HSPD1P16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adaptation of signaling pathway (GO:0023058)8.96252277
2tachykinin receptor signaling pathway (GO:0007217)7.84225820
3positive regulation of uterine smooth muscle contraction (GO:0070474)6.27631795
4establishment of protein localization to mitochondrial membrane (GO:0090151)6.06576245
5neuron fate determination (GO:0048664)5.86272289
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.47515440
7viral transcription (GO:0019083)5.19085705
8chaperone-mediated protein complex assembly (GO:0051131)5.09310562
9translational termination (GO:0006415)4.98755152
10ATP synthesis coupled proton transport (GO:0015986)4.80734598
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.80734598
12serotonin metabolic process (GO:0042428)4.76984761
13regulation of uterine smooth muscle contraction (GO:0070472)4.65234325
14dopamine biosynthetic process (GO:0042416)4.63689366
15regulation of dopamine metabolic process (GO:0042053)4.48933391
16regulation of catecholamine metabolic process (GO:0042069)4.48933391
17cotranslational protein targeting to membrane (GO:0006613)4.39668480
18protein targeting to ER (GO:0045047)4.36507848
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.33995252
20translational elongation (GO:0006414)4.26323067
21hyperosmotic salinity response (GO:0042538)4.24805319
22neuron fate specification (GO:0048665)4.20564868
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.16980886
24RNA destabilization (GO:0050779)4.15695602
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.09724954
26spinal cord association neuron differentiation (GO:0021527)4.03988655
27primary amino compound metabolic process (GO:1901160)4.00326930
28protein localization to endoplasmic reticulum (GO:0070972)3.99479707
29otic vesicle formation (GO:0030916)3.97892234
30positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.76680519
31regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.76680519
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.74721580
33regulation of feeding behavior (GO:0060259)3.71801599
34cellular protein complex disassembly (GO:0043624)3.68631053
35response to insecticide (GO:0017085)3.61201735
36alkaloid metabolic process (GO:0009820)3.55949070
37viral life cycle (GO:0019058)3.54170517
38behavioral response to nicotine (GO:0035095)3.53603423
39activation of MAPKKK activity (GO:0000185)3.52163176
40translational initiation (GO:0006413)3.45594369
41positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.44061210
42regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.44061210
43rRNA modification (GO:0000154)3.42538504
44catecholamine biosynthetic process (GO:0042423)3.41851837
45catechol-containing compound biosynthetic process (GO:0009713)3.41851837
46chaperone-mediated protein transport (GO:0072321)3.40183077
47ribosomal small subunit assembly (GO:0000028)3.39008760
48positive regulation of dendritic spine development (GO:0060999)3.37879080
49positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.35106644
50positive regulation of cell cycle G2/M phase transition (GO:1902751)3.35106644
51nonmotile primary cilium assembly (GO:0035058)3.34500753
52multicellular organismal aging (GO:0010259)3.30358572
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26208985
54startle response (GO:0001964)3.25765951
55negative regulation by host of viral transcription (GO:0043922)3.24723949
56signal peptide processing (GO:0006465)3.24585354
57forebrain neuron differentiation (GO:0021879)3.23360025
58positive regulation of dendritic spine morphogenesis (GO:0061003)3.17070203
59protein complex disassembly (GO:0043241)3.13636794
60rRNA methylation (GO:0031167)3.11209095
61synaptic transmission, cholinergic (GO:0007271)3.10402947
62respiratory electron transport chain (GO:0022904)3.09508616
63electron transport chain (GO:0022900)3.02739038
64hindbrain development (GO:0030902)3.02195295
65proximal/distal pattern formation (GO:0009954)2.98952698
66positive regulation of response to oxidative stress (GO:1902884)2.98658205
67positive regulation of cellular response to oxidative stress (GO:1900409)2.98658205
68limb bud formation (GO:0060174)2.97283390
