HSPB1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)9.50031129
2ATP synthesis coupled proton transport (GO:0015986)9.50031129
3positive regulation of vesicle fusion (GO:0031340)8.09932510
4viral transcription (GO:0019083)8.08091527
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.84762548
6translational termination (GO:0006415)7.78812883
7ribosomal small subunit assembly (GO:0000028)7.56363391
8response to dietary excess (GO:0002021)7.03263928
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.59136138
10cotranslational protein targeting to membrane (GO:0006613)6.47480363
11protein targeting to ER (GO:0045047)6.39288830
12translational elongation (GO:0006414)6.26759165
13establishment of protein localization to endoplasmic reticulum (GO:0072599)6.15081983
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.11641456
15protein localization to endoplasmic reticulum (GO:0070972)6.00675074
16cellular protein complex disassembly (GO:0043624)5.90191643
17viral life cycle (GO:0019058)5.82667724
18respiratory electron transport chain (GO:0022904)5.65162094
19ribosomal small subunit biogenesis (GO:0042274)5.64817147
20electron transport chain (GO:0022900)5.56119712
21autophagic vacuole fusion (GO:0000046)5.52049877
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.50023919
23ATP biosynthetic process (GO:0006754)5.36025570
24translational initiation (GO:0006413)5.22480023
25maturation of SSU-rRNA (GO:0030490)5.22069064
26protein complex disassembly (GO:0043241)5.19348380
27macromolecular complex disassembly (GO:0032984)4.91125302
28preassembly of GPI anchor in ER membrane (GO:0016254)4.83734839
29protein targeting to membrane (GO:0006612)4.58425109
30establishment of protein localization to mitochondrial membrane (GO:0090151)4.47100088
31ribosome assembly (GO:0042255)4.43774371
32protein-cofactor linkage (GO:0018065)4.35274758
33hydrogen ion transmembrane transport (GO:1902600)4.34696281
34purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.31064400
35purine nucleoside triphosphate biosynthetic process (GO:0009145)4.17828569
36translation (GO:0006412)4.00519126
37short-chain fatty acid metabolic process (GO:0046459)3.99212314
38proton transport (GO:0015992)3.96199335
39organelle membrane fusion (GO:0090174)3.94191668
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.90746196
41NADH dehydrogenase complex assembly (GO:0010257)3.90746196
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.90746196
43hydrogen transport (GO:0006818)3.87555572
44proteasome assembly (GO:0043248)3.79177626
45GPI anchor biosynthetic process (GO:0006506)3.78513306
46positive regulation of prostaglandin secretion (GO:0032308)3.78238597
47protein neddylation (GO:0045116)3.76133931
48ribonucleoside triphosphate biosynthetic process (GO:0009201)3.65311058
49intracellular protein transmembrane import (GO:0044743)3.61956968
50response to redox state (GO:0051775)3.59231424
51response to food (GO:0032094)3.51654355
52chaperone-mediated protein transport (GO:0072321)3.51342673
53nuclear-transcribed mRNA catabolic process (GO:0000956)3.47147964
54protoporphyrinogen IX biosynthetic process (GO:0006782)3.42734196
55positive regulation of megakaryocyte differentiation (GO:0045654)3.42297205
56S-adenosylmethionine metabolic process (GO:0046500)3.40838380
57GPI anchor metabolic process (GO:0006505)3.36499873
58protein complex biogenesis (GO:0070271)3.35681776
59C-terminal protein lipidation (GO:0006501)3.29489802
60establishment of protein localization to membrane (GO:0090150)3.28444755
61mRNA catabolic process (GO:0006402)3.26933102
62positive regulation of icosanoid secretion (GO:0032305)3.23514147
63positive regulation of sodium ion transmembrane transport (GO:1902307)3.23194066
64deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.21959645
65nucleoside triphosphate biosynthetic process (GO:0009142)3.19849586
66ribosomal large subunit biogenesis (GO:0042273)3.19837162
67purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.14549640
68purine nucleoside monophosphate biosynthetic process (GO:0009127)3.14549640
69regulation of vesicle fusion (GO:0031338)3.14218038
70mitochondrial respiratory chain complex assembly (GO:0033108)3.09511742
