HSPD1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)5.22386025
2proteasome assembly (GO:0043248)5.09563083
3chaperone-mediated protein transport (GO:0072321)4.84799659
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.77228213
5ribosome assembly (GO:0042255)4.47947196
6positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.43911680
7regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.37644621
8negative regulation of ligase activity (GO:0051352)4.35583837
9negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.35583837
10regulation of cellular amino acid metabolic process (GO:0006521)4.32450728
11rRNA modification (GO:0000154)4.31198287
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26810198
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.20377709
14signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.19472394
15signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.19472394
16signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.19472394
17anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.17368336
18DNA deamination (GO:0045006)4.16994244
19maturation of 5.8S rRNA (GO:0000460)4.15068780
20signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.13503848
21intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.13503848
22cullin deneddylation (GO:0010388)4.07984883
23signal transduction involved in DNA integrity checkpoint (GO:0072401)4.07443819
24signal transduction involved in DNA damage checkpoint (GO:0072422)4.07443819
25ATP synthesis coupled proton transport (GO:0015986)4.03109190
26energy coupled proton transport, down electrochemical gradient (GO:0015985)4.03109190
27maturation of SSU-rRNA (GO:0030490)4.02501475
28signal transduction involved in cell cycle checkpoint (GO:0072395)4.00850856
29rRNA methylation (GO:0031167)3.93881820
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.92634906
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.87154429
32protein complex biogenesis (GO:0070271)3.86340033
33mitochondrial respiratory chain complex assembly (GO:0033108)3.84788505
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.84695274
35NADH dehydrogenase complex assembly (GO:0010257)3.84695274
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.84695274
37regulation of isotype switching to IgG isotypes (GO:0048302)3.81489490
38positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.81150938
39ribosomal large subunit biogenesis (GO:0042273)3.73502615
40protein deneddylation (GO:0000338)3.73308972
41rRNA processing (GO:0006364)3.69861040
42IMP biosynthetic process (GO:0006188)3.68184077
43termination of RNA polymerase I transcription (GO:0006363)3.67649151
44positive regulation of ligase activity (GO:0051351)3.65502305
45protein neddylation (GO:0045116)3.64141448
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.63944042
47termination of RNA polymerase III transcription (GO:0006386)3.63944042
48DNA double-strand break processing (GO:0000729)3.59539444
49pseudouridine synthesis (GO:0001522)3.57205324
50rRNA metabolic process (GO:0016072)3.56867523
51DNA catabolic process, exonucleolytic (GO:0000738)3.55230743
52regulation of immunoglobulin secretion (GO:0051023)3.55128182
53spliceosomal snRNP assembly (GO:0000387)3.55089380
54folic acid-containing compound biosynthetic process (GO:0009396)3.54807175
55transcription elongation from RNA polymerase I promoter (GO:0006362)3.52471747
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51510716
57somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.48596778
58isotype switching (GO:0045190)3.48596778
59somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.48596778
60chromatin remodeling at centromere (GO:0031055)3.46205170
617-methylguanosine mRNA capping (GO:0006370)3.46173453
62GTP biosynthetic process (GO:0006183)3.44497736
63DNA damage response, detection of DNA damage (GO:0042769)3.42008535
64CENP-A containing nucleosome assembly (GO:0034080)3.40470558
65water-soluble vitamin biosynthetic process (GO:0042364)3.39635819
66regulation of ubiquitin-protein transferase activity (GO:0051438)3.38635114
67pteridine-containing compound biosynthetic process (GO:0042559)3.38036922
687-methylguanosine RNA capping (GO:0009452)3.37170847
