HSPB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.51609705
2sarcomere organization (GO:0045214)8.89048484
3actin-mediated cell contraction (GO:0070252)8.67438571
4myofibril assembly (GO:0030239)8.40050971
5cardiac muscle contraction (GO:0060048)7.43532754
6cardiac muscle tissue morphogenesis (GO:0055008)7.27240602
7heart contraction (GO:0060047)7.01510862
8heart process (GO:0003015)7.01510862
9cardiac muscle cell development (GO:0055013)6.75777810
10muscle tissue morphogenesis (GO:0060415)6.58010753
11cardiac muscle hypertrophy (GO:0003300)6.54206815
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.52821249
13response to muscle activity (GO:0014850)6.45138152
14ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.43745356
15cardiac cell development (GO:0055006)6.41281488
16actin filament-based movement (GO:0030048)6.39402674
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.32904930
18actomyosin structure organization (GO:0031032)6.29358140
19striated muscle hypertrophy (GO:0014897)6.20828511
20striated muscle contraction (GO:0006941)6.06728923
21regulation of skeletal muscle contraction (GO:0014819)6.00738782
22regulation of relaxation of muscle (GO:1901077)5.96587147
23muscle cell cellular homeostasis (GO:0046716)5.95922607
24negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.90910400
25ATP synthesis coupled proton transport (GO:0015986)5.85176516
26energy coupled proton transport, down electrochemical gradient (GO:0015985)5.85176516
27negative regulation of potassium ion transmembrane transport (GO:1901380)5.71502260
28skeletal muscle fiber development (GO:0048741)5.67537350
29adult heart development (GO:0007512)5.58810526
30muscle hypertrophy (GO:0014896)5.52137199
31tricarboxylic acid cycle (GO:0006099)5.46826864
32oxidative phosphorylation (GO:0006119)5.45647731
33negative regulation of striated muscle cell apoptotic process (GO:0010664)5.36514369
34regulation of sarcomere organization (GO:0060297)5.27514399
35regulation of actin filament-based movement (GO:1903115)5.19600741
36regulation of cardioblast differentiation (GO:0051890)5.15840047
37heart trabecula formation (GO:0060347)5.13351555
38myotube cell development (GO:0014904)5.12422410
39regulation of the force of heart contraction (GO:0002026)4.98415641
40regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.96887422
41skeletal muscle tissue development (GO:0007519)4.96143172
42plasma membrane repair (GO:0001778)4.78153178
43muscle cell fate commitment (GO:0042693)4.75361940
44striated muscle atrophy (GO:0014891)4.68948048
45positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.64103503
46regulation of striated muscle contraction (GO:0006942)4.63051139
47respiratory electron transport chain (GO:0022904)4.61319476
48myoblast fusion (GO:0007520)4.54451106
49cardiac muscle adaptation (GO:0014887)4.51806475
50cardiac muscle hypertrophy in response to stress (GO:0014898)4.51806475
51muscle hypertrophy in response to stress (GO:0003299)4.51806475
52electron transport chain (GO:0022900)4.50272082
53skeletal muscle adaptation (GO:0043501)4.47500074
54positive regulation of myotube differentiation (GO:0010831)4.45475605
55creatine metabolic process (GO:0006600)4.39919955
56regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.35464729
57ventricular cardiac muscle cell development (GO:0055015)4.34166862
58ventricular cardiac muscle cell action potential (GO:0086005)4.32743555
59bundle of His cell to Purkinje myocyte communication (GO:0086069)4.32170628
60response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.30845828
61muscle organ development (GO:0007517)4.24402656
62regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.19379223
63muscle structure development (GO:0061061)4.17694134
64regulation of striated muscle cell apoptotic process (GO:0010662)4.17351475
65muscle atrophy (GO:0014889)4.16898456
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.16208880
67sarcoplasmic reticulum calcium ion transport (GO:0070296)4.15805835
68negative regulation of protein localization to cell surface (GO:2000009)4.15253042
69regulation of ATPase activity (GO:0043462)4.12996165
70regulation of ATP catabolic process (GO:1903289)4.12996165
71positive regulation of myoblast differentiation (GO:0045663)4.12619033
72skeletal muscle tissue regeneration (GO:0043403)4.01251292
73striated muscle cell development (GO:0055002)3.96250604
74regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.94963731
75syncytium formation by plasma membrane fusion (GO:0000768)3.93888382
76response to inactivity (GO:0014854)3.93579189
77ATP biosynthetic process (GO:0006754)3.77233929
78regulation of cell communication by electrical coupling (GO:0010649)3.76494730
79regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.76467034
80NADH metabolic process (GO:0006734)3.74579880
81muscle contraction (GO:0006936)3.74258903
82skeletal muscle contraction (GO:0003009)3.73755275
83regulation of cardiac muscle cell apoptotic process (GO:0010665)3.72508358
84carnitine shuttle (GO:0006853)3.71868693
85glycogen biosynthetic process (GO:0005978)3.71739378
86glucan biosynthetic process (GO:0009250)3.71739378
87peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.69466188
88cytidine deamination (GO:0009972)3.62396781
89cytidine metabolic process (GO:0046087)3.62396781
