ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.32986620
2	cytidine deamination (GO:0009972)	5.01571426
3	cytidine metabolic process (GO:0046087)	5.01571426
4	cytidine catabolic process (GO:0006216)	5.01571426
5	rRNA methylation (GO:0031167)	4.85889389
6	rRNA modification (GO:0000154)	4.84539943
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.50917022
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.48333584
9	proteasome assembly (GO:0043248)	4.30685216
10	folic acid-containing compound biosynthetic process (GO:0009396)	3.92643357
11	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.68099780
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.68099780
13	pseudouridine synthesis (GO:0001522)	3.64350892
14	protein complex biogenesis (GO:0070271)	3.56167899
15	protein-cofactor linkage (GO:0018065)	3.52942515
16	negative regulation by host of viral transcription (GO:0043922)	3.50109346
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.46789832
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.46789832
19	NADH dehydrogenase complex assembly (GO:0010257)	3.46789832
20	pteridine-containing compound biosynthetic process (GO:0042559)	3.39499766
21	indole-containing compound catabolic process (GO:0042436)	3.37965149
22	indolalkylamine catabolic process (GO:0046218)	3.37965149
23	tryptophan catabolic process (GO:0006569)	3.37965149
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.37494042
25	mitochondrial RNA metabolic process (GO:0000959)	3.35069568
26	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.33500101
27	tRNA processing (GO:0008033)	3.28986806
28	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.23935617
29	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.23935617
30	isotype switching (GO:0045190)	3.23935617
31	ribosome assembly (GO:0042255)	3.22515090
32	piRNA metabolic process (GO:0034587)	3.17537662
33	tRNA modification (GO:0006400)	3.15087320
34	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.15023311
35	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.14276985
36	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.13790046
37	ribosome biogenesis (GO:0042254)	3.10517998
38	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.10224716
39	termination of RNA polymerase III transcription (GO:0006386)	3.10224716
40	chaperone-mediated protein transport (GO:0072321)	3.09655403
41	tryptophan metabolic process (GO:0006568)	3.08980998
42	sperm motility (GO:0030317)	3.08825858
43	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.07025637
44	ATP synthesis coupled proton transport (GO:0015986)	3.07025637
45	protein targeting to mitochondrion (GO:0006626)	3.04899920
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.04003148
47	water-soluble vitamin biosynthetic process (GO:0042364)	3.03844534
48	peptidyl-histidine modification (GO:0018202)	3.03751457
49	kynurenine metabolic process (GO:0070189)	3.03022024
50	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.95416188
51	tRNA metabolic process (GO:0006399)	2.95402874
52	regulation of cellular amino acid metabolic process (GO:0006521)	2.95384800
53	DNA damage response, detection of DNA damage (GO:0042769)	2.93245664
54	protein localization to mitochondrion (GO:0070585)	2.86991514
55	protein polyglutamylation (GO:0018095)	2.86214613
56	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.84159688
57	establishment of protein localization to mitochondrion (GO:0072655)	2.83417396
58	rRNA processing (GO:0006364)	2.82489358
59	positive regulation of defense response to virus by host (GO:0002230)	2.80497845
60	regulation of mitochondrial translation (GO:0070129)	2.78019427
61	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.74902717
62	regulation of mitotic spindle checkpoint (GO:1903504)	2.74902717
63	respiratory chain complex IV assembly (GO:0008535)	2.74575187
64	histone mRNA metabolic process (GO:0008334)	2.74267382
65	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.73760563
66	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.73655304
67	negative regulation of ligase activity (GO:0051352)	2.73655304
68	rRNA metabolic process (GO:0016072)	2.73572310
69	indolalkylamine metabolic process (GO:0006586)	2.73218673
70	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.72028085
71	regulation of centriole replication (GO:0046599)	2.69439070
