HSPA8P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)7.72671309
2DNA deamination (GO:0045006)5.92927847
3nucleotide transmembrane transport (GO:1901679)4.90412829
4DNA double-strand break processing (GO:0000729)4.71422115
5proteasome assembly (GO:0043248)4.69683516
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.61192808
7rRNA modification (GO:0000154)4.56484924
8protein-cofactor linkage (GO:0018065)4.46254158
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.45907670
10ATP synthesis coupled proton transport (GO:0015986)4.45907670
11chaperone-mediated protein transport (GO:0072321)4.38655892
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.38109737
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.38109737
14pseudouridine synthesis (GO:0001522)4.33857689
15water-soluble vitamin biosynthetic process (GO:0042364)4.33836148
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.31576844
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.22819312
18intracellular protein transmembrane import (GO:0044743)4.17377218
19rRNA methylation (GO:0031167)4.15684383
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.09725239
21protein import into peroxisome matrix (GO:0016558)4.08714242
22nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.05010200
23regulation of isotype switching to IgG isotypes (GO:0048302)3.98014909
24protein neddylation (GO:0045116)3.89713858
25transcription elongation from RNA polymerase III promoter (GO:0006385)3.78176226
26termination of RNA polymerase III transcription (GO:0006386)3.78176226
27spliceosomal snRNP assembly (GO:0000387)3.71184201
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.70998226
29NADH dehydrogenase complex assembly (GO:0010257)3.70998226
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70998226
31negative regulation of protein oligomerization (GO:0032460)3.69779630
32rRNA catabolic process (GO:0016075)3.67043553
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.61310058
34ribosome assembly (GO:0042255)3.55186081
35protein complex biogenesis (GO:0070271)3.52884898
36platelet dense granule organization (GO:0060155)3.51812194
37respiratory electron transport chain (GO:0022904)3.48324600
38regulation of cellular amino acid metabolic process (GO:0006521)3.47778653
39rRNA metabolic process (GO:0016072)3.46973472
40electron transport chain (GO:0022900)3.43512311
41rRNA processing (GO:0006364)3.43418948
42mitochondrial RNA metabolic process (GO:0000959)3.42796562
43mitochondrial respiratory chain complex assembly (GO:0033108)3.41024476
44GTP biosynthetic process (GO:0006183)3.40754920
45tRNA processing (GO:0008033)3.38018329
46chromatin remodeling at centromere (GO:0031055)3.35045741
47negative regulation of telomere maintenance (GO:0032205)3.29833087
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29100816
49regulation of response to tumor cell (GO:0002834)3.25910772
50positive regulation of response to tumor cell (GO:0002836)3.25910772
51positive regulation of immune response to tumor cell (GO:0002839)3.25910772
52regulation of immune response to tumor cell (GO:0002837)3.25910772
53cullin deneddylation (GO:0010388)3.25814591
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25153887
55DNA catabolic process, exonucleolytic (GO:0000738)3.22932370
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22391464
57negative regulation of ligase activity (GO:0051352)3.22391464
58RNA capping (GO:0036260)3.21440040
597-methylguanosine RNA capping (GO:0009452)3.21440040
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21310229
61intracellular protein transmembrane transport (GO:0065002)3.18858662
62transcription from mitochondrial promoter (GO:0006390)3.18851831
63CENP-A containing nucleosome assembly (GO:0034080)3.18543336
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18541889
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18541889
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18541889
67regulation of immunoglobulin secretion (GO:0051023)3.17678174
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15495361
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15495361
70behavioral response to nicotine (GO:0035095)3.11010480