90cytidine catabolic process (GO:0006216)3.62396781
91regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.59783797
92striated muscle tissue development (GO:0014706)3.58576645
93regulation of muscle contraction (GO:0006937)3.57372400
94regulation of membrane repolarization (GO:0060306)3.56325729
95cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55951725
96regulation of acyl-CoA biosynthetic process (GO:0050812)3.55368476
97outflow tract septum morphogenesis (GO:0003148)3.52199067
98negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.51567930
99muscle system process (GO:0003012)3.48429304
100trabecula formation (GO:0060343)3.47041118
101muscle cell development (GO:0055001)3.45740339
102regulation of coenzyme metabolic process (GO:0051196)3.41317411
103regulation of cofactor metabolic process (GO:0051193)3.41317411
104striated muscle adaptation (GO:0014888)3.39337961
105glycogen catabolic process (GO:0005980)3.36140315
106cardiac right ventricle morphogenesis (GO:0003215)3.34286132
107negative regulation of calcium ion transmembrane transport (GO:1903170)3.34009963
108negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.34009963
109regulation of heart rate (GO:0002027)3.33420116
110positive regulation of cardiac muscle tissue development (GO:0055025)3.32773254
111atrial septum morphogenesis (GO:0060413)3.31346930
112regulation of myoblast differentiation (GO:0045661)3.30668788
113positive regulation of cardiac muscle cell proliferation (GO:0060045)3.29771053
114muscle tissue development (GO:0060537)3.28549958
115cardiac chamber formation (GO:0003207)3.28542503
116pyrimidine ribonucleoside catabolic process (GO:0046133)3.28273578
117syncytium formation (GO:0006949)3.27212589
118negative regulation of nitric-oxide synthase activity (GO:0051001)3.25729915
119cardiac muscle cell action potential involved in contraction (GO:0086002)3.23739108
120regulation of calcium ion transmembrane transporter activity (GO:1901019)3.23314004
121regulation of calcium ion transmembrane transport (GO:1903169)3.23314004
122regulation of muscle system process (GO:0090257)3.19067955
123cardiac muscle tissue development (GO:0048738)3.18965449
124cardiac muscle cell action potential (GO:0086001)3.18447298
125cell migration involved in heart development (GO:0060973)3.17592011
126negative regulation of muscle hypertrophy (GO:0014741)3.15383930
127regulation of heart contraction (GO:0008016)3.13910994
128positive regulation of cardiac muscle tissue growth (GO:0055023)3.13081034
129regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.12495106
130muscle adaptation (GO:0043500)3.11803696
131glucan catabolic process (GO:0009251)3.10919819
132muscle fiber development (GO:0048747)3.10580059
133neuromuscular synaptic transmission (GO:0007274)3.09680888
134positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.09524343
135fatty acid transmembrane transport (GO:1902001)3.08494838
136cell communication involved in cardiac conduction (GO:0086065)3.08329479
137regulation of skeletal muscle cell differentiation (GO:2001014)3.07813322
138negative regulation of skeletal muscle tissue development (GO:0048642)3.04833399
139regulation of sequestering of triglyceride (GO:0010889)3.03446920
140response to activity (GO:0014823)3.00841656
141regulation of integrin-mediated signaling pathway (GO:2001044)2.99945848
142negative regulation of cardiac muscle tissue growth (GO:0055022)2.99130232
143negative regulation of heart growth (GO:0061117)2.99130232
144positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.90793943
145cellular polysaccharide catabolic process (GO:0044247)2.88579446
146musculoskeletal movement (GO:0050881)2.88166219
147multicellular organismal movement (GO:0050879)2.88166219
148muscle organ morphogenesis (GO:0048644)2.83149798
149muscle filament sliding (GO:0030049)10.2424315
150actin-myosin filament sliding (GO:0033275)10.2424315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse6.02453626
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.91392050
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.29447656
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.58896084
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.27604092
6TRIM28_21343339_ChIP-Seq_HEK293_Human4.16645265
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.15667267
8MEF2A_21415370_ChIP-Seq_HL-1_Mouse4.13932447
9TBX20_22328084_ChIP-Seq_HEART_Mouse3.73491792
10TBX20_22080862_ChIP-Seq_HEART_Mouse3.73491792
11ESR1_20079471_ChIP-ChIP_T-47D_Human3.62656253
12GATA4_21415370_ChIP-Seq_HL-1_Mouse3.27065749
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.07821119
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.83569282
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.78960694
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.75307677
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.57969533
18NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.42001626
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30978662
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.26144753
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.15254800
22EZH2_22144423_ChIP-Seq_EOC_Human2.13745419
23ISL1_27105846_Chip-Seq_CPCs_Mouse2.12767095
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06129638
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01587046
