HSPB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a muscle-specific small heat shock protein. A mutation in this gene is the cause of autosomal dominant distal hereditary motor neuropathy type 2C. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)8.59701708
2actin-mediated cell contraction (GO:0070252)8.49727020
3myofibril assembly (GO:0030239)8.10327018
4sarcomere organization (GO:0045214)7.67831213
5cardiac muscle contraction (GO:0060048)6.52697418
6heart process (GO:0003015)6.43127278
7heart contraction (GO:0060047)6.43127278
8regulation of skeletal muscle contraction (GO:0014819)6.34166359
9cardiac muscle hypertrophy (GO:0003300)6.22960382
10actin filament-based movement (GO:0030048)6.19699314
11striated muscle contraction (GO:0006941)6.13587371
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.05583007
13striated muscle hypertrophy (GO:0014897)5.94961304
14cardiac muscle tissue morphogenesis (GO:0055008)5.87130658
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.83019323
16actomyosin structure organization (GO:0031032)5.68399712
17regulation of sarcomere organization (GO:0060297)5.65235468
18energy coupled proton transport, down electrochemical gradient (GO:0015985)5.64247004
19ATP synthesis coupled proton transport (GO:0015986)5.64247004
20regulation of relaxation of muscle (GO:1901077)5.55917039
21cardiac muscle cell development (GO:0055013)5.54053859
22response to muscle activity (GO:0014850)5.42904981
23muscle tissue morphogenesis (GO:0060415)5.35377801
24skeletal muscle contraction (GO:0003009)5.28657069
25tricarboxylic acid cycle (GO:0006099)5.26074507
26positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.25789778
27muscle hypertrophy (GO:0014896)5.25046011
28cardiac cell development (GO:0055006)5.18200713
29sarcoplasmic reticulum calcium ion transport (GO:0070296)5.17101365
30regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.15818352
31striated muscle atrophy (GO:0014891)4.91632656
32ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.86661551
33negative regulation of potassium ion transmembrane transport (GO:1901380)4.79190377
34respiratory electron transport chain (GO:0022904)4.75057172
35oxidative phosphorylation (GO:0006119)4.72799315
36regulation of actin filament-based movement (GO:1903115)4.70790705
37regulation of cell communication by electrical coupling (GO:0010649)4.69380838
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.67158516
39electron transport chain (GO:0022900)4.64682231
40cardiac muscle hypertrophy in response to stress (GO:0014898)4.53901700
41muscle hypertrophy in response to stress (GO:0003299)4.53901700
42cardiac muscle adaptation (GO:0014887)4.53901700
43adult heart development (GO:0007512)4.53769298
44plasma membrane repair (GO:0001778)4.50562849
45regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.48333156
46muscle cell fate commitment (GO:0042693)4.46819711
47response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.45566141
48negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.36993808
49regulation of acyl-CoA biosynthetic process (GO:0050812)4.35798179
50muscle atrophy (GO:0014889)4.34120404
51regulation of striated muscle contraction (GO:0006942)4.32830624
52positive regulation of myotube differentiation (GO:0010831)4.26251618
53negative regulation of striated muscle cell apoptotic process (GO:0010664)4.21119866
54negative regulation of protein localization to cell surface (GO:2000009)4.17879189
55regulation of the force of heart contraction (GO:0002026)4.15993094
56regulation of cardiac muscle contraction (GO:0055117)4.07091748
57regulation of cofactor metabolic process (GO:0051193)4.06903421
58regulation of coenzyme metabolic process (GO:0051196)4.06903421
59regulation of cardiac muscle cell contraction (GO:0086004)4.05511752
60regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.04250900
61skeletal muscle tissue development (GO:0007519)4.01397840
62regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.96738368
63heart trabecula formation (GO:0060347)3.96311848
64regulation of heart rate (GO:0002027)3.95735847
65cell communication involved in cardiac conduction (GO:0086065)3.93231241
66skeletal muscle adaptation (GO:0043501)3.89144933
67response to inactivity (GO:0014854)3.89060161
68muscle contraction (GO:0006936)3.87286926
69negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.86546684
70regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.81816471
71striated muscle cell development (GO:0055002)3.80401477
72negative regulation of potassium ion transport (GO:0043267)3.78648845
73positive regulation of cardiac muscle cell differentiation (GO:2000727)3.75154365
74regulation of calcium ion transmembrane transport (GO:1903169)3.74311517
75regulation of calcium ion transmembrane transporter activity (GO:1901019)3.74311517
76negative regulation of nitric-oxide synthase activity (GO:0051001)3.70981097
77creatine metabolic process (GO:0006600)3.69140602
78mitochondrial genome maintenance (GO:0000002)3.68582884
