HSPB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.70374425
2bundle of His cell to Purkinje myocyte communication (GO:0086069)6.27095995
3hemidesmosome assembly (GO:0031581)6.14842508
4plasma membrane repair (GO:0001778)5.64666360
5sarcomere organization (GO:0045214)5.01476735
6actin-myosin filament sliding (GO:0033275)5.00823273
7muscle filament sliding (GO:0030049)5.00823273
8regulation of gene silencing by RNA (GO:0060966)4.95486865
9regulation of posttranscriptional gene silencing (GO:0060147)4.95486865
10regulation of gene silencing by miRNA (GO:0060964)4.95486865
11epithelial cell-cell adhesion (GO:0090136)4.57751615
12COPI coating of Golgi vesicle (GO:0048205)4.45986835
13Golgi transport vesicle coating (GO:0048200)4.45986835
14regulation of water loss via skin (GO:0033561)4.29355146
15keratinization (GO:0031424)4.22165493
16actin-mediated cell contraction (GO:0070252)4.21675293
17negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.11615196
18establishment of skin barrier (GO:0061436)4.05813308
19cell-substrate junction assembly (GO:0007044)4.03946880
20establishment of apical/basal cell polarity (GO:0035089)4.00505721
21regulation of skeletal muscle contraction (GO:0014819)4.00034026
22paraxial mesoderm development (GO:0048339)3.87248434
23hair cycle (GO:0042633)3.86116292
24molting cycle (GO:0042303)3.86116292
25regulation of hippo signaling (GO:0035330)3.83461311
26establishment or maintenance of monopolar cell polarity (GO:0061339)3.82555822
27establishment of monopolar cell polarity (GO:0061162)3.82555822
28regulation of cardioblast differentiation (GO:0051890)3.78228813
29apoptotic process involved in morphogenesis (GO:0060561)3.76183704
30ventricular cardiac muscle cell action potential (GO:0086005)3.71825104
31polarized epithelial cell differentiation (GO:0030859)3.70707427
32endothelial cell chemotaxis (GO:0035767)3.70131482
33cardiac myofibril assembly (GO:0055003)3.69880222
34regulation of SMAD protein import into nucleus (GO:0060390)3.64827263
35regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.64734310
36positive regulation of SMAD protein import into nucleus (GO:0060391)3.60710217
37cardiac muscle cell development (GO:0055013)3.55087746
38negative regulation of potassium ion transmembrane transport (GO:1901380)3.52776568
39atrioventricular valve morphogenesis (GO:0003181)3.52253546
40dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.50461130
41ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.49100266
42intermediate filament organization (GO:0045109)3.47958453
43regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.46799057
44protein retention in ER lumen (GO:0006621)3.46271552
45ear development (GO:0043583)3.44422533
46regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.43285187
47cardiac cell development (GO:0055006)3.41951901
48myofibril assembly (GO:0030239)3.38796321
49retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.34437674
50cardiac muscle tissue morphogenesis (GO:0055008)3.34151113
51maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32117465
52regulation of tight junction assembly (GO:2000810)3.29958049
53semaphorin-plexin signaling pathway (GO:0071526)3.29780615
54regulation of cell proliferation involved in kidney development (GO:1901722)3.28228802
55positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.27619255
56peptide cross-linking (GO:0018149)3.26519029
57actomyosin structure organization (GO:0031032)3.25910837
58maternal placenta development (GO:0001893)3.22898201
59regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.22452318
60keratinocyte differentiation (GO:0030216)3.18329546
61actin filament-based movement (GO:0030048)3.13335493
62regulation of translational termination (GO:0006449)3.12802304
63muscle tissue morphogenesis (GO:0060415)3.10902930
64negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.09201759
65gap junction assembly (GO:0016264)3.08642962
66regulation of apoptotic process involved in morphogenesis (GO:1902337)3.06928734
67intestinal epithelial cell development (GO:0060576)3.06031169
68anterior/posterior axis specification, embryo (GO:0008595)3.01329648
69wound healing, spreading of epidermal cells (GO:0035313)3.01225037
70positive regulation of keratinocyte differentiation (GO:0045618)2.98420501
71mammary gland epithelial cell differentiation (GO:0060644)2.97313849
72multicellular organismal water homeostasis (GO:0050891)2.96796480
73trophectodermal cell differentiation (GO:0001829)2.95631414
74adherens junction assembly (GO:0034333)2.94263384
75interferon-gamma secretion (GO:0072643)2.93661043
76basement membrane organization (GO:0071711)2.92933697
77regulation of mammary gland epithelial cell proliferation (GO:0033599)2.92608058
78cell-substrate adherens junction assembly (GO:0007045)2.92488916
79focal adhesion assembly (GO:0048041)2.92488916
80proline biosynthetic process (GO:0006561)2.91158580
81regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.90519166
82cardiac muscle contraction (GO:0060048)2.90439487
83positive regulation of Cdc42 GTPase activity (GO:0043089)2.87023634
84heart valve morphogenesis (GO:0003179)2.86705820
85positive regulation of epidermal cell differentiation (GO:0045606)2.86104320
86epithelial cell differentiation involved in prostate gland development (GO:0060742)2.84191217
87maturation of SSU-rRNA (GO:0030490)2.82412424
88viral transcription (GO:0019083)2.81998313
89cardiac right ventricle morphogenesis (GO:0003215)2.81596548
90regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.80552432
91negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.79312820
92heart trabecula formation (GO:0060347)2.78155213
93NADH metabolic process (GO:0006734)2.77655229
94regulation of translational fidelity (GO:0006450)2.76967097
95apoptotic process involved in development (GO:1902742)2.75669925
96translational termination (GO:0006415)2.73901551
97branching involved in mammary gland duct morphogenesis (GO:0060444)2.73104473
98cell communication involved in cardiac conduction (GO:0086065)2.72866296
99protein maturation by protein folding (GO:0022417)2.71432072
100notochord development (GO:0030903)2.71187971
101cytoskeletal anchoring at plasma membrane (GO:0007016)2.68751245
102formation of translation preinitiation complex (GO:0001731)2.68460220
103outflow tract septum morphogenesis (GO:0003148)2.68367026
104negative regulation of kidney development (GO:0090185)2.66544483
105response to water (GO:0009415)2.66511269
106skin morphogenesis (GO:0043589)2.64532091
107ectoderm development (GO:0007398)2.63715206
108branching involved in salivary gland morphogenesis (GO:0060445)2.63155585
109membrane budding (GO:0006900)2.62298578
110surfactant homeostasis (GO:0043129)2.62088580
111Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.61163895
112positive regulation of epidermis development (GO:0045684)2.60765274
113protein localization to endosome (GO:0036010)2.60498720
114ribosomal small subunit biogenesis (GO:0042274)2.59389525
115mitotic nuclear envelope reassembly (GO:0007084)2.59031731
116nuclear envelope reassembly (GO:0031468)2.59031731
117translational elongation (GO:0006414)2.58795904
118striated muscle contraction (GO:0006941)2.55483262
119negative regulation of striated muscle cell apoptotic process (GO:0010664)2.54686691
120pentose-phosphate shunt (GO:0006098)2.54093681
121epidermal cell differentiation (GO:0009913)2.53629088
122negative regulation of cell fate specification (GO:0009996)2.53533798
123norepinephrine metabolic process (GO:0042415)2.52763875
124planar cell polarity pathway involved in neural tube closure (GO:0090179)2.52709017
125regulation of glucose import in response to insulin stimulus (GO:2001273)2.52610613
126ventricular cardiac muscle cell development (GO:0055015)2.52514493
127carnitine shuttle (GO:0006853)2.51935648
128muscle organ morphogenesis (GO:0048644)2.51415979
129negative regulation of cell size (GO:0045792)2.49976830
130endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.49445321
131skeletal muscle contraction (GO:0003009)2.48653920
132cell proliferation involved in metanephros development (GO:0072203)2.48651039
133trabecula morphogenesis (GO:0061383)2.48277844
134amyloid precursor protein catabolic process (GO:0042987)2.47667607
135adherens junction organization (GO:0034332)2.47501354
136cardiac muscle cell action potential involved in contraction (GO:0086002)2.47140528
137glucose catabolic process (GO:0006007)2.45515464
138regulation of the force of heart contraction (GO:0002026)2.45339519
139negative regulation of fatty acid transport (GO:2000192)2.45041891
140regulation of early endosome to late endosome transport (GO:2000641)2.44809454
141response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.44646805
142tricarboxylic acid cycle (GO:0006099)2.44317493
143nodal signaling pathway (GO:0038092)2.43180541
144regulation of fatty acid beta-oxidation (GO:0031998)2.43156007
145regulation of hair follicle development (GO:0051797)2.42987827
146mesonephros development (GO:0001823)2.42830780
147positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.42454217
148regulation of establishment of planar polarity (GO:0090175)2.41608590
149oxidative phosphorylation (GO:0006119)2.41489345
150renal filtration (GO:0097205)2.41346022
151regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.40636603
152embryo implantation (GO:0007566)2.40218743
153barbed-end actin filament capping (GO:0051016)2.39972745
154regulation of p38MAPK cascade (GO:1900744)2.39619012
155translational initiation (GO:0006413)2.39268145
156regulation of protein localization to cell surface (GO:2000008)2.39190147
157striated muscle cell development (GO:0055002)2.39155220
158cardiac muscle cell action potential (GO:0086001)2.39020094
159embryonic process involved in female pregnancy (GO:0060136)2.38716628
160negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.38562023
161negative regulation of chondrocyte differentiation (GO:0032331)2.37842213
162water homeostasis (GO:0030104)2.37408538
163negative regulation of adherens junction organization (GO:1903392)2.36949968
164negative regulation of focal adhesion assembly (GO:0051895)2.36949968
165negative regulation of cell junction assembly (GO:1901889)2.36949968
166activation of Rac GTPase activity (GO:0032863)2.36824974
167cell-cell junction maintenance (GO:0045217)2.35760489
168negative regulation of embryonic development (GO:0045992)2.35264038
169positive regulation of receptor recycling (GO:0001921)2.33249985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.97323791
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.58614692
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.58614692
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.58614692
5* NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.10115801
6* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.93538369