26GATA1_22025678_ChIP-Seq_K562_Human1.88051544
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86618433
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.84895170
29BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.81407127
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78125297
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77354729
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.77004106
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.69812781
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63699328
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63204986
36CLOCK_20551151_ChIP-Seq_293T_Human1.61741823
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61669358
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59963491
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59871053
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55603228
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55603228
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.52199791
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52069189
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48622875
45PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45867537
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44576084
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42204224
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41253797
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41253797
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38609067
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35683588
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.35503853
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34160079
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31725427
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30853740
56BRD4_25478319_ChIP-Seq_HGPS_Human1.30657208
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29963883
58ZNF274_21170338_ChIP-Seq_K562_Hela1.29717628
59* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29621689
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24725270
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21460274
62SMC1_22415368_ChIP-Seq_MEFs_Mouse1.20326330
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.20049868
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.19620311
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18766068
66* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18451674
67ZNF263_19887448_ChIP-Seq_K562_Human1.17414541
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.15776189
69RAD21_21589869_ChIP-Seq_MESCs_Mouse1.15518131
70TBX5_21415370_ChIP-Seq_HL-1_Mouse1.15490286
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.14839245
72TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12757030
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11394268
74SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10510558
75CJUN_26792858_Chip-Seq_BT549_Human1.09914640
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09612204
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07224693
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06036481
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05938104
80SA1_22415368_ChIP-Seq_MEFs_Mouse1.05653980
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.04957460
82PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04527607
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03712463
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02167572
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99773192
86ESR1_21235772_ChIP-Seq_MCF-7_Human0.98972730
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98699161
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97991253
89TP53_18474530_ChIP-ChIP_U2OS_Human0.97711296
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95685201
91SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93878496
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92776304
93GBX2_23144817_ChIP-Seq_PC3_Human0.92040851
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91540816
95PIAS1_25552417_ChIP-Seq_VCAP_Human0.90995121
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90935230
97GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90617531
98* TP53_23651856_ChIP-Seq_MEFs_Mouse0.90544505
99PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90527160
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.89730493
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88234379
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87118899
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87055362
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86713334
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86710737
106MYC_19829295_ChIP-Seq_ESCs_Human0.86324072
107OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86181190
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85493644
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85407714
110JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85157948
111SPI1_20517297_ChIP-Seq_HL60_Human0.85043771
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84323151
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84191524
114THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84040549
