Rank | Gene Set | Z-score |
---|---|---|
1 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.22386025 |
2 | proteasome assembly (GO:0043248) | 5.09563083 |
3 | chaperone-mediated protein transport (GO:0072321) | 4.84799659 |
4 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.77228213 |
5 | ribosome assembly (GO:0042255) | 4.47947196 |
6 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.43911680 |
7 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.37644621 |
8 | negative regulation of ligase activity (GO:0051352) | 4.35583837 |
9 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.35583837 |
10 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.32450728 |
11 | rRNA modification (GO:0000154) | 4.31198287 |
12 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.26810198 |
13 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.20377709 |
14 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.19472394 |
15 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.19472394 |
16 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.19472394 |
17 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.17368336 |
18 | DNA deamination (GO:0045006) | 4.16994244 |
19 | maturation of 5.8S rRNA (GO:0000460) | 4.15068780 |
20 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.13503848 |
21 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.13503848 |
22 | cullin deneddylation (GO:0010388) | 4.07984883 |
23 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 4.07443819 |
24 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 4.07443819 |
25 | ATP synthesis coupled proton transport (GO:0015986) | 4.03109190 |
26 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.03109190 |
27 | maturation of SSU-rRNA (GO:0030490) | 4.02501475 |
28 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 4.00850856 |
29 | rRNA methylation (GO:0031167) | 3.93881820 |
30 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.92634906 |
31 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.87154429 |
32 | protein complex biogenesis (GO:0070271) | 3.86340033 |
33 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.84788505 |
34 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.84695274 |
35 | NADH dehydrogenase complex assembly (GO:0010257) | 3.84695274 |
36 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.84695274 |
37 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.81489490 |
38 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.81150938 |
39 | ribosomal large subunit biogenesis (GO:0042273) | 3.73502615 |
40 | protein deneddylation (GO:0000338) | 3.73308972 |
41 | rRNA processing (GO:0006364) | 3.69861040 |
42 | IMP biosynthetic process (GO:0006188) | 3.68184077 |
43 | termination of RNA polymerase I transcription (GO:0006363) | 3.67649151 |
44 | positive regulation of ligase activity (GO:0051351) | 3.65502305 |
45 | protein neddylation (GO:0045116) | 3.64141448 |
46 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.63944042 |
47 | termination of RNA polymerase III transcription (GO:0006386) | 3.63944042 |
48 | DNA double-strand break processing (GO:0000729) | 3.59539444 |
49 | pseudouridine synthesis (GO:0001522) | 3.57205324 |
50 | rRNA metabolic process (GO:0016072) | 3.56867523 |
51 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.55230743 |
52 | regulation of immunoglobulin secretion (GO:0051023) | 3.55128182 |
53 | spliceosomal snRNP assembly (GO:0000387) | 3.55089380 |
54 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.54807175 |
55 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.52471747 |
56 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.51510716 |
57 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.48596778 |
58 | isotype switching (GO:0045190) | 3.48596778 |
59 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.48596778 |
60 | chromatin remodeling at centromere (GO:0031055) | 3.46205170 |
61 | 7-methylguanosine mRNA capping (GO:0006370) | 3.46173453 |
62 | GTP biosynthetic process (GO:0006183) | 3.44497736 |
63 | DNA damage response, detection of DNA damage (GO:0042769) | 3.42008535 |
64 | CENP-A containing nucleosome assembly (GO:0034080) | 3.40470558 |
65 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.39635819 |
