

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.45962358 |
| 2 | proteasome assembly (GO:0043248) | 5.00504430 |
| 3 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.77444658 |
| 4 | protein neddylation (GO:0045116) | 4.75213944 |
| 5 | DNA double-strand break processing (GO:0000729) | 4.19810215 |
| 6 | cullin deneddylation (GO:0010388) | 4.17420398 |
| 7 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.16465824 |
| 8 | rRNA modification (GO:0000154) | 4.07782931 |
| 9 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.01548396 |
| 10 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.94537962 |
| 11 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.94198726 |
| 12 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.86992136 |
| 13 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.80761646 |
| 14 | pseudouridine synthesis (GO:0001522) | 3.80643514 |
| 15 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.80284139 |
| 16 | ATP synthesis coupled proton transport (GO:0015986) | 3.80284139 |
| 17 | protein deneddylation (GO:0000338) | 3.78349666 |
| 18 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.75984646 |
| 19 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.74584119 |
| 20 | negative regulation of ligase activity (GO:0051352) | 3.72268075 |
| 21 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.72268075 |
| 22 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.69475805 |
| 23 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.69475805 |
| 24 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.69475805 |
| 25 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.65662864 |
| 26 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.65662864 |
| 27 | rRNA methylation (GO:0031167) | 3.64984703 |
| 28 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.62232718 |
| 29 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.62232718 |
| 30 | termination of RNA polymerase III transcription (GO:0006386) | 3.59277519 |
| 31 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.59277519 |
| 32 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.58027115 |
| 33 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.51929807 |
| 34 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.51929807 |
| 35 | maturation of 5.8S rRNA (GO:0000460) | 3.51726844 |
| 36 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.48664427 |
| 37 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.42785581 |
| 38 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.40599239 |
| 39 | DNA damage response, detection of DNA damage (GO:0042769) | 3.40306791 |
| 40 | platelet dense granule organization (GO:0060155) | 3.39739027 |
| 41 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.38831157 |
| 42 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.35287675 |
| 43 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.35287675 |
| 44 | isotype switching (GO:0045190) | 3.35287675 |
| 45 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.34050346 |
| 46 | respiratory chain complex IV assembly (GO:0008535) | 3.33363888 |
| 47 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.30634017 |
| 48 | chaperone-mediated protein transport (GO:0072321) | 3.24806434 |
| 49 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.22957526 |
| 50 | ribosome assembly (GO:0042255) | 3.21285839 |
| 51 | protein complex biogenesis (GO:0070271) | 3.21165423 |
| 52 | cytidine metabolic process (GO:0046087) | 3.20216535 |
| 53 | cytidine catabolic process (GO:0006216) | 3.20216535 |
| 54 | cytidine deamination (GO:0009972) | 3.20216535 |
| 55 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.18927504 |
| 56 | tRNA processing (GO:0008033) | 3.16884577 |
| 57 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.15207491 |
| 58 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.15207491 |
| 59 | mannosylation (GO:0097502) | 3.14188349 |
| 60 | positive regulation of ligase activity (GO:0051351) | 3.13084228 |
| 61 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.05753045 |
| 62 | peptidyl-histidine modification (GO:0018202) | 3.00000677 |
| 63 | protein-cofactor linkage (GO:0018065) | 2.99535872 |
| 64 | mitochondrial RNA metabolic process (GO:0000959) | 2.98185709 |
| 65 | tRNA metabolic process (GO:0006399) | 2.96800030 |
| 66 | purine nucleobase biosynthetic process (GO:0009113) | 2.95599255 |