79cardiac muscle cell action potential (GO:0086001)3.67111167
80skeletal muscle fiber development (GO:0048741)3.66823446
81positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.66585710
82striated muscle adaptation (GO:0014888)3.65017486
83regulation of cardioblast differentiation (GO:0051890)3.64845472
84muscle fiber development (GO:0048747)3.63248211
85muscle adaptation (GO:0043500)3.61763404
86cytidine deamination (GO:0009972)3.60707449
87cytidine metabolic process (GO:0046087)3.60707449
88cytidine catabolic process (GO:0006216)3.60707449
89muscle organ development (GO:0007517)3.59547165
90ATP biosynthetic process (GO:0006754)3.58409163
91muscle system process (GO:0003012)3.56636922
92myoblast fusion (GO:0007520)3.56442402
93regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.55791430
94muscle cell cellular homeostasis (GO:0046716)3.55345009
95regulation of heart contraction (GO:0008016)3.54963721
96muscle structure development (GO:0061061)3.54907907
97regulation of skeletal muscle cell differentiation (GO:2001014)3.54255669
98cardiac ventricle formation (GO:0003211)3.52438669
99detection of calcium ion (GO:0005513)3.51827805
100relaxation of cardiac muscle (GO:0055119)3.51656434
101negative regulation of muscle hypertrophy (GO:0014741)3.50792350
102positive regulation of myoblast differentiation (GO:0045663)3.50097280
103ventricular cardiac muscle cell action potential (GO:0086005)3.49552973
104myotube cell development (GO:0014904)3.47982784
105regulation of membrane repolarization (GO:0060306)3.46143434
106bundle of His cell to Purkinje myocyte communication (GO:0086069)3.46103448
107regulation of striated muscle cell apoptotic process (GO:0010662)3.44644111
108regulation of ATPase activity (GO:0043462)3.41506910
109regulation of ATP catabolic process (GO:1903289)3.41506910
110regulation of cardiac muscle cell differentiation (GO:2000725)3.38011165
111cell communication by electrical coupling (GO:0010644)3.37644994
112skeletal muscle tissue regeneration (GO:0043403)3.37194445
113cardiac chamber formation (GO:0003207)3.36211204
114negative regulation of calcium ion transmembrane transport (GO:1903170)3.35774011
115pyrimidine ribonucleoside catabolic process (GO:0046133)3.34702849
116muscle cell development (GO:0055001)3.28560002
117carnitine shuttle (GO:0006853)3.27644893
118positive regulation of cardiac muscle tissue development (GO:0055025)3.20983576
119regulation of muscle contraction (GO:0006937)3.18714670
120regulation of cardiac muscle cell apoptotic process (GO:0010665)3.17391576
121NADH metabolic process (GO:0006734)3.15560418
122ubiquinone biosynthetic process (GO:0006744)3.10938188
123quinone biosynthetic process (GO:1901663)3.10938188
124negative regulation of skeletal muscle tissue development (GO:0048642)3.09715262
125positive regulation of cardiac muscle tissue growth (GO:0055023)3.09433532
126regulation of sulfur metabolic process (GO:0042762)3.07998058
127cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05177847
128positive regulation of cardiac muscle cell proliferation (GO:0060045)3.04148384
129regulation of muscle system process (GO:0090257)3.01941171
130ubiquinone metabolic process (GO:0006743)2.99132726
131membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98785596
132cardiac muscle cell action potential involved in contraction (GO:0086002)2.98632814
133actin-myosin filament sliding (GO:0033275)10.1632618
134muscle filament sliding (GO:0030049)10.1632618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.23682309
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.21599096
3EP300_21415370_ChIP-Seq_HL-1_Mouse4.02343551
4EZH2_22144423_ChIP-Seq_EOC_Human3.73705517
5GBX2_23144817_ChIP-Seq_PC3_Human3.04396235
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.73637184
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47690285
8MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.44570179
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38281809
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.36943255
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34146045
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31073895
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05923759
14TBX20_22080862_ChIP-Seq_HEART_Mouse2.04232752
15TBX20_22328084_ChIP-Seq_HEART_Mouse2.04232752
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.01643578
17VDR_22108803_ChIP-Seq_LS180_Human2.00791802
18TAF15_26573619_Chip-Seq_HEK293_Human1.96114643
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95039654
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91444999
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88685243
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87293576
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84839190
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84839190
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.84540833
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82687292
27GATA4_21415370_ChIP-Seq_HL-1_Mouse1.69726882
