HSPB11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.35454117
2ATP synthesis coupled proton transport (GO:0015986)5.62971410
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.62971410
4proteasome assembly (GO:0043248)5.11814549
5central nervous system myelination (GO:0022010)4.84721631
6axon ensheathment in central nervous system (GO:0032291)4.84721631
7respiratory electron transport chain (GO:0022904)4.74210044
8electron transport chain (GO:0022900)4.69360708
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.50386203
10protein complex biogenesis (GO:0070271)4.38232120
11chaperone-mediated protein transport (GO:0072321)4.18127979
12mitochondrial respiratory chain complex assembly (GO:0033108)4.15874112
13long-chain fatty acid biosynthetic process (GO:0042759)4.15002241
14CENP-A containing nucleosome assembly (GO:0034080)4.02727631
15limb bud formation (GO:0060174)4.01501727
16presynaptic membrane assembly (GO:0097105)4.00592133
17chromatin remodeling at centromere (GO:0031055)4.00183352
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.98704814
19NADH dehydrogenase complex assembly (GO:0010257)3.98704814
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.98704814
21respiratory chain complex IV assembly (GO:0008535)3.95755468
22DNA deamination (GO:0045006)3.95138760
23cytochrome complex assembly (GO:0017004)3.77390056
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.71930171
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.69425853
26presynaptic membrane organization (GO:0097090)3.63261702
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.63096669
28DNA double-strand break processing (GO:0000729)3.59929870
29regulation of mitochondrial translation (GO:0070129)3.52251218
30preassembly of GPI anchor in ER membrane (GO:0016254)3.52049580
31GPI anchor biosynthetic process (GO:0006506)3.43587748
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.43389462
33cullin deneddylation (GO:0010388)3.42229260
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.41408016
35pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.41077014
36DNA replication checkpoint (GO:0000076)3.37306863
37termination of RNA polymerase III transcription (GO:0006386)3.36412643
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.36412643
39ATP biosynthetic process (GO:0006754)3.34913448
40histone exchange (GO:0043486)3.31022059
41superoxide anion generation (GO:0042554)3.29948310
42telomere maintenance via semi-conservative replication (GO:0032201)3.29859168
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29390315
44oxidative phosphorylation (GO:0006119)3.28377745
45purine nucleoside triphosphate biosynthetic process (GO:0009145)3.27689297
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25514470
47nucleotide transmembrane transport (GO:1901679)3.25044568
48purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.24708595
49regulation of cellular amino acid metabolic process (GO:0006521)3.22364071
50deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.22075272
51regulation of timing of cell differentiation (GO:0048505)3.21970059
52ribosomal small subunit assembly (GO:0000028)3.20211439
53mesenchymal cell differentiation involved in kidney development (GO:0072161)3.19580402
54mesenchymal cell differentiation involved in renal system development (GO:2001012)3.19580402
55protein deneddylation (GO:0000338)3.19078265
56SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18175556
57postsynaptic membrane organization (GO:0001941)3.17516454
58cotranslational protein targeting to membrane (GO:0006613)3.17245540
59GPI anchor metabolic process (GO:0006505)3.16508674
60centriole assembly (GO:0098534)3.16403799
61hydrogen ion transmembrane transport (GO:1902600)3.13084317
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12399667
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.11339973
64protein targeting to ER (GO:0045047)3.11061344
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.09966144
66maturation of SSU-rRNA (GO:0030490)3.08055003
67protein targeting to mitochondrion (GO:0006626)3.07479785
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06745748
69negative regulation of ligase activity (GO:0051352)3.06745748
70fatty acid elongation (GO:0030497)3.05680804
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05265394
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05265394
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05265394
74purine nucleobase biosynthetic process (GO:0009113)3.04931170
75protein-cofactor linkage (GO:0018065)3.04169443
76histone mRNA metabolic process (GO:0008334)3.03708911
77epithelial cilium movement (GO:0003351)3.03658204
78telomere maintenance via recombination (GO:0000722)3.02887045
79response to redox state (GO:0051775)3.02804920
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02463591
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02463591
82translation (GO:0006412)3.01741244
83DNA strand elongation involved in DNA replication (GO:0006271)3.01665345
84deoxyribose phosphate biosynthetic process (GO:0046385)3.00982213
852-deoxyribonucleotide biosynthetic process (GO:0009265)3.00982213
86DNA catabolic process, exonucleolytic (GO:0000738)3.00420385
87translational termination (GO:0006415)3.00369399
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99002772
89establishment of protein localization to endoplasmic reticulum (GO:0072599)2.98112247
90maturation of 5.8S rRNA (GO:0000460)2.97863944
91dendritic cell chemotaxis (GO:0002407)2.97571711
92protein localization to endoplasmic reticulum (GO:0070972)2.97033109
93cerebral cortex radially oriented cell migration (GO:0021799)2.96532344
94negative regulation of myoblast differentiation (GO:0045662)2.96434104
95viral transcription (GO:0019083)2.96385826
96ribosomal large subunit biogenesis (GO:0042273)2.95574392
97recombinational repair (GO:0000725)2.94756978
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94529803
99DNA replication-independent nucleosome assembly (GO:0006336)2.94362463
100DNA replication-independent nucleosome organization (GO:0034724)2.94362463
101adenosine metabolic process (GO:0046085)2.93908070
