HSPB9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.96708436
2plasma membrane fusion (GO:0045026)9.48438508
3axonemal dynein complex assembly (GO:0070286)9.39448743
4epithelial cilium movement (GO:0003351)9.28109020
5motile cilium assembly (GO:0044458)9.24290392
6reproduction (GO:0000003)8.87233977
7cilium or flagellum-dependent cell motility (GO:0001539)8.35582696
8regulation of cilium movement (GO:0003352)8.10065856
9negative regulation of inclusion body assembly (GO:0090084)7.95351633
10synaptonemal complex organization (GO:0070193)7.76743452
11synaptonemal complex assembly (GO:0007130)7.68911714
12piRNA metabolic process (GO:0034587)7.59295611
13male meiosis (GO:0007140)7.53916499
14cilium movement (GO:0003341)7.53671422
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.18976672
16spermatogenesis (GO:0007283)7.02804647
17male gamete generation (GO:0048232)7.00269422
18single fertilization (GO:0007338)6.96150549
19sperm capacitation (GO:0048240)6.93177062
20organic cation transport (GO:0015695)6.75095046
21regulation of inclusion body assembly (GO:0090083)6.46124091
22gamete generation (GO:0007276)6.42944701
23microtubule depolymerization (GO:0007019)6.39840793
24chromosome condensation (GO:0030261)6.14236850
25fertilization (GO:0009566)6.10750568
26DNA packaging (GO:0006323)5.80072278
27calcium ion-dependent exocytosis (GO:0017156)5.62010625
28germ cell development (GO:0007281)5.54924008
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.43357812
30spermatid nucleus differentiation (GO:0007289)5.32852848
31cornea development in camera-type eye (GO:0061303)5.28209837
32chromosome organization involved in meiosis (GO:0070192)5.20069550
33glycerol ether metabolic process (GO:0006662)5.13901065
34cell recognition (GO:0008037)5.03978187
35multicellular organismal reproductive process (GO:0048609)5.03467459
36seminiferous tubule development (GO:0072520)5.03441973
37preassembly of GPI anchor in ER membrane (GO:0016254)5.00907707
38male meiosis I (GO:0007141)4.99031151
39behavioral response to nicotine (GO:0035095)4.98721594
40DNA methylation involved in gamete generation (GO:0043046)4.96313569
41microtubule severing (GO:0051013)4.89575169
42ventricular system development (GO:0021591)4.81331577
43regulation of microtubule-based movement (GO:0060632)4.79520507
44ether metabolic process (GO:0018904)4.74624976
45sexual reproduction (GO:0019953)4.58768311
46DNA deamination (GO:0045006)4.51812682
47chaperone-mediated protein complex assembly (GO:0051131)4.50594034
48meiotic nuclear division (GO:0007126)4.44316462
49single strand break repair (GO:0000012)4.29798790
50multicellular organismal development (GO:0007275)4.09685741
51sequestering of actin monomers (GO:0042989)4.09309315
52left/right pattern formation (GO:0060972)4.08291882
53base-excision repair, AP site formation (GO:0006285)4.03397920
54meiosis I (GO:0007127)4.00214910
55platelet dense granule organization (GO:0060155)3.91170963
56water-soluble vitamin biosynthetic process (GO:0042364)3.83942863
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.74704592
58establishment of protein localization to mitochondrial membrane (GO:0090151)3.73973709
59cellular response to ATP (GO:0071318)3.65519473
60peptidyl-histidine modification (GO:0018202)3.60632543
61neuronal action potential (GO:0019228)3.59892264
62fucose catabolic process (GO:0019317)3.59797297
63L-fucose metabolic process (GO:0042354)3.59797297
64L-fucose catabolic process (GO:0042355)3.59797297
65genitalia morphogenesis (GO:0035112)3.59132509
66meiotic cell cycle (GO:0051321)3.56915088
67protein polyglutamylation (GO:0018095)3.50693441
68regulation of spindle checkpoint (GO:0090231)3.49851493
69protein K11-linked deubiquitination (GO:0035871)3.49647162
70protein complex biogenesis (GO:0070271)3.45952519
71mitochondrial respiratory chain complex I assembly (GO:0032981)3.37252523
72NADH dehydrogenase complex assembly (GO:0010257)3.37252523
73mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37252523
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.37096304
75indolalkylamine metabolic process (GO:0006586)3.34716536
76tryptophan catabolic process (GO:0006569)3.34713712
77indole-containing compound catabolic process (GO:0042436)3.34713712
78indolalkylamine catabolic process (GO:0046218)3.34713712
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34692296
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34692296
81protein refolding (GO:0042026)3.31851990
82chaperone-mediated protein transport (GO:0072321)3.27989163
83regulation of hexokinase activity (GO:1903299)3.26684068
84regulation of glucokinase activity (GO:0033131)3.26684068
85GPI anchor metabolic process (GO:0006505)3.26174504
86protein localization to cilium (GO:0061512)3.25819278
87mitotic sister chromatid cohesion (GO:0007064)3.25079783
88microtubule polymerization or depolymerization (GO:0031109)3.23663575
89detection of light stimulus involved in visual perception (GO:0050908)3.22190650
90detection of light stimulus involved in sensory perception (GO:0050962)3.22190650
91mitochondrial respiratory chain complex assembly (GO:0033108)3.19283579
92carnitine transport (GO:0015879)3.17855351
93amino-acid betaine transport (GO:0015838)3.17855351
94glycolytic process (GO:0006096)3.17671384
95GPI anchor biosynthetic process (GO:0006506)3.17480013
96positive regulation of prostaglandin secretion (GO:0032308)3.16970654
97interferon-gamma secretion (GO:0072643)3.16429659
98positive regulation of macrophage activation (GO:0043032)3.14267415
99C-terminal protein lipidation (GO:0006501)3.12107090
100nucleus organization (GO:0006997)3.11478178
101positive regulation of cell fate commitment (GO:0010455)3.07991628
102tryptophan metabolic process (GO:0006568)3.06995993
103nucleoside diphosphate phosphorylation (GO:0006165)3.03662849
104carnitine transmembrane transport (GO:1902603)3.02926883
105C-terminal protein amino acid modification (GO:0018410)3.00312258
106pyrimidine nucleotide catabolic process (GO:0006244)2.99875567
107monoubiquitinated protein deubiquitination (GO:0035520)2.99303811
108synapsis (GO:0007129)2.98006510
109meiotic cell cycle process (GO:1903046)2.97176567
110receptor guanylyl cyclase signaling pathway (GO:0007168)2.95531531
111regulation of memory T cell differentiation (GO:0043380)2.94637977
112kynurenine metabolic process (GO:0070189)2.94027087
113polyol catabolic process (GO:0046174)2.92797495
114alditol metabolic process (GO:0019400)2.92759871