71muscle organ morphogenesis (GO:0048644)3.08033523
72neuron fate determination (GO:0048664)3.05404273
73membrane repolarization (GO:0086009)3.00634558
74potassium ion export (GO:0071435)3.00135794
75positive regulation of fatty acid transport (GO:2000193)2.95661558
76epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95455867
77protein targeting (GO:0006605)2.95142767
78protein transmembrane transport (GO:0071806)2.92257512
79regulation of prostaglandin secretion (GO:0032306)2.87878937
80spermatid nucleus differentiation (GO:0007289)2.87222092
81establishment of protein localization to mitochondrion (GO:0072655)2.85482596
82positive regulation of potassium ion transmembrane transport (GO:1901381)2.83400528
83primitive streak formation (GO:0090009)2.79967562
84RNA catabolic process (GO:0006401)2.77747646
85establishment of protein localization to organelle (GO:0072594)2.77553997
86mitochondrial transport (GO:0006839)2.73571352
87protein targeting to mitochondrion (GO:0006626)2.73282939
88C-terminal protein amino acid modification (GO:0018410)2.69959653
89cellular response to ATP (GO:0071318)2.69533438
90negative regulation of cardiac muscle hypertrophy (GO:0010614)2.67623169
91negative regulation of neurotransmitter secretion (GO:0046929)2.65122725
92positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.65082415
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.60871858
94positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.58726395
95intracellular protein transmembrane transport (GO:0065002)2.58191542
96myoblast migration (GO:0051451)2.58024772
972-deoxyribonucleotide biosynthetic process (GO:0009265)2.57907439
98deoxyribose phosphate biosynthetic process (GO:0046385)2.57907439
99oxygen transport (GO:0015671)12.1873617
100gas transport (GO:0015669)10.2425219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.28676720
2CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.19975439
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.97789196
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.52638387
5ZNF263_19887448_ChIP-Seq_K562_Human3.22281445
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09217933
7VDR_22108803_ChIP-Seq_LS180_Human3.07254372
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.75359279
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72387427
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.59548588
11POU5F1_16153702_ChIP-ChIP_HESCs_Human2.58147456
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45411662
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.36685746
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34661267
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.11636032
16ZNF274_21170338_ChIP-Seq_K562_Hela2.10406466
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08584651
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07266591
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02317249
20EZH2_22144423_ChIP-Seq_EOC_Human2.02057073
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.01892069
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00941197
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89487212
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88197000
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80844460
26FUS_26573619_Chip-Seq_HEK293_Human1.79764363
27ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73094183
28MYC_18940864_ChIP-ChIP_HL60_Human1.68222945
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.67185568
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.66725670
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56662958
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55736235
33TTF2_22483619_ChIP-Seq_HELA_Human1.55538031
34XRN2_22483619_ChIP-Seq_HELA_Human1.53300716
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53223358
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.52403038
37VDR_23849224_ChIP-Seq_CD4+_Human1.51155376
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.50850545
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47769020
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.47756578