72	RNA modification (GO:0009451)	2.66865438
73	L-fucose catabolic process (GO:0042355)	2.66839058
74	fucose catabolic process (GO:0019317)	2.66839058
75	L-fucose metabolic process (GO:0042354)	2.66839058
76	tRNA methylation (GO:0030488)	2.66825454
77	ncRNA processing (GO:0034470)	2.66433610
78	male meiosis I (GO:0007141)	2.66085572
79	regulation of meiosis I (GO:0060631)	2.64959954
80	mannosylation (GO:0097502)	2.64818391
81	regulation of chronic inflammatory response (GO:0002676)	2.64582841
82	DNA double-strand break processing (GO:0000729)	2.63827874
83	positive regulation of T cell chemotaxis (GO:0010820)	2.63701237
84	regulation of T cell chemotaxis (GO:0010819)	2.63701237
85	cellular response to interleukin-15 (GO:0071350)	2.63430680
86	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.62876171
87	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.62876171
88	iron-sulfur cluster assembly (GO:0016226)	2.61999093
89	metallo-sulfur cluster assembly (GO:0031163)	2.61999093
90	negative regulation of T cell differentiation in thymus (GO:0033085)	2.61463701
91	ncRNA metabolic process (GO:0034660)	2.60146832
92	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.59626682
93	preassembly of GPI anchor in ER membrane (GO:0016254)	2.58564002
94	response to pheromone (GO:0019236)	2.58212223
95	regulation of isotype switching to IgG isotypes (GO:0048302)	2.58007752
96	adenosine metabolic process (GO:0046085)	2.57452910
97	cytochrome complex assembly (GO:0017004)	2.57046897
98	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.57019449
99	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.56138446
100	DNA methylation involved in gamete generation (GO:0043046)	2.55724087

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.97565373
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.53287769
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.23969391
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.55804831
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.55651952
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.43527081
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.24246834
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.10368879
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.94773963
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.81443741
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.78264134
12	FOXP3_21729870_ChIP-Seq_TREG_Human	2.57256448
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.50241195
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.48463804
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.33174580
16	E2F7_22180533_ChIP-Seq_HELA_Human	2.27713850
17	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.27220517
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.23440014
19	VDR_22108803_ChIP-Seq_LS180_Human	2.20475977
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.15542057
21	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.14687412
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.13754161
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.13582334
24	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.10213933
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.99438142
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.87732283
27	GABP_19822575_ChIP-Seq_HepG2_Human	1.86077397
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.85249335
29	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.83304673
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83017307
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.82895413
32	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.77286080
33	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.72513524
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.70962180
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.65259526
36	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.62998811
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55253569
38	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.54432948
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.53422730
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51923735
41	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.48129655
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.47879686
43	TTF2_22483619_ChIP-Seq_HELA_Human	1.45880962