66 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.38635114 |
67 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.38036922 |
68 | 7-methylguanosine RNA capping (GO:0009452) | 3.37170847 |
69 | RNA capping (GO:0036260) | 3.37170847 |
70 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.34652652 |
71 | ribosome biogenesis (GO:0042254) | 3.32011640 |
72 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.31825998 |
73 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.31825998 |
74 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.28616034 |
75 | IMP metabolic process (GO:0046040) | 3.28456224 |
76 | DNA replication checkpoint (GO:0000076) | 3.27949689 |
77 | regulation of ligase activity (GO:0051340) | 3.27313185 |
78 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.24554529 |
79 | cellular component biogenesis (GO:0044085) | 3.24433450 |
80 | positive regulation of cell cycle arrest (GO:0071158) | 3.22942904 |
81 | translation (GO:0006412) | 3.21706378 |
82 | UTP biosynthetic process (GO:0006228) | 3.19230020 |
83 | formation of translation preinitiation complex (GO:0001731) | 3.16583600 |
84 | histone mRNA metabolic process (GO:0008334) | 3.16527022 |
85 | protein targeting to mitochondrion (GO:0006626) | 3.15965053 |
86 | mitochondrial RNA metabolic process (GO:0000959) | 3.14488663 |
87 | regulation of chronic inflammatory response (GO:0002676) | 3.13128630 |
88 | establishment of integrated proviral latency (GO:0075713) | 3.12751812 |
89 | nucleobase biosynthetic process (GO:0046112) | 3.12467620 |
90 | negative regulation of protein ubiquitination (GO:0031397) | 3.11067115 |
91 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.10444289 |
92 | regulation of cellular amine metabolic process (GO:0033238) | 3.09355926 |
93 | respiratory electron transport chain (GO:0022904) | 3.09113252 |
94 | transcription from RNA polymerase I promoter (GO:0006360) | 3.07723108 |
95 | electron transport chain (GO:0022900) | 3.07208033 |
96 | transcription from mitochondrial promoter (GO:0006390) | 3.07014502 |
97 | peptidyl-histidine modification (GO:0018202) | 3.06215955 |
98 | histone exchange (GO:0043486) | 3.04397883 |
99 | tRNA aminoacylation (GO:0043039) | 3.03774049 |
100 | amino acid activation (GO:0043038) | 3.03774049 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.76104009 |
2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.85583037 |
3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.78375062 |
4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.35836190 |
5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.81199411 |
6 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.52427352 |
7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.50489912 |
8 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.45982894 |
9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.38038466 |
10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.27423689 |
11 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.04574756 |
12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.92700819 |
13 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.89475004 |
14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.85790902 |
15 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.64934685 |
16 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.63079493 |
17 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.56241766 |
18 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.54363067 |
19 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.48830050 |
20 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.47412176 |
21 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.38767857 |
22 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.36511832 |
23 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.35052043 |
24 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.33446186 |
25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.26303804 |
26 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.25520573 |
27 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.12834343 |
28 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.09824396 |
29 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.04448592 |