| 67 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.94424521 |
| 68 | NADH dehydrogenase complex assembly (GO:0010257) | 2.94424521 |
| 69 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.94424521 |
| 70 | histone mRNA metabolic process (GO:0008334) | 2.94048507 |
| 71 | IMP biosynthetic process (GO:0006188) | 2.91211912 |
| 72 | cytochrome complex assembly (GO:0017004) | 2.91206210 |
| 73 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.89504812 |
| 74 | regulation of cellular amine metabolic process (GO:0033238) | 2.87898695 |
| 75 | spliceosomal snRNP assembly (GO:0000387) | 2.87429344 |
| 76 | inner mitochondrial membrane organization (GO:0007007) | 2.87124338 |
| 77 | protein refolding (GO:0042026) | 2.85240811 |
| 78 | respiratory electron transport chain (GO:0022904) | 2.83660697 |
| 79 | positive regulation of cell cycle arrest (GO:0071158) | 2.83412512 |
| 80 | electron transport chain (GO:0022900) | 2.82455868 |
| 81 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.80275903 |
| 82 | nucleobase biosynthetic process (GO:0046112) | 2.79532594 |
| 83 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.77245806 |
| 84 | DNA replication checkpoint (GO:0000076) | 2.75623570 |
| 85 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.74949267 |
| 86 | tRNA modification (GO:0006400) | 2.73850873 |
| 87 | intracellular protein transmembrane import (GO:0044743) | 2.73208155 |
| 88 | branched-chain amino acid catabolic process (GO:0009083) | 2.73017783 |
| 89 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.72040164 |
| 90 | regulation of ligase activity (GO:0051340) | 2.70984951 |
| 91 | chromatin remodeling at centromere (GO:0031055) | 2.70676116 |
| 92 | negative regulation of protein ubiquitination (GO:0031397) | 2.70515935 |
| 93 | negative regulation of telomere maintenance (GO:0032205) | 2.70190113 |
| 94 | L-fucose catabolic process (GO:0042355) | 2.69458735 |
| 95 | fucose catabolic process (GO:0019317) | 2.69458735 |
| 96 | L-fucose metabolic process (GO:0042354) | 2.69458735 |
| 97 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.68355792 |
| 98 | protein localization to mitochondrion (GO:0070585) | 2.67738269 |
| 99 | CENP-A containing nucleosome assembly (GO:0034080) | 2.66956381 |
| 100 | protein targeting to mitochondrion (GO:0006626) | 2.65502550 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.00804119 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.46733552 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.75540085 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.31458318 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.09581809 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.96195929 |
| 7 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.95430589 |
| 8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.91776984 |
| 9 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.89146850 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.82134678 |
| 11 | VDR_22108803_ChIP-Seq_LS180_Human | 2.80618449 |
| 12 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.77615729 |
| 13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.58913764 |
| 14 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.58420722 |
| 15 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.45034343 |
| 16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.42736575 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.42548899 |
| 18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.39241322 |
| 19 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.27732317 |
| 20 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.18835464 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.16750431 |
| 22 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.13782151 |
| 23 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.02174249 |
| 24 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.96576274 |
| 25 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.93545377 |
| 26 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.89122701 |
| 27 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.87023840 |
| 28 | EWS_26573619_Chip-Seq_HEK293_Human | 1.86099454 |
| 29 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.85433359 |
| 30 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.83738597 |