44	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.45554071
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.37746473
46	EWS_26573619_Chip-Seq_HEK293_Human	1.33730179
47	XRN2_22483619_ChIP-Seq_HELA_Human	1.33090747
48	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.32639352
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.30635770
50	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.30057467
51	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.27961790
52	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.25469402
53	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.24240804
54	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.23886871
55	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.20883600
56	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.18414270
57	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.13582562
58	GATA3_26560356_Chip-Seq_TH2_Human	1.13209569
59	FUS_26573619_Chip-Seq_HEK293_Human	1.13167924
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11910646
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11910646
62	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.10495690
63	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.08375880
64	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.08042132
65	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.07250966
66	NCOR_22424771_ChIP-Seq_293T_Human	1.06600136
67	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.05966708
68	KDM5A_27292631_Chip-Seq_BREAST_Human	1.05754991
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.04918874
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04226473
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02971108
72	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.01383533
73	ERG_20517297_ChIP-Seq_VCAP_Human	1.01261713
74	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.99574190
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.96935609
76	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.95782137
77	MYC_19829295_ChIP-Seq_ESCs_Human	0.95566765
78	MYB_26560356_Chip-Seq_TH2_Human	0.93827244
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93810682
80	RBPJ_21746931_ChIP-Seq_IB4_Human	0.92359403
81	IGF1R_20145208_ChIP-Seq_DFB_Human	0.92249104
82	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.91449109
83	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.90729463
84	TAF2_19829295_ChIP-Seq_ESCs_Human	0.90588644
85	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.90370312
86	ER_23166858_ChIP-Seq_MCF-7_Human	0.88894465
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.88770018
88	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.88148252
89	CIITA_25753668_ChIP-Seq_RAJI_Human	0.87808898
90	AR_20517297_ChIP-Seq_VCAP_Human	0.87726830
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.87446408
92	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.87285575
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.86462001
94	CBP_20019798_ChIP-Seq_JUKART_Human	0.86462001
95	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.85314852
96	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85054752
97	ERA_21632823_ChIP-Seq_H3396_Human	0.84690266
98	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.84607488
99	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.83545550
100	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.82174763

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.21350758
2	MP0005377_hearing/vestibular/ear_phenot	3.18316587
3	MP0003878_abnormal_ear_physiology	3.18316587
4	MP0005360_urolithiasis	2.79145714
5	MP0003693_abnormal_embryo_hatching	2.75012734
6	MP0005671_abnormal_response_to	2.68964877
7	MP0003786_premature_aging	2.68066677
8	MP0005410_abnormal_fertilization	2.36180660
9	MP0008058_abnormal_DNA_repair	2.35303853
10	MP0004147_increased_porphyrin_level	2.14727994
11	MP0005084_abnormal_gallbladder_morpholo	2.13058579
12	MP0008877_abnormal_DNA_methylation	2.07348375
13	MP0006035_abnormal_mitochondrial_morpho	2.01319830
14	MP0008007_abnormal_cellular_replicative	1.91965727
15	MP0003806_abnormal_nucleotide_metabolis	1.91407108
16	MP0009333_abnormal_splenocyte_physiolog	1.85649921
17	MP0006072_abnormal_retinal_apoptosis	1.83981586
18	MP0001986_abnormal_taste_sensitivity	1.83430493
19	MP0008872_abnormal_physiological_respon	1.80638220
