HSPB1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)6.64694024
2cytidine metabolic process (GO:0046087)6.64694024
3cytidine catabolic process (GO:0006216)6.64694024
4DNA deamination (GO:0045006)6.54830905
5regulation of activation of Janus kinase activity (GO:0010533)5.88838224
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.71896832
7T cell migration (GO:0072678)5.37788950
8regulation of chronic inflammatory response (GO:0002676)5.33458256
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.14153200
10regulation of macrophage chemotaxis (GO:0010758)5.07899232
11negative regulation by host of viral transcription (GO:0043922)4.97991233
12eosinophil chemotaxis (GO:0048245)4.84491543
13negative T cell selection (GO:0043383)4.54872268
14negative regulation of T cell apoptotic process (GO:0070233)4.52630217
15positive thymic T cell selection (GO:0045059)4.47089910
16eosinophil migration (GO:0072677)4.37292147
17regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.36522301
18mast cell degranulation (GO:0043303)4.31817134
19mast cell activation involved in immune response (GO:0002279)4.31817134
20negative thymic T cell selection (GO:0045060)4.29404500
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.27553990
22positive regulation of calcium-mediated signaling (GO:0050850)4.27506007
23regulation of chemokine-mediated signaling pathway (GO:0070099)4.26581384
24cellular response to interleukin-15 (GO:0071350)4.16966710
25macrophage chemotaxis (GO:0048246)4.14661153
26regulation of mononuclear cell migration (GO:0071675)4.10796947
27positive T cell selection (GO:0043368)4.05931556
28positive regulation of T cell apoptotic process (GO:0070234)4.05716233
29blood vessel maturation (GO:0001955)3.98495854
30positive regulation of gamma-delta T cell activation (GO:0046645)3.97616835
31regulation of regulatory T cell differentiation (GO:0045589)3.97231119
32thymic T cell selection (GO:0045061)3.95481580
33ribosomal small subunit assembly (GO:0000028)3.87937538
34negative regulation of execution phase of apoptosis (GO:1900118)3.83009192
35negative regulation of lymphocyte apoptotic process (GO:0070229)3.80953696
36negative regulation of viral genome replication (GO:0045071)3.80763000
37positive regulation of interleukin-8 secretion (GO:2000484)3.75248413
38sequestering of actin monomers (GO:0042989)3.64374678
39chaperone-mediated protein transport (GO:0072321)3.61673267
40positive regulation of monocyte chemotaxis (GO:0090026)3.61632758
41positive regulation of B cell differentiation (GO:0045579)3.58202041
42positive regulation of alpha-beta T cell proliferation (GO:0046641)3.52388840
43chaperone mediated protein folding requiring cofactor (GO:0051085)3.42956218
44cytolysis (GO:0019835)3.42943488
45lymphocyte chemotaxis (GO:0048247)3.37574402
46lymphocyte migration (GO:0072676)3.37302543
47positive regulation of defense response to virus by host (GO:0002230)3.36110699
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31494395
49positive regulation of lymphocyte apoptotic process (GO:0070230)3.31360902
50positive regulation of T cell chemotaxis (GO:0010820)3.20933319
51regulation of T cell chemotaxis (GO:0010819)3.20933319
52pyrimidine nucleoside catabolic process (GO:0046135)3.20182569
53regulation of B cell differentiation (GO:0045577)3.16995128
54response to interleukin-15 (GO:0070672)3.15256017
55immunoglobulin mediated immune response (GO:0016064)3.13883769
56regulation of lymphocyte chemotaxis (GO:1901623)3.13373822
57modulation by host of viral transcription (GO:0043921)3.13362553
58modulation by host of symbiont transcription (GO:0052472)3.13362553
59T cell selection (GO:0045058)3.13146896
60metallo-sulfur cluster assembly (GO:0031163)3.12071773
61iron-sulfur cluster assembly (GO:0016226)3.12071773
62regulation of interleukin-2 biosynthetic process (GO:0045076)3.11039997
63monocyte chemotaxis (GO:0002548)3.10473139
64positive regulation of interleukin-4 production (GO:0032753)3.10198760
65positive regulation of natural killer cell mediated immunity (GO:0002717)3.08283683
66regulation of alpha-beta T cell proliferation (GO:0046640)3.07128772
67regulation of gamma-delta T cell differentiation (GO:0045586)3.01987947
68positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.01601003
69actin nucleation (GO:0045010)2.94962506
70response to interferon-beta (GO:0035456)2.92454918
71modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.92172024
72T cell receptor signaling pathway (GO:0050852)2.91313351
73regulation of calcium-mediated signaling (GO:0050848)2.90403939
74positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.86540741
75positive regulation of lymphocyte migration (GO:2000403)2.84115425
76DNA damage response, detection of DNA damage (GO:0042769)2.82753210
77mast cell activation (GO:0045576)2.81180613
78regulation of T cell apoptotic process (GO:0070232)2.80001252
79positive regulation of tolerance induction (GO:0002645)2.78614216
80negative regulation of telomere maintenance (GO:0032205)2.76661366
81negative regulation of leukocyte apoptotic process (GO:2000107)2.75954730
82protein deneddylation (GO:0000338)2.75069036
83translational termination (GO:0006415)2.73335365
84negative regulation of B cell apoptotic process (GO:0002903)2.73317736
85positive regulation of prostaglandin secretion (GO:0032308)2.72868368
86viral transcription (GO:0019083)2.72782200
87B cell mediated immunity (GO:0019724)2.72483744
88regulation of interleukin-8 secretion (GO:2000482)2.72038711
89regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.71849585
90regulation of natural killer cell mediated immunity (GO:0002715)2.71849585
91T cell costimulation (GO:0031295)2.68438747
92regulation of viral genome replication (GO:0045069)2.65689993
93GTP biosynthetic process (GO:0006183)2.65324840
94lymphocyte costimulation (GO:0031294)2.64858293
95regulation of T cell receptor signaling pathway (GO:0050856)2.64750913
96leukocyte degranulation (GO:0043299)2.62982230
97negative regulation of B cell proliferation (GO:0030889)2.62685595
98inflammatory response to antigenic stimulus (GO:0002437)2.62491182
99regulation of translational termination (GO:0006449)2.61886018
100regulation of defense response to virus by host (GO:0050691)2.61777867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.84582022
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.10271726
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.79445789
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.34828806
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.98121525
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.64124845
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.59361753
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52353275
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39088650
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29513206
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.26685691
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23459483
13MYB_26560356_Chip-Seq_TH2_Human2.19821912
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16305424
15FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12358336
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11349788
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.09086779
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.08415425
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04276702
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.95102131
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.91819328
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.90793720
23VDR_23849224_ChIP-Seq_CD4+_Human1.86578738
24MYB_26560356_Chip-Seq_TH1_Human1.82482161
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81006585
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.80001603
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79470589
28LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78500378
29EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.76421484
30RUNX_20019798_ChIP-Seq_JUKART_Human1.74499959
31SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70420443
32SCL_19346495_ChIP-Seq_HPC-7_Human1.69342630
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68510205
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67888750
35FOXP3_21729870_ChIP-Seq_TREG_Human1.66645270