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.90514036
8ZNF263_19887448_ChIP-Seq_K562_Human2.83251872
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.69439076
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67810589
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54723666
12STAT3_1855785_ChIP-Seq_MESCs_Mouse2.38166271
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.34765131
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.33377505
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32719710
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.30063462
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.29535067
18* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.26635805
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.23624163
20NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.17339552
21ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.15270213
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.14919034
23KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.12626019
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11894859
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.07474899
26TRIM28_21343339_ChIP-Seq_HEK293_Human2.07204375
27ESR1_21235772_ChIP-Seq_MCF-7_Human2.01104901
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.99347723
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97205791
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.91247775
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89524911
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.89140035
33SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.85812137
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81133051
35* ATF3_27146783_Chip-Seq_COLON_Human1.76435749
36* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71858422
37* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70635073
38* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.69338178
39* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.67149298
40CLOCK_20551151_ChIP-Seq_293T_Human1.66490234
41NANOG_18692474_ChIP-Seq_MEFs_Mouse1.64153282
42VDR_21846776_ChIP-Seq_THP-1_Human1.62827518
43E2F7_22180533_ChIP-Seq_HELA_Human1.62238862
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.59311626
45* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56662712
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55184600
47* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50860184
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49503168
49* RACK7_27058665_Chip-Seq_MCF-7_Human1.48136766
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47357749
51P68_20966046_ChIP-Seq_HELA_Human1.47316550
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.46748893
53* KDM2B_26808549_Chip-Seq_DND41_Human1.46344277
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46115505
55* ELK3_25401928_ChIP-Seq_HUVEC_Human1.45439653
56* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.44461204
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44358770
58* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42622190
59* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42622190
60* KDM2B_26808549_Chip-Seq_K562_Human1.42256538
61* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41264817
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41218027
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41128533
64SMC4_20622854_ChIP-Seq_HELA_Human1.39830282
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39805814
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38158062
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37652298
68* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.37234160
69* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.36860767
70* SA1_27219007_Chip-Seq_ERYTHROID_Human1.36781317
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36327209
72TCF7_22412390_ChIP-Seq_EML_Mouse1.33278687
73* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33037743
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32576248
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32296260
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32042909
77* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31692080
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31479513
79CREB1_26743006_Chip-Seq_LNCaP_Human1.30360343
80* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29830072
81* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29676014
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28960237
83CTCF_27219007_Chip-Seq_Bcells_Human1.27659729
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25001451
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24890872
86POU5F1_16518401_ChIP-PET_MESCs_Mouse1.24413453
87NANOG_18692474_ChIP-Seq_MESCs_Mouse1.24410510
88* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24061774
89* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18936888
90* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.18641580
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.18090822
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17619045
93MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17615422
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17464229
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16980459
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16892212
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16841708
98FOXM1_23109430_ChIP-Seq_U2OS_Human1.15697954