20	MP0010094_abnormal_chromosome_stability	1.80024580
21	MP0005379_endocrine/exocrine_gland_phen	1.76651280
22	MP0006036_abnormal_mitochondrial_physio	1.76601502
23	MP0005645_abnormal_hypothalamus_physiol	1.72712580
24	MP0002163_abnormal_gland_morphology	1.72222499
25	MP0004957_abnormal_blastocyst_morpholog	1.68920106
26	MP0001835_abnormal_antigen_presentation	1.63875390
27	MP0003111_abnormal_nucleus_morphology	1.60451709
28	MP0003718_maternal_effect	1.59373508
29	MP0005551_abnormal_eye_electrophysiolog	1.58515639
30	MP0003763_abnormal_thymus_physiology	1.57597566
31	MP0005646_abnormal_pituitary_gland	1.55137660
32	MP0001984_abnormal_olfaction	1.50796859
33	MP0001501_abnormal_sleep_pattern	1.38738273
34	MP0006276_abnormal_autonomic_nervous	1.36523407
35	MP0008875_abnormal_xenobiotic_pharmacok	1.35178225
36	MP0002837_dystrophic_cardiac_calcinosis	1.34147047
37	MP0004782_abnormal_surfactant_physiolog	1.34076348
38	MP0001929_abnormal_gametogenesis	1.31565274
39	MP0005332_abnormal_amino_acid	1.31324595
40	MP0004885_abnormal_endolymph	1.29726959
41	MP0001485_abnormal_pinna_reflex	1.22794555
42	MP0003646_muscle_fatigue	1.22721533
43	MP0002876_abnormal_thyroid_physiology	1.22492917
44	MP0005253_abnormal_eye_physiology	1.22377483
45	MP0009697_abnormal_copulation	1.20951869
46	MP0004043_abnormal_pH_regulation	1.20863095
47	MP0001188_hyperpigmentation	1.20799890
48	MP0000685_abnormal_immune_system	1.20627189
49	MP0003252_abnormal_bile_duct	1.20448686
50	MP0003698_abnormal_male_reproductive	1.20122781
51	MP0002210_abnormal_sex_determination	1.15847043
52	MP0004742_abnormal_vestibular_system	1.15712942
53	MP0001853_heart_inflammation	1.13965714
54	MP0002405_respiratory_system_inflammati	1.10320616
55	MP0000569_abnormal_digit_pigmentation	1.08998185
56	MP0001790_abnormal_immune_system	1.05860692
57	MP0005387_immune_system_phenotype	1.05860692
58	MP0002736_abnormal_nociception_after	1.05509210
59	MP0002148_abnormal_hypersensitivity_rea	1.05210763
60	MP0002138_abnormal_hepatobiliary_system	1.02780292
61	MP0003787_abnormal_imprinting	0.99683058
62	MP0001919_abnormal_reproductive_system	0.98442403
63	MP0002277_abnormal_respiratory_mucosa	0.97053505
64	MP0003077_abnormal_cell_cycle	0.96830429
65	MP0001502_abnormal_circadian_rhythm	0.96256350
66	MP0005310_abnormal_salivary_gland	0.95396108
67	MP0002254_reproductive_system_inflammat	0.95230467
68	MP0009785_altered_susceptibility_to	0.95185010
69	MP0005000_abnormal_immune_tolerance	0.94367007
70	MP0005423_abnormal_somatic_nervous	0.91182621
71	MP0002693_abnormal_pancreas_physiology	0.88835182
72	MP0005389_reproductive_system_phenotype	0.88233308
73	MP0000653_abnormal_sex_gland	0.87995493
74	MP0001905_abnormal_dopamine_level	0.87827396
75	MP0001881_abnormal_mammary_gland	0.87176320
76	MP0002723_abnormal_immune_serum	0.87127301
77	MP0003195_calcinosis	0.86662178
78	MP0000703_abnormal_thymus_morphology	0.85558762
79	MP0003866_abnormal_defecation	0.84584649
80	MP0001800_abnormal_humoral_immune	0.84293334
81	MP0002160_abnormal_reproductive_system	0.83905863
82	MP0001968_abnormal_touch/_nociception	0.83798435
83	MP0009765_abnormal_xenobiotic_induced	0.83699487
84	MP0001145_abnormal_male_reproductive	0.83215292
85	MP0002006_tumorigenesis	0.81325159
86	MP0003186_abnormal_redox_activity	0.81245017
87	MP0009745_abnormal_behavioral_response	0.81126983
88	MP0010307_abnormal_tumor_latency	0.80604162
89	MP0000689_abnormal_spleen_morphology	0.80102996
90	MP0001873_stomach_inflammation	0.80098080
91	MP0001661_extended_life_span	0.78939096
92	MP0000427_abnormal_hair_cycle	0.78461071
93	MP0000538_abnormal_urinary_bladder	0.78237722
94	MP0001764_abnormal_homeostasis	0.77725859
95	MP0005636_abnormal_mineral_homeostasis	0.77559949
96	MP0002928_abnormal_bile_duct	0.76750972
97	MP0002272_abnormal_nervous_system	0.76271849
98	MP0000372_irregular_coat_pigmentation	0.75874399
99	MP0002234_abnormal_pharynx_morphology	0.75753910
100	MP0009643_abnormal_urine_homeostasis	0.73501726

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	4.44648532
2	Hyperalaninemia (HP:0003348)	4.44648532
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.44648532
4	Acute necrotizing encephalopathy (HP:0006965)	3.58195398
5	Increased CSF lactate (HP:0002490)	3.45675799
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.38150030
7	Acute encephalopathy (HP:0006846)	3.26103601
