ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of triglyceride catabolic process (GO:0010896)	8.76590388
2	high-density lipoprotein particle remodeling (GO:0034375)	7.79394603
3	phospholipid efflux (GO:0033700)	6.90800510
4	reverse cholesterol transport (GO:0043691)	6.52800337
5	plasma lipoprotein particle assembly (GO:0034377)	5.47814414
6	very-low-density lipoprotein particle assembly (GO:0034379)	5.20460020
7	regulation of cholesterol esterification (GO:0010872)	4.96847809
8	DNA damage response, detection of DNA damage (GO:0042769)	4.85511524
9	proteasome assembly (GO:0043248)	4.78409048
10	protein-lipid complex assembly (GO:0065005)	4.72888522
11	plasma lipoprotein particle remodeling (GO:0034369)	4.70412624
12	protein-lipid complex remodeling (GO:0034368)	4.70412624
13	macromolecular complex remodeling (GO:0034367)	4.70412624
14	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.66171445
15	cholesterol efflux (GO:0033344)	4.32396555
16	cullin deneddylation (GO:0010388)	4.24662525
17	regulation of immunoglobulin secretion (GO:0051023)	3.98100300
18	maturation of 5.8S rRNA (GO:0000460)	3.90445252
19	negative regulation of lipase activity (GO:0060192)	3.79183370
20	protein deneddylation (GO:0000338)	3.76203591
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.75793718
22	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.75205913
23	plasma lipoprotein particle clearance (GO:0034381)	3.59990394
24	rRNA catabolic process (GO:0016075)	3.57353628
25	regulation of triglyceride metabolic process (GO:0090207)	3.55243530
26	negative regulation of sterol transport (GO:0032372)	3.46566018
27	negative regulation of cholesterol transport (GO:0032375)	3.46566018
28	cellular response to oxygen radical (GO:0071450)	3.46467126
29	removal of superoxide radicals (GO:0019430)	3.46467126
30	cellular response to superoxide (GO:0071451)	3.46467126
31	regulation of lipoprotein particle clearance (GO:0010984)	3.45809149
32	synapsis (GO:0007129)	3.39977339
33	plasma lipoprotein particle organization (GO:0071827)	3.37672194
34	transepithelial transport (GO:0070633)	3.33927958
35	ribosome assembly (GO:0042255)	3.33208252
36	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.29628832
37	regulation of lipoprotein metabolic process (GO:0050746)	3.28311775
38	positive regulation of lipoprotein lipase activity (GO:0051006)	3.23312568
39	positive regulation of triglyceride lipase activity (GO:0061365)	3.23312568
40	regulation of isotype switching to IgG isotypes (GO:0048302)	3.18674399
41	neutral lipid catabolic process (GO:0046461)	3.13505043
42	acylglycerol catabolic process (GO:0046464)	3.13505043
43	triglyceride catabolic process (GO:0019433)	3.11437287
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.10646041
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.10255933
46	protein-lipid complex subunit organization (GO:0071825)	3.09539418
47	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.07822978
48	protein K63-linked deubiquitination (GO:0070536)	3.07707363
49	mitochondrial RNA metabolic process (GO:0000959)	3.07251023
50	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.06574474
51	regulation of mitotic spindle checkpoint (GO:1903504)	3.06574474
52	lipoprotein transport (GO:0042953)	3.03525358
53	ovulation from ovarian follicle (GO:0001542)	3.02202058
54	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.99438542
55	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.99055186
56	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.98056724
57	mitochondrial respiratory chain complex assembly (GO:0033108)	2.97349877
58	regulation of cellular amino acid metabolic process (GO:0006521)	2.96573066
59	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.96178438
60	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.96178438
61	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.96178438
62	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.95400253
63	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.95400253
64	transcription from mitochondrial promoter (GO:0006390)	2.91724653
65	mannosylation (GO:0097502)	2.90532944
66	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.88757007
67	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.88757007
68	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.87366955
69	rRNA methylation (GO:0031167)	2.87365885
70	GDP-mannose metabolic process (GO:0019673)	2.86601270