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.47590343
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45353560
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43600896
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43131886
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.41601491
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41382662
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40019819
48DCP1A_22483619_ChIP-Seq_HELA_Human1.39834274
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35196128
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34971980
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.34686651
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33221143
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31016145
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30018180
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.27977193
56EWS_26573619_Chip-Seq_HEK293_Human1.27385807
57P53_21459846_ChIP-Seq_SAOS-2_Human1.26066129
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25188957
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25151446
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21757335
61TP53_22573176_ChIP-Seq_HFKS_Human1.21348248
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21069032
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20026133
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.18108779
65RNF2_27304074_Chip-Seq_NSC_Mouse1.17646457
66CTCF_20526341_ChIP-Seq_ESCs_Human1.16823639
67IGF1R_20145208_ChIP-Seq_DFB_Human1.16804469
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13713195
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13519270
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12959806
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12959806
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12959806
73ERG_20517297_ChIP-Seq_VCAP_Human1.10122421
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09091193
75GBX2_23144817_ChIP-Seq_PC3_Human1.08462723
76NANOG_20526341_ChIP-Seq_ESCs_Human1.07929632
77TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05768546
78NANOG_19829295_ChIP-Seq_ESCs_Human1.05229617
79SOX2_19829295_ChIP-Seq_ESCs_Human1.05229617
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03592134
81ERA_21632823_ChIP-Seq_H3396_Human1.02526798
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01332855
83TP53_20018659_ChIP-ChIP_R1E_Mouse1.01080279
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00003085
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99763806
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98260324
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97907681
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95900783
89EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95591930
90RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95591930
91E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94711544
92TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93432400
93SOX2_22085726_ChIP-Seq_NPCs_Mouse0.93202650
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93184273
95EZH2_27294783_Chip-Seq_ESCs_Mouse0.92411758
96RNF2_27304074_Chip-Seq_ESCs_Mouse0.91907276
97P300_19829295_ChIP-Seq_ESCs_Human0.91479039
98SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90622544
99SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90370254
100ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90313998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.15745281
2MP0003136_yellow_coat_color5.96210130
3MP0001188_hyperpigmentation5.14285805
4MP0004885_abnormal_endolymph4.91345920
5MP0000372_irregular_coat_pigmentation4.47608862
6MP0005377_hearing/vestibular/ear_phenot4.46950045
7MP0003878_abnormal_ear_physiology4.46950045
8MP0004147_increased_porphyrin_level3.89340819
9MP0000749_muscle_degeneration2.05777131
10MP0003011_delayed_dark_adaptation1.94774030
11MP0002277_abnormal_respiratory_mucosa1.94723528
12MP0004145_abnormal_muscle_electrophysio1.81710726
13MP0002163_abnormal_gland_morphology1.80895722
14MP0003806_abnormal_nucleotide_metabolis1.78922559
15MP0004142_abnormal_muscle_tone1.72754130