69water-soluble vitamin biosynthetic process (GO:0042364)2.96978875
70maturation of SSU-rRNA (GO:0030490)2.96888980
71response to auditory stimulus (GO:0010996)2.96138661
72regulation of meiosis I (GO:0060631)2.90445153
73lateral sprouting from an epithelium (GO:0060601)2.87098699
74indole-containing compound metabolic process (GO:0042430)2.86878199
75macromolecular complex disassembly (GO:0032984)2.86450289
76indolalkylamine metabolic process (GO:0006586)2.86227868
77establishment of nucleus localization (GO:0040023)2.83027256
78cochlea development (GO:0090102)2.82507845
79positive regulation of mRNA catabolic process (GO:0061014)2.81804323
80ribosomal small subunit biogenesis (GO:0042274)2.81142288
81protein targeting to membrane (GO:0006612)2.78635556
82nuclear-transcribed mRNA catabolic process (GO:0000956)2.76839759
83DNA damage response, detection of DNA damage (GO:0042769)2.76574861
84neuronal action potential propagation (GO:0019227)2.74035068
85central nervous system projection neuron axonogenesis (GO:0021952)2.69655161
86sulfation (GO:0051923)2.68036532
87purine nucleobase biosynthetic process (GO:0009113)2.67245445
88forebrain neuron development (GO:0021884)2.64796584
89dopamine transport (GO:0015872)2.64762532
90mRNA catabolic process (GO:0006402)2.64171901
91cell differentiation in spinal cord (GO:0021515)2.63572366
92glutamate receptor signaling pathway (GO:0007215)2.63468421
93retinal ganglion cell axon guidance (GO:0031290)2.61516829
94regulation of mRNA catabolic process (GO:0061013)2.58677728
95ATP biosynthetic process (GO:0006754)2.58136987
96regulation of nuclear cell cycle DNA replication (GO:0033262)2.57467537
97negative regulation of inclusion body assembly (GO:0090084)2.57122535
98neuronal action potential (GO:0019228)2.56815925
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55817970
100intracellular protein transmembrane import (GO:0044743)2.54003549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.88482592
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.78409272
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.60212694
4TAF15_26573619_Chip-Seq_HEK293_Human3.32697440
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.26721621
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.05352047
7CBX2_27304074_Chip-Seq_ESCs_Mouse3.04553095
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.69143741
9GBX2_23144817_ChIP-Seq_PC3_Human2.68499710
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.50705797
11FUS_26573619_Chip-Seq_HEK293_Human2.41163641
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39971315
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.37667815
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.25726098
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.20028109
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14163921
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.10440819
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03362713
19VDR_22108803_ChIP-Seq_LS180_Human2.01876736
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93967526
21EWS_26573619_Chip-Seq_HEK293_Human1.91924024
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.91149526
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90346503
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89871379
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87837655
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.85791010
27ZNF274_21170338_ChIP-Seq_K562_Hela1.80376666
28P300_19829295_ChIP-Seq_ESCs_Human1.80143930
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75748391
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73531255
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66520663
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62716703
33REST_21632747_ChIP-Seq_MESCs_Mouse1.62033383
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60395149
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58977516
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55828502
37IGF1R_20145208_ChIP-Seq_DFB_Human1.55172129
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51724657
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51724657