30 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.97251512 |
31 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.96345130 |
32 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.94614247 |
33 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.92427155 |
34 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.91716261 |
35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.90774128 |
36 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.90186361 |
37 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.89318401 |
38 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.86064555 |
39 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.82700336 |
40 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.82654350 |
41 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.80826319 |
42 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.79740913 |
43 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.73772693 |
44 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.69689388 |
45 | VDR_22108803_ChIP-Seq_LS180_Human | 1.65884614 |
46 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.61253648 |
47 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.60395907 |
48 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.58698000 |
49 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.58067342 |
50 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.56636843 |
51 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.56164540 |
52 | EWS_26573619_Chip-Seq_HEK293_Human | 1.51922296 |
53 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.41844306 |
54 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.38743420 |
55 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.38375926 |
56 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.35355625 |
57 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.34085515 |
58 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.30607325 |
59 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.26663628 |
60 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.25998939 |
61 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.23515566 |
62 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.23483956 |
63 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.10168433 |
64 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.07746752 |
65 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.07715556 |
66 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.05291667 |
67 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.05075231 |
68 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.04184280 |
69 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.03786873 |
70 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.02191742 |
71 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.97898251 |
72 | FUS_26573619_Chip-Seq_HEK293_Human | 0.97577829 |
73 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.97007506 |
74 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95302124 |
75 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95165658 |
76 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.93658439 |
77 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.92850135 |
78 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.91832407 |
79 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.90964951 |
80 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.88950565 |
81 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.85026741 |
82 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.84529563 |
83 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.81281632 |
84 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.80120342 |
85 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.79472017 |
86 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.78504518 |
87 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.77507778 |
88 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.76723957 |
89 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.72482686 |
90 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.71064660 |
91 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.70539107 |
92 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.70318016 |