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63212463
37RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.60700573
38CIITA_25753668_ChIP-Seq_RAJI_Human1.59997688
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57879878
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57610370
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57582508
42UTX_26944678_Chip-Seq_JUKART_Human1.57435469
43BCL6_27268052_Chip-Seq_Bcells_Human1.56748470
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.55579550
45MYC_18940864_ChIP-ChIP_HL60_Human1.54818538
46GATA3_26560356_Chip-Seq_TH2_Human1.47424398
47GATA3_27048872_Chip-Seq_THYMUS_Human1.43412881
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.35722024
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33973421
50MAF_26560356_Chip-Seq_TH2_Human1.31763336
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31186771
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29428680
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28052141
54FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27282791
55IGF1R_20145208_ChIP-Seq_DFB_Human1.25699448
56VDR_21846776_ChIP-Seq_THP-1_Human1.25598162
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24556118
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.23571003
59VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21572452
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19274489
61TAF2_19829295_ChIP-Seq_ESCs_Human1.18147477
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16512616
63ZNF274_21170338_ChIP-Seq_K562_Hela1.16370938
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16227553
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15528426
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15197624
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15167063
68SPI1_23547873_ChIP-Seq_NB4_Human1.13319375
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13050508
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10658831
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10657814
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08289774
73P300_27268052_Chip-Seq_Bcells_Human1.07971285
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06017563
75NANOG_20526341_ChIP-Seq_ESCs_Human1.05754383
76MAF_26560356_Chip-Seq_TH1_Human1.05237427
77KDM5A_27292631_Chip-Seq_BREAST_Human1.05058381
78E2F1_20622854_ChIP-Seq_HELA_Human1.04224430
79RAC3_21632823_ChIP-Seq_H3396_Human1.02580468
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01681426
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00888165
82TP53_22573176_ChIP-Seq_HFKS_Human0.97058375
83THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95179864
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95150519
85CTCF_20526341_ChIP-Seq_ESCs_Human0.94089312
86ELK1_19687146_ChIP-ChIP_HELA_Human0.93686022
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92869787
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92668806
89VDR_22108803_ChIP-Seq_LS180_Human0.92241284
90GATA3_21878914_ChIP-Seq_MCF-7_Human0.91148592
91AR_20517297_ChIP-Seq_VCAP_Human0.91055594
92SA1_27219007_Chip-Seq_Bcells_Human0.90150309
93BCOR_27268052_Chip-Seq_Bcells_Human0.90117385
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87465000
95STAT1_20625510_ChIP-Seq_HELA_Human0.86276255
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85795450
97MYC_19829295_ChIP-Seq_ESCs_Human0.85740901
98CTCF_26484167_Chip-Seq_Bcells_Mouse0.82429405
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.82413862
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82114842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.95197723
2MP0004147_increased_porphyrin_level3.05842516
3MP0001835_abnormal_antigen_presentation2.77912936
4MP0003045_fibrosis2.65561834
5MP0009379_abnormal_foot_pigmentation2.60217345
6MP0000569_abnormal_digit_pigmentation2.57968496
7MP0006072_abnormal_retinal_apoptosis2.47040990
8MP0003763_abnormal_thymus_physiology2.45105315
9MP0005645_abnormal_hypothalamus_physiol2.42037283
10MP0009785_altered_susceptibility_to2.39438079
11MP0005000_abnormal_immune_tolerance2.37870449
12MP0002148_abnormal_hypersensitivity_rea2.32252178