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.67613908
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67205959
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66596741
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63823549
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60442951
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.59893278
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59886736
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58137198
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.56863130
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55633745
38ZNF274_21170338_ChIP-Seq_K562_Hela1.55074774
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54132288
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50985199
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.50204314
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49576223
43FUS_26573619_Chip-Seq_HEK293_Human1.49452686
44* EZH2_27294783_Chip-Seq_ESCs_Mouse1.49095058
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47683424
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46624101
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46253174
48* ISL1_27105846_Chip-Seq_CPCs_Mouse1.45859837
49SMAD4_21799915_ChIP-Seq_A2780_Human1.42259442
50P300_19829295_ChIP-Seq_ESCs_Human1.41719725
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40497593
52CJUN_26792858_Chip-Seq_BT549_Human1.39626058
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.39466701
54NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34925272
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34505252
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.34077320
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33033477
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.31244486
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30952616
60* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30142451
61* SOX9_26525672_Chip-Seq_HEART_Mouse1.30088814
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.28840506
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28627618
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28580996
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28223551
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27533121
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27182244
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25636322
69CLOCK_20551151_ChIP-Seq_293T_Human1.22955253
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21145998
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20551782
72TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20413991
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20205032
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.19516199
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18276881
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15877696
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.15857022
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13587300
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13374176
80SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12856740
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.12727606
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11731705
83ER_23166858_ChIP-Seq_MCF-7_Human1.10908804
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09613321
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.09135038
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06732393
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06596700
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.06240928
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06121244
90PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05947095
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04959927
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04548544
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03920807
94BCAT_22108803_ChIP-Seq_LS180_Human1.03863586
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03826382
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03768858
97REST_21632747_ChIP-Seq_MESCs_Mouse1.02865846
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02376015
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02330029
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02275624
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01749680
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01514372
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01320226
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98231579
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98072852
106NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98072852
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97510875
108DROSHA_22980978_ChIP-Seq_HELA_Human0.97205199
109NFE2_27457419_Chip-Seq_LIVER_Mouse0.96744451
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96645257
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.96562280