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49624450
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46638549
42ELK1_19687146_ChIP-ChIP_HELA_Human1.44330167
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43324079
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.42266047
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40066259
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.39755071
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38652226
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35148274
49AR_25329375_ChIP-Seq_VCAP_Human1.35139633
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35062124
51KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32519330
52KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32519330
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32519330
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.32462602
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.32315364
56RNF2_27304074_Chip-Seq_NSC_Mouse1.32111647
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30554851
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29971476
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.29461610
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27173241
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26946080
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26806574
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22252038
64CBP_20019798_ChIP-Seq_JUKART_Human1.22252038
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21961627
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21961627
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20831632
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19164164
69SMAD4_21799915_ChIP-Seq_A2780_Human1.19036110
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17902473
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.15415341
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14230102
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13930532
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12497254
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.11721558
76BCAT_22108803_ChIP-Seq_LS180_Human1.11278883
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11152301
78RUNX2_22187159_ChIP-Seq_PCA_Human1.10875805
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07735627
80STAT3_23295773_ChIP-Seq_U87_Human1.07529357
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05890120
82TCF4_22108803_ChIP-Seq_LS180_Human1.05749451
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05694920
84SOX9_26525672_Chip-Seq_HEART_Mouse1.05124725
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04828872
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04509649
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.04240157
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.03391688
89AR_21572438_ChIP-Seq_LNCaP_Human1.00867982
90SOX2_19829295_ChIP-Seq_ESCs_Human0.99859528
91NANOG_19829295_ChIP-Seq_ESCs_Human0.99859528
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99202826
93TBL1_22424771_ChIP-Seq_293T_Human0.97999093
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97091037
95GATA1_26923725_Chip-Seq_HPCs_Mouse0.96016123
96FLI1_21867929_ChIP-Seq_TH2_Mouse0.94039230
97MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92986245
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92413511
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.91539280
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90704082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.39649637
2MP0005423_abnormal_somatic_nervous4.33160471
3MP0002736_abnormal_nociception_after4.01412969
4MP0004147_increased_porphyrin_level3.58232253
5MP0009379_abnormal_foot_pigmentation3.55931537
6MP0001968_abnormal_touch/_nociception3.48944164
7MP0003136_yellow_coat_color3.00332951
8MP0002277_abnormal_respiratory_mucosa2.86775208
9MP0002653_abnormal_ependyma_morphology2.85133943
10MP0005646_abnormal_pituitary_gland2.68115136
11MP0004142_abnormal_muscle_tone2.04463812
12MP0000631_abnormal_neuroendocrine_gland2.01785869
13MP0006292_abnormal_olfactory_placode1.98279699