8	Mitochondrial inheritance (HP:0001427)	3.20995000
9	Stomatitis (HP:0010280)	3.13215356
10	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.06388602
11	Tubular atrophy (HP:0000092)	2.96586366
12	Increased serum lactate (HP:0002151)	2.95780172
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.93262665
14	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.93262665
15	Abnormality of the renal cortex (HP:0011035)	2.93210220
16	Progressive macrocephaly (HP:0004481)	2.91480252
17	Hepatocellular necrosis (HP:0001404)	2.85404878
18	Chronic hepatic failure (HP:0100626)	2.84197490
19	Molar tooth sign on MRI (HP:0002419)	2.81421418
20	Abnormality of midbrain morphology (HP:0002418)	2.81421418
21	IgG deficiency (HP:0004315)	2.80776749
22	Hepatic necrosis (HP:0002605)	2.80259796
23	Increased hepatocellular lipid droplets (HP:0006565)	2.76215627
24	Abnormality of the labia minora (HP:0012880)	2.73264996
25	Poor speech (HP:0002465)	2.65611418
26	Methylmalonic acidemia (HP:0002912)	2.64723473
27	Nephronophthisis (HP:0000090)	2.64680042
28	Lactic acidosis (HP:0003128)	2.60940713
29	Attenuation of retinal blood vessels (HP:0007843)	2.56128274
30	Renal cortical cysts (HP:0000803)	2.54817605
31	Lipid accumulation in hepatocytes (HP:0006561)	2.54503835
32	Methylmalonic aciduria (HP:0012120)	2.52085841
33	Cerebral edema (HP:0002181)	2.48401287
34	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.43813874
35	Pendular nystagmus (HP:0012043)	2.37194043
36	Type I transferrin isoform profile (HP:0003642)	2.34674951
37	Aplasia/hypoplasia of the uterus (HP:0008684)	2.34371086
38	Pancreatic cysts (HP:0001737)	2.32514667
39	Optic disc pallor (HP:0000543)	2.32151842
40	Renal Fanconi syndrome (HP:0001994)	2.29204761
41	Severe combined immunodeficiency (HP:0004430)	2.28135154
42	Abnormal protein N-linked glycosylation (HP:0012347)	2.26896426
43	Abnormal protein glycosylation (HP:0012346)	2.26896426
44	Abnormal glycosylation (HP:0012345)	2.26896426
45	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.26896426
46	Increased intramyocellular lipid droplets (HP:0012240)	2.25774371
47	Abnormality of the renal medulla (HP:0100957)	2.24974849
48	Abnormality of serum amino acid levels (HP:0003112)	2.24672437
49	Generalized aminoaciduria (HP:0002909)	2.24315663
50	Aplastic anemia (HP:0001915)	2.19264139
51	Abnormality of T cells (HP:0002843)	2.18322269
52	Hypoplasia of the pons (HP:0012110)	2.17742548
53	Polydipsia (HP:0001959)	2.14545806
54	Abnormal drinking behavior (HP:0030082)	2.14545806
55	3-Methylglutaconic aciduria (HP:0003535)	2.13842575
56	Abnormality of T cell number (HP:0011839)	2.13837043
57	Abnormal rod and cone electroretinograms (HP:0008323)	2.13051757
58	Abnormality of T cell physiology (HP:0011840)	2.12387070
59	Abnormality of the pons (HP:0007361)	2.10834942
60	Cerebral hypomyelination (HP:0006808)	2.07538151
61	Abolished electroretinogram (ERG) (HP:0000550)	2.05443999
62	Abnormality of urine glucose concentration (HP:0011016)	2.01854743
63	Glycosuria (HP:0003076)	2.01854743
64	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00955105
65	Lethargy (HP:0001254)	2.00897489
66	Congenital stationary night blindness (HP:0007642)	2.00569537
67	Tongue fasciculations (HP:0001308)	1.99324848
68	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.97385110
69	Pancytopenia (HP:0001876)	1.96947451
70	Constricted visual fields (HP:0001133)	1.96343445
71	Hypoalbuminemia (HP:0003073)	1.95510828
72	Abnormal albumin level (HP:0012116)	1.95510828
73	Pancreatic fibrosis (HP:0100732)	1.94797590
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.92508687
75	Short tibia (HP:0005736)	1.92416871
76	CNS hypomyelination (HP:0003429)	1.89716069
77	T lymphocytopenia (HP:0005403)	1.88958244
78	Hypoplasia of the uterus (HP:0000013)	1.87257077
79	Lissencephaly (HP:0001339)	1.86003577
80	Type II lissencephaly (HP:0007260)	1.85888004
81	Progressive inability to walk (HP:0002505)	1.84973259
82	Combined immunodeficiency (HP:0005387)	1.83678134
83	Increased serum pyruvate (HP:0003542)	1.82335150
84	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.81536342
85	Meckel diverticulum (HP:0002245)	1.81026387
86	Type 2 muscle fiber atrophy (HP:0003554)	1.80351243
87	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.79652744
88	Dicarboxylic aciduria (HP:0003215)	1.79652744
89	Absent/shortened dynein arms (HP:0200106)	1.78171516