102inner mitochondrial membrane organization (GO:0007007)2.93807191
103keratinocyte development (GO:0003334)2.93752719
104DNA replication-dependent nucleosome assembly (GO:0006335)2.93268626
105DNA replication-dependent nucleosome organization (GO:0034723)2.93268626
106GTP biosynthetic process (GO:0006183)2.92393228
107double-strand break repair via homologous recombination (GO:0000724)2.92254792
108pseudouridine synthesis (GO:0001522)2.91744731
109signal transduction involved in DNA damage checkpoint (GO:0072422)2.90264148
110signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90264148
111positive regulation of action potential (GO:0045760)2.89968986
112DNA strand elongation (GO:0022616)2.89154242
113signal transduction involved in cell cycle checkpoint (GO:0072395)2.89096979
114proton transport (GO:0015992)2.89014753
115protein localization to mitochondrion (GO:0070585)2.88472230
116mitotic recombination (GO:0006312)2.88269338
117establishment of protein localization to mitochondrion (GO:0072655)2.88056919
118ribonucleoside triphosphate biosynthetic process (GO:0009201)2.87851083
119inner ear receptor stereocilium organization (GO:0060122)2.87090769
120replication fork processing (GO:0031297)2.86734619
121protein heterotetramerization (GO:0051290)2.86399375
122startle response (GO:0001964)2.82462988
123DNA integration (GO:0015074)2.78661777
124regulation of collateral sprouting (GO:0048670)2.74967944
125regulation of development, heterochronic (GO:0040034)2.74191260
126detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74158171
127developmental pigmentation (GO:0048066)2.73688786
128isoprenoid biosynthetic process (GO:0008299)2.73016871
129photoreceptor cell maintenance (GO:0045494)2.70692418
130mannosylation (GO:0097502)2.70059779
131histone H2B ubiquitination (GO:0033523)2.68270830
132cell proliferation in forebrain (GO:0021846)2.66219201
133centriole replication (GO:0007099)2.65783207
134negative regulation of execution phase of apoptosis (GO:1900118)2.65736206
135righting reflex (GO:0060013)2.63510241
136regulation of memory T cell differentiation (GO:0043380)2.61606574
137lymphoid progenitor cell differentiation (GO:0002320)2.61244878
138protein neddylation (GO:0045116)2.58841133
139nonmotile primary cilium assembly (GO:0035058)2.57988397
140dendritic cell migration (GO:0036336)2.57875227
141female gonad development (GO:0008585)2.56159237
142C-terminal protein lipidation (GO:0006501)2.55420458
143regulation of pigment cell differentiation (GO:0050932)2.54535647
144positive regulation of protein homodimerization activity (GO:0090073)2.54500539
145auditory receptor cell stereocilium organization (GO:0060088)2.51004417
146sympathetic nervous system development (GO:0048485)2.49927256
147energy homeostasis (GO:0097009)2.47581985
148G-protein coupled receptor internalization (GO:0002031)2.46982791
149mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.44721481
150cranial nerve development (GO:0021545)2.44000906
151androgen biosynthetic process (GO:0006702)2.42047015
152myelination (GO:0042552)2.40837443
153positive regulation of cell fate commitment (GO:0010455)2.40231098
154neuron cell-cell adhesion (GO:0007158)2.39301464
155regulation of activation of Janus kinase activity (GO:0010533)2.39240183
156mesonephros development (GO:0001823)2.39079991
157regulation of dendritic cell antigen processing and presentation (GO:0002604)2.38879564
158nucleoside diphosphate catabolic process (GO:0009134)2.38701296
159tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37140457
160RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37140457
161facial nerve structural organization (GO:0021612)2.37056258
162eye photoreceptor cell differentiation (GO:0001754)2.36277240
163photoreceptor cell differentiation (GO:0046530)2.36277240
164DNA strand renaturation (GO:0000733)2.36126510
165negative regulation of protein localization to cell surface (GO:2000009)2.35703645
166positive regulation of uterine smooth muscle contraction (GO:0070474)2.35367459
167oligodendrocyte differentiation (GO:0048709)2.35291357
168intraciliary transport (GO:0042073)2.34184067
169mesenchymal cell differentiation (GO:0048762)2.33191701
170axon ensheathment (GO:0008366)2.31200113
171ensheathment of neurons (GO:0007272)2.31200113
172sphingoid metabolic process (GO:0046519)2.30507891
173positive regulation of interleukin-17 production (GO:0032740)2.29540579
174glycolipid biosynthetic process (GO:0009247)2.28680834
175C-terminal protein amino acid modification (GO:0018410)2.27828779
176cranial nerve structural organization (GO:0021604)2.27281802
177glycerophospholipid catabolic process (GO:0046475)2.26435863
178cell differentiation involved in metanephros development (GO:0072202)2.25939558
179cranial nerve morphogenesis (GO:0021602)2.25713339
180negative regulation of axon guidance (GO:1902668)2.25128440
181protein prenylation (GO:0018342)2.24145113
182prenylation (GO:0097354)2.24145113
183estrogen biosynthetic process (GO:0006703)2.23279785
184axonemal dynein complex assembly (GO:0070286)2.22389189
185inner ear receptor cell differentiation (GO:0060113)2.20461634
186neuron remodeling (GO:0016322)2.19733433
187negative regulation of keratinocyte proliferation (GO:0010839)2.19522253
188positive regulation of interleukin-1 beta secretion (GO:0050718)2.18033288
189lateral sprouting from an epithelium (GO:0060601)2.17981464
190detection of light stimulus involved in visual perception (GO:0050908)2.17716935
191detection of light stimulus involved in sensory perception (GO:0050962)2.17716935
192regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.17338018
193reflex (GO:0060004)2.16808861
194negative regulation of neurotransmitter transport (GO:0051589)2.16436609
195regulation of non-canonical Wnt signaling pathway (GO:2000050)2.15798345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.02946020
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.42970857
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.02714831
4GBX2_23144817_ChIP-Seq_PC3_Human3.83013371
5E2F7_22180533_ChIP-Seq_HELA_Human3.82633184
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20696350
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.16793079