16MP0002822_catalepsy1.69718439
17MP0002095_abnormal_skin_pigmentation1.68370732
18MP0003656_abnormal_erythrocyte_physiolo1.66855922
19MP0006292_abnormal_olfactory_placode1.66376936
20MP0005075_abnormal_melanosome_morpholog1.63789490
21MP0000566_synostosis1.62781238
22MP0000579_abnormal_nail_morphology1.59649742
23MP0000631_abnormal_neuroendocrine_gland1.56028821
24MP0001485_abnormal_pinna_reflex1.55312573
25MP0003186_abnormal_redox_activity1.54809318
26MP0009046_muscle_twitch1.49205408
27MP0008875_abnormal_xenobiotic_pharmacok1.45935019
28MP0001486_abnormal_startle_reflex1.34997293
29MP0005646_abnormal_pituitary_gland1.34646678
30MP0003879_abnormal_hair_cell1.34479327
31MP0005187_abnormal_penis_morphology1.29385628
32MP0005084_abnormal_gallbladder_morpholo1.28194839
33MP0000026_abnormal_inner_ear1.24803681
34MP0001529_abnormal_vocalization1.23212105
35MP0001545_abnormal_hematopoietic_system1.20721714
36MP0005397_hematopoietic_system_phenotyp1.20721714
37MP0002132_abnormal_respiratory_system1.19048683
38MP0002249_abnormal_larynx_morphology1.14668380
39MP0000750_abnormal_muscle_regeneration1.12337022
40MP0002938_white_spotting1.10139169
41MP0005174_abnormal_tail_pigmentation1.05358213
42MP0003786_premature_aging1.03413448
43MP0002653_abnormal_ependyma_morphology1.02923020
44MP0003941_abnormal_skin_development1.02026816
45MP0003880_abnormal_central_pattern1.00247245
46MP0006276_abnormal_autonomic_nervous0.99732535
47MP0006072_abnormal_retinal_apoptosis0.97728592
48MP0003567_abnormal_fetal_cardiomyocyte0.96442753
49MP0004381_abnormal_hair_follicle0.95453256
50MP0003195_calcinosis0.94700551
51MP0005220_abnormal_exocrine_pancreas0.92415364
52MP0002928_abnormal_bile_duct0.90152916
53MP0008872_abnormal_physiological_respon0.89074179
54MP0000015_abnormal_ear_pigmentation0.88249016
55MP0001963_abnormal_hearing_physiology0.87864473
56MP0000467_abnormal_esophagus_morphology0.86451138
57MP0000762_abnormal_tongue_morphology0.86287841
58MP0001299_abnormal_eye_distance/0.86112159
59MP0004272_abnormal_basement_membrane0.85867238
60MP0008995_early_reproductive_senescence0.82498185
61MP0004215_abnormal_myocardial_fiber0.82062801
62MP0000681_abnormal_thyroid_gland0.81806024
63MP0005503_abnormal_tendon_morphology0.81573608
64MP0000534_abnormal_ureter_morphology0.80802577
65MP0005085_abnormal_gallbladder_physiolo0.80149798
66MP0005379_endocrine/exocrine_gland_phen0.79778169
67MP0004742_abnormal_vestibular_system0.79733770
68MP0003137_abnormal_impulse_conducting0.78664464
69MP0002697_abnormal_eye_size0.76301064
70MP0001905_abnormal_dopamine_level0.72489278
71MP0009250_abnormal_appendicular_skeleto0.71496423
72MP0001346_abnormal_lacrimal_gland0.70826762
73MP0001293_anophthalmia0.70791295
74MP0004133_heterotaxia0.69999842
75MP0005645_abnormal_hypothalamus_physiol0.68306208
76MP0005595_abnormal_vascular_smooth0.65670347
77MP0002269_muscular_atrophy0.65627225
78MP0000516_abnormal_urinary_system0.65157430
79MP0005367_renal/urinary_system_phenotyp0.65157430
80MP0001919_abnormal_reproductive_system0.64087932
81MP0009697_abnormal_copulation0.61500453
82MP0005636_abnormal_mineral_homeostasis0.59683636
83MP0001286_abnormal_eye_development0.57871482
84MP0005253_abnormal_eye_physiology0.57770838
85MP0002234_abnormal_pharynx_morphology0.57122483
86MP0000343_altered_response_to0.56207383
87MP0002735_abnormal_chemical_nociception0.55973389
88MP0001186_pigmentation_phenotype0.54502928
89MP0006036_abnormal_mitochondrial_physio0.54271341
90MP0005193_abnormal_anterior_eye0.53898854
91MP0002177_abnormal_outer_ear0.53114738
92MP0001881_abnormal_mammary_gland0.52238881
93MP0001440_abnormal_grooming_behavior0.50966004
94MP0005058_abnormal_lysosome_morphology0.49916415
95MP0000230_abnormal_systemic_arterial0.49857740
96MP0010030_abnormal_orbit_morphology0.49632072
97MP0003315_abnormal_perineum_morphology0.49372850
98MP0000778_abnormal_nervous_system0.47802676
99MP0003942_abnormal_urinary_system0.47189132
100MP0003646_muscle_fatigue0.47035645

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)9.30302679
2Abnormality of the heme biosynthetic pathway (HP:0010472)7.89838723
3Pallor (HP:0000980)5.45127142