93 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.70241811 |
94 | P300_19829295_ChIP-Seq_ESCs_Human | 0.70004314 |
95 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.69644904 |
96 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.69644904 |
97 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.69170152 |
98 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.68123773 |
99 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.66577622 |
100 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.66271762 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003693_abnormal_embryo_hatching | 4.03201070 |
2 | MP0008058_abnormal_DNA_repair | 3.86939399 |
3 | MP0010094_abnormal_chromosome_stability | 3.77635388 |
4 | MP0004957_abnormal_blastocyst_morpholog | 3.60279385 |
5 | MP0001873_stomach_inflammation | 2.81970660 |
6 | MP0003111_abnormal_nucleus_morphology | 2.70113398 |
7 | MP0003718_maternal_effect | 2.65566075 |
8 | MP0002102_abnormal_ear_morphology | 2.52816554 |
9 | MP0003806_abnormal_nucleotide_metabolis | 2.52325388 |
10 | MP0003077_abnormal_cell_cycle | 2.38862137 |
11 | MP0001835_abnormal_antigen_presentation | 2.23472886 |
12 | MP0004147_increased_porphyrin_level | 2.22286846 |
13 | MP0002938_white_spotting | 2.19157458 |
14 | MP0008007_abnormal_cellular_replicative | 2.15928390 |
15 | MP0005084_abnormal_gallbladder_morpholo | 2.14122598 |
16 | MP0003186_abnormal_redox_activity | 2.14078528 |
17 | MP0003786_premature_aging | 2.07527630 |
18 | MP0001348_abnormal_lacrimal_gland | 2.00990421 |
19 | MP0008875_abnormal_xenobiotic_pharmacok | 1.93984841 |
20 | MP0008057_abnormal_DNA_replication | 1.92029064 |
21 | MP0008872_abnormal_physiological_respon | 1.89415993 |
22 | MP0002736_abnormal_nociception_after | 1.84568787 |
23 | MP0003195_calcinosis | 1.82865615 |
24 | MP0009697_abnormal_copulation | 1.80126908 |
25 | MP0006036_abnormal_mitochondrial_physio | 1.79895158 |
26 | MP0008877_abnormal_DNA_methylation | 1.79215060 |
27 | MP0006292_abnormal_olfactory_placode | 1.78747658 |
28 | MP0001529_abnormal_vocalization | 1.74886103 |
29 | MP0008932_abnormal_embryonic_tissue | 1.72479103 |
30 | MP0006035_abnormal_mitochondrial_morpho | 1.72127535 |
31 | MP0006072_abnormal_retinal_apoptosis | 1.69420346 |
32 | MP0002138_abnormal_hepatobiliary_system | 1.56393614 |
33 | MP0003567_abnormal_fetal_cardiomyocyte | 1.56171117 |
34 | MP0001188_hyperpigmentation | 1.50727353 |
35 | MP0009379_abnormal_foot_pigmentation | 1.48218903 |
36 | MP0002638_abnormal_pupillary_reflex | 1.43448334 |
37 | MP0004145_abnormal_muscle_electrophysio | 1.41806622 |
38 | MP0001984_abnormal_olfaction | 1.37003733 |
39 | MP0009333_abnormal_splenocyte_physiolog | 1.36515933 |
40 | MP0001293_anophthalmia | 1.35174295 |
41 | MP0005408_hypopigmentation | 1.34764683 |
42 | MP0005671_abnormal_response_to | 1.34501344 |
43 | MP0001730_embryonic_growth_arrest | 1.29537367 |
44 | MP0000372_irregular_coat_pigmentation | 1.28633106 |
45 | MP0000685_abnormal_immune_system | 1.27906829 |
46 | MP0003941_abnormal_skin_development | 1.26076082 |
47 | MP0002163_abnormal_gland_morphology | 1.24058100 |
48 | MP0001790_abnormal_immune_system | 1.22175386 |
49 | MP0005387_immune_system_phenotype | 1.22175386 |
50 | MP0002234_abnormal_pharynx_morphology | 1.20448815 |
51 | MP0001853_heart_inflammation | 1.19082422 |
52 | MP0004142_abnormal_muscle_tone | 1.18749884 |
53 | MP0002277_abnormal_respiratory_mucosa | 1.13738369 |
54 | MP0004742_abnormal_vestibular_system | 1.11543521 |
55 | MP0001968_abnormal_touch/_nociception | 1.06189874 |
56 | MP0001697_abnormal_embryo_size | 1.03092271 |
57 | MP0000490_abnormal_crypts_of | 1.01428122 |
58 | MP0002837_dystrophic_cardiac_calcinosis | 1.01111924 |
59 | MP0001881_abnormal_mammary_gland | 1.00632211 |
60 | MP0005379_endocrine/exocrine_gland_phen | 0.99708264 |
61 | MP0003890_abnormal_embryonic-extraembry | 0.95669449 |
62 | MP0002210_abnormal_sex_determination | 0.94609723 |
63 | MP0000358_abnormal_cell_content/ | 0.91850896 |
64 | MP0002148_abnormal_hypersensitivity_rea | 0.88906298 |
65 | MP0002006_tumorigenesis | 0.88417980 |
66 | MP0005310_abnormal_salivary_gland | 0.87333341 |
67 | MP0000350_abnormal_cell_proliferation | 0.86918473 |