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15639311
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15165374
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12455176
102* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.12343584
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11720690
104PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10861133
105SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09226147
106TBX20_22328084_ChIP-Seq_HEART_Mouse1.09051126
107TBX20_22080862_ChIP-Seq_HEART_Mouse1.09051126
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08979501
109* FOXO3_23340844_ChIP-Seq_DLD1_Human1.08751595
110MYC_22102868_ChIP-Seq_BL_Human1.08376801
111* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07276075
112* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05859864
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05772426
114* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05740628
115TP53_22127205_ChIP-Seq_IMR90_Human1.04516624
116RXR_22158963_ChIP-Seq_LIVER_Mouse1.02034659
117* RUNX1_27514584_Chip-Seq_MCF-7_Human1.01637373
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00987998
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00855216
120* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00301753
121TET1_21490601_ChIP-Seq_MESCs_Mouse0.99845491
122SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98193617
123HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96604214
124XRN2_22483619_ChIP-Seq_HELA_Human0.96413395
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95564869
126* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95342858
127LXR_22292898_ChIP-Seq_THP-1_Human0.94173317
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.93568111
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93197735
130CTCF_26484167_Chip-Seq_Bcells_Mouse0.93046350
131GATA3_24758297_ChIP-Seq_MCF-7_Human0.92970676
132CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92952625
133UBF1/2_26484160_Chip-Seq_HMECs_Human0.92694836
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92386753
135BCOR_27268052_Chip-Seq_Bcells_Human0.92070898
136STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91001354
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.90445411
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90142561
139RARB_24833708_ChIP-Seq_LIVER_Mouse0.89892865
140GATA6_25053715_ChIP-Seq_YYC3_Human0.89767762
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89045459
142POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87912529
143PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87699735
144* TP63_22573176_ChIP-Seq_HFKS_Human0.87189150
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86606180
146* KAP1_27257070_Chip-Seq_ESCs_Mouse0.86162677
147ELK1_22589737_ChIP-Seq_MCF10A_Human0.85398155
148P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84927645
149TP53_20018659_ChIP-ChIP_R1E_Mouse0.84067574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.89286953
2MP0002796_impaired_skin_barrier3.77852295
3MP0005275_abnormal_skin_tensile3.61519005
4MP0004084_abnormal_cardiac_muscle3.32728827
5MP0003705_abnormal_hypodermis_morpholog3.25235797
6MP0003566_abnormal_cell_adhesion2.90090472
7MP0000751_myopathy2.68450619
8MP0000749_muscle_degeneration2.62235567
9MP0010234_abnormal_vibrissa_follicle2.61565554
10MP0002837_dystrophic_cardiac_calcinosis2.59516471
11MP0000750_abnormal_muscle_regeneration2.59086284
12MP0005501_abnormal_skin_physiology2.51335976
13MP0009780_abnormal_chondrocyte_physiolo2.37034580
14MP0010352_gastrointestinal_tract_polyps2.31777431
15MP0004036_abnormal_muscle_relaxation2.13283507
16MP0005330_cardiomyopathy2.12523168
17MP0004381_abnormal_hair_follicle2.05437105
18MP0004087_abnormal_muscle_fiber2.01307476
19MP0002254_reproductive_system_inflammat1.94518824
20MP0002060_abnormal_skin_morphology1.89088822
21MP0004272_abnormal_basement_membrane1.88556260
22MP0003806_abnormal_nucleotide_metabolis1.88050398
23MP0010030_abnormal_orbit_morphology1.87688663
24MP0003646_muscle_fatigue1.85805321
25MP0005409_darkened_coat_color1.80951928
26MP0005451_abnormal_body_composition1.80712617
27MP0005257_abnormal_intraocular_pressure1.74216838
28MP0002269_muscular_atrophy1.74208314
29MP0002249_abnormal_larynx_morphology1.72668558
30MP0008775_abnormal_heart_ventricle1.67649772
31MP0003453_abnormal_keratinocyte_physiol1.65842018
32MP0005023_abnormal_wound_healing1.65106499
33MP0005058_abnormal_lysosome_morphology1.63860352
34MP0005503_abnormal_tendon_morphology1.63604545
35MP0010630_abnormal_cardiac_muscle1.63178894
36MP0008438_abnormal_cutaneous_collagen1.62692784
37MP0004215_abnormal_myocardial_fiber1.61748591
38MP0000566_synostosis1.61303182
39MP0009384_cardiac_valve_regurgitation1.61224859
40MP0002972_abnormal_cardiac_muscle1.59100271
41MP0000762_abnormal_tongue_morphology1.56665953
42MP0005623_abnormal_meninges_morphology1.53146270
43MP0003828_pulmonary_edema1.48990625
44MP0006138_congestive_heart_failure1.48671269
45MP0003950_abnormal_plasma_membrane1.48101912
46MP0002106_abnormal_muscle_physiology1.47215671
47MP0001216_abnormal_epidermal_layer1.43745173
48MP0000759_abnormal_skeletal_muscle1.43714288
49MP0000579_abnormal_nail_morphology1.42937376
50MP0000747_muscle_weakness1.42454685
51MP0005620_abnormal_muscle_contractility1.40655257
52MP0000467_abnormal_esophagus_morphology1.40269012
53MP0003191_abnormal_cellular_cholesterol1.39346100
