HSPBAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds to one of the small heat shock proteins, specifically hsp27. Hsp27 is involved with cell growth and differentiation. This encoded protein was found to be abnormally expressed in patients with intractable epilepsy, although how brain function is affected remains unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.51202151
2regulation of gene silencing by RNA (GO:0060966)4.50483736
3regulation of posttranscriptional gene silencing (GO:0060147)4.50483736
4regulation of gene silencing by miRNA (GO:0060964)4.50483736
5regulation of B cell receptor signaling pathway (GO:0050855)4.47323244
6DNA replication initiation (GO:0006270)4.41745656
7neutrophil activation involved in immune response (GO:0002283)4.34263929
8nuclear pore organization (GO:0006999)4.30181549
9DNA replication checkpoint (GO:0000076)4.25495216
10positive regulation of gamma-delta T cell activation (GO:0046645)4.19143065
11DNA strand elongation involved in DNA replication (GO:0006271)4.17865049
12nucleobase biosynthetic process (GO:0046112)4.17827545
13formation of translation preinitiation complex (GO:0001731)4.08297034
14mitotic nuclear envelope disassembly (GO:0007077)4.08066177
15DNA replication-dependent nucleosome assembly (GO:0006335)4.07852993
16DNA replication-dependent nucleosome organization (GO:0034723)4.07852993
17protein localization to kinetochore (GO:0034501)4.04620663
18folic acid-containing compound biosynthetic process (GO:0009396)4.01921829
19purine nucleobase biosynthetic process (GO:0009113)4.00741591
20DNA strand elongation (GO:0022616)3.99053591
21nuclear pore complex assembly (GO:0051292)3.98377018
22regulation of helicase activity (GO:0051095)3.92322639
23ribosome biogenesis (GO:0042254)3.90396238
24IMP biosynthetic process (GO:0006188)3.89872765
25DNA unwinding involved in DNA replication (GO:0006268)3.89291148
26ribosome assembly (GO:0042255)3.85757196
27activated T cell proliferation (GO:0050798)3.80322123
28telomere maintenance via semi-conservative replication (GO:0032201)3.79275122
29metaphase plate congression (GO:0051310)3.78095258
30nuclear envelope disassembly (GO:0051081)3.77765273
31membrane disassembly (GO:0030397)3.77765273
32somatic hypermutation of immunoglobulin genes (GO:0016446)3.76533829
33somatic diversification of immune receptors via somatic mutation (GO:0002566)3.76533829
34maturation of SSU-rRNA (GO:0030490)3.75487228
35detection of molecule of bacterial origin (GO:0032490)3.69669080
36neutrophil activation (GO:0042119)3.66036209
37negative regulation of cell killing (GO:0031342)3.60069677
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.60069677
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59604729
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.59604729
41modulation by symbiont of host immune response (GO:0052553)3.59604729
42positive regulation by symbiont of host defense response (GO:0052509)3.59604729
43modulation by symbiont of host defense response (GO:0052031)3.59604729
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59604729
45regulation of nuclear cell cycle DNA replication (GO:0033262)3.58411346
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.55300378
47chromatin remodeling at centromere (GO:0031055)3.54934959
48negative regulation of interleukin-12 production (GO:0032695)3.54180012
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.51365225
50kinetochore organization (GO:0051383)3.51172002
51mitotic sister chromatid segregation (GO:0000070)3.49485498
52telomere maintenance via recombination (GO:0000722)3.48405897
53neural tube formation (GO:0001841)3.48190619
54protein K11-linked deubiquitination (GO:0035871)3.48022068
55microglial cell activation (GO:0001774)3.47682309
56ribonucleoprotein complex biogenesis (GO:0022613)3.46492653
57kinetochore assembly (GO:0051382)3.46008103
58positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.44598621
59establishment of chromosome localization (GO:0051303)3.42365573
60protein localization to chromosome, centromeric region (GO:0071459)3.41992090
61CENP-A containing nucleosome assembly (GO:0034080)3.41768288
62protein K6-linked ubiquitination (GO:0085020)3.39539540
63mitotic recombination (GO:0006312)3.35301317
64macrophage activation involved in immune response (GO:0002281)3.33686179
65telomere maintenance via telomere lengthening (GO:0010833)3.30740833
66regulation of spindle organization (GO:0090224)3.29691258
67regulation of mast cell activation (GO:0033003)3.29298202
68IMP metabolic process (GO:0046040)3.28234050
69positive regulation of mast cell activation (GO:0033005)3.27242429
70ribosomal large subunit biogenesis (GO:0042273)3.25537769
71regulation of double-strand break repair via homologous recombination (GO:0010569)3.25358137
72response to peptidoglycan (GO:0032494)3.23950968
73DNA replication-independent nucleosome assembly (GO:0006336)3.22227267
74DNA replication-independent nucleosome organization (GO:0034724)3.22227267
75attachment of spindle microtubules to kinetochore (GO:0008608)3.21803744
76pore complex assembly (GO:0046931)3.21621496
77neutrophil mediated immunity (GO:0002446)3.19084929
78granulocyte activation (GO:0036230)3.18607625
79meiotic chromosome segregation (GO:0045132)3.17903471
80spliceosomal snRNP assembly (GO:0000387)3.16427902
81positive regulation of chromosome segregation (GO:0051984)3.15396410
82regulation of centrosome cycle (GO:0046605)3.14014229
83regulation of memory T cell differentiation (GO:0043380)3.13889047
84regulation of gamma-delta T cell activation (GO:0046643)3.12574240
85DNA duplex unwinding (GO:0032508)3.12488054
86rRNA modification (GO:0000154)3.12452474
87DNA geometric change (GO:0032392)3.12390174
88rRNA processing (GO:0006364)3.12162214
89heterochromatin organization (GO:0070828)3.11868598
90nucleotide-excision repair, DNA gap filling (GO:0006297)3.11049624
91cellular extravasation (GO:0045123)3.10172362
92regulation of mitotic spindle organization (GO:0060236)3.08921545
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.07015047
94myeloid cell activation involved in immune response (GO:0002275)3.06049519
95mismatch repair (GO:0006298)3.05198343
96negative regulation of chromosome segregation (GO:0051985)3.04275327
97mitotic chromosome condensation (GO:0007076)3.03782492
98rRNA metabolic process (GO:0016072)3.02710957
99sister chromatid segregation (GO:0000819)3.02700838
100immunoglobulin mediated immune response (GO:0016064)3.01959935
101interferon-gamma production (GO:0032609)3.01813856
102detection of external biotic stimulus (GO:0098581)3.01672405
103transcription-coupled nucleotide-excision repair (GO:0006283)3.00235548
104histone exchange (GO:0043486)2.99280109
105DNA deamination (GO:0045006)2.99169036
106maturation of 5.8S rRNA (GO:0000460)2.97724224
107regulation of histone H3-K9 methylation (GO:0051570)2.96584837
108negative regulation of sister chromatid segregation (GO:0033046)2.94336546