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93162062
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.92578900
114* TCF4_23295773_ChIP-Seq_U87_Human0.92405168
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91867878
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91450387
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91157356
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90913676
119PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90371605
120SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89927143
121* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89801835
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89593359
123AR_25329375_ChIP-Seq_VCAP_Human0.89472815
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.89437429
125TP53_16413492_ChIP-PET_HCT116_Human0.89391295
126* MYC_19829295_ChIP-Seq_ESCs_Human0.88453011
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.88303730
128* AR_19668381_ChIP-Seq_PC3_Human0.88269808
129NANOG_19829295_ChIP-Seq_ESCs_Human0.88247301
130SOX2_19829295_ChIP-Seq_ESCs_Human0.88247301
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87574148
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86431611
133IGF1R_20145208_ChIP-Seq_DFB_Human0.86044847
134TP53_23651856_ChIP-Seq_MEFs_Mouse0.85144951
135NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85127947
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84936339
137BRD4_25478319_ChIP-Seq_HGPS_Human0.83028854
138GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82716299
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82482139
140CTCF_27219007_Chip-Seq_Bcells_Human0.82410718
141GF1_26923725_Chip-Seq_HPCs_Mouse0.81838605
142OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81700190
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78996873
144SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78031843
145TBL1_22424771_ChIP-Seq_293T_Human0.77495949

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration6.07056869
2MP0004084_abnormal_cardiac_muscle5.14046476
3MP0004036_abnormal_muscle_relaxation4.64651439
4MP0004145_abnormal_muscle_electrophysio4.59979250
5MP0000751_myopathy4.55309671
6MP0002837_dystrophic_cardiac_calcinosis4.49331713
7MP0003646_muscle_fatigue3.99727744
8MP0004215_abnormal_myocardial_fiber3.41503866
9MP0005330_cardiomyopathy3.36958596
10MP0004087_abnormal_muscle_fiber3.14851143
11MP0002972_abnormal_cardiac_muscle3.12702289
12MP0005620_abnormal_muscle_contractility3.09945018
13MP0002106_abnormal_muscle_physiology2.91533684
14MP0002269_muscular_atrophy2.65130612
15MP0000747_muscle_weakness2.50142750
16MP0008775_abnormal_heart_ventricle2.39766683
17MP0005369_muscle_phenotype2.37808479
18MP0000759_abnormal_skeletal_muscle2.34688838
19MP0003221_abnormal_cardiomyocyte_apopto2.27349914
20MP0004510_myositis2.27276915
21MP0003137_abnormal_impulse_conducting2.21596627
22MP0010630_abnormal_cardiac_muscle2.17100794
23MP0004484_altered_response_of2.16982330
24MP0005385_cardiovascular_system_phenoty2.05829807
25MP0001544_abnormal_cardiovascular_syste2.05829807
26MP0000750_abnormal_muscle_regeneration2.05196410
27MP0006138_congestive_heart_failure2.00628059
28MP0004085_abnormal_heartbeat1.98085439
29MP0004233_abnormal_muscle_weight1.95247689
30MP0006036_abnormal_mitochondrial_physio1.91219442
31MP0002127_abnormal_cardiovascular_syste1.89583292
32MP0004130_abnormal_muscle_cell1.87868096
33MP0003880_abnormal_central_pattern1.83732818
34MP0003828_pulmonary_edema1.74666191
35MP0003122_maternal_imprinting1.71762179
36MP0002332_abnormal_exercise_endurance1.68004483
37MP0003950_abnormal_plasma_membrane1.63860879
38MP0003279_aneurysm1.48910227
39MP0005451_abnormal_body_composition1.41341230
40MP0006035_abnormal_mitochondrial_morpho1.33044244
41MP0004859_abnormal_synaptic_plasticity1.27104451
42MP0003567_abnormal_fetal_cardiomyocyte1.26351603
43MP0005670_abnormal_white_adipose1.23684810
44MP0001968_abnormal_touch/_nociception1.19504213
45MP0003123_paternal_imprinting1.19196572
46MP0002736_abnormal_nociception_after1.16285337
47MP0008438_abnormal_cutaneous_collagen1.11757908
48MP0009780_abnormal_chondrocyte_physiolo1.09327741
49MP0010368_abnormal_lymphatic_system1.04225046
50MP0004270_analgesia1.02969861
51MP0003705_abnormal_hypodermis_morpholog1.02949196
52MP0001661_extended_life_span0.99435890
53MP0009745_abnormal_behavioral_response0.99267077
54MP0003635_abnormal_synaptic_transmissio0.92585310
55MP0001542_abnormal_bone_strength0.92212919
56MP0000266_abnormal_heart_morphology0.91109968
57MP0005503_abnormal_tendon_morphology0.88801763
58MP0009384_cardiac_valve_regurgitation0.83714294
59MP0002108_abnormal_muscle_morphology0.83122410
60MP0003121_genomic_imprinting0.81528292
61MP0004185_abnormal_adipocyte_glucose0.79585157
62MP0005266_abnormal_metabolism0.79551610
63MP0002064_seizures0.79367473
64MP0000767_abnormal_smooth_muscle0.78090647
65MP0000230_abnormal_systemic_arterial0.77524044
66MP0005171_absent_coat_pigmentation0.74888608