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03838209
9ZFP57_27257070_Chip-Seq_ESCs_Mouse3.02635101
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.91874908
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.91235078
12ELK1_19687146_ChIP-ChIP_HELA_Human2.90643758
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79243639
14VDR_23849224_ChIP-Seq_CD4+_Human2.78173070
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.71964506
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63347863
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.62383101
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61984079
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.59183700
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50620303
21VDR_22108803_ChIP-Seq_LS180_Human2.44052746
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.40179678
23EZH2_22144423_ChIP-Seq_EOC_Human2.39765909
24FOXP3_21729870_ChIP-Seq_TREG_Human2.37499160
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37181169
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36530306
27SUZ12_27294783_Chip-Seq_NPCs_Mouse2.28702639
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.26781655
29PCGF2_27294783_Chip-Seq_NPCs_Mouse2.25800501
30ZNF274_21170338_ChIP-Seq_K562_Hela2.20696211
31CBX2_27304074_Chip-Seq_ESCs_Mouse2.18199358
32NFE2_27457419_Chip-Seq_LIVER_Mouse2.13492540
33POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05667205
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02300824
35TAF15_26573619_Chip-Seq_HEK293_Human1.99851366
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99544716
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.95708502
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.94492243
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94469078
40MYC_18940864_ChIP-ChIP_HL60_Human1.93535877
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.93064728
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92018955
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91276739
44SUZ12_18555785_Chip-Seq_ESCs_Mouse1.90598028
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.89625101
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89540067
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89389169
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.87821235
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87369373
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87228535
51DCP1A_22483619_ChIP-Seq_HELA_Human1.87188937
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86563537
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.85616881
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85437164
55STAT3_18555785_Chip-Seq_ESCs_Mouse1.84873682
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83685328
57P53_22387025_ChIP-Seq_ESCs_Mouse1.81932343
58P300_19829295_ChIP-Seq_ESCs_Human1.81603349
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79440615
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.79332822
61EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.77749416
62CMYC_18555785_Chip-Seq_ESCs_Mouse1.76002899
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74732497
64P300_18555785_Chip-Seq_ESCs_Mouse1.74071115
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70414835
66RNF2_27304074_Chip-Seq_NSC_Mouse1.70372776
67NMYC_18555785_Chip-Seq_ESCs_Mouse1.70294981
68RUNX1_27457419_Chip-Seq_LIVER_Mouse1.65888830
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65567844
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65101359
71ER_23166858_ChIP-Seq_MCF-7_Human1.64119301
72FUS_26573619_Chip-Seq_HEK293_Human1.63973379
73* GABP_19822575_ChIP-Seq_HepG2_Human1.63637035
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62852189
75TTF2_22483619_ChIP-Seq_HELA_Human1.62583780
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60248156
77SOX2_18555785_Chip-Seq_ESCs_Mouse1.57621232
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57524592
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.56449328
80KLF4_18555785_Chip-Seq_ESCs_Mouse1.56196451
81IGF1R_20145208_ChIP-Seq_DFB_Human1.55253150
82ZFX_18555785_Chip-Seq_ESCs_Mouse1.55058943
83OCT4_18555785_Chip-Seq_ESCs_Mouse1.54805923
84SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54412055
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54163290
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53213562
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52396304
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51829882
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51817403
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.51503464
91PU1_27457419_Chip-Seq_LIVER_Mouse1.49106457
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48771097
93BP1_19119308_ChIP-ChIP_Hs578T_Human1.48484549
94SMAD1_18555785_Chip-Seq_ESCs_Mouse1.47118591
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44315076
96ESRRB_18555785_Chip-Seq_ESCs_Mouse1.44158137
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43746504
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.42836630
99POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40769080
100CTCF_18555785_Chip-Seq_ESCs_Mouse1.40396824
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38980622
102EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38980622
103EZH2_27294783_Chip-Seq_ESCs_Mouse1.38758372
104TP53_22573176_ChIP-Seq_HFKS_Human1.37285843
105EWS_26573619_Chip-Seq_HEK293_Human1.36914357
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.36802720
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36199653
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35847015
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35273181
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.31887487
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30155340
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29963853
113SMAD4_21799915_ChIP-Seq_A2780_Human1.29860009
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29076367
115FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28930309
116* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28604631