| 31 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.73844254 |
| 32 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.67636784 |
| 33 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.65573763 |
| 34 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.57565739 |
| 35 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.56673520 |
| 36 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.56295600 |
| 37 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.51410794 |
| 38 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.51153824 |
| 39 | FUS_26573619_Chip-Seq_HEK293_Human | 1.50465783 |
| 40 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.49749993 |
| 41 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.49652353 |
| 42 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.48197981 |
| 43 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.42069966 |
| 44 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.41156881 |
| 45 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.40890645 |
| 46 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.35635802 |
| 47 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.33994673 |
| 48 | P300_19829295_ChIP-Seq_ESCs_Human | 1.29393531 |
| 49 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.28946671 |
| 50 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.28555488 |
| 51 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.22997884 |
| 52 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.22273965 |
| 53 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.21042986 |
| 54 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.19666436 |
| 55 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.19406039 |
| 56 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.18808521 |
| 57 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.17898795 |
| 58 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.14947248 |
| 59 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.13487048 |
| 60 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.13487048 |
| 61 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.13464439 |
| 62 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.12781137 |
| 63 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.11110940 |
| 64 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.09008985 |
| 65 | GATA3_26560356_Chip-Seq_TH2_Human | 1.09008962 |
| 66 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.06716383 |
| 67 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.05657727 |
| 68 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.05657727 |
| 69 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.04843518 |
| 70 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.04720708 |
| 71 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.03978960 |
| 72 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.03171794 |
| 73 | AR_20517297_ChIP-Seq_VCAP_Human | 1.02776921 |
| 74 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.02665464 |
| 75 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.02267419 |
| 76 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.02069501 |
| 77 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.00552871 |
| 78 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.98946433 |
| 79 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.98717343 |
| 80 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.96825771 |
| 81 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.95671675 |
| 82 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.95302977 |
| 83 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.93995167 |
| 84 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.93669869 |
| 85 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.93396825 |
| 86 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.92855558 |
| 87 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.92760998 |
| 88 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.91903326 |
| 89 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.91704759 |
| 90 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.91704759 |
| 91 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.91531505 |
| 92 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.90761689 |
| 93 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.90073646 |