69RNA capping (GO:0036260)3.37170847
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.34652652
71ribosome biogenesis (GO:0042254)3.32011640
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31825998
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31825998
74positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.28616034
75IMP metabolic process (GO:0046040)3.28456224
76DNA replication checkpoint (GO:0000076)3.27949689
77regulation of ligase activity (GO:0051340)3.27313185
78ribonucleoprotein complex biogenesis (GO:0022613)3.24554529
79cellular component biogenesis (GO:0044085)3.24433450
80positive regulation of cell cycle arrest (GO:0071158)3.22942904
81translation (GO:0006412)3.21706378
82UTP biosynthetic process (GO:0006228)3.19230020
83formation of translation preinitiation complex (GO:0001731)3.16583600
84histone mRNA metabolic process (GO:0008334)3.16527022
85protein targeting to mitochondrion (GO:0006626)3.15965053
86mitochondrial RNA metabolic process (GO:0000959)3.14488663
87regulation of chronic inflammatory response (GO:0002676)3.13128630
88establishment of integrated proviral latency (GO:0075713)3.12751812
89nucleobase biosynthetic process (GO:0046112)3.12467620
90negative regulation of protein ubiquitination (GO:0031397)3.11067115
91DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.10444289
92regulation of cellular amine metabolic process (GO:0033238)3.09355926
93respiratory electron transport chain (GO:0022904)3.09113252
94transcription from RNA polymerase I promoter (GO:0006360)3.07723108
95electron transport chain (GO:0022900)3.07208033
96transcription from mitochondrial promoter (GO:0006390)3.07014502
97peptidyl-histidine modification (GO:0018202)3.06215955
98histone exchange (GO:0043486)3.04397883
99tRNA aminoacylation (GO:0043039)3.03774049
100amino acid activation (GO:0043038)3.03774049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.76104009
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.85583037
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.78375062
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.35836190
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.81199411
6E2F7_22180533_ChIP-Seq_HELA_Human3.52427352
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.50489912
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45982894
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.38038466
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.27423689
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.04574756
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.92700819
13ELK1_19687146_ChIP-ChIP_HELA_Human2.89475004
14VDR_23849224_ChIP-Seq_CD4+_Human2.85790902
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64934685
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63079493
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56241766
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54363067
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48830050
20FOXP3_21729870_ChIP-Seq_TREG_Human2.47412176
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38767857
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36511832
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35052043
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33446186
25DCP1A_22483619_ChIP-Seq_HELA_Human2.26303804
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25520573
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12834343
28PADI4_21655091_ChIP-ChIP_MCF-7_Human2.09824396
29TTF2_22483619_ChIP-Seq_HELA_Human2.04448592
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.97251512
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96345130
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94614247
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.92427155
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91716261
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90774128
36XRN2_22483619_ChIP-Seq_HELA_Human1.90186361
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.89318401
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86064555
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82700336