14MP0001529_abnormal_vocalization1.90668943
15MP0005645_abnormal_hypothalamus_physiol1.90377042
16MP0005084_abnormal_gallbladder_morpholo1.87308538
17MP0004885_abnormal_endolymph1.68819340
18MP0009745_abnormal_behavioral_response1.55728456
19MP0000569_abnormal_digit_pigmentation1.54776055
20MP0002928_abnormal_bile_duct1.53502913
21MP0005187_abnormal_penis_morphology1.52978100
22MP0004145_abnormal_muscle_electrophysio1.43810722
23MP0008058_abnormal_DNA_repair1.43226713
24MP0001486_abnormal_startle_reflex1.42654326
25MP0002735_abnormal_chemical_nociception1.37938936
26MP0002572_abnormal_emotion/affect_behav1.37481389
27MP0003121_genomic_imprinting1.36646281
28MP0001286_abnormal_eye_development1.36433346
29MP0002067_abnormal_sensory_capabilities1.35379206
30MP0004133_heterotaxia1.32914387
31MP0003315_abnormal_perineum_morphology1.31580297
32MP0005171_absent_coat_pigmentation1.29662567
33MP0000026_abnormal_inner_ear1.29507793
34MP0003123_paternal_imprinting1.27480865
35MP0000778_abnormal_nervous_system1.27012978
36MP0003787_abnormal_imprinting1.26583103
37MP0003635_abnormal_synaptic_transmissio1.26432766
38MP0001485_abnormal_pinna_reflex1.26318092
39MP0002272_abnormal_nervous_system1.24901753
40MP0000955_abnormal_spinal_cord1.24454021
41MP0002733_abnormal_thermal_nociception1.24260265
42MP0001440_abnormal_grooming_behavior1.24025879
43MP0006072_abnormal_retinal_apoptosis1.23998097
44MP0009697_abnormal_copulation1.23776564
45MP0003937_abnormal_limbs/digits/tail_de1.23465281
46MP0003938_abnormal_ear_development1.21188994
47MP0000049_abnormal_middle_ear1.19662109
48MP0005410_abnormal_fertilization1.16417189
49MP0001502_abnormal_circadian_rhythm1.14704221
50MP0002938_white_spotting1.14348080
51MP0002638_abnormal_pupillary_reflex1.12651476
52MP0005551_abnormal_eye_electrophysiolog1.12008956
53MP0002184_abnormal_innervation1.11967937
54MP0003943_abnormal_hepatobiliary_system1.11220014
55MP0002734_abnormal_mechanical_nocicepti1.09075787
56MP0002282_abnormal_trachea_morphology1.08129943
57MP0009250_abnormal_appendicular_skeleto1.07112870
58MP0000639_abnormal_adrenal_gland1.07060823
59MP0005503_abnormal_tendon_morphology1.06689794
60MP0002063_abnormal_learning/memory/cond1.03448293
61MP0006276_abnormal_autonomic_nervous1.03440707
62MP0001970_abnormal_pain_threshold1.02100479
63MP0005174_abnormal_tail_pigmentation1.01387972
64MP0001293_anophthalmia1.00637561
65MP0002138_abnormal_hepatobiliary_system0.99453940
66MP0000372_irregular_coat_pigmentation0.98780054
67MP0002697_abnormal_eye_size0.96798195
68MP0004742_abnormal_vestibular_system0.96681529
69MP0002249_abnormal_larynx_morphology0.96436997
70MP0004924_abnormal_behavior0.96325157
71MP0005386_behavior/neurological_phenoty0.96325157
72MP0000647_abnormal_sebaceous_gland0.95889486
73MP0002557_abnormal_social/conspecific_i0.93320820
74MP0002751_abnormal_autonomic_nervous0.93061187
75MP0002064_seizures0.91041338
76MP0002752_abnormal_somatic_nervous0.90139515
77MP0001905_abnormal_dopamine_level0.89553187
78MP0001963_abnormal_hearing_physiology0.86071693
79MP0004043_abnormal_pH_regulation0.85580737
80MP0003942_abnormal_urinary_system0.84610699
81MP0002152_abnormal_brain_morphology0.83065887
82MP0003119_abnormal_digestive_system0.82888825
83MP0003698_abnormal_male_reproductive0.81886764
84MP0006036_abnormal_mitochondrial_physio0.80390835
85MP0005195_abnormal_posterior_eye0.80036672
86MP0002177_abnormal_outer_ear0.79760387
87MP0003890_abnormal_embryonic-extraembry0.79064772
88MP0005220_abnormal_exocrine_pancreas0.77447227
89MP0002882_abnormal_neuron_morphology0.76257067
90MP0002069_abnormal_eating/drinking_beha0.75963542
91MP0001270_distended_abdomen0.74902088
92MP0003755_abnormal_palate_morphology0.74717521
93MP0001340_abnormal_eyelid_morphology0.73973152
94MP0004859_abnormal_synaptic_plasticity0.73117587
95MP0001188_hyperpigmentation0.72908611
96MP0000762_abnormal_tongue_morphology0.69478329
97MP0000579_abnormal_nail_morphology0.68732215
98MP0002095_abnormal_skin_pigmentation0.68569405
99MP0008995_early_reproductive_senescence0.68008360
100MP0003638_abnormal_response/metabolism_0.67871502

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.95753970
2Type II lissencephaly (HP:0007260)4.33053533