90	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.78171516
91	Thyroiditis (HP:0100646)	1.77378882
92	Increased IgM level (HP:0003496)	1.76606196
93	Inability to walk (HP:0002540)	1.74101535
94	Abnormality of the ileum (HP:0001549)	1.73124954
95	Absent thumb (HP:0009777)	1.72988206
96	Polyuria (HP:0000103)	1.72741115
97	Increased muscle lipid content (HP:0009058)	1.71547664
98	Progressive microcephaly (HP:0000253)	1.71468677
99	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.70476643
100	Exercise intolerance (HP:0003546)	1.68348045

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.17672494
2	PLK4	2.97301950
3	EIF2AK3	2.89804410
4	BUB1	2.87513880
5	ZAK	2.83829132
6	NUAK1	2.78569017
7	MAP4K2	2.55440898
8	TRIM28	2.47162251
9	VRK2	2.41657871
10	WNK4	2.35248730
11	TSSK6	2.34084386
12	MST4	2.14404860
13	TLK1	2.10563986
14	TTK	2.09518483
15	SRPK1	2.01027259
16	TAOK3	1.94593890
17	ADRBK2	1.85683347
18	MAP3K14	1.83398306
19	TESK2	1.73030750
20	BCKDK	1.71306017
21	BMPR1B	1.70773833
22	EIF2AK1	1.67526675
23	NEK1	1.55851808
24	PLK3	1.54995324
25	VRK1	1.53672709
26	FRK	1.50164224
27	CDC7	1.46635565
28	KDR	1.44530017
29	GRK1	1.43136506
30	PDK2	1.32341504
31	WNK3	1.30740132
32	PHKG2	1.18333930
33	PHKG1	1.18333930
34	LIMK1	1.15159994
35	STK39	1.11610715
36	TAF1	1.11139140
37	INSRR	1.07496902
38	BRSK2	1.07251042
39	MKNK2	1.07032330
40	BCR	1.07002071
41	TESK1	0.99537445
42	MAP4K1	0.98364996
43	ACVR1B	0.96860283
44	PINK1	0.96843684
45	PLK2	0.94562096
46	PLK1	0.93091860
47	PRKCQ	0.92485354
48	EIF2AK2	0.92350103
49	PBK	0.87675366
50	WEE1	0.82878745
51	PNCK	0.82838521
52	DAPK1	0.82230858
53	ATR	0.79226801
54	MAP3K11	0.77145541
55	RPS6KA5	0.76620760
56	OXSR1	0.75255400
57	PASK	0.74384715
58	IKBKB	0.74281444
59	CAMKK2	0.73970607
60	FLT3	0.72142860
61	CSNK1G3	0.69861153
62	DYRK2	0.67398645
63	PRKCI	0.66783819
64	MAPKAPK3	0.64809014
65	FES	0.62158637
66	MATK	0.61652894
67	CDK9	0.60183017
68	NME1	0.59869416
69	IKBKE	0.59540807
70	AURKA	0.59090268
71	ITK	0.56457653
72	AKT3	0.55579623
73	MAP2K6	0.55481499
74	CDK7	0.54136197
75	BRSK1	0.51161873
76	MINK1	0.50080891
77	CSNK1G1	0.49852081
78	PAK3	0.49386617
79	NEK2	0.48933841
80	DAPK2	0.48899048
81	CHEK2	0.48770087
82	CSNK1G2	0.48415924
83	ALK	0.48259769
84	AURKB	0.47554689
85	MKNK1	0.47046504
86	CSNK1A1L	0.44735955
87	PRKCE	0.42659851
88	PRKCG	0.42591123
89	CSNK2A1	0.40548637
90	CHEK1	0.38663575
91	STK16	0.37959517
92	FGFR1	0.36677579
93	CSNK1A1	0.36121228
94	LCK	0.35608129
95	PAK4	0.32076848
96	ADRBK1	0.30493473
97	ATM	0.30422412
98	CSNK2A2	0.29492402
99	RPS6KA4	0.28989539
100	TEC	0.28312198

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.02105724
2	Protein export_Homo sapiens_hsa03060	3.41485478
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.02534542
4	One carbon pool by folate_Homo sapiens_hsa00670	2.84942171
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.72664250
6	RNA polymerase_Homo sapiens_hsa03020	2.62096875
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.21954972
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.21899346
9	Parkinsons disease_Homo sapiens_hsa05012	2.14374542
10	Mismatch repair_Homo sapiens_hsa03430	2.11115498
11	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.05069816
12	Basal transcription factors_Homo sapiens_hsa03022	1.97449299
13	RNA degradation_Homo sapiens_hsa03018	1.88995338
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.88313665
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86875370
16	Homologous recombination_Homo sapiens_hsa03440	1.83389054
17	DNA replication_Homo sapiens_hsa03030	1.80861109
18	RNA transport_Homo sapiens_hsa03013	1.78881436
19	Phototransduction_Homo sapiens_hsa04744	1.64439143
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.61320571
21	Spliceosome_Homo sapiens_hsa03040	1.59016244
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.55221944
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43670903
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.42728991
25	Huntingtons disease_Homo sapiens_hsa05016	1.38971280
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38559225
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.37626684
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.36175351
29	Type I diabetes mellitus_Homo sapiens_hsa04940	1.34126710
30	Purine metabolism_Homo sapiens_hsa00230	1.33506984
