP:0010894)1.90529278
80Meckel diverticulum (HP:0002245)1.89824352
81Abnormality of the renal cortex (HP:0011035)1.87055314
82Progressive inability to walk (HP:0002505)1.85944215
83Pendular nystagmus (HP:0012043)1.85869673
84Hypomagnesemia (HP:0002917)1.84298779
85Generalized aminoaciduria (HP:0002909)1.84135036
86Decreased central vision (HP:0007663)1.83703891
87Megaloblastic anemia (HP:0001889)1.83607317
88Glycosuria (HP:0003076)1.83003745
89Abnormality of urine glucose concentration (HP:0011016)1.83003745
90Abnormality of the ileum (HP:0001549)1.82655539
91Constricted visual fields (HP:0001133)1.81882858
92Reduced antithrombin III activity (HP:0001976)1.80673373
93Exercise intolerance (HP:0003546)1.80392148
94Leukodystrophy (HP:0002415)1.80243572
95Abnormality of homocysteine metabolism (HP:0010919)1.79973410
96Homocystinuria (HP:0002156)1.79973410
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.79168492
98Increased IgM level (HP:0003496)1.78121003
99Type II lissencephaly (HP:0007260)1.77989244
100T lymphocytopenia (HP:0005403)1.77883005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.09018802
2MAP4K23.46079773
3EIF2AK33.38426877
4VRK22.65744040
5MST42.62879394
6ZAK2.45339317
7NUAK12.38348217
8TRIM282.33424707
9TXK2.16934296
10NEK12.16649993
11EIF2AK12.12177846
12SRPK12.10932061
13VRK11.98218916
14WNK31.97939779
15BCKDK1.97602201
16BUB11.92512184
17TLK11.90740373
18PLK31.75374204
19TAOK31.75289610
20FRK1.72351665
21ADRBK21.70064651
22MKNK11.69092631
23TAF11.67160801
24MKNK21.66945545
25BMPR1B1.62244732
26GRK11.54313980
27TIE11.49609619
28PLK41.43001193
29BCR1.39684281
30MAP3K121.32999801
31CSNK1G31.26737215
32CSNK1G21.20876494
33TEC1.16245069
34PASK1.14764129
35CSNK1G11.14569654
36ERBB31.11595277
37STK161.05326056
38KDR1.04645403
39WNK41.04295337
40CSNK1A1L1.01699940
41PBK0.99978839
42PLK20.99103746
43MAP3K40.98127887
44OXSR10.98086780
45INSRR0.95348576
46EIF2AK20.95117743
47PINK10.94177827
48ACVR1B0.90183825
49NME10.85644700
50CDC70.85292513
51WEE10.81806458
52RPS6KA40.75973200
53ITK0.75414462
54MAPKAPK50.71986426
55TTK0.71543654
56CDK190.71383729
57STK390.69718491
58MAP2K70.68919234
59RPS6KA50.68294939
60DAPK10.66436553
61DYRK20.62778383
62PLK10.62678126
63SIK30.61799753
64MAP4K10.59293649
65MAP2K60.59055757
66PIM20.58938074
67MAPK130.57771179
68ALK0.54356447
69PRKCE0.52361585
70IKBKB0.50604933
71TGFBR10.49913080
72ATR0.49889593
73PRKCQ0.48844646
74TNIK0.48384849
75PHKG10.47796387
76PHKG20.47796387
77BRSK20.47082607
78KIT0.43731449
79LIMK10.39756296
80FLT30.37954314
81CSNK2A10.37792600
82FES0.37550822
83CLK10.37444447
84CSNK2A20.36229964
85STK38L0.35276147
86IKBKE0.34248498
87SYK0.34179792
88ATM0.33270357
89CDK80.32610733
90MINK10.30925208
91ADRBK10.30411112
92CSNK1A10.30219188
93TESK10.30141114
94PDK20.29454758
95DAPK20.29280138
96AURKB0.29247791
97PRKCI0.27986781
98PRKCG0.27596875
99CAMK2A0.26312671
100LCK0.25874099

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.94223135
2Protein export_Homo sapiens_hsa030603.41247306
3Oxidative phosphorylation_Homo sapiens_hsa001902.91058754
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.80359567
5RNA polymerase_Homo sapiens_hsa030202.72709528
6Parkinsons disease_Homo sapiens_hsa050122.51307586
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06907598
8RNA degradation_Homo sapiens_hsa030181.94827695
9Propanoate metabolism_Homo sapiens_hsa006401.92928340
10Primary immunodeficiency_Homo sapiens_hsa053401.86222605
11Mismatch repair_Homo sapiens_hsa034301.85005645
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83466355
13Non-homologous end-joining_Homo sapiens_hsa034501.82763415
14Basal transcription factors_Homo sapiens_hsa030221.82620462
15Caffeine metabolism_Homo sapiens_hsa002321.75209283
16One carbon pool by folate_Homo sapiens_hsa006701.73719420
17Homologous recombination_Homo sapiens_hsa034401.72834702
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64287215
19RNA transport_Homo sapiens_hsa030131.64210536
20Asthma_Homo sapiens_hsa053101.62704691
21Spliceosome_Homo sapiens_hsa030401.61280063
22Huntingtons disease_Homo sapiens_hsa050161.59241242
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58095023
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55133829
25Alzheimers disease_Homo sapiens_hsa050101.50196070
26Allograft rejection_Homo sapiens_hsa053301.49773421