| 94 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.89911346 |
| 95 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.86866398 |
| 96 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.86684488 |
| 97 | NCOR_22424771_ChIP-Seq_293T_Human | 0.86547237 |
| 98 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.85627787 |
| 99 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.85335255 |
| 100 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.85226506 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 3.07119208 |
| 2 | MP0002102_abnormal_ear_morphology | 3.01275797 |
| 3 | MP0008058_abnormal_DNA_repair | 2.93402135 |
| 4 | MP0006072_abnormal_retinal_apoptosis | 2.55291985 |
| 5 | MP0010094_abnormal_chromosome_stability | 2.46931549 |
| 6 | MP0008877_abnormal_DNA_methylation | 2.38032233 |
| 7 | MP0003806_abnormal_nucleotide_metabolis | 2.25812093 |
| 8 | MP0005645_abnormal_hypothalamus_physiol | 2.24147371 |
| 9 | MP0008875_abnormal_xenobiotic_pharmacok | 2.20467706 |
| 10 | MP0001835_abnormal_antigen_presentation | 2.15822756 |
| 11 | MP0003693_abnormal_embryo_hatching | 2.14285230 |
| 12 | MP0005084_abnormal_gallbladder_morpholo | 2.13313222 |
| 13 | MP0009697_abnormal_copulation | 2.07967010 |
| 14 | MP0002837_dystrophic_cardiac_calcinosis | 2.07569986 |
| 15 | MP0002254_reproductive_system_inflammat | 2.04320376 |
| 16 | MP0003786_premature_aging | 1.96481419 |
| 17 | MP0008872_abnormal_physiological_respon | 1.96187119 |
| 18 | MP0003718_maternal_effect | 1.95954725 |
| 19 | MP0000372_irregular_coat_pigmentation | 1.88098817 |
| 20 | MP0004957_abnormal_blastocyst_morpholog | 1.82697304 |
| 21 | MP0009785_altered_susceptibility_to | 1.81248430 |
| 22 | MP0008007_abnormal_cellular_replicative | 1.77583636 |
| 23 | MP0004147_increased_porphyrin_level | 1.75284869 |
| 24 | MP0001188_hyperpigmentation | 1.71227706 |
| 25 | MP0003011_delayed_dark_adaptation | 1.71050276 |
| 26 | MP0002166_altered_tumor_susceptibility | 1.63635207 |
| 27 | MP0006035_abnormal_mitochondrial_morpho | 1.57677683 |
| 28 | MP0002138_abnormal_hepatobiliary_system | 1.57489097 |
| 29 | MP0005551_abnormal_eye_electrophysiolog | 1.53841497 |
| 30 | MP0006036_abnormal_mitochondrial_physio | 1.53674736 |
| 31 | MP0002006_tumorigenesis | 1.53526855 |
| 32 | MP0002736_abnormal_nociception_after | 1.50110588 |
| 33 | MP0003195_calcinosis | 1.49161394 |
| 34 | MP0005253_abnormal_eye_physiology | 1.47575227 |
| 35 | MP0001529_abnormal_vocalization | 1.43984824 |
| 36 | MP0002148_abnormal_hypersensitivity_rea | 1.40850332 |
| 37 | MP0001968_abnormal_touch/_nociception | 1.38397429 |
| 38 | MP0001984_abnormal_olfaction | 1.36238983 |
| 39 | MP0005075_abnormal_melanosome_morpholog | 1.36220224 |
| 40 | MP0002876_abnormal_thyroid_physiology | 1.29371438 |
| 41 | MP0000685_abnormal_immune_system | 1.27785330 |
| 42 | MP0001905_abnormal_dopamine_level | 1.26571638 |
| 43 | MP0004142_abnormal_muscle_tone | 1.24268155 |
| 44 | MP0003567_abnormal_fetal_cardiomyocyte | 1.24257603 |
| 45 | MP0009333_abnormal_splenocyte_physiolog | 1.22080249 |
| 46 | MP0002277_abnormal_respiratory_mucosa | 1.20169327 |
| 47 | MP0003186_abnormal_redox_activity | 1.20067149 |
| 48 | MP0005387_immune_system_phenotype | 1.17020734 |
| 49 | MP0001790_abnormal_immune_system | 1.17020734 |
| 50 | MP0001873_stomach_inflammation | 1.15461004 |
| 51 | MP0005410_abnormal_fertilization | 1.12109111 |
| 52 | MP0002272_abnormal_nervous_system | 1.09807507 |
| 53 | MP0001501_abnormal_sleep_pattern | 1.09532927 |
| 54 | MP0003763_abnormal_thymus_physiology | 1.06998583 |
| 55 | MP0001800_abnormal_humoral_immune | 1.05090948 |
| 56 | MP0003137_abnormal_impulse_conducting | 1.04932643 |
| 57 | MP0005646_abnormal_pituitary_gland | 1.04186762 |
| 58 | MP0004215_abnormal_myocardial_fiber | 1.03143478 |
| 59 | MP0003077_abnormal_cell_cycle | 1.03039476 |
| 60 | MP0001764_abnormal_homeostasis | 1.02541286 |
| 61 | MP0001485_abnormal_pinna_reflex | 1.02178164 |
| 62 | MP0005636_abnormal_mineral_homeostasis | 1.01049176 |
| 63 | MP0004145_abnormal_muscle_electrophysio | 0.96447122 |
| 64 | MP0005389_reproductive_system_phenotype | 0.95474951 |
| 65 | MP0003111_abnormal_nucleus_morphology | 0.95054345 |
| 66 | MP0009764_decreased_sensitivity_to | 0.94691463 |
| 67 | MP0002160_abnormal_reproductive_system | 0.94373239 |
| 68 | MP0001929_abnormal_gametogenesis | 0.93747209 |