117RNF2_27304074_Chip-Seq_ESCs_Mouse1.28017948
118CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27739320
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27488085
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26686168
121IRF1_19129219_ChIP-ChIP_H3396_Human1.25420860
122OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25199784
123MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24518429
124NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23501363
125E2F1_21310950_ChIP-Seq_MCF-7_Human1.23022396
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22344932
127XRN2_22483619_ChIP-Seq_HELA_Human1.21788354
128TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21439130
129* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21318156
130SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21148527
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.20289347
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20092095
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18894186
134LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18386836
135ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16793563
136E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15815581
137TP53_18474530_ChIP-ChIP_U2OS_Human1.14377282
138YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14188639
139SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14050097
140FOXA1_25329375_ChIP-Seq_VCAP_Human1.13879495
141FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13879495
142MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10759288
143ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10375802
144KDM2B_26808549_Chip-Seq_REH_Human1.09156741
145AR_21572438_ChIP-Seq_LNCaP_Human1.08861669
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07867908
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07827577
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07827577
149YY1_21170310_ChIP-Seq_MESCs_Mouse1.07370857
150MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07326502
151AR_20517297_ChIP-Seq_VCAP_Human1.07284269
152ELK1_22589737_ChIP-Seq_MCF10A_Human1.06206505
153VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06126039
154RUNX2_22187159_ChIP-Seq_PCA_Human1.04694661
155SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03101527
156KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99833001
157SALL1_21062744_ChIP-ChIP_HESCs_Human0.98972718
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98717676
159CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98547441
160KDM5A_27292631_Chip-Seq_BREAST_Human0.98293566
161SOX2_19829295_ChIP-Seq_ESCs_Human0.98020934
162NANOG_19829295_ChIP-Seq_ESCs_Human0.98020934
163HTT_18923047_ChIP-ChIP_STHdh_Human0.94279831
164FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94270334
165PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92060074
166CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91278642
167* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91118654
168MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90704294
169NOTCH1_21737748_ChIP-Seq_TLL_Human0.89017748
170AR_21909140_ChIP-Seq_LNCAP_Human0.87114328
171* RBPJ_21746931_ChIP-Seq_IB4_Human0.87015928
172NCOR_22424771_ChIP-Seq_293T_Human0.85843069
173FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85667328
174ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83389879
175RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83027754
176* ERG_20517297_ChIP-Seq_VCAP_Human0.81903145
177* PHF8_20622853_ChIP-Seq_HELA_Human0.81824340
178IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80940057
179CBP_20019798_ChIP-Seq_JUKART_Human0.80940057

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.81302073
2MP0001188_hyperpigmentation3.63635822
3MP0000566_synostosis3.20484917
4MP0003806_abnormal_nucleotide_metabolis3.18744123
5MP0006292_abnormal_olfactory_placode3.05660887
6MP0010094_abnormal_chromosome_stability3.02749139
7MP0008877_abnormal_DNA_methylation2.94380257
8MP0005409_darkened_coat_color2.75781670
9MP0004381_abnormal_hair_follicle2.70243683
10MP0004742_abnormal_vestibular_system2.67887811
11MP0005171_absent_coat_pigmentation2.55403255
12MP0002277_abnormal_respiratory_mucosa2.34309187
13MP0002102_abnormal_ear_morphology2.33837237
14MP0001986_abnormal_taste_sensitivity2.31391966
15MP0003786_premature_aging2.30148226
16MP0008057_abnormal_DNA_replication2.27815866
17MP0006036_abnormal_mitochondrial_physio2.25215599
18MP0003186_abnormal_redox_activity2.18284643
19MP0005451_abnormal_body_composition2.17000639
20MP0005645_abnormal_hypothalamus_physiol2.09363905
21MP0005084_abnormal_gallbladder_morpholo2.05948088
22MP0003693_abnormal_embryo_hatching2.05554877
23MP0000015_abnormal_ear_pigmentation1.99125272
24MP0003195_calcinosis1.96650534
25MP0004957_abnormal_blastocyst_morpholog1.91186327
26MP0008875_abnormal_xenobiotic_pharmacok1.83220585
27MP0000383_abnormal_hair_follicle1.81633844
28MP0003880_abnormal_central_pattern1.81581642
29MP0005174_abnormal_tail_pigmentation1.80871229
30MP0009379_abnormal_foot_pigmentation1.80718364
31MP0001346_abnormal_lacrimal_gland1.80551219
32MP0002837_dystrophic_cardiac_calcinosis1.73822671
33MP0005646_abnormal_pituitary_gland1.72523984
34MP0008007_abnormal_cellular_replicative1.70359123
35MP0001486_abnormal_startle_reflex1.69819423
36MP0001529_abnormal_vocalization1.65779863
37MP0009697_abnormal_copulation1.64672336
38MP0005379_endocrine/exocrine_gland_phen1.63984895
39MP0001905_abnormal_dopamine_level1.58974137
40MP0003077_abnormal_cell_cycle1.57387515
41MP0000920_abnormal_myelination1.57373961
42MP0002876_abnormal_thyroid_physiology1.56484143
43MP0003111_abnormal_nucleus_morphology1.55978207
44MP0004142_abnormal_muscle_tone1.55819394
45MP0008260_abnormal_autophagy1.53021258
46MP0005389_reproductive_system_phenotype1.51890209
47MP0002160_abnormal_reproductive_system1.50980811
48MP0000026_abnormal_inner_ear1.50570280
49MP0001984_abnormal_olfaction1.49736909
50MP0002163_abnormal_gland_morphology1.48137433
51MP0000372_irregular_coat_pigmentation1.48070673
52MP0002735_abnormal_chemical_nociception1.44969505
53MP0005408_hypopigmentation1.44881537