71	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.85163347
72	DNA deamination (GO:0045006)	2.84034916
73	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.83821117
74	rRNA modification (GO:0000154)	2.83329904
75	protein refolding (GO:0042026)	2.81811439
76	protein complex biogenesis (GO:0070271)	2.80123541
77	tRNA aminoacylation for protein translation (GO:0006418)	2.80121287
78	cellular response to zinc ion (GO:0071294)	2.79600243
79	positive regulation of triglyceride metabolic process (GO:0090208)	2.76614306
80	positive regulation of growth hormone secretion (GO:0060124)	2.76529385
81	acylglycerol homeostasis (GO:0055090)	2.75956860
82	triglyceride homeostasis (GO:0070328)	2.75956860
83	ribosomal large subunit biogenesis (GO:0042273)	2.75575875
84	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.74916398
85	amino acid activation (GO:0043038)	2.74656717
86	tRNA aminoacylation (GO:0043039)	2.74656717
87	ribonucleoprotein complex disassembly (GO:0032988)	2.74524590
88	rRNA processing (GO:0006364)	2.74148646
89	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.73190848
90	cellular response to arsenic-containing substance (GO:0071243)	2.72165700
91	negative regulation of ligase activity (GO:0051352)	2.71855080
92	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.71855080
93	glutathione derivative metabolic process (GO:1901685)	2.69775171
94	glutathione derivative biosynthetic process (GO:1901687)	2.69775171
95	protein neddylation (GO:0045116)	2.69161386
96	cellular response to ATP (GO:0071318)	2.69102373
97	glial cell proliferation (GO:0014009)	2.68406395
98	rRNA metabolic process (GO:0016072)	2.67515642
99	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.66484538
100	protein carboxylation (GO:0018214)	2.65161348

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.09883955
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.62939777
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.74847109
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.47576832
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.98823398
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.96581589
7	VDR_23849224_ChIP-Seq_CD4+_Human	2.90749084
8	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.88907571
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.85971174
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.83958767
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.83315152
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.80467389
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.72684055
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.62794367
15	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.58052689
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.50239207
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.48313969
18	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.38887381
19	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.37985572
20	GATA1_22025678_ChIP-Seq_K562_Human	2.33159179
21	DCP1A_22483619_ChIP-Seq_HELA_Human	2.23407503
22	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.15875515
23	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.13446630
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11542483
25	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.09813112
26	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.00879535
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.97148139
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.91029959
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.87366516
30	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.85659072
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.79267631
32	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.73937702
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.73872319
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.73819852
35	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.73410546
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.70987643
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66744171
38	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.61000274
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58978740
40	VDR_22108803_ChIP-Seq_LS180_Human	1.58648921
41	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.56807483
42	E2F7_22180533_ChIP-Seq_HELA_Human	1.55805386
43	ZNF274_21170338_ChIP-Seq_K562_Hela	1.55297971
44	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.51903923
45	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.51875872
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.49774281
47	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.48064014
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47258253
49	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.38911265
50	EWS_26573619_Chip-Seq_HEK293_Human	1.38192386
51	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.37796839
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35444908
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35444908
54	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.34051023
55	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.33478564
56	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.33008462
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32318600
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31106337
59	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.28292288
60	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.27801083
61	XRN2_22483619_ChIP-Seq_HELA_Human	1.26522051
62	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.25130036
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.24948500
64	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.24554145
65	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.23804797
66	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.23770915
67	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.15803076
68	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.11891021
69	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.06334443
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.03992548
71	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.03123275
72	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.02759704
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00527014
74	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.98339741
75	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.97942039
76	GATA3_26560356_Chip-Seq_TH1_Human	0.96938076
77	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.96553095
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.95361236
79	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92184015
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91652137
81	ERG_20517297_ChIP-Seq_VCAP_Human	0.90978573
82	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.90886268
83	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.90767356
84	P300_18555785_Chip-Seq_ESCs_Mouse	0.89931976
85	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.89787449
86	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.88637715
87	RBPJ_21746931_ChIP-Seq_IB4_Human	0.88479120
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87843622
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86693697
90	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.85832948
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.85520606
92	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.85125318
93	AR_20517297_ChIP-Seq_VCAP_Human	0.84258191
94	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.82470216
95	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.81521372
96	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.81033680
97	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.80953062
98	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.80818664
99	GATA3_26560356_Chip-Seq_TH2_Human	0.80143347
100	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.79792056

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009840_abnormal_foam_cell	8.63353438
2	MP0005360_urolithiasis	5.43859102
3	MP0004270_analgesia	2.93291667
4	MP0008877_abnormal_DNA_methylation	2.78120821
5	MP0003718_maternal_effect	2.45782931
6	MP0006072_abnormal_retinal_apoptosis	2.37529257
7	MP0003878_abnormal_ear_physiology	2.36037381
8	MP0005377_hearing/vestibular/ear_phenot	2.36037381
9	MP0008875_abnormal_xenobiotic_pharmacok	2.27030517
10	MP0004145_abnormal_muscle_electrophysio	2.24233925
11	MP0003693_abnormal_embryo_hatching	2.20056896
12	MP0008058_abnormal_DNA_repair	2.13285225
13	MP0004142_abnormal_muscle_tone	2.11524335
14	MP0005645_abnormal_hypothalamus_physiol	1.96454008
15	MP0001835_abnormal_antigen_presentation	1.94701497
16	MP0010329_abnormal_lipoprotein_level	1.93658864
17	MP0005551_abnormal_eye_electrophysiolog	1.89929847
18	MP0005332_abnormal_amino_acid	1.87812555
19	MP0010094_abnormal_chromosome_stability	1.85663148
20	MP0003186_abnormal_redox_activity	1.84222600
21	MP0002876_abnormal_thyroid_physiology	1.80784195
22	MP0005671_abnormal_response_to	1.69510673
23	MP0009333_abnormal_splenocyte_physiolog	1.62628117
24	MP0001919_abnormal_reproductive_system	1.62259867
25	MP0000372_irregular_coat_pigmentation	1.60846628
26	MP0005389_reproductive_system_phenotype	1.53103942
27	MP0002638_abnormal_pupillary_reflex	1.52953901
28	MP0004147_increased_porphyrin_level	1.51345805
29	MP0005084_abnormal_gallbladder_morpholo	1.48318555
30	MP0006036_abnormal_mitochondrial_physio	1.46637376
31	MP0008872_abnormal_physiological_respon	1.46190571
32	MP0003300_gastrointestinal_ulcer	1.44562399
33	MP0001529_abnormal_vocalization	1.43570087
34	MP0004957_abnormal_blastocyst_morpholog	1.43185977
35	MP0004019_abnormal_vitamin_homeostasis	1.40029759
36	MP0002163_abnormal_gland_morphology	1.34512514
37	MP0001502_abnormal_circadian_rhythm	1.34266673
38	MP0003786_premature_aging	1.34199231
39	MP0006035_abnormal_mitochondrial_morpho	1.23028085
40	MP0005379_endocrine/exocrine_gland_phen	1.21090762
41	MP0009643_abnormal_urine_homeostasis	1.16496441
42	MP0005636_abnormal_mineral_homeostasis	1.15123741
43	MP0000465_gastrointestinal_hemorrhage	1.14705906
44	MP0002102_abnormal_ear_morphology	1.13068860
45	MP0002160_abnormal_reproductive_system	1.11386056
46	MP0004782_abnormal_surfactant_physiolog	1.11335174
47	MP0001666_abnormal_nutrient_absorption	1.07433953
48	MP0002090_abnormal_vision	1.00240903
49	MP0001905_abnormal_dopamine_level	0.96701717
50	MP0002210_abnormal_sex_determination	0.96601671
51	MP0001790_abnormal_immune_system	0.96552821
52	MP0005387_immune_system_phenotype	0.96552821
53	MP0002139_abnormal_hepatobiliary_system	0.96221095
54	MP0002166_altered_tumor_susceptibility	0.93824406
55	MP0008995_early_reproductive_senescence	0.93338681
56	MP0008057_abnormal_DNA_replication	0.92701928
57	MP0003806_abnormal_nucleotide_metabolis	0.91030982
58	MP0005365_abnormal_bile_salt	0.89223670
59	MP0001873_stomach_inflammation	0.88795119
60	MP0002006_tumorigenesis	0.88294745
61	MP0005085_abnormal_gallbladder_physiolo	0.87637215
62	MP0003045_fibrosis	0.87583449
63	MP0000653_abnormal_sex_gland	0.87397204
64	MP0003195_calcinosis	0.86891930
65	MP0002734_abnormal_mechanical_nocicepti	0.85782196
66	MP0000685_abnormal_immune_system	0.85770464
67	MP0000604_amyloidosis	0.85516700
68	MP0001348_abnormal_lacrimal_gland	0.85236186
69	MP0005395_other_phenotype	0.85197043
70	MP0001293_anophthalmia	0.84271230
71	MP0002693_abnormal_pancreas_physiology	0.83934663
72	MP0004043_abnormal_pH_regulation	0.82976144
73	MP0001800_abnormal_humoral_immune	0.81788737
74	MP0003077_abnormal_cell_cycle	0.81608106
75	MP0001929_abnormal_gametogenesis	0.80973504
76	MP0003567_abnormal_fetal_cardiomyocyte	0.79139266
77	MP0001119_abnormal_female_reproductive	0.78572894
78	MP0005253_abnormal_eye_physiology	0.75850351
79	MP0001853_heart_inflammation	0.74382895
80	MP0001485_abnormal_pinna_reflex	0.73898142
81	MP0005584_abnormal_enzyme/coenzyme_acti	0.71826208
82	MP0002254_reproductive_system_inflammat	0.70821861
83	MP0001145_abnormal_male_reproductive	0.66732258
84	MP0002272_abnormal_nervous_system	0.64633586
85	MP0003646_muscle_fatigue	0.64093667
86	MP0005410_abnormal_fertilization	0.64038765
87	MP0008007_abnormal_cellular_replicative	0.63507241
88	MP0001984_abnormal_olfaction	0.63052837
89	MP0002138_abnormal_hepatobiliary_system	0.61990550
90	MP0005167_abnormal_blood-brain_barrier	0.60119502
91	MP0002148_abnormal_hypersensitivity_rea	0.59767043
92	MP0001177_atelectasis	0.58765377
93	MP0009046_muscle_twitch	0.58358462
94	MP0010155_abnormal_intestine_physiology	0.58008325
95	MP0002837_dystrophic_cardiac_calcinosis	0.56285752
96	MP0003111_abnormal_nucleus_morphology	0.56166315
97	MP0004215_abnormal_myocardial_fiber	0.55476165
98	MP0005394_taste/olfaction_phenotype	0.54787043
99	MP0005499_abnormal_olfactory_system	0.54787043
100	MP0002751_abnormal_autonomic_nervous	0.53957740

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypobetalipoproteinemia (HP:0003563)	7.12759924
2	Hyperlipoproteinemia (HP:0010980)	4.25802845
3	Hypolipoproteinemia (HP:0010981)	3.92166770
4	Acute necrotizing encephalopathy (HP:0006965)	3.80252578
5	Acute encephalopathy (HP:0006846)	3.80224328
6	Hyperglycinemia (HP:0002154)	3.56364019
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.55509041
8	Increased CSF lactate (HP:0002490)	3.41166215
9	Mitochondrial inheritance (HP:0001427)	3.40133212
10	Pigmentary retinal degeneration (HP:0001146)	3.32059750
11	Hypomagnesemia (HP:0002917)	3.30225624
12	Hepatocellular necrosis (HP:0001404)	3.29668938
13	Abnormality of pyrimidine metabolism (HP:0004353)	3.27659491
14	Type I transferrin isoform profile (HP:0003642)	3.27480861
15	Malnutrition (HP:0004395)	3.25873573
16	Progressive macrocephaly (HP:0004481)	3.22593226
17	Lipid accumulation in hepatocytes (HP:0006561)	3.20058997
18	Hepatic necrosis (HP:0002605)	3.12548502
19	Increased hepatocellular lipid droplets (HP:0006565)	3.10847869
20	Dyschromatopsia (HP:0007641)	3.05383088
21	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.04463242
22	Hypoplasia of the pons (HP:0012110)	3.00528462
23	Tetany (HP:0001281)	2.96725151
24	Abnormality of DNA repair (HP:0003254)	2.91207359
25	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.90350540
26	Abnormality of the pons (HP:0007361)	2.85092703
27	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.81491305
28	Abnormality of alanine metabolism (HP:0010916)	2.81491305
29	Hyperalaninemia (HP:0003348)	2.81491305
30	Stomatitis (HP:0010280)	2.80691316
31	Cerebral edema (HP:0002181)	2.80000894
32	Methylmalonic aciduria (HP:0012120)	2.78215213
33	Methylmalonic acidemia (HP:0002912)	2.74726109
34	Hypoproteinemia (HP:0003075)	2.72993378
35	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.72236138
36	Type 2 muscle fiber atrophy (HP:0003554)	2.63846033
37	Nausea (HP:0002018)	2.61406985
38	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.57356405
39	Abnormal protein N-linked glycosylation (HP:0012347)	2.57356405
40	Abnormal protein glycosylation (HP:0012346)	2.57356405
41	Abnormal glycosylation (HP:0012345)	2.57356405
42	Pendular nystagmus (HP:0012043)	2.55003301
43	Abnormality of magnesium homeostasis (HP:0004921)	2.53374902
44	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.53167655
45	Reduced antithrombin III activity (HP:0001976)	2.49892329
46	Muscle fiber atrophy (HP:0100295)	2.45411980
47	IgG deficiency (HP:0004315)	2.45181834
48	Abnormality of methionine metabolism (HP:0010901)	2.45077983
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.42639307
50	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.41059844
51	Hypoplasia of the fovea (HP:0007750)	2.41059844
52	3-Methylglutaconic aciduria (HP:0003535)	2.40587300
53	Arthropathy (HP:0003040)	2.40565153
54	Optic disc pallor (HP:0000543)	2.40035007
55	Increased serum lactate (HP:0002151)	2.39641778
56	Duplicated collecting system (HP:0000081)	2.38121587
57	Degeneration of anterior horn cells (HP:0002398)	2.35885386
58	Abnormality of the anterior horn cell (HP:0006802)	2.35885386
59	Increased intramyocellular lipid droplets (HP:0012240)	2.34199857
60	Prolonged partial thromboplastin time (HP:0003645)	2.28986450
61	Bicornuate uterus (HP:0000813)	2.28733106
62	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.27769952
63	Abnormality of the renal collecting system (HP:0004742)	2.26207743
64	Exercise intolerance (HP:0003546)	2.21751534
65	Abnormality of serum amino acid levels (HP:0003112)	2.20552117
66	Renal Fanconi syndrome (HP:0001994)	2.18939260
67	Abnormality of glycolysis (HP:0004366)	2.17893868
68	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.16552697
69	Abnormality of vitamin B metabolism (HP:0004340)	2.14837530
70	Increased serum pyruvate (HP:0003542)	2.12057616
71	Chromsome breakage (HP:0040012)	2.11214137
72	Lactic acidosis (HP:0003128)	2.10027769
73	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.10006028
74	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.10006028
75	Increased muscle lipid content (HP:0009058)	2.08683698
76	Opisthotonus (HP:0002179)	2.06831550
77	Metabolic acidosis (HP:0001942)	2.05594235
78	Leukodystrophy (HP:0002415)	2.04739452
79	CNS demyelination (HP:0007305)	2.03346825
80	Neonatal respiratory distress (HP:0002643)	2.02513842
81	Meckel diverticulum (HP:0002245)	2.02256458
82	Testicular atrophy (HP:0000029)	2.01833371
83	Abolished electroretinogram (ERG) (HP:0000550)	2.01228567
84	Abnormality of glycine metabolism (HP:0010895)	2.00562605
85	Abnormality of serine family amino acid metabolism (HP:0010894)	2.00562605
86	Dicarboxylic aciduria (HP:0003215)	1.99060779
87	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.99060779
88	Abnormality of the ileum (HP:0001549)	1.98469401
89	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.97897683
90	Poor head control (HP:0002421)	1.97680729
91	Lethargy (HP:0001254)	1.94211663
92	Abnormality of the fovea (HP:0000493)	1.94186326
93	Horizontal nystagmus (HP:0000666)	1.92759072
94	Respiratory failure (HP:0002878)	1.91444255
95	Vacuolated lymphocytes (HP:0001922)	1.90295464
96	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.88435819
97	Abnormality of the preputium (HP:0100587)	1.87983125
98	Hyperglycinuria (HP:0003108)	1.86950149
99	Abnormality of midbrain morphology (HP:0002418)	1.86698031
100	Molar tooth sign on MRI (HP:0002419)	1.86698031

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIK3CG	5.79444418
2	MUSK	5.51945676
3	TSSK6	3.64690596
4	TLK1	3.34019475
5	ZAK	3.27491913
6	MST4	3.18818715
7	BUB1	2.88393577
8	PBK	2.62245867
9	NUAK1	2.54109536
10	NEK1	2.34255321
11	BCKDK	2.00941512
12	TESK2	1.92195214
13	NME1	1.65825070
14	FRK	1.62521210
15	EIF2AK3	1.57127736
16	SRPK1	1.49996516
17	WNK3	1.41091586
18	PIM2	1.34463665
19	VRK1	1.33709607
20	EIF2AK1	1.31663699
21	VRK2	1.26659953
22	NEK9	1.21128970
23	TXK	1.18352721
24	STK16	1.14974033
25	TAOK3	1.12110608
26	PDK2	1.10592090
27	MAP3K12	1.10176419
28	MKNK1	1.09947993
29	GRK1	1.07220196
30	ADRBK2	1.05157554
31	PLK3	1.02326940
32	PAK4	0.99546521
33	RPS6KA5	0.97472351
34	PINK1	0.94611005
35	TAF1	0.94414653
36	IKBKB	0.92193685
37	PASK	0.86246332
38	CDC7	0.84470373
39	CDK12	0.84302799
40	BCR	0.83152624
41	CSNK1A1L	0.82073654
42	CSNK1G3	0.80158960
43	ACVR1B	0.77864519
44	CSNK1G2	0.77771275
45	GRK5	0.76896148
46	ERBB3	0.73910564
47	MKNK2	0.72927383
48	EIF2AK2	0.72565264
49	WEE1	0.70860730
50	PIM1	0.69745660
51	PLK2	0.67545726
52	AKT2	0.65055035
53	AURKB	0.64968067
54	TRIM28	0.64829714
55	GRK7	0.62436076
56	BMPR1B	0.62198892
57	MARK3	0.60156256
58	ATR	0.58933629
59	IKBKE	0.57556005
60	ALK	0.56870196
61	PLK1	0.56551231
62	OXSR1	0.56032726
63	CSNK1G1	0.55747175
64	DYRK2	0.55109080
65	TNIK	0.53712367
66	TEC	0.52931212
67	DAPK3	0.51223852
68	PRKCE	0.49906206
69	TTK	0.46627225
70	PRKG2	0.46045483
71	CDK19	0.45614209
72	LMTK2	0.44393430
73	BRD4	0.43466723
74	CSNK2A2	0.43392264
75	PTK2B	0.41939760
76	ITK	0.41730431
77	MYLK	0.41326570
78	FGFR1	0.39877574
79	PRKCG	0.39246930
80	DAPK1	0.38739051
81	CSNK2A1	0.38668029
82	CDK6	0.36780981
83	MAP2K6	0.35723436
84	MATK	0.32637643
85	STK38L	0.31997540
86	CHUK	0.31658288
87	MAP4K2	0.29860983
88	STK4	0.29810105
89	STK39	0.29606963
90	AURKA	0.29522510
91	CHEK1	0.29204886
92	CSNK1D	0.28499889
93	MAP3K14	0.27996088
94	SIK3	0.27245630
95	PRKCI	0.27182829
96	FGFR2	0.27170163
97	PRKACB	0.26787401
98	PLK4	0.26035706
99	MAPK13	0.25177568
100	TIE1	0.24814102

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.16236675
2	Protein export_Homo sapiens_hsa03060	4.15642689
3	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.42537864
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.82613978
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.77663324
6	Parkinsons disease_Homo sapiens_hsa05012	2.24557739
7	Asthma_Homo sapiens_hsa05310	2.14605871
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.03030435
9	RNA degradation_Homo sapiens_hsa03018	1.98953194
10	RNA polymerase_Homo sapiens_hsa03020	1.84740552
11	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.84091691
12	Basal transcription factors_Homo sapiens_hsa03022	1.79988315
13	Spliceosome_Homo sapiens_hsa03040	1.79961288
14	Non-homologous end-joining_Homo sapiens_hsa03450	1.77041908
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.75220521
16	RNA transport_Homo sapiens_hsa03013	1.73376629
17	One carbon pool by folate_Homo sapiens_hsa00670	1.68100329
18	Allograft rejection_Homo sapiens_hsa05330	1.66943618
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.66395092
20	Galactose metabolism_Homo sapiens_hsa00052	1.63464666
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.63322255
22	Mineral absorption_Homo sapiens_hsa04978	1.59074259
23	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.57207299
24	Huntingtons disease_Homo sapiens_hsa05016	1.53177637
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.52816464
26	Fat digestion and absorption_Homo sapiens_hsa04975	1.52187271
27	Propanoate metabolism_Homo sapiens_hsa00640	1.49357785
28	DNA replication_Homo sapiens_hsa03030	1.46881523
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.46310017
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.44734246
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.39758954
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36389182
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26440112
34	Alzheimers disease_Homo sapiens_hsa05010	1.25502895
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.14721368
36	Glutathione metabolism_Homo sapiens_hsa00480	1.13744344
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13187602
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10713787
39	Mismatch repair_Homo sapiens_hsa03430	1.06944038
40	Ribosome_Homo sapiens_hsa03010	1.05848176
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00165438
42	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.99114578
43	Purine metabolism_Homo sapiens_hsa00230	0.98444538
44	Folate biosynthesis_Homo sapiens_hsa00790	0.96025661
45	Graft-versus-host disease_Homo sapiens_hsa05332	0.95773899
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94353551
47	Fatty acid elongation_Homo sapiens_hsa00062	0.91205678
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90919561
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.87604505
50	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.83430173
51	Homologous recombination_Homo sapiens_hsa03440	0.83401188
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.82645870
53	Base excision repair_Homo sapiens_hsa03410	0.82323350
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.82091625
55	Butanoate metabolism_Homo sapiens_hsa00650	0.80933479
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.80796378
57	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.80634535
58	Phototransduction_Homo sapiens_hsa04744	0.79972007
59	Pyruvate metabolism_Homo sapiens_hsa00620	0.78719737
60	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.77751258
61	Carbon metabolism_Homo sapiens_hsa01200	0.77472786
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.75028699
63	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.74915112
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74546076
65	Sulfur metabolism_Homo sapiens_hsa00920	0.74184490
66	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.73673347
67	Antigen processing and presentation_Homo sapiens_hsa04612	0.73062706
68	Alcoholism_Homo sapiens_hsa05034	0.71801505
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71538021
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.71103524
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71021825
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70412178
73	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.67424559
74	Regulation of autophagy_Homo sapiens_hsa04140	0.67353380
75	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.65402796
76	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.63547003
77	Metabolic pathways_Homo sapiens_hsa01100	0.63467546
78	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62699381
79	Fanconi anemia pathway_Homo sapiens_hsa03460	0.62479705
80	Vibrio cholerae infection_Homo sapiens_hsa05110	0.61311049
81	Primary immunodeficiency_Homo sapiens_hsa05340	0.57689265
82	Circadian rhythm_Homo sapiens_hsa04710	0.57440969
83	mRNA surveillance pathway_Homo sapiens_hsa03015	0.55007267
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53001624
85	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52784165
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.52519755
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52425148
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.50656497
89	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.50195134
90	Fatty acid degradation_Homo sapiens_hsa00071	0.47403701
91	Retinol metabolism_Homo sapiens_hsa00830	0.47057317
92	Caffeine metabolism_Homo sapiens_hsa00232	0.44073490
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42169581
94	Arginine biosynthesis_Homo sapiens_hsa00220	0.41608990
95	Pentose phosphate pathway_Homo sapiens_hsa00030	0.41473282
96	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.40663915
97	Legionellosis_Homo sapiens_hsa05134	0.37637054
98	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.37134898
99	Peroxisome_Homo sapiens_hsa04146	0.36794916
100	Sphingolipid metabolism_Homo sapiens_hsa00600	0.35691186

HSPD1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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