115RNF2_27304074_Chip-Seq_ESCs_Mouse0.83761725
116JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.83122852
117STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.83052788
118* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82836872
119NELFA_20434984_ChIP-Seq_ESCs_Mouse0.82511198
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82348407
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82198583
122AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81968987
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.81359315
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.80764460
125DROSHA_22980978_ChIP-Seq_HELA_Human0.79880534
126ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79625602
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.78845627
128RXR_22158963_ChIP-Seq_LIVER_Mouse0.78414266
129E2F1_18555785_ChIP-Seq_MESCs_Mouse0.78229672
130* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78208288
131MYC_27129775_Chip-Seq_CORNEA_Mouse0.77919235
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77894845
133MYC_18555785_ChIP-Seq_MESCs_Mouse0.77456045
134SOX17_20123909_ChIP-Seq_XEN_Mouse0.77032576
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76760166
136MYC_19030024_ChIP-ChIP_MESCs_Mouse0.76698448
137PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76182561
138* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.75530103
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75283232
140YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.75260396
141EST1_17652178_ChIP-ChIP_JURKAT_Human0.73060524
142ETS1_20019798_ChIP-Seq_JURKAT_Human0.71301644
143CTCF_27219007_Chip-Seq_Bcells_Human0.71058803
144OCT4_20526341_ChIP-Seq_ESCs_Human0.70416556
145BCAT_22108803_ChIP-Seq_LS180_Human0.69404621
146CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.66850126
147MYC_18358816_ChIP-ChIP_MESCs_Mouse0.65467150
148NANOG_18555785_ChIP-Seq_MESCs_Mouse0.64459131
149ATF3_27146783_Chip-Seq_COLON_Human0.64300799
150EOMES_21245162_ChIP-Seq_HESCs_Human0.63327077
151TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.63009386
152NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.62681602
153PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.62380227
154TP63_22573176_ChIP-Seq_HFKS_Human0.62307810
155NANOG_16153702_ChIP-ChIP_HESCs_Human0.61895169
156NFI_21473784_ChIP-Seq_ESCs_Mouse0.61436072
157RACK7_27058665_Chip-Seq_MCF-7_Human0.61075217
158TDRD3_21172665_ChIP-Seq_MCF-7_Human0.60108623
159NR3C1_23031785_ChIP-Seq_PC12_Mouse0.57227912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.05626249
2MP0002837_dystrophic_cardiac_calcinosis4.97678101
3* MP0000749_muscle_degeneration4.73938353
4MP0004036_abnormal_muscle_relaxation4.59303090
5MP0000751_myopathy4.31556941
6MP0003646_muscle_fatigue4.14897147
7MP0005330_cardiomyopathy3.90587410
8MP0004215_abnormal_myocardial_fiber3.86339080
9MP0002972_abnormal_cardiac_muscle3.53506085
10* MP0004087_abnormal_muscle_fiber3.16302508
11MP0004145_abnormal_muscle_electrophysio3.13045093
12MP0008775_abnormal_heart_ventricle3.07450665
13MP0005620_abnormal_muscle_contractility3.04363876
14MP0010630_abnormal_cardiac_muscle2.81586177
15MP0006138_congestive_heart_failure2.69077570
16MP0003221_abnormal_cardiomyocyte_apopto2.67519961
17MP0001544_abnormal_cardiovascular_syste2.65274698
18MP0005385_cardiovascular_system_phenoty2.65274698
19MP0002106_abnormal_muscle_physiology2.63705793
20MP0003137_abnormal_impulse_conducting2.61508060
21MP0003828_pulmonary_edema2.56863417
22MP0000750_abnormal_muscle_regeneration2.33343788
23MP0004484_altered_response_of2.28304769
24MP0003950_abnormal_plasma_membrane2.27182010
25MP0004085_abnormal_heartbeat2.26809485
26MP0004510_myositis2.25980252
27MP0002127_abnormal_cardiovascular_syste2.21902075
28* MP0002269_muscular_atrophy2.15748702
29MP0005369_muscle_phenotype2.15262865
30MP0004270_analgesia2.02373774
31MP0005451_abnormal_body_composition2.02213047
32* MP0000759_abnormal_skeletal_muscle1.89670979
33MP0006036_abnormal_mitochondrial_physio1.84909260
34MP0003567_abnormal_fetal_cardiomyocyte1.83139464
35MP0004233_abnormal_muscle_weight1.77599469
36MP0003011_delayed_dark_adaptation1.75559946
37MP0000013_abnormal_adipose_tissue1.71440521
38* MP0000747_muscle_weakness1.59799379
39MP0003122_maternal_imprinting1.56804861
40MP0009780_abnormal_chondrocyte_physiolo1.52920867
41MP0001958_emphysema1.48497408
42MP0004130_abnormal_muscle_cell1.46009628
43MP0002332_abnormal_exercise_endurance1.42595804
44MP0004272_abnormal_basement_membrane1.39020836
45MP0001542_abnormal_bone_strength1.37187508
46MP0001299_abnormal_eye_distance/1.35978882
47MP0000266_abnormal_heart_morphology1.30576608
48MP0003279_aneurysm1.30204367
49MP0009384_cardiac_valve_regurgitation1.28686948
50MP0002971_abnormal_brown_adipose1.26113620
51MP0003806_abnormal_nucleotide_metabolis1.14269968
52MP0000003_abnormal_adipose_tissue1.10885603
53MP0000372_irregular_coat_pigmentation1.03877378
54MP0006035_abnormal_mitochondrial_morpho1.02601039
55MP0005375_adipose_tissue_phenotype1.02497682
56MP0005171_absent_coat_pigmentation0.97416785
57MP0003941_abnormal_skin_development0.94572441
58MP0003566_abnormal_cell_adhesion0.91832169
59MP0000230_abnormal_systemic_arterial0.90303002
60MP0000343_altered_response_to0.90076534
61MP0002128_abnormal_blood_circulation0.89585993