| 69 | MP0003880_abnormal_central_pattern | 0.92914881 |
| 70 | MP0005332_abnormal_amino_acid | 0.92768145 |
| 71 | MP0005379_endocrine/exocrine_gland_phen | 0.91960628 |
| 72 | MP0001986_abnormal_taste_sensitivity | 0.91538333 |
| 73 | MP0005085_abnormal_gallbladder_physiolo | 0.91067938 |
| 74 | MP0006276_abnormal_autonomic_nervous | 0.90851772 |
| 75 | MP0002420_abnormal_adaptive_immunity | 0.89850691 |
| 76 | MP0002723_abnormal_immune_serum | 0.89526326 |
| 77 | MP0005167_abnormal_blood-brain_barrier | 0.88942489 |
| 78 | MP0005000_abnormal_immune_tolerance | 0.88925565 |
| 79 | MP0001819_abnormal_immune_cell | 0.88411439 |
| 80 | MP0000689_abnormal_spleen_morphology | 0.87922150 |
| 81 | MP0002751_abnormal_autonomic_nervous | 0.87134751 |
| 82 | MP0004043_abnormal_pH_regulation | 0.84737991 |
| 83 | MP0008995_early_reproductive_senescence | 0.84411760 |
| 84 | MP0009046_muscle_twitch | 0.84316142 |
| 85 | MP0008932_abnormal_embryonic_tissue | 0.83469296 |
| 86 | MP0002210_abnormal_sex_determination | 0.80390145 |
| 87 | MP0004885_abnormal_endolymph | 0.78429703 |
| 88 | MP0005367_renal/urinary_system_phenotyp | 0.77951695 |
| 89 | MP0000516_abnormal_urinary_system | 0.77951695 |
| 90 | MP0002452_abnormal_antigen_presenting | 0.76367513 |
| 91 | MP0002163_abnormal_gland_morphology | 0.76299975 |
| 92 | MP0002398_abnormal_bone_marrow | 0.75370779 |
| 93 | MP0003890_abnormal_embryonic-extraembry | 0.75135720 |
| 94 | MP0006292_abnormal_olfactory_placode | 0.74832710 |
| 95 | MP0009745_abnormal_behavioral_response | 0.73962681 |
| 96 | MP0001919_abnormal_reproductive_system | 0.71820818 |
| 97 | MP0003866_abnormal_defecation | 0.71447846 |
| 98 | MP0000703_abnormal_thymus_morphology | 0.71442950 |
| 99 | MP0000653_abnormal_sex_gland | 0.70998748 |
| 100 | MP0002693_abnormal_pancreas_physiology | 0.68521046 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 3.93510294 |
| 2 | Methylmalonic acidemia (HP:0002912) | 3.58612111 |
| 3 | Increased CSF lactate (HP:0002490) | 3.57681561 |
| 4 | Acute encephalopathy (HP:0006846) | 3.54705182 |
| 5 | Mitochondrial inheritance (HP:0001427) | 3.49737879 |
| 6 | Progressive macrocephaly (HP:0004481) | 3.41837929 |
| 7 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.36303697 |
| 8 | Increased hepatocellular lipid droplets (HP:0006565) | 3.30559172 |
| 9 | IgG deficiency (HP:0004315) | 3.30082027 |
| 10 | Lipid accumulation in hepatocytes (HP:0006561) | 3.23641238 |
| 11 | Stomatitis (HP:0010280) | 3.13603287 |
| 12 | 3-Methylglutaconic aciduria (HP:0003535) | 3.12292205 |
| 13 | Hepatocellular necrosis (HP:0001404) | 3.08590625 |
| 14 | Methylmalonic aciduria (HP:0012120) | 3.04905421 |
| 15 | Hypoproteinemia (HP:0003075) | 2.98358797 |
| 16 | Increased serum lactate (HP:0002151) | 2.98068419 |
| 17 | Hepatic necrosis (HP:0002605) | 2.91274293 |
| 18 | Cerebral edema (HP:0002181) | 2.88404391 |
| 19 | Aplastic anemia (HP:0001915) | 2.81686131 |
| 20 | Abnormality of alanine metabolism (HP:0010916) | 2.79471979 |
| 21 | Hyperalaninemia (HP:0003348) | 2.79471979 |
| 22 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.79471979 |
| 23 | Hypothermia (HP:0002045) | 2.65614536 |
| 24 | Type I transferrin isoform profile (HP:0003642) | 2.64672808 |
| 25 | Renal Fanconi syndrome (HP:0001994) | 2.63463516 |
| 26 | Lactic acidosis (HP:0003128) | 2.58192620 |
| 27 | Pancreatic cysts (HP:0001737) | 2.57296957 |
| 28 | Abnormality of the labia minora (HP:0012880) | 2.56469804 |
| 29 | Abolished electroretinogram (ERG) (HP:0000550) | 2.47003737 |
| 30 | Congenital stationary night blindness (HP:0007642) | 2.44167506 |
| 31 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.41483108 |
| 32 | Molar tooth sign on MRI (HP:0002419) | 2.39243480 |
| 33 | Abnormality of midbrain morphology (HP:0002418) | 2.39243480 |
| 34 | Lethargy (HP:0001254) | 2.38263655 |
| 35 | Abnormality of methionine metabolism (HP:0010901) | 2.38169397 |
| 36 | Congenital, generalized hypertrichosis (HP:0004540) | 2.35155889 |
| 37 | Abnormality of vitamin B metabolism (HP:0004340) | 2.32393709 |
| 38 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.30303178 |
| 39 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.29227328 |
| 40 | Optic disc pallor (HP:0000543) | 2.28990043 |
| 41 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.25990107 |
| 42 | Severe combined immunodeficiency (HP:0004430) | 2.24600728 |