67MP0001958_emphysema0.74571474
68MP0001299_abnormal_eye_distance/0.74342534
69MP0002063_abnormal_learning/memory/cond0.74275631
70MP0009046_muscle_twitch0.72380362
71MP0004043_abnormal_pH_regulation0.71506462
72MP0003879_abnormal_hair_cell0.71434077
73MP0002067_abnormal_sensory_capabilities0.70645429
74MP0003045_fibrosis0.70151380
75MP0005275_abnormal_skin_tensile0.69714927
76MP0005666_abnormal_adipose_tissue0.66904060
77MP0002572_abnormal_emotion/affect_behav0.62801478
78MP0000343_altered_response_to0.62696679
79MP0003806_abnormal_nucleotide_metabolis0.62336398
80MP0002734_abnormal_mechanical_nocicepti0.60509917
81MP0002735_abnormal_chemical_nociception0.60342429
82MP0009697_abnormal_copulation0.59856659
83MP0000762_abnormal_tongue_morphology0.59807834
84MP0000733_abnormal_muscle_development0.58609088
85MP0000372_irregular_coat_pigmentation0.57957810
86MP0001440_abnormal_grooming_behavior0.57204285
87MP0001485_abnormal_pinna_reflex0.55127211
88MP0002272_abnormal_nervous_system0.54166192
89MP0004142_abnormal_muscle_tone0.54069257
90MP0004272_abnormal_basement_membrane0.53012022
91MP0002295_abnormal_pulmonary_circulatio0.51279190
92MP0000003_abnormal_adipose_tissue0.51182903
93MP0010030_abnormal_orbit_morphology0.50230217
94MP0005595_abnormal_vascular_smooth0.50201131
95MP0001529_abnormal_vocalization0.49412610
96MP0003566_abnormal_cell_adhesion0.49025594
97MP0005386_behavior/neurological_phenoty0.46081578
98MP0004924_abnormal_behavior0.46081578
99MP0002933_joint_inflammation0.45108359
100MP0003385_abnormal_body_wall0.43417749
101MP0001486_abnormal_startle_reflex0.40219989
102MP0002234_abnormal_pharynx_morphology0.39841392
103MP0002066_abnormal_motor_capabilities/c0.39727413
104MP0005165_increased_susceptibility_to0.39721592
105MP0002128_abnormal_blood_circulation0.39706462
106MP0000013_abnormal_adipose_tissue0.39531770
107MP0005187_abnormal_penis_morphology0.39132766
108MP0003984_embryonic_growth_retardation0.39020664
109MP0002088_abnormal_embryonic_growth/wei0.38195653
110MP0001879_abnormal_lymphatic_vessel0.38007234
111MP0003136_yellow_coat_color0.37355981
112MP0008569_lethality_at_weaning0.36604743
113MP0002896_abnormal_bone_mineralization0.36202484
114MP0005623_abnormal_meninges_morphology0.35857829
115MP0005646_abnormal_pituitary_gland0.34846092
116MP0008877_abnormal_DNA_methylation0.34541740
117MP0002925_abnormal_cardiovascular_devel0.34102517
118MP0005375_adipose_tissue_phenotype0.33436638
119MP0004147_increased_porphyrin_level0.33395998
120MP0002971_abnormal_brown_adipose0.32991659
121MP0005423_abnormal_somatic_nervous0.32083124
122MP0003941_abnormal_skin_development0.31615254
123MP0003948_abnormal_gas_homeostasis0.30969199
124MP0009250_abnormal_appendicular_skeleto0.30680765
125MP0001784_abnormal_fluid_regulation0.28960569
126MP0003091_abnormal_cell_migration0.28838219
127MP0001905_abnormal_dopamine_level0.28684988
128MP0002114_abnormal_axial_skeleton0.28111750
129MP0008004_abnormal_stomach_pH0.25898058
130MP0000249_abnormal_blood_vessel0.24951742
131MP0001614_abnormal_blood_vessel0.23102469
132MP0004134_abnormal_chest_morphology0.21178949
133MP0005023_abnormal_wound_healing0.20955051
134MP0004883_abnormal_blood_vessel0.20231158
135MP0002822_catalepsy0.19783283
136MP0002102_abnormal_ear_morphology0.19252895
137MP0005376_homeostasis/metabolism_phenot0.18411465
138MP0000467_abnormal_esophagus_morphology0.18332796
139MP0002168_other_aberrant_phenotype0.18056223
140MP0002249_abnormal_larynx_morphology0.17571814

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)7.55132953
2Exercise-induced myalgia (HP:0003738)7.38091915
3Calf muscle hypertrophy (HP:0008981)7.15808159
4Muscle hypertrophy of the lower extremities (HP:0008968)7.01692370
5Sudden death (HP:0001699)6.05606393
6Abnormality of the calf musculature (HP:0001430)5.33515022
7Popliteal pterygium (HP:0009756)5.21270665
8Muscle fiber inclusion bodies (HP:0100299)5.21002166
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.11446229
10Abnormality of the left ventricular outflow tract (HP:0011103)4.90135844
11Subaortic stenosis (HP:0001682)4.90135844
12Nemaline bodies (HP:0003798)4.81650196
13Type 1 muscle fiber predominance (HP:0003803)4.66775195
14Type 2 muscle fiber atrophy (HP:0003554)4.66560023
15EMG: myopathic abnormalities (HP:0003458)4.59237390
16Myoglobinuria (HP:0002913)4.58783452
17Ventricular tachycardia (HP:0004756)4.54318146
18Atrial fibrillation (HP:0005110)4.37831059
19Muscle fiber atrophy (HP:0100295)4.22920871
20Muscle fiber splitting (HP:0003555)4.15254894
21Acute necrotizing encephalopathy (HP:0006965)4.09837888
22Lipoatrophy (HP:0100578)4.07622592
23Fatigable weakness (HP:0003473)4.06762232
24Abnormality of the neuromuscular junction (HP:0003398)4.06762232
25Primary atrial arrhythmia (HP:0001692)4.02595369
26Abnormal mitochondria in muscle tissue (HP:0008316)3.93379945
27Supraventricular tachycardia (HP:0004755)3.88561970
28Amniotic constriction ring (HP:0009775)3.86902982
29Abnormality of placental membranes (HP:0011409)3.86902982