115chromatin silencing (GO:0006342)2.91824560
116somite rostral/caudal axis specification (GO:0032525)2.89240074
117response to pheromone (GO:0019236)2.88188607
118GTP biosynthetic process (GO:0006183)2.87871924
119mannosylation (GO:0097502)2.86416414
120sphingomyelin metabolic process (GO:0006684)2.86319234
121polyamine biosynthetic process (GO:0006596)2.83921089
122rRNA methylation (GO:0031167)2.83081494
1233-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.82302196
124purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.82302196
125nucleotide transmembrane transport (GO:1901679)2.81299878
126respiratory chain complex IV assembly (GO:0008535)2.78280003
127purinergic nucleotide receptor signaling pathway (GO:0035590)2.77659720
128pseudouridine synthesis (GO:0001522)2.76171607
129cysteine metabolic process (GO:0006534)2.75028170
130synaptic transmission, cholinergic (GO:0007271)2.74079472
131cellular ketone body metabolic process (GO:0046950)2.73233985
132regulation of cilium assembly (GO:1902017)2.72727534
133deoxyribonucleotide catabolic process (GO:0009264)2.69251340
134RNA localization (GO:0006403)2.67500927
135reciprocal meiotic recombination (GO:0007131)2.67458993
136reciprocal DNA recombination (GO:0035825)2.67458993
137termination of RNA polymerase III transcription (GO:0006386)2.66324550
138transcription elongation from RNA polymerase III promoter (GO:0006385)2.66324550
139negative regulation of telomere maintenance (GO:0032205)2.63163437
140estrogen biosynthetic process (GO:0006703)2.62929398
141intraciliary transport (GO:0042073)2.62288179
142microtubule-based movement (GO:0007018)2.62265455
143meiotic chromosome segregation (GO:0045132)2.62202255
144regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.61862518
145regulation of timing of cell differentiation (GO:0048505)2.61594827
146mitochondrion degradation (GO:0000422)2.60256683
147cilium organization (GO:0044782)2.60124529
148rRNA modification (GO:0000154)2.59831881
149RNA destabilization (GO:0050779)2.59596748
150UTP biosynthetic process (GO:0006228)2.58701037
151positive regulation of defense response to virus by host (GO:0002230)2.58599976
152axoneme assembly (GO:0035082)2.58536941
153negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.58147492
154cellular component assembly involved in morphogenesis (GO:0010927)2.57438115
155gene silencing by RNA (GO:0031047)2.56895509
156detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56235164
157cilium morphogenesis (GO:0060271)2.55621705
158regulation of prostaglandin secretion (GO:0032306)2.55608549
159negative regulation of execution phase of apoptosis (GO:1900118)2.55074723
160negative regulation of organelle assembly (GO:1902116)2.54812745
161photoreceptor cell development (GO:0042461)2.53767655
162cytochrome complex assembly (GO:0017004)2.53240015
163membrane protein intracellular domain proteolysis (GO:0031293)2.53016692
164protein prenylation (GO:0018342)2.51389476
165prenylation (GO:0097354)2.51389476
166lactate metabolic process (GO:0006089)2.50991722
167inositol phosphate catabolic process (GO:0071545)2.50117433
168gene silencing (GO:0016458)2.49218779
169amine catabolic process (GO:0009310)2.48357452
170cellular biogenic amine catabolic process (GO:0042402)2.48357452
171regulation of action potential (GO:0098900)2.48214697
172heme transport (GO:0015886)2.47873693
173intracellular protein transmembrane import (GO:0044743)2.47790416
174mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.45366221
175alanine transport (GO:0032328)2.44619232
176ketone body metabolic process (GO:1902224)2.44494994
177ubiquinone biosynthetic process (GO:0006744)2.42680617
178glycerophospholipid catabolic process (GO:0046475)2.41150041
179deoxyribose phosphate catabolic process (GO:0046386)2.41061399
180negative regulation of mast cell activation (GO:0033004)2.37910483
181DNA strand renaturation (GO:0000733)2.37299416
182astrocyte differentiation (GO:0048708)2.37217855
183phosphorylated carbohydrate dephosphorylation (GO:0046838)2.37077825
184sperm motility (GO:0030317)14.0835952
185cell wall macromolecule catabolic process (GO:0016998)12.8070174
186cell wall macromolecule metabolic process (GO:0044036)12.8070174
187fusion of sperm to egg plasma membrane (GO:0007342)12.4602675
188acrosome reaction (GO:0007340)12.4371151
189acrosome assembly (GO:0001675)12.3433770
190sperm-egg recognition (GO:0035036)11.6320260
191binding of sperm to zona pellucida (GO:0007339)10.8337929
192cell-cell recognition (GO:0009988)10.4182602
193multicellular organism reproduction (GO:0032504)10.0965273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.66694342
2EZH2_22144423_ChIP-Seq_EOC_Human4.70853156
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.04541570
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.92512743
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.64970199
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.87182414
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80849760
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.71963079
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60468279
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48952336
11VDR_22108803_ChIP-Seq_LS180_Human2.41955643
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.41846005
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.31376245
14ZNF274_21170338_ChIP-Seq_K562_Hela2.29830766
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.28720410
16IRF1_19129219_ChIP-ChIP_H3396_Human2.26228583
17TP53_22573176_ChIP-Seq_HFKS_Human2.23859702
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.12763645
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10920858
20GBX2_23144817_ChIP-Seq_PC3_Human2.04868450
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92764269
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.90196067
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88893794
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88365373
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85927797
26FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83944820
27MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.83885264
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.83254564
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.82428118
30KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.79709048
31GATA3_21878914_ChIP-Seq_MCF-7_Human1.79519375
32VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.79496214
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.74894429
34FUS_26573619_Chip-Seq_HEK293_Human1.73539713
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71922223
36* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.66966176
37ER_23166858_ChIP-Seq_MCF-7_Human1.66866082
38GATA3_21867929_ChIP-Seq_CD8_Mouse1.66341532
39STAT1_17558387_ChIP-Seq_HELA_Human1.66071570
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65829269
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.65177996
42IGF1R_20145208_ChIP-Seq_DFB_Human1.64841343
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64463465
44VDR_23849224_ChIP-Seq_CD4+_Human1.63984709
45TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62803997
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62066767
47MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59681211
48EWS_26573619_Chip-Seq_HEK293_Human1.55702563
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53263594
50MYC_18940864_ChIP-ChIP_HL60_Human1.52005780
51FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51849203
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.51799423
53GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50948280
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50432715
55* NANOG_20526341_ChIP-Seq_ESCs_Human1.46875062
56FOXP3_21729870_ChIP-Seq_TREG_Human1.45995058
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42976565
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42283634
59P300_19829295_ChIP-Seq_ESCs_Human1.42154544
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.41162537
61P53_21459846_ChIP-Seq_SAOS-2_Human1.39542414
62WDR5_24793694_ChIP-Seq_LNCAP_Human1.39102512
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39067404
64ERA_21632823_ChIP-Seq_H3396_Human1.37442213
65SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36009398
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.35928756
67KDM2B_26808549_Chip-Seq_REH_Human1.35561897
68LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.35405846
69BCAT_22108803_ChIP-Seq_LS180_Human1.35131404
70MYC_19829295_ChIP-Seq_ESCs_Human1.34918812
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32424028
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31911522
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.31544768
74REST_21632747_ChIP-Seq_MESCs_Mouse1.31499725
75HTT_18923047_ChIP-ChIP_STHdh_Human1.30328607
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29101159
77TAF2_19829295_ChIP-Seq_ESCs_Human1.28943565
78CBP_20019798_ChIP-Seq_JUKART_Human1.28498218
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28498218
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28047825
81SOX2_19829295_ChIP-Seq_ESCs_Human1.27735346
82NANOG_19829295_ChIP-Seq_ESCs_Human1.27735346
83AR_20517297_ChIP-Seq_VCAP_Human1.26205357
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26203142
85OCT4_20526341_ChIP-Seq_ESCs_Human1.25182510
86GATA3_21867929_ChIP-Seq_TH1_Mouse1.24511973
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.23292536
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23292536
89GF1_26923725_Chip-Seq_HPCs_Mouse1.22884806
90KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22605239
91CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22538083
92CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22469251
93NCOR_22424771_ChIP-Seq_293T_Human1.20814585
94* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20532768
95* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19143363
96ELK1_19687146_ChIP-ChIP_HELA_Human1.19134785
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19121945
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.18539144
99SPI1_26923725_Chip-Seq_HPCs_Mouse1.18260813
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.17165628
101CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15515455
102PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.14773905
103MYC_27129775_Chip-Seq_CORNEA_Mouse1.13977092
104TAF15_26573619_Chip-Seq_HEK293_Human1.13158625
105* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12881353
106* TET1_21451524_ChIP-Seq_MESCs_Mouse1.12766724
107YY1_22570637_ChIP-Seq_MALME-3M_Human1.12687005
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12617548
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12503095
110* RAC3_21632823_ChIP-Seq_H3396_Human1.12401204
111SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12325437
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12065860
113GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11204512
114CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11111561
115HOXB7_26014856_ChIP-Seq_BT474_Human1.11044371
116CBX2_27304074_Chip-Seq_ESCs_Mouse1.10779722
117ERG_20517297_ChIP-Seq_VCAP_Human1.10754187
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.09425575
119ESET_19884257_ChIP-Seq_ESCs_Mouse1.08789500
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08440790
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08217107
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07356073
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06895091
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06895091
125AR_21572438_ChIP-Seq_LNCaP_Human1.06771210
126CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06537931
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.06438417
128RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04902884
129PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04413645
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03971753
131IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02876275
132E2F1_20622854_ChIP-Seq_HELA_Human1.02594802
133* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01864863
134P300_27268052_Chip-Seq_Bcells_Human1.01695238
135* RARA_24833708_ChIP-Seq_LIVER_Mouse1.01215829
136LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01124741
137NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01066587
138BCOR_27268052_Chip-Seq_Bcells_Human1.00519454
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00399910
140GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00108185
141FOXH1_21741376_ChIP-Seq_EPCs_Human0.99987983
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99923575
143STAT3_23295773_ChIP-Seq_U87_Human0.99093005
144* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98709481
145ELF1_20517297_ChIP-Seq_JURKAT_Human0.98565813