| 43 | Abnormality of B cell number (HP:0010975) | 2.24044268 |
| 44 | Abnormality of macular pigmentation (HP:0008002) | 2.23890679 |
| 45 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.21735234 |
| 46 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.21735234 |
| 47 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.20611466 |
| 48 | True hermaphroditism (HP:0010459) | 2.20102414 |
| 49 | Pancreatic fibrosis (HP:0100732) | 2.18750481 |
| 50 | Nephronophthisis (HP:0000090) | 2.18322895 |
| 51 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.17894076 |
| 52 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.17894076 |
| 53 | Abnormal protein glycosylation (HP:0012346) | 2.17894076 |
| 54 | Abnormal glycosylation (HP:0012345) | 2.17894076 |
| 55 | Degeneration of anterior horn cells (HP:0002398) | 2.17633399 |
| 56 | Abnormality of the anterior horn cell (HP:0006802) | 2.17633399 |
| 57 | Colon cancer (HP:0003003) | 2.15269204 |
| 58 | Renal cortical cysts (HP:0000803) | 2.15052446 |
| 59 | B lymphocytopenia (HP:0010976) | 2.13358488 |
| 60 | Abnormality of the pons (HP:0007361) | 2.12756228 |
| 61 | Oral leukoplakia (HP:0002745) | 2.11963438 |
| 62 | Increased serum pyruvate (HP:0003542) | 2.09417994 |
| 63 | Type 2 muscle fiber atrophy (HP:0003554) | 2.09415170 |
| 64 | Respiratory failure (HP:0002878) | 2.05836268 |
| 65 | Increased intramyocellular lipid droplets (HP:0012240) | 2.05636817 |
| 66 | Exertional dyspnea (HP:0002875) | 2.05364475 |
| 67 | Thyroiditis (HP:0100646) | 2.05203854 |
| 68 | Attenuation of retinal blood vessels (HP:0007843) | 2.04931846 |
| 69 | Abnormality of serum amino acid levels (HP:0003112) | 2.04410211 |
| 70 | Pancytopenia (HP:0001876) | 2.03978110 |
| 71 | Hyperglycinuria (HP:0003108) | 2.02746240 |
| 72 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.01773468 |
| 73 | Dicarboxylic aciduria (HP:0003215) | 2.01773468 |
| 74 | Hypoplasia of the pons (HP:0012110) | 1.99023847 |
| 75 | Palpitations (HP:0001962) | 1.97823350 |
| 76 | Abnormality of the prostate (HP:0008775) | 1.92516208 |
| 77 | Neoplasm of the adrenal gland (HP:0100631) | 1.91359149 |
| 78 | Abnormality of glycine metabolism (HP:0010895) | 1.90529278 |
| 79 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.90529278 |
| 80 | Meckel diverticulum (HP:0002245) | 1.89824352 |
| 81 | Abnormality of the renal cortex (HP:0011035) | 1.87055314 |
| 82 | Progressive inability to walk (HP:0002505) | 1.85944215 |
| 83 | Pendular nystagmus (HP:0012043) | 1.85869673 |
| 84 | Hypomagnesemia (HP:0002917) | 1.84298779 |
| 85 | Generalized aminoaciduria (HP:0002909) | 1.84135036 |
| 86 | Decreased central vision (HP:0007663) | 1.83703891 |
| 87 | Megaloblastic anemia (HP:0001889) | 1.83607317 |
| 88 | Glycosuria (HP:0003076) | 1.83003745 |
| 89 | Abnormality of urine glucose concentration (HP:0011016) | 1.83003745 |
| 90 | Abnormality of the ileum (HP:0001549) | 1.82655539 |
| 91 | Constricted visual fields (HP:0001133) | 1.81882858 |
| 92 | Reduced antithrombin III activity (HP:0001976) | 1.80673373 |
| 93 | Exercise intolerance (HP:0003546) | 1.80392148 |
| 94 | Leukodystrophy (HP:0002415) | 1.80243572 |
| 95 | Abnormality of homocysteine metabolism (HP:0010919) | 1.79973410 |
| 96 | Homocystinuria (HP:0002156) | 1.79973410 |
| 97 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.79168492 |
| 98 | Increased IgM level (HP:0003496) | 1.78121003 |
| 99 | Type II lissencephaly (HP:0007260) | 1.77989244 |
| 100 | T lymphocytopenia (HP:0005403) | 1.77883005 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TSSK6 | 5.09018802 |
| 2 | MAP4K2 | 3.46079773 |
| 3 | EIF2AK3 | 3.38426877 |
| 4 | VRK2 | 2.65744040 |
| 5 | MST4 | 2.62879394 |
| 6 | ZAK | 2.45339317 |
| 7 | NUAK1 | 2.38348217 |
| 8 | TRIM28 | 2.33424707 |
| 9 | TXK | 2.16934296 |
| 10 | NEK1 | 2.16649993 |
| 11 | EIF2AK1 | 2.12177846 |
| 12 | SRPK1 | 2.10932061 |
| 13 | VRK1 | 1.98218916 |
| 14 | WNK3 | 1.97939779 |
| 15 | BCKDK | 1.97602201 |
| 16 | BUB1 | 1.92512184 |
| 17 | TLK1 | 1.90740373 |
| 18 | PLK3 | 1.75374204 |
| 19 | TAOK3 | 1.75289610 |
| 20 | FRK | 1.72351665 |
| 21 | ADRBK2 | 1.70064651 |
| 22 | MKNK1 | 1.69092631 |
| 23 | TAF1 | 1.67160801 |
| 24 | MKNK2 | 1.66945545 |
| 25 | BMPR1B | 1.62244732 |
| 26 | GRK1 | 1.54313980 |
| 27 | TIE1 | 1.49609619 |
| 28 | PLK4 | 1.43001193 |