54MP0006035_abnormal_mitochondrial_morpho1.44020605
55MP0002132_abnormal_respiratory_system1.42567269
56MP0002938_white_spotting1.42347784
57MP0008872_abnormal_physiological_respon1.42157602
58MP0010386_abnormal_urinary_bladder1.40932654
59MP0005551_abnormal_eye_electrophysiolog1.39930690
60MP0006072_abnormal_retinal_apoptosis1.38840789
61MP0002638_abnormal_pupillary_reflex1.37108074
62MP0001764_abnormal_homeostasis1.36600977
63MP0008932_abnormal_embryonic_tissue1.32325825
64MP0001963_abnormal_hearing_physiology1.32321146
65MP0001929_abnormal_gametogenesis1.30608701
66MP0002210_abnormal_sex_determination1.30255530
67MP0008058_abnormal_DNA_repair1.30218718
68MP0001919_abnormal_reproductive_system1.28097176
69MP0006276_abnormal_autonomic_nervous1.24674254
70MP0002095_abnormal_skin_pigmentation1.24608930
71MP0002148_abnormal_hypersensitivity_rea1.18295298
72MP0000516_abnormal_urinary_system1.16778200
73MP0005367_renal/urinary_system_phenotyp1.16778200
74MP0001485_abnormal_pinna_reflex1.15363183
75MP0000778_abnormal_nervous_system1.13690121
76MP0003121_genomic_imprinting1.12850102
77MP0002736_abnormal_nociception_after1.12696560
78MP0003941_abnormal_skin_development1.12648029
79MP0002272_abnormal_nervous_system1.12216373
80MP0000653_abnormal_sex_gland1.11878059
81MP0000049_abnormal_middle_ear1.11381869
82MP0001293_anophthalmia1.05841872
83MP0005253_abnormal_eye_physiology1.05250999
84MP0001145_abnormal_male_reproductive1.04523665
85MP0005423_abnormal_somatic_nervous1.04335114
86MP0003950_abnormal_plasma_membrane1.04162047
87MP0001790_abnormal_immune_system1.03723322
88MP0005387_immune_system_phenotype1.03723322
89MP0005075_abnormal_melanosome_morpholog1.03092183
90MP0005671_abnormal_response_to1.02995561
91MP0008995_early_reproductive_senescence1.02512452
92MP0002234_abnormal_pharynx_morphology1.02266495
93MP0004134_abnormal_chest_morphology1.01180030
94MP0002752_abnormal_somatic_nervous0.99985459
95MP0005332_abnormal_amino_acid0.98911204
96MP0000579_abnormal_nail_morphology0.96931239
97MP0001119_abnormal_female_reproductive0.96926578
98MP0001968_abnormal_touch/_nociception0.96366932
99MP0002177_abnormal_outer_ear0.96295326
100MP0005636_abnormal_mineral_homeostasis0.95485645
101MP0000631_abnormal_neuroendocrine_gland0.94962256
102MP0005410_abnormal_fertilization0.94569150
103MP0003938_abnormal_ear_development0.94481897
104MP0002751_abnormal_autonomic_nervous0.94384110
105MP0000762_abnormal_tongue_morphology0.94252659
106MP0009250_abnormal_appendicular_skeleto0.94145190
107MP0003698_abnormal_male_reproductive0.93583750
108MP0000647_abnormal_sebaceous_gland0.92023893
109MP0000358_abnormal_cell_content/0.91658087
110MP0005670_abnormal_white_adipose0.89479657
111MP0004043_abnormal_pH_regulation0.88520071
112MP0003787_abnormal_imprinting0.87322784
113MP0001502_abnormal_circadian_rhythm0.87280704
114MP0002067_abnormal_sensory_capabilities0.87006705
115MP0003724_increased_susceptibility_to0.85555552
116MP0008789_abnormal_olfactory_epithelium0.85399098
117MP0003252_abnormal_bile_duct0.84628520
118MP0000462_abnormal_digestive_system0.84436700
119MP0005266_abnormal_metabolism0.83681920
120MP0009745_abnormal_behavioral_response0.82602580
121MP0000613_abnormal_salivary_gland0.82464209
122MP0002653_abnormal_ependyma_morphology0.82307269
123MP0001835_abnormal_antigen_presentation0.81432172
124MP0005395_other_phenotype0.80971409
125MP0002734_abnormal_mechanical_nocicepti0.80533421
126MP0009046_muscle_twitch0.80014189
127MP0005310_abnormal_salivary_gland0.79979734
128MP0002184_abnormal_innervation0.79118424
129MP0004147_increased_porphyrin_level0.78624907
130MP0002928_abnormal_bile_duct0.77750112
131MP0001501_abnormal_sleep_pattern0.76868950
132MP0002249_abnormal_larynx_morphology0.75973060
133MP0002572_abnormal_emotion/affect_behav0.75968707
134MP0002557_abnormal_social/conspecific_i0.75545251
135MP0003567_abnormal_fetal_cardiomyocyte0.75127118
136MP0010678_abnormal_skin_adnexa0.73484244
137MP0002233_abnormal_nose_morphology0.73408222
138MP0002090_abnormal_vision0.73198144
139MP0003011_delayed_dark_adaptation0.73091177
140MP0000427_abnormal_hair_cycle0.72776136
141MP0001324_abnormal_eye_pigmentation0.72561884
142MP0002933_joint_inflammation0.72437359
143MP0004145_abnormal_muscle_electrophysio0.71350044
144MP0003937_abnormal_limbs/digits/tail_de0.70194410
145MP0003718_maternal_effect0.69851878
146MP0002282_abnormal_trachea_morphology0.68351791
147MP0001970_abnormal_pain_threshold0.67618332
148MP0005499_abnormal_olfactory_system0.67053024
149MP0005394_taste/olfaction_phenotype0.67053024
150MP0005195_abnormal_posterior_eye0.66787433
151MP0002098_abnormal_vibrissa_morphology0.66659473

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)4.60833536
2Mitochondrial inheritance (HP:0001427)4.57638256
3Acute encephalopathy (HP:0006846)4.54975120
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.48584325
5Progressive macrocephaly (HP:0004481)4.37765935
6Increased CSF lactate (HP:0002490)4.25620789
7Hepatocellular necrosis (HP:0001404)3.92484110
8Chromsome breakage (HP:0040012)3.91829599
9Hepatic necrosis (HP:0002605)3.77269732
10Septo-optic dysplasia (HP:0100842)3.75280511
11Increased hepatocellular lipid droplets (HP:0006565)3.71004439
12Parakeratosis (HP:0001036)3.59453581
13Lipid accumulation in hepatocytes (HP:0006561)3.50067378
14Pancreatic cysts (HP:0001737)3.47395143
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.45725341
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.45725341
17Cerebral edema (HP:0002181)3.39517537
18Duplicated collecting system (HP:0000081)3.34130940
19Molar tooth sign on MRI (HP:0002419)3.22137252
20Abnormality of midbrain morphology (HP:0002418)3.22137252
21Abnormality of the renal collecting system (HP:0004742)3.15574339
22Upper limb muscle weakness (HP:0003484)3.10433650
23Patchy hypopigmentation of hair (HP:0011365)3.06863853
24White forelock (HP:0002211)3.04514887
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.93350646
26Hypothermia (HP:0002045)2.85836418
27Absent septum pellucidum (HP:0001331)2.84169515
28Dynein arm defect of respiratory motile cilia (HP:0012255)2.77879145
29Absent/shortened dynein arms (HP:0200106)2.77879145
30Lactic acidosis (HP:0003128)2.77312637