68 | MP0000313_abnormal_cell_death | 0.86186849 |
69 | MP0001764_abnormal_homeostasis | 0.85476949 |
70 | MP0003936_abnormal_reproductive_system | 0.83359219 |
71 | MP0001919_abnormal_reproductive_system | 0.82691540 |
72 | MP0001672_abnormal_embryogenesis/_devel | 0.81646954 |
73 | MP0005380_embryogenesis_phenotype | 0.81646954 |
74 | MP0005253_abnormal_eye_physiology | 0.81073951 |
75 | MP0004782_abnormal_surfactant_physiolog | 0.80954390 |
76 | MP0005395_other_phenotype | 0.79938104 |
77 | MP0003315_abnormal_perineum_morphology | 0.79280735 |
78 | MP0001929_abnormal_gametogenesis | 0.78031861 |
79 | MP0002080_prenatal_lethality | 0.77414337 |
80 | MP0002085_abnormal_embryonic_tissue | 0.76528161 |
81 | MP0008789_abnormal_olfactory_epithelium | 0.75954802 |
82 | MP0005636_abnormal_mineral_homeostasis | 0.75671104 |
83 | MP0003937_abnormal_limbs/digits/tail_de | 0.74756977 |
84 | MP0005551_abnormal_eye_electrophysiolog | 0.74382922 |
85 | MP0002751_abnormal_autonomic_nervous | 0.72254828 |
86 | MP0000653_abnormal_sex_gland | 0.71476495 |
87 | MP0009672_abnormal_birth_weight | 0.69983572 |
88 | MP0001286_abnormal_eye_development | 0.69971661 |
89 | MP0002166_altered_tumor_susceptibility | 0.69950680 |
90 | MP0002019_abnormal_tumor_incidence | 0.68657217 |
91 | MP0000631_abnormal_neuroendocrine_gland | 0.68502135 |
92 | MP0005389_reproductive_system_phenotype | 0.68021020 |
93 | MP0003011_delayed_dark_adaptation | 0.67537601 |
94 | MP0009785_altered_susceptibility_to | 0.66601476 |
95 | MP0002088_abnormal_embryonic_growth/wei | 0.66312011 |
96 | MP0001485_abnormal_pinna_reflex | 0.65745288 |
97 | MP0008873_increased_physiological_sensi | 0.64991307 |
98 | MP0001145_abnormal_male_reproductive | 0.63932478 |
99 | MP0003984_embryonic_growth_retardation | 0.63697139 |
100 | MP0003943_abnormal_hepatobiliary_system | 0.63651972 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Increased hepatocellular lipid droplets (HP:0006565) | 5.43204423 |
2 | Acute necrotizing encephalopathy (HP:0006965) | 5.04391808 |
3 | Lipid accumulation in hepatocytes (HP:0006561) | 4.93562982 |
4 | Mitochondrial inheritance (HP:0001427) | 4.66098930 |
5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.45142185 |
6 | Acute encephalopathy (HP:0006846) | 4.43958417 |
7 | Increased CSF lactate (HP:0002490) | 4.39515524 |
8 | Progressive macrocephaly (HP:0004481) | 4.06326136 |
9 | Renal Fanconi syndrome (HP:0001994) | 3.99457064 |
10 | Hepatocellular necrosis (HP:0001404) | 3.78285381 |
11 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.61910863 |
12 | Exertional dyspnea (HP:0002875) | 3.60760500 |
13 | Hepatic necrosis (HP:0002605) | 3.56527895 |
14 | Increased intramyocellular lipid droplets (HP:0012240) | 3.48937869 |
15 | Cerebral edema (HP:0002181) | 3.35224576 |
16 | Increased serum lactate (HP:0002151) | 3.34515084 |
17 | Abnormality of the labia minora (HP:0012880) | 3.24842473 |
18 | Abnormality of the pons (HP:0007361) | 3.22605636 |
19 | Respiratory difficulties (HP:0002880) | 3.05036931 |
20 | Exercise intolerance (HP:0003546) | 3.00867749 |
21 | Increased serum pyruvate (HP:0003542) | 2.97905504 |
22 | Colon cancer (HP:0003003) | 2.97622391 |
23 | Hypoplasia of the pons (HP:0012110) | 2.96983251 |
24 | Type I transferrin isoform profile (HP:0003642) | 2.91944806 |
25 | Abnormality of glycolysis (HP:0004366) | 2.88817420 |
26 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.88533658 |
27 | Leukodystrophy (HP:0002415) | 2.82147978 |
28 | Increased muscle lipid content (HP:0009058) | 2.81801649 |
29 | Methylmalonic acidemia (HP:0002912) | 2.80409672 |
30 | Lactic acidosis (HP:0003128) | 2.73290567 |
31 | Oral leukoplakia (HP:0002745) | 2.66990516 |
32 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.66572314 |
33 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.66572314 |
34 | Optic disc pallor (HP:0000543) | 2.55483643 |
35 | Meckel diverticulum (HP:0002245) | 2.52574724 |
36 | IgG deficiency (HP:0004315) | 2.51195755 |
37 | Abnormality of renal resorption (HP:0011038) | 2.48695865 |
38 | Abnormality of methionine metabolism (HP:0010901) | 2.48380210 |
39 | Reticulocytopenia (HP:0001896) | 2.48135420 |
40 | Abnormality of the ileum (HP:0001549) | 2.47892417 |