62MP0000767_abnormal_smooth_muscle0.89477682
63MP0010368_abnormal_lymphatic_system0.88842514
64MP0003123_paternal_imprinting0.88275710
65MP0001661_extended_life_span0.86218539
66MP0005623_abnormal_meninges_morphology0.81188496
67MP0005266_abnormal_metabolism0.79193843
68MP0002108_abnormal_muscle_morphology0.79077793
69MP0003121_genomic_imprinting0.78918874
70MP0002088_abnormal_embryonic_growth/wei0.77958769
71MP0002295_abnormal_pulmonary_circulatio0.77907162
72MP0003984_embryonic_growth_retardation0.77146862
73MP0004134_abnormal_chest_morphology0.76497289
74MP0000733_abnormal_muscle_development0.74732103
75MP0008438_abnormal_cutaneous_collagen0.72852334
76MP0002234_abnormal_pharynx_morphology0.72130112
77MP0002925_abnormal_cardiovascular_devel0.72001785
78MP0001879_abnormal_lymphatic_vessel0.70430991
79MP0002896_abnormal_bone_mineralization0.68907583
80MP0005165_increased_susceptibility_to0.68611446
81MP0000537_abnormal_urethra_morphology0.66880021
82MP0005670_abnormal_white_adipose0.63028973
83MP0003045_fibrosis0.62395877
84MP0003705_abnormal_hypodermis_morpholog0.61727273
85MP0005666_abnormal_adipose_tissue0.60534964
86MP0005508_abnormal_skeleton_morphology0.58779373
87MP0003385_abnormal_body_wall0.58156583
88MP0001784_abnormal_fluid_regulation0.56505961
89MP0001614_abnormal_blood_vessel0.55915794
90MP0005503_abnormal_tendon_morphology0.54795794
91MP0003115_abnormal_respiratory_system0.54561946
92MP0002734_abnormal_mechanical_nocicepti0.53519542
93MP0005380_embryogenesis_phenotype0.52130595
94MP0001672_abnormal_embryogenesis/_devel0.52130595
95* MP0002114_abnormal_axial_skeleton0.51294590
96MP0009697_abnormal_copulation0.47465193
97MP0003959_abnormal_lean_body0.47088605
98MP0005377_hearing/vestibular/ear_phenot0.47073094
99MP0003878_abnormal_ear_physiology0.47073094
100MP0005023_abnormal_wound_healing0.47054554
101MP0005595_abnormal_vascular_smooth0.47045124
102MP0003091_abnormal_cell_migration0.46595271
103MP0001730_embryonic_growth_arrest0.45268566
104MP0008569_lethality_at_weaning0.44791284
105MP0002133_abnormal_respiratory_system0.43767262
106MP0005388_respiratory_system_phenotype0.43767262
107MP0003879_abnormal_hair_cell0.42838466
108MP0005275_abnormal_skin_tensile0.42290863
109MP0000516_abnormal_urinary_system0.41658359
110MP0005367_renal/urinary_system_phenotyp0.41658359
111* MP0000762_abnormal_tongue_morphology0.40982652
112MP0003948_abnormal_gas_homeostasis0.40683888
113MP0002282_abnormal_trachea_morphology0.40410222
114MP0001175_abnormal_lung_morphology0.39283241
115MP0003942_abnormal_urinary_system0.38679516
116MP0005257_abnormal_intraocular_pressure0.38622960
117MP0004858_abnormal_nervous_system0.37374361
118MP0005423_abnormal_somatic_nervous0.36622426
119MP0001697_abnormal_embryo_size0.36426745
120MP0004185_abnormal_adipocyte_glucose0.36135948
121MP0009250_abnormal_appendicular_skeleto0.35892890
122MP0004883_abnormal_blood_vessel0.34888158
123MP0006054_spinal_hemorrhage0.34847103
124MP0004133_heterotaxia0.34492576
125* MP0005452_abnormal_adipose_tissue0.33181395
126MP0002249_abnormal_larynx_morphology0.32651651
127MP0000163_abnormal_cartilage_morphology0.32270539
128MP0002086_abnormal_extraembryonic_tissu0.31809114
129MP0003191_abnormal_cellular_cholesterol0.30780869
130MP0009672_abnormal_birth_weight0.30697467
131MP0002638_abnormal_pupillary_reflex0.30121935
132MP0003119_abnormal_digestive_system0.28921304
133MP0010030_abnormal_orbit_morphology0.28829799
134MP0005376_homeostasis/metabolism_phenot0.28114309

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)7.63575145
2Sudden death (HP:0001699)7.06722627
3Calf muscle hypertrophy (HP:0008981)6.96248195
4Exercise-induced myalgia (HP:0003738)6.50813601
5Muscle hypertrophy of the lower extremities (HP:0008968)6.43478086
6Ventricular tachycardia (HP:0004756)6.07776689
7Popliteal pterygium (HP:0009756)5.65526078
8Atrial fibrillation (HP:0005110)5.53171992
9Abnormality of the left ventricular outflow tract (HP:0011103)5.34164420
10Subaortic stenosis (HP:0001682)5.34164420
11Lipoatrophy (HP:0100578)5.32420254
12Abnormality of the calf musculature (HP:0001430)5.26623765
13Primary atrial arrhythmia (HP:0001692)5.13646891
14Ulnar deviation of the wrist (HP:0003049)5.10608286
15Supraventricular tachycardia (HP:0004755)4.99412979
16Hyporeflexia of lower limbs (HP:0002600)4.93806458
17Type 2 muscle fiber atrophy (HP:0003554)4.92883625
18Supraventricular arrhythmia (HP:0005115)4.89550260
19Myoglobinuria (HP:0002913)4.84288039
20Muscle fiber atrophy (HP:0100295)4.48036402
21EMG: myopathic abnormalities (HP:0003458)4.46872910
22Muscle fiber splitting (HP:0003555)4.43071804
23Fatigable weakness (HP:0003473)4.41117949
24Abnormality of the neuromuscular junction (HP:0003398)4.41117949
25Fetal akinesia sequence (HP:0001989)4.39291811
26Calcaneovalgus deformity (HP:0001848)4.37436231
27Malignant hyperthermia (HP:0002047)4.33605749
28Weak cry (HP:0001612)4.32136485
29Abnormality of placental membranes (HP:0011409)4.31885307
30Amniotic constriction ring (HP:0009775)4.31885307
31Dilated cardiomyopathy (HP:0001644)4.23519147
32Rhabdomyolysis (HP:0003201)4.16140747
33Right ventricular cardiomyopathy (HP:0011663)4.05983016
34Gowers sign (HP:0003391)4.00793257
35Myopathic facies (HP:0002058)3.99594441
36Deformed tarsal bones (HP:0008119)3.95723997
37Type 1 muscle fiber predominance (HP:0003803)3.93296731