31Increased serum lactate (HP:0002151)2.77208880
32Febrile seizures (HP:0002373)2.74962766
33Congenital sensorineural hearing impairment (HP:0008527)2.74245346
34Increased intramyocellular lipid droplets (HP:0012240)2.73321477
35Exertional dyspnea (HP:0002875)2.72259128
36Prostate neoplasm (HP:0100787)2.71062079
37Abnormal ciliary motility (HP:0012262)2.68557986
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.66435099
39Respiratory failure (HP:0002878)2.65914241
403-Methylglutaconic aciduria (HP:0003535)2.60776072
41Abnormality of incisor morphology (HP:0011063)2.59191445
42Rhinitis (HP:0012384)2.59118882
43Congenital stationary night blindness (HP:0007642)2.58955824
44Optic disc pallor (HP:0000543)2.57921077
45Abnormality of the septum pellucidum (HP:0007375)2.57209284
46Aplasia cutis congenita (HP:0001057)2.51055436
47Medial flaring of the eyebrow (HP:0010747)2.50032034
48Duplication of thumb phalanx (HP:0009942)2.49173399
49Decreased central vision (HP:0007663)2.49103195
50Optic nerve hypoplasia (HP:0000609)2.47799177
51Abnormal respiratory motile cilium morphology (HP:0005938)2.43011367
52Abnormal respiratory epithelium morphology (HP:0012253)2.43011367
53Methylmalonic acidemia (HP:0002912)2.42606684
54Congenital, generalized hypertrichosis (HP:0004540)2.40249488
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39387754
56Abnormality of alanine metabolism (HP:0010916)2.39387754
57Hyperalaninemia (HP:0003348)2.39387754
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35949551
59Microvesicular hepatic steatosis (HP:0001414)2.35158903
60Abnormal respiratory motile cilium physiology (HP:0012261)2.31488888
61Exercise intolerance (HP:0003546)2.31031335
62Sclerocornea (HP:0000647)2.30506683
63Adrenal hypoplasia (HP:0000835)2.25833276
64Reticulocytopenia (HP:0001896)2.24071002
65Increased muscle lipid content (HP:0009058)2.23321157
66Lethargy (HP:0001254)2.22650491
67Leukodystrophy (HP:0002415)2.20073753
68Tubulointerstitial nephritis (HP:0001970)2.17600754
69Optic neuritis (HP:0100653)2.15764240
70Retrobulbar optic neuritis (HP:0100654)2.15764240
71Abnormal number of erythroid precursors (HP:0012131)2.14148160
72Methylmalonic aciduria (HP:0012120)2.13134135
73Abnormality of chromosome stability (HP:0003220)2.12963045
74Macrocytic anemia (HP:0001972)2.12717851
75Aplasia/Hypoplasia of the tongue (HP:0010295)2.11555899
76Prolonged neonatal jaundice (HP:0006579)2.11312646
77Xerostomia (HP:0000217)2.10884983
78Abnormality of cells of the erythroid lineage (HP:0012130)2.09764194
79Aplasia/Hypoplasia of the uvula (HP:0010293)2.07431222
80Anomalous pulmonary venous return (HP:0010772)2.07203214
81Male pseudohermaphroditism (HP:0000037)2.05375251
82Aplasia/Hypoplasia of the fovea (HP:0008060)2.05323504
83Hypoplasia of the fovea (HP:0007750)2.05323504
84Abnormality of the axillary hair (HP:0100134)2.04526672
85Abnormality of secondary sexual hair (HP:0009888)2.04526672
86Genital tract atresia (HP:0001827)2.04147015
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03475188
88Abnormality of the renal cortex (HP:0011035)2.03285943
89Abnormal protein glycosylation (HP:0012346)2.02583206
90Abnormal glycosylation (HP:0012345)2.02583206
91Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02583206
92Abnormal protein N-linked glycosylation (HP:0012347)2.02583206
93True hermaphroditism (HP:0010459)2.02115205
94Absent thumb (HP:0009777)2.01685231
95Abnormality of the preputium (HP:0100587)2.01322709
96Asplenia (HP:0001746)2.01176035
97Nasolacrimal duct obstruction (HP:0000579)2.00989913
98Abnormality of urine glucose concentration (HP:0011016)2.00585721
99Glycosuria (HP:0003076)2.00585721
100Aplastic anemia (HP:0001915)1.99177166
101Chronic bronchitis (HP:0004469)1.98984301
102Nephrogenic diabetes insipidus (HP:0009806)1.98864778
103Vaginal atresia (HP:0000148)1.98712457
104Pancytopenia (HP:0001876)1.98164540
105Cystic liver disease (HP:0006706)1.96714813
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96550509
107Congenital primary aphakia (HP:0007707)1.96502967
108Generalized aminoaciduria (HP:0002909)1.96296499
109Anencephaly (HP:0002323)1.95658398
110CNS demyelination (HP:0007305)1.95142271
111Nephronophthisis (HP:0000090)1.94848442
112Keratoconus (HP:0000563)1.94752973
113Increased corneal curvature (HP:0100692)1.94752973
114Renal Fanconi syndrome (HP:0001994)1.93306104
115Conical tooth (HP:0000698)1.92780950
116Abnormal hair whorl (HP:0010721)1.92590934
117Respiratory difficulties (HP:0002880)1.92045742
118Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91701829
119Gait imbalance (HP:0002141)1.91683909
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.91648100
121Abnormality of DNA repair (HP:0003254)1.91373102
122Renal cortical cysts (HP:0000803)1.88153101
123Median cleft lip (HP:0000161)1.85803964
124Meckel diverticulum (HP:0002245)1.85513047
125Abnormality of the pulmonary veins (HP:0011718)1.85486793
126Submucous cleft hard palate (HP:0000176)1.85263629
127Aplasia/Hypoplasia of the spleen (HP:0010451)1.85075673
128Abnormality of the anterior horn cell (HP:0006802)1.85046157
129Degeneration of anterior horn cells (HP:0002398)1.85046157
130Aplasia/hypoplasia of the uterus (HP:0008684)1.84951621
131Abnormality of the ileum (HP:0001549)1.84199704
132Pancreatic fibrosis (HP:0100732)1.83260655
133Bronchiectasis (HP:0002110)1.82176716
134Triphalangeal thumb (HP:0001199)1.82018382
135Abnormality of the renal medulla (HP:0100957)1.81683749
136Hyperglycinemia (HP:0002154)1.80710466
137Colon cancer (HP:0003003)1.80201876
138Acute necrotizing encephalopathy (HP:0006965)1.80103576
139Preaxial hand polydactyly (HP:0001177)1.79716659
140Renal agenesis (HP:0000104)1.77814317
141Furrowed tongue (HP:0000221)1.77049594
142Severe combined immunodeficiency (HP:0004430)1.75307404
143Recurrent pneumonia (HP:0006532)1.74856366
144Congenital ichthyosiform erythroderma (HP:0007431)1.73521097
145Clubbing of toes (HP:0100760)1.72324859
146Abnormality of the labia minora (HP:0012880)1.72161444
147Small intestinal stenosis (HP:0012848)1.71696939
148Duodenal stenosis (HP:0100867)1.71696939
149Attenuation of retinal blood vessels (HP:0007843)1.71422691