71inner mitochondrial membrane organization (GO:0007007)3.09592049
72tRNA metabolic process (GO:0006399)3.08872108
73negative regulation of DNA-dependent DNA replication (GO:2000104)3.08138893
74cellular component biogenesis (GO:0044085)3.04258314
75folic acid-containing compound biosynthetic process (GO:0009396)3.04256482
76isotype switching (GO:0045190)3.04064874
77somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.04064874
78somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.04064874
79signal transduction involved in DNA integrity checkpoint (GO:0072401)3.03024752
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.03024752
81respiratory chain complex IV assembly (GO:0008535)3.01650493
82ncRNA metabolic process (GO:0034660)3.00800620
83protein targeting to peroxisome (GO:0006625)2.99958373
84establishment of protein localization to peroxisome (GO:0072663)2.99958373
85protein localization to peroxisome (GO:0072662)2.99958373
86regulation of chronic inflammatory response (GO:0002676)2.99501881
87signal transduction involved in cell cycle checkpoint (GO:0072395)2.98634344
88ribonucleoprotein complex biogenesis (GO:0022613)2.95642295
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95029853
90DNA damage response, detection of DNA damage (GO:0042769)2.93796030
91ncRNA processing (GO:0034470)2.93573707
92protein transmembrane transport (GO:0071806)2.92871823
93UTP biosynthetic process (GO:0006228)2.90028262
94IMP biosynthetic process (GO:0006188)2.90009189
95ribosome biogenesis (GO:0042254)2.89389111
96purine nucleoside triphosphate biosynthetic process (GO:0009145)2.88130982
97protein deneddylation (GO:0000338)2.87511478
98RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86987038
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85822119
100nucleobase biosynthetic process (GO:0046112)2.83846317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.69827856
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.13471598
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.58121942
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.96434561
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.34743844
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.08700955
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.08342479
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.74012374
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.72317770
10VDR_23849224_ChIP-Seq_CD4+_Human2.65060242
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47090067
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46804177
13VDR_22108803_ChIP-Seq_LS180_Human2.39631398
14ZNF274_21170338_ChIP-Seq_K562_Hela2.39533831
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39497249
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.38636305
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36830148
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.34833672
19FOXP3_21729870_ChIP-Seq_TREG_Human2.31901207
20ELK1_19687146_ChIP-ChIP_HELA_Human2.31261312
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21744305
22YY1_21170310_ChIP-Seq_MESCs_Mouse1.97993654
23E2F7_22180533_ChIP-Seq_HELA_Human1.95177780
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94489720
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.91375486
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90627901
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90587163
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86072112
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85219448
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84781842
31EWS_26573619_Chip-Seq_HEK293_Human1.80450607
32MYC_18940864_ChIP-ChIP_HL60_Human1.66146581
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64404657
34TTF2_22483619_ChIP-Seq_HELA_Human1.63453956
35DCP1A_22483619_ChIP-Seq_HELA_Human1.61569696
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61003720
37GABP_19822575_ChIP-Seq_HepG2_Human1.52976574
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45862037
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45357806
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42105315