13MP0006292_abnormal_olfactory_placode2.30342648
14MP0001529_abnormal_vocalization2.26989315
15MP0001800_abnormal_humoral_immune2.19020943
16MP0005025_abnormal_response_to2.17224358
17MP0002138_abnormal_hepatobiliary_system2.16608886
18MP0002420_abnormal_adaptive_immunity2.13247492
19MP0002723_abnormal_immune_serum2.12680754
20MP0003315_abnormal_perineum_morphology2.09657673
21MP0001819_abnormal_immune_cell2.03759764
22MP0001873_stomach_inflammation2.00492700
23MP0005360_urolithiasis1.99325813
24MP0003786_premature_aging1.97448921
25MP0002234_abnormal_pharynx_morphology1.87150983
26MP0003866_abnormal_defecation1.82041354
27MP0006082_CNS_inflammation1.81747818
28MP0003724_increased_susceptibility_to1.67569516
29MP0002398_abnormal_bone_marrow1.67001593
30MP0003436_decreased_susceptibility_to1.66895113
31MP0002452_abnormal_antigen_presenting1.63977760
32MP0000716_abnormal_immune_system1.62985170
33MP0002419_abnormal_innate_immunity1.51521970
34MP0009333_abnormal_splenocyte_physiolog1.49700979
35MP0000685_abnormal_immune_system1.47799925
36MP0004145_abnormal_muscle_electrophysio1.45431700
37MP0005387_immune_system_phenotype1.43961231
38MP0001790_abnormal_immune_system1.43961231
39MP0002722_abnormal_immune_system1.43843044
40MP0001905_abnormal_dopamine_level1.40683470
41MP0000703_abnormal_thymus_morphology1.36044311
42MP0000689_abnormal_spleen_morphology1.34857265
43MP0002933_joint_inflammation1.34450042
44MP0010155_abnormal_intestine_physiology1.34006975
45MP0002429_abnormal_blood_cell1.25811393
46MP0008007_abnormal_cellular_replicative1.25361378
47MP0001919_abnormal_reproductive_system1.21643310
48MP0008995_early_reproductive_senescence1.20233268
49MP0002405_respiratory_system_inflammati1.19397421
50MP0001845_abnormal_inflammatory_respons1.18239995
51MP0003646_muscle_fatigue1.17084911
52MP0000566_synostosis1.15509295
53MP0005551_abnormal_eye_electrophysiolog1.13916965
54MP0001968_abnormal_touch/_nociception1.13559312
55MP0002168_other_aberrant_phenotype1.13278287
56MP0002736_abnormal_nociception_after1.11099098
57MP0002277_abnormal_respiratory_mucosa1.08692059
58MP0002163_abnormal_gland_morphology1.07287376
59MP0005253_abnormal_eye_physiology1.06438285
60MP0000678_abnormal_parathyroid_gland1.05380992
61MP0005464_abnormal_platelet_physiology1.04777648
62MP0000465_gastrointestinal_hemorrhage1.04330249
63MP0000613_abnormal_salivary_gland1.03173788
64MP0002876_abnormal_thyroid_physiology1.02895497
65MP0002822_catalepsy1.00406575
66MP0005389_reproductive_system_phenotype0.97016306
67MP0003075_altered_response_to0.96108114
68MP0001661_extended_life_span0.93800005
69MP0008469_abnormal_protein_level0.91622919
70MP0002006_tumorigenesis0.91413410
71MP0002166_altered_tumor_susceptibility0.89753959
72MP0000538_abnormal_urinary_bladder0.89184068
73MP0005395_other_phenotype0.87208354
74MP0003448_altered_tumor_morphology0.85923885
75MP0009643_abnormal_urine_homeostasis0.84724615
76MP0008872_abnormal_physiological_respon0.83994367
77MP0001533_abnormal_skeleton_physiology0.83310260
78MP0000516_abnormal_urinary_system0.82337626
79MP0005367_renal/urinary_system_phenotyp0.82337626
80MP0002733_abnormal_thermal_nociception0.81569518
81MP0005167_abnormal_blood-brain_barrier0.81182020
82MP0008789_abnormal_olfactory_epithelium0.80126556
83MP0005379_endocrine/exocrine_gland_phen0.79909785
84MP0004742_abnormal_vestibular_system0.78898165
85MP0009763_increased_sensitivity_to0.76921368
86MP0005166_decreased_susceptibility_to0.76175668
87MP0005377_hearing/vestibular/ear_phenot0.75494521
88MP0003878_abnormal_ear_physiology0.75494521
89MP0003638_abnormal_response/metabolism_0.75394567
90MP0001764_abnormal_homeostasis0.74641099
91MP0002019_abnormal_tumor_incidence0.74563495
92MP0008873_increased_physiological_sensi0.74558636
93MP0008875_abnormal_xenobiotic_pharmacok0.72217223
94MP0000681_abnormal_thyroid_gland0.71175698
95MP0002693_abnormal_pancreas_physiology0.70215464
96MP0000920_abnormal_myelination0.66303242
97MP0001188_hyperpigmentation0.65607059
98MP0005636_abnormal_mineral_homeostasis0.63734885
99MP0005220_abnormal_exocrine_pancreas0.63228705
100MP0003693_abnormal_embryo_hatching0.62922722

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)5.74096060