150Short tibia (HP:0005736)1.71418434
151Aplasia/Hypoplasia of the lens (HP:0008063)1.70415848
152Congenital hepatic fibrosis (HP:0002612)1.70207838
153Abnormality of the lacrimal duct (HP:0011481)1.69666262
154Chronic hepatic failure (HP:0100626)1.69653751
155Cupped ear (HP:0000378)1.69639953
156Abnormality of the nasal septum (HP:0000419)1.69281731
157Sensory axonal neuropathy (HP:0003390)1.69123957
158Type I transferrin isoform profile (HP:0003642)1.68959955
159Abnormality of the fovea (HP:0000493)1.67938403
160Astigmatism (HP:0000483)1.67769230
161Hypergonadotropic hypogonadism (HP:0000815)1.66136525
162Postaxial foot polydactyly (HP:0001830)1.65556490
163Double outlet right ventricle (HP:0001719)1.65135104
164Congenital malformation of the right heart (HP:0011723)1.65135104
165Lip pit (HP:0100267)1.65072908
166Abnormal rod and cone electroretinograms (HP:0008323)1.64689929
167Partial duplication of thumb phalanx (HP:0009944)1.64195514
168Abnormality of renal resorption (HP:0011038)1.63652262
169Abnormality of the nasolacrimal system (HP:0000614)1.62826047
170Abnormality of the columella (HP:0009929)1.62056059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.50460158
2VRK22.91262351
3STK162.67156900
4TNIK2.64776817
5BUB12.59308317
6CDC72.54800419
7EIF2AK12.30368191
8FRK2.30312610
9TXK2.22393645
10ZAK2.20046239
11IRAK42.19359589
12TRIM282.15971910
13NEK12.14505250
14BCR2.09212329
15GRK12.04814423
16EIF2AK22.01030009
17BMPR21.99913110
18INSRR1.98677753
19MAP3K141.96953828
20ADRBK21.94370840
21WEE11.91818165
22STK391.88051838
23BCKDK1.81897363
24MAP3K121.80996991
25PBK1.79420077
26PKN11.71611323
27MAP4K21.71322116
28YES11.70426240
29NEK61.70102627
30MST41.68941431
31IRAK31.64236862
32WNK31.62035846
33MUSK1.60864176
34PDK21.56228930
35MKNK21.50740423
36OXSR11.49034977
37IRAK11.48936808
38GRK71.46387102
39PLK31.46000745
40MKNK11.39856215
41ACVR1B1.37186628
42CLK11.35124707
43TTK1.30946662
44SIK31.29114239
45BMPR1B1.29086764
46PRPF4B1.28309037
47BRSK21.27496533
48MAPK131.27372181
49MAPKAPK51.23270760
50CDK31.22205493
51PLK11.21093791
52IRAK21.19048602
53SRPK11.19021069
54VRK11.17031481
55CSNK1G21.16319785
56CCNB11.13718191
57MAP3K41.11696831
58MAP2K71.11405543
59ATR1.03641059
60KDR1.03226006
61IKBKB1.02181566
62NUAK10.97272091
63DYRK20.97248241
64PRKCE0.94743301
65MAPK150.94546592
66BLK0.92703560
67TRPM70.92054454
68NTRK30.88153949
69MAP3K130.87127450
70IKBKE0.86604771
71CHEK20.85785878
72TEC0.84178789
73TLK10.83852618
74CAMK2B0.82973273
75TNK20.82829374
76SCYL20.82337665
77NLK0.80944666
78AURKB0.80505401
79PLK20.80194037
80STK38L0.76360227
81PIK3CG0.76342131
82FLT30.75395634
83PLK40.74920919
84ERBB30.74025511
85DAPK10.72378871
86CAMK2D0.71892191
87TAOK30.71693649
88EPHB20.70892016
89EPHA30.68630494
90NME10.68430070
91CSNK1A1L0.68116151
92RPS6KA50.66555481
93PASK0.66467424
94LIMK10.64871363
95CAMK2A0.64111998
96CSNK2A10.63818862
97AURKA0.62803971
98SGK4940.60762601
99SGK2230.60762601
100AKT30.58776705
101CSNK2A20.58060064
102CDK80.57610050
103CSNK1G10.56791458
104CSNK1G30.56624441
105PRKCQ0.56279158
106ATM0.55899281
107MYLK0.55862820
108TAF10.54663242
109PRKG10.54457918
110MAPKAPK30.53367819
111CDK190.52382453
112PINK10.52017504
113CAMK2G0.51733050
114MAPK70.50434367
115PRKD20.50333003
116PIK3CA0.49373580
117BRSK10.49106600
118OBSCN0.47876207
119PRKCI0.47352266
120ABL20.47309142
121LYN0.46478782
122EPHB10.46319690
123ILK0.46015898
124PNCK0.45340735
125PRKCG0.45334039
126NEK20.45040228
127PIM20.44828319
128KIT0.44764902
129TGFBR10.43868271
130UHMK10.43276557
131CAMKK20.42678285
132LCK0.41170934
133WNK40.40982980
134SGK20.40356092
135PRKACA0.40129671
136CHUK0.39699830
137DYRK30.39085248
138DYRK1A0.38672914
139PAK30.37875326
140RPS6KA40.37219638
141ROCK20.36502713
142CSNK1A10.36332557
143MINK10.36322422
144PRKCD0.34585116
145BRD40.34229995
146NTRK20.33492282
147FGR0.30447351
148ERBB40.29774422
149EIF2AK30.29248318
150BTK0.28860444
151ADRBK10.28767484
152NME20.27821117

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034302.88956896
2DNA replication_Homo sapiens_hsa030302.83912575
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.73829570
4Protein export_Homo sapiens_hsa030602.51280943
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.36407429
6Oxidative phosphorylation_Homo sapiens_hsa001902.35594976
7Steroid biosynthesis_Homo sapiens_hsa001002.23541143
8Sphingolipid metabolism_Homo sapiens_hsa006002.10579276
9Ether lipid metabolism_Homo sapiens_hsa005652.07722383
10Fanconi anemia pathway_Homo sapiens_hsa034602.07317519
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03730777
12Fatty acid elongation_Homo sapiens_hsa000621.93145641
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88255771
14Phototransduction_Homo sapiens_hsa047441.84670603
15Non-homologous end-joining_Homo sapiens_hsa034501.83094995
16One carbon pool by folate_Homo sapiens_hsa006701.79057599
17Autoimmune thyroid disease_Homo sapiens_hsa053201.76785789
18Homologous recombination_Homo sapiens_hsa034401.73182934
19Arachidonic acid metabolism_Homo sapiens_hsa005901.72025200
20Graft-versus-host disease_Homo sapiens_hsa053321.71874720
21Nicotine addiction_Homo sapiens_hsa050331.65539668
22Linoleic acid metabolism_Homo sapiens_hsa005911.59077222
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58654287
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53710925
25Rheumatoid arthritis_Homo sapiens_hsa053231.53488491
26Parkinsons disease_Homo sapiens_hsa050121.52375085
27Spliceosome_Homo sapiens_hsa030401.49573784
28Propanoate metabolism_Homo sapiens_hsa006401.45239710
29Allograft rejection_Homo sapiens_hsa053301.42842820
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41652358
31Serotonergic synapse_Homo sapiens_hsa047261.41483479
32Basal transcription factors_Homo sapiens_hsa030221.40997270
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39426257
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39142419
35Collecting duct acid secretion_Homo sapiens_hsa049661.35319212
36Alzheimers disease_Homo sapiens_hsa050101.33531045
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32448102
38RNA polymerase_Homo sapiens_hsa030201.32101859
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.31922892