109negative regulation of mitotic sister chromatid separation (GO:2000816)2.94336546
110negative regulation of mitotic sister chromatid segregation (GO:0033048)2.94336546
111negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.94336546
112positive regulation of mast cell activation involved in immune response (GO:0033008)2.93378142
113positive regulation of mast cell degranulation (GO:0043306)2.93378142
114detection of other organism (GO:0098543)2.91650744
115macrophage activation (GO:0042116)2.90700167
116positive regulation of interleukin-1 beta secretion (GO:0050718)2.90475084
117mast cell activation (GO:0045576)2.90397535
118regulation of chromosome segregation (GO:0051983)2.89773343
119establishment of integrated proviral latency (GO:0075713)2.89740437
120spindle checkpoint (GO:0031577)2.89733849
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89590340
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89589700
123regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88740940
124negative regulation of mast cell activation (GO:0033004)2.88524332
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88246666
126negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87307652
127paraxial mesoderm development (GO:0048339)2.86857925
128regulation of telomere maintenance via telomerase (GO:0032210)2.86741924
129cellular response to interleukin-15 (GO:0071350)2.86072767
130nuclear envelope organization (GO:0006998)2.85950315
131negative regulation of lymphocyte mediated immunity (GO:0002707)2.85512817
132negative regulation of interleukin-1 production (GO:0032692)2.85414968
133histone H4-K12 acetylation (GO:0043983)2.84974217
134histone arginine methylation (GO:0034969)2.84679557
135negative regulation of T-helper cell differentiation (GO:0045623)2.84594194
136negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.84594194
137transcription from RNA polymerase I promoter (GO:0006360)2.84475294
138regulation of regulatory T cell differentiation (GO:0045589)2.84360435
139spindle assembly checkpoint (GO:0071173)2.83878607
140pre-miRNA processing (GO:0031054)2.83625773
141proteasome assembly (GO:0043248)2.83499872
142regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.83436695
143mitotic spindle assembly checkpoint (GO:0007094)2.82722799
144regulation of gene silencing (GO:0060968)2.82639273
145negative regulation of T cell mediated immunity (GO:0002710)2.82286266
146regulation of centriole replication (GO:0046599)2.81954185
147positive regulation of mitotic sister chromatid separation (GO:1901970)2.81819954
148positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.81819954
149positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.81819954
150myeloid leukocyte mediated immunity (GO:0002444)2.80477804
151positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.80319966
152negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.80003893
153regulation of gamma-delta T cell differentiation (GO:0045586)2.78946673
154leukocyte degranulation (GO:0043299)2.77732335
155negative regulation of interleukin-1 beta production (GO:0032691)2.77230523
156regulation of interleukin-6 biosynthetic process (GO:0045408)2.76642530
157RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76379504
158regulation of interferon-beta biosynthetic process (GO:0045357)2.76211856
159defense response to protozoan (GO:0042832)2.75531270
160regulation of interleukin-1 beta secretion (GO:0050706)2.75110710
161regulation of germinal center formation (GO:0002634)2.74521087
162antigen processing and presentation of endogenous antigen (GO:0019883)2.74276025
163positive regulation of interleukin-1 secretion (GO:0050716)2.70221151
164negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.69173096
165response to interleukin-15 (GO:0070672)2.69074131
166leukocyte migration involved in inflammatory response (GO:0002523)2.68939013
167detection of biotic stimulus (GO:0009595)2.67702191
168piRNA metabolic process (GO:0034587)2.66432449
169regulation of MHC class II biosynthetic process (GO:0045346)2.65284626
170regulation of alpha-beta T cell proliferation (GO:0046640)2.63370379
171detection of bacterium (GO:0016045)2.62580589
172negative thymic T cell selection (GO:0045060)2.62054243
173rRNA catabolic process (GO:0016075)2.61081100
174mast cell activation involved in immune response (GO:0002279)2.60971710
175mast cell degranulation (GO:0043303)2.60971710
176negative T cell selection (GO:0043383)2.59431883
177positive regulation of toll-like receptor signaling pathway (GO:0034123)2.57827065
178negative regulation of cAMP-mediated signaling (GO:0043951)2.57674256
179positive regulation of antigen processing and presentation (GO:0002579)2.55414929
180regulation of mast cell activation involved in immune response (GO:0033006)2.55135504
181dendritic cell migration (GO:0036336)2.54681513
182response to host immune response (GO:0052572)2.53611969
183response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.53611969
184regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.53131409
185regulation of hypersensitivity (GO:0002883)2.50665536
186B cell receptor signaling pathway (GO:0050853)2.49988471
187negative regulation of adaptive immune response (GO:0002820)2.49339517
188respiratory burst (GO:0045730)2.48913473
189tolerance induction (GO:0002507)2.48003147
190protein K63-linked deubiquitination (GO:0070536)2.45090763
191phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.44881797
192B cell mediated immunity (GO:0019724)2.42285797
193positive regulation of alpha-beta T cell proliferation (GO:0046641)2.41931242
194hepatocyte apoptotic process (GO:0097284)2.41206905
195regulation of antigen processing and presentation (GO:0002577)2.40649602
196positive regulation of granulocyte differentiation (GO:0030854)2.40277245
197regulation of mast cell degranulation (GO:0043304)2.40079378
198regulation of B cell differentiation (GO:0045577)2.39942128
199response to protozoan (GO:0001562)2.39310902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.54406627
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.11421648
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.77670452
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.61572882
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50785594
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.13640689
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.08410610
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.04942382
9ZNF274_21170338_ChIP-Seq_K562_Hela2.99762517
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91592305
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81520094
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80688782
13IGF1R_20145208_ChIP-Seq_DFB_Human2.70235096
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66248471
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64769355
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.61384442
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.54525960