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40335767
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37506028
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36975583
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36623512
45TP53_22573176_ChIP-Seq_HFKS_Human1.35931515
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35915241
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35514436
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34760738
49XRN2_22483619_ChIP-Seq_HELA_Human1.31127382
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25632791
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24549210
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.21047202
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.19983267
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19983267
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19731733
56IGF1R_20145208_ChIP-Seq_DFB_Human1.17574995
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16196326
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15566750
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14943307
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13616395
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13352103
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12013463
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11963325
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11456474
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09651813
66IRF1_19129219_ChIP-ChIP_H3396_Human1.07681821
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.07565764
68SOX2_19829295_ChIP-Seq_ESCs_Human1.06497191
69NANOG_19829295_ChIP-Seq_ESCs_Human1.06497191
70P300_19829295_ChIP-Seq_ESCs_Human1.06409370
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04530915
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02048564
73TAF15_26573619_Chip-Seq_HEK293_Human1.00684722
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00283362
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00263306
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97079489
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96916525
78RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96199558
79EZH2_27294783_Chip-Seq_NPCs_Mouse0.96168277
80FUS_26573619_Chip-Seq_HEK293_Human0.95141437
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92189585
82EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91747367
83NCOR_22424771_ChIP-Seq_293T_Human0.89776793
84KDM5A_27292631_Chip-Seq_BREAST_Human0.85049549
85AR_20517297_ChIP-Seq_VCAP_Human0.84553748
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83952613
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83900718
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.83294935
89FOXH1_21741376_ChIP-Seq_EPCs_Human0.81828537
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81503196
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80078866
92P300_18555785_Chip-Seq_ESCs_Mouse0.79961992
93NANOG_16153702_ChIP-ChIP_HESCs_Human0.79124162
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79052194
95HOXB7_26014856_ChIP-Seq_BT474_Human0.79011504
96BMI1_23680149_ChIP-Seq_NPCS_Mouse0.77733338
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.75902656
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.75667459
99RBPJ_21746931_ChIP-Seq_IB4_Human0.75331343
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.75062617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.68941488
2MP0006082_CNS_inflammation3.35223961
3MP0001348_abnormal_lacrimal_gland3.28220375
4MP0002102_abnormal_ear_morphology3.22730513
5MP0001873_stomach_inflammation3.03135383
6MP0002876_abnormal_thyroid_physiology2.85216758
7MP0008877_abnormal_DNA_methylation2.76872161
8MP0003693_abnormal_embryo_hatching2.29055640
9MP0003718_maternal_effect2.28560769
10MP0006072_abnormal_retinal_apoptosis2.25664544
11MP0005360_urolithiasis2.21558470
12MP0008058_abnormal_DNA_repair2.16014738
13MP0002837_dystrophic_cardiac_calcinosis2.00365287
14MP0005671_abnormal_response_to1.98056334
15MP0004142_abnormal_muscle_tone1.96483535
16MP0006292_abnormal_olfactory_placode1.93462145
17MP0001188_hyperpigmentation1.93421517