4Acute encephalopathy (HP:0006846)4.54285791
5Lipid accumulation in hepatocytes (HP:0006561)4.53693097
63-Methylglutaconic aciduria (HP:0003535)4.48577169
7Acute necrotizing encephalopathy (HP:0006965)4.23146997
8Increased hepatocellular lipid droplets (HP:0006565)4.04631472
9Abnormality of cells of the erythroid lineage (HP:0012130)4.01213600
10Mitochondrial inheritance (HP:0001427)3.90417115
11Decreased central vision (HP:0007663)3.87466181
12Abnormal mitochondria in muscle tissue (HP:0008316)3.83543353
13Abnormal number of erythroid precursors (HP:0012131)3.82695882
14Renal Fanconi syndrome (HP:0001994)3.82498158
15Increased intramyocellular lipid droplets (HP:0012240)3.77818906
16Increased muscle lipid content (HP:0009058)3.75315948
17Methylmalonic acidemia (HP:0002912)3.69125750
18Exertional dyspnea (HP:0002875)3.54539606
19Progressive macrocephaly (HP:0004481)3.38323327
20Increased CSF lactate (HP:0002490)3.19639680
21Macrocytic anemia (HP:0001972)3.17531417
22Hepatocellular necrosis (HP:0001404)3.14745681
23Hepatic necrosis (HP:0002605)3.03607537
24Reticulocytopenia (HP:0001896)3.01493395
25Neoplasm of head and neck (HP:0012288)2.92280059
26Esophageal neoplasm (HP:0100751)2.92280059
27Respiratory difficulties (HP:0002880)2.82631608
28Absent eyebrow (HP:0002223)2.74025251
29Nausea (HP:0002018)2.73036949
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70988043
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70988043
32Type 2 muscle fiber atrophy (HP:0003554)2.70795941
33Concave nail (HP:0001598)2.69337083
34Testicular atrophy (HP:0000029)2.65875801
35Distal arthrogryposis (HP:0005684)2.56778883
36Degeneration of the lateral corticospinal tracts (HP:0002314)2.54201625
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54201625
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.45686407
39Methylmalonic aciduria (HP:0012120)2.42632055
40Type II lissencephaly (HP:0007260)2.40863032
41Abnormality of reticulocytes (HP:0004312)2.40764056
42Microcytic anemia (HP:0001935)2.40012916
43Septo-optic dysplasia (HP:0100842)2.38403713
44Congenital, generalized hypertrichosis (HP:0004540)2.37949405
45Generalized aminoaciduria (HP:0002909)2.36263791
46Fatigable weakness (HP:0003473)2.35573731
47Abnormality of the neuromuscular junction (HP:0003398)2.35573731
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.31022471
49Absent/shortened dynein arms (HP:0200106)2.30733273
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.30733273
51Cerebral edema (HP:0002181)2.29671637
52Abnormality of renal resorption (HP:0011038)2.29315825
53Glycosuria (HP:0003076)2.25930402
54Abnormality of urine glucose concentration (HP:0011016)2.25930402
55Absent phalangeal crease (HP:0006109)2.23563103
56Hypertensive crisis (HP:0100735)2.20600141
57Muscle fiber atrophy (HP:0100295)2.19254503
58Absent septum pellucidum (HP:0001331)2.17353461
59Optic disc pallor (HP:0000543)2.14732843
60Retinal dysplasia (HP:0007973)2.13765345
61Submucous cleft hard palate (HP:0000176)2.12308744
62Reticulocytosis (HP:0001923)2.11997526
63Hyperphosphaturia (HP:0003109)2.10314059
64Degeneration of anterior horn cells (HP:0002398)2.10046016
65Abnormality of the anterior horn cell (HP:0006802)2.10046016
66Abnormality of homocysteine metabolism (HP:0010919)2.07072966
67Homocystinuria (HP:0002156)2.07072966
68Delayed CNS myelination (HP:0002188)2.07027445
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06378882
70Abnormal finger flexion creases (HP:0006143)2.04689013
71Calcaneovalgus deformity (HP:0001848)2.04056293
72Abnormality of the vitamin B12 metabolism (HP:0004341)2.03029461
73Calf muscle hypertrophy (HP:0008981)2.01962020
74Anteriorly placed anus (HP:0001545)1.99829221
75Exercise intolerance (HP:0003546)1.96671656
76Weak cry (HP:0001612)1.96042927
77Ulnar deviation of the wrist (HP:0003049)1.89297438
78Abnormality of vitamin B metabolism (HP:0004340)1.89267847
79Breech presentation (HP:0001623)1.88820895
80Thickened helices (HP:0000391)1.88768830
81Hyperthyroidism (HP:0000836)1.88509530
82Deformed tarsal bones (HP:0008119)1.88110772
83Alveolar cell carcinoma (HP:0006519)1.87819283
84Muscle hypertrophy of the lower extremities (HP:0008968)1.87249237