146CTCF_20526341_ChIP-Seq_ESCs_Human0.98372061
147SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97171221
148BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96905648
149IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96036751
150TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96022326
151EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95953198
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95559134
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95479917
154KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95070375
155CRX_20693478_ChIP-Seq_RETINA_Mouse0.94462508
156CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94398579
157GATA3_26560356_Chip-Seq_TH2_Human0.93930641
158PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93294585
159AR_25329375_ChIP-Seq_VCAP_Human0.93189542
160CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92615743
161CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92122135
162EZH2_27294783_Chip-Seq_NPCs_Mouse0.91635995
163FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91420268
164NANOG_18555785_Chip-Seq_ESCs_Mouse0.91405991
165PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90778879
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90591146
167MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89913928
168PHF8_20622854_ChIP-Seq_HELA_Human0.89490148
169BCL6_27268052_Chip-Seq_Bcells_Human0.88809569
170* FLI1_21867929_ChIP-Seq_CD8_Mouse0.88395676
171PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87364299
172* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.87282514
173OCT4_18555785_Chip-Seq_ESCs_Mouse0.86733179
174SOX2_21211035_ChIP-Seq_LN229_Human0.85595481
175NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84305317
176* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83687423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.05751151
2MP0001929_abnormal_gametogenesis5.64782813
3MP0001986_abnormal_taste_sensitivity4.55258368
4MP0008877_abnormal_DNA_methylation4.25010206
5MP0002638_abnormal_pupillary_reflex3.69544872
6MP0006292_abnormal_olfactory_placode3.58301185
7MP0002210_abnormal_sex_determination3.42575943
8MP0002161_abnormal_fertility/fecundity3.29695392
9MP0003195_calcinosis2.93690841
10MP0001145_abnormal_male_reproductive2.90780062
11MP0005670_abnormal_white_adipose2.85659611
12MP0005174_abnormal_tail_pigmentation2.79236644
13MP0000653_abnormal_sex_gland2.49833067
14MP0005083_abnormal_biliary_tract2.47081004
15MP0005084_abnormal_gallbladder_morpholo2.28503967
16MP0008872_abnormal_physiological_respon2.07987528
17MP0003136_yellow_coat_color2.07062110
18MP0008789_abnormal_olfactory_epithelium2.00544257
19MP0005410_abnormal_fertilization16.6414204
20MP0002837_dystrophic_cardiac_calcinosis1.99981182
21MP0005085_abnormal_gallbladder_physiolo1.96399772
22MP0002653_abnormal_ependyma_morphology1.90112388
23MP0000015_abnormal_ear_pigmentation1.87726567
24MP0005171_absent_coat_pigmentation1.83458380
25MP0006072_abnormal_retinal_apoptosis1.81154468
26MP0002163_abnormal_gland_morphology1.77739030
27MP0003252_abnormal_bile_duct1.77148895
28MP0005257_abnormal_intraocular_pressure1.76303942
29MP0001919_abnormal_reproductive_system1.75871863
30MP0002938_white_spotting1.68335743
31MP0002876_abnormal_thyroid_physiology1.60658893
32MP0002160_abnormal_reproductive_system1.52673736
33MP0002102_abnormal_ear_morphology1.51721275
34MP0005379_endocrine/exocrine_gland_phen1.48878857
35MP0003646_muscle_fatigue1.46398443
36MP0005394_taste/olfaction_phenotype1.44976895
37MP0005499_abnormal_olfactory_system1.44976895
38MP0004233_abnormal_muscle_weight1.42150082
39MP0002138_abnormal_hepatobiliary_system1.34311591
40MP0003283_abnormal_digestive_organ1.34128765
41MP0005423_abnormal_somatic_nervous1.30129906
42MP0005645_abnormal_hypothalamus_physiol1.24589652
43MP0001944_abnormal_pancreas_morphology1.21163030
44MP0010386_abnormal_urinary_bladder1.19532002
45MP0001486_abnormal_startle_reflex1.18776290
46MP0005623_abnormal_meninges_morphology1.18120328
47MP0000631_abnormal_neuroendocrine_gland1.17373098
48MP0003806_abnormal_nucleotide_metabolis1.16440637
49MP0002234_abnormal_pharynx_morphology1.16301489
50MP0002095_abnormal_skin_pigmentation1.15799191
51MP0008961_abnormal_basal_metabolism1.15291041
52MP0005646_abnormal_pituitary_gland1.13152008
53MP0002693_abnormal_pancreas_physiology1.12291131
54MP0009745_abnormal_behavioral_response1.11534825
55MP0005332_abnormal_amino_acid1.10870995
56MP0000613_abnormal_salivary_gland1.10693181
57MP0009764_decreased_sensitivity_to1.08728727
58MP0001984_abnormal_olfaction1.07799030
59MP0010329_abnormal_lipoprotein_level1.04845062
60MP0003137_abnormal_impulse_conducting1.04147076
61MP0005671_abnormal_response_to1.03433335
62MP0005220_abnormal_exocrine_pancreas1.01504394
63MP0001765_abnormal_ion_homeostasis1.01129500
64MP0000538_abnormal_urinary_bladder0.98569460
65MP0002735_abnormal_chemical_nociception0.97261750
66MP0000427_abnormal_hair_cycle0.95453797
67MP0002282_abnormal_trachea_morphology0.93194413
68MP0008058_abnormal_DNA_repair0.92141446
69MP0001756_abnormal_urination0.91778482
70MP0001502_abnormal_circadian_rhythm0.90746473
71MP0004147_increased_porphyrin_level0.90641787
72MP0005167_abnormal_blood-brain_barrier0.88355088
73MP0005360_urolithiasis0.87167838
74MP0002272_abnormal_nervous_system0.86360801
75MP0004885_abnormal_endolymph0.84508670
76MP0001501_abnormal_sleep_pattern0.84068940
77MP0003011_delayed_dark_adaptation0.83875036
78MP0005647_abnormal_sex_gland0.83627780
79MP0001905_abnormal_dopamine_level0.82655748
80MP0002064_seizures0.75329890
81MP0001970_abnormal_pain_threshold0.75236743
82MP0001485_abnormal_pinna_reflex0.74645914
83MP0005389_reproductive_system_phenotype0.72962556
84MP0002277_abnormal_respiratory_mucosa0.72706545
85MP0000372_irregular_coat_pigmentation0.70497982
86MP0003119_abnormal_digestive_system0.70065224
87MP0009046_muscle_twitch0.68675015
88MP0003329_amyloid_beta_deposits0.67182669
89MP0002078_abnormal_glucose_homeostasis0.65556145
90MP0006276_abnormal_autonomic_nervous0.64999669
91MP0002254_reproductive_system_inflammat0.64792229
92MP0000013_abnormal_adipose_tissue0.61380985
93MP0003953_abnormal_hormone_level0.60688531
94MP0003115_abnormal_respiratory_system0.60391927
95MP0008995_early_reproductive_senescence0.59827904
96MP0005636_abnormal_mineral_homeostasis0.58348214
97MP0008057_abnormal_DNA_replication0.58174446
98MP0001545_abnormal_hematopoietic_system0.56587232