41 | Methylmalonic aciduria (HP:0012120) | 2.47177632 |
42 | Respiratory failure (HP:0002878) | 2.46331649 |
43 | Congenital, generalized hypertrichosis (HP:0004540) | 2.45417825 |
44 | Reduced antithrombin III activity (HP:0001976) | 2.44371866 |
45 | Aplastic anemia (HP:0001915) | 2.42744089 |
46 | Microvesicular hepatic steatosis (HP:0001414) | 2.40049794 |
47 | Pendular nystagmus (HP:0012043) | 2.37927030 |
48 | Stomatitis (HP:0010280) | 2.36791880 |
49 | 3-Methylglutaconic aciduria (HP:0003535) | 2.35746986 |
50 | Abnormality of the preputium (HP:0100587) | 2.34802524 |
51 | Abnormal protein glycosylation (HP:0012346) | 2.34485137 |
52 | Abnormal glycosylation (HP:0012345) | 2.34485137 |
53 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.34485137 |
54 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.34485137 |
55 | Cerebral hypomyelination (HP:0006808) | 2.34225527 |
56 | Abnormality of urine glucose concentration (HP:0011016) | 2.28754855 |
57 | Glycosuria (HP:0003076) | 2.28754855 |
58 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.27901282 |
59 | Hyperphosphaturia (HP:0003109) | 2.26878204 |
60 | Macrocytic anemia (HP:0001972) | 2.24754934 |
61 | Abnormality of the anterior horn cell (HP:0006802) | 2.23054771 |
62 | Degeneration of anterior horn cells (HP:0002398) | 2.23054771 |
63 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.22053476 |
64 | Pancreatic cysts (HP:0001737) | 2.20688718 |
65 | Lethargy (HP:0001254) | 2.20667441 |
66 | Pancytopenia (HP:0001876) | 2.06495744 |
67 | CNS demyelination (HP:0007305) | 2.04576091 |
68 | Megaloblastic anemia (HP:0001889) | 2.03960832 |
69 | Abnormality of chromosome stability (HP:0003220) | 2.03448885 |
70 | Amniotic constriction ring (HP:0009775) | 2.02840411 |
71 | Abnormality of placental membranes (HP:0011409) | 2.02840411 |
72 | Abnormality of alanine metabolism (HP:0010916) | 2.02032718 |
73 | Hyperalaninemia (HP:0003348) | 2.02032718 |
74 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.02032718 |
75 | IgA deficiency (HP:0002720) | 1.94794067 |
76 | Abnormality of serum amino acid levels (HP:0003112) | 1.93537068 |
77 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.89294424 |
78 | Small intestinal stenosis (HP:0012848) | 1.86701850 |
79 | Duodenal stenosis (HP:0100867) | 1.86701850 |
80 | Generalized aminoaciduria (HP:0002909) | 1.86287553 |
81 | Absent thumb (HP:0009777) | 1.85663086 |
82 | Hyperglycinuria (HP:0003108) | 1.84766965 |
83 | Increased IgM level (HP:0003496) | 1.81401789 |
84 | Abnormal lung lobation (HP:0002101) | 1.79919259 |
85 | Abnormality of homocysteine metabolism (HP:0010919) | 1.75326182 |
86 | Homocystinuria (HP:0002156) | 1.75326182 |
87 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.73918243 |
88 | Duplicated collecting system (HP:0000081) | 1.73435710 |
89 | Testicular atrophy (HP:0000029) | 1.71664588 |
90 | Clubbing of toes (HP:0100760) | 1.71541023 |
91 | Horseshoe kidney (HP:0000085) | 1.71488914 |
92 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.68827110 |
93 | Chromsome breakage (HP:0040012) | 1.67919429 |
94 | Neoplasm of the adrenal gland (HP:0100631) | 1.66828725 |
95 | Abnormality of glycine metabolism (HP:0010895) | 1.64332122 |
96 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.64332122 |
97 | Abnormality of the carotid arteries (HP:0005344) | 1.63953002 |
98 | Abnormality of the renal collecting system (HP:0004742) | 1.63169106 |
99 | Ependymoma (HP:0002888) | 1.61547748 |
100 | Triphalangeal thumb (HP:0001199) | 1.61354452 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TSSK6 | 4.88577319 |
2 | BUB1 | 3.88252772 |
3 | EIF2AK3 | 3.79904195 |
4 | VRK2 | 3.70308394 |
5 | ZAK | 3.68409785 |
6 | MST4 | 3.48409465 |
7 | EIF2AK1 | 3.24467615 |
8 | PBK | 2.91413547 |
9 | SRPK1 | 2.73695899 |
10 | NEK1 | 2.68093404 |
11 | NUAK1 | 2.52300562 |
12 | NME1 | 2.48894904 |
13 | VRK1 | 2.44808273 |
14 | CDC7 | 2.37661169 |
15 | PLK3 | 2.26182406 |
16 | STK16 | 1.88272378 |
17 | TAF1 | 1.82552642 |
18 | TLK1 | 1.77962448 |
19 | MKNK2 | 1.77771514 |
20 | TTK | 1.72825367 |
21 | MKNK1 | 1.64990722 |
22 | WNK3 | 1.50390493 |
23 | TRIM28 | 1.50280770 |
24 | PLK4 | 1.46760697 |
25 | BMPR1B | 1.44178098 |