30Weak cry (HP:0001612)3.86116109
31Rhabdomyolysis (HP:0003201)3.79200123
32Supraventricular arrhythmia (HP:0005115)3.77953361
33Aplasia of the musculature (HP:0100854)3.65404702
34Abnormality of glycolysis (HP:0004366)3.56348664
35Increased serum pyruvate (HP:0003542)3.56348664
36* Hyporeflexia of lower limbs (HP:0002600)3.48449378
37Asymmetric septal hypertrophy (HP:0001670)3.47296657
38Distal arthrogryposis (HP:0005684)3.39399893
39Centrally nucleated skeletal muscle fibers (HP:0003687)3.36628078
40Progressive macrocephaly (HP:0004481)3.36599386
41Neck muscle weakness (HP:0000467)3.33208505
42Acute encephalopathy (HP:0006846)3.28975092
43Myotonia (HP:0002486)3.28438681
44Round ear (HP:0100830)3.28321302
45Dilated cardiomyopathy (HP:0001644)3.23878436
46Mitochondrial inheritance (HP:0001427)3.16582009
47Muscle stiffness (HP:0003552)3.10185305
48Prolonged QT interval (HP:0001657)3.05965655
49Exercise intolerance (HP:0003546)3.04669922
50Rimmed vacuoles (HP:0003805)3.00158074
51Increased CSF lactate (HP:0002490)2.98879384
52Syncope (HP:0001279)2.98606690
53Difficulty running (HP:0009046)2.93099938
54* Distal lower limb muscle weakness (HP:0009053)2.92442930
55Ventricular arrhythmia (HP:0004308)2.92067946
56Left ventricular hypertrophy (HP:0001712)2.89003723
57Deformed tarsal bones (HP:0008119)2.85802717
58Palpitations (HP:0001962)2.82179396
59Easy fatigability (HP:0003388)2.81553697
60Increased connective tissue (HP:0009025)2.79363658
61Bulbar palsy (HP:0001283)2.79161514
62Pheochromocytoma (HP:0002666)2.76540044
63Myopathic facies (HP:0002058)2.75772762
64Congenital malformation of the right heart (HP:0011723)2.74842456
65Double outlet right ventricle (HP:0001719)2.74842456
66Ragged-red muscle fibers (HP:0003200)2.71143108
67Hepatic necrosis (HP:0002605)2.67453592
68Right ventricular cardiomyopathy (HP:0011663)2.66531707
69Neuroendocrine neoplasm (HP:0100634)2.66493109
70Hepatocellular necrosis (HP:0001404)2.63776999
71Atrioventricular block (HP:0001678)2.56194619
72Generalized muscle weakness (HP:0003324)2.54569892
73* EMG: neuropathic changes (HP:0003445)2.49952799
74Respiratory insufficiency due to muscle weakness (HP:0002747)2.47272068
75Abnormal finger flexion creases (HP:0006143)2.42446852
76Hypoplastic left heart (HP:0004383)2.42409463
77Cerebral edema (HP:0002181)2.40530929
78Hypoplastic heart (HP:0001961)2.37757201
79Thin ribs (HP:0000883)2.37664585
80Bundle branch block (HP:0011710)2.36888030
81Pterygium (HP:0001059)2.34635817
82Abnormality of skeletal muscle fiber size (HP:0012084)2.33589283
83Scapular winging (HP:0003691)2.32373637
84Conjunctival hamartoma (HP:0100780)2.31780409
85Ulnar deviation of the wrist (HP:0003049)2.31583388
86Limb-girdle muscle atrophy (HP:0003797)2.28932483
87Hyperventilation (HP:0002883)2.26034876
88Aortic aneurysm (HP:0004942)2.24780025
89Abnormal EKG (HP:0003115)2.21700996
90Lactic acidosis (HP:0003128)2.21528274
91Increased variability in muscle fiber diameter (HP:0003557)2.18905875
92Respiratory failure (HP:0002878)2.16965216
93Absent phalangeal crease (HP:0006109)2.11569586
94Distal lower limb amyotrophy (HP:0008944)2.10168973
95Focal motor seizures (HP:0011153)2.10017886
96Frequent falls (HP:0002359)2.08633298
97Palmoplantar keratoderma (HP:0000982)2.06720373
98Heart block (HP:0012722)2.06582205
99Nonprogressive disorder (HP:0003680)2.06112085
100Hip contracture (HP:0003273)2.04847222
101Cholecystitis (HP:0001082)2.03472416
102Abnormal gallbladder physiology (HP:0012438)2.03472416
103Neoplasm of the adrenal gland (HP:0100631)2.02216458
104Difficulty climbing stairs (HP:0003551)1.99863556
105Optic disc pallor (HP:0000543)1.94300487
106Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91231157
107Muscular dystrophy (HP:0003560)1.91141364
108Increased intramyocellular lipid droplets (HP:0012240)1.90428019
109Gowers sign (HP:0003391)1.90070325
110Increased hepatocellular lipid droplets (HP:0006565)1.89728414
111Abnormal atrioventricular conduction (HP:0005150)1.89693932
112* Areflexia of lower limbs (HP:0002522)1.88934649
113Akinesia (HP:0002304)1.88422316
114Abnormality of the foot musculature (HP:0001436)1.88116829
115Calcaneovalgus deformity (HP:0001848)1.87151638
116Mildly elevated creatine phosphokinase (HP:0008180)1.86630229
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86490334
118Lipid accumulation in hepatocytes (HP:0006561)1.83182605
119Malignant hyperthermia (HP:0002047)1.82816888
120Increased serum lactate (HP:0002151)1.79112861
121Atonic seizures (HP:0010819)1.77949777
122Foot dorsiflexor weakness (HP:0009027)1.77716374
123Ventricular fibrillation (HP:0001663)1.77149967
124Fetal akinesia sequence (HP:0001989)1.76831928
125Increased muscle lipid content (HP:0009058)1.76506478
126Diaphragmatic weakness (HP:0009113)1.74994776
127Epileptic encephalopathy (HP:0200134)1.74839468
128Leukodystrophy (HP:0002415)1.71187928
129Abnormality of the shoulder girdle musculature (HP:0001435)1.70404449
130Proximal amyotrophy (HP:0007126)1.68068620
131Abnormality of the calcaneus (HP:0008364)1.67829700