99MP0005397_hematopoietic_system_phenotyp0.56587232
100MP0004036_abnormal_muscle_relaxation0.56497457
101MP0005666_abnormal_adipose_tissue0.55163709
102MP0010094_abnormal_chromosome_stability0.54660661
103MP0002736_abnormal_nociception_after0.53106716
104MP0006036_abnormal_mitochondrial_physio0.49053334
105MP0009278_abnormal_bone_marrow0.48578430
106MP0002269_muscular_atrophy0.47776811
107MP0000569_abnormal_digit_pigmentation0.47712249
108MP0000358_abnormal_cell_content/0.45835150
109MP0001764_abnormal_homeostasis0.45333705
110MP0003699_abnormal_female_reproductive0.44016882
111MP0001324_abnormal_eye_pigmentation0.43129450
112MP0003878_abnormal_ear_physiology0.40790789
113MP0005377_hearing/vestibular/ear_phenot0.40790789
114MP0001293_anophthalmia0.38822333
115MP0000604_amyloidosis0.37777953
116MP0000534_abnormal_ureter_morphology0.37359077
117MP0001730_embryonic_growth_arrest0.37163759
118MP0004133_heterotaxia0.35603178
119MP0005253_abnormal_eye_physiology0.35227867
120MP0002928_abnormal_bile_duct0.34504217
121MP0003111_abnormal_nucleus_morphology0.33845189
122MP0002139_abnormal_hepatobiliary_system0.33211717
123MP0008007_abnormal_cellular_replicative0.33098666
124MP0009115_abnormal_fat_cell0.30726193
125MP0003786_premature_aging0.29979002
126MP0004811_abnormal_neuron_physiology0.29559590
127MP0005551_abnormal_eye_electrophysiolog0.29141397
128MP0004808_abnormal_hematopoietic_stem0.27896965
129MP0003950_abnormal_plasma_membrane0.27498242
130MP0003633_abnormal_nervous_system0.27495032
131MP0005391_vision/eye_phenotype0.27218963
132MP0001968_abnormal_touch/_nociception0.26479228
133MP0010307_abnormal_tumor_latency0.25578070
134MP0002169_no_abnormal_phenotype0.25258973
135MP0002873_normal_phenotype0.25056234
136MP0003942_abnormal_urinary_system0.23883030
137MP0001119_abnormal_female_reproductive0.23760837
138MP0004019_abnormal_vitamin_homeostasis0.23745941
139MP0003861_abnormal_nervous_system0.23014682
140MP0003631_nervous_system_phenotype0.22863190
141MP0002971_abnormal_brown_adipose0.21692162
142MP0001849_ear_inflammation0.21290876
143MP0002152_abnormal_brain_morphology0.20615698
144MP0003948_abnormal_gas_homeostasis0.20139521
145MP0006035_abnormal_mitochondrial_morpho0.19009049
146MP0003879_abnormal_hair_cell0.18769428
147MP0001727_abnormal_embryo_implantation0.17397564
148MP0000313_abnormal_cell_death0.17100457
149MP0000462_abnormal_digestive_system0.16176114
150MP0008875_abnormal_xenobiotic_pharmacok0.16005050
151MP0004145_abnormal_muscle_electrophysio0.15880136
152MP0000001_mammalian_phenotype0.15268033
153MP0005375_adipose_tissue_phenotype0.15146970
154MP0004043_abnormal_pH_regulation0.15141266
155MP0002092_abnormal_eye_morphology0.14846557
156MP0000751_myopathy0.14287965
157MP0004084_abnormal_cardiac_muscle0.14279947
158MP0005365_abnormal_bile_salt0.14173252
159MP0002295_abnormal_pulmonary_circulatio0.13975516
160MP0002084_abnormal_developmental_patter0.13483551
161MP0003787_abnormal_imprinting0.13390860
162MP0005319_abnormal_enzyme/_coenzyme0.13257565
163MP0002909_abnormal_adrenal_gland0.13125972
164MP0004134_abnormal_chest_morphology0.12810751
165MP0002229_neurodegeneration0.12785567
166MP0003183_abnormal_peptide_metabolism0.11833569
167MP0001672_abnormal_embryogenesis/_devel0.11612226
168MP0005380_embryogenesis_phenotype0.11612226
169MP0001348_abnormal_lacrimal_gland0.11522154

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.56381351
2Abnormal respiratory epithelium morphology (HP:0012253)9.16736310
3Abnormal respiratory motile cilium morphology (HP:0005938)9.16736310
4Chronic bronchitis (HP:0004469)7.72630096
5Rhinitis (HP:0012384)7.64445487
6Abnormal ciliary motility (HP:0012262)7.42658579
7Infertility (HP:0000789)7.17662090
8Nasal polyposis (HP:0100582)6.57316133
9Abnormality of the nasal mucosa (HP:0000433)5.42111030
10Lipid accumulation in hepatocytes (HP:0006561)4.92927906
11Congenital stationary night blindness (HP:0007642)4.74825096
12Bronchitis (HP:0012387)4.57875439
13Male infertility (HP:0003251)4.52358287
14Bronchiectasis (HP:0002110)4.43215163
15Aplasia/Hypoplasia of the fovea (HP:0008060)4.30193940
16Hypoplasia of the fovea (HP:0007750)4.30193940
17Nephronophthisis (HP:0000090)4.02204417
18Attenuation of retinal blood vessels (HP:0007843)3.73202000
19Methylmalonic aciduria (HP:0012120)3.64826857
20Increased hepatocellular lipid droplets (HP:0006565)3.54737254
21Abnormal spermatogenesis (HP:0008669)3.52219627
22Abnormality of the fovea (HP:0000493)3.45408676
23Pendular nystagmus (HP:0012043)3.37968312
24Recurrent otitis media (HP:0000403)3.27977309
25Methylmalonic acidemia (HP:0002912)3.25015282
26Recurrent sinusitis (HP:0011108)3.24464625
27Renal Fanconi syndrome (HP:0001994)3.06157557
28Abnormality of the renal medulla (HP:0100957)2.98858979
29Increased muscle lipid content (HP:0009058)2.91657025
30Pancreatic cysts (HP:0001737)2.84895094
31Abnormal rod and cone electroretinograms (HP:0008323)2.72191887
32Aplasia/Hypoplasia of the macula (HP:0008059)2.70566755
33Mitochondrial inheritance (HP:0001427)2.68607383
34True hermaphroditism (HP:0010459)2.65216361
35Hepatocellular necrosis (HP:0001404)2.63272245
36Type II lissencephaly (HP:0007260)2.58995259
37Tubulointerstitial nephritis (HP:0001970)2.58204628
38Glycosuria (HP:0003076)2.56687902
39Abnormality of urine glucose concentration (HP:0011016)2.56687902
40Tubular atrophy (HP:0000092)2.55477382
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54345815
42Molar tooth sign on MRI (HP:0002419)2.54219491
43Abnormality of midbrain morphology (HP:0002418)2.54219491
44Aplasia/Hypoplasia affecting the retina (HP:0008061)2.51700918
45Exertional dyspnea (HP:0002875)2.48954941
46Recurrent bronchitis (HP:0002837)2.48039001
47Hypoalbuminemia (HP:0003073)2.46128306
48Abnormal albumin level (HP:0012116)2.46128306
49Increased CSF lactate (HP:0002490)2.44279790
50Gonadotropin excess (HP:0000837)2.43350882
51Impulsivity (HP:0100710)2.40348900
52Tubulointerstitial abnormality (HP:0001969)2.39197681
53Hepatic necrosis (HP:0002605)2.37400053
54Pancreatic fibrosis (HP:0100732)2.36238294
55Abnormal gallbladder physiology (HP:0012438)2.34599853
56Cholecystitis (HP:0001082)2.34599853
57Rib fusion (HP:0000902)2.31869099
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.31632454
59Medial flaring of the eyebrow (HP:0010747)2.30670392
60Azoospermia (HP:0000027)2.29542090
61Large for gestational age (HP:0001520)2.28511081
62Dicarboxylic aciduria (HP:0003215)2.27843042