2T lymphocytopenia (HP:0005403)5.53585426
3Aplastic anemia (HP:0001915)5.44382892
4Severe combined immunodeficiency (HP:0004430)4.57351309
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.45946790
6Decreased activity of mitochondrial respiratory chain (HP:0008972)4.45946790
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.28269217
8Congenital, generalized hypertrichosis (HP:0004540)4.13137506
9Increased intramyocellular lipid droplets (HP:0012240)4.01899753
10Autoimmune hemolytic anemia (HP:0001890)3.97343651
11Abnormality of T cells (HP:0002843)3.93066045
12Dry hair (HP:0011359)3.69161991
13Agammaglobulinemia (HP:0004432)3.65033169
14Panhypogammaglobulinemia (HP:0003139)3.53740891
15Increased muscle lipid content (HP:0009058)3.51961612
16Combined immunodeficiency (HP:0005387)3.48485606
17Recurrent cutaneous fungal infections (HP:0011370)3.43401191
18Chronic mucocutaneous candidiasis (HP:0002728)3.43401191
19Abnormality of eosinophils (HP:0001879)3.37142958
20IgG deficiency (HP:0004315)3.36663430
21Hepatocellular necrosis (HP:0001404)3.25838669
22Autoimmune thrombocytopenia (HP:0001973)3.22012173
23Hypoproteinemia (HP:0003075)3.12902147
24Thyroiditis (HP:0100646)3.11798017
25Increased IgM level (HP:0003496)3.09378126
26Elevated erythrocyte sedimentation rate (HP:0003565)3.03401603
27Hepatic necrosis (HP:0002605)3.02807877
28Delayed CNS myelination (HP:0002188)2.95814953
29Eosinophilia (HP:0001880)2.95645487
30Generalized aminoaciduria (HP:0002909)2.91030108
31Renal Fanconi syndrome (HP:0001994)2.89119776
32Recurrent fungal infections (HP:0002841)2.88968908
33Pustule (HP:0200039)2.84680393
34Mitochondrial inheritance (HP:0001427)2.75346982
35Abnormality of secondary sexual hair (HP:0009888)2.73476964
36Abnormality of the axillary hair (HP:0100134)2.73476964
37Pancytopenia (HP:0001876)2.73257577
38Abnormality of T cell physiology (HP:0011840)2.71381428
39Abnormality of the prostate (HP:0008775)2.71334274
40Recurrent viral infections (HP:0004429)2.71185913
41IgM deficiency (HP:0002850)2.68199190
42Abnormality of B cell number (HP:0010975)2.67026825
43Granulocytopenia (HP:0001913)2.65985820
44Abnormal mitochondria in muscle tissue (HP:0008316)2.60545794
45Pendular nystagmus (HP:0012043)2.59207891
46Leukocytosis (HP:0001974)2.56282914
47Encephalitis (HP:0002383)2.55468348
48Thrombocytosis (HP:0001894)2.53832578
49Increased hepatocellular lipid droplets (HP:0006565)2.51098585
50Meningitis (HP:0001287)2.50727030
51Ureteral stenosis (HP:0000071)2.50121573
52Lipid accumulation in hepatocytes (HP:0006561)2.42037626
53Oral leukoplakia (HP:0002745)2.40089622
54Ridged nail (HP:0001807)2.39995831
55Obstructive lung disease (HP:0006536)2.39951198
56Chronic obstructive pulmonary disease (HP:0006510)2.39951198
57Abnormality of the phalanges of the 2nd finger (HP:0009541)2.33510122
58Neutropenia (HP:0001875)2.33251669
59Ureteral obstruction (HP:0006000)2.30916419
60Congenital stationary night blindness (HP:0007642)2.30481697
61Increased CSF lactate (HP:0002490)2.30245400
62Renal cortical cysts (HP:0000803)2.13465017
63Acute encephalopathy (HP:0006846)2.10791672
64Tongue fasciculations (HP:0001308)2.10290164
65Sparse scalp hair (HP:0002209)2.08325802
66Sparse eyelashes (HP:0000653)2.06578969
67Abolished electroretinogram (ERG) (HP:0000550)2.06296246
68Hypoplasia of the thymus (HP:0000778)2.05325195
69Pulmonary fibrosis (HP:0002206)2.05051926
70Hypergammaglobulinemia (HP:0010702)2.05032009
71Stomatitis (HP:0010280)2.02427538
72Type I transferrin isoform profile (HP:0003642)2.01341361
73Hypotrichosis (HP:0001006)1.96647144
74Recurrent skin infections (HP:0001581)1.92010688
75Acute necrotizing encephalopathy (HP:0006965)1.90775311
76Abnormality of the renal cortex (HP:0011035)1.89862411
77Fair hair (HP:0002286)1.89795434
78Lactic acidosis (HP:0003128)1.87332868
79Muscle fibrillation (HP:0010546)1.86749606
80Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86124524
81Dicarboxylic aciduria (HP:0003215)1.86124524
82Reticulocytopenia (HP:0001896)1.85566847
83Squamous cell carcinoma (HP:0002860)1.82888939
84Increased serum lactate (HP:0002151)1.81124935
85Skin rash (HP:0000988)1.80212032