40GABP_19822575_ChIP-Seq_HepG2_Human1.82654350
41MYC_18940864_ChIP-ChIP_HL60_Human1.80826319
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.79740913
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.73772693
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69689388
45VDR_22108803_ChIP-Seq_LS180_Human1.65884614
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61253648
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60395907
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58698000
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58067342
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56636843
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56164540
52EWS_26573619_Chip-Seq_HEK293_Human1.51922296
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41844306
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38743420
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.38375926
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35355625
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.34085515
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30607325
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26663628
60AR_21909140_ChIP-Seq_LNCAP_Human1.25998939
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.23515566
62ZNF274_21170338_ChIP-Seq_K562_Hela1.23483956
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10168433
64KDM5A_27292631_Chip-Seq_BREAST_Human1.07746752
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07715556
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05291667
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05075231
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.04184280
69IRF1_19129219_ChIP-ChIP_H3396_Human1.03786873
70TP53_22573176_ChIP-Seq_HFKS_Human1.02191742
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97898251
72FUS_26573619_Chip-Seq_HEK293_Human0.97577829
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97007506
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95302124
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95165658
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93658439
77SOX2_16153702_ChIP-ChIP_HESCs_Human0.92850135
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91832407
79ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90964951
80NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88950565
81SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85026741
82ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84529563
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81281632
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80120342
85NFE2_27457419_Chip-Seq_LIVER_Mouse0.79472017
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78504518
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77507778
88SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76723957
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72482686
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71064660
91TAF15_26573619_Chip-Seq_HEK293_Human0.70539107
92PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70318016
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.70241811
94P300_19829295_ChIP-Seq_ESCs_Human0.70004314
95NANOG_19829295_ChIP-Seq_ESCs_Human0.69644904
96SOX2_19829295_ChIP-Seq_ESCs_Human0.69644904
97ELF5_23300383_ChIP-Seq_T47D_Human0.69170152
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.68123773
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66577622
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66271762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.03201070
2MP0008058_abnormal_DNA_repair3.86939399
3MP0010094_abnormal_chromosome_stability3.77635388
4MP0004957_abnormal_blastocyst_morpholog3.60279385
5MP0001873_stomach_inflammation2.81970660
6MP0003111_abnormal_nucleus_morphology2.70113398
7MP0003718_maternal_effect2.65566075
8MP0002102_abnormal_ear_morphology2.52816554
9MP0003806_abnormal_nucleotide_metabolis2.52325388
10MP0003077_abnormal_cell_cycle2.38862137
11MP0001835_abnormal_antigen_presentation2.23472886
12MP0004147_increased_porphyrin_level2.22286846
13MP0002938_white_spotting2.19157458
14MP0008007_abnormal_cellular_replicative2.15928390