54MP0003279_aneurysm1.38603801
55MP0005385_cardiovascular_system_phenoty1.37688512
56MP0001544_abnormal_cardiovascular_syste1.37688512
57MP0004185_abnormal_adipocyte_glucose1.36848755
58MP0010771_integument_phenotype1.34950784
59MP0000678_abnormal_parathyroid_gland1.33776086
60MP0004133_heterotaxia1.31596946
61MP0000733_abnormal_muscle_development1.27198562
62MP0004145_abnormal_muscle_electrophysio1.26832060
63MP0004858_abnormal_nervous_system1.25343339
64MP0001849_ear_inflammation1.25204123
65MP0009840_abnormal_foam_cell1.24480426
66MP0000003_abnormal_adipose_tissue1.23835552
67MP0000462_abnormal_digestive_system1.22673367
68MP0005369_muscle_phenotype1.22461735
69MP0004233_abnormal_muscle_weight1.22021562
70MP0002877_abnormal_melanocyte_morpholog1.18910547
71MP0004957_abnormal_blastocyst_morpholog1.18633113
72MP0005083_abnormal_biliary_tract1.16767137
73MP0000537_abnormal_urethra_morphology1.16610442
74MP0002332_abnormal_exercise_endurance1.15108655
75MP0002127_abnormal_cardiovascular_syste1.13114498
76MP0000013_abnormal_adipose_tissue1.12074172
77MP0002098_abnormal_vibrissa_morphology1.11560606
78MP0008260_abnormal_autophagy1.09565586
79MP0000627_abnormal_mammary_gland1.08850696
80MP0003567_abnormal_fetal_cardiomyocyte1.07712463
81MP0000534_abnormal_ureter_morphology1.07069193
82MP0005666_abnormal_adipose_tissue1.05685138
83MP0004484_altered_response_of1.05541447
84MP0005670_abnormal_white_adipose1.04692749
85MP0009053_abnormal_anal_canal1.04560867
86MP0002089_abnormal_postnatal_growth/wei1.03790139
87MP0005508_abnormal_skeleton_morphology1.03358794
88MP0009379_abnormal_foot_pigmentation1.01130021
89MP0000377_abnormal_hair_follicle1.00182439
90MP0003137_abnormal_impulse_conducting0.98508780
91MP0004782_abnormal_surfactant_physiolog0.98071909
92MP0005076_abnormal_cell_differentiation0.96977973
93MP0000767_abnormal_smooth_muscle0.96534734
94MP0004510_myositis0.95980011
95MP0002653_abnormal_ependyma_morphology0.95868527
96MP0002896_abnormal_bone_mineralization0.95372318
97MP0002234_abnormal_pharynx_morphology0.95185554
98MP0000647_abnormal_sebaceous_gland0.94981985
99MP0003221_abnormal_cardiomyocyte_apopto0.94840246
100MP0004197_abnormal_fetal_growth/weight/0.94129291
101MP0010368_abnormal_lymphatic_system0.89367313
102MP0010678_abnormal_skin_adnexa0.88237096
103MP0005165_increased_susceptibility_to0.87606644
104MP0005380_embryogenesis_phenotype0.85778253
105MP0001672_abnormal_embryogenesis/_devel0.85778253
106MP0002086_abnormal_extraembryonic_tissu0.85249259
107MP0000516_abnormal_urinary_system0.84973113
108MP0005367_renal/urinary_system_phenotyp0.84973113
109MP0000427_abnormal_hair_cycle0.84614778
110MP0001730_embryonic_growth_arrest0.84399026
111MP0003984_embryonic_growth_retardation0.84180976
112MP0002088_abnormal_embryonic_growth/wei0.84172570
113MP0002084_abnormal_developmental_patter0.83941767
114MP0001881_abnormal_mammary_gland0.82773987
115MP0000266_abnormal_heart_morphology0.80644053
116MP0000383_abnormal_hair_follicle0.80522415
117MP0003693_abnormal_embryo_hatching0.79802009
118MP0000343_altered_response_to0.79722601
119MP0002085_abnormal_embryonic_tissue0.79469823
120MP0003942_abnormal_urinary_system0.79259541
121MP0002108_abnormal_muscle_morphology0.79239653
122MP0001243_abnormal_dermal_layer0.78479113
123MP0009931_abnormal_skin_appearance0.78301148
124MP0004264_abnormal_extraembryonic_tissu0.77808102
125MP0002925_abnormal_cardiovascular_devel0.77254416
126MP0005375_adipose_tissue_phenotype0.76893065
127MP0000350_abnormal_cell_proliferation0.74481750
128MP0001958_emphysema0.73701250
129MP0003091_abnormal_cell_migration0.72706875
130MP0001697_abnormal_embryo_size0.70995041
131MP0001348_abnormal_lacrimal_gland0.70394601
132MP0000367_abnormal_coat/_hair0.66164892
133MP0003123_paternal_imprinting0.65445915
134MP0001340_abnormal_eyelid_morphology0.64764098
135MP0000858_altered_metastatic_potential0.64264503
136MP0000681_abnormal_thyroid_gland0.59408235
137MP0000538_abnormal_urinary_bladder0.58572714
138MP0001542_abnormal_bone_strength0.58016631
139MP0003638_abnormal_response/metabolism_0.58015635

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.29781386
2Ventricular tachycardia (HP:0004756)5.02120276
3Muscle fiber splitting (HP:0003555)4.82282922
4Increased connective tissue (HP:0009025)4.74346628
5* Hyporeflexia of lower limbs (HP:0002600)4.50044123
6Sudden death (HP:0001699)4.48686520
7Type 1 muscle fiber predominance (HP:0003803)3.79624159
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.76416420
9Difficulty climbing stairs (HP:0003551)3.68235659
10Muscle fiber inclusion bodies (HP:0100299)3.63121140
11Hypotrichosis (HP:0001006)3.59009098
12Abnormality of nail color (HP:0100643)3.55111077
13Exercise-induced muscle cramps (HP:0003710)3.49313479
14Distal arthrogryposis (HP:0005684)3.44914083
15Hyperacusis (HP:0010780)3.35304912
16* Distal lower limb muscle weakness (HP:0009053)3.29935764
17Nemaline bodies (HP:0003798)3.26544788
18EMG: myopathic abnormalities (HP:0003458)3.19437625
19Round ear (HP:0100830)3.14727840
20Abnormality of the calf musculature (HP:0001430)3.14456137
21Woolly hair (HP:0002224)3.05716434
22Difficulty running (HP:0009046)3.00455866
23Exercise-induced myalgia (HP:0003738)2.98344794
24Calf muscle hypertrophy (HP:0008981)2.97072669
25J-shaped sella turcica (HP:0002680)2.90536240
26Onycholysis (HP:0001806)2.85530950
27Trismus (HP:0000211)2.83134903
28Lipoatrophy (HP:0100578)2.80296891
29Fragile nails (HP:0001808)2.76409564