38Absent phalangeal crease (HP:0006109)3.89055073
39Palpitations (HP:0001962)3.79606195
40Prolonged QT interval (HP:0001657)3.72203353
41Ventricular arrhythmia (HP:0004308)3.71155928
42Aplasia of the musculature (HP:0100854)3.69903286
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.67901889
44Muscle fiber inclusion bodies (HP:0100299)3.64331922
45Syncope (HP:0001279)3.63577638
46Acute necrotizing encephalopathy (HP:0006965)3.52872242
47Asymmetric septal hypertrophy (HP:0001670)3.48160888
48Abnormal mitochondria in muscle tissue (HP:0008316)3.38606167
49Nemaline bodies (HP:0003798)3.34146866
50Distal lower limb muscle weakness (HP:0009053)3.30767015
51Abnormal finger flexion creases (HP:0006143)3.15836493
52Bundle branch block (HP:0011710)3.09123825
53Neck muscle weakness (HP:0000467)3.08526605
54Centrally nucleated skeletal muscle fibers (HP:0003687)3.06159224
55Increased connective tissue (HP:0009025)3.05740330
56Easy fatigability (HP:0003388)3.04636608
57Double outlet right ventricle (HP:0001719)3.00088097
58Congenital malformation of the right heart (HP:0011723)3.00088097
59Exercise intolerance (HP:0003546)2.97120007
60Bulbar palsy (HP:0001283)2.93665801
61Ragged-red muscle fibers (HP:0003200)2.91038891
62Hepatic necrosis (HP:0002605)2.90959741
63Left ventricular hypertrophy (HP:0001712)2.89123262
64Heart block (HP:0012722)2.87104236
65Myotonia (HP:0002486)2.86919600
66Progressive macrocephaly (HP:0004481)2.85800684
67Acute encephalopathy (HP:0006846)2.84778011
68Mitochondrial inheritance (HP:0001427)2.84650906
69Increased serum pyruvate (HP:0003542)2.84154853
70Abnormality of glycolysis (HP:0004366)2.84154853
71Increased CSF lactate (HP:0002490)2.75009216
72Abnormal atrioventricular conduction (HP:0005150)2.72680076
73Thin ribs (HP:0000883)2.71139420
74Conjunctival hamartoma (HP:0100780)2.68519964
75Abnormal EKG (HP:0003115)2.68010518
76Rimmed vacuoles (HP:0003805)2.66766005
77Pterygium (HP:0001059)2.65774203
78Muscle stiffness (HP:0003552)2.64744501
79Hypoplastic left heart (HP:0004383)2.64602967
80Respiratory insufficiency due to muscle weakness (HP:0002747)2.63994102
81Palmoplantar keratoderma (HP:0000982)2.63503235
82Areflexia of lower limbs (HP:0002522)2.61290796
83Atrioventricular block (HP:0001678)2.57919888
84Difficulty running (HP:0009046)2.54635741
85Hepatocellular necrosis (HP:0001404)2.53544604
86Nonprogressive disorder (HP:0003680)2.52447197
87Generalized muscle weakness (HP:0003324)2.51141215
88Ventricular fibrillation (HP:0001663)2.49824815
89Hip contracture (HP:0003273)2.48153409
90Hypoplastic heart (HP:0001961)2.43320344
91Patent foramen ovale (HP:0001655)2.42820002
92Pheochromocytoma (HP:0002666)2.42324532
93Slender build (HP:0001533)2.40446067
94Akinesia (HP:0002304)2.40123604
95Abnormality of the calcaneus (HP:0008364)2.38980617
96Spinal rigidity (HP:0003306)2.36296501
97Aortic aneurysm (HP:0004942)2.35764995
98Cerebral edema (HP:0002181)2.33938683
99Neoplasm of the adrenal gland (HP:0100631)2.33445962
100Scapular winging (HP:0003691)2.31603692
101Frequent falls (HP:0002359)2.31101864
102Abnormality of the foot musculature (HP:0001436)2.29106460
103Limb-girdle muscle atrophy (HP:0003797)2.28863797
104EMG: neuropathic changes (HP:0003445)2.26371752
105Neuroendocrine neoplasm (HP:0100634)2.23349102
106Protrusio acetabuli (HP:0003179)2.23121147
107Mildly elevated creatine phosphokinase (HP:0008180)2.15229937
108Diaphragmatic weakness (HP:0009113)2.12650125
109Hypoglycemic coma (HP:0001325)2.09499033
110Steppage gait (HP:0003376)2.09060194
111Respiratory failure (HP:0002878)2.06356044
112Foot dorsiflexor weakness (HP:0009027)2.05505020
113Pulmonary artery stenosis (HP:0004415)2.04919067
114Lactic acidosis (HP:0003128)2.02437345
115Distal arthrogryposis (HP:0005684)2.02374537
116Metatarsus adductus (HP:0001840)2.01875313
117Abnormality of skeletal muscle fiber size (HP:0012084)1.98475205
118Increased muscle lipid content (HP:0009058)1.97844613
119Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95098606
120Difficulty climbing stairs (HP:0003551)1.94620514
121Round ear (HP:0100830)1.94395621
122Lipid accumulation in hepatocytes (HP:0006561)1.93708862
123Increased intramyocellular lipid droplets (HP:0012240)1.93090984
124Long clavicles (HP:0000890)1.92031326
125Limited hip movement (HP:0008800)1.91259677
126Increased variability in muscle fiber diameter (HP:0003557)1.91185466
127Congestive heart failure (HP:0001635)1.89843941
128Periauricular skin pits (HP:0100277)1.89057933
129Preauricular pit (HP:0004467)1.89057933
130Limb-girdle muscle weakness (HP:0003325)1.86603119
131Waddling gait (HP:0002515)1.84382435
132Increased hepatocellular lipid droplets (HP:0006565)1.84193774
133Aplasia/Hypoplasia involving the musculature (HP:0001460)1.84059492
134Generalized amyotrophy (HP:0003700)1.80954881
135Abnormal ventriculo-arterial connection (HP:0011563)1.80120514
136Transposition of the great arteries (HP:0001669)1.80120514
137Abnormal connection of the cardiac segments (HP:0011545)1.80120514
138Muscular dystrophy (HP:0003560)1.78782175
139Abnormality of the shoulder girdle musculature (HP:0001435)1.75798794
140Cystic hygroma (HP:0000476)1.75515756
141Abnormality of urine glucose concentration (HP:0011016)1.75145400
142Glycosuria (HP:0003076)1.75145400
143Dicarboxylic aciduria (HP:0003215)1.73947793