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27843042
64Abnormality of the pons (HP:0007361)2.23432377
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18123020
66Abnormality of alanine metabolism (HP:0010916)2.18123020
67Hyperalaninemia (HP:0003348)2.18123020
68Increased intramyocellular lipid droplets (HP:0012240)2.12682914
69Progressive inability to walk (HP:0002505)2.12562767
70Hypothermia (HP:0002045)2.10800833
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10627251
72Colon cancer (HP:0003003)2.08763152
73Inability to walk (HP:0002540)2.08298672
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08136816
75Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08136816
76Tubulointerstitial fibrosis (HP:0005576)2.07557077
77Optic nerve hypoplasia (HP:0000609)2.06949688
78Hyperglycinemia (HP:0002154)2.06873535
79Chorioretinal atrophy (HP:0000533)2.05251790
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04184929
81Abnormality of renal resorption (HP:0011038)2.03943295
82Bony spicule pigmentary retinopathy (HP:0007737)2.03313665
83Abnormality of the lower motor neuron (HP:0002366)2.02499074
84Dynein arm defect of respiratory motile cilia (HP:0012255)13.2761215
85Absent/shortened dynein arms (HP:0200106)13.2761215
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2641374
87Dyschromatopsia (HP:0007641)1.99070193
88Chronic hepatic failure (HP:0100626)1.97836026
89Hypoplasia of the pons (HP:0012110)1.97219069
90Ketosis (HP:0001946)1.95148542
91Increased serum lactate (HP:0002151)1.94373287
92Severe visual impairment (HP:0001141)1.93541391
93Abnormality of vitamin B metabolism (HP:0004340)1.92891996
94Facial diplegia (HP:0001349)1.91231497
95Double outlet right ventricle (HP:0001719)1.90998424
96Congenital malformation of the right heart (HP:0011723)1.90998424
97Abolished electroretinogram (ERG) (HP:0000550)1.90961517
98Nephrogenic diabetes insipidus (HP:0009806)1.89125467
99Ketoacidosis (HP:0001993)1.86818979
100Lactic acidosis (HP:0003128)1.85631245
101Lissencephaly (HP:0001339)1.85548268
102Hyperventilation (HP:0002883)1.84867072
103Testicular atrophy (HP:0000029)1.83614569
104Duplicated collecting system (HP:0000081)1.83038578
105Congenital sensorineural hearing impairment (HP:0008527)1.81957965
106Hypomagnesemia (HP:0002917)1.81617619
107Severe muscular hypotonia (HP:0006829)1.81286367
108Polydipsia (HP:0001959)1.80862773
109Abnormal drinking behavior (HP:0030082)1.80862773
110Aplasia/Hypoplasia of the patella (HP:0006498)1.80637638
111Choroideremia (HP:0001139)1.80577332
112Patellar aplasia (HP:0006443)1.80392462
113Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78242287
114Fibular hypoplasia (HP:0003038)1.77759434
115Hyperphosphaturia (HP:0003109)1.77423407
116Amyotrophic lateral sclerosis (HP:0007354)1.76464528
117Ureteral duplication (HP:0000073)1.74860909
118Stage 5 chronic kidney disease (HP:0003774)1.74323667
119Abnormality of the renal collecting system (HP:0004742)1.74210553
120Spastic tetraparesis (HP:0001285)1.74168696
121Decreased central vision (HP:0007663)1.73617514
122Postaxial foot polydactyly (HP:0001830)1.73231890
123Generalized aminoaciduria (HP:0002909)1.73168423
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72807536
125Stomach cancer (HP:0012126)1.71635114
126Abnormality of the vitamin B12 metabolism (HP:0004341)1.71302782
127Hyperglycinuria (HP:0003108)1.70984147
128Gaze-evoked nystagmus (HP:0000640)1.70423748
129Neurofibrillary tangles (HP:0002185)1.69249937
130Absent thumb (HP:0009777)1.66727693
131Exercise-induced myalgia (HP:0003738)1.65850512
132Congenital hepatic fibrosis (HP:0002612)1.64360772
133Abnormality of renal excretion (HP:0011036)1.62800544
134Hemorrhage of the eye (HP:0011885)1.60842189
135Abnormality of the renal cortex (HP:0011035)1.56962606
136Oculomotor apraxia (HP:0000657)1.55164478
137Short ribs (HP:0000773)1.50997313
138Abnormal biliary tract physiology (HP:0012439)1.50736307
139Bile duct proliferation (HP:0001408)1.50736307
140Decreased electroretinogram (ERG) amplitude (HP:0000654)1.49122561
141Renal dysplasia (HP:0000110)1.45202203
142Abnormality of dentin (HP:0010299)1.45109105
143Aplasia/Hypoplasia of the lens (HP:0008063)1.44833584
144Heterotopia (HP:0002282)1.44346904
145Myoglobinuria (HP:0002913)1.44328107
146Impaired proprioception (HP:0010831)1.41940220
147Easy fatigability (HP:0003388)1.41753857
148Abnormality of permanent molar morphology (HP:0011071)1.41061265
149Abnormality of the dental root (HP:0006486)1.41061265
150Taurodontia (HP:0000679)1.41061265
151Facial cleft (HP:0002006)1.39841654
152Abnormal urine output (HP:0012590)1.37862275
153Postaxial hand polydactyly (HP:0001162)1.36863643
154Exercise-induced muscle cramps (HP:0003710)1.35989952
155Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.35046242
156Absent epiphyses (HP:0010577)1.35046242
157Deformed sella turcica (HP:0002681)1.34313370
158Cerebral inclusion bodies (HP:0100314)1.34270511
159Abnormality of the dental pulp (HP:0006479)1.32585545
160Bell-shaped thorax (HP:0001591)1.32106769
161Cystic liver disease (HP:0006706)1.32101889
162Asymmetric septal hypertrophy (HP:0001670)1.30691750
163Rhabdomyolysis (HP:0003201)1.30387192
164Cerebellar dysplasia (HP:0007033)1.30044811
165Chronic sinusitis (HP:0011109)1.29676679
166Loss of speech (HP:0002371)1.29231580
167Abnormality of molar morphology (HP:0011070)1.29043787
168Abnormality of molar (HP:0011077)1.29043787
169Broad distal phalanx of finger (HP:0009836)1.28557533
170Bundle branch block (HP:0011710)1.28181673
171Sensory axonal neuropathy (HP:0003390)1.21813715
172Constricted visual fields (HP:0001133)1.21734037
173Abnormality of the neuromuscular junction (HP:0003398)1.19994779
174Fatigable weakness (HP:0003473)1.19994779
175Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.19651343
176Short femoral neck (HP:0100864)1.19639163
177Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.16630490
178Polyuria (HP:0000103)1.16567813
179Abnormality of ocular smooth pursuit (HP:0000617)1.16364673
180Absent frontal sinuses (HP:0002688)1.16133115
181Nephropathy (HP:0000112)1.15709517
182Retinal dysplasia (HP:0007973)1.14037968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.31825602
2PDK48.31825602
3TESK16.34208853
4PDK25.37247482
5PRKD34.45967543
6ICK4.45572815
7TLK14.00738276
8ADRBK23.79157535
9FRK3.78852834
10ZAK3.55331206
11TAOK32.74692744
12ERN12.68362241
13MAPK132.66720608
14GRK12.38521272