| 29 | BCR | 1.39684281 |
| 30 | MAP3K12 | 1.32999801 |
| 31 | CSNK1G3 | 1.26737215 |
| 32 | CSNK1G2 | 1.20876494 |
| 33 | TEC | 1.16245069 |
| 34 | PASK | 1.14764129 |
| 35 | CSNK1G1 | 1.14569654 |
| 36 | ERBB3 | 1.11595277 |
| 37 | STK16 | 1.05326056 |
| 38 | KDR | 1.04645403 |
| 39 | WNK4 | 1.04295337 |
| 40 | CSNK1A1L | 1.01699940 |
| 41 | PBK | 0.99978839 |
| 42 | PLK2 | 0.99103746 |
| 43 | MAP3K4 | 0.98127887 |
| 44 | OXSR1 | 0.98086780 |
| 45 | INSRR | 0.95348576 |
| 46 | EIF2AK2 | 0.95117743 |
| 47 | PINK1 | 0.94177827 |
| 48 | ACVR1B | 0.90183825 |
| 49 | NME1 | 0.85644700 |
| 50 | CDC7 | 0.85292513 |
| 51 | WEE1 | 0.81806458 |
| 52 | RPS6KA4 | 0.75973200 |
| 53 | ITK | 0.75414462 |
| 54 | MAPKAPK5 | 0.71986426 |
| 55 | TTK | 0.71543654 |
| 56 | CDK19 | 0.71383729 |
| 57 | STK39 | 0.69718491 |
| 58 | MAP2K7 | 0.68919234 |
| 59 | RPS6KA5 | 0.68294939 |
| 60 | DAPK1 | 0.66436553 |
| 61 | DYRK2 | 0.62778383 |
| 62 | PLK1 | 0.62678126 |
| 63 | SIK3 | 0.61799753 |
| 64 | MAP4K1 | 0.59293649 |
| 65 | MAP2K6 | 0.59055757 |
| 66 | PIM2 | 0.58938074 |
| 67 | MAPK13 | 0.57771179 |
| 68 | ALK | 0.54356447 |
| 69 | PRKCE | 0.52361585 |
| 70 | IKBKB | 0.50604933 |
| 71 | TGFBR1 | 0.49913080 |
| 72 | ATR | 0.49889593 |
| 73 | PRKCQ | 0.48844646 |
| 74 | TNIK | 0.48384849 |
| 75 | PHKG1 | 0.47796387 |
| 76 | PHKG2 | 0.47796387 |
| 77 | BRSK2 | 0.47082607 |
| 78 | KIT | 0.43731449 |
| 79 | LIMK1 | 0.39756296 |
| 80 | FLT3 | 0.37954314 |
| 81 | CSNK2A1 | 0.37792600 |
| 82 | FES | 0.37550822 |
| 83 | CLK1 | 0.37444447 |
| 84 | CSNK2A2 | 0.36229964 |
| 85 | STK38L | 0.35276147 |
| 86 | IKBKE | 0.34248498 |
| 87 | SYK | 0.34179792 |
| 88 | ATM | 0.33270357 |
| 89 | CDK8 | 0.32610733 |
| 90 | MINK1 | 0.30925208 |
| 91 | ADRBK1 | 0.30411112 |
| 92 | CSNK1A1 | 0.30219188 |
| 93 | TESK1 | 0.30141114 |
| 94 | PDK2 | 0.29454758 |
| 95 | DAPK2 | 0.29280138 |
| 96 | AURKB | 0.29247791 |
| 97 | PRKCI | 0.27986781 |
| 98 | PRKCG | 0.27596875 |
| 99 | CAMK2A | 0.26312671 |
| 100 | LCK | 0.25874099 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.94223135 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.41247306 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.91058754 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.80359567 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.72709528 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.51307586 |
| 7 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.06907598 |
| 8 | RNA degradation_Homo sapiens_hsa03018 | 1.94827695 |
| 9 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.92928340 |
| 10 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.86222605 |
| 11 | Mismatch repair_Homo sapiens_hsa03430 | 1.85005645 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.83466355 |
| 13 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.82763415 |
| 14 | Basal transcription factors_Homo sapiens_hsa03022 | 1.82620462 |
| 15 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.75209283 |
| 16 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.73719420 |
| 17 | Homologous recombination_Homo sapiens_hsa03440 | 1.72834702 |
| 18 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.64287215 |
| 19 | RNA transport_Homo sapiens_hsa03013 | 1.64210536 |
| 20 | Asthma_Homo sapiens_hsa05310 | 1.62704691 |
| 21 | Spliceosome_Homo sapiens_hsa03040 | 1.61280063 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.59241242 |
| 23 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.58095023 |
| 24 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.55133829 |
| 25 | Alzheimers disease_Homo sapiens_hsa05010 | 1.50196070 |
| 26 | Allograft rejection_Homo sapiens_hsa05330 | 1.49773421 |
| 27 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.47399036 |
| 28 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.41605168 |
| 29 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.40699556 |
| 30 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.39903029 |
| 31 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.39357867 |
| 32 | DNA replication_Homo sapiens_hsa03030 | 1.35132517 |
| 33 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.28443372 |
| 34 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.25725919 |
| 35 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.24564845 |
| 36 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.21240739 |