18MP0008875_abnormal_xenobiotic_pharmacok1.92417302
19MP0008872_abnormal_physiological_respon1.76917142
20MP0003786_premature_aging1.75971318
21MP0000685_abnormal_immune_system1.75524122
22MP0002277_abnormal_respiratory_mucosa1.73380930
23MP0001984_abnormal_olfaction1.72374198
24MP0005645_abnormal_hypothalamus_physiol1.67063849
25MP0004957_abnormal_blastocyst_morpholog1.65514722
26MP0002736_abnormal_nociception_after1.63635079
27MP0003806_abnormal_nucleotide_metabolis1.63598718
28MP0002138_abnormal_hepatobiliary_system1.61272764
29MP0004147_increased_porphyrin_level1.59345363
30MP0009333_abnormal_splenocyte_physiolog1.51334559
31MP0004885_abnormal_endolymph1.47886916
32MP0010094_abnormal_chromosome_stability1.46409912
33MP0001919_abnormal_reproductive_system1.45139011
34MP0005084_abnormal_gallbladder_morpholo1.44610129
35MP0003195_calcinosis1.44393611
36MP0001968_abnormal_touch/_nociception1.40757985
37MP0001346_abnormal_lacrimal_gland1.37139997
38MP0009046_muscle_twitch1.34143401
39MP0003011_delayed_dark_adaptation1.29683887
40MP0005551_abnormal_eye_electrophysiolog1.29025792
41MP0003186_abnormal_redox_activity1.28499541
42MP0001835_abnormal_antigen_presentation1.24838837
43MP0002272_abnormal_nervous_system1.22890172
44MP0005389_reproductive_system_phenotype1.21671188
45MP0009785_altered_susceptibility_to1.21168686
46MP0001790_abnormal_immune_system1.20302713
47MP0005387_immune_system_phenotype1.20302713
48MP0005253_abnormal_eye_physiology1.18689470
49MP0001293_anophthalmia1.18681657
50MP0005310_abnormal_salivary_gland1.17446691
51MP0004742_abnormal_vestibular_system1.17319843
52MP0002163_abnormal_gland_morphology1.14563858
53MP0003646_muscle_fatigue1.11734315
54MP0009697_abnormal_copulation1.08917535
55MP0005379_endocrine/exocrine_gland_phen1.07536001
56MP0001501_abnormal_sleep_pattern1.04380180
57MP0006035_abnormal_mitochondrial_morpho1.03357615
58MP0004145_abnormal_muscle_electrophysio1.02829969
59MP0006276_abnormal_autonomic_nervous1.00625831
60MP0004043_abnormal_pH_regulation1.00303870
61MP0005167_abnormal_blood-brain_barrier0.99802040
62MP0006036_abnormal_mitochondrial_physio0.96853674
63MP0002938_white_spotting0.96565900
64MP0005636_abnormal_mineral_homeostasis0.96080324
65MP0002132_abnormal_respiratory_system0.95774635
66MP0001529_abnormal_vocalization0.94775016
67MP0009745_abnormal_behavioral_response0.91522333
68MP0008995_early_reproductive_senescence0.90568480
69MP0009765_abnormal_xenobiotic_induced0.89101480
70MP0001800_abnormal_humoral_immune0.87760344
71MP0000631_abnormal_neuroendocrine_gland0.85565207
72MP0001119_abnormal_female_reproductive0.82334920
73MP0002160_abnormal_reproductive_system0.79758090
74MP0002735_abnormal_chemical_nociception0.79548575
75MP0003763_abnormal_thymus_physiology0.77424746
76MP0001764_abnormal_homeostasis0.76295911
77MP0001485_abnormal_pinna_reflex0.76254062
78MP0003567_abnormal_fetal_cardiomyocyte0.76144335
79MP0008007_abnormal_cellular_replicative0.75067090
80MP0002822_catalepsy0.74726706
81MP0000372_irregular_coat_pigmentation0.74470352
82MP0004019_abnormal_vitamin_homeostasis0.72873629
83MP0001986_abnormal_taste_sensitivity0.71757633
84MP0003111_abnormal_nucleus_morphology0.71710973
85MP0005085_abnormal_gallbladder_physiolo0.71531961
86MP0001905_abnormal_dopamine_level0.71179481
87MP0009379_abnormal_foot_pigmentation0.70958593
88MP0002693_abnormal_pancreas_physiology0.70490912
89MP0002210_abnormal_sex_determination0.69869576
90MP0002148_abnormal_hypersensitivity_rea0.68812401
91MP0002405_respiratory_system_inflammati0.68707627
92MP0001663_abnormal_digestive_system0.68281950
93MP0000653_abnormal_sex_gland0.66654782
94MP0005646_abnormal_pituitary_gland0.66303846
95MP0003936_abnormal_reproductive_system0.64676777
96MP0001440_abnormal_grooming_behavior0.64197073
97MP0001486_abnormal_startle_reflex0.64060455
98MP0003787_abnormal_imprinting0.63619186
99MP0008873_increased_physiological_sensi0.62627908
100MP0003866_abnormal_defecation0.61896196

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.14129768
2Increased CSF lactate (HP:0002490)3.92774565
3Methylmalonic acidemia (HP:0002912)3.86115727
4Acute encephalopathy (HP:0006846)3.82121624