15PTK2B2.33321835
16WNK42.24536742
17BMPR1B2.23041951
18STK392.18782931
19MAP4K22.08295144
20STK381.89507655
21ACVR1B1.89196756
22WNK31.79590044
23NEK21.78720809
24MST41.75278489
25MAP2K71.57993393
26DYRK1B1.53635870
27ADRBK11.49902656
28PNCK1.45337784
29INSRR1.45277275
30EIF2AK31.41002929
31BLK1.39957998
32TXK1.38637061
33VRK21.35561018
34VRK11.32281981
35PDK11.31055799
36CSNK1G31.30106162
37CSNK1A1L1.30057797
38NUAK11.29867850
39OXSR11.27745641
40DAPK21.25133105
41CAMKK21.17712803
42CSNK1G11.16390906
43DYRK21.09000922
44IKBKE1.05307186
45MAPKAPK31.03097143
46MAP2K40.99475028
47MAP2K20.98316201
48CSNK1G20.95472668
49DYRK30.92508016
50MAPK150.90914541
51IKBKB0.90240247
52CDK190.89301858
53CCNB10.86946463
54TIE10.86414416
55TYRO30.85204222
56PDPK10.84726237
57MAP2K10.84223906
58WNK10.83364288
59BCKDK0.82381617
60HIPK20.80667900
61IRAK10.79680788
62RIPK40.78746188
63PAK30.78604858
64PASK0.78573297
65EEF2K0.78488348
66PHKG20.77331682
67PHKG10.77331682
68GRK70.76188401
69NEK10.75101141
70SYK0.72253678
71STK30.70395439
72TBK10.70321202
73PINK10.70265888
74TNK20.69577812
75PIK3CG0.68842370
76NLK0.67901319
77MARK10.65354197
78TTK0.65184427
79RPS6KA50.63825090
80TESK20.63594410
81PRKCI0.62729049
82TEC0.56562962
83STK160.55520899
84TRIM280.54381349
85CHEK20.53043109
86NTRK20.49645512
87TGFBR10.49557332
88MUSK0.46737132
89MAP3K100.45760227
90CSNK1A10.43887475
91CDK80.43708016
92PRKCE0.43512587
93STK38L0.43302410
94BMPR20.40842197
95PRKCG0.40707226
96CHUK0.39737585
97PIM20.39214264
98NTRK30.37945863
99MAP2K60.37766833
100IRAK20.37150627
101CHEK10.36945131
102MELK0.36167744
103PAK10.35775781
104KDR0.34948844
105MAP4K10.34435937
106LMTK20.33929844
107PKN10.33427828
108MAPKAPK50.33356211
109TRPM70.33082791
110CASK0.32627649
111PLK20.32519134
112LYN0.30513286
113ATR0.29818798
114GRK60.29787942
115FLT30.29364014
116CAMKK10.28628722
117ITK0.28431557
118CDC70.27111937
119PAK40.25241517
120PAK20.25014632
121CAMK1G0.23654129
122ATM0.23615266
123WEE10.23435205
124MARK20.23426071
125PRKCZ0.20909356
126CDK150.20685523
127BRSK20.19662106
128MTOR0.19538942
129BRAF0.18628581
130CDK180.17848659
131PRKCQ0.17765991
132CDK11A0.16534495
133PRKAA10.15492429
134STK100.15365962
135CSF1R0.14207372
136PRKG20.14130284
137RPS6KB10.13496901
138PLK10.12643411
139CDK140.12349374
140BRSK10.11869299
141RPS6KA10.08740198
142CSNK2A10.07922386
143MARK30.07619509
144PRKACG0.04590155
145PRKCD0.04440792
146GSK3B0.03891498
147PIM10.03416560
148CLK10.03384829
149MAPK80.03349366
150TRIB30.03288612
151PLK40.02871034
152PRKG10.02563985
153STK110.02525995
154BUB10.02336356
155CDK10.01580284
156AURKA0.01176766
157CDK20.00785154
158PRKCB0.00750059
159PRKCA0.00717390
160PRKDC-0.0517103
161PRKACA-0.0501481
162CSK-0.0488809
163CSNK1D-0.0484682
164PRKACB-0.0364383
165RPS6KA3-0.0357711
166PDGFRB-0.0214716
167EGFR-0.0193652
168MAP3K4-0.0161110
169EPHB1-0.0149572
170CDK6-0.0110996
171ZAP70-0.0075990
172CSNK2A2-0.0036735
173CAMK2A-0.0029041
174PAK6-0.0025509
175NEK6-0.0004997

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.66692860
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.50741967
3Vitamin B6 metabolism_Homo sapiens_hsa007504.05517617
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.80227571
5Pyruvate metabolism_Homo sapiens_hsa006203.63345671
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.32963931
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.24091136
8Linoleic acid metabolism_Homo sapiens_hsa005913.14301061
9Propanoate metabolism_Homo sapiens_hsa006402.74976302
10Glucagon signaling pathway_Homo sapiens_hsa049222.73904144
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.60938376
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.58196371
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.49615511
14Sulfur relay system_Homo sapiens_hsa041222.43492308
15Basal transcription factors_Homo sapiens_hsa030222.31077300
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.23478339
17Oxidative phosphorylation_Homo sapiens_hsa001902.18912243
18Phototransduction_Homo sapiens_hsa047442.17071820
19Selenocompound metabolism_Homo sapiens_hsa004502.10512279
20RNA polymerase_Homo sapiens_hsa030202.06309552
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00622860
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.00385435
23Pentose phosphate pathway_Homo sapiens_hsa000301.93828064
24Glycerolipid metabolism_Homo sapiens_hsa005611.89605348
25PPAR signaling pathway_Homo sapiens_hsa033201.81518585
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79738864
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.78636796
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75573443
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.72537360
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71089190
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70900760
32Graft-versus-host disease_Homo sapiens_hsa053321.70701285
33Fat digestion and absorption_Homo sapiens_hsa049751.68260130
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.68136891
35Butanoate metabolism_Homo sapiens_hsa006501.66986527
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.65937176
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63009222
38Asthma_Homo sapiens_hsa053101.62429433
39Parkinsons disease_Homo sapiens_hsa050121.60711357
40Fructose and mannose metabolism_Homo sapiens_hsa000511.60145676
41Amphetamine addiction_Homo sapiens_hsa050311.58906448
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58573496
43Caffeine metabolism_Homo sapiens_hsa002321.56530196
44Nitrogen metabolism_Homo sapiens_hsa009101.55918336
45Oocyte meiosis_Homo sapiens_hsa041141.55582497
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.55372433
47Primary immunodeficiency_Homo sapiens_hsa053401.53139387
48Type I diabetes mellitus_Homo sapiens_hsa049401.52176232
49Allograft rejection_Homo sapiens_hsa053301.47764991
50Homologous recombination_Homo sapiens_hsa034401.46164553
51Carbon metabolism_Homo sapiens_hsa012001.44235460
52Ether lipid metabolism_Homo sapiens_hsa005651.43612244
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43264168
54Fatty acid degradation_Homo sapiens_hsa000711.42758063
55Fatty acid metabolism_Homo sapiens_hsa012121.41708361
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39972408
57Mineral absorption_Homo sapiens_hsa049781.37520709
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36181016
59Autoimmune thyroid disease_Homo sapiens_hsa053201.34696806