86Hypoplasia of the uterus (HP:0000013)1.78051081
87Abnormality of midbrain morphology (HP:0002418)1.77054999
88Molar tooth sign on MRI (HP:0002419)1.77054999
893-Methylglutaconic aciduria (HP:0003535)1.75932603
90Abnormal rod and cone electroretinograms (HP:0008323)1.75244162
91Mesangial abnormality (HP:0001966)1.74216176
92Chest pain (HP:0100749)1.73908014
93Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.72671803
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.70350923
95Methylmalonic acidemia (HP:0002912)1.70157065
96Slow-growing hair (HP:0002217)1.68986182
97Abnormality of hair growth rate (HP:0011363)1.68986182
98Chronic diarrhea (HP:0002028)1.68496521
99Polydipsia (HP:0001959)1.68265523
100Abnormal drinking behavior (HP:0030082)1.68265523

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.71867742
2TXK4.57102489
3MAPKAPK33.89321707
4KDR3.69952528
5MAP4K13.31263451
6BMPR1B3.20517855
7VRK22.92302281
8BCKDK2.70340973
9ADRBK22.12749793
10ITK1.92258326
11ARAF1.92255504
12CLK11.87744169
13PIM21.85766151
14TAOK31.81333460
15NME11.81191836
16SCYL21.75172043
17MAP4K21.70669963
18TGFBR11.64639592
19MAP3K111.58922330
20FES1.58499613
21SYK1.51007797
22TESK11.48779344
23DAPK21.46987208
24GRK71.41861408
25TEC1.40760131
26PRKCQ1.40379557
27SRPK11.36936105
28TBK11.34036224
29LIMK11.33075038
30BMPR21.29668379
31CDK81.28616917
32JAK31.25069005
33LCK1.24753487
34GRK11.19803383
35FRK1.17088681
36STK161.15243476
37WNK41.13217501
38FLT31.13131195
39PLK21.11606101
40KIT1.09783701
41RIPK41.04514911
42ZAP701.04212575
43GRK61.02535742
44CSK1.01950004
45BTK0.99622433
46LRRK20.97963325
47PRKCI0.97262780
48VRK10.87112600
49CSF1R0.84946765
50PIM10.83686620
51TIE10.82842748
52CSNK1G30.79404860
53ACVR1B0.76115683
54DAPK10.75212911
55BCR0.73835219
56ADRBK10.72959472
57MAPKAPK50.72650172
58ZAK0.69438176
59MAP3K70.67549994
60PASK0.67448754
61IKBKB0.63582283
62RPS6KB20.58504759
63CSNK1A1L0.57743341
64LYN0.55645698
65GRK50.52924866
66RPS6KA50.50059975
67TYRO30.48967624
68CCNB10.48613894
69EPHB20.47285171
70FYN0.44650925
71CSNK1G20.42760337
72CSNK1G10.42161402
73MAP2K30.41623098
74IKBKE0.40632417
75CAMKK10.40279909
76BRAF0.40161099
77STK100.39279824
78MAPKAPK20.38582320
79CDK90.38179812
80CSNK1A10.37395703
81MAPK130.37181678
82IGF1R0.32831169
83AKT30.32763630
84AURKA0.32647072
85PRKCA0.30122353
86INSR0.29866172
87CDK70.28906598
88BUB10.28830062
89DYRK20.28495682
90ATR0.26791233
91PRKACA0.26077986
92CAMK2A0.25160551
93INSRR0.25062497
94TAOK20.24925488
95PRKG10.23840045
96OBSCN0.22881787
97TNK20.22186333
98CAMK10.21210506
99DYRK1B0.20651388
100HCK0.20395826

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.17741661
2Antigen processing and presentation_Homo sapiens_hsa046123.63780016
3Autoimmune thyroid disease_Homo sapiens_hsa053203.46471846
4Allograft rejection_Homo sapiens_hsa053303.27955359
5Graft-versus-host disease_Homo sapiens_hsa053323.24299542
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.17320584
7Ribosome_Homo sapiens_hsa030102.84642990
8Type I diabetes mellitus_Homo sapiens_hsa049402.64790143
9Oxidative phosphorylation_Homo sapiens_hsa001902.64312349
10Asthma_Homo sapiens_hsa053102.62745788
11Proteasome_Homo sapiens_hsa030502.46402897
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.42282814
13Hematopoietic cell lineage_Homo sapiens_hsa046402.37755753
14Parkinsons disease_Homo sapiens_hsa050122.13948919
15Rheumatoid arthritis_Homo sapiens_hsa053232.12136208
16RNA polymerase_Homo sapiens_hsa030201.99533290
17T cell receptor signaling pathway_Homo sapiens_hsa046601.97041588
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92300104
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.60005387
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40423493
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39530388
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35226202
23Alzheimers disease_Homo sapiens_hsa050101.26979594
24Staphylococcus aureus infection_Homo sapiens_hsa051501.19876820
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18978425
26Viral myocarditis_Homo sapiens_hsa054161.14522353
27Phototransduction_Homo sapiens_hsa047441.14170054
28Peroxisome_Homo sapiens_hsa041461.13981028