85Absent eyelashes (HP:0000561)1.87034290
86Abnormality of placental membranes (HP:0011409)1.86851039
87Amniotic constriction ring (HP:0009775)1.86851039
88Leukodystrophy (HP:0002415)1.86316874
89Respiratory failure (HP:0002878)1.83968437
90Diaphragmatic weakness (HP:0009113)1.83036952
91Split foot (HP:0001839)1.80580152
92Microretrognathia (HP:0000308)1.79463255
93Ileus (HP:0002595)1.77953296
94Ulnar claw (HP:0001178)1.75930079
95Metatarsus adductus (HP:0001840)1.75138248
96Hypochromic microcytic anemia (HP:0004840)1.74093728
97Absent hair (HP:0002298)1.73331396
98Abnormality of midbrain morphology (HP:0002418)1.72715066
99Molar tooth sign on MRI (HP:0002419)1.72715066
100Round ear (HP:0100830)1.70066469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT39.34126124
2MAPK154.39443530
3BRAF3.47373639
4MAP3K123.24862305
5PNCK2.58352341
6WEE12.46387086
7ILK2.10439337
8NME12.05827634
9PINK11.99455154
10TIE11.97220074
11PLK41.69556831
12ZAK1.62211922
13TLK11.59385860
14NME21.51635798
15DAPK21.48967481
16TSSK61.34108388
17VRK11.33398759
18DYRK21.32632216
19RPS6KA41.28813779
20CDK31.27877178
21MUSK1.27275532
22LATS11.22889178
23GRK11.22100605
24CDK191.19227655
25INSRR1.18504829
26DYRK31.16350697
27DYRK1B1.11137550
28RPS6KA51.09976865
29BMPR21.09843384
30MAP3K101.06802422
31OBSCN1.06232427
32PIK3CG1.06214533
33ADRBK11.03426408
34CASK1.01530909
35ADRBK21.01014981
36DMPK0.99826960
37MYLK0.99617911
38SGK20.98614639
39SGK4940.96662261
40SGK2230.96662261
41PKN10.81016986
42NUAK10.79643530
43EPHB20.76468435
44WNK30.76336640
45TGFBR10.71707092
46DAPK30.69870060
47STK240.68557528
48MAP3K110.67016475
49CSNK2A20.64019112
50MOS0.63801603
51AURKA0.61383150
52FLT30.61172377
53CCNB10.61126209
54AURKB0.60991800
55BMX0.60340889
56NTRK10.59111686
57IRAK40.58894297
58PRKG10.58399484
59TNIK0.58353167
60PRKACA0.56427557
61STK30.53275198
62VRK20.49342550
63PASK0.47287296
64TXK0.44573264
65BUB10.44337116
66RPS6KA60.43040810
67TRPM70.42927693
68DYRK1A0.42454802
69SGK10.40408757
70NEK10.40390576
71PRKCG0.38500402
72MARK10.37857113
73CAMK2G0.37624107
74EIF2AK20.35212405
75CSNK2A10.35122351
76PDK20.32408221
77PRKCQ0.32087647
78CAMK10.31337768
79CHEK20.30460597
80ROCK10.30385200
81CDK120.30145904
82NTRK20.29632610
83RPS6KB20.29078553
84CDK80.28178662
85CDC70.28076745
86GSK3A0.27331132
87EPHA40.26829517
88CAMK2D0.26622056
89WNK40.26352795
90MAP2K40.25960770
91LRRK20.25934840
92SGK30.25523336
93PAK20.24757254
94CSNK1A10.23536175
95PRKACG0.23211920
96PRKACB0.23127229
97CAMK2A0.22807080
98GRK70.22792309
99MAPKAPK50.21946589
100DDR20.21260015

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.70829077
2Oxidative phosphorylation_Homo sapiens_hsa001905.91882167
3Parkinsons disease_Homo sapiens_hsa050124.85324830
4Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.50408906
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.50254495
6Cardiac muscle contraction_Homo sapiens_hsa042603.42157410
7Alzheimers disease_Homo sapiens_hsa050103.37287954
8Huntingtons disease_Homo sapiens_hsa050163.21024817
9Proteasome_Homo sapiens_hsa030502.35744713
10Protein export_Homo sapiens_hsa030602.07224447
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.77548129
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.72130293
13RNA polymerase_Homo sapiens_hsa030201.60440801
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51315318
15Phenylalanine metabolism_Homo sapiens_hsa003601.48152264
16Homologous recombination_Homo sapiens_hsa034401.47406729
17Nitrogen metabolism_Homo sapiens_hsa009101.47382800
18Butanoate metabolism_Homo sapiens_hsa006501.32930444
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24618951
20Asthma_Homo sapiens_hsa053101.22687486
21Malaria_Homo sapiens_hsa051441.15840649
22One carbon pool by folate_Homo sapiens_hsa006701.10935911
23Propanoate metabolism_Homo sapiens_hsa006401.09377801
24Linoleic acid metabolism_Homo sapiens_hsa005911.07631574
25Caffeine metabolism_Homo sapiens_hsa002321.07565169
26Tyrosine metabolism_Homo sapiens_hsa003501.07439220
27Olfactory transduction_Homo sapiens_hsa047401.03361199
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86531532
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84922253