15MP0005084_abnormal_gallbladder_morpholo2.14122598
16MP0003186_abnormal_redox_activity2.14078528
17MP0003786_premature_aging2.07527630
18MP0001348_abnormal_lacrimal_gland2.00990421
19MP0008875_abnormal_xenobiotic_pharmacok1.93984841
20MP0008057_abnormal_DNA_replication1.92029064
21MP0008872_abnormal_physiological_respon1.89415993
22MP0002736_abnormal_nociception_after1.84568787
23MP0003195_calcinosis1.82865615
24MP0009697_abnormal_copulation1.80126908
25MP0006036_abnormal_mitochondrial_physio1.79895158
26MP0008877_abnormal_DNA_methylation1.79215060
27MP0006292_abnormal_olfactory_placode1.78747658
28MP0001529_abnormal_vocalization1.74886103
29MP0008932_abnormal_embryonic_tissue1.72479103
30MP0006035_abnormal_mitochondrial_morpho1.72127535
31MP0006072_abnormal_retinal_apoptosis1.69420346
32MP0002138_abnormal_hepatobiliary_system1.56393614
33MP0003567_abnormal_fetal_cardiomyocyte1.56171117
34MP0001188_hyperpigmentation1.50727353
35MP0009379_abnormal_foot_pigmentation1.48218903
36MP0002638_abnormal_pupillary_reflex1.43448334
37MP0004145_abnormal_muscle_electrophysio1.41806622
38MP0001984_abnormal_olfaction1.37003733
39MP0009333_abnormal_splenocyte_physiolog1.36515933
40MP0001293_anophthalmia1.35174295
41MP0005408_hypopigmentation1.34764683
42MP0005671_abnormal_response_to1.34501344
43MP0001730_embryonic_growth_arrest1.29537367
44MP0000372_irregular_coat_pigmentation1.28633106
45MP0000685_abnormal_immune_system1.27906829
46MP0003941_abnormal_skin_development1.26076082
47MP0002163_abnormal_gland_morphology1.24058100
48MP0001790_abnormal_immune_system1.22175386
49MP0005387_immune_system_phenotype1.22175386
50MP0002234_abnormal_pharynx_morphology1.20448815
51MP0001853_heart_inflammation1.19082422
52MP0004142_abnormal_muscle_tone1.18749884
53MP0002277_abnormal_respiratory_mucosa1.13738369
54MP0004742_abnormal_vestibular_system1.11543521
55MP0001968_abnormal_touch/_nociception1.06189874
56MP0001697_abnormal_embryo_size1.03092271
57MP0000490_abnormal_crypts_of1.01428122
58MP0002837_dystrophic_cardiac_calcinosis1.01111924
59MP0001881_abnormal_mammary_gland1.00632211
60MP0005379_endocrine/exocrine_gland_phen0.99708264
61MP0003890_abnormal_embryonic-extraembry0.95669449
62MP0002210_abnormal_sex_determination0.94609723
63MP0000358_abnormal_cell_content/0.91850896
64MP0002148_abnormal_hypersensitivity_rea0.88906298
65MP0002006_tumorigenesis0.88417980
66MP0005310_abnormal_salivary_gland0.87333341
67MP0000350_abnormal_cell_proliferation0.86918473
68MP0000313_abnormal_cell_death0.86186849
69MP0001764_abnormal_homeostasis0.85476949
70MP0003936_abnormal_reproductive_system0.83359219
71MP0001919_abnormal_reproductive_system0.82691540
72MP0001672_abnormal_embryogenesis/_devel0.81646954
73MP0005380_embryogenesis_phenotype0.81646954
74MP0005253_abnormal_eye_physiology0.81073951
75MP0004782_abnormal_surfactant_physiolog0.80954390
76MP0005395_other_phenotype0.79938104
77MP0003315_abnormal_perineum_morphology0.79280735
78MP0001929_abnormal_gametogenesis0.78031861
79MP0002080_prenatal_lethality0.77414337
80MP0002085_abnormal_embryonic_tissue0.76528161
81MP0008789_abnormal_olfactory_epithelium0.75954802
82MP0005636_abnormal_mineral_homeostasis0.75671104
83MP0003937_abnormal_limbs/digits/tail_de0.74756977
84MP0005551_abnormal_eye_electrophysiolog0.74382922
85MP0002751_abnormal_autonomic_nervous0.72254828
86MP0000653_abnormal_sex_gland0.71476495
87MP0009672_abnormal_birth_weight0.69983572
88MP0001286_abnormal_eye_development0.69971661
89MP0002166_altered_tumor_susceptibility0.69950680
90MP0002019_abnormal_tumor_incidence0.68657217
91MP0000631_abnormal_neuroendocrine_gland0.68502135
92MP0005389_reproductive_system_phenotype0.68021020
93MP0003011_delayed_dark_adaptation0.67537601
94MP0009785_altered_susceptibility_to0.66601476
95MP0002088_abnormal_embryonic_growth/wei0.66312011
96MP0001485_abnormal_pinna_reflex0.65745288
97MP0008873_increased_physiological_sensi0.64991307
98MP0001145_abnormal_male_reproductive0.63932478
99MP0003984_embryonic_growth_retardation0.63697139
100MP0003943_abnormal_hepatobiliary_system0.63651972

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)5.43204423
2Acute necrotizing encephalopathy (HP:0006965)5.04391808