30Milia (HP:0001056)2.73305332
31Atrophic scars (HP:0001075)2.73033490
32Nail dystrophy (HP:0008404)2.72730190
33Popliteal pterygium (HP:0009756)2.70372039
34Mildly elevated creatine phosphokinase (HP:0008180)2.65789241
35Muscle hypertrophy of the lower extremities (HP:0008968)2.63738591
36Spinal rigidity (HP:0003306)2.63362260
37Abnormal hemoglobin (HP:0011902)2.61812866
38Centrally nucleated skeletal muscle fibers (HP:0003687)2.61795421
39Distal lower limb amyotrophy (HP:0008944)2.61197430
40Vertebral compression fractures (HP:0002953)2.57432930
41Plantar hyperkeratosis (HP:0007556)2.56115548
42Pili torti (HP:0003777)2.54483636
43Myopathic facies (HP:0002058)2.54408842
44Broad face (HP:0000283)2.52119975
45Atrial fibrillation (HP:0005110)2.51683592
46Abnormality of skeletal muscle fiber size (HP:0012084)2.49780756
47Protrusio acetabuli (HP:0003179)2.48946227
48Myotonia (HP:0002486)2.48550069
49Neck muscle weakness (HP:0000467)2.47726199
50Increased variability in muscle fiber diameter (HP:0003557)2.45692294
51Palmoplantar keratoderma (HP:0000982)2.44038218
52Palpitations (HP:0001962)2.42739040
53Generalized amyotrophy (HP:0003700)2.42012808
54Advanced eruption of teeth (HP:0006288)2.41596322
55Bladder diverticulum (HP:0000015)2.41535016
56* Areflexia of lower limbs (HP:0002522)2.40518033
57Pterygium (HP:0001059)2.39924987
58Scapular winging (HP:0003691)2.39919228
59Supraventricular arrhythmia (HP:0005115)2.39562283
60Primary atrial arrhythmia (HP:0001692)2.38769315
61Abnormality of the Achilles tendon (HP:0005109)2.37691470
62Myoglobinuria (HP:0002913)2.36931723
63Ventricular arrhythmia (HP:0004308)2.35969999
64Supraventricular tachycardia (HP:0004755)2.34231295
65Testicular atrophy (HP:0000029)2.33941223
66Dilated cardiomyopathy (HP:0001644)2.32872555
67Natal tooth (HP:0000695)2.31314177
68Premature rupture of membranes (HP:0001788)2.27848855
69Axonal loss (HP:0003447)2.27308960
70Abnormality of the salivary glands (HP:0010286)2.26328841
71Selective tooth agenesis (HP:0001592)2.25734920
72Ulnar deviation of the wrist (HP:0003049)2.25237235
73Rhabdomyolysis (HP:0003201)2.24572113
74Bulbar palsy (HP:0001283)2.24517402
75Elbow flexion contracture (HP:0002987)2.20113809
76Abnormal hair laboratory examination (HP:0003328)2.19995491
77Subaortic stenosis (HP:0001682)2.19382161
78Abnormality of the left ventricular outflow tract (HP:0011103)2.19382161
79Ankle contracture (HP:0006466)2.19319968
80Ulnar bowing (HP:0003031)2.17414175
81Curly hair (HP:0002212)2.15844290
82Short nail (HP:0001799)2.14520245
83Asymmetry of the thorax (HP:0001555)2.14509320
84Cerebral aneurysm (HP:0004944)2.14441991
85Stridor (HP:0010307)2.12541055
86Septate vagina (HP:0001153)2.11581354
87Bundle branch block (HP:0011710)2.10587735
88Abnormality of the distal phalanges of the toes (HP:0010182)2.08651622
89Thick nail (HP:0001805)2.06660151
90Syncope (HP:0001279)2.05853170
91Cervical subluxation (HP:0003308)2.04999293
92Lip pit (HP:0100267)2.04960298
93Shallow orbits (HP:0000586)2.04915244
94Achilles tendon contracture (HP:0001771)2.04707018
95Acanthosis nigricans (HP:0000956)2.03620186
96Limb-girdle muscle atrophy (HP:0003797)2.02921704
97Palmoplantar hyperkeratosis (HP:0000972)2.01516819
98Fused cervical vertebrae (HP:0002949)1.98583690
99Fragile skin (HP:0001030)1.98248171
100Hyperparathyroidism (HP:0000843)1.97985500
101Fatigable weakness (HP:0003473)1.97940664
102Abnormality of the neuromuscular junction (HP:0003398)1.97940664
103Mitral regurgitation (HP:0001653)1.97737811
104Ridged nail (HP:0001807)1.97694650
105Lymphangioma (HP:0100764)1.97662411
106Abnormality of the calcaneus (HP:0008364)1.97461998
107Upper limb amyotrophy (HP:0009129)1.97356536
108Distal upper limb amyotrophy (HP:0007149)1.97356536
109Back pain (HP:0003418)1.97309419
110Thin bony cortex (HP:0002753)1.97046745
111Ventricular fibrillation (HP:0001663)1.96926864
112Palmar hyperkeratosis (HP:0010765)1.96549924
113Malignant hyperthermia (HP:0002047)1.96537967
114Muscular dystrophy (HP:0003560)1.96029188
115Wrist flexion contracture (HP:0001239)1.94197907
116Lower limb amyotrophy (HP:0007210)1.93735482
117Insomnia (HP:0100785)1.92161245
118Muscle stiffness (HP:0003552)1.91156159
119Mesangial abnormality (HP:0001966)1.90793933
120Ependymoma (HP:0002888)1.88593406
121Alopecia of scalp (HP:0002293)1.86388473
122Osteolytic defects of the phalanges of the hand (HP:0009771)1.86236138
123Osteolytic defects of the hand bones (HP:0009699)1.86236138
124Asymmetric septal hypertrophy (HP:0001670)1.85869974
125Easy fatigability (HP:0003388)1.85758773
126Hip contracture (HP:0003273)1.85382326
127Calcaneovalgus deformity (HP:0001848)1.84819947
128Sparse eyelashes (HP:0000653)1.84368379
129Aplasia/hypoplasia of the humerus (HP:0006507)1.84010650
130Long toe (HP:0010511)1.83661716
131Hydroureter (HP:0000072)1.83175109
132Blue sclerae (HP:0000592)1.82646848
133Vascular tortuosity (HP:0004948)1.82194978
134Abnormal atrioventricular conduction (HP:0005150)1.82186236
135Congenital ichthyosiform erythroderma (HP:0007431)1.81045754
136* Foot dorsiflexor weakness (HP:0009027)1.80962715
137Abnormality of the umbilical cord (HP:0010881)1.80784534
138Arterial tortuosity (HP:0005116)1.79024420
139* Abnormality of the foot musculature (HP:0001436)1.78812639
140Abnormal blistering of the skin (HP:0008066)1.77752163
141Short humerus (HP:0005792)1.77366018
142* EMG: neuropathic changes (HP:0003445)1.76941714