3Hypothermia (HP:0002045)4.05465415
4Abnormal number of erythroid precursors (HP:0012131)3.90192968
5Diastasis recti (HP:0001540)3.82907077
6Absent septum pellucidum (HP:0001331)3.72972214
7Abnormality of cells of the erythroid lineage (HP:0012130)3.71701208
8Medial flaring of the eyebrow (HP:0010747)3.59969310
9Nephronophthisis (HP:0000090)3.49342178
10Bilateral microphthalmos (HP:0007633)3.45608657
11Focal motor seizures (HP:0011153)3.39893159
12True hermaphroditism (HP:0010459)3.38914361
13Pancreatic fibrosis (HP:0100732)3.25598913
14Oligodactyly (hands) (HP:0001180)3.10131653
15Oligodactyly (HP:0012165)3.07963502
16Molar tooth sign on MRI (HP:0002419)3.05269626
17Abnormality of midbrain morphology (HP:0002418)3.05269626
18Abnormality of the septum pellucidum (HP:0007375)3.03045548
19Acute lymphatic leukemia (HP:0006721)2.99590229
20Optic nerve hypoplasia (HP:0000609)2.88690314
21Limb dystonia (HP:0002451)2.88298585
22Acute necrotizing encephalopathy (HP:0006965)2.87849191
23Increased hepatocellular lipid droplets (HP:0006565)2.79143053
24Anophthalmia (HP:0000528)2.78042964
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.77897177
26Pancreatic cysts (HP:0001737)2.74483167
27Esophageal atresia (HP:0002032)2.71224104
28Cerebellar dysplasia (HP:0007033)2.68690940
29Abnormality of the renal medulla (HP:0100957)2.67712722
30Chronic hepatic failure (HP:0100626)2.67171316
31Partial duplication of thumb phalanx (HP:0009944)2.66933978
32Growth hormone deficiency (HP:0000824)2.65173380
33Abnormality of the labia minora (HP:0012880)2.61391513
34Hypogonadotrophic hypogonadism (HP:0000044)2.61326856
35Gastrointestinal atresia (HP:0002589)2.60882435
36Renal Fanconi syndrome (HP:0001994)2.54132309
37Congenital primary aphakia (HP:0007707)2.52401469
38Gait imbalance (HP:0002141)2.50732960
39Limb hypertonia (HP:0002509)2.48114168
40Infantile muscular hypotonia (HP:0008947)2.45946968
41Fibular hypoplasia (HP:0003038)2.43143497
42Lipid accumulation in hepatocytes (HP:0006561)2.43097749
43Abnormal ciliary motility (HP:0012262)2.41587992
44Abnormal respiratory epithelium morphology (HP:0012253)2.40775183
45Abnormal respiratory motile cilium morphology (HP:0005938)2.40775183
46Abnormal rod and cone electroretinograms (HP:0008323)2.39195906
47Progressive macrocephaly (HP:0004481)2.33769564
48Hyperventilation (HP:0002883)2.32572406
49Abnormal drinking behavior (HP:0030082)2.32260795
50Polydipsia (HP:0001959)2.32260795
51Genital tract atresia (HP:0001827)2.31478064
52Mitochondrial inheritance (HP:0001427)2.26117731
53Macrocytic anemia (HP:0001972)2.25804127
54Vaginal atresia (HP:0000148)2.22996431
55Severe visual impairment (HP:0001141)2.19265529
56Abnormal mitochondria in muscle tissue (HP:0008316)2.18745847
57Acute encephalopathy (HP:0006846)2.18640076
58Split foot (HP:0001839)2.18493650
59Partial duplication of the phalanx of hand (HP:0009999)2.18221571
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.16984490
61Absent/shortened dynein arms (HP:0200106)2.16984490
62Nephrogenic diabetes insipidus (HP:0009806)2.14860718
63Bony spicule pigmentary retinopathy (HP:0007737)2.14321924
64Depressed nasal tip (HP:0000437)2.13553436
65Sclerocornea (HP:0000647)2.13483989
66Anencephaly (HP:0002323)2.10007386
67Postaxial hand polydactyly (HP:0001162)2.08396533
68Retinal atrophy (HP:0001105)2.04079857
69Maternal diabetes (HP:0009800)2.03633243
70Hemiplegia (HP:0002301)2.03341270
71Severe muscular hypotonia (HP:0006829)2.01436711
72Cystic liver disease (HP:0006706)1.98201967
73Decreased circulating renin level (HP:0003351)1.96929977
74Lissencephaly (HP:0001339)1.96814767
75Atonic seizures (HP:0010819)1.96163572
76Increased CSF lactate (HP:0002490)1.94730122
77Abnormal respiratory motile cilium physiology (HP:0012261)1.94629686
78Attenuation of retinal blood vessels (HP:0007843)1.93544510
79Tubular atrophy (HP:0000092)1.92773849
80Reticulocytopenia (HP:0001896)1.90284534
81Slender build (HP:0001533)1.89676922
82Poor coordination (HP:0002370)1.88281783
83Short tibia (HP:0005736)1.86836361
84Intestinal atresia (HP:0011100)1.86769396
85Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86570204