3Lipid accumulation in hepatocytes (HP:0006561)4.93562982
4Mitochondrial inheritance (HP:0001427)4.66098930
5Abnormal mitochondria in muscle tissue (HP:0008316)4.45142185
6Acute encephalopathy (HP:0006846)4.43958417
7Increased CSF lactate (HP:0002490)4.39515524
8Progressive macrocephaly (HP:0004481)4.06326136
9Renal Fanconi syndrome (HP:0001994)3.99457064
10Hepatocellular necrosis (HP:0001404)3.78285381
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.61910863
12Exertional dyspnea (HP:0002875)3.60760500
13Hepatic necrosis (HP:0002605)3.56527895
14Increased intramyocellular lipid droplets (HP:0012240)3.48937869
15Cerebral edema (HP:0002181)3.35224576
16Increased serum lactate (HP:0002151)3.34515084
17Abnormality of the labia minora (HP:0012880)3.24842473
18Abnormality of the pons (HP:0007361)3.22605636
19Respiratory difficulties (HP:0002880)3.05036931
20Exercise intolerance (HP:0003546)3.00867749
21Increased serum pyruvate (HP:0003542)2.97905504
22Colon cancer (HP:0003003)2.97622391
23Hypoplasia of the pons (HP:0012110)2.96983251
24Type I transferrin isoform profile (HP:0003642)2.91944806
25Abnormality of glycolysis (HP:0004366)2.88817420
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.88533658
27Leukodystrophy (HP:0002415)2.82147978
28Increased muscle lipid content (HP:0009058)2.81801649
29Methylmalonic acidemia (HP:0002912)2.80409672
30Lactic acidosis (HP:0003128)2.73290567
31Oral leukoplakia (HP:0002745)2.66990516
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66572314
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66572314
34Optic disc pallor (HP:0000543)2.55483643
35Meckel diverticulum (HP:0002245)2.52574724
36IgG deficiency (HP:0004315)2.51195755
37Abnormality of renal resorption (HP:0011038)2.48695865
38Abnormality of methionine metabolism (HP:0010901)2.48380210
39Reticulocytopenia (HP:0001896)2.48135420
40Abnormality of the ileum (HP:0001549)2.47892417
41Methylmalonic aciduria (HP:0012120)2.47177632
42Respiratory failure (HP:0002878)2.46331649
43Congenital, generalized hypertrichosis (HP:0004540)2.45417825
44Reduced antithrombin III activity (HP:0001976)2.44371866
45Aplastic anemia (HP:0001915)2.42744089
46Microvesicular hepatic steatosis (HP:0001414)2.40049794
47Pendular nystagmus (HP:0012043)2.37927030
48Stomatitis (HP:0010280)2.36791880
493-Methylglutaconic aciduria (HP:0003535)2.35746986
50Abnormality of the preputium (HP:0100587)2.34802524
51Abnormal protein glycosylation (HP:0012346)2.34485137
52Abnormal glycosylation (HP:0012345)2.34485137
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34485137
54Abnormal protein N-linked glycosylation (HP:0012347)2.34485137
55Cerebral hypomyelination (HP:0006808)2.34225527
56Abnormality of urine glucose concentration (HP:0011016)2.28754855
57Glycosuria (HP:0003076)2.28754855
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27901282
59Hyperphosphaturia (HP:0003109)2.26878204
60Macrocytic anemia (HP:0001972)2.24754934
61Abnormality of the anterior horn cell (HP:0006802)2.23054771
62Degeneration of anterior horn cells (HP:0002398)2.23054771
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.22053476
64Pancreatic cysts (HP:0001737)2.20688718
65Lethargy (HP:0001254)2.20667441
66Pancytopenia (HP:0001876)2.06495744
67CNS demyelination (HP:0007305)2.04576091
68Megaloblastic anemia (HP:0001889)2.03960832
69Abnormality of chromosome stability (HP:0003220)2.03448885
70Amniotic constriction ring (HP:0009775)2.02840411
71Abnormality of placental membranes (HP:0011409)2.02840411
72Abnormality of alanine metabolism (HP:0010916)2.02032718
73Hyperalaninemia (HP:0003348)2.02032718
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02032718
75IgA deficiency (HP:0002720)1.94794067
76Abnormality of serum amino acid levels (HP:0003112)1.93537068
77Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89294424
78Small intestinal stenosis (HP:0012848)1.86701850
79Duodenal stenosis (HP:0100867)1.86701850
80Generalized aminoaciduria (HP:0002909)1.86287553
81Absent thumb (HP:0009777)1.85663086
82Hyperglycinuria (HP:0003108)1.84766965
83Increased IgM level (HP:0003496)1.81401789
84Abnormal lung lobation (HP:0002101)1.79919259
85Abnormality of homocysteine metabolism (HP:0010919)1.75326182