132Cystic hygroma (HP:0000476)1.67746547
133Waddling gait (HP:0002515)1.67489079
134Congestive heart failure (HP:0001635)1.61050159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN9.26068622
2MYLK4.02182769
3CASK3.91540791
4TTN3.15911071
5STK242.87288308
6PIK3CA2.62637463
7PHKG12.52553610
8PHKG22.52553610
9CCNB12.43224942
10ZAK2.31646999
11EPHA42.12113999
12DAPK22.01644660
13PDK31.79453936
14PDK41.79453936
15NME11.78729082
16DMPK1.78013461
17PLK21.67336902
18MUSK1.63977102
19MOS1.62191523
20NEK11.60721472
21STK38L1.56379526
22DAPK31.55176026
23PKN21.55143462
24MAPK121.40903511
25MAPKAPK31.38829352
26MAP2K41.34117799
27AKT31.27415732
28CDC42BPA1.23558685
29PIK3CG1.21616346
30MAP3K41.19458792
31PDK21.17359785
32LIMK11.16403960
33TRPM71.11860130
34MARK11.09865241
35PTK2B1.09642822
36ILK1.07948786
37NEK91.04609715
38MAP2K71.00606361
39DAPK10.93549464
40MAP2K30.93389533
41TGFBR20.91521744
42MAP3K70.91089061
43PRPF4B0.81303036
44PRKD30.81097696
45CDK190.80999233
46PINK10.80696376
47CAMK2A0.79562492
48MAPK130.78718276
49CAMK2D0.73497442
50BCKDK0.72608444
51MAPK70.69561580
52MAP2K10.69518427
53ROCK10.69196527
54CAMK10.67753061
55OXSR10.64504675
56STK390.63146301
57PKN10.61965653
58MAPK40.60510562
59MAPKAPK50.59963837
60BLK0.58074397
61NTRK30.56696145
62MAP3K120.55384242
63CAMKK20.54550055
64RIPK10.50375456
65PRKG10.50125472
66PRKACB0.50046481
67MAP2K60.49649253
68ROCK20.48864853
69CAMK2G0.48444630
70TESK10.47495581
71PAK30.46822020
72DDR20.46784875
73PRKAA20.44052260
74SGK10.43956217
75FGFR10.43729057
76PAK20.43705221
77PAK60.43519438
78CAMK2B0.42982297
79MAP3K50.42397456
80PRKACA0.41971504
81SGK20.40512972
82CAMK40.39951640
83WNK40.39635237
84KSR10.39359707
85MAP3K30.37721733
86TRIB30.34135908
87LMTK20.33255421
88ERBB30.32963648
89MELK0.32166398
90LATS20.32143056
91PRKCE0.31841349
92PRKAA10.31443296
93TIE10.31129923
94MARK30.31121857
95PRKACG0.30713035
96BRAF0.30623145
97AKT20.30055606
98INSRR0.29301592
99RPS6KL10.28790948
100RPS6KC10.28790948
101EPHB20.28471381
102BCR0.27828555
103ARAF0.27495810
104MARK20.27193468
105GRK70.26966494
106SGK4940.26879106
107SGK2230.26879106
108SIK30.26694024
109FER0.26563490
110MAP3K60.26558834
111PRKD10.26337994
112GRK50.26180243
113ADRBK10.24483873
114CDK80.24473701
115KSR20.24316287
116MINK10.24005640
117FLT30.23623127
118RPS6KA60.22963766
119CDK30.22873767
120STK160.21058578
121CDK180.20527723
122TAOK20.19867103
123PRKG20.19866641
124PTK20.19050283
125RPS6KA30.18040636
126WNK10.17821724
127PRKCQ0.17465284
128STK40.16846609
129TNIK0.16813233
130MAPK110.15360609
131EPHA30.13016943
132PRKCA0.12217555
133DYRK1B0.12073984
134RPS6KA10.11659878
135SCYL20.11226217
136RAF10.10997367
137PDPK10.10456328
138MAPK100.10241703
139EEF2K0.09765089

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042605.46758191
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.08643404
3Oxidative phosphorylation_Homo sapiens_hsa001904.47810148
4Parkinsons disease_Homo sapiens_hsa050124.23529219
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.75050713
6Dilated cardiomyopathy_Homo sapiens_hsa054143.57936819
7Alzheimers disease_Homo sapiens_hsa050103.26733855
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.89082523
9Huntingtons disease_Homo sapiens_hsa050162.87555870
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.51074257
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.20200190
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16461627
13Carbon metabolism_Homo sapiens_hsa012002.13839469
14Propanoate metabolism_Homo sapiens_hsa006401.91948607
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.91100040
16Pyruvate metabolism_Homo sapiens_hsa006201.72655992
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51458017
18Oxytocin signaling pathway_Homo sapiens_hsa049211.51055815
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35204559
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.33512945
21Biosynthesis of amino acids_Homo sapiens_hsa012301.33309989
22Calcium signaling pathway_Homo sapiens_hsa040201.29968293
23Arginine and proline metabolism_Homo sapiens_hsa003301.26280315
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22768576
25Circadian entrainment_Homo sapiens_hsa047131.18699392
26Glucagon signaling pathway_Homo sapiens_hsa049221.13260733
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09150912
28Fructose and mannose metabolism_Homo sapiens_hsa000511.09129492
29Nicotine addiction_Homo sapiens_hsa050331.07764908
30ECM-receptor interaction_Homo sapiens_hsa045121.06382652
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05071434
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03543721
33Arginine biosynthesis_Homo sapiens_hsa002200.99252232
34Circadian rhythm_Homo sapiens_hsa047100.97761918
35Vascular smooth muscle contraction_Homo sapiens_hsa042700.96847688
36Long-term potentiation_Homo sapiens_hsa047200.91546450
37Tight junction_Homo sapiens_hsa045300.88815212
38Galactose metabolism_Homo sapiens_hsa000520.88606165
39Fatty acid elongation_Homo sapiens_hsa000620.88555698
40HIF-1 signaling pathway_Homo sapiens_hsa040660.86794874
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86316383
42Insulin secretion_Homo sapiens_hsa049110.85997942
43Synaptic vesicle cycle_Homo sapiens_hsa047210.85783797
44Collecting duct acid secretion_Homo sapiens_hsa049660.84608827
45Starch and sucrose metabolism_Homo sapiens_hsa005000.80721144
46Amphetamine addiction_Homo sapiens_hsa050310.80342372
47Renin secretion_Homo sapiens_hsa049240.78017111
48Olfactory transduction_Homo sapiens_hsa047400.77135504
49Fatty acid degradation_Homo sapiens_hsa000710.77110304
50Proteasome_Homo sapiens_hsa030500.76708740
51Morphine addiction_Homo sapiens_hsa050320.75186683
52Fatty acid metabolism_Homo sapiens_hsa012120.72527581
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69347907
54Phenylalanine metabolism_Homo sapiens_hsa003600.65171635
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.64871030
56GABAergic synapse_Homo sapiens_hsa047270.64518759
57Insulin signaling pathway_Homo sapiens_hsa049100.64130270
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63868628
59Gastric acid secretion_Homo sapiens_hsa049710.58767129
60Ovarian steroidogenesis_Homo sapiens_hsa049130.58596886
61Glutamatergic synapse_Homo sapiens_hsa047240.57667336
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56716698
63Proteoglycans in cancer_Homo sapiens_hsa052050.55788637
64Sulfur metabolism_Homo sapiens_hsa009200.55750121
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55179058
66Amoebiasis_Homo sapiens_hsa051460.54361071
67Dopaminergic synapse_Homo sapiens_hsa047280.54160836
68Long-term depression_Homo sapiens_hsa047300.53724900
69Viral myocarditis_Homo sapiens_hsa054160.52526118
70Salivary secretion_Homo sapiens_hsa049700.51463316
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.50679102
72Taste transduction_Homo sapiens_hsa047420.49601389
73Platelet activation_Homo sapiens_hsa046110.49217680
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48605712
75Focal adhesion_Homo sapiens_hsa045100.47162439
76Serotonergic synapse_Homo sapiens_hsa047260.44918225
77Insulin resistance_Homo sapiens_hsa049310.44428352
78cAMP signaling pathway_Homo sapiens_hsa040240.43680908
79Cholinergic synapse_Homo sapiens_hsa047250.40754517
80GnRH signaling pathway_Homo sapiens_hsa049120.40325308
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39497232
82Type II diabetes mellitus_Homo sapiens_hsa049300.38359988
83Tryptophan metabolism_Homo sapiens_hsa003800.37848998
84Melanogenesis_Homo sapiens_hsa049160.37469170
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.36920981
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36623782
87Metabolic pathways_Homo sapiens_hsa011000.36525075
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.34566192
89Vibrio cholerae infection_Homo sapiens_hsa051100.30341175
90Tyrosine metabolism_Homo sapiens_hsa003500.30075936
91beta-Alanine metabolism_Homo sapiens_hsa004100.29992707
92Regulation of autophagy_Homo sapiens_hsa041400.26756773
93Axon guidance_Homo sapiens_hsa043600.25242278
94Lysine degradation_Homo sapiens_hsa003100.24819306
95AMPK signaling pathway_Homo sapiens_hsa041520.24584330
96MAPK signaling pathway_Homo sapiens_hsa040100.22653073
97Adherens junction_Homo sapiens_hsa045200.21261707
98Gap junction_Homo sapiens_hsa045400.20865594
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20519223
100Protein digestion and absorption_Homo sapiens_hsa049740.20292410
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.20216542
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19859454
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19724769
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19292218
105Bile secretion_Homo sapiens_hsa049760.19261105
106Oocyte meiosis_Homo sapiens_hsa041140.18833148
107Purine metabolism_Homo sapiens_hsa002300.16841965
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.16768820
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.16322564
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14609172
111Thyroid hormone synthesis_Homo sapiens_hsa049180.14427359
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12749026
113Prion diseases_Homo sapiens_hsa050200.12624120
114FoxO signaling pathway_Homo sapiens_hsa040680.12478971
115Pentose phosphate pathway_Homo sapiens_hsa000300.11790371
116Pancreatic secretion_Homo sapiens_hsa049720.11615144
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.11234064
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11206810
119Peroxisome_Homo sapiens_hsa041460.11012515
120Hippo signaling pathway_Homo sapiens_hsa043900.08054513
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07693364
122Butanoate metabolism_Homo sapiens_hsa006500.07375657
123Wnt signaling pathway_Homo sapiens_hsa043100.07216221
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.06120467
125PPAR signaling pathway_Homo sapiens_hsa033200.06067983

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