86Hemivertebrae (HP:0002937)1.82691332
87Decreased testicular size (HP:0008734)1.82626847
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82219396
89Optic nerve coloboma (HP:0000588)1.80415881
90Synostosis involving the elbow (HP:0003938)1.79433816
91Humeroradial synostosis (HP:0003041)1.79433816
92Congenital hepatic fibrosis (HP:0002612)1.78850166
93Supernumerary spleens (HP:0009799)1.78670397
94Stenosis of the external auditory canal (HP:0000402)1.78371269
95Aplasia/Hypoplasia of the fibula (HP:0006492)1.75951946
96Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.75738959
97Retinal dysplasia (HP:0007973)1.75027618
98Abnormality of renal resorption (HP:0011038)1.74588516
99Hemiparesis (HP:0001269)1.73312711
100Type 2 muscle fiber atrophy (HP:0003554)1.73191405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK8.14526547
2MAPK155.92407462
3TSSK63.66884229
4MKNK22.90824786
5WEE12.52869322
6TNIK2.52161849
7NTRK22.24023023
8VRK12.15392118
9ZAK2.03329686
10BMPR1B2.00589949
11ACVR1B1.95169315
12MKNK11.81024373
13VRK21.80504127
14MAP3K121.72378297
15TGFBR11.71775885
16CASK1.67069075
17PLK41.59754854
18BRSK21.56268887
19PRKCG1.51275430
20MAP2K41.51050589
21PRKD31.44045068
22EPHA41.42196499
23MUSK1.41957157
24MAPK131.38698286
25MAP3K41.34118911
26ERBB41.32466544
27PASK1.30420819
28PLK21.23200016
29CAMKK21.16541747
30PBK1.13203258
31WNK31.07845272
32PLK31.07254846
33CAMK1G1.06153002
34TIE11.03075874
35STK161.00684979
36CDK80.98714944
37TAOK10.98150200
38ERBB30.97465624
39EIF2AK30.89411390
40BUB10.85570829
41MARK10.84021528
42PRKCQ0.83600061
43MAP2K70.82583745
44ADRBK20.81500643
45GRK10.72664660
46DYRK30.72009909
47CAMK2B0.68889846
48PRKCE0.67284302
49MAPKAPK30.66575467
50TEC0.60234401
51TLK10.59584163
52TAOK30.58470678
53FGFR20.55130247
54EIF2AK20.54493261
55MAPKAPK50.53414827
56DYRK20.50064600
57YES10.47836478
58NTRK30.47137371
59TTK0.46038022
60WNK40.45768785
61PAK20.45711057
62SGK10.45318456
63CSNK1G20.43563152
64EIF2AK10.43060826
65STK240.42474181
66MAP3K60.42224820
67NEK90.42219633
68STK38L0.42016140
69PINK10.41700501
70IRAK10.40990834
71INSRR0.39996995
72CCNB10.37859449
73STK30.37586303
74PRKCZ0.33388108
75ADRBK10.32728552
76PTK2B0.32245084
77MAP3K50.31669730
78LRRK20.31149557
79NUAK10.31067009
80BRD40.30172898
81CDK30.30080101
82OXSR10.29265992
83NEK20.28987356
84CAMK10.28795827
85LATS20.28440669
86STK390.28400525
87CAMK2A0.28023747
88BRSK10.26450137
89CSNK1E0.25499968
90CAMK2D0.24311399
91CSNK1G10.22736549
92PRKACA0.22695774
93FGR0.22321286
94MAP2K60.21644760
95PLK10.20727877
96OBSCN0.20664479
97PHKG20.20569105
98PHKG10.20569105
99BCKDK0.19245695
100PRKG10.19131544

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.17727000
2Oxidative phosphorylation_Homo sapiens_hsa001903.67496382
3Protein export_Homo sapiens_hsa030603.35795974
4Parkinsons disease_Homo sapiens_hsa050123.32403819
5RNA polymerase_Homo sapiens_hsa030203.02435870
6Nicotine addiction_Homo sapiens_hsa050332.59148311
7Huntingtons disease_Homo sapiens_hsa050162.51400379
8Alzheimers disease_Homo sapiens_hsa050102.07032627
9Amphetamine addiction_Homo sapiens_hsa050311.98332990
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.89496522
11Cardiac muscle contraction_Homo sapiens_hsa042601.89222072
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.83604932
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67125048
14Nitrogen metabolism_Homo sapiens_hsa009101.66129034
15RNA degradation_Homo sapiens_hsa030181.65770365
16Cocaine addiction_Homo sapiens_hsa050301.59761770
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54287768
18Glutamatergic synapse_Homo sapiens_hsa047241.51563902
19Tryptophan metabolism_Homo sapiens_hsa003801.47224074
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47171562
21Propanoate metabolism_Homo sapiens_hsa006401.46816604
22One carbon pool by folate_Homo sapiens_hsa006701.35389635
23Dorso-ventral axis formation_Homo sapiens_hsa043201.33541820
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.29276805
25Taste transduction_Homo sapiens_hsa047421.27384261
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27015553
27Circadian entrainment_Homo sapiens_hsa047131.22839982
28Regulation of autophagy_Homo sapiens_hsa041401.19579636