5Mitochondrial inheritance (HP:0001427)3.76032278
6Abnormal mitochondria in muscle tissue (HP:0008316)3.60671901
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.53240687
8Abnormality of alanine metabolism (HP:0010916)3.53240687
9Hyperalaninemia (HP:0003348)3.53240687
10Stomatitis (HP:0010280)3.50813636
11Increased hepatocellular lipid droplets (HP:0006565)3.49320985
12Progressive macrocephaly (HP:0004481)3.40383697
13Methylmalonic aciduria (HP:0012120)3.38007918
14Lipid accumulation in hepatocytes (HP:0006561)3.37133619
15Hepatocellular necrosis (HP:0001404)3.37020585
16Increased serum lactate (HP:0002151)3.17367442
17Hepatic necrosis (HP:0002605)3.12718156
18Brushfield spots (HP:0001088)3.12484329
19Abnormality of the labia minora (HP:0012880)3.06904736
20Abnormality of the pons (HP:0007361)3.05933281
21Hypoplasia of the pons (HP:0012110)3.04335518
22Cerebral edema (HP:0002181)2.87525129
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80357081
24Lactic acidosis (HP:0003128)2.73153222
25Pendular nystagmus (HP:0012043)2.70658084
26Increased IgM level (HP:0003496)2.64383018
273-Methylglutaconic aciduria (HP:0003535)2.63413520
28IgG deficiency (HP:0004315)2.61963802
29Aplastic anemia (HP:0001915)2.61484539
30Pancytopenia (HP:0001876)2.55844863
31Renal Fanconi syndrome (HP:0001994)2.55512858
32Lethargy (HP:0001254)2.53350423
33Abnormality of methionine metabolism (HP:0010901)2.52114905
34Oral leukoplakia (HP:0002745)2.50134025
35Hyperglycinemia (HP:0002154)2.48271110
36Aplasia/Hypoplasia of the spleen (HP:0010451)2.46608350
37Abnormality of the vitamin B12 metabolism (HP:0004341)2.44932827
38Asplenia (HP:0001746)2.44384789
39Type II lissencephaly (HP:0007260)2.40264580
40Abnormality of serum amino acid levels (HP:0003112)2.38986655
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.38580669
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37824463
43Abnormality of vitamin B metabolism (HP:0004340)2.35751633
44Hypomagnesemia (HP:0002917)2.33260956
45Abnormality of midbrain morphology (HP:0002418)2.32902783
46Molar tooth sign on MRI (HP:0002419)2.32902783
47Colon cancer (HP:0003003)2.32804209
48Female pseudohermaphroditism (HP:0010458)2.29789837
49Optic disc pallor (HP:0000543)2.28473683
50Megaloblastic anemia (HP:0001889)2.26950357
51Abnormality of homocysteine metabolism (HP:0010919)2.22448134
52Homocystinuria (HP:0002156)2.22448134
53Congenital, generalized hypertrichosis (HP:0004540)2.22245063
54Chronic mucocutaneous candidiasis (HP:0002728)2.16741613
55Recurrent cutaneous fungal infections (HP:0011370)2.16741613
56Increased intramyocellular lipid droplets (HP:0012240)2.16656171
57Glycosuria (HP:0003076)2.15551184
58Abnormality of urine glucose concentration (HP:0011016)2.15551184
59Pancreatic cysts (HP:0001737)2.13928507
60Abnormality of magnesium homeostasis (HP:0004921)2.12869335
61Reticulocytopenia (HP:0001896)2.10493068
62Abnormality of glycine metabolism (HP:0010895)2.08350945
63Abnormality of serine family amino acid metabolism (HP:0010894)2.08350945
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06427270
65Respiratory failure (HP:0002878)2.05949701
66Hyperglycinuria (HP:0003108)2.05509459
67Abnormality of B cell number (HP:0010975)2.05309240
68Abnormality of the anterior horn cell (HP:0006802)2.04945827
69Degeneration of anterior horn cells (HP:0002398)2.04945827
70True hermaphroditism (HP:0010459)2.03840569
71Exercise intolerance (HP:0003546)2.01412575
72Nephronophthisis (HP:0000090)2.00260731
73Abolished electroretinogram (ERG) (HP:0000550)1.97516657
74Horseshoe kidney (HP:0000085)1.95599556
75Meckel diverticulum (HP:0002245)1.94048430
76Constricted visual fields (HP:0001133)1.93854490
77Epiphyseal stippling (HP:0010655)1.91949582
78Exertional dyspnea (HP:0002875)1.91186959
79Abnormal drinking behavior (HP:0030082)1.91077327
80Polydipsia (HP:0001959)1.91077327
81Primary adrenal insufficiency (HP:0008207)1.88978582
82Leukodystrophy (HP:0002415)1.88029197
83Abnormality of the ileum (HP:0001549)1.86929120
84Hyperphosphaturia (HP:0003109)1.85169451
85Generalized aminoaciduria (HP:0002909)1.83134234
86Congenital stationary night blindness (HP:0007642)1.83106169
87Increased serum pyruvate (HP:0003542)1.82070392
88Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81498581
89Dicarboxylic aciduria (HP:0003215)1.81498581
90Increased muscle lipid content (HP:0009058)1.81150594
91Neutropenia (HP:0001875)1.78107660
92Aplasia/Hypoplasia of the uvula (HP:0010293)1.76366645
93Medial flaring of the eyebrow (HP:0010747)1.75962168
94Pancreatic fibrosis (HP:0100732)1.74382566
95Large for gestational age (HP:0001520)1.74102439
96Aplasia/hypoplasia of the uterus (HP:0008684)1.73569493
97Abnormality of sulfur amino acid metabolism (HP:0004339)1.69892398
98Abnormality of chromosome stability (HP:0003220)1.69808094
99CNS demyelination (HP:0007305)1.69209201
100Ketoacidosis (HP:0001993)1.69162513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.91638605
2PASK3.37463171
3VRK22.80555938
4STK162.74248830
5MST42.53184936
6BUB12.34571662
7ZAK2.29028567
8EIF2AK12.26842905
9NEK12.18679709
10TXK2.18576399
11SRPK12.11301360
12NUAK12.08233239
13EIF2AK32.05861420
14ADRBK22.05652231
15TRIM282.01776793
16WNK42.00163398
17VRK11.84089554
18PLK31.79560521
19GRK11.77956153
20TLK11.77040944
21PBK1.72850592
22STK391.72183627
23ACVR1B1.63013552
24TAF11.53139281
25MKNK21.53015458
26OXSR11.38199975
27BMPR1B1.35538174
28WNK31.34771711
29TAOK31.30767749
30NME11.29689664
31CDC71.29610704
32DYRK21.18441083
33MAP3K121.15297731
34MAP4K21.15129016
35ITK1.13451027
36BCKDK1.10646599
37MKNK11.06587707
38BCR0.99501789
39TNIK0.98098670
40CSNK1G20.97259136
41PLK40.94362128
42PLK10.93601049
43EIF2AK20.92361650
44CSNK1G30.91154657
45MAPKAPK50.90597150
46TTK0.89772450
47MAP2K60.88087822
48WEE10.83817813
49ALK0.83526370
50PLK20.82429969
51CSNK1G10.81241819
52TIE10.80341680
53CSNK1A1L0.76634028
54FRK0.74467948
55TEC0.73612051
56INSRR0.67875773
57FGR0.65718436
58IKBKB0.65271881
59PINK10.64189727
60PHKG10.63944398
61PHKG20.63944398
62MAP3K140.62924915
63PDK20.60347172
64ATR0.59170753
65PRKCG0.58753893
66CASK0.54676502
67PRKCQ0.53900322
68CCNB10.53441824
69MAP4K10.53108849
70RPS6KA50.49036448
71CSNK2A20.48121674
72STK38L0.46434070
73TGFBR10.46429167
74EPHB20.45079139
75CSNK2A10.45075091
76PAK30.44706294
77MAP3K110.42647969
78AURKA0.41468712
79NME20.40505907
80ATM0.39038409
81CAMKK10.38550357
82CSNK1E0.37926093
83CSNK1A10.37423312
84MAP2K70.37339363
85CHEK20.36507719
86AURKB0.36037611
87SIK30.35391275
88PNCK0.34084392
89FGFR10.33341859
90PIM20.32984861
91ADRBK10.32921057
92MAP3K40.32666723
93MAPK130.30469114
94PRKCE0.30350163
95MINK10.29540444
96PRKACA0.28007918
97CAMK2A0.27821383
98PRKCA0.27248272
99PRKCI0.25432049
100IKBKE0.25302193

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.36034926
2Oxidative phosphorylation_Homo sapiens_hsa001903.50960585
3Protein export_Homo sapiens_hsa030603.08256849
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.96765398
5Parkinsons disease_Homo sapiens_hsa050122.92462628
6RNA polymerase_Homo sapiens_hsa030202.84672037
7Ribosome_Homo sapiens_hsa030102.17416100
8RNA degradation_Homo sapiens_hsa030182.13428399
9One carbon pool by folate_Homo sapiens_hsa006702.07265207
10Huntingtons disease_Homo sapiens_hsa050162.00532207
11Mismatch repair_Homo sapiens_hsa034301.88344794
12Alzheimers disease_Homo sapiens_hsa050101.88098478
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71325311
14Non-homologous end-joining_Homo sapiens_hsa034501.69088508
15Homologous recombination_Homo sapiens_hsa034401.67944003
16Propanoate metabolism_Homo sapiens_hsa006401.65265729
17Basal transcription factors_Homo sapiens_hsa030221.64643336
18RNA transport_Homo sapiens_hsa030131.63767483
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58653350
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57564096
21Spliceosome_Homo sapiens_hsa030401.53705221
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52985663
23DNA replication_Homo sapiens_hsa030301.48164747
24Sulfur metabolism_Homo sapiens_hsa009201.47854474
25Pyrimidine metabolism_Homo sapiens_hsa002401.43048321
26Allograft rejection_Homo sapiens_hsa053301.40589149
27Asthma_Homo sapiens_hsa053101.38198436
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34487312
29Primary immunodeficiency_Homo sapiens_hsa053401.33568234
30Fanconi anemia pathway_Homo sapiens_hsa034601.33064188