31	Sulfur metabolism_Homo sapiens_hsa00920	1.29635817
32	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.28676349
33	Base excision repair_Homo sapiens_hsa03410	1.23646387
34	Graft-versus-host disease_Homo sapiens_hsa05332	1.21263564
35	Alzheimers disease_Homo sapiens_hsa05010	1.17610971
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16752079
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.15911357
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14192499
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14129387
40	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.13615570
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.11310990
42	Antigen processing and presentation_Homo sapiens_hsa04612	1.10919916
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.06809659
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.04649984
45	Regulation of autophagy_Homo sapiens_hsa04140	1.04249235
46	Propanoate metabolism_Homo sapiens_hsa00640	1.01783481
47	Allograft rejection_Homo sapiens_hsa05330	1.00243677
48	Rheumatoid arthritis_Homo sapiens_hsa05323	0.98033034
49	Caffeine metabolism_Homo sapiens_hsa00232	0.96075199
50	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.95600741
51	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.95595536
52	Peroxisome_Homo sapiens_hsa04146	0.94973647
53	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.84156804
54	Nitrogen metabolism_Homo sapiens_hsa00910	0.83212133
55	Ribosome_Homo sapiens_hsa03010	0.82168218
56	Folate biosynthesis_Homo sapiens_hsa00790	0.80468857
57	Olfactory transduction_Homo sapiens_hsa04740	0.77507553
58	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.76290673
59	Fatty acid elongation_Homo sapiens_hsa00062	0.75578098
60	Metabolic pathways_Homo sapiens_hsa01100	0.72141746
61	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.72049083
62	mRNA surveillance pathway_Homo sapiens_hsa03015	0.70821738
63	Linoleic acid metabolism_Homo sapiens_hsa00591	0.69521035
64	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.67065445
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.66974352
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66724162
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63567135
68	Sulfur relay system_Homo sapiens_hsa04122	0.62881738
69	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.59347253
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57140154
71	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.56760345
72	Butanoate metabolism_Homo sapiens_hsa00650	0.56112683
73	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.55833755
74	Cardiac muscle contraction_Homo sapiens_hsa04260	0.55822109
75	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.54716429
76	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.54579999
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52324844
78	Carbon metabolism_Homo sapiens_hsa01200	0.50679995
79	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.48255363
80	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.47512889
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.47491871
82	Legionellosis_Homo sapiens_hsa05134	0.47422165
83	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.46306039
84	Vibrio cholerae infection_Homo sapiens_hsa05110	0.45880248
85	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.45496487
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.44347977
87	Cell cycle_Homo sapiens_hsa04110	0.43882037
88	Morphine addiction_Homo sapiens_hsa05032	0.43395427
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.43086070
90	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.41893676
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41278566
92	Retinol metabolism_Homo sapiens_hsa00830	0.39889721
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39857699
94	p53 signaling pathway_Homo sapiens_hsa04115	0.37036847
95	Nicotine addiction_Homo sapiens_hsa05033	0.36489957
96	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.35239314
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.34552348
98	Measles_Homo sapiens_hsa05162	0.34451283
99	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.34414622
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.34305198

HSPA9P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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