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16686525
30Spliceosome_Homo sapiens_hsa030401.15024208
31Sulfur metabolism_Homo sapiens_hsa009201.12760376
32Butanoate metabolism_Homo sapiens_hsa006501.11798527
33Serotonergic synapse_Homo sapiens_hsa047261.09221501
34Basal cell carcinoma_Homo sapiens_hsa052171.07424584
35Phototransduction_Homo sapiens_hsa047441.06921876
36Hedgehog signaling pathway_Homo sapiens_hsa043400.99189645
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98759409
38GABAergic synapse_Homo sapiens_hsa047270.97641061
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96956514
40Purine metabolism_Homo sapiens_hsa002300.93950070
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93489527
42Proteasome_Homo sapiens_hsa030500.93157770
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88758683
44Steroid biosynthesis_Homo sapiens_hsa001000.86870838
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86177102
46Sulfur relay system_Homo sapiens_hsa041220.84866238
47Homologous recombination_Homo sapiens_hsa034400.84025638
48Peroxisome_Homo sapiens_hsa041460.83715519
49Olfactory transduction_Homo sapiens_hsa047400.81365361
50Axon guidance_Homo sapiens_hsa043600.80748933
51Renin secretion_Homo sapiens_hsa049240.80606189
52Morphine addiction_Homo sapiens_hsa050320.80123035
53Pyrimidine metabolism_Homo sapiens_hsa002400.79879832
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79522784
55RNA transport_Homo sapiens_hsa030130.77436511
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76148658
57Oxytocin signaling pathway_Homo sapiens_hsa049210.75438512
58Collecting duct acid secretion_Homo sapiens_hsa049660.74953005
59Calcium signaling pathway_Homo sapiens_hsa040200.73943338
60Basal transcription factors_Homo sapiens_hsa030220.73679741
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73594299
62Long-term potentiation_Homo sapiens_hsa047200.72796128
63Selenocompound metabolism_Homo sapiens_hsa004500.72364088
64Circadian rhythm_Homo sapiens_hsa047100.72096595
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67153956
66Long-term depression_Homo sapiens_hsa047300.64493525
67Base excision repair_Homo sapiens_hsa034100.64424223
68Dopaminergic synapse_Homo sapiens_hsa047280.63812829
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58850961
70Chemical carcinogenesis_Homo sapiens_hsa052040.57584158
71cAMP signaling pathway_Homo sapiens_hsa040240.57457887
72Wnt signaling pathway_Homo sapiens_hsa043100.56089014
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54822825
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54673985
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.53573986
76Oocyte meiosis_Homo sapiens_hsa041140.51374239
77Linoleic acid metabolism_Homo sapiens_hsa005910.50904830
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50808691
79Phenylalanine metabolism_Homo sapiens_hsa003600.50389134
80beta-Alanine metabolism_Homo sapiens_hsa004100.49283395
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48416574
82TGF-beta signaling pathway_Homo sapiens_hsa043500.48153858
83Metabolic pathways_Homo sapiens_hsa011000.47652588
84Retinol metabolism_Homo sapiens_hsa008300.46853358
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45370515
86Vitamin B6 metabolism_Homo sapiens_hsa007500.44674442
87Caffeine metabolism_Homo sapiens_hsa002320.44313587
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42897677
89Fanconi anemia pathway_Homo sapiens_hsa034600.42423101
90Gap junction_Homo sapiens_hsa045400.41101000
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40951923
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40673252
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39817434
94Hippo signaling pathway_Homo sapiens_hsa043900.38162701
95MAPK signaling pathway_Homo sapiens_hsa040100.37633776
96Fatty acid elongation_Homo sapiens_hsa000620.35092306
97Rheumatoid arthritis_Homo sapiens_hsa053230.34571609
98Ether lipid metabolism_Homo sapiens_hsa005650.34195486
99Fat digestion and absorption_Homo sapiens_hsa049750.32491530
100Histidine metabolism_Homo sapiens_hsa003400.32359838

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