27Type I diabetes mellitus_Homo sapiens_hsa049401.47399036
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41605168
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.40699556
30Autoimmune thyroid disease_Homo sapiens_hsa053201.39903029
31Sulfur metabolism_Homo sapiens_hsa009201.39357867
32DNA replication_Homo sapiens_hsa030301.35132517
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28443372
34Butanoate metabolism_Homo sapiens_hsa006501.25725919
35Pyrimidine metabolism_Homo sapiens_hsa002401.24564845
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21240739
37Fanconi anemia pathway_Homo sapiens_hsa034601.20894863
38Antigen processing and presentation_Homo sapiens_hsa046121.20307471
39Phototransduction_Homo sapiens_hsa047441.20152702
40Linoleic acid metabolism_Homo sapiens_hsa005911.18285580
41Nucleotide excision repair_Homo sapiens_hsa034201.17902430
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15795946
43Purine metabolism_Homo sapiens_hsa002301.15580287
44Steroid biosynthesis_Homo sapiens_hsa001001.09201863
45Fatty acid elongation_Homo sapiens_hsa000621.08560078
46Base excision repair_Homo sapiens_hsa034101.07721639
47Vitamin B6 metabolism_Homo sapiens_hsa007501.06095481
48Ribosome_Homo sapiens_hsa030101.04722571
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03874775
50Selenocompound metabolism_Homo sapiens_hsa004501.00114246
51Graft-versus-host disease_Homo sapiens_hsa053320.99972144
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99015820
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.97347997
54Peroxisome_Homo sapiens_hsa041460.97073762
55Pyruvate metabolism_Homo sapiens_hsa006200.95679060
56Tryptophan metabolism_Homo sapiens_hsa003800.95513926
57Ether lipid metabolism_Homo sapiens_hsa005650.87801821
58Collecting duct acid secretion_Homo sapiens_hsa049660.83886239
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.83351436
60Regulation of autophagy_Homo sapiens_hsa041400.79834523
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77222932
62Cardiac muscle contraction_Homo sapiens_hsa042600.74613041
63Rheumatoid arthritis_Homo sapiens_hsa053230.71281601
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70150257
65Metabolic pathways_Homo sapiens_hsa011000.68742574
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68741896
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65991544
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63606904
69Folate biosynthesis_Homo sapiens_hsa007900.61719003
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60757861
71Hematopoietic cell lineage_Homo sapiens_hsa046400.57793162
72Glutathione metabolism_Homo sapiens_hsa004800.57577108
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54157876
74Chemical carcinogenesis_Homo sapiens_hsa052040.52550680
75Legionellosis_Homo sapiens_hsa051340.52410945
76Epstein-Barr virus infection_Homo sapiens_hsa051690.51359587
77Arachidonic acid metabolism_Homo sapiens_hsa005900.49743490
78Fatty acid metabolism_Homo sapiens_hsa012120.49041370
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48294569
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48143980
81mRNA surveillance pathway_Homo sapiens_hsa030150.47833747
82Fatty acid degradation_Homo sapiens_hsa000710.46703386
83Retinol metabolism_Homo sapiens_hsa008300.44226695
84Carbon metabolism_Homo sapiens_hsa012000.42759362
85Sulfur relay system_Homo sapiens_hsa041220.41903313
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41876375
87beta-Alanine metabolism_Homo sapiens_hsa004100.41065727
88Nitrogen metabolism_Homo sapiens_hsa009100.40835316
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37600799
90Olfactory transduction_Homo sapiens_hsa047400.36065128
91Fat digestion and absorption_Homo sapiens_hsa049750.35937052
92Vitamin digestion and absorption_Homo sapiens_hsa049770.35690025
93N-Glycan biosynthesis_Homo sapiens_hsa005100.35522716
94Cell cycle_Homo sapiens_hsa041100.35231008
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32194649
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.31104895
97Oocyte meiosis_Homo sapiens_hsa041140.31069635
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30516299
99Measles_Homo sapiens_hsa051620.28434588
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27325684

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