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30948761
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30345299
33Autoimmune thyroid disease_Homo sapiens_hsa053201.30249667
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29731527
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.28363346
36Caffeine metabolism_Homo sapiens_hsa002321.27262953
37Vitamin digestion and absorption_Homo sapiens_hsa049771.26837728
38Cardiac muscle contraction_Homo sapiens_hsa042601.26064706
39Type I diabetes mellitus_Homo sapiens_hsa049401.23074741
40Vitamin B6 metabolism_Homo sapiens_hsa007501.19028890
41Linoleic acid metabolism_Homo sapiens_hsa005911.17795235
42Nucleotide excision repair_Homo sapiens_hsa034201.17772116
43Peroxisome_Homo sapiens_hsa041461.14599163
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14457102
45Purine metabolism_Homo sapiens_hsa002301.13418430
46Sulfur relay system_Homo sapiens_hsa041221.12343843
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.11056001
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08621870
49Phototransduction_Homo sapiens_hsa047441.02323009
50Base excision repair_Homo sapiens_hsa034101.02293940
51Collecting duct acid secretion_Homo sapiens_hsa049660.97699695
52Selenocompound metabolism_Homo sapiens_hsa004500.94545169
53Tryptophan metabolism_Homo sapiens_hsa003800.92567877
54Pyruvate metabolism_Homo sapiens_hsa006200.92358149
55Butanoate metabolism_Homo sapiens_hsa006500.88027443
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85549800
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.84806070
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84804323
59Steroid biosynthesis_Homo sapiens_hsa001000.82867507
60Graft-versus-host disease_Homo sapiens_hsa053320.80075349
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76417235
62Fat digestion and absorption_Homo sapiens_hsa049750.73582824
63Metabolic pathways_Homo sapiens_hsa011000.72605082
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71694814
65Retinol metabolism_Homo sapiens_hsa008300.71303230
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71197783
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70964928
68Fatty acid elongation_Homo sapiens_hsa000620.70914709
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68665692
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67307972
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.66503804
72Nitrogen metabolism_Homo sapiens_hsa009100.66028917
73Regulation of autophagy_Homo sapiens_hsa041400.63221561
74Mineral absorption_Homo sapiens_hsa049780.62047001
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58158714
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55985872
77Glutathione metabolism_Homo sapiens_hsa004800.54597985
78Chemical carcinogenesis_Homo sapiens_hsa052040.54185579
79Arachidonic acid metabolism_Homo sapiens_hsa005900.53228725
80Nicotine addiction_Homo sapiens_hsa050330.52694323
81Antigen processing and presentation_Homo sapiens_hsa046120.51037075
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50408742
83Ether lipid metabolism_Homo sapiens_hsa005650.50406038
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47117476
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46315336
86Rheumatoid arthritis_Homo sapiens_hsa053230.46057396
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45219759
88Epstein-Barr virus infection_Homo sapiens_hsa051690.44943843
89beta-Alanine metabolism_Homo sapiens_hsa004100.43774796
90Folate biosynthesis_Homo sapiens_hsa007900.42998122
91Arginine and proline metabolism_Homo sapiens_hsa003300.40270656
92Carbon metabolism_Homo sapiens_hsa012000.38891494
93Olfactory transduction_Homo sapiens_hsa047400.32125625
94Systemic lupus erythematosus_Homo sapiens_hsa053220.31441140
95Glycerolipid metabolism_Homo sapiens_hsa005610.30362901
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.29660876
97Fatty acid degradation_Homo sapiens_hsa000710.29562368
98Legionellosis_Homo sapiens_hsa051340.26997132
99Morphine addiction_Homo sapiens_hsa050320.26576271
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.26413209

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