26 | EIF2AK2 | 1.35735149 |
27 | WEE1 | 1.31701775 |
28 | TNIK | 1.23347586 |
29 | PASK | 1.19027115 |
30 | PLK1 | 1.15207542 |
31 | OXSR1 | 1.14087063 |
32 | TXK | 1.14015167 |
33 | NME2 | 1.11219594 |
34 | ADRBK2 | 1.10398719 |
35 | ALK | 1.05963465 |
36 | GRK1 | 1.05322560 |
37 | STK4 | 1.00430012 |
38 | ATR | 0.94557011 |
39 | MAP4K2 | 0.89682329 |
40 | DYRK2 | 0.88594774 |
41 | MAP3K12 | 0.86522681 |
42 | STK39 | 0.82874191 |
43 | TAOK3 | 0.81933506 |
44 | PAK4 | 0.80033575 |
45 | TIE1 | 0.77513481 |
46 | DYRK3 | 0.71771352 |
47 | AURKB | 0.71582551 |
48 | WNK4 | 0.70933153 |
49 | PLK2 | 0.69005979 |
50 | CSNK2A2 | 0.63846686 |
51 | FGFR1 | 0.62911751 |
52 | ACVR1B | 0.62283762 |
53 | BCKDK | 0.59150139 |
54 | STK38L | 0.58604356 |
55 | DAPK1 | 0.56150776 |
56 | CHEK1 | 0.55455468 |
57 | CSNK2A1 | 0.53630292 |
58 | CSNK1G1 | 0.53545834 |
59 | RPS6KB2 | 0.53320469 |
60 | PNCK | 0.50826824 |
61 | PDK2 | 0.50680384 |
62 | BCR | 0.50237349 |
63 | SMG1 | 0.50141630 |
64 | ATM | 0.49692093 |
65 | PHKG2 | 0.46866117 |
66 | PHKG1 | 0.46866117 |
67 | MAPKAPK5 | 0.46195362 |
68 | CCNB1 | 0.46104687 |
69 | RPS6KA4 | 0.44761373 |
70 | CHEK2 | 0.43852349 |
71 | AURKA | 0.42890941 |
72 | RPS6KA5 | 0.41700476 |
73 | CSNK1E | 0.41586257 |
74 | CSNK1G3 | 0.41490817 |
75 | IKBKB | 0.40238883 |
76 | TGFBR1 | 0.39077198 |
77 | CSNK1A1L | 0.38521500 |
78 | DAPK3 | 0.38340935 |
79 | MAP3K4 | 0.37552858 |
80 | PRKCG | 0.36003650 |
81 | TEC | 0.34791630 |
82 | MAPKAPK3 | 0.32423035 |
83 | STK3 | 0.31483389 |
84 | NEK2 | 0.29352823 |
85 | CSNK1A1 | 0.28628256 |
86 | SIK3 | 0.28599045 |
87 | CDK7 | 0.27971404 |
88 | NEK9 | 0.27932482 |
89 | AKT2 | 0.26992089 |
90 | FRK | 0.26206865 |
91 | CDK1 | 0.24353618 |
92 | CSNK1G2 | 0.24324340 |
93 | BRD4 | 0.23358531 |
94 | MAP2K7 | 0.22992353 |
95 | PRKDC | 0.22247985 |
96 | NLK | 0.19257277 |
97 | INSRR | 0.19254716 |
98 | CDK2 | 0.17786957 |
99 | PAK3 | 0.16577197 |
100 | MAP2K6 | 0.16222611 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 5.70604154 |
2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.55657238 |
3 | Protein export_Homo sapiens_hsa03060 | 3.52220367 |
4 | Ribosome_Homo sapiens_hsa03010 | 3.05932405 |
5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.04840590 |
6 | RNA polymerase_Homo sapiens_hsa03020 | 3.04450621 |
7 | Mismatch repair_Homo sapiens_hsa03430 | 2.76112740 |
8 | DNA replication_Homo sapiens_hsa03030 | 2.66395413 |
9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.59963302 |
10 | Spliceosome_Homo sapiens_hsa03040 | 2.30144337 |
11 | RNA transport_Homo sapiens_hsa03013 | 2.17885584 |
12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.17180582 |
13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.15711068 |
14 | RNA degradation_Homo sapiens_hsa03018 | 2.08358536 |
15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.07988644 |
16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.07611728 |
17 | Homologous recombination_Homo sapiens_hsa03440 | 1.96227648 |
18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.86871298 |
19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.85081620 |
20 | Base excision repair_Homo sapiens_hsa03410 | 1.75849255 |
21 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.64391491 |
22 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.53204495 |
23 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.53078153 |
24 | Alzheimers disease_Homo sapiens_hsa05010 | 1.52004209 |
25 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.44121650 |
26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.42586629 |
27 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.34126634 |
28 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.32899858 |
29 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.25324640 |
30 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.24631004 |
31 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.21130995 |
32 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.20276171 |
33 | Purine metabolism_Homo sapiens_hsa00230 | 1.17754208 |
34 | Asthma_Homo sapiens_hsa05310 | 1.12672987 |
35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.12247500 |
36 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.07631620 |