29Cardiac muscle contraction_Homo sapiens_hsa042601.13788091
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.11733157
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11238727
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09459352
33Systemic lupus erythematosus_Homo sapiens_hsa053221.07802434
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07023216
35Huntingtons disease_Homo sapiens_hsa050161.06284405
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06273488
37Pyrimidine metabolism_Homo sapiens_hsa002400.97858597
38Protein export_Homo sapiens_hsa030600.91976116
39Linoleic acid metabolism_Homo sapiens_hsa005910.90824225
40Fanconi anemia pathway_Homo sapiens_hsa034600.83669425
41Arachidonic acid metabolism_Homo sapiens_hsa005900.82682702
42Basal transcription factors_Homo sapiens_hsa030220.77266454
43Measles_Homo sapiens_hsa051620.75977527
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72261675
45Homologous recombination_Homo sapiens_hsa034400.67962581
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67788132
47Malaria_Homo sapiens_hsa051440.67074918
48Leishmaniasis_Homo sapiens_hsa051400.66966573
49Purine metabolism_Homo sapiens_hsa002300.65835988
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62100638
51Herpes simplex infection_Homo sapiens_hsa051680.61707523
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59370983
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57056945
54Spliceosome_Homo sapiens_hsa030400.53683830
55RNA degradation_Homo sapiens_hsa030180.52884195
56Salmonella infection_Homo sapiens_hsa051320.52569439
57DNA replication_Homo sapiens_hsa030300.52561429
58Selenocompound metabolism_Homo sapiens_hsa004500.50686902
59Ether lipid metabolism_Homo sapiens_hsa005650.48368904
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48249988
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48104396
62Base excision repair_Homo sapiens_hsa034100.47681140
63Caffeine metabolism_Homo sapiens_hsa002320.46016856
64Nitrogen metabolism_Homo sapiens_hsa009100.45224442
65Epstein-Barr virus infection_Homo sapiens_hsa051690.44806845
66Butanoate metabolism_Homo sapiens_hsa006500.44528917
67Chemical carcinogenesis_Homo sapiens_hsa052040.44497754
68Tuberculosis_Homo sapiens_hsa051520.42286857
69HTLV-I infection_Homo sapiens_hsa051660.40951114
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40847895
71African trypanosomiasis_Homo sapiens_hsa051430.40179635
72Collecting duct acid secretion_Homo sapiens_hsa049660.40041763
73Nucleotide excision repair_Homo sapiens_hsa034200.39549095
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38972722
75Shigellosis_Homo sapiens_hsa051310.38853299
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36411026
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35791392
78Prion diseases_Homo sapiens_hsa050200.34583346
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33118603
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32808682
81Olfactory transduction_Homo sapiens_hsa047400.32256102
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30880249
83Sulfur metabolism_Homo sapiens_hsa009200.30311975
84Phagosome_Homo sapiens_hsa041450.30114802
85Influenza A_Homo sapiens_hsa051640.30034593
86Metabolic pathways_Homo sapiens_hsa011000.29570855
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28157910
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27442568
89Chemokine signaling pathway_Homo sapiens_hsa040620.26210549
90Vitamin digestion and absorption_Homo sapiens_hsa049770.24982599
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24420819
92N-Glycan biosynthesis_Homo sapiens_hsa005100.24419162
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24279426
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23324997
95Retinol metabolism_Homo sapiens_hsa008300.22933934
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22274051
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.17989866
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17761439
99Glycerolipid metabolism_Homo sapiens_hsa005610.17508322
100Fatty acid degradation_Homo sapiens_hsa000710.16807743

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