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.54525960
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.54525960
20VDR_22108803_ChIP-Seq_LS180_Human2.53474815
21GBX2_23144817_ChIP-Seq_PC3_Human2.46506011
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39713762
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.39315238
24NANOG_18555785_ChIP-Seq_MESCs_Mouse2.38731883
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.38293827
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.37692506
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35571355
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.32200788
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31516632
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.27408081
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24144181
32POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23603387
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.22716296
34CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21980964
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17639103
36* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16970310
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11544090
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10722693
39RUNX_20019798_ChIP-Seq_JUKART_Human2.07672245
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05414819
41XRN2_22483619_ChIP-Seq_HELA_Human2.03701968
42ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03192598
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00912159
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.00144613
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98098024
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98011246
47TAF15_26573619_Chip-Seq_HEK293_Human1.92161701
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91289559
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.87946703
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.85698599
51VDR_23849224_ChIP-Seq_CD4+_Human1.85458698
52AR_21909140_ChIP-Seq_LNCAP_Human1.84036267
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83711550
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82536179
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.82387575
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.81344545
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81234210
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.80929337
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79402123
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.76138971
61* E2F1_21310950_ChIP-Seq_MCF-7_Human1.75934237
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.75900134
63GATA3_26560356_Chip-Seq_TH2_Human1.74064949
64P300_19829295_ChIP-Seq_ESCs_Human1.67096452
65DCP1A_22483619_ChIP-Seq_HELA_Human1.66959395
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62557660
67ER_23166858_ChIP-Seq_MCF-7_Human1.62439994
68* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59674372
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.58381405
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58196436
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.57894276
72TTF2_22483619_ChIP-Seq_HELA_Human1.57660713
73* FOXP3_21729870_ChIP-Seq_TREG_Human1.57598894
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.57353723
75MYB_26560356_Chip-Seq_TH2_Human1.56303282
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56270519
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56178835
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56112938
79EWS_26573619_Chip-Seq_HEK293_Human1.53853608
80GABP_19822575_ChIP-Seq_HepG2_Human1.52110616
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.52014191
82VDR_24787735_ChIP-Seq_THP-1_Human1.51411548
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.50700110
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49332819
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48045541
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47963805
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46946144
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.46726708
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45444596
90BCAT_22108803_ChIP-Seq_LS180_Human1.45438171
91* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44975405
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43568706
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41971188
94ELK1_19687146_ChIP-ChIP_HELA_Human1.41540692
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40558403
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40518496
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40408138
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39015498
99CBP_20019798_ChIP-Seq_JUKART_Human1.38748956
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38748956
101SCL_19346495_ChIP-Seq_HPC-7_Human1.38174191
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37608427
103* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37238914
104GATA3_27048872_Chip-Seq_THYMUS_Human1.36956942
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.36325638
106ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35628409
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34756852
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34430726
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33975082
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.33103884
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32707489
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32707489
113SPI1_23547873_ChIP-Seq_NB4_Human1.32225395
114SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31348604
115FUS_26573619_Chip-Seq_HEK293_Human1.31194585
116* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27281459
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27160463
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.27156161
119STAT3_23295773_ChIP-Seq_U87_Human1.26572610
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26329023
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26012522
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25589297
123KDM5A_27292631_Chip-Seq_BREAST_Human1.25466267
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24470376
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.24436524
126TCF4_23295773_ChIP-Seq_U87_Human1.22866469
127SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22564660
128SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21543403
129* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21095339
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20761858
131TP53_22573176_ChIP-Seq_HFKS_Human1.20034549
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.19934706
133CIITA_25753668_ChIP-Seq_RAJI_Human1.19897599
134NANOG_19829295_ChIP-Seq_ESCs_Human1.18198496
135SOX2_19829295_ChIP-Seq_ESCs_Human1.18198496
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17621235
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17370756
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16667326
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16440696
140SMRT_27268052_Chip-Seq_Bcells_Human1.16299344
141SMAD4_21799915_ChIP-Seq_A2780_Human1.16059334
142OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14757901
143RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13322036
144IRF1_19129219_ChIP-ChIP_H3396_Human1.13247642
145CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13193956
146AR_25329375_ChIP-Seq_VCAP_Human1.13012332
147FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12960968
148OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12843611
149NANOG_21062744_ChIP-ChIP_HESCs_Human1.12680008
150SRF_21415370_ChIP-Seq_HL-1_Mouse1.12062844
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12000686
152Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11813716
153* TFEB_21752829_ChIP-Seq_HELA_Human1.10953932
154ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10915330
155MYC_22102868_ChIP-Seq_BL_Human1.10480898
156NANOG_18692474_ChIP-Seq_MEFs_Mouse1.09622558
157FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08418251
158FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08388631
159SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08174668
160* GATA3_26560356_Chip-Seq_TH1_Human1.08072099
161SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07829898
162NANOG_18555785_Chip-Seq_ESCs_Mouse1.07259432
163SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06397281
164NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05695277
165MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05666961
166PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05172648
167RUNX2_22187159_ChIP-Seq_PCA_Human1.04906439
168FOXA1_25329375_ChIP-Seq_VCAP_Human1.04431893
169FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04431893
170TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04371732
171OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04239171
172HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03824081
173P53_22387025_ChIP-Seq_ESCs_Mouse1.03550951
174EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03211005
175SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01983746
176POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.01472694
177SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01275344
178TCF4_22108803_ChIP-Seq_LS180_Human1.00984749
179GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.00218420
180TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99919118
181E2F1_18555785_Chip-Seq_ESCs_Mouse0.99636365
182SMAD4_21741376_ChIP-Seq_EPCs_Human0.99210750
183GATA3_21878914_ChIP-Seq_MCF-7_Human0.98476557
184DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98073842
185* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97424903
186ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95611214
187NANOG_18692474_ChIP-Seq_MESCs_Mouse0.95042530
188PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94001291
189POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93485047
190TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93094382
191E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89480098
192* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89253118
193KAP1_27257070_Chip-Seq_ESCs_Mouse0.89139315
194ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88864271
195NOTCH1_21737748_ChIP-Seq_TLL_Human0.87482613
196CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83965905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.88161886
2MP0010094_abnormal_chromosome_stability4.46652783
3MP0003111_abnormal_nucleus_morphology4.43712104
4MP0008057_abnormal_DNA_replication4.42258817
5MP0004957_abnormal_blastocyst_morpholog4.33707923
6MP0003724_increased_susceptibility_to4.32462065
7MP0003077_abnormal_cell_cycle3.83105108
8MP0008058_abnormal_DNA_repair3.48270055
9MP0001835_abnormal_antigen_presentation3.46726230
10MP0000569_abnormal_digit_pigmentation3.18135555
11MP0005671_abnormal_response_to2.84741140
12MP0001800_abnormal_humoral_immune2.64119688
13MP0008932_abnormal_embryonic_tissue2.62225470
14MP0003123_paternal_imprinting2.59754608
15MP0010352_gastrointestinal_tract_polyps2.58512536
16MP0003806_abnormal_nucleotide_metabolis2.55176320
17MP0008007_abnormal_cellular_replicative2.49447359
18MP0001730_embryonic_growth_arrest2.40107935
19MP0006082_CNS_inflammation2.36078736
20MP0000350_abnormal_cell_proliferation2.33495578
21MP0002148_abnormal_hypersensitivity_rea2.32363026
22MP0002653_abnormal_ependyma_morphology2.31505388
23MP0003436_decreased_susceptibility_to2.30438392
24MP0002419_abnormal_innate_immunity2.29513216
25MP0005000_abnormal_immune_tolerance2.25258238
26MP0005387_immune_system_phenotype2.25245556
27MP0001790_abnormal_immune_system2.25245556
28MP0000685_abnormal_immune_system2.25058777
29MP0009785_altered_susceptibility_to2.23928840
30MP0002723_abnormal_immune_serum2.23362687
31MP0008877_abnormal_DNA_methylation2.20345480
32MP0002452_abnormal_antigen_presenting2.15806352
33MP0009764_decreased_sensitivity_to2.12623898
34MP0004133_heterotaxia2.06353442
35MP0003786_premature_aging2.05798436
36MP0003941_abnormal_skin_development2.03962085
37MP0005451_abnormal_body_composition2.03311471
38MP0005075_abnormal_melanosome_morpholog2.01850100
39MP0002420_abnormal_adaptive_immunity2.00325962
40MP0010307_abnormal_tumor_latency1.98770579
41MP0001819_abnormal_immune_cell1.98586066
42MP0005025_abnormal_response_to1.98335139
43MP0003195_calcinosis1.95014212
44MP0003646_muscle_fatigue1.92302426
45MP0003718_maternal_effect1.90611946
46MP0005380_embryogenesis_phenotype1.86550876
47MP0001672_abnormal_embryogenesis/_devel1.86550876
48MP0003890_abnormal_embryonic-extraembry1.84445622
49MP0005310_abnormal_salivary_gland1.82145482
50MP0001986_abnormal_taste_sensitivity1.80474420
51MP0001697_abnormal_embryo_size1.70755652
52MP0002085_abnormal_embryonic_tissue1.70488745
53MP0003303_peritoneal_inflammation1.67778937
54MP0002084_abnormal_developmental_patter1.63282432
55MP0005076_abnormal_cell_differentiation1.60036639
56MP0003984_embryonic_growth_retardation1.58997192
57MP0002405_respiratory_system_inflammati1.56531903
58MP0002088_abnormal_embryonic_growth/wei1.56057305
59MP0002086_abnormal_extraembryonic_tissu1.52800316
60MP0002080_prenatal_lethality1.51758602
61MP0004197_abnormal_fetal_growth/weight/1.51460959
62MP0000716_abnormal_immune_system1.48932310
63MP0003763_abnormal_thymus_physiology1.48180406
64MP0000015_abnormal_ear_pigmentation1.48125798
65MP0000490_abnormal_crypts_of1.45767096
66MP0001293_anophthalmia1.44369677
67MP0002102_abnormal_ear_morphology1.42750949
68MP0005174_abnormal_tail_pigmentation1.41938496
69MP0002138_abnormal_hepatobiliary_system1.41218303
70MP0003119_abnormal_digestive_system1.39028560
71MP0000313_abnormal_cell_death1.39025414
72MP0006292_abnormal_olfactory_placode1.36934493
73MP0002210_abnormal_sex_determination1.35877088
74MP0001845_abnormal_inflammatory_respons1.33537897
75MP0002019_abnormal_tumor_incidence1.32385564
76MP0003787_abnormal_imprinting1.28281110
77MP0004381_abnormal_hair_follicle1.24868300
78MP0000465_gastrointestinal_hemorrhage1.24540916
79MP0003121_genomic_imprinting1.20216072
80MP0003183_abnormal_peptide_metabolism1.20015368
81MP0000516_abnormal_urinary_system1.19983860
82MP0005367_renal/urinary_system_phenotyp1.19983860
83MP0001145_abnormal_male_reproductive1.18621777
84MP0010155_abnormal_intestine_physiology1.18116631
85MP0005551_abnormal_eye_electrophysiolog1.17599482
86MP0008872_abnormal_physiological_respon1.16721898
87MP0004142_abnormal_muscle_tone1.16660604
88MP0008469_abnormal_protein_level1.16195928
89MP0002396_abnormal_hematopoietic_system1.15964811
90MP0001533_abnormal_skeleton_physiology1.13218627
91MP0000427_abnormal_hair_cycle1.13154396
92MP0002095_abnormal_skin_pigmentation1.09560055
93MP0003186_abnormal_redox_activity1.08906484
94MP0003566_abnormal_cell_adhesion1.08881010
95MP0005253_abnormal_eye_physiology1.08276847
96MP0010030_abnormal_orbit_morphology1.07894159
97MP0003315_abnormal_perineum_morphology1.06075127
98MP0003567_abnormal_fetal_cardiomyocyte1.05888569
99MP0003828_pulmonary_edema1.05462279
100MP0001929_abnormal_gametogenesis0.98324432
101MP0009333_abnormal_splenocyte_physiolog0.98298297
102MP0000653_abnormal_sex_gland0.98021719
103MP0000372_irregular_coat_pigmentation0.97755402
104MP0003705_abnormal_hypodermis_morpholog0.97580723
105MP0001501_abnormal_sleep_pattern0.96233276
106MP0005464_abnormal_platelet_physiology0.96051195
107MP0000858_altered_metastatic_potential0.94635298
108MP0004484_altered_response_of0.93283035
109MP0003172_abnormal_lysosome_physiology0.93206382
110MP0002160_abnormal_reproductive_system0.92929495
111MP0001119_abnormal_female_reproductive0.92880044
112MP0001286_abnormal_eye_development0.89866709
113MP0008875_abnormal_xenobiotic_pharmacok0.89433980
114MP0006072_abnormal_retinal_apoptosis0.89284017
115MP0002111_abnormal_tail_morphology0.87571649
116MP0005389_reproductive_system_phenotype0.87392725
117MP0002009_preneoplasia0.87209239
118MP0002166_altered_tumor_susceptibility0.87150948
119MP0005023_abnormal_wound_healing0.86409840
120MP0003448_altered_tumor_morphology0.86338238
121MP0001486_abnormal_startle_reflex0.85626604
122MP0003283_abnormal_digestive_organ0.84912590
123MP0005384_cellular_phenotype0.83587312
124MP0005266_abnormal_metabolism0.83360650
125MP0003866_abnormal_defecation0.82747802
126MP0005621_abnormal_cell_physiology0.82585847
127MP0005397_hematopoietic_system_phenotyp0.82567313
128MP0001545_abnormal_hematopoietic_system0.82567313
129MP0004264_abnormal_extraembryonic_tissu0.79856853
130MP0000358_abnormal_cell_content/0.79481919
131MP0003936_abnormal_reproductive_system0.79137594
132MP0009765_abnormal_xenobiotic_induced0.78009224
133MP0001849_ear_inflammation0.77607179
134MP0002277_abnormal_respiratory_mucosa0.77463728
135MP0009053_abnormal_anal_canal0.77445087
136MP0008260_abnormal_autophagy0.77158403
137MP0002933_joint_inflammation0.76888109
138MP0002006_tumorigenesis0.76693621
139MP0002132_abnormal_respiratory_system0.76382021
140MP0003136_yellow_coat_color0.76336210
141MP0003300_gastrointestinal_ulcer0.74322261
142MP0001851_eye_inflammation0.73415958
143MP0005167_abnormal_blood-brain_barrier0.73028714
144MP0005410_abnormal_fertilization0.72664985
145MP0000703_abnormal_thymus_morphology0.72340539
146MP0003221_abnormal_cardiomyocyte_apopto0.71932075
147MP0001324_abnormal_eye_pigmentation0.71914138
148MP0004883_abnormal_blood_vessel0.71387803
149MP0003937_abnormal_limbs/digits/tail_de0.70541919
150MP0002722_abnormal_immune_system0.70271738
151MP0003252_abnormal_bile_duct0.70177702
152MP0000371_diluted_coat_color0.69628622
153MP0000627_abnormal_mammary_gland0.68513452
154MP0001873_stomach_inflammation0.68386221
155MP0002398_abnormal_bone_marrow0.68384282
156MP0001968_abnormal_touch/_nociception0.67874698
157MP0009046_muscle_twitch0.67561276
158MP0005395_other_phenotype0.67378228
159MP0000689_abnormal_spleen_morphology0.67088568
160MP0004947_skin_inflammation0.65692417
161MP0003011_delayed_dark_adaptation0.65498408
162MP0002697_abnormal_eye_size0.65152026
163MP0001919_abnormal_reproductive_system0.64693930
164MP0005501_abnormal_skin_physiology0.64686641
165MP0002092_abnormal_eye_morphology0.64564257
166MP0001915_intracranial_hemorrhage0.63909739
167MP0000432_abnormal_head_morphology0.63539163
168MP0009278_abnormal_bone_marrow0.63163793
169MP0004808_abnormal_hematopoietic_stem0.63091529
170MP0001853_heart_inflammation0.62925076
171MP0000230_abnormal_systemic_arterial0.62012609
172MP0002928_abnormal_bile_duct0.60649229
173MP0009703_decreased_birth_body0.60562255
174MP0005377_hearing/vestibular/ear_phenot0.60466417
175MP0003878_abnormal_ear_physiology0.60466417
176MP0001348_abnormal_lacrimal_gland0.57109857
177MP0002429_abnormal_blood_cell0.56835653
178MP0000477_abnormal_intestine_morphology0.56209287
179MP0002332_abnormal_exercise_endurance0.55988278
180MP0009672_abnormal_birth_weight0.55948525
181MP0003698_abnormal_male_reproductive0.53518450
182MP0000537_abnormal_urethra_morphology0.53304846
183MP0003950_abnormal_plasma_membrane0.51861291
184MP0002127_abnormal_cardiovascular_syste0.51815667

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.44269929
2Birth length less than 3rd percentile (HP:0003561)4.75946633
3Chromsome breakage (HP:0040012)4.16737189
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.15189520
5Breast hypoplasia (HP:0003187)4.11595393
6Ependymoma (HP:0002888)4.06560575
7Optic neuritis (HP:0100653)3.81866056
8Retrobulbar optic neuritis (HP:0100654)3.81866056
9Absent radius (HP:0003974)3.79565233
10Recurrent abscess formation (HP:0002722)3.73475375
11Myositis (HP:0100614)3.63492037
12Abnormality of the labia minora (HP:0012880)3.58512630
13Absent forearm bone (HP:0003953)3.56483876
14Aplasia involving forearm bones (HP:0009822)3.56483876
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.52843559
16Supernumerary spleens (HP:0009799)3.52263208
17Selective tooth agenesis (HP:0001592)3.49590378
18Recurrent bacterial skin infections (HP:0005406)3.46848438
19Agnosia (HP:0010524)3.46319209
20Carpal bone hypoplasia (HP:0001498)3.43766860
21Patellar aplasia (HP:0006443)3.42722572
22Orchitis (HP:0100796)3.41033427
23Medulloblastoma (HP:0002885)3.34865913
24Meckel diverticulum (HP:0002245)3.30098045
25Reticulocytopenia (HP:0001896)3.26607926
26Abnormality of the ileum (HP:0001549)3.24692322
27Elevated erythrocyte sedimentation rate (HP:0003565)3.20714644
28Absent thumb (HP:0009777)3.20293548
29Aplasia/Hypoplasia of the patella (HP:0006498)3.15721910
30Colon cancer (HP:0003003)3.11808732
31Recurrent fungal infections (HP:0002841)3.10062458
32Abnormality of chromosome stability (HP:0003220)3.08463564
33Chronic mucocutaneous candidiasis (HP:0002728)3.07476834
34Recurrent cutaneous fungal infections (HP:0011370)3.07476834
35Aplasia/Hypoplasia of the uvula (HP:0010293)3.06998100