143Wormian bones (HP:0002645)1.74877487
144Nuclear cataract (HP:0100018)1.73705995

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.53176649
2TTN4.33065135
3SIK13.55852067
4LATS22.76011059
5NEK12.67666033
6SMG12.63609230
7LIMK12.24053366
8FER2.21547039
9OBSCN2.21193589
10MAP3K32.19609983
11TESK12.15438821
12PKN22.10817933
13MUSK2.06182156
14TRIB32.02358020
15LMTK22.01265486
16MYLK1.92936192
17STK38L1.88263398
18PDK31.72586327
19PDK41.72586327
20IRAK31.71439986
21CDK121.69049888
22PDK21.62760258
23BCKDK1.58676694
24PHKG21.52265991
25PHKG11.52265991
26VRK21.50479686
27ARAF1.46761521
28LRRK21.45882295
29LATS11.41238605
30MAP3K111.32902353
31TSSK61.32862259
32AKT31.32597222
33PIM21.29572010
34MST41.27317173
35DMPK1.27189124
36MET1.26388650
37PIK3CG1.25305790
38STK101.23790450
39RIPK11.23577612
40EPHB21.21448965
41ERN11.19131236
42PAK41.17422115
43TRPM71.15790506
44WEE11.15312990
45RPS6KA21.10508408
46* RPS6KB21.09762123
47PRKD21.08611941
48MAP2K31.07511379
49PRPF4B1.06415454
50BUB11.05090588
51PTK21.04969550
52TIE11.02038970
53CAMK2G0.99650540
54TTK0.98744517
55KDR0.96632723
56PDGFRA0.96425225
57MTOR0.96273255
58NTRK10.96233831
59PRKD30.95996354
60MAP2K10.95877108
61EEF2K0.95509658
62ILK0.95207271
63CDC42BPA0.95141824
64MAP2K20.94851351
65DDR20.92689410
66MAP3K80.91639010
67PRKCI0.89682294
68PAK20.88696328
69DAPK30.88666815
70NME20.87335712
71ZAK0.86045387
72ROCK10.84896189
73TGFBR10.84190031
74TGFBR20.82290123
75TESK20.82243917
76CDK70.82207765
77PAK30.81296462
78TBK10.77351721
79AURKA0.76363313
80FLT30.75270569
81MAP3K60.74164354
82PTK60.70887134
83ABL20.70272937
84STK240.68781021
85STK380.66826961
86CAMK2B0.65624484
87MATK0.65257548
88PRKG20.64753849
89BMX0.64476039
90ROCK20.63076751
91PDPK10.62893518
92CAMK2D0.62724053
93EPHB10.62490716
94TAOK10.60435681
95AURKB0.57680246
96AKT20.57462097
97PIK3CA0.56510688
98EPHA30.56324289
99NEK60.55654046
100MAP3K50.55615773
101FGFR10.52654688
102MAPK120.52482713
103MAPKAPK50.51696615
104RET0.49762708
105RPS6KA60.49742691
106MAP3K10.49042807
107BRAF0.48898512
108PAK10.48339085
109HIPK20.48163307
110MST1R0.48093144
111RPS6KA40.48054208
112* PRKD10.47928733
113GRK60.45857237
114ICK0.45656270
115SCYL20.45622102
116MAPK150.43339311
117NME10.43142756
118MOS0.42821973
119MAP3K20.42593403
120FGFR40.42552428
121RPS6KL10.42118744
122RPS6KC10.42118744
123CDK60.41466476
124CDK80.40842299
125TAOK20.40297577
126CHUK0.39921814
127MAP3K120.39342466
128ALK0.38943031
129MAP3K90.38834803
130* MAPKAPK20.37799441
131CSNK1E0.36969593
132STK40.36630953
133PLK10.36489808
134MAPK40.34780558
135KSR20.34428782
136MARK20.31467848

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.32992074
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.20210717
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.07055152
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.01211516
5Dilated cardiomyopathy_Homo sapiens_hsa054142.77821303
6Ribosome_Homo sapiens_hsa030102.69467682
7Cardiac muscle contraction_Homo sapiens_hsa042602.49569298
8Pentose phosphate pathway_Homo sapiens_hsa000302.47946398
9Tight junction_Homo sapiens_hsa045302.14509223
10ECM-receptor interaction_Homo sapiens_hsa045122.10677494
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06736710
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.02381290
13Adherens junction_Homo sapiens_hsa045201.97217926
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96188689
15Hippo signaling pathway_Homo sapiens_hsa043901.93250872
16p53 signaling pathway_Homo sapiens_hsa041151.75011395
17Carbon metabolism_Homo sapiens_hsa012001.72246030
18Prion diseases_Homo sapiens_hsa050201.71831152
19Focal adhesion_Homo sapiens_hsa045101.68225410
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65384092
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64074947
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.59636448
23Bladder cancer_Homo sapiens_hsa052191.59407924
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59396553
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55800243
26Biosynthesis of amino acids_Homo sapiens_hsa012301.55193048
27Other glycan degradation_Homo sapiens_hsa005111.50580502
28Basal cell carcinoma_Homo sapiens_hsa052171.44477747
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41889159
30Proteasome_Homo sapiens_hsa030501.41131415
31Proteoglycans in cancer_Homo sapiens_hsa052051.36874313
32TGF-beta signaling pathway_Homo sapiens_hsa043501.35703987
33RNA transport_Homo sapiens_hsa030131.35222700
34Parkinsons disease_Homo sapiens_hsa050121.29111823
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24728844
36Estrogen signaling pathway_Homo sapiens_hsa049151.23719834
37Endometrial cancer_Homo sapiens_hsa052131.21805619
38Small cell lung cancer_Homo sapiens_hsa052221.20004974
39One carbon pool by folate_Homo sapiens_hsa006701.17399557
40Vibrio cholerae infection_Homo sapiens_hsa051101.17120350
41Hedgehog signaling pathway_Homo sapiens_hsa043401.17036453
42Oxidative phosphorylation_Homo sapiens_hsa001901.16866559
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.16347528
44Chronic myeloid leukemia_Homo sapiens_hsa052201.15981648
45Viral myocarditis_Homo sapiens_hsa054161.14964443
46Thyroid cancer_Homo sapiens_hsa052161.13170806
47HIF-1 signaling pathway_Homo sapiens_hsa040661.10077621
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09934719
49Mismatch repair_Homo sapiens_hsa034301.09788066
50* VEGF signaling pathway_Homo sapiens_hsa043701.08602743
51Huntingtons disease_Homo sapiens_hsa050161.06616128
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04843810
53Glioma_Homo sapiens_hsa052141.04065027
54Tyrosine metabolism_Homo sapiens_hsa003501.03453592
55Glutathione metabolism_Homo sapiens_hsa004801.02880265
56Renal cell carcinoma_Homo sapiens_hsa052111.01271780
57Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00549074
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00241985
59Fatty acid elongation_Homo sapiens_hsa000620.98690550
60MicroRNAs in cancer_Homo sapiens_hsa052060.95303003
61Fatty acid degradation_Homo sapiens_hsa000710.92175126
62ErbB signaling pathway_Homo sapiens_hsa040120.91213276
63Arginine biosynthesis_Homo sapiens_hsa002200.89706024
64DNA replication_Homo sapiens_hsa030300.89238873
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88659640
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.87177462
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84778009
68RNA polymerase_Homo sapiens_hsa030200.83928100
69Spliceosome_Homo sapiens_hsa030400.83546498
70Lysosome_Homo sapiens_hsa041420.83058908
71Non-small cell lung cancer_Homo sapiens_hsa052230.81353374
72Fructose and mannose metabolism_Homo sapiens_hsa000510.81081775
73Melanogenesis_Homo sapiens_hsa049160.80140957
74Endocytosis_Homo sapiens_hsa041440.79543620
75Pyruvate metabolism_Homo sapiens_hsa006200.79493211
76* Amoebiasis_Homo sapiens_hsa051460.78471239
77GnRH signaling pathway_Homo sapiens_hsa049120.78228734
78Arachidonic acid metabolism_Homo sapiens_hsa005900.77827251
79Hepatitis C_Homo sapiens_hsa051600.77445495
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76174565
81Propanoate metabolism_Homo sapiens_hsa006400.76061789
82Melanoma_Homo sapiens_hsa052180.75772768
83Notch signaling pathway_Homo sapiens_hsa043300.73809080
84Pathways in cancer_Homo sapiens_hsa052000.73550601
85Alzheimers disease_Homo sapiens_hsa050100.72643979
86Axon guidance_Homo sapiens_hsa043600.72533888
87Protein digestion and absorption_Homo sapiens_hsa049740.71005221
88Insulin signaling pathway_Homo sapiens_hsa049100.70212115
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69994804
90Pancreatic cancer_Homo sapiens_hsa052120.69677933
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69650459
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68561912
93Cell cycle_Homo sapiens_hsa041100.67687588
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.67564985
95Arginine and proline metabolism_Homo sapiens_hsa003300.67038802
96N-Glycan biosynthesis_Homo sapiens_hsa005100.66915711
97Galactose metabolism_Homo sapiens_hsa000520.66455053
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66245022
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65196445
100Insulin resistance_Homo sapiens_hsa049310.64774206
101Phenylalanine metabolism_Homo sapiens_hsa003600.63792199
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61063742
103Glucagon signaling pathway_Homo sapiens_hsa049220.60220164
104Nucleotide excision repair_Homo sapiens_hsa034200.59335748
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59260991
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58396238
107Linoleic acid metabolism_Homo sapiens_hsa005910.58284482
108HTLV-I infection_Homo sapiens_hsa051660.57031457
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54723503
110mTOR signaling pathway_Homo sapiens_hsa041500.54396848
111Rap1 signaling pathway_Homo sapiens_hsa040150.52792371
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.52585686
113Prostate cancer_Homo sapiens_hsa052150.52282369
114Apoptosis_Homo sapiens_hsa042100.50949408
115Bile secretion_Homo sapiens_hsa049760.50634570
116Choline metabolism in cancer_Homo sapiens_hsa052310.50248377
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50113702
118Viral carcinogenesis_Homo sapiens_hsa052030.50087268
119AMPK signaling pathway_Homo sapiens_hsa041520.49454921
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49048027
121Gastric acid secretion_Homo sapiens_hsa049710.48028445
122Fat digestion and absorption_Homo sapiens_hsa049750.47306166
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45920710
124Ovarian steroidogenesis_Homo sapiens_hsa049130.45679651
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44940901
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.44119502
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40871133
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40254057
129* Epstein-Barr virus infection_Homo sapiens_hsa051690.40102105
130Folate biosynthesis_Homo sapiens_hsa007900.39829426
131Sphingolipid metabolism_Homo sapiens_hsa006000.39633379
132Wnt signaling pathway_Homo sapiens_hsa043100.39504573
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.38191299
134Toxoplasmosis_Homo sapiens_hsa051450.37592072
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36962479
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36813539
137Acute myeloid leukemia_Homo sapiens_hsa052210.35455758
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34828930
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34664524
140Sulfur relay system_Homo sapiens_hsa041220.34424757
141Base excision repair_Homo sapiens_hsa034100.32975057
142Starch and sucrose metabolism_Homo sapiens_hsa005000.31347301
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.30860755
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30636316

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