40RNA transport_Homo sapiens_hsa030131.29044198
41Huntingtons disease_Homo sapiens_hsa050161.22203692
42Asthma_Homo sapiens_hsa053101.21832300
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21689368
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20075250
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.18373566
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17810685
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16068385
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14966900
49Ribosome_Homo sapiens_hsa030101.14105157
50Taste transduction_Homo sapiens_hsa047421.12238694
51Hematopoietic cell lineage_Homo sapiens_hsa046401.11957838
52Glutathione metabolism_Homo sapiens_hsa004801.08783664
53Folate biosynthesis_Homo sapiens_hsa007901.07457093
54Morphine addiction_Homo sapiens_hsa050321.02689301
55Butanoate metabolism_Homo sapiens_hsa006501.01156271
56Primary immunodeficiency_Homo sapiens_hsa053401.00566657
57Peroxisome_Homo sapiens_hsa041461.00468940
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.98273682
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93720032
60Histidine metabolism_Homo sapiens_hsa003400.93095229
61Axon guidance_Homo sapiens_hsa043600.92776667
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92517281
63Nitrogen metabolism_Homo sapiens_hsa009100.92161752
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90879573
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90552307
66Pyruvate metabolism_Homo sapiens_hsa006200.90072618
67Ovarian steroidogenesis_Homo sapiens_hsa049130.88046632
68Caffeine metabolism_Homo sapiens_hsa002320.87523628
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87078356
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.86752097
71Proteasome_Homo sapiens_hsa030500.86416931
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85897862
73Cell cycle_Homo sapiens_hsa041100.83407893
74Chemical carcinogenesis_Homo sapiens_hsa052040.83194271
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82438552
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82433688
77Vitamin digestion and absorption_Homo sapiens_hsa049770.81481552
78Malaria_Homo sapiens_hsa051440.80385431
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77961405
80Glutamatergic synapse_Homo sapiens_hsa047240.76744982
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76400051
82Selenocompound metabolism_Homo sapiens_hsa004500.75497186
83Phagosome_Homo sapiens_hsa041450.73277455
84Purine metabolism_Homo sapiens_hsa002300.70476767
85Nucleotide excision repair_Homo sapiens_hsa034200.69021246
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.68707443
87Vibrio cholerae infection_Homo sapiens_hsa051100.64278574
88Retinol metabolism_Homo sapiens_hsa008300.62488747
89Tryptophan metabolism_Homo sapiens_hsa003800.62487585
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60892684
91Basal cell carcinoma_Homo sapiens_hsa052170.60592083
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.60460563
93Pyrimidine metabolism_Homo sapiens_hsa002400.59661038
94Measles_Homo sapiens_hsa051620.59427607
95Regulation of autophagy_Homo sapiens_hsa041400.58524902
96Calcium signaling pathway_Homo sapiens_hsa040200.56665343
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56302039
98Ras signaling pathway_Homo sapiens_hsa040140.55775882
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55184634
100p53 signaling pathway_Homo sapiens_hsa041150.54535515
101beta-Alanine metabolism_Homo sapiens_hsa004100.51400155
102Other glycan degradation_Homo sapiens_hsa005110.50847569
103Olfactory transduction_Homo sapiens_hsa047400.50680397
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50286352
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50192988
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.50122136
107Sulfur metabolism_Homo sapiens_hsa009200.49738424
108GABAergic synapse_Homo sapiens_hsa047270.47834845
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47347765
110African trypanosomiasis_Homo sapiens_hsa051430.46692199
111Hedgehog signaling pathway_Homo sapiens_hsa043400.45540913
112RNA degradation_Homo sapiens_hsa030180.44899826
113Oocyte meiosis_Homo sapiens_hsa041140.44698583
114Cocaine addiction_Homo sapiens_hsa050300.44496540
115Chemokine signaling pathway_Homo sapiens_hsa040620.44177368
116Metabolic pathways_Homo sapiens_hsa011000.43868505
117Fatty acid degradation_Homo sapiens_hsa000710.43784517
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.43603467
119Cardiac muscle contraction_Homo sapiens_hsa042600.43252979
120Systemic lupus erythematosus_Homo sapiens_hsa053220.42581281
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40157272
122Circadian entrainment_Homo sapiens_hsa047130.39781158
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39393096
124N-Glycan biosynthesis_Homo sapiens_hsa005100.37806325
125Arginine and proline metabolism_Homo sapiens_hsa003300.37152648
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35789114
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35598596
128Mineral absorption_Homo sapiens_hsa049780.34757818
129Type I diabetes mellitus_Homo sapiens_hsa049400.33918750
130Tyrosine metabolism_Homo sapiens_hsa003500.33638625
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32405773
132Long-term depression_Homo sapiens_hsa047300.32249448
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31977658
134ECM-receptor interaction_Homo sapiens_hsa045120.31268253
135Inositol phosphate metabolism_Homo sapiens_hsa005620.29614858
136Fatty acid metabolism_Homo sapiens_hsa012120.28992807
137Base excision repair_Homo sapiens_hsa034100.28057731
138Sulfur relay system_Homo sapiens_hsa041220.27618822
139Wnt signaling pathway_Homo sapiens_hsa043100.26818864
140ABC transporters_Homo sapiens_hsa020100.25790049
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24429392
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24356121
143Carbon metabolism_Homo sapiens_hsa012000.20660053
144Antigen processing and presentation_Homo sapiens_hsa046120.20642429
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18286305

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