86Homocystinuria (HP:0002156)1.75326182
87Aplasia/hypoplasia of the uterus (HP:0008684)1.73918243
88Duplicated collecting system (HP:0000081)1.73435710
89Testicular atrophy (HP:0000029)1.71664588
90Clubbing of toes (HP:0100760)1.71541023
91Horseshoe kidney (HP:0000085)1.71488914
92Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.68827110
93Chromsome breakage (HP:0040012)1.67919429
94Neoplasm of the adrenal gland (HP:0100631)1.66828725
95Abnormality of glycine metabolism (HP:0010895)1.64332122
96Abnormality of serine family amino acid metabolism (HP:0010894)1.64332122
97Abnormality of the carotid arteries (HP:0005344)1.63953002
98Abnormality of the renal collecting system (HP:0004742)1.63169106
99Ependymoma (HP:0002888)1.61547748
100Triphalangeal thumb (HP:0001199)1.61354452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.88577319
2BUB13.88252772
3EIF2AK33.79904195
4VRK23.70308394
5ZAK3.68409785
6MST43.48409465
7EIF2AK13.24467615
8PBK2.91413547
9SRPK12.73695899
10NEK12.68093404
11NUAK12.52300562
12NME12.48894904
13VRK12.44808273
14CDC72.37661169
15PLK32.26182406
16STK161.88272378
17TAF11.82552642
18TLK11.77962448
19MKNK21.77771514
20TTK1.72825367
21MKNK11.64990722
22WNK31.50390493
23TRIM281.50280770
24PLK41.46760697
25BMPR1B1.44178098
26EIF2AK21.35735149
27WEE11.31701775
28TNIK1.23347586
29PASK1.19027115
30PLK11.15207542
31OXSR11.14087063
32TXK1.14015167
33NME21.11219594
34ADRBK21.10398719
35ALK1.05963465
36GRK11.05322560
37STK41.00430012
38ATR0.94557011
39MAP4K20.89682329
40DYRK20.88594774
41MAP3K120.86522681
42STK390.82874191
43TAOK30.81933506
44PAK40.80033575
45TIE10.77513481
46DYRK30.71771352
47AURKB0.71582551
48WNK40.70933153
49PLK20.69005979
50CSNK2A20.63846686
51FGFR10.62911751
52ACVR1B0.62283762
53BCKDK0.59150139
54STK38L0.58604356
55DAPK10.56150776
56CHEK10.55455468
57CSNK2A10.53630292
58CSNK1G10.53545834
59RPS6KB20.53320469
60PNCK0.50826824
61PDK20.50680384
62BCR0.50237349
63SMG10.50141630
64ATM0.49692093
65PHKG20.46866117
66PHKG10.46866117
67MAPKAPK50.46195362
68CCNB10.46104687
69RPS6KA40.44761373
70CHEK20.43852349
71AURKA0.42890941
72RPS6KA50.41700476
73CSNK1E0.41586257
74CSNK1G30.41490817
75IKBKB0.40238883
76TGFBR10.39077198
77CSNK1A1L0.38521500
78DAPK30.38340935
79MAP3K40.37552858
80PRKCG0.36003650
81TEC0.34791630
82MAPKAPK30.32423035
83STK30.31483389
84NEK20.29352823
85CSNK1A10.28628256
86SIK30.28599045
87CDK70.27971404
88NEK90.27932482
89AKT20.26992089
90FRK0.26206865
91CDK10.24353618
92CSNK1G20.24324340
93BRD40.23358531
94MAP2K70.22992353
95PRKDC0.22247985
96NLK0.19257277
97INSRR0.19254716
98CDK20.17786957
99PAK30.16577197
100MAP2K60.16222611

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.70604154
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.55657238
3Protein export_Homo sapiens_hsa030603.52220367
4Ribosome_Homo sapiens_hsa030103.05932405
5Oxidative phosphorylation_Homo sapiens_hsa001903.04840590
6RNA polymerase_Homo sapiens_hsa030203.04450621
7Mismatch repair_Homo sapiens_hsa034302.76112740
8DNA replication_Homo sapiens_hsa030302.66395413
9Parkinsons disease_Homo sapiens_hsa050122.59963302
10Spliceosome_Homo sapiens_hsa030402.30144337
11RNA transport_Homo sapiens_hsa030132.17885584
12Basal transcription factors_Homo sapiens_hsa030222.17180582
13One carbon pool by folate_Homo sapiens_hsa006702.15711068
14RNA degradation_Homo sapiens_hsa030182.08358536
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07988644
16Nucleotide excision repair_Homo sapiens_hsa034202.07611728
17Homologous recombination_Homo sapiens_hsa034401.96227648
18Huntingtons disease_Homo sapiens_hsa050161.86871298
19Non-homologous end-joining_Homo sapiens_hsa034501.85081620
20Base excision repair_Homo sapiens_hsa034101.75849255
21Pyrimidine metabolism_Homo sapiens_hsa002401.64391491
22Vitamin B6 metabolism_Homo sapiens_hsa007501.53204495
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53078153
24Alzheimers disease_Homo sapiens_hsa050101.52004209
25Fanconi anemia pathway_Homo sapiens_hsa034601.44121650
26Propanoate metabolism_Homo sapiens_hsa006401.42586629
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34126634
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32899858
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25324640