144Breech presentation (HP:0001623)1.73879396
145Distal lower limb amyotrophy (HP:0008944)1.73500358
146Aortic dissection (HP:0002647)1.69202953
147Delayed gross motor development (HP:0002194)1.66289282
148Proximal amyotrophy (HP:0007126)1.64453137
149Webbed neck (HP:0000465)1.59827105
150Premature rupture of membranes (HP:0001788)1.59410331
151Decreased muscle mass (HP:0003199)1.56660889
152Facial diplegia (HP:0001349)1.55962449
153Abnormalities of placenta or umbilical cord (HP:0001194)1.55190093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN9.11092162
2MYLK5.49526397
3TTN3.83094977
4ZAK3.46088503
5STK243.26842141
6PIK3CA2.93577430
7PKN22.60959367
8STK38L2.51848002
9PHKG22.46287008
10PHKG12.46287008
11DMPK2.35695589
12BCKDK2.05530270
13MUSK2.01361975
14PDK31.91927995
15PDK41.91927995
16NEK11.78319813
17LIMK11.73215343
18CDC42BPA1.69987677
19DDR21.65096242
20ILK1.63401037
21LMTK21.54898922
22MAP3K121.47698433
23TRPM71.41926110
24CCNB11.29244974
25DAPK31.22572695
26TRIB31.22120273
27TIE11.21767776
28PINK11.20904294
29TESK11.13259419
30MARK11.12627159
31PAK31.11682487
32ROCK11.08254659
33PDK21.07320387
34MAP2K31.04903923
35STK40.91320066
36FLT30.88920898
37MAP3K30.87892180
38MAPK70.85265706
39CAMK2D0.84567069
40PIK3CG0.81450243
41PAK60.80422422
42NME10.80031478
43EEF2K0.77016635
44MAP3K130.76720332
45MAPK120.76563502
46PRKD10.76141976
47PTK2B0.71226508
48KSR20.70710136
49WNK40.69489068
50PRKD30.68178745
51MAP3K70.68041589
52MAP3K50.65689747
53PAK20.63802467
54NUAK10.61973433
55ERBB30.61171942
56CAMK2B0.60747889
57MAPK40.60627354
58CAMK10.58064784
59PKN10.57772582
60GRK70.56479086
61PRKAA20.56064361
62PRKAA10.53036370
63MAP3K90.53018421
64ROCK20.51810062
65BRSK20.49596036
66LATS20.48853337
67AKT20.48415479
68EPHB20.47356555
69PAK40.47174122
70MAPKAPK30.46956645
71PRKACB0.46744292
72MAPK110.45476740
73RPS6KC10.44930632
74RPS6KL10.44930632
75STK30.44704269
76MARK30.44326502
77ABL20.43977792
78MAP2K40.42402433
79AKT30.41068459
80CAMK2A0.39952010
81DAPK20.39452269
82PLK40.39449119
83STK390.39193892
84PRKG10.39191583
85INSRR0.38050547
86KDR0.36129066
87CAMK2G0.35371952
88FGFR10.34891489
89NME20.34723200
90RPS6KA60.34373691
91PRKACA0.33719604
92PRKG20.33183940
93NEK90.33177001
94GRK50.32090291
95STK160.31850770
96PTK20.31326354
97SIK10.30547232
98EIF2AK30.30491857
99DYRK1B0.28622548
100PRKD20.27172442
101TGFBR20.25748759
102SGK30.25698017
103MAP3K100.25538701
104RIPK10.25193300
105LATS10.24461675
106WNK10.23785253
107STK380.23770961
108BRAF0.21724772
109RPS6KA30.21168642
110PRKCE0.20927880
111BRSK10.20306072
112MAP3K110.19706507
113LRRK20.18618768
114BCR0.18484981
115MAPKAPK20.18414607
116MAPK100.18362574
117MOS0.16719360
118AURKB0.16711099
119PDGFRA0.16510612
120GSK3A0.15868241
121PAK10.15568962
122PLK20.15209767
123MELK0.14945228
124ADRBK10.14692729
125PRKACG0.14668482
126CAMK40.14517037
127TBK10.14126051
128MAP2K10.14047246
129SGK20.13957875
130MAPK130.13387551
131CDK80.13351985
132CDK40.11685537
133MAP2K60.09242199
134RPS6KA10.08952464
135RAF10.08439268
136ARAF0.08423876

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042605.71844236
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.44486987
3Parkinsons disease_Homo sapiens_hsa050124.32711240
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.20033434
5Oxidative phosphorylation_Homo sapiens_hsa001904.19361570
6Dilated cardiomyopathy_Homo sapiens_hsa054143.95538341
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.41767337
8Alzheimers disease_Homo sapiens_hsa050103.03220173
9Huntingtons disease_Homo sapiens_hsa050162.93254154
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.61096704
11Carbon metabolism_Homo sapiens_hsa012002.57700550
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.39044869
13Propanoate metabolism_Homo sapiens_hsa006402.27353473
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.15752236
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.13355527
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.90736859
17Biosynthesis of amino acids_Homo sapiens_hsa012301.67719020
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62235884
19Pyruvate metabolism_Homo sapiens_hsa006201.61543490
20Fatty acid degradation_Homo sapiens_hsa000711.54383774
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37929244
22Galactose metabolism_Homo sapiens_hsa000521.27875981
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26428269
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26060085
25Tight junction_Homo sapiens_hsa045301.16606622
26Fatty acid metabolism_Homo sapiens_hsa012121.15309298
27Fructose and mannose metabolism_Homo sapiens_hsa000511.14043570
28HIF-1 signaling pathway_Homo sapiens_hsa040661.11061954
29Viral myocarditis_Homo sapiens_hsa054161.09134302
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08261970
31Arginine biosynthesis_Homo sapiens_hsa002201.05087338
32Starch and sucrose metabolism_Homo sapiens_hsa005001.03234802
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02258864
34Glucagon signaling pathway_Homo sapiens_hsa049221.00611784
35Central carbon metabolism in cancer_Homo sapiens_hsa052300.95489062
36Proteasome_Homo sapiens_hsa030500.94916909
37Focal adhesion_Homo sapiens_hsa045100.92061379
38Gastric acid secretion_Homo sapiens_hsa049710.89628269
39Long-term potentiation_Homo sapiens_hsa047200.84271958