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.31669704
61Cardiac muscle contraction_Homo sapiens_hsa042601.31392076
62Tryptophan metabolism_Homo sapiens_hsa003801.30366297
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29042445
64Dorso-ventral axis formation_Homo sapiens_hsa043201.27998067
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.27241143
66Protein export_Homo sapiens_hsa030601.22286981
67Fanconi anemia pathway_Homo sapiens_hsa034601.19876873
68Renin secretion_Homo sapiens_hsa049241.14403666
69Alzheimers disease_Homo sapiens_hsa050101.13797726
70Olfactory transduction_Homo sapiens_hsa047401.10517116
71Proteasome_Homo sapiens_hsa030501.10205215
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09080523
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06300109
74Nicotine addiction_Homo sapiens_hsa050331.04930925
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04011485
76Glutathione metabolism_Homo sapiens_hsa004801.02527229
77Antigen processing and presentation_Homo sapiens_hsa046121.02361544
78Peroxisome_Homo sapiens_hsa041461.00976971
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00123952
80Ovarian steroidogenesis_Homo sapiens_hsa049130.99629998
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.97603806
82Biosynthesis of amino acids_Homo sapiens_hsa012300.94967936
83Purine metabolism_Homo sapiens_hsa002300.94852874
84Collecting duct acid secretion_Homo sapiens_hsa049660.93471977
85Huntingtons disease_Homo sapiens_hsa050160.89593964
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87591552
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87064497
88Chemical carcinogenesis_Homo sapiens_hsa052040.85680875
89Hedgehog signaling pathway_Homo sapiens_hsa043400.85390506
90Long-term potentiation_Homo sapiens_hsa047200.85279570
91Arachidonic acid metabolism_Homo sapiens_hsa005900.84344311
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82161640
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.81052523
94mRNA surveillance pathway_Homo sapiens_hsa030150.79434030
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77260699
96Sphingolipid metabolism_Homo sapiens_hsa006000.76286090
97Insulin secretion_Homo sapiens_hsa049110.72252840
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72112020
99Estrogen signaling pathway_Homo sapiens_hsa049150.72099151
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71842319
101Steroid biosynthesis_Homo sapiens_hsa001000.71732534
102One carbon pool by folate_Homo sapiens_hsa006700.70691236
103Rheumatoid arthritis_Homo sapiens_hsa053230.67656317
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66671267
105Ribosome_Homo sapiens_hsa030100.66347296
106Morphine addiction_Homo sapiens_hsa050320.66287307
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66040951
108RNA degradation_Homo sapiens_hsa030180.65878227
109Thyroid hormone synthesis_Homo sapiens_hsa049180.65784644
110Regulation of autophagy_Homo sapiens_hsa041400.65255504
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65245640
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.64847392
113Retinol metabolism_Homo sapiens_hsa008300.64659650
114Bile secretion_Homo sapiens_hsa049760.64600955
115Vitamin digestion and absorption_Homo sapiens_hsa049770.59490180
116RNA transport_Homo sapiens_hsa030130.58975661
117Systemic lupus erythematosus_Homo sapiens_hsa053220.58682347
118Base excision repair_Homo sapiens_hsa034100.58294062
119Legionellosis_Homo sapiens_hsa051340.57690329
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56830712
121ABC transporters_Homo sapiens_hsa020100.55260945
122Staphylococcus aureus infection_Homo sapiens_hsa051500.55108014
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54135243
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52709728
125Serotonergic synapse_Homo sapiens_hsa047260.52199502
126VEGF signaling pathway_Homo sapiens_hsa043700.51909938
127Pancreatic secretion_Homo sapiens_hsa049720.51653188
128Renin-angiotensin system_Homo sapiens_hsa046140.51150399
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50221219
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50188402
131GABAergic synapse_Homo sapiens_hsa047270.49404201
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.49106231
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47117878
134Salivary secretion_Homo sapiens_hsa049700.44611936
135AMPK signaling pathway_Homo sapiens_hsa041520.43623348
136Calcium signaling pathway_Homo sapiens_hsa040200.42517399
137Endocytosis_Homo sapiens_hsa041440.40478263
138Synaptic vesicle cycle_Homo sapiens_hsa047210.39119445
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36976619
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35466568
141Metabolic pathways_Homo sapiens_hsa011000.35009268
142Hematopoietic cell lineage_Homo sapiens_hsa046400.34885022
143Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33802197
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.33782354
145Sulfur metabolism_Homo sapiens_hsa009200.33713961
146Gastric acid secretion_Homo sapiens_hsa049710.33071656
147Protein digestion and absorption_Homo sapiens_hsa049740.31775837
148Pyrimidine metabolism_Homo sapiens_hsa002400.31530537
149Alcoholism_Homo sapiens_hsa050340.30645858
150B cell receptor signaling pathway_Homo sapiens_hsa046620.28794214
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25869725
152Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25298332
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24670526
154Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24063888
155Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23753096
156NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23629661
157cAMP signaling pathway_Homo sapiens_hsa040240.21331172
158Inositol phosphate metabolism_Homo sapiens_hsa005620.20488702
159Salmonella infection_Homo sapiens_hsa051320.17045300
160Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16803052
161Cocaine addiction_Homo sapiens_hsa050300.14924502
162Wnt signaling pathway_Homo sapiens_hsa043100.13435579
163HIF-1 signaling pathway_Homo sapiens_hsa040660.13182846
164Circadian entrainment_Homo sapiens_hsa047130.12313545
165Viral carcinogenesis_Homo sapiens_hsa052030.07373868
166N-Glycan biosynthesis_Homo sapiens_hsa005100.06691555
167Glutamatergic synapse_Homo sapiens_hsa047240.04286181
168Taste transduction_Homo sapiens_hsa047420.04068011

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