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.24631004
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21130995
32Folate biosynthesis_Homo sapiens_hsa007901.20276171
33Purine metabolism_Homo sapiens_hsa002301.17754208
34Asthma_Homo sapiens_hsa053101.12672987
35Pyruvate metabolism_Homo sapiens_hsa006201.12247500
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07631620
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04555395
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90058338
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89643374
40Steroid biosynthesis_Homo sapiens_hsa001000.87933611
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86893673
42Caffeine metabolism_Homo sapiens_hsa002320.86742755
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86629120
44Systemic lupus erythematosus_Homo sapiens_hsa053220.84899612
45mRNA surveillance pathway_Homo sapiens_hsa030150.83550549
46Cell cycle_Homo sapiens_hsa041100.83352449
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81541879
48Sulfur metabolism_Homo sapiens_hsa009200.79979496
49Sulfur relay system_Homo sapiens_hsa041220.79845954
50Allograft rejection_Homo sapiens_hsa053300.77229185
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.76259218
52Cardiac muscle contraction_Homo sapiens_hsa042600.74245680
53Carbon metabolism_Homo sapiens_hsa012000.73846622
54Epstein-Barr virus infection_Homo sapiens_hsa051690.67392598
55Primary immunodeficiency_Homo sapiens_hsa053400.65737502
56Biosynthesis of amino acids_Homo sapiens_hsa012300.65122309
57Metabolic pathways_Homo sapiens_hsa011000.63114609
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62034338
59Autoimmune thyroid disease_Homo sapiens_hsa053200.61922483
60Selenocompound metabolism_Homo sapiens_hsa004500.61457278
61Glutathione metabolism_Homo sapiens_hsa004800.61082812
62Collecting duct acid secretion_Homo sapiens_hsa049660.58756456
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58486736
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58117351
65Peroxisome_Homo sapiens_hsa041460.57157663
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57086357
67Butanoate metabolism_Homo sapiens_hsa006500.56389441
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55876584
69Phototransduction_Homo sapiens_hsa047440.50251570
70Type I diabetes mellitus_Homo sapiens_hsa049400.48390216
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46074700
72Vitamin digestion and absorption_Homo sapiens_hsa049770.44538466
73N-Glycan biosynthesis_Homo sapiens_hsa005100.43897140
74beta-Alanine metabolism_Homo sapiens_hsa004100.41908941
75Tryptophan metabolism_Homo sapiens_hsa003800.41710255
76p53 signaling pathway_Homo sapiens_hsa041150.41351479
77Fatty acid degradation_Homo sapiens_hsa000710.41286213
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40532737
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.40502242
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.35662509
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35334865
82Arginine and proline metabolism_Homo sapiens_hsa003300.34161966
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34085250
84Oocyte meiosis_Homo sapiens_hsa041140.32949413
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.31384671
86Linoleic acid metabolism_Homo sapiens_hsa005910.30255146
87Fatty acid elongation_Homo sapiens_hsa000620.29185064
88Rheumatoid arthritis_Homo sapiens_hsa053230.28094611
89Regulation of autophagy_Homo sapiens_hsa041400.27151635
90Vibrio cholerae infection_Homo sapiens_hsa051100.25285244
91Alcoholism_Homo sapiens_hsa050340.22970017
92Measles_Homo sapiens_hsa051620.21416150
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18819346
94Antigen processing and presentation_Homo sapiens_hsa046120.18532067
95Fatty acid metabolism_Homo sapiens_hsa012120.18031858
96Hematopoietic cell lineage_Homo sapiens_hsa046400.16882924
97Pentose phosphate pathway_Homo sapiens_hsa000300.15579074
98Nitrogen metabolism_Homo sapiens_hsa009100.14999017
99Chemical carcinogenesis_Homo sapiens_hsa052040.13540631
100Retinol metabolism_Homo sapiens_hsa008300.12619888

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »