

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.90006094 |
| 2 | axonemal dynein complex assembly (GO:0070286) | 5.61953728 |
| 3 | ribosomal small subunit assembly (GO:0000028) | 4.89951499 |
| 4 | proteasome assembly (GO:0043248) | 4.76873522 |
| 5 | motile cilium assembly (GO:0044458) | 4.69978296 |
| 6 | viral transcription (GO:0019083) | 4.59937477 |
| 7 | maturation of SSU-rRNA (GO:0030490) | 4.58207042 |
| 8 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.57787523 |
| 9 | formation of translation preinitiation complex (GO:0001731) | 4.55548229 |
| 10 | translational termination (GO:0006415) | 4.50922692 |
| 11 | ribosomal small subunit biogenesis (GO:0042274) | 4.46659493 |
| 12 | nucleobase biosynthetic process (GO:0046112) | 4.34628034 |
| 13 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.34067792 |
| 14 | translational elongation (GO:0006414) | 4.30567446 |
| 15 | protein maturation by protein folding (GO:0022417) | 4.29145007 |
| 16 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.28481403 |
| 17 | purine nucleobase biosynthetic process (GO:0009113) | 4.20578643 |
| 18 | GTP biosynthetic process (GO:0006183) | 4.19492809 |
| 19 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 4.16928490 |
| 20 | ribosome biogenesis (GO:0042254) | 4.15955089 |
| 21 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.12824226 |
| 22 | termination of RNA polymerase III transcription (GO:0006386) | 4.12824226 |
| 23 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.12232877 |
| 24 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.11907111 |
| 25 | DNA strand elongation (GO:0022616) | 4.10737924 |
| 26 | translational initiation (GO:0006413) | 4.08942024 |
| 27 | peptidyl-arginine N-methylation (GO:0035246) | 4.07409636 |
| 28 | peptidyl-arginine methylation (GO:0018216) | 4.07409636 |
| 29 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 4.07239703 |
| 30 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.03862223 |
| 31 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.00785251 |
| 32 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 4.00347198 |
| 33 | regulation of mitochondrial translation (GO:0070129) | 3.99197955 |
| 34 | pseudouridine synthesis (GO:0001522) | 3.98778446 |
| 35 | ribosomal large subunit biogenesis (GO:0042273) | 3.96666971 |
| 36 | UTP metabolic process (GO:0046051) | 3.96483174 |
| 37 | DNA replication initiation (GO:0006270) | 3.95769014 |
| 38 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.94238552 |
| 39 | negative regulation of ligase activity (GO:0051352) | 3.93575494 |
| 40 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.93575494 |
| 41 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.93128695 |
| 42 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.92962471 |
| 43 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.91051276 |
| 44 | GDP-mannose metabolic process (GO:0019673) | 3.87413301 |
| 45 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.84154477 |
| 46 | left/right pattern formation (GO:0060972) | 3.82767793 |
| 47 | spliceosomal snRNP assembly (GO:0000387) | 3.82488781 |
| 48 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.80566151 |
| 49 | proline biosynthetic process (GO:0006561) | 3.77699830 |
| 50 | protein insertion into membrane (GO:0051205) | 3.77226767 |
| 51 | mitotic nuclear envelope reassembly (GO:0007084) | 3.75746087 |
| 52 | nuclear envelope reassembly (GO:0031468) | 3.75746087 |
| 53 | cotranslational protein targeting to membrane (GO:0006613) | 3.75745125 |
| 54 | CTP biosynthetic process (GO:0006241) | 3.75271266 |
| 55 | CTP metabolic process (GO:0046036) | 3.75271266 |
| 56 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.74755322 |
| 57 | cellular protein complex disassembly (GO:0043624) | 3.73152121 |
| 58 | protein targeting to ER (GO:0045047) | 3.72831161 |
| 59 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.72801368 |
| 60 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.71073510 |
| 61 | rRNA processing (GO:0006364) | 3.69785515 |
| 62 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.65821914 |
| 63 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.65678037 |
| 64 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.65678037 |
| 65 | rRNA modification (GO:0000154) | 3.64195056 |
| 66 | viral life cycle (GO:0019058) | 3.64175429 |
| 67 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 3.62971697 |
| 68 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.61340555 |
| 69 | translation (GO:0006412) | 3.59642370 |
| 70 | ATP synthesis coupled proton transport (GO:0015986) | 3.59573685 |
| 71 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.59573685 |
| 72 | protein localization to endoplasmic reticulum (GO:0070972) | 3.59358650 |
| 73 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.58445366 |
| 74 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.58131608 |
| 75 | rRNA metabolic process (GO:0016072) | 3.55454806 |
| 76 | cellular component biogenesis (GO:0044085) | 3.55304760 |
| 77 | pentose metabolic process (GO:0019321) | 3.55143354 |
| 78 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.55012043 |
| 79 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.52752153 |
| 80 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.51818182 |
| 81 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.51818182 |
| 82 | establishment of protein localization to mitochondrion (GO:0072655) | 3.50587866 |
| 83 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.49999978 |
| 84 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.49999978 |
| 85 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.49999978 |
| 86 | protein targeting to mitochondrion (GO:0006626) | 3.48289143 |
| 87 | DNA replication checkpoint (GO:0000076) | 3.46800045 |
| 88 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.45401102 |
| 89 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.45401102 |
| 90 | pentose-phosphate shunt (GO:0006098) | 3.44606244 |
| 91 | chaperone-mediated protein transport (GO:0072321) | 3.44590241 |
| 92 | cullin deneddylation (GO:0010388) | 3.41548166 |
| 93 | positive regulation of ligase activity (GO:0051351) | 3.41097103 |
| 94 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.40001850 |
| 95 | maturation of 5.8S rRNA (GO:0000460) | 3.38961551 |
| 96 | protein complex disassembly (GO:0043241) | 3.37707345 |
| 97 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 3.37071149 |
| 98 | protein deneddylation (GO:0000338) | 3.35004216 |
| 99 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.33307546 |
| 100 | telomere maintenance via recombination (GO:0000722) | 3.32705490 |
| 101 | iron-sulfur cluster assembly (GO:0016226) | 3.32479791 |
| 102 | metallo-sulfur cluster assembly (GO:0031163) | 3.32479791 |
| 103 | protein retention in ER lumen (GO:0006621) | 3.30189898 |
| 104 | macromolecular complex disassembly (GO:0032984) | 3.29298385 |
| 105 | base-excision repair, AP site formation (GO:0006285) | 3.27278829 |
| 106 | DNA unwinding involved in DNA replication (GO:0006268) | 3.25155414 |
| 107 | folic acid metabolic process (GO:0046655) | 3.24587747 |
| 108 | 7-methylguanosine mRNA capping (GO:0006370) | 3.24155830 |
| 109 | ribosome assembly (GO:0042255) | 3.24075516 |
| 110 | oxidative phosphorylation (GO:0006119) | 3.21675216 |
| 111 | histone arginine methylation (GO:0034969) | 3.20970603 |
| 112 | protein localization to mitochondrion (GO:0070585) | 3.20602902 |
| 113 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.20483743 |
| 114 | amyloid precursor protein catabolic process (GO:0042987) | 3.20372965 |
| 115 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.19391977 |
| 116 | regulation of translational termination (GO:0006449) | 3.15280231 |
| 117 | RNA capping (GO:0036260) | 3.15125341 |
| 118 | 7-methylguanosine RNA capping (GO:0009452) | 3.15125341 |
| 119 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.13158951 |
| 120 | glucose catabolic process (GO:0006007) | 3.12871186 |
| 121 | L-methionine salvage (GO:0071267) | 3.11424443 |
| 122 | L-methionine biosynthetic process (GO:0071265) | 3.11424443 |
| 123 | amino acid salvage (GO:0043102) | 3.11424443 |
| 124 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.09498878 |
| 125 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.09498878 |
| 126 | regulation of ligase activity (GO:0051340) | 3.09257598 |
| 127 | UTP biosynthetic process (GO:0006228) | 3.07222860 |
| 128 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.07103859 |
| 129 | telomere maintenance via telomere lengthening (GO:0010833) | 3.05364895 |
| 130 | rRNA transcription (GO:0009303) | 3.03213638 |
| 131 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.02871855 |
| 132 | cell cycle G1/S phase transition (GO:0044843) | 3.02871855 |
| 133 | NADPH regeneration (GO:0006740) | 3.01515903 |
| 134 | GMP metabolic process (GO:0046037) | 3.01071565 |
| 135 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling | 2.99068373 |
| 136 | pyrimidine nucleotide biosynthetic process (GO:0006221) | 2.96172195 |
| 137 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.95341124 |
| 138 | cilium movement (GO:0003341) | 2.94556889 |
| 139 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.94436261 |
| 140 | cilium or flagellum-dependent cell motility (GO:0001539) | 2.94362370 |
| 141 | establishment of integrated proviral latency (GO:0075713) | 2.94070186 |
| 142 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.93987493 |
| 143 | deoxyribonucleotide catabolic process (GO:0009264) | 2.90810790 |
| 144 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.89668427 |
| 145 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.88088165 |
| 146 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.87643343 |
| 147 | COPI coating of Golgi vesicle (GO:0048205) | 2.85389465 |
| 148 | Golgi transport vesicle coating (GO:0048200) | 2.85389465 |
| 149 | ncRNA 3-end processing (GO:0043628) | 2.82480058 |
| 150 | protein complex biogenesis (GO:0070271) | 2.81962911 |
| 151 | respiratory electron transport chain (GO:0022904) | 2.81415058 |
| 152 | negative regulation of release of cytochrome c from mitochondria (GO:0090201) | 2.80720643 |
| 153 | base-excision repair (GO:0006284) | 2.78266410 |
| 154 | electron transport chain (GO:0022900) | 2.77918667 |
| 155 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.77102326 |
| 156 | establishment of viral latency (GO:0019043) | 2.76997103 |
| 157 | mitochondrial fusion (GO:0008053) | 2.74556393 |
| 158 | UV protection (GO:0009650) | 2.73401147 |
| 159 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.71495576 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.78428765 |
| 2 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.61057675 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.41111529 |
| 4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.73033610 |
| 5 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.60077823 |
| 6 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.45091135 |
| 7 | * TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.34220964 |
| 8 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.32434579 |
| 9 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.28728901 |
| 10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.28599721 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.25317223 |
| 12 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.19674524 |
| 13 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.00169419 |
| 14 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.85543356 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.82581839 |
| 16 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.66838045 |
| 17 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.65207297 |
| 18 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.43201680 |
| 19 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.33002912 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.32697001 |
| 21 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.23281887 |
| 22 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.22382078 |
| 23 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.19957289 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.18939163 |
| 25 | LXR_22292898_ChIP-Seq_THP-1_Human | 2.17944209 |
| 26 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.14357185 |
| 27 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.13108667 |
| 28 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.12974442 |
| 29 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.05032915 |
| 30 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.04918345 |
| 31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.03931913 |
| 32 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.03189169 |
| 33 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.91574260 |
| 34 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.89502749 |
| 35 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.79999827 |
| 36 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.79572281 |
| 37 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.76517187 |
| 38 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.76329530 |
| 39 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.75838207 |
| 40 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.74163438 |
| 41 | P68_20966046_ChIP-Seq_HELA_Human | 1.73957973 |
| 42 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.67462842 |
| 43 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.67065246 |
| 44 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.66960592 |
| 45 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.63638361 |
| 46 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.63512855 |
| 47 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.61123896 |
| 48 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.60147626 |
| 49 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.59924358 |
| 50 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.59143589 |
| 51 | MYC_22102868_ChIP-Seq_BL_Human | 1.57691535 |
| 52 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.57614055 |
| 53 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.56367271 |
| 54 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.56182844 |
| 55 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.55214520 |
| 56 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.53890306 |
| 57 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.51429489 |
| 58 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.50346327 |
| 59 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.45514963 |
| 60 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.43831267 |
| 61 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.40733543 |
| 62 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.39847597 |
| 63 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.39022722 |
| 64 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.37763861 |
| 65 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.36466495 |
| 66 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.35836844 |
| 67 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35070745 |
| 68 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.34412458 |
| 69 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.32078038 |
| 70 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.31542224 |
| 71 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.29883938 |
| 72 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.29392157 |
| 73 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.29000644 |
| 74 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.28430012 |
| 75 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.25988271 |
| 76 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.24374548 |
| 77 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.24101562 |
| 78 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.22989634 |
| 79 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.22794104 |
| 80 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.21816370 |
| 81 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.21258279 |
| 82 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.20639190 |
| 83 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.20204839 |
| 84 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.19844782 |
| 85 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.19495334 |
| 86 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.19098264 |
| 87 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 1.19032819 |
| 88 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.18720298 |
| 89 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.18013947 |
| 90 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.17669812 |
| 91 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.16175248 |
| 92 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.15738377 |
| 93 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.15711573 |
| 94 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.15455681 |
| 95 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.15122026 |
| 96 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.12578662 |
| 97 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.12511965 |
| 98 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.12096948 |
| 99 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.10368274 |
| 100 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.10031320 |
| 101 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.09466610 |
| 102 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.09011950 |
| 103 | * YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.07930232 |
| 104 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 1.07823053 |
| 105 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.07431798 |
| 106 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.07141831 |
| 107 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.06596617 |
| 108 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.05443959 |
| 109 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.05046386 |
| 110 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.04678447 |
| 111 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.03883857 |
| 112 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.03838381 |
| 113 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.03606287 |
| 114 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.03589278 |
| 115 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.03450658 |
| 116 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.03305922 |
| 117 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.01184326 |
| 118 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.00810272 |
| 119 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.00500790 |
| 120 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.00220824 |
| 121 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.98437100 |
| 122 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.98331345 |
| 123 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.97852857 |
| 124 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.93879165 |
| 125 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93558352 |
| 126 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.93066989 |
| 127 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.93034768 |
| 128 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.90525980 |
| 129 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.90376533 |
| 130 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.89606449 |
| 131 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.88679185 |
| 132 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.87257941 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.98681215 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 3.93552900 |
| 3 | MP0010030_abnormal_orbit_morphology | 3.76018830 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.67818839 |
| 5 | MP0000678_abnormal_parathyroid_gland | 3.38864468 |
| 6 | MP0010094_abnormal_chromosome_stability | 3.13008462 |
| 7 | MP0003077_abnormal_cell_cycle | 2.96422171 |
| 8 | MP0002249_abnormal_larynx_morphology | 2.90563561 |
| 9 | MP0002396_abnormal_hematopoietic_system | 2.60005437 |
| 10 | MP0002234_abnormal_pharynx_morphology | 2.58781377 |
| 11 | MP0008058_abnormal_DNA_repair | 2.58446524 |
| 12 | MP0008932_abnormal_embryonic_tissue | 2.40685427 |
| 13 | MP0004859_abnormal_synaptic_plasticity | 2.38198604 |
| 14 | MP0008057_abnormal_DNA_replication | 2.33605595 |
| 15 | MP0001529_abnormal_vocalization | 2.33335154 |
| 16 | MP0003123_paternal_imprinting | 2.28662649 |
| 17 | MP0005623_abnormal_meninges_morphology | 2.27815030 |
| 18 | MP0006036_abnormal_mitochondrial_physio | 2.12787461 |
| 19 | MP0000049_abnormal_middle_ear | 2.01443034 |
| 20 | MP0006035_abnormal_mitochondrial_morpho | 1.95354156 |
| 21 | MP0005499_abnormal_olfactory_system | 1.94696971 |
| 22 | MP0005394_taste/olfaction_phenotype | 1.94696971 |
| 23 | MP0008789_abnormal_olfactory_epithelium | 1.93991806 |
| 24 | MP0002132_abnormal_respiratory_system | 1.90691881 |
| 25 | MP0005451_abnormal_body_composition | 1.87919323 |
| 26 | MP0000681_abnormal_thyroid_gland | 1.86761224 |
| 27 | MP0001968_abnormal_touch/_nociception | 1.85016893 |
| 28 | MP0003786_premature_aging | 1.82752027 |
| 29 | MP0005501_abnormal_skin_physiology | 1.82204156 |
| 30 | MP0000537_abnormal_urethra_morphology | 1.81387890 |
| 31 | MP0001730_embryonic_growth_arrest | 1.81370252 |
| 32 | MP0000358_abnormal_cell_content/ | 1.80535278 |
| 33 | MP0003880_abnormal_central_pattern | 1.74593588 |
| 34 | MP0008007_abnormal_cellular_replicative | 1.72373726 |
| 35 | MP0001346_abnormal_lacrimal_gland | 1.70046427 |
| 36 | MP0002877_abnormal_melanocyte_morpholog | 1.68151245 |
| 37 | MP0001905_abnormal_dopamine_level | 1.66409649 |
| 38 | MP0002822_catalepsy | 1.64329585 |
| 39 | MP0005423_abnormal_somatic_nervous | 1.62654048 |
| 40 | MP0006292_abnormal_olfactory_placode | 1.62350988 |
| 41 | MP0003718_maternal_effect | 1.53995052 |
| 42 | MP0000566_synostosis | 1.53323251 |
| 43 | MP0002736_abnormal_nociception_after | 1.53133381 |
| 44 | MP0001188_hyperpigmentation | 1.53013547 |
| 45 | MP0002733_abnormal_thermal_nociception | 1.51692504 |
| 46 | MP0006276_abnormal_autonomic_nervous | 1.49928408 |
| 47 | MP0009333_abnormal_splenocyte_physiolog | 1.49723480 |
| 48 | MP0000350_abnormal_cell_proliferation | 1.47794243 |
| 49 | MP0001545_abnormal_hematopoietic_system | 1.47664035 |
| 50 | MP0005397_hematopoietic_system_phenotyp | 1.47664035 |
| 51 | MP0003635_abnormal_synaptic_transmissio | 1.47132926 |
| 52 | MP0001849_ear_inflammation | 1.46989627 |
| 53 | MP0008877_abnormal_DNA_methylation | 1.45001687 |
| 54 | MP0002796_impaired_skin_barrier | 1.41299168 |
| 55 | MP0000490_abnormal_crypts_of | 1.39076602 |
| 56 | MP0001986_abnormal_taste_sensitivity | 1.39065691 |
| 57 | MP0000313_abnormal_cell_death | 1.37575240 |
| 58 | MP0002653_abnormal_ependyma_morphology | 1.37363438 |
| 59 | MP0008875_abnormal_xenobiotic_pharmacok | 1.36367460 |
| 60 | MP0004185_abnormal_adipocyte_glucose | 1.34584343 |
| 61 | MP0002080_prenatal_lethality | 1.34307646 |
| 62 | MP0000751_myopathy | 1.32965564 |
| 63 | MP0003656_abnormal_erythrocyte_physiolo | 1.32407723 |
| 64 | MP0004147_increased_porphyrin_level | 1.31725782 |
| 65 | MP0009379_abnormal_foot_pigmentation | 1.30766589 |
| 66 | MP0001697_abnormal_embryo_size | 1.30492108 |
| 67 | MP0004142_abnormal_muscle_tone | 1.28170758 |
| 68 | MP0005075_abnormal_melanosome_morpholog | 1.27212414 |
| 69 | MP0005330_cardiomyopathy | 1.25163550 |
| 70 | MP0004811_abnormal_neuron_physiology | 1.24525806 |
| 71 | MP0002735_abnormal_chemical_nociception | 1.22877525 |
| 72 | MP0001970_abnormal_pain_threshold | 1.22734626 |
| 73 | MP0002160_abnormal_reproductive_system | 1.22380362 |
| 74 | MP0003763_abnormal_thymus_physiology | 1.21995876 |
| 75 | MP0008872_abnormal_physiological_respon | 1.21714005 |
| 76 | MP0005058_abnormal_lysosome_morphology | 1.20652937 |
| 77 | MP0004233_abnormal_muscle_weight | 1.20031753 |
| 78 | MP0004270_analgesia | 1.16304888 |
| 79 | MP0000467_abnormal_esophagus_morphology | 1.15520767 |
| 80 | MP0003646_muscle_fatigue | 1.15139789 |
| 81 | MP0002751_abnormal_autonomic_nervous | 1.14326169 |
| 82 | MP0000762_abnormal_tongue_morphology | 1.12470109 |
| 83 | MP0004133_heterotaxia | 1.12363650 |
| 84 | MP0002063_abnormal_learning/memory/cond | 1.11513536 |
| 85 | MP0009745_abnormal_behavioral_response | 1.10612672 |
| 86 | MP0002064_seizures | 1.08556563 |
| 87 | MP0002019_abnormal_tumor_incidence | 1.07594424 |
| 88 | MP0003879_abnormal_hair_cell | 1.06915712 |
| 89 | MP0002734_abnormal_mechanical_nocicepti | 1.06322672 |
| 90 | MP0003329_amyloid_beta_deposits | 1.03835420 |
| 91 | MP0008260_abnormal_autophagy | 1.03391115 |
| 92 | MP0003186_abnormal_redox_activity | 1.02070797 |
| 93 | MP0004808_abnormal_hematopoietic_stem | 1.01972137 |
| 94 | MP0003806_abnormal_nucleotide_metabolis | 1.00202902 |
| 95 | MP0003122_maternal_imprinting | 0.99901634 |
| 96 | MP0003315_abnormal_perineum_morphology | 0.98973008 |
| 97 | MP0002272_abnormal_nervous_system | 0.98120912 |
| 98 | MP0001727_abnormal_embryo_implantation | 0.97307958 |
| 99 | MP0000749_muscle_degeneration | 0.97284799 |
| 100 | MP0003221_abnormal_cardiomyocyte_apopto | 0.95995301 |
| 101 | MP0001672_abnormal_embryogenesis/_devel | 0.93998673 |
| 102 | MP0005380_embryogenesis_phenotype | 0.93998673 |
| 103 | MP0000733_abnormal_muscle_development | 0.93756585 |
| 104 | MP0003866_abnormal_defecation | 0.92656652 |
| 105 | MP0002089_abnormal_postnatal_growth/wei | 0.92625695 |
| 106 | MP0000703_abnormal_thymus_morphology | 0.92537777 |
| 107 | MP0002398_abnormal_bone_marrow | 0.91831503 |
| 108 | MP0002722_abnormal_immune_system | 0.90955055 |
| 109 | MP0009278_abnormal_bone_marrow | 0.90625498 |
| 110 | MP0000747_muscle_weakness | 0.90445664 |
| 111 | MP0000462_abnormal_digestive_system | 0.89948106 |
| 112 | MP0005083_abnormal_biliary_tract | 0.88830223 |
| 113 | MP0000750_abnormal_muscle_regeneration | 0.88536501 |
| 114 | MP0010352_gastrointestinal_tract_polyps | 0.87467925 |
| 115 | MP0000689_abnormal_spleen_morphology | 0.86830389 |
| 116 | MP0009840_abnormal_foam_cell | 0.85205793 |
| 117 | MP0008770_decreased_survivor_rate | 0.84930626 |
| 118 | MP0000759_abnormal_skeletal_muscle | 0.84750851 |
| 119 | MP0003984_embryonic_growth_retardation | 0.84682164 |
| 120 | MP0009046_muscle_twitch | 0.83872704 |
| 121 | MP0005670_abnormal_white_adipose | 0.83656799 |
| 122 | MP0003705_abnormal_hypodermis_morpholog | 0.83555196 |
| 123 | MP0002184_abnormal_innervation | 0.82929729 |
| 124 | MP0003121_genomic_imprinting | 0.82622583 |
| 125 | MP0003942_abnormal_urinary_system | 0.81911445 |
| 126 | MP0002088_abnormal_embryonic_growth/wei | 0.81328109 |
| 127 | MP0003453_abnormal_keratinocyte_physiol | 0.81198389 |
| 128 | MP0003567_abnormal_fetal_cardiomyocyte | 0.81152991 |
| 129 | MP0002085_abnormal_embryonic_tissue | 0.81070053 |
| 130 | MP0002269_muscular_atrophy | 0.80326647 |
| 131 | MP0000003_abnormal_adipose_tissue | 0.79582285 |
| 132 | MP0001145_abnormal_male_reproductive | 0.78683451 |
| 133 | MP0001764_abnormal_homeostasis | 0.78663388 |
| 134 | MP0002572_abnormal_emotion/affect_behav | 0.78483004 |
| 135 | MP0002210_abnormal_sex_determination | 0.78338796 |
| 136 | MP0004924_abnormal_behavior | 0.77798975 |
| 137 | MP0005386_behavior/neurological_phenoty | 0.77798975 |
| 138 | MP0004858_abnormal_nervous_system | 0.76798964 |
| 139 | MP0001440_abnormal_grooming_behavior | 0.75552181 |
| 140 | MP0009053_abnormal_anal_canal | 0.75219715 |
| 141 | MP0002084_abnormal_developmental_patter | 0.73747143 |
| 142 | MP0005384_cellular_phenotype | 0.73695047 |
| 143 | MP0010771_integument_phenotype | 0.73515548 |
| 144 | MP0002429_abnormal_blood_cell | 0.73145139 |
| 145 | MP0010234_abnormal_vibrissa_follicle | 0.72811777 |
| 146 | MP0002177_abnormal_outer_ear | 0.70775181 |
| 147 | MP0000858_altered_metastatic_potential | 0.70275785 |
| 148 | MP0003861_abnormal_nervous_system | 0.68583114 |
| 149 | MP0009672_abnormal_birth_weight | 0.68226343 |
| 150 | MP0003075_altered_response_to | 0.66814070 |
| 151 | MP0002277_abnormal_respiratory_mucosa | 0.66439098 |
| 152 | MP0001270_distended_abdomen | 0.66154068 |
| 153 | MP0001661_extended_life_span | 0.64361691 |
| 154 | MP0003938_abnormal_ear_development | 0.62704673 |
| 155 | MP0005165_increased_susceptibility_to | 0.59921951 |
| 156 | MP0001881_abnormal_mammary_gland | 0.59807675 |
| 157 | MP0002098_abnormal_vibrissa_morphology | 0.57971835 |
| 158 | MP0000955_abnormal_spinal_cord | 0.57682357 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 6.36796975 |
| 2 | Abnormal respiratory motile cilium physiology (HP:0012261) | 5.41529305 |
| 3 | Abnormal respiratory epithelium morphology (HP:0012253) | 5.36980824 |
| 4 | Abnormal respiratory motile cilium morphology (HP:0005938) | 5.36980824 |
| 5 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.00638642 |
| 6 | Abnormal ciliary motility (HP:0012262) | 4.86816503 |
| 7 | Absent/shortened dynein arms (HP:0200106) | 4.85194949 |
| 8 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 4.85194949 |
| 9 | Abnormal number of erythroid precursors (HP:0012131) | 4.83887414 |
| 10 | Rhinitis (HP:0012384) | 4.53222140 |
| 11 | Cerebral hypomyelination (HP:0006808) | 4.50395558 |
| 12 | Chronic bronchitis (HP:0004469) | 4.22604400 |
| 13 | Hepatocellular necrosis (HP:0001404) | 4.13361410 |
| 14 | Nasal polyposis (HP:0100582) | 4.05570951 |
| 15 | Aplastic anemia (HP:0001915) | 4.01287773 |
| 16 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.00703384 |
| 17 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.00703384 |
| 18 | Mitochondrial inheritance (HP:0001427) | 3.70221341 |
| 19 | Acute necrotizing encephalopathy (HP:0006965) | 3.68122562 |
| 20 | Birth length less than 3rd percentile (HP:0003561) | 3.67650845 |
| 21 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.60152116 |
| 22 | Abnormality of the anterior horn cell (HP:0006802) | 3.51314449 |
| 23 | Degeneration of anterior horn cells (HP:0002398) | 3.51314449 |
| 24 | Hepatic necrosis (HP:0002605) | 3.42270492 |
| 25 | Increased CSF lactate (HP:0002490) | 3.42241804 |
| 26 | Broad distal phalanx of finger (HP:0009836) | 3.40496317 |
| 27 | Reticulocytopenia (HP:0001896) | 3.29876439 |
| 28 | Abnormality of the nasal mucosa (HP:0000433) | 3.24440310 |
| 29 | Delusions (HP:0000746) | 3.23295676 |
| 30 | Increased serum lactate (HP:0002151) | 3.23109056 |
| 31 | Macrocytic anemia (HP:0001972) | 3.19739496 |
| 32 | Oral leukoplakia (HP:0002745) | 3.16636656 |
| 33 | Emotional lability (HP:0000712) | 3.14155551 |
| 34 | Male infertility (HP:0003251) | 3.12368139 |
| 35 | Congenital malformation of the right heart (HP:0011723) | 3.09069026 |
| 36 | Double outlet right ventricle (HP:0001719) | 3.09069026 |
| 37 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 3.05079390 |
| 38 | Truncus arteriosus (HP:0001660) | 3.01513778 |
| 39 | CNS hypomyelination (HP:0003429) | 2.95613173 |
| 40 | Bronchiectasis (HP:0002110) | 2.92190908 |
| 41 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.90316485 |
| 42 | Microretrognathia (HP:0000308) | 2.85519993 |
| 43 | Carpal bone hypoplasia (HP:0001498) | 2.83772809 |
| 44 | Atelectasis (HP:0100750) | 2.82824068 |
| 45 | Pallor (HP:0000980) | 2.81393065 |
| 46 | Rough bone trabeculation (HP:0100670) | 2.80012019 |
| 47 | Acute encephalopathy (HP:0006846) | 2.79968246 |
| 48 | Lactic acidosis (HP:0003128) | 2.79739049 |
| 49 | Myokymia (HP:0002411) | 2.76319749 |
| 50 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.75768469 |
| 51 | Unsteady gait (HP:0002317) | 2.75020656 |
| 52 | Progressive macrocephaly (HP:0004481) | 2.73282016 |