37 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.04555395 |
38 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.90058338 |
39 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.89643374 |
40 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.87933611 |
41 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.86893673 |
42 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.86742755 |
43 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.86629120 |
44 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.84899612 |
45 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.83550549 |
46 | Cell cycle_Homo sapiens_hsa04110 | 0.83352449 |
47 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.81541879 |
48 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.79979496 |
49 | Sulfur relay system_Homo sapiens_hsa04122 | 0.79845954 |
50 | Allograft rejection_Homo sapiens_hsa05330 | 0.77229185 |
51 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.76259218 |
52 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.74245680 |
53 | Carbon metabolism_Homo sapiens_hsa01200 | 0.73846622 |
54 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.67392598 |
55 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.65737502 |
56 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.65122309 |
57 | Metabolic pathways_Homo sapiens_hsa01100 | 0.63114609 |
58 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.62034338 |
59 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.61922483 |
60 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.61457278 |
61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.61082812 |
62 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.58756456 |
63 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.58486736 |
64 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.58117351 |
65 | Peroxisome_Homo sapiens_hsa04146 | 0.57157663 |
66 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.57086357 |
67 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.56389441 |
68 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.55876584 |
69 | Phototransduction_Homo sapiens_hsa04744 | 0.50251570 |
70 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.48390216 |
71 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.46074700 |
72 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.44538466 |
73 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.43897140 |
74 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.41908941 |
75 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.41710255 |
76 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.41351479 |
77 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.41286213 |
78 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.40532737 |
79 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.40502242 |
80 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.35662509 |
81 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.35334865 |
82 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.34161966 |
83 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.34085250 |
84 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.32949413 |
85 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.31384671 |
86 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.30255146 |
87 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.29185064 |
88 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.28094611 |
89 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.27151635 |
90 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.25285244 |
91 | Alcoholism_Homo sapiens_hsa05034 | 0.22970017 |
92 | Measles_Homo sapiens_hsa05162 | 0.21416150 |
93 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.18819346 |
94 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.18532067 |
95 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.18031858 |
96 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.16882924 |
97 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.15579074 |
98 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.14999017 |
99 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.13540631 |
100 | Retinol metabolism_Homo sapiens_hsa00830 | 0.12619888 |