36Oral leukoplakia (HP:0002745)3.05287311
37Abnormality of the preputium (HP:0100587)3.01548944
38Pancreatic cysts (HP:0001737)3.00253885
39Impulsivity (HP:0100710)3.00145351
40Stomach cancer (HP:0012126)2.99693418
41Rough bone trabeculation (HP:0100670)2.98697165
42Abnormality of the anterior horn cell (HP:0006802)2.94674752
43Degeneration of anterior horn cells (HP:0002398)2.94674752
44Aplasia/hypoplasia of the humerus (HP:0006507)2.92479646
45Abnormality of T cell number (HP:0011839)2.91527515
46Cerebral hypomyelination (HP:0006808)2.89855716
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.86866209
48Keratoconjunctivitis (HP:0001096)2.85251678
49Encephalitis (HP:0002383)2.85131047
50Keratoconjunctivitis sicca (HP:0001097)2.82686858
51Recurrent gram-negative bacterial infections (HP:0005420)2.81561224
52Abnormality of abdominal situs (HP:0011620)2.78886376
53Abdominal situs inversus (HP:0003363)2.78886376
54Rib fusion (HP:0000902)2.78210055
55Astrocytoma (HP:0009592)2.77780157
56Abnormality of the astrocytes (HP:0100707)2.77780157
57Abolished electroretinogram (ERG) (HP:0000550)2.76944631
58Rhabdomyosarcoma (HP:0002859)2.74518505
59Congenital stationary night blindness (HP:0007642)2.73317386
60T lymphocytopenia (HP:0005403)2.72738353
61Panhypogammaglobulinemia (HP:0003139)2.70246890
62Abnormality of T cells (HP:0002843)2.69939909
63Neoplasm of the oral cavity (HP:0100649)2.66580245
64Abnormality of midbrain morphology (HP:0002418)2.63002972
65Molar tooth sign on MRI (HP:0002419)2.63002972
66Mediastinal lymphadenopathy (HP:0100721)2.62220279
67Recurrent skin infections (HP:0001581)2.60453702
68Cleft eyelid (HP:0000625)2.58738061
69Leukocytosis (HP:0001974)2.57933805
70Gastrointestinal infarctions (HP:0005244)2.57033719
71Duplicated collecting system (HP:0000081)2.54703260
72Abnormality of T cell physiology (HP:0011840)2.54277013
73Abnormal number of incisors (HP:0011064)2.53818240
74Pancreatic fibrosis (HP:0100732)2.52536828
75Short humerus (HP:0005792)2.52257462
76Rectal fistula (HP:0100590)2.52125947
77Rectovaginal fistula (HP:0000143)2.52125947
78Hypochromic microcytic anemia (HP:0004840)2.50804608
79Hemoptysis (HP:0002105)2.50615407
80Premature ovarian failure (HP:0008209)2.49258191
81Duodenal stenosis (HP:0100867)2.48698300
82Small intestinal stenosis (HP:0012848)2.48698300
83Thyroiditis (HP:0100646)2.47912758
84Tracheoesophageal fistula (HP:0002575)2.46986981
85Attenuation of retinal blood vessels (HP:0007843)2.45693342
86IgG deficiency (HP:0004315)2.44797108
87Horseshoe kidney (HP:0000085)2.43634672
88Glioma (HP:0009733)2.43344172
89Eczematoid dermatitis (HP:0000976)2.42632802
90Ectopic kidney (HP:0000086)2.42522561
91Premature graying of hair (HP:0002216)2.42302131
92Trismus (HP:0000211)2.40117369
93Vasculitis (HP:0002633)2.37598030
94Bone marrow hypocellularity (HP:0005528)2.37408632
95Abnormality of B cell number (HP:0010975)2.35932804
96Myelodysplasia (HP:0002863)2.34536429
97Gingivitis (HP:0000230)2.32136248
98Abnormality of eosinophils (HP:0001879)2.31169741
99Nephronophthisis (HP:0000090)2.28432628
100Severe combined immunodeficiency (HP:0004430)2.28122905
101Neoplasm of the pancreas (HP:0002894)2.27635577
102Spinal muscular atrophy (HP:0007269)2.27621745
103Pulmonary infiltrates (HP:0002113)2.27479493
104Chest pain (HP:0100749)2.26202132
105Albinism (HP:0001022)2.26043956
106Abnormal trabecular bone morphology (HP:0100671)2.25619290
107True hermaphroditism (HP:0010459)2.25439337
108Triphalangeal thumb (HP:0001199)2.25290164
109Stenosis of the external auditory canal (HP:0000402)2.25285933
110Abnormality of the renal cortex (HP:0011035)2.24190624
111Meningitis (HP:0001287)2.23427055
112Abnormality of the duodenum (HP:0002246)2.22002346
113Cellular immunodeficiency (HP:0005374)2.21982482
114Neoplasm of striated muscle (HP:0009728)2.20422844
115Genetic anticipation (HP:0003743)2.20356708
116Fused cervical vertebrae (HP:0002949)2.20252880
117Increased IgM level (HP:0003496)2.18966654
118Eosinophilia (HP:0001880)2.18676739
119Intestinal fistula (HP:0100819)2.18225234
120Hyperventilation (HP:0002883)2.17214581
121Abnormality of the renal collecting system (HP:0004742)2.16473372
122Sloping forehead (HP:0000340)2.16077175
123Abnormality of the prostate (HP:0008775)2.15622863
124Abnormality of cells of the erythroid lineage (HP:0012130)2.15341504
125Autoimmune thrombocytopenia (HP:0001973)2.13775664
126Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12256364
127Abnormality of macrophages (HP:0004311)2.11772793
128Abnormality of the renal medulla (HP:0100957)2.11636299
129Abnormal lung lobation (HP:0002101)2.11212076
130Basal cell carcinoma (HP:0002671)2.10948125
131Missing ribs (HP:0000921)2.09206774
132Aplasia/Hypoplasia of the sternum (HP:0006714)2.08271398
133Short thumb (HP:0009778)2.06761861
134Gaze-evoked nystagmus (HP:0000640)2.06636152
135Medial flaring of the eyebrow (HP:0010747)2.05984008
136Multiple enchondromatosis (HP:0005701)2.05665234
137Breast aplasia (HP:0100783)2.05396801
138Shawl scrotum (HP:0000049)2.05061750
139Abnormality of pyrimidine metabolism (HP:0004353)2.03149058
140Amaurosis fugax (HP:0100576)2.01943486
141Constricted visual fields (HP:0001133)2.00004379
142Autoimmune hemolytic anemia (HP:0001890)1.99540157
143Pustule (HP:0200039)1.98044331
144Renal cortical cysts (HP:0000803)1.97429393
145Abnormal rod and cone electroretinograms (HP:0008323)1.96942595
146Urticaria (HP:0001025)1.96755190
147Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96694893
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96545196
149Anal stenosis (HP:0002025)1.96369172
150Progressive inability to walk (HP:0002505)1.95655111
151Anorexia (HP:0002039)1.95111764
152Granulocytopenia (HP:0001913)1.95040629
153Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94487612
154Vaginal fistula (HP:0004320)1.93946411
15511 pairs of ribs (HP:0000878)1.93505443
156Asplenia (HP:0001746)1.92943099
157Atresia of the external auditory canal (HP:0000413)1.92938784
158Episodic fever (HP:0001954)1.92880858
159Biliary tract neoplasm (HP:0100574)1.92078261
160Facial cleft (HP:0002006)1.91711562
161Cafe-au-lait spot (HP:0000957)1.89335078
162Aplasia/Hypoplasia of the breasts (HP:0010311)1.89052822
163Arterial thrombosis (HP:0004420)1.88755119
164Keratitis (HP:0000491)1.87892452
165Vertebral fusion (HP:0002948)1.86641575
166Abnormal number of erythroid precursors (HP:0012131)1.86356329
167Gangrene (HP:0100758)1.86283639
168Hypochromic anemia (HP:0001931)1.86106501
169Hemivertebrae (HP:0002937)1.84976518
170Absent speech (HP:0001344)1.84965195
171Abnormality of alanine metabolism (HP:0010916)1.84637544
172Hyperalaninemia (HP:0003348)1.84637544
173Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84637544
174B lymphocytopenia (HP:0010976)1.84232369
175Hematochezia (HP:0002573)1.84030532
176Deviation of the thumb (HP:0009603)1.83741163
177Nephroblastoma (Wilms tumor) (HP:0002667)1.83269521
178Dyskinesia (HP:0100660)1.82745177
179Aplasia/Hypoplasia of the spleen (HP:0010451)1.82738679
180Proximal placement of thumb (HP:0009623)1.82643718
181Esophageal atresia (HP:0002032)1.82351585
182Supernumerary bones of the axial skeleton (HP:0009144)1.82196973
183Aplastic anemia (HP:0001915)1.81674840
184Obstructive lung disease (HP:0006536)1.78236358
185Chronic obstructive pulmonary disease (HP:0006510)1.78236358
186Fair hair (HP:0002286)1.77863473
187Hypoproteinemia (HP:0003075)1.77728247
188Combined immunodeficiency (HP:0005387)1.75813492
189Abnormality of the pleura (HP:0002103)1.75047251
190Widely spaced teeth (HP:0000687)1.74886991
191Pulmonary embolism (HP:0002204)1.74481597
192Clumsiness (HP:0002312)1.73919957
193Decreased central vision (HP:0007663)1.72082004
194Prostate neoplasm (HP:0100787)1.71358731
195Chronic hepatic failure (HP:0100626)1.65693266
196Progressive cerebellar ataxia (HP:0002073)1.65621718
197Alveolar cell carcinoma (HP:0006519)1.64917006
198Cerebellar dysplasia (HP:0007033)1.64809347
199Parakeratosis (HP:0001036)1.64752077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.30723755
2BUB14.40435272
3WEE13.98070343
4CDC73.40046114
5EIF2AK13.06654643
6CDK123.03391671
7EPHA22.99505786
8NEK12.99305869
9BLK2.87944388
10TXK2.83804590
11TAOK32.79585869
12TTK2.72506187
13NEK22.55663948
14ADRBK22.52386233
15SRPK12.51805743
16PLK42.37826800
17MAP4K12.31141052
18PLK12.19908281
19TLK12.13547120
20TSSK62.12228436
21INSRR2.00157425
22FES1.93620647
23CDK71.90803907
24IRAK41.90143585
25TNK21.89182566
26WNK31.87792273
27ACVR1B1.82806052
28BMPR1B1.81756298
29RIPK41.80859560
30RPS6KB21.79009542
31MAP4K21.72549356
32NUAK11.67735957
33ATR1.64944202
34CHEK21.62408907
35IKBKE1.62053288
36PLK31.56465908
37AURKB1.56327935
38VRK11.54597700
39PBK1.52891997
40CSK1.50970841
41TESK21.50697527
42KIT1.50454356
43IRAK11.49709898
44NME21.48133298
45TEC1.47769936
46PINK11.47578339
47DYRK31.47107034
48PASK1.45231351
49EIF2AK31.44094721
50STK41.43782131
51MAP3K81.42726611
52ZAK1.41640753
53SYK1.38337715
54CHEK11.37051483
55STK101.35384547
56AURKA1.34971929
57GRK11.34479499
58CSF1R1.32739428
59PIM11.28280777
60CDK41.27229509
61STK38L1.26914353
62TRIM281.26262199
63LYN1.25580317
64TYK21.23353122
65MAP3K131.20786345
66SIK31.19653800
67MAPKAPK31.18547321
68HCK1.18338656
69PIK3CG1.18198978
70BTK1.17358735
71MAPK131.17240173
72PTK2B1.12192757
73FGR1.11314423
74MAP3K101.11133048
75BRD41.10824456
76LCK1.09766311
77MARK31.09147900
78LATS21.05688336
79OXSR11.04480087
80MKNK11.03147349
81BRSK21.02351240
82ALK1.01619840
83PAK41.01339555
84CDK191.01086824
85ITK0.98731200
86ATM0.97925757
87MAP3K40.97325527
88CDK20.96701952
89AKT30.95441155
90ZAP700.92761462
91JAK30.92285855
92SCYL20.91853209
93EIF2AK20.90727109
94MKNK20.88359878
95MAP2K30.87325821
96RPS6KA40.87122931
97PNCK0.86878837
98ERBB30.86791895
99PRKCI0.85752910
100TESK10.85666479
101PIM20.83035775
102MELK0.81225954
103MATK0.80289619
104JAK20.76772363
105CAMKK20.76615039
106NTRK30.76593043
107MST40.76511109
108MAP3K110.75354092
109STK160.72912156
110BRAF0.72582335
111PRKCQ0.71919079
112STK30.71417675
113IRAK20.70374380
114MAP3K20.68264651
115CSNK2A20.68204135
116OBSCN0.68183216
117PAK10.67325586
118CDK10.66559216
119NLK0.65279920
120BRSK10.64378875
121CSNK2A10.63970756
122MAP3K70.62591441
123GRK70.62441652
124DYRK20.61518850
125CDK60.61374328
126PAK30.60985786
127ADRBK10.60724404
128BMPR20.59163126
129SGK20.58298418
130IKBKB0.57104569
131YES10.54718934
132TAOK20.54008636
133FLT30.53450147
134JAK10.50434177
135PDK20.49666000
136MTOR0.48639476
137EPHA30.48412280
138RPS6KA50.47879367
139TGFBR10.47188419
140EEF2K0.46992723
141BCR0.46561928
142STK110.45847729
143TBK10.45167197
144IGF1R0.45151681
145CSNK1G10.44588538
146AKT20.44221477
147LATS10.43722736
148CHUK0.43496762
149TGFBR20.42878817
150PRKAA20.42503194
151MET0.41994252
152CSNK1E0.41981032
153ABL10.41618100
154PLK20.40802140
155GRK60.40765428
156CSNK1G20.40705028
157CSNK1G30.40456783
158PDK10.39800574
159EGFR0.39409861
160CSNK1D0.38062756
161CSNK1A1L0.37380321
162MAP2K40.36836688
163PRKCE0.36762710
164DAPK20.36341083
165MAP3K140.36237610
166PRKDC0.35183612
167WNK10.33524141
168SIK20.32534206
169DYRK1A0.30831702
170KSR10.30714653
171AKT10.29686273
172IRAK30.29619143
173CAMK40.29324388
174CLK10.28001406
175MAP3K30.27948406
176BMX0.27100473
177MAPK140.26784738
178NEK60.25467125
179FGFR10.23316088
180MAPK10.21790544
181ARAF0.21340836
182GSK3B0.21264811
183ICK0.20323278

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.45129987
2Mismatch repair_Homo sapiens_hsa034304.20699904
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.04244110
4RNA polymerase_Homo sapiens_hsa030203.39939301
5RNA transport_Homo sapiens_hsa030133.19306079
6Proteasome_Homo sapiens_hsa030503.12690624
7Spliceosome_Homo sapiens_hsa030403.11775509
8One carbon pool by folate_Homo sapiens_hsa006703.10667451
9Homologous recombination_Homo sapiens_hsa034403.00213708
10Base excision repair_Homo sapiens_hsa034102.88112756
11Staphylococcus aureus infection_Homo sapiens_hsa051502.81351866
12Ribosome_Homo sapiens_hsa030102.80701399
13Nucleotide excision repair_Homo sapiens_hsa034202.74372913
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.57660006
15Cell cycle_Homo sapiens_hsa041102.55506961
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.47777403
17Fanconi anemia pathway_Homo sapiens_hsa034602.45091097
18Pyrimidine metabolism_Homo sapiens_hsa002402.31479037
19Non-homologous end-joining_Homo sapiens_hsa034502.17155880
20Osteoclast differentiation_Homo sapiens_hsa043802.05261396
21Basal transcription factors_Homo sapiens_hsa030221.93751534
22Regulation of autophagy_Homo sapiens_hsa041401.88675252
23Tuberculosis_Homo sapiens_hsa051521.84990966
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83828096
25p53 signaling pathway_Homo sapiens_hsa041151.83455886
26RNA degradation_Homo sapiens_hsa030181.82715453
27mRNA surveillance pathway_Homo sapiens_hsa030151.75609802
28Phototransduction_Homo sapiens_hsa047441.71533223
29Rheumatoid arthritis_Homo sapiens_hsa053231.61054670
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59934914
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58707468
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36141163
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34282338
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33286575
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31136791
36Epstein-Barr virus infection_Homo sapiens_hsa051691.25143604
37Malaria_Homo sapiens_hsa051441.24484957
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.23520822
39T cell receptor signaling pathway_Homo sapiens_hsa046601.20751057
40Systemic lupus erythematosus_Homo sapiens_hsa053221.20555131
41Linoleic acid metabolism_Homo sapiens_hsa005911.18801263
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17058015
43Purine metabolism_Homo sapiens_hsa002301.16521938
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14430142
45Taste transduction_Homo sapiens_hsa047421.13133246