| 53 | Breast hypoplasia (HP:0003187) | 2.73123843 |
| 54 | Increased hepatocellular lipid droplets (HP:0006565) | 2.69875008 |
| 55 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.69769690 |
| 56 | Poor suck (HP:0002033) | 2.63870786 |
| 57 | Progressive muscle weakness (HP:0003323) | 2.62922542 |
| 58 | Increased serum pyruvate (HP:0003542) | 2.58697954 |
| 59 | Abnormality of glycolysis (HP:0004366) | 2.58697954 |
| 60 | CNS demyelination (HP:0007305) | 2.55053958 |
| 61 | Increased intramyocellular lipid droplets (HP:0012240) | 2.53286686 |
| 62 | Upper limb amyotrophy (HP:0009129) | 2.52649987 |
| 63 | Distal upper limb amyotrophy (HP:0007149) | 2.52649987 |
| 64 | 3-Methylglutaconic aciduria (HP:0003535) | 2.52209895 |
| 65 | Stridor (HP:0010307) | 2.50466974 |
| 66 | Distal lower limb muscle weakness (HP:0009053) | 2.46032790 |
| 67 | Microvesicular hepatic steatosis (HP:0001414) | 2.45728909 |
| 68 | Colon cancer (HP:0003003) | 2.45390458 |
| 69 | Hand muscle atrophy (HP:0009130) | 2.44455238 |
| 70 | Respiratory failure (HP:0002878) | 2.42470733 |
| 71 | Exercise intolerance (HP:0003546) | 2.42294179 |
| 72 | Premature ovarian failure (HP:0008209) | 2.40067989 |
| 73 | Occipital encephalocele (HP:0002085) | 2.36551183 |
| 74 | Postnatal microcephaly (HP:0005484) | 2.35851171 |
| 75 | Myopathic facies (HP:0002058) | 2.34896661 |
| 76 | Hypoplastic left heart (HP:0004383) | 2.33370522 |
| 77 | Abnormal neuron morphology (HP:0012757) | 2.30918690 |
| 78 | Abnormality of the motor neurons (HP:0002450) | 2.30918690 |
| 79 | Pancytopenia (HP:0001876) | 2.30492223 |
| 80 | Hyperthyroidism (HP:0000836) | 2.30307812 |
| 81 | Hypokinesia (HP:0002375) | 2.29844151 |
| 82 | Absent thumb (HP:0009777) | 2.28201522 |
| 83 | Lipid accumulation in hepatocytes (HP:0006561) | 2.28141091 |
| 84 | Abnormal gallbladder physiology (HP:0012438) | 2.28014430 |
| 85 | Cholecystitis (HP:0001082) | 2.28014430 |
| 86 | Down-sloping shoulders (HP:0200021) | 2.24475370 |
| 87 | Abnormality of the umbilical cord (HP:0010881) | 2.22825090 |
| 88 | Visual hallucinations (HP:0002367) | 2.22194777 |
| 89 | Muscle fiber atrophy (HP:0100295) | 2.20789560 |
| 90 | Unilateral renal agenesis (HP:0000122) | 2.18571757 |
| 91 | Personality changes (HP:0000751) | 2.18429216 |
| 92 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.18424409 |
| 93 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.17489186 |
| 94 | Transposition of the great arteries (HP:0001669) | 2.16299092 |
| 95 | Abnormal connection of the cardiac segments (HP:0011545) | 2.16299092 |
| 96 | Abnormal ventriculo-arterial connection (HP:0011563) | 2.16299092 |
| 97 | Testicular atrophy (HP:0000029) | 2.15950356 |
| 98 | Hyperalaninemia (HP:0003348) | 2.15622636 |
| 99 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.15622636 |
| 100 | Abnormality of alanine metabolism (HP:0010916) | 2.15622636 |
| 101 | Multiple enchondromatosis (HP:0005701) | 2.12593468 |
| 102 | Amyotrophic lateral sclerosis (HP:0007354) | 2.10699447 |
| 103 | Infertility (HP:0000789) | 2.10625801 |
| 104 | Trismus (HP:0000211) | 2.10364750 |
| 105 | Self-mutilation (HP:0000742) | 2.09606261 |
| 106 | Secondary amenorrhea (HP:0000869) | 2.09488830 |
| 107 | Patellar aplasia (HP:0006443) | 2.09449155 |
| 108 | Short nail (HP:0001799) | 2.08907597 |
| 109 | Achilles tendon contracture (HP:0001771) | 2.08497820 |
| 110 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.07229930 |
| 111 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.07229930 |
| 112 | Single umbilical artery (HP:0001195) | 2.07229930 |
| 113 | Ragged-red muscle fibers (HP:0003200) | 2.05356032 |
| 114 | Type I transferrin isoform profile (HP:0003642) | 2.04536963 |
| 115 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.04412110 |
| 116 | Increased muscle lipid content (HP:0009058) | 2.03451150 |
| 117 | Respiratory difficulties (HP:0002880) | 2.02100714 |
| 118 | Megaloblastic anemia (HP:0001889) | 2.00977295 |
| 119 | Sclerocornea (HP:0000647) | 2.00314722 |
| 120 | Type 2 muscle fiber atrophy (HP:0003554) | 1.98879580 |
| 121 | Recurrent otitis media (HP:0000403) | 1.98201690 |
| 122 | Exertional dyspnea (HP:0002875) | 1.98099263 |
| 123 | Death in infancy (HP:0001522) | 1.94974072 |
| 124 | Abnormality of the labia minora (HP:0012880) | 1.94952722 |
| 125 | Angiofibromas (HP:0010615) | 1.93254311 |
| 126 | Adenoma sebaceum (HP:0009720) | 1.93254311 |
| 127 | Renal Fanconi syndrome (HP:0001994) | 1.92628578 |
| 128 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.90784385 |
| 129 | Limb dystonia (HP:0002451) | 1.90730276 |
| 130 | Diaphragmatic weakness (HP:0009113) | 1.90677813 |
| 131 | Horseshoe kidney (HP:0000085) | 1.90205785 |
| 132 | Neuroendocrine neoplasm (HP:0100634) | 1.89453133 |
| 133 | Hypoplasia of the pons (HP:0012110) | 1.87342423 |
| 134 | Tongue fasciculations (HP:0001308) | 1.87278483 |
| 135 | Hyperacusis (HP:0010780) | 1.86164951 |
| 136 | Hypertensive crisis (HP:0100735) | 1.84793124 |
| 137 | Leukodystrophy (HP:0002415) | 1.80979556 |
| 138 | Ependymoma (HP:0002888) | 1.80113758 |
| 139 | Abnormal trabecular bone morphology (HP:0100671) | 1.79605546 |
| 140 | Hypoplastic heart (HP:0001961) | 1.78727184 |
| 141 | Thrombocytosis (HP:0001894) | 1.76547640 |
| 142 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.76167924 |
| 143 | Selective tooth agenesis (HP:0001592) | 1.75983371 |
| 144 | Insomnia (HP:0100785) | 1.75237349 |
| 145 | Abnormality of the aortic arch (HP:0012303) | 1.74775923 |
| 146 | Premature graying of hair (HP:0002216) | 1.73584679 |
| 147 | Focal motor seizures (HP:0011153) | 1.73509311 |
| 148 | Cholelithiasis (HP:0001081) | 1.72077011 |
| 149 | Cerebral edema (HP:0002181) | 1.71290947 |
| 150 | Abnormality of pain sensation (HP:0010832) | 1.70526535 |
| 151 | Impaired pain sensation (HP:0007328) | 1.70526535 |
| 152 | Abnormality of the Achilles tendon (HP:0005109) | 1.70375716 |
| 153 | Abnormal number of incisors (HP:0011064) | 1.69549840 |
| 154 | Muscle fibrillation (HP:0010546) | 1.68451545 |
| 155 | Ankle clonus (HP:0011448) | 1.67981510 |
| 156 | Basal cell carcinoma (HP:0002671) | 1.67819749 |
| 157 | Spinal cord compression (HP:0002176) | 1.66284053 |
| 158 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.64258155 |
| 159 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 1.63260674 |
| 160 | Redundant skin (HP:0001582) | 1.61874989 |
| 161 | Abnormality of reticulocytes (HP:0004312) | 1.60832461 |
| 162 | Muscle stiffness (HP:0003552) | 1.60188753 |
| 163 | Abnormality of the tricuspid valve (HP:0001702) | 1.59666512 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.08325365 |
| 2 | BUB1 | 4.86050811 |
| 3 | SMG1 | 4.59658106 |
| 4 | WEE1 | 3.77499133 |
| 5 | STK16 | 3.52789944 |
| 6 | NME2 | 3.31255727 |
| 7 | TSSK6 | 2.81692418 |
| 8 | EIF2AK1 | 2.77416198 |
| 9 | TESK2 | 2.63833571 |
| 10 | TRIB3 | 2.49518185 |
| 11 | IRAK3 | 2.42319262 |
| 12 | CDK19 | 2.31024631 |
| 13 | PIM2 | 2.11987494 |
| 14 | CDC7 | 2.05999908 |
| 15 | ARAF | 2.05452512 |
| 16 | MAP3K12 | 1.96503504 |
| 17 | NEK1 | 1.92356879 |
| 18 | NME1 | 1.84863236 |
| 19 | MAPK15 | 1.83504870 |
| 20 | SCYL2 | 1.83315293 |
| 21 | MAP3K11 | 1.80936418 |
| 22 | BRSK1 | 1.72583348 |
| 23 | PRKD3 | 1.72110826 |
| 24 | DYRK3 | 1.67317162 |
| 25 | ICK | 1.65932163 |
| 26 | VRK1 | 1.65916495 |
| 27 | EIF2AK3 | 1.61992014 |
| 28 | CCNB1 | 1.60480101 |
| 29 | DAPK1 | 1.58926689 |
| 30 | BRAF | 1.48712415 |
| 31 | TAF1 | 1.46582543 |
| 32 | SRPK1 | 1.46404248 |
| 33 | ACVR1B | 1.45804974 |
| 34 | MINK1 | 1.41810170 |
| 35 | BRSK2 | 1.40864448 |
| 36 | NEK2 | 1.35353843 |
| 37 | TLK1 | 1.28048701 |
| 38 | AURKA | 1.24995324 |
| 39 | MAP3K9 | 1.21871914 |
| 40 | MARK1 | 1.15151190 |
| 41 | PLK4 | 1.12616266 |
| 42 | TESK1 | 1.11806656 |
| 43 | BCKDK | 1.10486172 |
| 44 | MAPKAPK5 | 1.06751571 |
| 45 | PLK1 | 1.05605827 |
| 46 | LMTK2 | 1.05235655 |
| 47 | CSNK1A1L | 1.04059541 |
| 48 | KDR | 1.01467298 |
| 49 | MAP4K1 | 0.99192210 |
| 50 | LIMK1 | 0.98601872 |
| 51 | PNCK | 0.98024186 |
| 52 | PASK | 0.97730930 |
| 53 | PAK4 | 0.93084294 |
| 54 | ILK | 0.91607936 |
| 55 | RPS6KB2 | 0.91104962 |
| 56 | DYRK2 | 0.88975070 |
| 57 | PRPF4B | 0.88333645 |
| 58 | MST1R | 0.86640840 |
| 59 | CSNK1G2 | 0.85357870 |
| 60 | ERN1 | 0.83604698 |
| 61 | PLK3 | 0.83139958 |
| 62 | MAP2K6 | 0.82504651 |
| 63 | SIK1 | 0.82389365 |
| 64 | LRRK2 | 0.81891974 |
| 65 | GRK6 | 0.78473542 |
| 66 | MAPKAPK3 | 0.78008604 |
| 67 | PRKCI | 0.77132303 |
| 68 | PAK1 | 0.75389037 |
| 69 | MAP2K3 | 0.75343282 |
| 70 | RAF1 | 0.75147092 |
| 71 | CDK7 | 0.74386433 |
| 72 | CDK8 | 0.73784135 |
| 73 | CAMK2G | 0.72850146 |
| 74 | DAPK3 | 0.72613966 |
| 75 | MAP2K2 | 0.72272083 |
| 76 | ATR | 0.71965821 |
| 77 | CAMKK2 | 0.70634604 |
| 78 | RPS6KA4 | 0.69379990 |
| 79 | ABL2 | 0.69178130 |
| 80 | CSNK1G1 | 0.68906438 |
| 81 | IRAK2 | 0.68443837 |
| 82 | AKT2 | 0.67843518 |
| 83 | TAOK1 | 0.67493662 |
| 84 | MATK | 0.64255775 |
| 85 | AURKB | 0.63777948 |
| 86 | CSNK2A2 | 0.63093056 |
| 87 | PBK | 0.62452996 |
| 88 | PDK3 | 0.62376414 |
| 89 | PDK4 | 0.62376414 |
| 90 | CDK9 | 0.62332381 |
| 91 | CDK18 | 0.60165695 |
| 92 | CDK14 | 0.60123391 |
| 93 | EPHA2 | 0.59788388 |
| 94 | MAP3K8 | 0.58850860 |
| 95 | CDK11A | 0.58396976 |
| 96 | CSNK1G3 | 0.58164820 |
| 97 | GRK5 | 0.57729612 |
| 98 | ZAP70 | 0.57685856 |
| 99 | CSNK2A1 | 0.56291993 |
| 100 | UHMK1 | 0.55982557 |
| 101 | TAOK2 | 0.55687637 |
| 102 | CDK15 | 0.55009611 |
| 103 | CHEK2 | 0.54218572 |
| 104 | STK10 | 0.53765470 |
| 105 | FLT3 | 0.53259273 |
| 106 | NTRK1 | 0.52782791 |
| 107 | EPHA4 | 0.52601137 |
| 108 | SIK3 | 0.52584274 |
| 109 | TTK | 0.52319381 |
| 110 | PAK6 | 0.51685670 |
| 111 | ALK | 0.47795140 |
| 112 | EPHB2 | 0.46633184 |
| 113 | CAMKK1 | 0.46148490 |
| 114 | NTRK3 | 0.45919742 |
| 115 | KSR1 | 0.45528615 |
| 116 | EEF2K | 0.43481870 |
| 117 | CAMK1 | 0.43428210 |
| 118 | TGFBR1 | 0.42833453 |
| 119 | LATS2 | 0.42271814 |
| 120 | PHKG1 | 0.41757184 |
| 121 | PHKG2 | 0.41757184 |
| 122 | PKN2 | 0.41513520 |
| 123 | CAMK2B | 0.40648463 |
| 124 | MAPK11 | 0.39861378 |
| 125 | PRKCG | 0.38917216 |
| 126 | MAP2K7 | 0.38838491 |
| 127 | MAP3K3 | 0.38554675 |
| 128 | CDK2 | 0.38218403 |
| 129 | SYK | 0.37589470 |
| 130 | CDK4 | 0.37497799 |
| 131 | ADRBK2 | 0.36836475 |
| 132 | KIT | 0.36729504 |
| 133 | CHEK1 | 0.36432077 |
| 134 | MAP3K10 | 0.35646221 |
| 135 | PTK2 | 0.34624737 |
| 136 | STK4 | 0.30896773 |
| 137 | TBK1 | 0.30773567 |
| 138 | RPS6KA5 | 0.30578426 |
| 139 | MAP3K1 | 0.29302655 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.73715384 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.58922535 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 4.46605309 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.93843745 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.33742041 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.15644190 |
| 7 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.92563219 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 2.88259442 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.66366307 |
| 10 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.61975266 |
| 11 | RNA transport_Homo sapiens_hsa03013 | 2.56256800 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 2.53627736 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.34460394 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.07320691 |
| 15 | Huntingtons disease_Homo sapiens_hsa05016 | 2.02140433 |
| 16 | Homologous recombination_Homo sapiens_hsa03440 | 1.90847364 |
| 17 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.75116990 |
| 18 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.73389419 |
| 19 | Purine metabolism_Homo sapiens_hsa00230 | 1.62956071 |
| 20 | Cell cycle_Homo sapiens_hsa04110 | 1.60179052 |
| 21 | Alzheimers disease_Homo sapiens_hsa05010 | 1.56575734 |
| 22 | Sulfur relay system_Homo sapiens_hsa04122 | 1.51425754 |
| 23 | RNA degradation_Homo sapiens_hsa03018 | 1.34555965 |
| 24 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.31629450 |
| 25 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.28595248 |
| 26 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.28419929 |
| 27 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.21445471 |
| 28 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.21362735 |
| 29 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.21186216 |
| 30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.20822622 |
| 31 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.17239056 |
| 32 | Basal transcription factors_Homo sapiens_hsa03022 | 1.16446144 |
| 33 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.14658772 |
| 34 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.14319204 |
| 35 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.14043034 |
| 36 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.12241205 |
| 37 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.09950649 |
| 38 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.09180554 |
| 39 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.08545294 |
| 40 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.07875054 |
| 41 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.06398226 |
| 42 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.06268241 |
| 43 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.05671948 |
| 44 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.96286931 |
| 45 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.93045379 |
| 46 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.88846973 |
| 47 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.88734448 |
| 48 | Protein export_Homo sapiens_hsa03060 | 0.86431362 |
| 49 | Carbon metabolism_Homo sapiens_hsa01200 | 0.82678274 |
| 50 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.78803116 |
| 51 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.78184129 |
| 52 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.77985738 |
| 53 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.77591901 |
| 54 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.75841849 |
| 55 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.73655909 |
| 56 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.71944888 |
| 57 | Thyroid cancer_Homo sapiens_hsa05216 | 0.71387838 |
| 58 | * Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.71195613 |
| 59 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.70061148 |
| 60 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.69845015 |
| 61 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.65686841 |
| 62 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.63830482 |
| 63 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.62537816 |
| 64 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.61959235 |
| 65 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.61836596 |
| 66 | Galactose metabolism_Homo sapiens_hsa00052 | 0.61023594 |
| 67 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.60586153 |
| 68 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.57547855 |
| 69 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.54696198 |
| 70 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.54006567 |
| 71 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.53522614 |
| 72 | Prion diseases_Homo sapiens_hsa05020 | 0.51567093 |
| 73 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.51479177 |
| 74 | Peroxisome_Homo sapiens_hsa04146 | 0.50709774 |
| 75 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.48144560 |
| 76 | Metabolic pathways_Homo sapiens_hsa01100 | 0.48123511 |
| 77 | Alcoholism_Homo sapiens_hsa05034 | 0.45124968 |
| 78 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.44358158 |
| 79 | Shigellosis_Homo sapiens_hsa05131 | 0.42213592 |
| 80 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.41784873 |
| 81 | Nicotine addiction_Homo sapiens_hsa05033 | 0.40435444 |
| 82 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.38833018 |
| 83 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.38800923 |
| 84 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.36243782 |
| 85 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.35649148 |
| 86 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.34889837 |
| 87 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.34328749 |
| 88 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.34318175 |
| 89 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.29416599 |
| 90 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.29056304 |
| 91 | Olfactory transduction_Homo sapiens_hsa04740 | 0.28619999 |
| 92 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.28449043 |
| 93 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.28345333 |
| 94 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.26683094 |
| 95 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.26136010 |
| 96 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.25492821 |
| 97 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.25355159 |
| 98 | Endocytosis_Homo sapiens_hsa04144 | 0.24611572 |
| 99 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.24408005 |
| 100 | Long-term potentiation_Homo sapiens_hsa04720 | 0.24228704 |
| 101 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.23835391 |
| 102 | HTLV-I infection_Homo sapiens_hsa05166 | 0.23126308 |
| 103 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.21865607 |
| 104 | Legionellosis_Homo sapiens_hsa05134 | 0.18948945 |
| 105 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.18616555 |
| 106 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.18453792 |
| 107 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.17672418 |
| 108 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.17630863 |
| 109 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.17421547 |
| 110 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.17090713 |
| 111 | Salmonella infection_Homo sapiens_hsa05132 | 0.16952597 |
| 112 | Colorectal cancer_Homo sapiens_hsa05210 | 0.16767204 |
| 113 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.14975823 |
| 114 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.12500711 |
| 115 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.11110695 |
| 116 | Bladder cancer_Homo sapiens_hsa05219 | 0.10910778 |
| 117 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.10843035 |
| 118 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.10408378 |
| 119 | Other glycan degradation_Homo sapiens_hsa00511 | 0.10375832 |
| 120 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.08730739 |
| 121 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.08288362 |
| 122 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.07353426 |
| 123 | Gap junction_Homo sapiens_hsa04540 | 0.07048528 |
| 124 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.06696569 |
| 125 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.06367220 |
| 126 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.05688191 |
| 127 | Apoptosis_Homo sapiens_hsa04210 | 0.04859230 |
| 128 | Cocaine addiction_Homo sapiens_hsa05030 | 0.02867522 |