30Chemical carcinogenesis_Homo sapiens_hsa052040.84579277
31Fatty acid elongation_Homo sapiens_hsa000620.82932913
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80833198
33beta-Alanine metabolism_Homo sapiens_hsa004100.77909947
34Peroxisome_Homo sapiens_hsa041460.77068590
35Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75398577
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73606673
37Bladder cancer_Homo sapiens_hsa052190.72586666
38Basal cell carcinoma_Homo sapiens_hsa052170.71619703
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69385156
40Basal transcription factors_Homo sapiens_hsa030220.68302145
41Rheumatoid arthritis_Homo sapiens_hsa053230.67476344
42Metabolic pathways_Homo sapiens_hsa011000.67447080
43Fanconi anemia pathway_Homo sapiens_hsa034600.66972196
44Collecting duct acid secretion_Homo sapiens_hsa049660.66634708
45Retinol metabolism_Homo sapiens_hsa008300.66437084
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63815288
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61863160
48Nucleotide excision repair_Homo sapiens_hsa034200.59706849
49Mismatch repair_Homo sapiens_hsa034300.57545289
50Nicotine addiction_Homo sapiens_hsa050330.54965345
51Protein digestion and absorption_Homo sapiens_hsa049740.54555393
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.50863237
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.50402386
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49631539
55Vitamin digestion and absorption_Homo sapiens_hsa049770.49626851
56Mineral absorption_Homo sapiens_hsa049780.49359027
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.49227521
58Purine metabolism_Homo sapiens_hsa002300.49171361
59Taste transduction_Homo sapiens_hsa047420.48963130
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48721033
61Phototransduction_Homo sapiens_hsa047440.48263820
62DNA replication_Homo sapiens_hsa030300.47486311
63Systemic lupus erythematosus_Homo sapiens_hsa053220.47449653
64Hedgehog signaling pathway_Homo sapiens_hsa043400.44813035
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43396828
66Melanoma_Homo sapiens_hsa052180.43260021
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41320229
68Fat digestion and absorption_Homo sapiens_hsa049750.40729475
69Pyruvate metabolism_Homo sapiens_hsa006200.40547072
70Steroid biosynthesis_Homo sapiens_hsa001000.37496804
71African trypanosomiasis_Homo sapiens_hsa051430.37068076
72Tryptophan metabolism_Homo sapiens_hsa003800.36722959
73Arachidonic acid metabolism_Homo sapiens_hsa005900.36246405
74Arginine biosynthesis_Homo sapiens_hsa002200.35395334
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34899644
76Pyrimidine metabolism_Homo sapiens_hsa002400.33845164
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32618417
78Circadian rhythm_Homo sapiens_hsa047100.32528651
79Antigen processing and presentation_Homo sapiens_hsa046120.32109595
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31987004
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31745203
82Sulfur relay system_Homo sapiens_hsa041220.29045546
83Glutathione metabolism_Homo sapiens_hsa004800.26681169
84Vibrio cholerae infection_Homo sapiens_hsa051100.24055538
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22956810
86Spliceosome_Homo sapiens_hsa030400.22485910
87Notch signaling pathway_Homo sapiens_hsa043300.21237744
88GABAergic synapse_Homo sapiens_hsa047270.20772139
89RNA degradation_Homo sapiens_hsa030180.20658672
90Serotonergic synapse_Homo sapiens_hsa047260.20464749
91Morphine addiction_Homo sapiens_hsa050320.20140104
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19590253
93Autoimmune thyroid disease_Homo sapiens_hsa053200.18158560
94Alcoholism_Homo sapiens_hsa050340.17264217
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16919658
96Arginine and proline metabolism_Homo sapiens_hsa003300.16207145
97RNA transport_Homo sapiens_hsa030130.15620696
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.14434723
99Bile secretion_Homo sapiens_hsa049760.14005297
100Graft-versus-host disease_Homo sapiens_hsa053320.13781915

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