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81572455
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77348544
42Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76753108
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.76006617
44Fatty acid elongation_Homo sapiens_hsa000620.73878809
45Phenylalanine metabolism_Homo sapiens_hsa003600.70008904
46Nitrogen metabolism_Homo sapiens_hsa009100.63928806
47Salivary secretion_Homo sapiens_hsa049700.62791306
48Insulin resistance_Homo sapiens_hsa049310.62171160
49Gap junction_Homo sapiens_hsa045400.60705613
50Oxytocin signaling pathway_Homo sapiens_hsa049210.60387286
51Insulin signaling pathway_Homo sapiens_hsa049100.59108597
52Calcium signaling pathway_Homo sapiens_hsa040200.58146972
53Adherens junction_Homo sapiens_hsa045200.57459035
54GnRH signaling pathway_Homo sapiens_hsa049120.57446945
55Insulin secretion_Homo sapiens_hsa049110.55800793
56ECM-receptor interaction_Homo sapiens_hsa045120.52255914
57Protein digestion and absorption_Homo sapiens_hsa049740.52001643
58Tyrosine metabolism_Homo sapiens_hsa003500.49948526
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49019599
60Hippo signaling pathway_Homo sapiens_hsa043900.47001420
61Mineral absorption_Homo sapiens_hsa049780.45301153
62Metabolic pathways_Homo sapiens_hsa011000.45111372
63Basal cell carcinoma_Homo sapiens_hsa052170.44456452
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.44385763
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42653237
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41312725
67Butanoate metabolism_Homo sapiens_hsa006500.40509109
68Amphetamine addiction_Homo sapiens_hsa050310.40016708
69Pentose phosphate pathway_Homo sapiens_hsa000300.39993267
70Cholinergic synapse_Homo sapiens_hsa047250.39849581
71Phototransduction_Homo sapiens_hsa047440.39615534
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38844820
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.37952411
74MAPK signaling pathway_Homo sapiens_hsa040100.37926775
75Glioma_Homo sapiens_hsa052140.37148361
76Arginine and proline metabolism_Homo sapiens_hsa003300.36426442
77PPAR signaling pathway_Homo sapiens_hsa033200.36359813
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35894140
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34608339
80Sulfur relay system_Homo sapiens_hsa041220.34396716
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.33785621
82TGF-beta signaling pathway_Homo sapiens_hsa043500.33767278
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33605271
84AMPK signaling pathway_Homo sapiens_hsa041520.32872917
85GABAergic synapse_Homo sapiens_hsa047270.32601710
86Histidine metabolism_Homo sapiens_hsa003400.31764216
87Ribosome_Homo sapiens_hsa030100.30838955
88RNA degradation_Homo sapiens_hsa030180.30567399
89Melanoma_Homo sapiens_hsa052180.29215224
90Long-term depression_Homo sapiens_hsa047300.28307111
91Folate biosynthesis_Homo sapiens_hsa007900.27796641
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27433156
93Dopaminergic synapse_Homo sapiens_hsa047280.27120145
94Purine metabolism_Homo sapiens_hsa002300.26959375
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.25426540
96Hedgehog signaling pathway_Homo sapiens_hsa043400.25415874
97Glutathione metabolism_Homo sapiens_hsa004800.24618570
98Pancreatic secretion_Homo sapiens_hsa049720.22776547
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21495859
100Lysine degradation_Homo sapiens_hsa003100.21485048
101beta-Alanine metabolism_Homo sapiens_hsa004100.21423017
102RNA polymerase_Homo sapiens_hsa030200.20699421
103* Proteoglycans in cancer_Homo sapiens_hsa052050.18080396
104Amoebiasis_Homo sapiens_hsa051460.17575230
105Peroxisome_Homo sapiens_hsa041460.17141860
106Arachidonic acid metabolism_Homo sapiens_hsa005900.16488023
107Melanogenesis_Homo sapiens_hsa049160.14159309
108Tryptophan metabolism_Homo sapiens_hsa003800.13545862
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.13421496
110Circadian rhythm_Homo sapiens_hsa047100.11953482
111cAMP signaling pathway_Homo sapiens_hsa040240.10891762
112Oocyte meiosis_Homo sapiens_hsa041140.10142452
113Type II diabetes mellitus_Homo sapiens_hsa049300.09331010
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09190816
115Wnt signaling pathway_Homo sapiens_hsa043100.08782720
116Sulfur metabolism_Homo sapiens_hsa009200.08646484
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.08315287
118Small cell lung cancer_Homo sapiens_hsa052220.06312295
119Mismatch repair_Homo sapiens_hsa034300.06265837
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06226385
121HTLV-I infection_Homo sapiens_hsa051660.05443759
122Pathways in cancer_Homo sapiens_hsa052000.04362422
123Circadian entrainment_Homo sapiens_hsa047130.03402965
124FoxO signaling pathway_Homo sapiens_hsa040680.02028498
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.01775728
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.00862032
127Pyrimidine metabolism_Homo sapiens_hsa002400.00637038
128Renin secretion_Homo sapiens_hsa049240.00365833
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0384816
130Protein export_Homo sapiens_hsa03060-0.0348321
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0283730
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0057649

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