46B cell receptor signaling pathway_Homo sapiens_hsa046621.12171380
47Ether lipid metabolism_Homo sapiens_hsa005651.10074239
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07009332
49Herpes simplex infection_Homo sapiens_hsa051681.04703650
50Chemokine signaling pathway_Homo sapiens_hsa040621.03843374
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03599146
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03312369
53Dorso-ventral axis formation_Homo sapiens_hsa043200.99429247
54African trypanosomiasis_Homo sapiens_hsa051430.97261601
55Viral carcinogenesis_Homo sapiens_hsa052030.96320457
56Folate biosynthesis_Homo sapiens_hsa007900.95778672
57Phagosome_Homo sapiens_hsa041450.95118009
58Toxoplasmosis_Homo sapiens_hsa051450.94101898
59Biosynthesis of amino acids_Homo sapiens_hsa012300.91308545
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89168939
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89013044
62Nitrogen metabolism_Homo sapiens_hsa009100.87853291
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.87257012
64Pertussis_Homo sapiens_hsa051330.85168741
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84524173
66Olfactory transduction_Homo sapiens_hsa047400.84472153
67TNF signaling pathway_Homo sapiens_hsa046680.83397549
68Oocyte meiosis_Homo sapiens_hsa041140.82502430
69Legionellosis_Homo sapiens_hsa051340.81050562
70Selenocompound metabolism_Homo sapiens_hsa004500.80588431
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76758327
72Vitamin B6 metabolism_Homo sapiens_hsa007500.76229631
73Graft-versus-host disease_Homo sapiens_hsa053320.74856312
74Antigen processing and presentation_Homo sapiens_hsa046120.72412204
75Hippo signaling pathway_Homo sapiens_hsa043900.72320207
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.71310725
77Caffeine metabolism_Homo sapiens_hsa002320.70509897
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68528770
79Morphine addiction_Homo sapiens_hsa050320.67559646
80MicroRNAs in cancer_Homo sapiens_hsa052060.67432015
81HTLV-I infection_Homo sapiens_hsa051660.67069678
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65654408
83Allograft rejection_Homo sapiens_hsa053300.63936727
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63566359
85Glycerolipid metabolism_Homo sapiens_hsa005610.63494199
86Basal cell carcinoma_Homo sapiens_hsa052170.62698553
87Pentose phosphate pathway_Homo sapiens_hsa000300.62645961
88Butanoate metabolism_Homo sapiens_hsa006500.62026996
89Lysosome_Homo sapiens_hsa041420.61751920
90Circadian rhythm_Homo sapiens_hsa047100.61725224
91TGF-beta signaling pathway_Homo sapiens_hsa043500.61162371
92ABC transporters_Homo sapiens_hsa020100.61136729
93Platelet activation_Homo sapiens_hsa046110.60768965
94Collecting duct acid secretion_Homo sapiens_hsa049660.60306591
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.59948450
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59736137
97Fructose and mannose metabolism_Homo sapiens_hsa000510.59407114
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59137820
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59111896
100Apoptosis_Homo sapiens_hsa042100.55753299
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.54361070
102Tryptophan metabolism_Homo sapiens_hsa003800.52712616
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50770013
104Serotonergic synapse_Homo sapiens_hsa047260.50569763
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49824739
106Small cell lung cancer_Homo sapiens_hsa052220.49515191
107Peroxisome_Homo sapiens_hsa041460.49343610
108Glutathione metabolism_Homo sapiens_hsa004800.49315044
109Influenza A_Homo sapiens_hsa051640.47599541
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.46765335
111Measles_Homo sapiens_hsa051620.46464641
112Notch signaling pathway_Homo sapiens_hsa043300.46025818
113Thyroid cancer_Homo sapiens_hsa052160.45988515
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44840031
115FoxO signaling pathway_Homo sapiens_hsa040680.44636193
116Hedgehog signaling pathway_Homo sapiens_hsa043400.44313786
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43558670
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42056879
119Ovarian steroidogenesis_Homo sapiens_hsa049130.41375913
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40840095
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40682207
122Huntingtons disease_Homo sapiens_hsa050160.37924498
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.37360158
124HIF-1 signaling pathway_Homo sapiens_hsa040660.36481585
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35025793
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34961766
127Bladder cancer_Homo sapiens_hsa052190.34482536
128Sulfur relay system_Homo sapiens_hsa041220.34129516
129Adherens junction_Homo sapiens_hsa045200.33736566
130Type I diabetes mellitus_Homo sapiens_hsa049400.32892904
131Protein export_Homo sapiens_hsa030600.32824523
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.32543690
133Carbon metabolism_Homo sapiens_hsa012000.31946928
134Colorectal cancer_Homo sapiens_hsa052100.31386117
135Shigellosis_Homo sapiens_hsa051310.31381543
136Pathways in cancer_Homo sapiens_hsa052000.27850516
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26588743
138Autoimmune thyroid disease_Homo sapiens_hsa053200.26101852
139Primary immunodeficiency_Homo sapiens_hsa053400.26085039
140Hepatitis B_Homo sapiens_hsa051610.25524325
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24593675
142Alcoholism_Homo sapiens_hsa050340.24571761
143Galactose metabolism_Homo sapiens_hsa000520.23348718
144Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23232810
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22479327
146Hepatitis C_Homo sapiens_hsa051600.22472093
147Calcium signaling pathway_Homo sapiens_hsa040200.21530421
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.21447226
149Tight junction_Homo sapiens_hsa045300.20980536
150Arginine and proline metabolism_Homo sapiens_hsa003300.20773094
151Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20688090
152Long-term depression_Homo sapiens_hsa047300.20579124
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.19670142
154Viral myocarditis_Homo sapiens_hsa054160.19539615
155mTOR signaling pathway_Homo sapiens_hsa041500.19467369
156Sphingolipid metabolism_Homo sapiens_hsa006000.19368445
157Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19180056
158Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18864342
159Hematopoietic cell lineage_Homo sapiens_hsa046400.17754641
160Asthma_Homo sapiens_hsa053100.17202713
161Arachidonic acid metabolism_Homo sapiens_hsa005900.16708696
162Melanoma_Homo sapiens_hsa052180.16228948
163Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14850888
164Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14300332
165Leishmaniasis_Homo sapiens_hsa051400.12115542
166Metabolic pathways_Homo sapiens_hsa011000.12032920

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