| 37 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.20894863 |
| 38 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.20307471 |
| 39 | Phototransduction_Homo sapiens_hsa04744 | 1.20152702 |
| 40 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.18285580 |
| 41 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.17902430 |
| 42 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.15795946 |
| 43 | Purine metabolism_Homo sapiens_hsa00230 | 1.15580287 |
| 44 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.09201863 |
| 45 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.08560078 |
| 46 | Base excision repair_Homo sapiens_hsa03410 | 1.07721639 |
| 47 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.06095481 |
| 48 | Ribosome_Homo sapiens_hsa03010 | 1.04722571 |
| 49 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.03874775 |
| 50 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.00114246 |
| 51 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.99972144 |
| 52 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.99015820 |
| 53 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.97347997 |
| 54 | Peroxisome_Homo sapiens_hsa04146 | 0.97073762 |
| 55 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.95679060 |
| 56 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.95513926 |
| 57 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.87801821 |
| 58 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.83886239 |
| 59 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.83351436 |
| 60 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.79834523 |
| 61 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.77222932 |
| 62 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.74613041 |
| 63 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.71281601 |
| 64 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.70150257 |
| 65 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68742574 |
| 66 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.68741896 |
| 67 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.65991544 |
| 68 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.63606904 |
| 69 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.61719003 |
| 70 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.60757861 |
| 71 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.57793162 |
| 72 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.57577108 |
| 73 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.54157876 |
| 74 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.52550680 |
| 75 | Legionellosis_Homo sapiens_hsa05134 | 0.52410945 |
| 76 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.51359587 |
| 77 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.49743490 |
| 78 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.49041370 |
| 79 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.48294569 |
| 80 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.48143980 |
| 81 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.47833747 |
| 82 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.46703386 |
| 83 | Retinol metabolism_Homo sapiens_hsa00830 | 0.44226695 |
| 84 | Carbon metabolism_Homo sapiens_hsa01200 | 0.42759362 |
| 85 | Sulfur relay system_Homo sapiens_hsa04122 | 0.41903313 |
| 86 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.41876375 |
| 87 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.41065727 |
| 88 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.40835316 |
| 89 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.37600799 |
| 90 | Olfactory transduction_Homo sapiens_hsa04740 | 0.36065128 |
| 91 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.35937052 |
| 92 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.35690025 |
| 93 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.35522716 |
| 94 | Cell cycle_Homo sapiens_hsa04110 | 0.35231008 |
| 95 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.32194649 |
| 96 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.31104895 |
| 97 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.31069635 |
| 98 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.30516299 |
| 99 | Measles_Homo sapiens_hsa05162 | 0.28434588 |
| 100 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.27325684 |

